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COL18A1 Gene

protein-coding   GIFtS: 69
GCID: GC21P046825

Collagen, Type XVIII, Alpha 1

(Previous names: Knobloch syndrome, type 1)
(Previous symbol: KNO)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Collagen, Type XVIII, Alpha 11 2     Human Type XVIII Collagen11
KNO1 2     KS2
endostatin1 2     Antiangiogenic Agent2
KNO12 5     Collagen Alpha-1(XVIII) Chain2
Knobloch Syndrome, Type 11     Multi-Functional Protein MFP2

External Ids:    HGNC: 21951   Entrez Gene: 807812   Ensembl: ENSG000001828717   OMIM: 1203285   UniProtKB: P390603   

Export aliases for COL18A1 gene to outside databases

Previous GC identifers: GC21P043334 GC21P045681 GC21P045649 GC21P032201


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COL18A1 Gene:
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular
matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous
domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent
antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this
syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure
and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for COL18A1 Gene:
COL18A1 (collagen, type XVIII, alpha 1) is a protein-coding gene. Diseases associated with COL18A1 include encephalocele, and knobloch syndrome type i. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is COL15A1.

UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060
Function: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of
the neural tube
Function: Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis
by binding to the heparan sulfate proteoglycans involved in growth factor signaling

Gene Wiki entry for COL18A1 (Collagen, type XVIII, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the COL18A1 gene promoter:
         p53   STAT3   NF-kappaB   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOL18A1 promoter sequence

   Search Chromatin IP Primers for COL18A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COL18A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
COL18A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL18A1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P046825:   GeneLoc Nature:405,311-319
Start:
46,825,052 bp from pter       32,384,934 bp from centromere
End:
46,933,634 bp from pter 32,443,158 bp from centromere
Size:
108,583 bases 58,225 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AF018081
genomic clones: P310E12 BAC-53I10


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060 (See protein sequence)
Recommended Name: Collagen alpha-1(XVIII) chain precursor  
Size: 1754 amino acids; 178188 Da
3 PDB 3D structures from and Proteopedia for COL18A1:
1BNL (3D)        3HON (3D)        3HSH (3D)    
Secondary accessions: A8MVI4 Q58EX6 Q6RZ39 Q6RZ40 Q6RZ41 Q8N4S4 Q8WXI5 Q96T70 Q9UK38 Q9Y6Q7
Q9Y6Q8
Alternative promoter usage, Alternative splicing: 3 isoforms:  P39060-3   P39060-1   P39060-2   (Produced by alternative promoter usage)

Explore the universe of human proteins at neXtProt for COL18A1: NX_P39060

Explore proteomics data for COL18A1 at MOPED

Post-translational modifications: 

  • Prolines at the third position of the tripeptide repeating unit (G-X-Y) of the triple-helical regions are
    hydroxylated1
  • Glycosylation2 at Asn68, Asn129, Asn164, Asn691, Thr1292, Ser1304, Thr1332
  • Modification sites at PhosphoSitePlus

  • See COL18A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_085059.2  NP_569712.2  

    ENSEMBL proteins: 
     ENSP00000383191   ENSP00000347665   ENSP00000339118   ENSP00000415692   ENSP00000352798  
    Reactome Protein details: P39060

    COL18A1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant COL18A1 Protein
    R&D Systems Recombinant & Natural Proteins for COL18A1 (Endostatin)
    Enzo Life Sciences proteins for COL18A1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for COL18A1
    GenScript Purified and Recombinant Proteins for COL18A1
    Novus Biologicals COL18A1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for COL18A1
    Browse Proteins at Cloud-Clone Corp.

    COL18A1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of COL18A1
    R&D Systems Antibodies for COL18A1 (Endostatin)
    OriGene Antibodies for COL18A1
    OriGene Custom Antibody Services for COL18A1
    Novus Biologicals COL18A1 Antibodies
    Abcam antibodies for COL18A1 (P39059, P39060)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for COL18A1
    LSBio Antibodies in human, mouse, rat for COL18A1

    COL18A1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COL18A1
    R&D Systems ELISAs for COL18A1 (Endostatin)         (see all)
    GenScript Custom Assay Services for COL18A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COLLAGEN: Collagens

    Selected InterPro protein domains (see all 9):
     IPR026917 COL18A1
     IPR001791 Laminin_G
     IPR020067 Frizzled_dom
     IPR016187 C-type_lectin_fold
     IPR010515 Collagenase_NC10/endostatin

    Graphical View of Domain Structure for InterPro Entry P39060

    ProtoNet protein and cluster: P39060

    5 Blocks protein domains:
    IPB001791 Laminin G
    IPB003129 Thrombospondin
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat
    IPB010515 Collagenase NC10 and endostatin


    UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060
    Similarity: Belongs to the multiplexin collagen family
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 1 laminin G-like domain


    COL18A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COIA1_HUMAN, P39060
    Function: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of
    the neural tube
    Function: Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis
    by binding to the heparan sulfate proteoglycans involved in growth factor signaling

         Genatlas biochemistry entry for COL18A1:
    collagen,type XVIII,alpha 1,multiplexin family with interrupted helical domain

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI17615292
    GO:0042802identical protein binding IPI16269408
    GO:0046872metal ion binding IEA--
         
    COL18A1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Col18a1):
     cardiovascular system  craniofacial  homeostasis/metabolism  nervous system  other 
     renal/urinary system  skeleton  tumorigenesis  vision/eye 

    COL18A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for COL18A1: Col18a1tm1(KOMP)Vlcg Col18a1tm1Hms

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COL18A1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COL18A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COL18A1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COL18A1

    miRNA
    Products:
        
    miRTarBase miRNAs that target COL18A1:
    hsa-mir-92a-3p (MIRT049203), hsa-mir-877-3p (MIRT037044)

    Block miRNA regulation of human, mouse, rat COL18A1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate COL18A1:
    hsa-miR-9 hsa-miR-526b hsa-miR-516a-3p hsa-miR-516b* hsa-miR-578 hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidCOL18A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COL18A1
    Predesigned siRNA for gene silencing in human, mouse, rat COL18A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COL18A1

    Clone
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    OriGene clones in human, mouse for COL18A1 (see all 12)
    OriGene ORF clones in mouse, rat for COL18A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): COL18A1 (NM_030582)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL18A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL18A1

