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COL19A1 Gene

protein-coding   GIFtS: 53
GCID: GC06P070633

Collagen, Type XIX, Alpha 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Collagen, Type XIX, Alpha 11 2     A1 Chain Of Type XIX Collagen2
Collagen Alpha-1(Y) Chain2 3     Collagen Alpha 1 (Y) Chain2
COL9A1L2 5     Collagen Alpha-1(XIX) Chain2
D6S228E2 5     Collagen XIX, Alpha-1 Polypeptide2

External Ids:    HGNC: 21961   Entrez Gene: 13102   Ensembl: ENSG000000822937   OMIM: 1201655   UniProtKB: Q149933   

Export aliases for COL19A1 gene to outside databases

Previous GC identifers: GC06P070534 GC06P070572 GC06P067767


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COL19A1 Gene:
This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated
collagens with interrupted helices). Although the function of this collagen is not known, other members of this
collagen family are found in association with fibril-forming collagens such as type I and II, and serve to
maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large
3' UTR which has not been completely sequenced. (provided by RefSeq, Jul 2008)

GeneCards Summary for COL19A1 Gene:
COL19A1 (collagen, type XIX, alpha 1) is a protein-coding gene. GO annotations related to this gene include extracellular matrix structural constituent and protein binding, bridging. An important paralog of this gene is COL25A1.

UniProtKB/Swiss-Prot: COJA1_HUMAN, Q14993
Function: May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal
myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the
sphinteric smooth muscle

Gene Wiki entry for COL19A1 (Collagen, type XIX, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the COL19A1 gene promoter:
         Spz1   Pbx1a   Brachyury   HTF   C/EBPalpha   FOXL1   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOL19A1 promoter sequence
   Search Chromatin IP Primers for COL19A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COL19A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q12-q13   Ensembl cytogenetic band:  6q13   HGNC cytogenetic band: 6q12-q13

COL19A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL19A1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P070633:  view genomic region     (about GC identifiers)

Start:
70,576,448 bp from pter      End:
70,922,157 bp from pter
Size:
345,710 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COJA1_HUMAN, Q14993 (See protein sequence)
Recommended Name: Collagen alpha-1(XIX) chain precursor  
Size: 1142 amino acids; 115221 Da
Subunit: Oligomer; disulfide-linked
Sequence caution: Sequence=CAC12699.3; Type=Erroneous gene model prediction; Sequence=CAI42319.2; Type=Erroneous
gene model prediction; Sequence=CAI42496.2; Type=Erroneous gene model prediction;
Secondary accessions: Q00559 Q05850 Q12885 Q13676 Q14DH1 Q5JUF0 Q5T424 Q9H572 Q9NPZ2 Q9NQP2

Explore the universe of human proteins at neXtProt for COL19A1: NX_Q14993

Explore proteomics data for COL19A1 at MOPED

Post-translational modifications: 

  • Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the
    chains1
  • Glycosylation2 at Ser272, Ser273
  • Modification sites at PhosphoSitePlus

  • See COL19A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001849.2  
    ENSEMBL proteins: 
     ENSP00000316030   ENSP00000377013   ENSP00000416556  
    Reactome Protein details: Q14993

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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COLLAGEN: Collagens

    4 InterPro protein domains:
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR008160 Collagen
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q14993

    ProtoNet protein and cluster: Q14993

    3 Blocks protein domains:
    IPB003129 Thrombospondin
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: COJA1_HUMAN, Q14993
    Domain: The numerous interruptions in the triple helix may make this molecule either elastic or flexible
    Similarity: Belongs to the fibril-associated collagens with interrupted helices (FACIT) family
    Similarity: Contains 11 collagen-like domains
    Similarity: Contains 1 laminin G-like domain


    Find genes that share domains with COL19A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COJA1_HUMAN, Q14993
    Function: May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal
    myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the
    sphinteric smooth muscle

         Genatlas biochemistry entry for COL19A1:
    collagen,type XIX,alpha 1,fibril associated collagen with interrupted triple helices (FACIT),expressed in
    cartilage

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent NAS1639419
    GO:0030674protein binding, bridging NAS1639419
         
    Find genes that share ontologies with COL19A1           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Col19a1):
     behavior/neurological  digestive/alimentary  growth/size/body  integument  mortality/aging 
     muscle 

