COL18A1 Gene

Aliases
for COL18A1 gene

Previous GC identifers: GC21P043334 GC21P045681 GC21P045649 GC21P032201

Summaries
for COL18A1 gene

Genomic Views
for COL18A1 gene

Proteins
for COL18A1 gene

3 PDB 3D structures from and Proteopedia for COL18A1:

1BNL (3D)        3HON (3D)        3HSH (3D)    

Explore the universe of human proteins at neXtProt for COL18A1: NX_P39060

Post-translational modifications:

	EMD Millipore Purified and/or Recombinant COL18A1 Protein
	R&D Systems Recombinant & Natural Proteins for COL18A1 (Endostatin)
	Enzo Life Sciences proteins for COL18A1
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for COL18A1
	GenScript Purified and Recombinant Proteins for COL18A1
	Novus Biologicals COL18A1 Proteins
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for COL18A1
	Uscn Proteins for COL18A1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of COL18A1
	R&D Systems Antibodies for COL18A1 (Endostatin)
	Browse OriGene Antibodies OriGene Custom Antibody Services for COL18A1
	GenScript Superior Antibodies for COL18A1
	Novus Biologicals COL18A1 Antibodies
	Search for Antibodies for COL18A1 at Abcam
	Uscn Antibodies for COL18A1
	ThermoFisher Antibody for COL18A1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for COL18A1 (Endostatin)         (see all)
	GenScript Custom Assay Services for COL18A1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for COL18A1

Protein Domains /
Families
for COL18A1 gene

ProtoNet protein and cluster: P39060

Function
for COL18A1 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): COL18A1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL18A1
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate COL18A1:
		hsa-miR-9 hsa-miR-526b hsa-miR-516a-3p hsa-miR-516b* hsa-miR-578 hsa-miR-3159
		SwitchGear 3'UTR luciferase reporter plasmid: COL18A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL18A1 (see all 4) OriGene shRNA RFP: COL18A1 OriGene siRNA: COL18A1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL18A1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for COL18A1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COL18A1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COL18A1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): COL18A1 (NM_030582)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL18A1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL18A1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COL18A1
		Search LifeMap BioReagents cell lines for COL18A1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL18A1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Col18a1)

Pathways & Interactions
for COL18A1 gene

	Super-pathway	contained gene-specific pathways
1	Integrin Pathway	Integrin Pathway 1.00 UPA-UPAR Pathway 0.51 FAK1 Signaling 0.67 Transendothelial Migration of Leukocytes 0.38 GnRH Signaling 0.56 Inhibition of Angiogenesis by TSP1 0.37
2	Collagen formation	Collagen formation 1.00 Extracellular matrix organization 0.54 Collagen biosynthesis and modifying enzymes 0.74 Secretion of collagens 0.49 Assembly of collagen fibrils and other multimeric structures 0.65
3	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
4	Degradation of the extracellular matrix	Degradation of the extracellular matrix 1.00 Degradation of collagen 0.79
5	Blood Coagulation Cascade	Blood Coagulation Cascade 1.00 Intrinsic Prothrombin Activation Pathway 0.96

1 EMD Millipore Pathway for COL18A1

Selected targets of p53

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL18A1

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

2 BioSystems Pathways for COL18A1

	FOXA1 transcription factor network
	Direct p53 effectors

5/8        Reactome Pathways for COL18A1

	Endostatin degradation by cathepsins
	Extracellular matrix organization
	Secretion of collagens
	Collagen biosynthesis and modifying enzymes
	Assembly of collagen fibrils and other multimeric structures

1         Kegg Pathway  (Kegg details for COL18A1)

Protein digestion and absorption

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

Drugs & Compounds
for COL18A1 gene

Transcripts
for COL18A1 gene

Expression
for COL18A1 gene

COL18A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATCCTCAA

8 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeCiliary Marginal ZoneCiliary Marginal Zone Cells			Neural Ectoderm
	KidneyUreteric BudUreteric Bud Cells			Kidney
	Neural TubeNeural TubeSpinal Neural Tube Cells			Neural Ectoderm
	PancreasDorsal Pancreatic BudImmature Beta Progenitor Cells			Pancreas
	PancreasVentral Pancreatic BudImmature Beta Progenitor Cells			Pancreas
	TestisSeminiferous TubulesSertoli cells			Testis
	BrainMeninges			Brain
	Spinal CordPresumptive Spinal Cord			Spinal Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 4 LifeMap Cells
	Name			Category
	PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
	PureStem™ progenitor U31 (Embryonic Progenitor Cell)
	PureStem™ progenitor W8 (Embryonic Progenitor Cell)
	Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COL18A1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COL18A1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL18A1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL18A1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL18A1