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for COL18A1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL18A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COIA1_HUMAN, P39060: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    extracellular4
    plasma membrane3
    cytoskeleton1
    cytosol1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA--
    GO:0005788endoplasmic reticulum lumen TAS--

    COL18A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COL18A1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Intrinsic Prothrombin Activation Pathway0.39
    Collagen formation0.75
    Blood Coagulation Cascade0.38
    Assembly of collagen fibrils and other multimeric structures0.62
    2Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    5Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for COL18A1 (see all 15)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    2 BioSystems Pathways for COL18A1
        FOXA1 transcription factor network
    Direct p53 effectors

    Selected Reactome Pathways for COL18A1 (see all 6)
        Laminin interactions
    Integrin cell surface interactions
    Collagen biosynthesis and modifying enzymes
    Assembly of collagen fibrils and other multimeric structures
    Collagen degradation


    1 Kegg Pathway  (Kegg details for COL18A1):
        Protein digestion and absorption


    COL18A1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including COL18A1: 
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for COL18A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COL18A1 (P390601, 3 ENSP000003527984) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TECPR1Q7Z6L13, ENSP000004049234I2D: score=3 STRING: ENSP00000404923
    KDRP359683, ENSP000002639234I2D: score=1 STRING: ENSP00000263923
    TGM2P219801, ENSP000003553304EBI-2566375,EBI-727668 STRING: ENSP00000355330
    NCLP193381, ENSP000003181954EBI-2566375,EBI-346967 STRING: ENSP00000318195
    APPP050671EBI-2566375,EBI-821758
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001886endothelial cell morphogenesis IEA--
    GO:0007155cell adhesion IEA--
    GO:0007601visual perception TAS10942434
    GO:0008284positive regulation of cell proliferation IEA--

    COL18A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COL18A1 (COIA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COL18A1 gene (3 alternative transcripts): 
    NM_030582.3  NM_130445.2  NM_130444.2  

    Unigene Cluster for COL18A1:

    Collagen, type XVIII, alpha 1
    Hs.517356  [show with all ESTs]
    Unigene Representative Sequence: AF018081
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400337(uc002zhg.3) ENST00000355480(uc002zhi.3) ENST00000342220(uc002zhj.3 uc002zhk.3)
    ENST00000459895 ENST00000423214 ENST00000473212 ENST00000359759
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate COL18A1:
    hsa-miR-9 hsa-miR-526b hsa-miR-516a-3p hsa-miR-516b* hsa-miR-578 hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidCOL18A1 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): COL18A1 (NM_030582)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL18A1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for COL18A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COL18A1
      QuantiTect SYBR Green Assays in human, mouse, rat COL18A1
      QuantiFast Probe-based Assays in human, mouse, rat COL18A1

    Additional mRNA sequence: 

    AF018081.1 AF018082.1 AF184060.1 AF333246.1 AF333247.1 AF416592.1 AK098216.1 AK130835.1 
    AK311062.1 BC033715.1 BC063833.1 

    19 DOTS entries:

    DT.447571  DT.92001135  DT.91912586  DT.95302146  DT.121139495  DT.101985460  DT.100039632  DT.99986442 
    DT.95220877  DT.92436231  DT.100034049  DT.100039626  DT.40116647  DT.100039627  DT.95090195  DT.95349603 
    DT.100798481  DT.91744920  DT.99955859 

    Selected AceView cDNA sequences (see all 195):

    BG106854 AA350510 AA350511 AA470378 BU680493 AI076853 AK127669 AA350512 
    R86040 AA913825 AI814596 T28473 AA069352 AI738703 BU502539 BE881571 
    AI858077 AI970756 AA743360 AI763165 AI660746 AA731506 BQ003811 AI074505 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COL18A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATCCTCAA
    COL18A1 Expression
    About this image


    COL18A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Thymus (Hematopoietic System)
             Thymus
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    COL18A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COL18A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517356

    UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060
    Tissue specificity: Present in multiple organs with highest levels in liver, lung and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including COL18A1: 
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Angiogenesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for COL18A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COL18A1
    QuantiTect SYBR Green Assays in human, mouse, rat COL18A1
    QuantiFast Probe-based Assays in human, mouse, rat COL18A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL18A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for COL18A1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Col18a11 , 5 collagen, type XVIII, alpha 11, 5 75.59(n)1
    75.49(a)1
      10 (39.72 cM)5
    128221  NM_001109991.11  NP_001103461.11 
     770521785 
    chicken
    (Gallus gallus)
    Aves COL18A11 collagen, type XVIII, alpha 1 67.21(n)
    68.86(a)
      373978  NM_204164.1  NP_989495.1 
    lizard
    (Anolis carolinensis)
    Reptilia COL18A16
    collagen, type XVIII, alpha 1
    56(a)
    1 ↔ 1
    1(90395003-90458517)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB047066.12   -- 74.53(n)    AB047066.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AJ494837.12   -- 75.34(n)   360140  AJ494837.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mp6
    multiplexin
    29(a)
    1 → many
    3L(6991943-7046528)
    worm
    (Caenorhabditis elegans)
    Secernentea cle-13 cle-1 isoform A 33(a)   I(8714046-8732339)   --


    ENSEMBL Gene Tree for COL18A1 (if available)
    TreeFam Gene Tree for COL18A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for COL18A1 gene
    COL15A12  
    1 SIMAP similar gene for COL18A1 using alignment to 6 protein entries:     COIA1_HUMAN (see all proteins):
    COLQ

    COL18A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    COIA1_HUMAN, P39060: There is an association between a polymorphism in position 1675 and prostate cancer. Heterozygous
    Asn-1675 individuals have a 2.5 times increased chance of developing prostate cancer as compared with homozygous
    Asp-1675 individuals


