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COL18A1 Gene

protein-coding   GIFtS: 66

GC21P045649
collagen, type XVIII, alpha 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for COL18A1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase, and/or 9Nature:405,311-319 and CroW21)
About This Section
Aliases
FLJ27325 2
FLJ34914 2
KNO 2
KNO1 2, 5
MGC74745 2
OTTHUMP00000115472 2
OTTHUMP00000115473 2
endostatin 2
Descriptions
alpha 1 type XVIII collagen 2
antiangiogenic agent 2
collagen, type XVIII, alpha 1 2
human type XVIII collagen 9
multi-functional protein MFP 2
External Ids
HGNC: 21951
Entrez Gene: 807812
UniProtKB: P390603
Ensembl: ENSG000001828717
Search outside databases for aliases for COL18A1 gene

Previous GC identifers: GC21P043334 GC21P045681

Summaries
for COL18A1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for COL18A1:
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins,
extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains)
interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type
XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are
associated with Knobloch syndrome. The main features of this syndrome involve retinal
abnormalities, so type XVIII collagen may play an important role in retinal structure and in
neural tube closure. Alternatively spliced transcript variants encoding different isoforms have
been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060
Function: Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit
angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling

Gene Wiki entry for COL18A1 (Collagen%2C_type_XVIII%2C_alpha_1)

Genomic Location
for COL18A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
COL18A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P045649:   GeneLoc Nature:405,311-319
Start:
 45,649,480 bp from pter       32,384,934 bp from centromere
End:
 45,758,062 bp from pter 32,443,158 bp from centromere
Size:
 108,583 bases 58,225 bases
Orientation:
 plus strand plus strand
RefSeq DNA sequence:
NC_000021.7  NT_011515.11  

Whole chromosome sequencing:
cDNA sequence: AF018081
genomic clones: P310E12 BAC-53I10

Proteins
for COL18A1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060 (See protein sequence)
Recommended Name: Collagen alpha-1(XVIII) chain precursor  
Size: 1754 amino acids; 178188 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
PDB structures from and Proteopedia :
1BNL (3D)    
Secondary accessions: Q58EX6 Q6RZ39 Q6RZ40 Q6RZ41 Q8N4S4 Q8WXI5 Q96T70 Q9UK38 Q9Y6Q7 Q9Y6Q8
Alternative promoter usage, Alternative splicing: 3 isoforms:  P39060-3   P39060-1   P39060-2   

Post-translational modifications:

  • Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or
    all of the chains1


    • REFSEQ proteins (3 alternative transcripts): 
    NP_085059.2  NP_569711.2  NP_569712.2  


    ENSEMBL proteins: 
    ENSP00000383201 ENSP00000383191 ENSP00000347665 ENSP00000352798 ENSP00000339118 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for COL18A1  
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for COL18A1
    Recombinant Proteins from Abcam (Endostatin)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005581 collagen TAS10942434
    GO:0005634 nucleus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    GO:0005794 Golgi apparatus IDA18029348
    About this table

    Antibodies for COL18A1: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of COL18A1
    Sigma-Aldrich Antibodies for COL18A1
    R&D Systems Antibodies for COL18A1 (Endostatin)
    Antibodies from Abcam (Endostatin), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for COL18A1

    Assays for COL18A1: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of COL18A1
    R&D Systems ELISAs for COL18A1 (Endostatin)         (see all)
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for COL18A1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR010363 DUF959_COL18_N
     IPR010515 Endostatin
     IPR008160 Collagen


       GeneDecks  COL18A1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P39060

    ProtoNet protein and cluster: P39060

    5 Blocks protein families:
    IPB001791 Laminin G
    IPB003129 Thrombospondin
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat
    IPB010515 Collagenase NC10 and endostatin


    UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060
    Similarity: Belongs to the multiplexin collagen family
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 1 TSP N-terminal (TSPN) domain

    Gene Function
    for COL18A1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (COL18A1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_130444

                  Applied Biosystems Silencer® siRNAs for COL18A1

                  Sigma-Aldrich siRNA and siRNA Panels for COL18A1  
                         Sigma-Aldrich shRNA Panels and shRNA for COL18A1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_030582
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_030582
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_030582 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_130444

    UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060
    Function: COLA18A probably plays a major role in determining the retinal structure as well as in
    the closure of the neural tube
    Function: Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit
    angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling

    Genatlas biochemistry entry for COL18A1:
    collagen,type XVIII,alpha 1,multiplexin family with interrupted helical domain

    4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Col18a1):

    othertumorigenesisvision/eye

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201 extracellular matrix structural constituent IEA--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for COL18A1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for COL18A1
     Selected targets of p53

       GeneDecks  COL18A1 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  COL18A1  (Your Favorite Gene powered by Ingenuity) 
     Dendritic Cell Maturation