Orthologs
for COL18A1 gene

Paralogs
for COL18A1 gene

Paralogs for COL18A1 gene

COL15A1²  

2 SIMAP similar genes for COL18A1 using alignment to 6 protein entries:     COIA1_HUMAN (see all proteins):

COLQ    COL7A1

COL18A1 for paralogs           About GeneDecksing

Genomic Variants
for COL18A1 gene

10/3074 NCBI SNPs in COL18A1 are shown (see all 3074)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs124833771,2	C,F,H,	pathogenic	46931109(+)	CCTTTG/AACGGC	4	/N /D	mis1 ese3		31		NA NS EA MN EU	3505
rs124826841,2	C,H	--	32297339(+)	gtgtgT/Gagtgt	1	--	int1		2		WA NA	4
rs1911348801,2		--	46823185(+)	CCCTGC/TCCCAG	1	--	us2k1		0	--	--	--	--
rs1467271841,2		--	46823307(+)	ATGGGG/TTGGGT	1	--	us2k1		0	--	--	--	--
rs1403673981,2		--	46823339(+)	GGCAGA/GTGAGA	1	--	us2k1		0	--	--	--	--
rs124825791,2	H	--	46823369(+)	CTGCAC/GTGCAG	1	--	us2k1		4		NS EA	416
rs786019091,2		--	46823375(+)	TGCAGG/CGTTAA	1	--	us2k1		2		CSA WA	120
rs758842651,2		--	46823382(+)	TTAATG/TGACAG	1	--	us2k1		2		CSA WA	120
rs1833174191,2		--	46823512(+)	ACAGAA/CACACA	1	--	us2k1		0	--	--	--	--
rs1396933531,2	C,	--	46823544(+)	GAGAG-/ACAT     GCACACACATG	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for COL18A1 (46825052 - 46933634 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for COL18A1
     7 CNVs: 50788 61984 53305 53268 39306 103116 50787
     1 Indel: 103117
Human Gene Mutation Database (HGMD): COL18A1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COL18A1

DNA2.0 Custom Variant and Variant Library Synthesis for COL18A1

Disorders / Diseases
for COL18A1 gene

20/61 diseases for COL18A1

3 Novoseek disease relationships for COL18A1 gene    About this table

Publications
for COL18A1 gene

PubMed articles for COL18A1 gene, integrated from 9 sources (see all 144) (see top 10): (articles sorted by number of sources associating them with COL18A1)