    Selected SNPs for COL18A1 (see all 3734)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124833771,2,,4
    C,F,Hpathogenic146931109(+) CCTTTG/AACGGC 4 /N /D mis1 ese331Minor allele frequency- A:0.04NA NS EA MN EU 3505
    rs1911348801,2
    --46823185(+) CCCTGC/TCCCAG 1 -- us2k10--------
    rs1467271841,2
    --46823307(+) ATGGGG/TTGGGT 1 -- us2k10--------
    rs1403673981,2
    C--46823339(+) GGCAGA/GTGAGA 1 -- us2k10--------
    rs124825791,2
    H--46823369(+) CTGCAC/GTGCAG 1 -- us2k14Minor allele frequency- G:0.00NS EA 416
    rs786019091,2
    C,F--46823375(+) TGCAGG/CGTTAA 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs758842651,2
    C,F--46823382(+) TTAATG/TGACAG 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1833174191,2
    --46823512(+) ACAGAA/CACACA 1 -- us2k10--------
    rs1396933531,2
    C--46823544(+) GAGAG-/ACAT  
      GCACAC
    ACATG
    1 -- us2k10--------
    rs1868512501,2
    --46823702(+) TGTGCA/GATGAC 1 -- us2k10--------
    rs1913129001,2
    --46823859(+) GACCAA/GGTGGC 1 -- us2k10--------
    rs1848917371,2
    --46823922(+) GGCAGG/TGATGA 1 -- us2k10--------
    rs745705491,2
    F--46823944(+) GAGAAT/CCCCAA 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1381072051,2
    --46824060(+) GGAGGG/TCCGGG 1 -- us2k10--------
    rs3734986041,2
    C--46824194(+) TGGCCC/GGGAAG 1 -- us2k10--------
    rs803273341,2
    C,F--46824261(+) AGTGCC/TATGAG 1 -- us2k12Minor allele frequency- T:0.17NA EA 240
    rs777051561,2
    C--46824278(+) GCACAC/AGAGGA 1 -- us2k12Minor allele frequency- A:0.05CSA WA 120
    rs1409935101,2
    C--46824294(+) AGGCT-/GGGGGG 1 -- us2k10--------
    rs99818311,2
    C--46825028(+) gcccgC/Gcccct 1 -- us2k10--------
    rs1132722971,2
    C--46825214(+) GGGTCC/GCGGGG 1 -- int10--------
    rs604990341,2
    C--46825223(+) GGGTCC/GCGGGG 1 -- int10--------
    rs1853571031,2
    --46825235(+) TCGGCC/TGGGTC 1 -- int10--------
    rs1888526881,2
    --46825267(+) TGCGGG/TGTCTG 1 -- int10--------
    rs1819979001,2
    --46825665(+) GGCGGA/GGTCGT 1 -- int10--------
    rs345139681,2
    C,F--46825678(+) GTGCCG/CGGAGG 1 -- int11Minor allele frequency- C:0.50NA 2
    rs349756871,2
    C--46825723(+) GGCCTG/CTGTCG 1 -- int14Minor allele frequency- C:0.13NA EA 244
    rs622162801,2
    C--46825790(+) CGGCGG/AAGCGC 1 -- int15Minor allele frequency- A:0.29NA WA EA 362
    rs1389905651,2
    --46825796(+) AGCGCA/GGGGCG 1 -- int10--------
    rs1431113371,2
    C--46825975(+) AGCCGC/GTGCCC 1 -- int10--------
    rs1474953941,2
    --46826042(+) TTCCTA/GCCTCC 1 -- int10--------
    rs1143759411,2
    F--46826241(+) CTCCAC/GACCTG 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1168606341,2
    C,F--46826460(+) TCTAGG/TGGGTG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs560724311,2
    C--46826513(+) CCCACA/CGCGGC 1 -- int15Minor allele frequency- C:0.40NA WA EA 362
    rs802468271,2
    F--46826516(+) ACAGCA/GGCCCA 1 -- int10--------
    rs1419643611,2
    --46826582(+) AGCGCC/TCACAG 1 -- int10--------
    rs562062351,2
    C--46826677(+) CTTATG/AAAACG 1 -- int16Minor allele frequency- A:0.36NA WA EA 364
    rs1845842121,2
    --46826753(+) TAACGC/TGAGCT 1 -- int10--------
    rs72793401,2
    C,F,H--46832001(+) TGGCTC/TGTGCC 1 -- int18Minor allele frequency- T:0.08NS EA NA WA 494
    rs1890799401,2
    --46832036(+) TTCCCC/TGTAGC 1 -- int10--------
    rs2012833501,2
    --46832149(+) GTATA-/TTTC  
            
    TTTTT
    1 -- int10--------
    rs2010731051,2
    C--46832150(+) TATAT-/TTCTTTTT 1 -- int10--------
    rs2011239901,2
    C--46832151(+) ATATT-/TCTTTTT 1 -- int10--------
    rs30824761,2
    C,H--46832152(+) TATTTC/TTTTTT 1 -- int1 trp31Minor allele frequency- T:0.50WA 2
    rs1384193671,2
    C--46832152(+) TAttt-/CT/TT 
            
    ttttt
    1 -- int10--------
    rs1443460231,2
    --46832212(+) AGTGGC/TGTGAT 1 -- int10--------
    rs713340631,2
    C,F--46832345(+) AGAGAC/TGGGGT 1 -- int12Minor allele frequency- T:0.50NA 4
    rs99786181,2
    C--46832540(+) CAGCAA/GAGCTC 1 -- int10--------
    rs1415779931,2
    --46832555(+) GCCTGC/TGGCCC 1 -- int10--------
    rs1814626331,2
    --46832569(+) CACACA/GGACAA 1 -- int10--------
    rs1860631871,2
    --46832782(+) TGGCCA/GTCATC 1 -- int10--------
    rs1464079371,2
    --46832842(+) GAGAGC/TTCAGG 1 -- int10--------
    rs1397543741,2
    --46832915(+) AATCTC/GTGCCT 1 -- int10--------
    rs1921259271,2
    --46832940(+) GTCATA/GGGGCC 1 -- int10--------
    rs1137613421,2
    C,F--46832996(+) CCTGCC/TGACAG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs798523691,2
    C,F--46833038(+) GGGGGG/CACGCC 1 -- int12Minor allele frequency- C:0.18CSA WA 120
    rs124827971,2
    C,F,H--46833087(+) AGCCCC/TGTAGG 1 -- int12Minor allele frequency- T:0.25NA 8
    rs767017951,2
    C,F--46833114(+) CGTGAG/ATAAAA 1 -- int11Minor allele frequency- A:0.05EA 120
    rs1498933591,2
    C--46833150(+) TTTGTA/GCTGCT 1 -- int10--------
    rs1450015501,2
    C--46833235(+) CAGCCA/GCGCTA 1 -- int10--------
    rs1486761261,2
    --46833284(+) TCAACA/GCCCCT 1 -- int10--------
    rs1839723091,2
    --46833292(+) CCTGTC/TGCGGG 1 -- int10--------
    rs1860914601,2
    --46833370(+) CTCCCA/GCTACG 1 -- int10--------
    rs1399971021,2
    C--46833452(+) AGGCA-/GGTTCC 1 -- int10--------
    rs2020770621,2
    C--46833503(+) TGCTG-/CCTCTG 1 -- int10--------
    rs1909110711,2
    --46833596(+) CGTCCA/GCGCTA 1 -- int10--------
    rs1443981771,2
    --46833597(+) GTCCAC/TGCTAA 1 -- int10--------
    rs1136272711,2
    C,F--46833600(+) CACGCC/TAACCT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs719395371,2
    C--46833690(+) CTTGTGCCTGG/-
            
