COL19A1 Gene

Aliases
for COL19A1 gene

Previous GC identifers: GC06P070534 GC06P070572 GC06P067767

Summaries
for COL19A1 gene

Genomic Views
for COL19A1 gene

RefSeq DNA sequence:

NC_000006.11  NC_018917.1  NT_007299.13  

SwitchGear Promoter luciferase reporter plasmid: COL19A1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL19A1

COL19A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P070633:  view genomic region     (about GC identifiers)

Proteins
for COL19A1 gene

Explore the universe of human proteins at neXtProt for COL19A1: NX_Q14993

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: COL19A1 OriGene Custom Protein Services for COL19A1
	GenScript Custom Purified and Recombinant Proteins Services for COL19A1
	Novus Biologicals COL19A1 Protein Novus Biologicals COL19A1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse OriGene Antibodies OriGene Custom Antibody Services for COL19A1
	GenScript Custom Superior Antibodies Services for COL19A1
	Novus Biologicals COL19A1 Antibodies
	Search for Antibodies for COL19A1 at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for COL19A1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for COL19A1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for COL19A1 gene

ProtoNet protein and cluster: Q14993

Function
for COL19A1 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL19A1
		8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate COL19A1 (see all 79):
		hsa-miR-194* hsa-miR-106a hsa-miR-199a-3p hsa-miR-3138 hsa-miR-3074-3p hsa-miR-519a hsa-miR-502-3p hsa-miR-93
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL19A1 (see all 4) OriGene shRNA RFP: COL19A1 OriGene siRNA: COL19A1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL19A1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for COL19A1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COL19A1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COL19A1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COL19A1 (NM_001858)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL19A1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL19A1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COL19A1
		Search LifeMap BioReagents cell lines for COL19A1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL19A1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Col19a1)

Pathways & Interactions
for COL19A1 gene

	Super-pathway	contained gene-specific pathways
1	Integrin Pathway	Integrin Pathway 1.00 UPA-UPAR Pathway 0.51 FAK1 Signaling 0.67 Transendothelial Migration of Leukocytes 0.38 GnRH Signaling 0.56 Inhibition of Angiogenesis by TSP1 0.37
2	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
3	Collagen formation	Collagen formation 1.00 Extracellular matrix organization 0.54 Collagen biosynthesis and modifying enzymes 0.74 Secretion of collagens 0.49
4	Degradation of the extracellular matrix	Degradation of the extracellular matrix 1.00 Degradation of collagen 0.79
5	Blood Coagulation Cascade	Blood Coagulation Cascade 1.00 Intrinsic Prothrombin Activation Pathway 0.96

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL19A1

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

5/7        Reactome Pathways for COL19A1

	Collagen type XIX degradation
	Extracellular matrix organization
	Secretion of collagens
	Collagen biosynthesis and modifying enzymes
	Degradation of the extracellular matrix

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for COL19A1 gene

Transcripts
for COL19A1 gene

Expression
for COL19A1 gene

COL19A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

5 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeInner Nuclear LayerType1 Off Cone Bipolar Cells			Bipolar, Retina
	BoneCaudal Skull Membranous Bones			Bone
	BoneEndochondral Facial Bones			Bone
	BoneRostral Skull Membranous Bones			Bone
	BoneThoracic Rib			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Primitive gut tube-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COL19A1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COL19A1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL19A1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL19A1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL19A1

Orthologs
for COL19A1 gene

Paralogs
for COL19A1 gene

Paralogs for COL19A1 gene

COL4A6²  COL11A2²  COL4A5²  COL24A1²  COL4A4²  COL5A3²  COL1A1²  COL16A1²  

COL4A2²  COL5A2²  COL5A1²  COL4A3²  COL22A1²  COL7A1²  COL1A2²  COL27A1²  

COL3A1²  COL2A1²  COL4A1²  COL11A1²  

1 SIMAP similar gene for COL19A1 using alignment to 2 protein entries:     COJA1_HUMAN (see all proteins):

COL10A1

COL19A1 for paralogs           About GeneDecksing

Genomic Variants
for COL19A1 gene

10/5603 NCBI SNPs in COL19A1 are shown (see all 5603)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1477262231,2		--	70574767(+)	CAATAC/TTAGAA	1	--	us2k1		0	--	--	--	--
rs1907456981,2		--	70574831(+)	TCAAAG/TATCTT	1	--	us2k1		0	--	--	--	--
rs1492167551,2		--	70574834(+)	AATATC/GTTAAC	1	--	us2k1		0	--	--	--	--
rs1434132781,2		--	70574853(+)	AATTAC/TTAAAA	1	--	us2k1		0	--	--	--	--
rs1483781791,2		--	70574871(+)	GAAAAC/TAATTC	1	--	us2k1		0	--	--	--	--
rs24874311,2	C,F,A,	--	70574925(+)	CAAAAC/TTGTGG	1	--	us2k1		11		NA WA CSA EA	373
rs1823648451,2		--	70575060(+)	GCAAGG/TTATAT	1	--	us2k1		0	--	--	--	--
rs1861806741,2		--	70575193(+)	AGCGTA/GACTCA	1	--	us2k1		0	--	--	--	--
rs1140557331,2	F,	--	70575195(+)	CGTGAC/TTCATG	1	--	us2k1		1		WA	118
rs1910323511,2		--	70575277(+)	ATGTAC/TCAAGT	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for COL19A1 (70576448 - 70826448 bp, first 250kb of COL19A1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for COL19A1
     2 CNVs: 30238 30237
     2 Indels: 60601 59359

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COL19A1

DNA2.0 Custom Variant and Variant Library Synthesis for COL19A1

Disorders / Diseases
for COL19A1 gene

Publications
for COL19A1 gene

PubMed articles for COL19A1 gene, integrated from 9 sources (see all 18): (articles sorted by number of sources associating them with COL19A1)

Utopia: connect your pdf to the dynamic world of online information

1. Human cDNA clones transcribed from an unusually high-molecular-weight RNA encode a new collagen chain. (PubMed id 7916703)^{1, 2, 3} Myers J.C....Dion A.S. (1993)
2. Structure of the human type XIX collagen (COL19A1) gene, which suggests it has arisen from an ancestor gene of the FACIT family. (PubMed id 9344653)^{1, 2, 9} Khaleduzzaman M....Yoshioka H. (1997)
3. Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13. (PubMed id 9143499)^{1, 3, 9} Gerecke D.R.... Burgeson R.E. (1997)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Type XIX collagen purified from human umbilical cord is characterized by multiple sharp kinks delineating collagenous subdomains and by intermolecular aggregates via globular, disulfide-linked, and heparin- binding amino termini. (PubMed id 12788917)^{1, 2} Myers J.C.... Weisel J.W. (2003)
6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
7. The mRNA for alpha 1(XIX) collagen chain, a new member of FACITs, contains a long unusual 3' untranslated region and displays many unique splicing variants. (PubMed id 7775380)^{1, 2} Inoguchi K.... Ninomiya Y. (1995)
8. The triple-helical region of human type XIX collagen consists of multiple collagenous subdomains and exhibits limited sequence homology to alpha 1(XVI). (PubMed id 8034603)^{1, 2} Myers J.C....Dion A.S. (1994)
9. Synteny between the loci for a novel FACIT-like collagen locus (D6S228E) and alpha 1 (IX) collagen (COL9A1) on 6q12-q14 in humans. (PubMed id 1639419)^{1, 2} Yoshioka H.... Gordon M.K. (1992)
10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

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Products
for COL19A1 gene