Utopia: connect your pdf to the dynamic world of online information

1. Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure. (PubMed id 10942434)^{1, 2, 3, 9} Sertie A.L....Passos-Bueno M.R. (2000)
2. Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21. (PubMed id 8188291)^{1, 2, 3, 9} Oh S.P....Olsen B.R. (1994)
3. Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin. (PubMed id 14695535)^{1, 2, 9} Menzel O.... Guipponi M. (2004)
4. CNS malformations in Knobloch syndrome with splice mutation in COL18A1 gene. (PubMed id 17546652)^{1, 3, 9} Keren B....Verloes A. (2007)
5. Endostatin polymorphism 4349G/A(D104N) is not associated with aggressiveness of disease in prostate [corrected] cancer. (PubMed id 15735323)^{1, 4} Li H.C....Lu B. (2005)
6. Genotyping and functional analysis of the D104N variant of human endostatin. (PubMed id 15662127)^{1, 4} Macpherson G.R....Figg W.D. (2004)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. Assocation of endostatin D104N with leukemia. (PubMed id 12693719)^{1, 4} Liu T.C....Chang J.G. (2003)
9. Characterization of the human type XVIII collagen gene and proteolytic processing and tissue location of the variant containing a frizzled motif. (PubMed id 14614989)^{1, 2} Elamaa H.... Pihlajaniemi T. (2003)
10. A polymorphism in the angiogenesis inhibitor, endostatin, in multiple myeloma. (PubMed id 12479859)^{1, 4} Ortega M.M....Lima C.S. (2003)
11. Inhibition effect in vitro of purified endostatin expressed in Pichia pastoris. (PubMed id 11517600)^{1, 2} Feng Y.... Ma Q.J. (2001)
12. A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma. (PubMed id 11606364)^{1, 2} Iughetti P.... Passos-Bueno M.R. (2001)
13. The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
14. Zinc-dependent dimers observed in crystals of human endostatin. (PubMed id 9724722)^{1, 2} Ding Y.-H.... Wiley D.C. (1998)
15. Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific differences in the expression of the corresponding transcripts. (PubMed id 9503365)^{1, 2} Saarela J.... Pihlajaniemi T. (1998)
16. A gene which causes severe ocular alterations and occipital encephalocele (Knobloch syndrome) is mapped to 21q22.3. (PubMed id 8776601)^{1, 3} Sertie A.L....Passos-Bueno M.R. (1996)
17. Novel pathogenic mutations and skin biopsy analysis in Knobloch syndrome. (PubMed id 19390655)^{1, 9} Suzuki O....Passos-Bueno M.R. (2009)
18. A pooling-based genome-wide analysis identifies new p otential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS). (PubMed id 19961619)^{1, 9} Castro-Giner F....de Cid R. (2009)
19. A high risk of occurrence of sporadic breast cancer in individuals with the 104NN polymorphism of the COL18A1 gene. (PubMed id 16807676)^{1, 9} Lourenco G.J....Lima C.S. (2006)
20. Molecular analysis of collagen XVIII reveals novel mutations, presence of a third isoform, and possible genetic heterogeneity in Knobloch syndrome. (PubMed id 12415512)^{1, 9} Suzuki O.T....Passos-Bueno M.R. (2002)
21. Correlations between serum levels of vascular endothel ial growth factor and endostatin with clinical pathological characteristics of p atients with gastrointestinal cancers. (PubMed id 22819906)¹ Li M....Zhao Y. (2012)
22. A 3' UTR SNP in COL18A1 is associated with susceptibil ity to HBV related hepatocellular carcinoma in Chinese: three independent case-c ontrol studies. (PubMed id 22461898)¹ Wu X....Liu Y. (2012)
23. Inhibition of Wnt/b-catenin signaling by a soluble col lagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8. (PubMed id 22303445)¹ Hendaoui I....Musso O. (2012)
24. Transcription expression and clinical significance of vascular endothelial growth factor mRNA and endostatin mRNA in pleural effusions of patients with lung cancer. (PubMed id 22431315)¹ Chen Y....Wu G.P. (2012)
25. A role for collagen XXIII in cancer cell adhesion, anc horage-independence and metastasis. (PubMed id 21963851)¹ Spivey K.A....Zetter B.R. (2012)
26. Multiple loci influencing hippocampal degeneration ide ntified by genome scan. (PubMed id 22745009)¹ Melville S.A....Farrer L.A. (2012)