    GCCTT
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs608035101,2
    C--46833694(+) TGCCT-/GGGCCT
            
    TTGCA
    1 -- int10--------
    rs1826163821,2
    --46834026(+) CACCGC/TCTGGC 1 -- int10--------
    rs1166121491,2
    C,F--46834051(+) CCCAGC/GCTTGT 1 -- int11Minor allele frequency- G:0.03WA 118
    rs775816951,2
    C,F--46834090(+) CCTGGC/TTTTGC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs800453161,2
    C,F--46834115(+) TTGCTA/GGGAGG 1 -- int11Minor allele frequency- G:0.14WA 118
    rs285913051,2
    C,F--46834243(+) CCCCTC/TGGGGC 1 -- int10--------
    rs1921407621,2
    --46834244(+) CCCTCA/GGGGCA 1 -- int10--------
    rs1414156741,2
    C--46834307(+) GGCTCC/TAGTCC 1 -- int10--------
    rs28389071,2
    C,F,O,H--46834311(+) CCAGTC/GCGACC 1 -- int112Minor allele frequency- G:0.40NA NS EA WA 797
    rs1470418891,2
    --46834439(+) GTCTGA/GCATTT 1 -- int10--------
    rs1510274331,2
    --46834480(+) GGCTCA/GGACCC 1 -- int10--------
    rs1168982131,2
    C,F--46834495(+) GCCGAC/TTCTGC 1 -- int11Minor allele frequency- T:0.03EA 120
    rs771911501,2
    C,F--46834557(+) CCTCAC/TGGACA 1 -- int12Minor allele frequency- T:0.08WA NA 238
    rs1830453171,2
    --46834583(+) CAGAAA/GACAGC 1 -- int10--------
    rs1180179761,2
    C,F--46834623(+) GGACAC/TTAATG 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1409960391,2
    C--46834689(+) CACACA/C/GCATAG 1 -- int10--------
    rs1502071441,2
    C--46834741(+) GGACCC/TGTGAG 1 -- int10--------
    rs1129162661,2
    C--46834773(+) GGCTCA/GGGATC 1 -- int13Minor allele frequency- G:0.06CSA WA EA 240
    rs48190991,2
    C,F,A,H--46834814(+) GCCCCG/ACGTCA 1 -- int122Minor allele frequency- A:0.21NS EA WA NA CSA 2347
    rs1885649561,2
    --46834915(+) AGTGGG/TTTCCC 1 -- int10--------
    rs1931320891,2
    --46834952(+) GGCACC/TGTGAC 1 -- int10--------
    rs1122303711,2
    C--46835051(+) GCGGCG/ATGGTG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1388035511,2
    --46835108(+) TCTCAC/TCTGCG 1 -- int10--------
    rs72811381,2
    C,F--46835125(+) CACTCC/TGTGGG 1 -- int113Minor allele frequency- T:0.12NA WA CSA EA 375
    rs1494155321,2
    C--46835150(+) ATGTGG/TGCCGG 1 -- int10--------
    rs28389081,2
    C,F,O,A,H--46835194(+) GAATAT/CGAGCA 1 -- int114Minor allele frequency- C:0.27NA NS WA CSA EA 485
    rs1855396551,2
    --46835263(+) TCCTCA/GGCCTT 1 -- int10--------
    rs1457827901,2
    --46835304(+) TCTTCA/CGGTCC 1 -- int10--------
    rs48191001,2
    C,A,H--46835335(+) GCCCAG/CGGCAG 1 -- int16Minor allele frequency- C:0.07NS EA NA 514
    rs48191011,2
    C,F,A,H--46835361(+) CACCCG/AGGGCT 1 -- int114Minor allele frequency- A:0.25NS EA NA WA CSA 787
    rs1122551541,2
    C,F--46835380(+) AGGACC/TGGCTG 1 -- int12Minor allele frequency- T:0.04WA 120
    rs1384946221,2
    --46835432(+) GCGGCA/GGAGCG 1 -- int10--------
    rs1461850651,2
    --46835624(+) AGGTGC/TGAGCT 1 -- int10--------
    rs1483899621,2
    C--46835699(+) CTGGCA/GCTGCA 1 -- int10--------
    rs1416267681,2
    --46835702(+) GCGCTA/GCAGCC 1 -- int10--------
    rs1505463111,2
    --46835708(+) CAGCCA/GGGTGG 1 -- int10--------
    rs756885371,2
    C,F--46835789(+) AGGCAC/TGTGCC 1 -- int11Minor allele frequency- T:0.15EA 120
    rs1152543671,2
    F--46835866(+) AACACT/CGCGTG 1 -- int11Minor allele frequency- C:0.04WA 118
    rs1892593061,2
    --46835887(+) TATCTA/GGAATG 1 -- int10--------
    rs28389091,2
    C,F,O,A--46835896(+) TGCCTT/CGCCGG 1 -- int112Minor allele frequency- C:0.40NA WA CSA EA 388
    rs788338731,2
    C,F--46836080(+) GGATCG/TTGGCT 1 -- int11Minor allele frequency- T:0.02NA 120
    rs28389101,2
    C,F,O,A,H--46836228(+) ACACAT/CAGTCT 1 -- int115Minor allele frequency- C:0.30NA NS EA WA CSA 794
    rs789446251,2
    C,F--46836230(+) ACACAG/ATCTTG 1 -- int11Minor allele frequency- A:0.14WA 118
    rs1925252261,2
    --46836266(+) GGGGCC/TGGTGT 1 -- int10--------
    rs1842068801,2
    --46836286(+) CGGGGC/TACAGT 1 -- int10--------
    rs1888307091,2
    --46836296(+) TCTCCC/TCACGC 1 -- int10--------
    rs1812755671,2
    --46836339(+) GGACCA/GCGAGG 1 -- int10--------
    rs1124956831,2
    C,F--46836530(+) GGTCCA/GTCCTC 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs1130564931,2
    C,F--46836541(+) TGTGAA/CCTGGT 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs28389111,2
    C,F,H--46836598(+) TATTAT/GTCAGA 1 -- int118Minor allele frequency- G:0.30NA NS EA WA CSA 1038
    rs1397837151,2
    --46836654(+) GAGGTA/GCAGCC 1 -- int10--------
    rs130512071,2
    C,F--46836662(+) GCCTCT/GACTCT 1 -- int18Minor allele frequency- G:0.40NA WA EA 368
    rs765896141,2
    C,F--46836675(+) CACTTG/TATTGG 1 -- int13Minor allele frequency- T:0.12WA NA EA 358
    rs1862062471,2
    --46836676(+) ACTTGA/TTTGGA 1 -- int10--------
    rs130512281,2
    C,F--46836731(+) GCGCCC/TGCCCC 1 -- int110Minor allele frequency- T:0.28NA WA CSA EA 377
    rs1452756651,2
    --46836784(+) CATATC/GCTCGT 1 -- int10--------
    rs1451967331,2
    --46836797(+) TGCATA/TTCCTC 1 -- int10--------
    rs1131490911,2
    C,F--46836803(+) TCCTCA/G/TTCTGA 1 -- int11CSA 2
    rs1491512041,2
    --46836880(+) CGTGAC/GTTTTC 1 -- int10--------
    rs1432336221,2
    C--46837142(+) GTTTTG/TGTATT 1 -- int10--------
    rs789664791,2
    C,F--46837151(+) TTTCAC/TGTGGA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs567709751,2
    C--46837195(+) TCTTAG/ACCTCT 1 -- int13Minor allele frequency- A:0.17CSA NA EA 242
    rs1512838201,2
    C--46837242(+) TTCTGC/GCGCTT 1 -- int10--------
    rs119107881,2
    C,F,H--46837276(+) TCCACG/TGTAGT 1 -- int11Minor allele frequency- T:0.50NA 4
    rs765138931,2
    C,F--46837417(+) CTTCCG/AACTCG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs170047711,2
    C,F--46837432(+) TCTCAC/TGGGTG 1 -- int14Minor allele frequency- T:0.04NA WA 256
    rs340857191,2
    C--46837555(+) CATCCC/-AGGAC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs28389121,2
    C,F,O,A,H--46837590(+) ACAACA/GGACTG 1 -- int111Minor allele frequency- G:0.42NA WA CSA EA 384
    rs1458226631,2
    --46837611(+) GCTCTC/TGGCCG 1 -- int10--------
    rs1821932651,2