    Find genes that share phenotypes with COL19A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for COL19A1: Col19a1tm2Rmz Col19a1tm1Rmz

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COL19A1
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    hsa-miR-194* hsa-miR-106a hsa-miR-199a-3p hsa-miR-3138 hsa-miR-3074-3p hsa-miR-519a hsa-miR-502-3p hsa-miR-93
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COJA1_HUMAN, Q14993: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4
    mitochondrion3
    cytosol1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix NAS1639419
    GO:0005581collagen NAS7775380
    GO:0005788endoplasmic reticulum lumen TAS--

    Find genes that share ontologies with COL19A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COL19A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Intrinsic Prothrombin Activation Pathway0.39
    Collagen formation0.75
    Blood Coagulation Cascade0.38
    2Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    5Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56


    Find genes that share SuperPaths with COL19A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for COL19A1 (see all 15)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    2 Reactome Pathways for COL19A1
        Collagen biosynthesis and modifying enzymes
    Collagen degradation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COL19A1
    Interactions:

        Search GeneGlobe Interaction Network for COL19A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COL19A1 (ENSP000003160304) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL11A1ENSP000003511634STRING: ENSP00000351163
    COL12A1ENSP000003251464STRING: ENSP00000325146
    COL13A1ENSP000003486954STRING: ENSP00000348695
    COL14A1ENSP000002978484STRING: ENSP00000297848
    COL15A1ENSP000003641404STRING: ENSP00000364140
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS9143499
    GO:0007155cell adhesion NAS7775380
    GO:0007519skeletal muscle tissue development IEA--
    GO:0016337cell-cell adhesion NAS1639419
    GO:0022617extracellular matrix disassembly TAS--

    Find genes that share ontologies with COL19A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COL19A1 (COJA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COL19A1 gene: 
    NM_001858.4  

    Unigene Cluster for COL19A1:

    Collagen, type XIX, alpha 1
    Hs.444842  [show with all ESTs]
    Unigene Representative Sequence: NM_001858
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322773(uc003pfc.1 uc010kam.2) ENST00000478620 ENST00000476656
    ENST00000483745 ENST00000393344 ENST00000455415
    miRNA
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    hsa-miR-194* hsa-miR-106a hsa-miR-199a-3p hsa-miR-3138 hsa-miR-3074-3p hsa-miR-519a hsa-miR-502-3p hsa-miR-93
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    Additional mRNA sequence: 

    AK309023.1 AK310621.1 BC070177.1 BC113362.1 BC113364.1 D38163.1 M63597.1 U09279.1 

    2 DOTS entries:

    DT.209387  DT.95286205 

    16 AceView cDNA sequences:

    CA396452 BC070177 NM_001858 AW614561 M63597 D38163 BF434455 BG399866 
    AL705169 U09279 L12347 AA904409 AW139403 CF144008 CD694117 BG217174 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COL19A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    COL19A1 Expression
    About this image


    COL19A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Endochondral Facial Bones
     
     Neurons
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
    COL19A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COL19A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444842

    UniProtKB/Swiss-Prot: COJA1_HUMAN, Q14993
    Tissue specificity: Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in
    umbilical cord

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL19A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for COL19A1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Col19a11 , 5 collagen, type XIX, alpha 11, 5 85.89(n)1
    83.54(a)1
      1 (9.99 cM)5
    128231  NM_007733.21  NP_031759.21 
     242618905 
    chicken
    (Gallus gallus)
    Aves COL19A11 collagen, type XIX, alpha 1 71.99(n)
    68.22(a)
      421873  XM_004940450.1  XP_004940507.1 
    lizard
    (Anolis carolinensis)
    Reptilia COL19A16
    collagen, type XIX, alpha 1
    63(a)
    1 ↔ 1
    1(167240397-167410048)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia col19a11 collagen, type XIX, alpha 1 63.82(n)
    60.73(a)
      100488633  XM_002939407.2  XP_002939453.2 
    zebrafish
    (Danio rerio)
    Actinopterygii col19a16
    COL19A1 (3 of 3)6
    (see all 3)
    collagen, type XIX, alpha 1
    (see all 3)
    57(a)
    40(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    13(39550948-39675972) ENSDARG00000076163
    13(39211941-39482740) ENSDARG00000096073