27. Serum endostatin levels correlate with enhanced extrac ellular matrix degradation and poor patients' prognosis in bladder cancer. (PubMed id 21815140)¹ Szarvas T....Ergun S. (2012)
28. Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition. (PubMed id 22733742)¹ Sunshine S.B....Rupnick M. (2012)
29. Osteopontin and endostatin concentrations in periphera l blood of patients with adrenal tumors undergoing unilateral adrenalectomy. (PubMed id 21968021)¹ Stepien T....Komorowski J. (2011)
30. Microdeformation of three-dimensional cultured fibrob lasts induces gene expression and morphological changes. (PubMed id 21233699)¹ Lu F....Orgill D.P. (2011)
31. Cysteine cathepsins S and L modulate anti-angiogenic activities of human endostatin. (PubMed id 21896479)¹ Veillard F....Lalmanach G. (2011)
32. Lack of collagen XVIII long isoforms affects kidney p odocytes, whereas the short form is needed in the proximal tubular basement mem brane. (PubMed id 21193414)¹ Kinnunen A.I....Pihlajaniemi T. (2011)
33. A DNA pooling-based case-control study of myopia cand idate genes COL11A1, COL18A1, FBN1, and PLOD1 in a Chinese population. (PubMed id 21527992)¹ Yip S.P....Yap M.K. (2011)
34. Effect of peritoneal dialysis on expression of vascula r endothelial growth factor, basic fibroblast growth factor and endostatin of th e peritoneum in peritoneal dialysis patients. (PubMed id 21771176)¹ Gao D....Liu Z.S. (2011)
35. Systemic blood osteopontin, endostatin, and E-selecti n concentrations after vertical banding surgery in severely obese adults. (PubMed id 21486700)¹ Komorowski J....Stepien H. (2011)
36. Effects of recombinant human endostatin on peritoneal angiogenesis in peritoneal dialysis rats. (PubMed id 21457400)¹ Zhao Z.Z....Liang X.H. (2011)
37. Deletion of the basement membrane heparan sulfate pro teoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. (PubMed id 21085708)¹ Bishop J.R....Moulton K.S. (2010)
38. Expression of endostatin mediated by a novel non-vira l delivery system inhibits human umbilical vein endothelial cells in vitro. (PubMed id 19585274)¹ Zhang C....Wu C. (2010)
39. Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (PubMed id 20346360)¹ Roberts K.E....Fallon M.B. (2010)
40. Transglutaminase-2: a new endostatin partner in the e xtracellular matrix of endothelial cells. (PubMed id 20156196)¹ Faye C....Ricard-Blum S. (2010)
41. The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets. (PubMed id 20063989)¹ Bambace N.M....Holmes C.E. (2010)
42. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)¹ Zhang X....Wu X. (2010)
43. Prognostic relevance of collagen XVIII expression in metastatic gastric carcinoma. (PubMed id 20361288)¹ Lee K.S....Hong Y.S. (2010)
44. Expression of b-FGF and endostatin and their clinical significance in human osteosarcoma. (PubMed id 22009965)¹ Xu C.J....Liu X.L. (2010)
45. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)¹ Guey L.T....Malats N. (2010)
46. Network organization of the human autophagy system. (PubMed id 20562859)¹ Behrends C....Harper J.W. (2010)
47. Genetic variations in angiogenesis pathway genes asso ciated with clinical outcome in localized gastric adenocarcinoma. (PubMed id 19622587)¹ Lurje G....Lenz H.J. (2010)
48. Lack of collagen XVIII/endostatin exacerbates immune- mediated glomerulonephritis. (PubMed id 20616167)¹ Hamano Y....Ueda S. (2010)
49. Homozygosity mapping through whole genome analysis id entifies a COL18A1 mutation in an Indian family presenting with an autosomal re cessive neurological disorder. (PubMed id 19160445)¹ PaisA!n-Ruiz C....Houlden H. (2009)
50. Combined endostatin and TRAIL gene transfer suppresses human hepatocellular carcinoma growth and angiogenesis in nude mice. (PubMed id 19223770)¹ Zhang Y....Sun W.S. (2009)
51. Serum angiogenic factors in patients with neuroendocr ine tumors of abdominal organs. (PubMed id 20396759)¹ Polikarpova S.B....Davidov M.I. (2009)
52. The heparin binding motif of endostatin mediates its interaction with receptor nucleolin. (PubMed id 19877579)¹ Fu Y....Luo Y. (2009)
53. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)¹ Hosgood H.D....Lan Q. (2009)