    --46837668(+) CTGTGG/TTCTGG 1 -- int10--------
    rs28389131,2
    C,F,O,A,H--46837709(+) CTCCCG/ATGAAG 1 -- int124Minor allele frequency- A:0.27NA NS EA WA CSA 2358
    rs1872685491,2
    --46837745(+) AAAACA/GCTAAG 1 -- int10--------
    rs28389141,2
    C,F,O,H--46837759(+) GGGGAG/CAATTG 1 -- int19Minor allele frequency- C:0.06NA NS EA WA 666
    rs1383782751,2
    --46837819(+) CAGGCC/TCCACC 1 -- int10--------
    rs1112678371,2
    C,F--46837831(+) ACAGCG/ACAGCT 1 -- int12Minor allele frequency- A:0.11CSA WA 120
    rs743962381,2
    C,F--46837855(+) GTCTCC/TGGCCT 1 -- int11Minor allele frequency- T:0.02NA 120
    rs1430603451,2
    C--46837872(+) TCTCCC/GCAGAC 1 -- int10--------
    rs48191041,2
    C,F--46837878(+) CAGACC/ACGTCT 1 -- int19Minor allele frequency- A:0.26NA WA CSA EA 370
    rs751474041,2
    C,F--46837930(+) AGGAAC/TCGAGA 1 -- int13Minor allele frequency- T:0.13WA NA EA 358
    rs1451870211,2
    C--46837959(+) TTAACA/GTGTGC 1 -- int10--------
    rs1389381111,2
    --46838003(+) CTGGCA/GTGGGG 1 -- int10--------
    rs3675662681,2
    C--46838084(+) ACTCCA/GGCTCT 1 -- int10--------
    rs1494663951,2
    --46838128(+) CTGAGC/TGGAGC 1 -- int10--------
    rs1908006461,2
    --46838176(+) TGCATC/TCCGGC 1 -- int10--------
    rs1807079461,2
    --46838193(+) CTGCCA/GAAGTG 1 -- int10--------
    rs1438601221,2
    --46838254(+) CCCCGA/GGCTGG 1 -- int10--------
    rs1850597221,2
    --46838316(+) TCAAGA/GCAGCC 1 -- int10--------
    rs787222341,2
    C,F--46838468(+) GCCTCC/TTTGCT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs557006111,2
    C,F--46838481(+) GCCTCG/AGGGTG 1 -- int16Minor allele frequency- A:0.44WA NA CSA EA 364
    rs1486436331,2
    --46838493(+) TCACCA/GGCGGT 1 -- int10--------
    rs284848001,2
    C--46838575(+) CTCACG/ATCTCT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1452331301,2
    C--46838633(+) CCTCAC/TGTCAC 1 -- int10--------
    rs110890021,2
    C,F,A,H--46838656(+) CAGGGC/AAGCGG 1 -- int16Minor allele frequency- A:0.40NA CSA WA EA 364
    rs1505998981,2
    --46838659(+) GGCAGA/CGGCAC 1 -- int10--------
    rs1396145931,2
    C--46838688(+) GGCTGC/TCTCTG 1 -- int10--------
    rs81287281,2
    C,F,A,H--46838701(+) TTAGCA/GTTGGG 1 -- int16Minor allele frequency- G:0.31NA WA EA 366
    rs81338851,2
    C,F,H--46838703(+) AGCGTC/TGGGTT 1 -- int110Minor allele frequency- T:0.16WA NA CSA EA 372
    rs1497801311,2
    --46838818(+) CCCCCA/GGACGG 1 -- int10--------
    rs285754221,2
    C--46838950(+) TGGACG/ACGAGG 1 -- int12Minor allele frequency- A:0.11CSA WA 120
    rs126276751,2
    C,F,H--46839075(+) TGACAT/GGCAAT 1 -- int111Minor allele frequency- G:0.08NS EA NA WA 1022
    rs1902066801,2
    --46839102(+) ATTCCA/GTGTAG 1 -- int10--------
    rs126272891,2
    C,H--46839113(+) TAAGGC/TGATGC 1 -- int14Minor allele frequency- T:0.11NA WA EA 360
    rs1456963611,2
    --46839119(+) GATGCC/TGTGTG 1 -- int10--------
    rs1448758111,2
    --46847059(+) AATATC/TTGGAC 1 -- int10--------
    rs28389241,2
    C,F,O--46847085(+) GCCACG/ACTGGG 1 -- int15Minor allele frequency- A:0.05NA WA 266
    rs1807033041,2
    --46847142(+) CCATCA/GCAGCC 1 -- int10--------
    rs1859123011,2
    --46847221(+) CTTCTC/TCCCAC 1 -- int10--------
    rs1479552021,2
    --46847259(+) CTGGCA/GTTGAA 1 -- int10--------
    rs1176273101,2
    C,F--46847266(+) TGAATC/TAGGAG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs796771091,2
    C--46847286(+) GGCCCC/TTAGTA 1 -- int14Minor allele frequency- T:0.06CSA WA NA EA 360
    rs1136233091,2
    C,F--46847330(+) CTGGCG/CCACCA 1 -- int11Minor allele frequency- C:0.50WA 2
    rs350155751,2
    C,F--46847417(+) GCTCCG/ACCTCC 1 -- int16Minor allele frequency- A:0.12NA CSA WA EA 364
    rs1900290531,2
    --46847432(+) GGCAGC/GCCCCC 1 -- int10--------
    rs1812034691,2
    --46847508(+) CCACGA/GCGGGC 1 -- int10--------
    rs1871192211,2
    --46847729(+) AGAACC/TAGCGG 1 -- int10--------
    rs28389251,2
    C,F,O,H--46847759(+) GAATGC/TGCCGG 1 -- int116Minor allele frequency- T:0.04NA NS EA WA 1535
    rs1455319851,2
    --46847772(+) ACTGGC/TGATGA 1 -- int10--------
    rs749597331,2
    C--46847817(+) ACACCC/TGGGGC 1 -- int13Minor allele frequency- T:0.07CSA WA EA 240
    rs1488418851,2
    --46847825(+) GGCCTA/GGATGA 1 -- int10--------
    rs1454800811,2
    C--46847870(+) TCCTGA/GGAGAT 1 -- int10--------
    rs72785971,2
    C--46847899(+) GAGCCA/GGGAGG 1 -- int10--------
    rs1379756491,2
    C--46847932(+) GCCAAC/TGCAGC 1 -- int10--------
    rs748753491,2
    C--46847962(+) GCGCCG/AGCCAA 1 -- int14Minor allele frequency- A:0.06CSA WA NA EA 360
    rs1113420571,2
    F--46847973(+) GGCCCG/ATCGGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1449237761,2
    --46847975(+) CCCGTC/TGGCAC 1 -- int10--------
    rs801060451,2
    C--46847979(+) TCGGCA/CCCACC 1 -- int13Minor allele frequency- C:0.08CSA WA EA 240
    rs1138974611,2
    F--46848023(+) CTCTGC/TGGGCA 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs119113191,2
    C,F,H--46848071(+) TCCGGC/TGCTCC 1 -- int16Minor allele frequency- T:0.01NS EA NA WA 532
    rs1834726951,2
    --46848143(+) GGCCTC/TGGGCC 1 -- int10--------
    rs119113271,2
    C,F,H--46848156(+) AAAGAC/TGCAGC 1 -- int116Minor allele frequency- T:0.10NS EA NA WA 2030
    rs1862954951,2
    --46848173(+) GGAACC/TGGGAG 1 -- int10--------
    rs1898953521,2
    --46848232(+) TGACCC/TGGCGT 1 -- int10--------
    rs28389261,2
    C,F,O--46848238(+) GGCGTG/ACAGGG 1 -- int15Minor allele frequency- A:0.06NA WA 278
    rs81267571,2
    C,F,A,H--46848282(+) CTGGGA/GTCAGG 1 -- int122Minor allele frequency- G:0.40NS EA NA WA CSA 2349
    rs1414294371,2
    --46848310(+) AGGACC/TGAGGC 1 -- int10--------
    rs130462321,2
    C,F,H--46848320(+) CCACCA/GGTTTC 1 -- int110Minor allele frequency- G:0.10EA NS NA CSA WA 536
    rs28389271,2
    C,F,O,H--46848326(+) GTTTCC/TACCCT 1 -- int121Minor allele frequency- T:0.21NA NS EA WA 2365
    rs28389281,2
    C,F,O--46848372(+) GGATTC/TTTTAA 1 -- int15Minor allele frequency- T:0.05NA WA 278
    rs1830170561,2
    --46848431(+) AAAGCA/GAACAA 1 -- int10--------
    rs81349511,2