    ENSEMBL Gene Tree for COL19A1 (if available)
    TreeFam Gene Tree for COL19A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COL19A1 gene
    COL25A12  COL9A12  COL22A12  COL13A12  COL9A32  COL9A22  COL16A12  COL21A12  
    COL23A12  

    Find genes that share paralogs with COL19A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COL19A1 (see all 6608)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357464
    A breast cancer sample4--see VAR_0357462 G D mis40--------
    VAR_0357474
    A breast cancer sample4--see VAR_0357472 K N mis40--------
    rs1477262231,2
    --70574767(+) CAATAC/TTAGAA 1 -- us2k10--------
    rs1907456981,2
    --70574831(+) TCAAAG/TATCTT 1 -- us2k10--------
    rs1492167551,2
    --70574834(+) AATATC/GTTAAC 1 -- us2k10--------
    rs1434132781,2
    C--70574853(+) AATTAC/TTAAAA 1 -- us2k10--------
    rs1483781791,2
    --70574871(+) GAAAAC/TAATTC 1 -- us2k10--------
    rs24874311,2
    C,F,A--70574925(+) CAAAAC/TTGTGG 1 -- us2k111Minor allele frequency- T:0.25NA WA CSA EA 373
    rs1823648451,2
    --70575060(+) GCAAGG/TTATAT 1 -- us2k10--------
    rs1861806741,2
    --70575193(+) AGCGTA/GACTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COL19A1 (70576448 - 70826448 bp, first 250kb of COL19A1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for COL19A1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658033CNV Deletion23128226
    esv2663730CNV Deletion23128226
    esv2732254CNV Deletion23290073
    nsv507337CNV Insertion20534489
    nsv511895CNV Loss21212237
    nsv886141CNV Loss21882294
    nsv819361CNV Loss19587683
    nsv830682CNV Loss17160897
    nsv463151CNV Loss19166990
    nsv525985CNV Loss19592680

    Human Gene Mutation Database (HGMD): COL19A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COL19A1
    DNA2.0 Custom Variant and Variant Library Synthesis for COL19A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 120165    OMIM disorders: --


    Find genes that share disorders with COL19A1           About GenesLikeMe

    Genetic Association Database (GAD): COL19A1
    Human Genome Epidemiology (HuGE) Navigator: COL19A1 (1 document)

    Export disorders for COL19A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COL19A1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with COL19A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cDNA clones transcribed from an unusually high-molecular-weight RNA encode a new collagen chain. (PubMed id 7916703)1, 2, 3 Myers J.C....Dion A.S. (Gene 1993)
    2. Structure of the human type XIX collagen (COL19A1) gene, which suggests it has arisen from an ancestor gene of the FACIT family. (PubMed id 9344653)1, 2, 9 Khaleduzzaman M....Yoshioka H. (Genomics 1997)
    3. Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13. (PubMed id 9143499)1, 3, 9 Gerecke D.R.... Burgeson R.E. (Genomics 1997)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Type XIX collagen purified from human umbilical cord is characterized by multiple sharp kinks delineating collagenous subdomains and by intermolecular aggregates via globular, disulfide-linked, and heparin- binding amino termini. (PubMed id 12788917)1, 2 Myers J.C.... Weisel J.W. (J. Biol. Chem. 2003)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. The mRNA for alpha 1(XIX) collagen chain, a new member of FACITs, contains a long unusual 3' untranslated region and displays many unique splicing variants. (PubMed id 7775380)1, 2 Inoguchi K.... Ninomiya Y. (J. Biochem. 1995)
    9. The triple-helical region of human type XIX collagen consists of multiple collagenous subdomains and exhibits limited sequence homology to alpha 1(XVI). (PubMed id 8034603)1, 2 Myers J.C....Dion A.S. (J. Biol. Chem. 1994)
    10. Synteny between the loci for a novel FACIT-like collagen locus (D6S228E) and alpha 1 (IX) collagen (COL9A1) on 6q12-q14 in humans. (PubMed id 1639419)1, 2 Yoshioka H.... Gordon M.K. (Genomics 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1310 HGNC: 2196 AceView: COL19A1 Ensembl:ENSG00000082293 euGenes: HUgn1310
    ECgene: COL19A1 H-InvDB: COL19A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COL19A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COL19A1 gene:
    Search GeneIP for patents involving COL19A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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