54. [Clinical significance of serum levels of endostatin in patients with clear cell renal cell carcinoma] (PubMed id 19615205)¹ Guan K.P....Li C.L. (2009)
55. The first draft of the endostatin interaction network . (PubMed id 19542224)¹ Faye C....Ricard-Blum S. (2009)
56. Sustained delivery of endostatin improves the efficacy of therapy in Lewis lung cancer model. (PubMed id 19084038)¹ Wu J....Hu Y. (2009)
57. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)¹ Shen M....Lan Q. (2009)
58. Airway concentrations of angiopoietin-1 and endostatin in ventilated extremely premature infants are decreased after funisitis and unbalanced with bronchopulmonary dysplasia/death. (PubMed id 19127216)¹ Thomas W....Speer C.P. (2009)
59. Crystal structure of human collagen XVIII trimerizati on domain: A novel collagen trimerization Fold. (PubMed id 19631658)¹ Boudko S.P....BAochinger H.P. (2009)
60. Polymorphism in endostatin, an angiogenesis inhibitor, and prostate cancer risk and survival: A prospective study. (PubMed id 19431146)¹ Mucci L.A....Kantoff P.W. (2009)
61. Endostatin, placental growth factor, and fibroblast g rowth factors-1 and -2 in the sera of patients with primary osteosarcomas. (PubMed id 20027339)¹ Babkina I.V....Kushlinsky N.E. (2009)
62. Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels. (PubMed id 19298526)¹ Nguyen T.M....Ramakrishnan S. (2009)
63. Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. (PubMed id 19074676)¹ Sodha N.R....Sellke F.W. (2009)
64. Expression and secretion of endostatin in thyroid cancer. (PubMed id 18818971)¹ Hoffmann S....Zielke A. (2008)
65. High level of endostatin in epididymal epithelium: protection against primary malignancies in this organ? (PubMed id 18478248)¹ Tilki D....Ergun S. (2008)
66. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
67. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. (PubMed id 18987736)² Ley T.J.... Wilson R.K. (2008)
68. A polymorphism in the angiogenesis inhibitor, endostatin, in lung cancer susceptibility. (PubMed id 18054814)¹ Zambon L....Lima C.S. (2008)
69. Association between endometriosis and polymorphisms in endostatin and vascular endothelial growth factor and their serum levels in Korean women. (PubMed id 17482599)¹ Kim J.G....Choi Y.M. (2008)
70. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)¹ Hosgood H.D....Lan Q. (2008)
71. COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C > T in its 'frizzled' motif is associated with obesity in diabetes type 2 patients. (PubMed id 18345385)¹ Errera F.I....Passos-Bueno M.R. (2008)
72. A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling. (PubMed id 18382662)¹ Quelard D....Musso O. (2008)
73. Expression pattern and circulating levels of endostatin in patients with pancreas cancer. (PubMed id 18360823)¹ Ohlund D....Sund M. (2008)
74. Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis. (PubMed id 18381814)¹ Yuan S....Luo Y. (2008)
75. Contributions of Zn(II)-binding to the structural stability of endostatin. (PubMed id 17544408)¹ Han Q....Luo Y. (2007)
76. Candidate gene and locus analysis of myopia. (PubMed id 17653045)¹ Mutti D.O....Zadnik K. (2007)
77. Endogenous endostatin inhibits choroidal neovascularization. (PubMed id 17526870)¹ Marneros A.G....Olsen B.R. (2007)
78. D104N polymorphism in endostatin, an angiogenesis inhibitor, in acute and chronic myeloid leukaemia. (PubMed id 17067672)¹ Nascimento H....Lima C.S. (2007)
79. Endostatin variations in childhood acute lymphoblastic leukaemia--comparison with basic fibroblast growth factor and vascular endothelial growth factor. (PubMed id 17011029)¹ Schneider P....Vannier J.P. (2007)
80. Endostatin binding to ovarian cancer cells inhibits peritoneal attachment and dissemination. (PubMed id 18006826)¹ Yokoyama Y....Ramakrishnan S. (2007)
81. Endostatin gene variation and protein levels in breast cancer susceptibility and severity. (PubMed id 17587451)¹ Balasubramanian S.P....Reed M.W. (2007)
82. Pretreatment serum endostatin as a prognostic indicator in metastatic gastric carcinoma. (PubMed id 16998835)¹ Woo I.S....Chung I.S. (2006)
83. Deficiency of disulfide bonds facilitating fibrillogen esis of endostatin. (PubMed id 16269408)¹ He Y....Luo Y. (2006)