    C,F,A,H--46848439(+) caattC/Tggtga 1 -- int111Minor allele frequency- T:0.09NS EA NA CSA WA 1214
    rs81270581,2
    C,F,A,H--46848499(+) agaacA/Tttcac 1 -- int110Minor allele frequency- T:0.04NS EA NA WA 1212
    rs743946021,2
    C,F--46848507(+) CACACG/ACCGGA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs81270741,2
    C,F,A--46848531(+) gggccA/Gtcacg 1 -- int12Minor allele frequency- G:0.09CSA WA 120
    rs1875913221,2
    C--46848536(+) ATCACA/GCAGCC 1 -- int10--------
    rs1508201861,2
    --46848545(+) CCACCA/GCCCGG 1 -- int10--------
    rs117027821,2
    C,F,H--46848589(+) GGATCG/AGCGGT 1 -- int114Minor allele frequency- A:0.08NS EA NA 1586
    rs1463150861,2
    --46848591(+) TCGGC-/GGGGTTC 1 -- int10--------
    rs2016225451,2
    C--46848642(+) TGTTTC/TGGGCT 1 -- int10--------
    rs1167342021,2
    C,F--46848808(+) TGCTTT/GCTTTC 1 -- int11Minor allele frequency- G:0.04WA 118
    rs355003581,2
    C--46848831(+) TTTTT-/TAATTT 1 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs99746561,2
    C--46848832(+) TTTTTA/TATTTG 1 -- int12Minor allele frequency- T:0.25NA 4
    rs99743611,2
    C,F,A--46848841(+) TGAGAC/TGGAGT 1 -- int17Minor allele frequency- T:0.25NA WA CSA 131
    rs1382271441,2
    --46848881(+) GGTGCA/GATCTC 1 -- int10--------
    rs1438978651,2
    C--46848887(+) ATCTCC/GGCTCA 1 -- int10--------
    rs1131891351,2
    C,F--46848963(+) TAGGCA/GCGCCA 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs1179195161,2
    F--46848964(+) AGGCGC/TGCCAC 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1164391151,2
    C,F--46848965(+) GGCGCG/ACCACC 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1828231721,2
    --46848973(+) ACCCCA/GCCCGG 1 -- int10--------
    rs1408756931,2
    --46848984(+) CCAATG/TTTTTT 1 -- int10--------
    rs1448218201,2
    --46849023(+) ATGTTA/GGCCAG 1 -- int10--------
    rs1448560791,2
    --46849028(+) GGCCAC/GGATGG 1 -- int10--------
    rs1485822971,2
    C--46849030(+) CCAGGA/CTGGTC 1 -- int10--------
    rs1874415321,2
    --46849058(+) TGATCC/TGCCCG 1 -- int10--------
    rs1918782261,2
    --46849096(+) CAGGCA/GTGAGC 1 -- int10--------
    rs1420704061,2
    C--46849216(+) CAAGAG/TGAAAG 1 -- int10--------
    rs20268871,2
    C,F,A,H--46849281(+) GGTGAC/TGGTCG 1 -- int118Minor allele frequency- T:0.49EA NS NA WA CSA 701
    rs1847389011,2
    --46849285(+) ATGGTC/TGCTGT 1 -- int10--------
    rs1462802971,2
    C--46849323(+) AGGAA-/GGGGCA 1 -- int10--------
    rs58442361,2
    C--46849331(+) CAGTGC/-CCACA 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1894820991,2
    --46849362(+) CGGACA/GTTGAT 1 -- int10--------
    rs1930920161,2
    --46849383(+) CGCCCA/GTTCCA 1 -- int10--------
    rs561918031,2
    C--46849395(+) CATTCA/GGTCAC 1 -- int10--------
    rs72806721,2
    C,F,H--46849433(+) GCTGCA/GTAGAA 1 -- int15Minor allele frequency- G:0.03NS EA WA 530
    rs1178286981,2
    C,F--46849501(+) TGGGGC/ATGGAG 1 -- int11Minor allele frequency- A:0.02NA 120
    rs28389291,2
    C,F,O,A--46849560(+) GCGGCA/GGGATC 1 -- int112Minor allele frequency- G:0.41NA WA CSA EA 406
    rs28389301,2
    C,F,O,H--46849651(+) GTGAAA/GGCCAG 1 -- int18Minor allele frequency- G:0.01NA NS EA 539
    rs1410592141,2
    --46849741(+) TGCCCA/GCCTTG 1 -- int10--------
    rs72759911,2
    C,F,H--46849749(+) TTGGTT/CCAGCA 1 -- int18Minor allele frequency- C:0.09NS EA NA WA 668
    rs1447532921,2
    --46849759(+) AGAACA/GGCTCC 1 -- int10--------
    rs170047721,2
    C,F,H--46849777(+) ACAGCG/AGTGCC 1 -- int17Minor allele frequency- A:0.02NA NS EA 550
    rs772978241,2
    F--46849811(+) AAGCGC/GGGTCA 1 -- int10--------
    rs1436667781,2
    --46849853(+) TCTCAC/TTGGGG 1 -- int10--------
    rs786724351,2
    C,F--46849917(+) GAAGCG/AGGGTC 1 -- int13Minor allele frequency- A:0.11CSA NA EA 242
    rs1845885471,2
    --46849997(+) TTGGGG/TGCCCC 1 -- int10--------
    rs2020808591,2
    --46850003(+) CCCCC-/TATCTC 1 -- int10--------
    rs1150805771,2
    C,F--46850015(+) CTAGCG/ACCCTC 1 -- int12Minor allele frequency- A:0.07WA EA 238
    rs1154302471,2
    F--46850037(+) CCCCCG/ATCTCC 1 -- int13Minor allele frequency- A:0.09WA NA EA 358
    rs1891150181,2
    C--46850068(+) CCTGCA/GTGTGC 1 -- int10--------
    rs28389311,2
    O,H--46850079(+) TGTGTC/GCATGA 1 -- int15Minor allele frequency- G:0.01NA NS EA 428
    rs286741661,2
    C,F--46850081(+) TGTCCA/GTGAAG 1 -- int13Minor allele frequency- G:0.11WA NA EA 358
    rs1814559321,2
    --46850105(+) TGGGGC/GCCCCC 1 -- int10--------
    rs1855952071,2
    --46850131(+) CTCTCA/GCCCTC 1 -- int10--------
    rs170047731,2
    C,F,H--46850194(+) CTCTCG/ACCTTC 1 -- int110Minor allele frequency- A:0.05NA NS EA CSA WA 667
    rs1890868201,2
    --46850228(+) GTGGTC/TAGAGC 1 -- int10--------
    rs1480738601,2
    --46850265(+) TCCCCA/GGTGCC 1 -- int10--------
    rs1151336011,2
    C,F--46850310(+) TTCATA/GGGCTA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs173380761,2
    C,F,H--46850351(+) CACCCG/AGGTCC 1 -- int19Minor allele frequency- A:0.04NA EA NS 672
    rs1439174191,2
    C--46850505(+) GGTCCA/GGTTAC 1 -- int10--------
    rs791449541,2
    C,F--46850526(+) GGAGCG/ACGTGG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1472857151,2
    --46850575(+) ATGGCA/GCGTCT 1 -- int10--------
    rs763834721,2
    F--46850581(+) CGTCTC/TGGCCC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1814788661,2
    C--46850582(+) GTCTCA/GGCCCG 1 -- int10--------
    rs1391217851,2
    --46850700(+) CTCGTC/TCACCA 1 -- int10--------
    rs1432512021,2
    --46850748(+) GATCAC/TGAGGC 1 -- int10--------
    rs766944831,2
    C,F--46850749(+) ATCACA/GAGGCT 1 -- int10--------
    rs733849751,2
    C,F--46850752(+) ACGAGG/ACTCTG 1 -- int11Minor allele frequency- A:0.05WA 118
    rs1860636491,2
    --46850824(+) GAACAC/TGTAGA 1 -- int10--------
    rs1912241561,2
    --46850875(+) AAGTCC/TGTAGA 1 -- int10--------
    rs1838006201,2
    C--46850876(+) AGTCCC/GTAGAA 1 -- int10--------
    rs1154913841,2
    C--46850925(+) ACGGGC/G/TGGGCC 1 -- int10--------
    rs1861398141,2
    C--46850931(+) GGGCCA/GAGCAG 1 -- int10--------
    rs1509560671,2
    C--46850988(+) TTTGC-/TGGTTT
            
    GAGGC
    1 -- int10--------
    rs1906596561,2
    --46851008(+) GGTGAA/CGCTCC 1 -- int10--------
    rs787548191,2
    C,F--46851018(+) CTGTGC/TGGGAG 1 -- int13Minor allele frequency- T:0.09WA NA EA 358
    rs792200431,2
    C,F--46851046(+) ATAGCG/AGCTTA 1 -- int11Minor allele frequency- A:0.08WA 118
    rs1832785001,2
    --46851094(+) CTGTGC/TTCTCC 1 -- int10--------
    rs1172656071,2
    C,F--46851112(+) GGCGAC/TGGACA 1 -- int11Minor allele frequency- T:0.06EA 120
    rs64177271,2
    C--46851341(+) GGAGGG/TGGGCA 1 -- int10--------
    rs65182431,2
    C,F--46851450(+) AGGACC/TCGGCG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs72819601,2
    C--46851483(+) GGACCA/CGGCGG 1 -- int10--------
    rs1830455191,2
    --46851593(+) GGAGGG/TCCCAG 1 -- int10--------
    rs1137342161,2
    C--46851673(+) ATTTGG/AGCACA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1131209301,2
    C,F--46851700(+) GCGGAC/TGGTCT 1 -- int12Minor allele frequency- T:0.03CSA WA 120
    rs1872914931,2
    --46851747(+) CTCTCA/GGCTCC 1 -- int10--------
    rs1129917131,2
    C,F--46851856(+) CGGCTA/GCTCTC 1 -- int10--------
    rs563273271,2
    C,F--46851898(+) AAGCTA/GCTTTC 1 -- int18Minor allele frequency- G:0.46WA NA CSA EA 368
    rs799400641,2
    C,F--46851974(+) CCTGGG/ACGGTG 1 -- int11Minor allele frequency- A:0.05NA 120
    rs762005891,2
    C,F--46852094(+) CCCAGC/GAGGGC 1 -- int11Minor allele frequency- G:0.21EA 120
    rs1118121171,2
    C--46852151(+) TCAGAGCTGGG/-
            