84. Endostatin/collagen XVIII accumulates in patients with traumatic brain injury. (PubMed id 16866623)¹ Deininger M.H....Schluesener H.J. (2006)
85. Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic mice. (PubMed id 16793908)¹ Schaffhauser B....Christofori G. (2006)
86. Protein kinase B inhibits endostatin-induced apoptosis in HUVECs. (PubMed id 16466644)¹ Kang H.Y....Kim H.Y. (2006)
87. [Inhibitory effect of endostatin mediated by lipofect in on transplanted ovarian cancer] (PubMed id 16008891)¹ Wei Z.T....Sun W.S. (2005)
88. Endostatin competes with bFGF for binding to heparin-like glycosaminoglycans. (PubMed id 15985216)¹ Reis R.C....Coelho-Sampaio T. (2005)
89. Endostatin's heparan sulfate-binding site is essential for inhibition of angiogenesis and enhances in situ binding to capillary-like structures in bone explants. (PubMed id 15694132)¹ Gaetzner S....Felbor U. (2005)
90. Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma. (PubMed id 15605080)¹ Hu T.H....Tai M.H. (2005)
91. The influence of biomechanical parameters on the expression of VEGF and endostatin in the bone and joint system. (PubMed id 16320826)¹ Pufe T....Tillmann B. (2005)
92. Serum endostatin levels in patients with lung carcinoma. (PubMed id 16358965)¹ Swidzinska E....Chyczewska E. (2005)
93. Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases. (PubMed id 15950618)¹ Heljasvaara R....Pihlajaniemi T. (2005)
94. Increased serum levels of endostatin in patients with idiopathic pulmonary fibrosis. (PubMed id 16025479)¹ Sumi M....Sekizawa K. (2005)
95. Endostatin inhibits nitric oxide and diminishes VEGF and collagen XVIII in squamous carcinoma cells. (PubMed id 15540202)¹ Hebert C....Sauk J.J. (2005)
96. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
97. E-selectin is required for the antiangiogenic activity of endostatin. (PubMed id 15148373)¹ Yu Y....Milstone D.S. (2004)
98. Overexpression of collagen XVIII is associated with poor outcome and elevated levels of circulating serum endostatin in non-small cell lung cancer. (PubMed id 15328173)¹ Iizasa T....Fujisawa T. (2004)
99. Inhibition of orthotopic human bladder tumor growth by lentiviral gene transfer of endostatin. (PubMed id 15014038)¹ Kikuchi E....Bochner B.H. (2004)
100. An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells. (PubMed id 14973128)¹ Wickstrom S.A....Keski-Oja J. (2004)
101. Endostatin/collagen XVIII--an inhibitor of angiogenesis--is expressed in cartilage and fibrocartilage. (PubMed id 15464359)¹ Pufe T....Tillmann B.N. (2004)
102. Raised plasma endostatin levels correlate inversely with breast cancer angiogenesis. (PubMed id 14732364)¹ Teh S.H....O'Higgins N. (2004)
103. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
104. Hypoxia simultaneously inhibits endostatin production and stimulates vascular endothelial growth factor production by cultured human endometrial stromal cells. (PubMed id 15374730)¹ Nasu K....Miyakawa I. (2004)
105. Expression of collagen XVIII and MMP-20 in developing teeth and odontogenic tumors. (PubMed id 15296943)¹ Vaananen A....Salo T. (2004)
106. Human endostatin gene transfer, either naked or with liposome, has the same inhibitory effect on growth of mouse liver tumor cells in vivo. (PubMed id 15334690)¹ Ma C.H....Sun W.S. (2004)
107. Elevated serum concentrations of the angiogenesis inhibitor endostatin in preeclamptic women. (PubMed id 14519482)¹ Hirtenlehner K....Knofler M. (2003)
108. Human endostatin-derived synthetic peptides possess potent antiangiogenic properties in vitro and in vivo. (PubMed id 12581742)¹ Cattaneo M.G....Vicentini L.M. (2003)
109. Prolactin antagonist-endostatin fusion protein as a targeted dual-functional therapeutic agent for breast cancer. (PubMed id 12839947)¹ Beck M.T....Chen W.Y. (2003)
110. Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. (PubMed id 12682293)¹ Sudhakar A.... Kalluri R. (2003)
111. High serum level of endostatin in multiple myeloma at diagnosis but not in the plateau phase after treatment. (PubMed id 14514474)¹ Urbanska-Rys H. and Robak T. (2003)
112. Pleural mesothelial cell (PMC) defense mechanisms against malignancy. (PubMed id 14760864)¹ Nasreen N....Antony V.B. (2003)
113. Circulating proangiogenic cytokines and angiogenesis inhibitor endostatin in untreated patients with chronic lymphocytic leukemia. (PubMed id 12857600)¹ Gora-Tybor J....Robak T. (2003)
114. Endostatin binds to the catalytic domain of matrix metalloproteinase-2. (PubMed id 12023034)¹ Lee S.J....Lee S.T. (2002)
115. The production of the endostatin precursor collagen XVIII in head and neck carcinomas is modulated by CBP2/Hsp47. (PubMed id 12174873)¹ Ollins G.J....Sauk J.J. (2002)
116. Increased levels of tissue endostatin in human malignant gliomas. (PubMed id 12231538)¹ Morimoto T....Yamaguchi N. (2002)
117. Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed in specialized basement membranes. (PubMed id 11937714)¹ Tomono Y....Ninomiya Y. (2002)
118. Aberrant neuronal and paracellular deposition of endostatin in brains of patients with Alzheimer's disease. (PubMed id 12486154)¹ Deininger M.H....Meyermann R. (2002)
119. Collagen XVIII: a novel heparan sulfate proteoglycan associated with vascular amyloid depositions and senile plaques in Alzheimer's disease brains. (PubMed id 12408231)¹ van Horssen J....Verbeek M.M. (2002)
120. Accumulation of endostatin/collagenXVIII in brains of patients who died with cerebral malaria. (PubMed id 12458056)¹ Deininger M.H....Schluesener H.J. (2002)
121. Laminin modulates morphogenic properties of the collagen XVIII endostatin domain. (PubMed id 12237301)¹ Javaherian K....Lo K.M. (2002)
122. Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia. (PubMed id 12209593)¹ Glenjen N....Bruserud O. (2002)
123. Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. (PubMed id 11815623)¹ Hanai J....Sukhatme V.P. (2002)
124. Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1. (PubMed id 12029087)¹ Kim Y.M....Kwon Y.G. (2002)
125. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
126. Interaction of endostatin with integrins implicated in angiogenesis. (PubMed id 11158588)¹ Rehn M....Vuori K. (2001)
127. Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes. (PubMed id 11911017)¹ Ergun S....Folkman J. (2001)
128. Cell surface glypicans are low-affinity endostatin receptors. (PubMed id 11336704)¹ Karumanchi S.A....Sukhatme V.P. (2001)
129. Hypoxia down-regulates endostatin production by human microvascular endothelial cells and pericytes. (PubMed id 11700031)¹ Wu P....Yamamoto H. (2001)
130. High serum endostatin levels in Down syndrome: implications for improved treatment and prevention of solid tumours. (PubMed id 11781696)¹ Zorick T.S....Passos-Bueno M.R. (2001)
131. Secreted cathepsin L generates endostatin from collagen XVIII. (PubMed id 10716919)¹ Felbor U....Mothes W. (2000)
132. Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins. (PubMed id 10544250)¹ Sasaki T....Timpl R. (1999)
133. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. (PubMed id 9008168)¹ O'Reilly M.S....Folkman J. (1997)
134. Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins. (PubMed id 8183893)¹ Oh S.P....Olsen B.R. (1994)
135. Characterization of human collagen XVIII promoter 2: interaction of Sp1, Sp3 and YY1 with the regulatory region and a SNP that increases transcription in hepatocytes. (PubMed id 16229994)⁹ Armelin-Correa L.M....Passos-Bueno M.R. (2005)
136. The promoter of the long variant of collagen XVIII, the precursor of endostatin, contains liver-specific regulatory elements. (PubMed id 11093745)⁹ Lietard J....Clement B. (2000)
137. Persistence of fetal vasculature in a patient with Knobloch syndrome: potential role for endostatin in fetal vascular remodeling of the eye. (PubMed id 15465551)⁹ Duh E.J....Goldberg M.F. (2004)
138. A phenotypic variant of Knobloch syndrome. (PubMed id 18484314)⁹ Williams T.A....Ainsworth J.R. (2008)
139. Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets. (PubMed id 20212451)⁹ Gadd S....Perlman E.J. (2010)
140. Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells. (PubMed id 19145252)⁹ Kirwan R.P....O'Brien C.J. (2009)

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