    GCTGG
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1932882161,2
    --46852215(+) CAGTGA/GGAGTC 1 -- int10--------
    rs99757851,2
    C,F,A--46852242(+) GCAGAC/TGCCGC 1 -- int18Minor allele frequency- T:0.41NA CSA WA EA 366
    rs99835901,2
    C,F--46852243(+) CAGATG/ACCGCT 1 -- int13Minor allele frequency- A:0.23WA NA EA 358
    rs1391366021,2
    C--46852247(+) TGCCGC/TTGAGG 1 -- int10--------
    rs99842351,2
    C,F--46852259(+) ACCCCC/TCACTT 1 -- int17Minor allele frequency- T:0.43WA NA CSA EA 366
    rs99780151,2
    C,F,A--46852289(+) TCCATT/CGATTG 1 -- int17Minor allele frequency- C:0.42WA CSA NA EA 366
    rs99780291,2
    C,F,A--46852314(+) TCAGGT/CGGATA 1 -- int18Minor allele frequency- C:0.41WA NA CSA EA 368
    rs1854238981,2
    --46852329(+) CCTAGA/CGGCCT 1 -- int10--------
    rs65182441,2
    C,H--46852529(+) AGAGCG/ATCTGG 1 -- int112Minor allele frequency- A:0.00NA WA CSA EA 374
    rs119089761,2
    C,H--46852559(+) AGCGCG/AGCAGG 1 -- int12Minor allele frequency- A:0.06NA WA 122
    rs119090291,2
    C,A,H--46852687(+) GGTGGG/CACATG 1 -- int15Minor allele frequency- C:0.18NA CSA WA EA 362
    rs1140658561,2
    C,F--46852758(+) TCCCTC/TGGTAC 1 -- int12Minor allele frequency- T:0.02WA NA 238
    rs49905611,2
    C,F--46852785(+) ACCCTC/TCACCC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs75103811,2
    C,F,A,H--46852824(+) GCCTGC/TGCCAA 1 -- int115Minor allele frequency- T:0.36EA NS NA WA CSA 671
    rs1879550191,2
    --46852856(+) AAATGG/TCCCAC 1 -- int10--------
    rs81295391,2
    C,F,A,H--46852978(+) CTCTTC/GGAAAC 1 -- int116Minor allele frequency- G:0.23NS EA NA WA CSA 1204
    rs1174562241,2
    F--46853032(+) ATTTCG/AAGAGG 1 -- int11Minor allele frequency- A:0.01EA 120
    rs1131032071,2
    F--46853035(+) TCGAGC/AGGGTC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs556845331,2
    C,F--46853110(+) GGACGC/TGCTGG 1 -- int15Minor allele frequency- T:0.12WA NA EA 364
    rs1162091481,2
    F--46853155(+)