       GeneDecks  COL18A1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  COL18A1 


    5/29 Interacting proteins for COL18A1 (ENSP000003527983) via UniProtKB, MINT, and/or STRING (see all 29 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPC4ENSP000003598643STRING (score=.939)
    GPC1ENSP000002640393STRING (score=.934)
    CRYZENSP000003393993STRING (score=.899)
    ESR1ENSP000002062493STRING (score=.899)
    FOXA1ENSP000002504483STRING (score=.899)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155 cell adhesion IEA--
    GO:0007601 visual perception TAS10942434
    GO:0008285 negative regulation of cell proliferation TAS9008168
    GO:0009887 organ morphogenesis TAS10942434
    About this table

    Drugs & Compounds
    for COL18A1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for COL18A1

    Transcripts
    for COL18A1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (COL18A1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_130444

                  Sigma-Aldrich siRNA and siRNA Panels for COL18A1  
                         Sigma-Aldrich shRNA Panels and shRNA for COL18A1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_030582  NM_130444  NM_130445  

    REFSEQ mRNAs for COL18A1 gene (3 alternative transcripts): 

    NM_030582.3   NM_130444.2   NM_130445.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_030582  NM_130444  NM_130445  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_030582
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_030582
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_030582 

    Additional cDNA sequence: 

    AF018081.1 AF018082.1 AF184060.1 AF333246.1 AF333247.1 AF416592.1 AK098216.1 AK130835.1 
    AK311062.1 BC033715.1 BC063833.1 CR622901.1 

    19 DOTS entries:

    DT.447571  DT.92001135  DT.91912586  DT.95302146  DT.121139495  DT.101985460  DT.100039632  DT.95220877 
    DT.99986442  DT.92436231  DT.100034049  DT.100039626  DT.40116647  DT.100039627  DT.91744920  DT.95090195 
    DT.95349603  DT.100798481  DT.99955859 

    24/195 AceView cDNA sequences (see all 195 ):

    BQ003811 AI076853 AA350510 AW298029 AA731506 AW137045 AI660746 AI858077 
    CR602937 BE881571 AA350512 T28473 NM_194255 BU680493 F02853 AI204685 
    R86040 AA069352 CA426982 AI074505 AA913825 AA743360 BG106854 AK127669 

    highest scoring ESTs for COL18A1:

    AF018081 AA009986 AA009987 AA063600 AA099280 AA099281 AA156716 AA156812 AA190539 AA193615 

    Unigene Cluster for COL18A1:

    Collagen, type XVIII, alpha 1
    Hs.517356  [show with all ESTs]
    Unigene Representative Sequence: NM_130444


    GeneLoc Exon Structure

    5 Ensembl transcripts including schematic representations:
    ENST00000400347  ENST00000400337  ENST00000355480  ENST00000359759  ENST00000342220  

    Expression
    for COL18A1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    COL18A1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for COL18A1

    1 / 2 / 3

    5 probe-sets matching COL18A1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37653_at2, 3 U95-A 1 0.31 1.00 1.00 1.00 AF018081 1.00 1.00 1.00 1

    		209082_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF018081 1.00 1.00 1.00 1

    		209081_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_030582 0.60 1.00 0.82 1

    		209082_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		209081_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  COL18A1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TAATCCTCAA

    SOURCE GeneReport for Unigene cluster: Hs.517356

    Expression variation in blood from EXPOLDB for COL18A1

    UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060
    Tissue specificity: Present in multiple organs with highest levels in liver, lung and kidney

    Orthologs
    for COL18A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for COL18A1 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 COL18A11   -- collagen, type XVIII, alpha 1 98.41(n)
    98.54(a)    		 474050  XM_531500.2  XP_531500.2 
    cow
    (Bos taurus)    		 COL18A11   -- collagen, type XVIII, alpha 1 78.95(n)
    78.21(a)    		 508076  XM_584804.3  XP_584804.3 
    rat
    (Rattus norvegicus)    		 Col18a11   -- collagen, type XVIII, alpha 1 77.08(n)
    78.94(a)    		 85251  XM_241632.4  XP_241632.4 
    mouse
    (Mus musculus)    		 Col18a11, 5 10 (41.30 cM)5
    		 collagen, type XVIII, alpha 11, 5 77.79(n)1
    79.92(a)1    		 128221  NM_009929.21  NP_034059.21 
     AC0076415  AC0557775  (see all 38)
    chicken
    (Gallus gallus)    		 COL18A11   -- collagen, type XVIII, alpha 1 65.27(n)
    63.61(a)    		 373978  NM_204164.1  NP_989495.1 
    About this table        Species with no ortholog for COL18A1

    ENSEMBL Gene Tree for COL18A1

    Paralogs
    for COL18A1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for COL18A1 gene
    COL15A12  

    SNPs/Variants
    for COL18A1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060
    Polymorphism: There is an association between a polymorphism in position 1675 and prostate cancer.
    Heterozygous Asn-1675 individuals have a 2.5 times increased chance of developing prostate cancer
    as compared with homozygous Asp-1675 individuals


    10/969 NCBI SNPs in COL18A1 are shown (see all 969 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 285)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 21 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs78671,2
    		A,C,F,O45757080(+) GGGAAA/GCCGTG 3 -- ut31 ese310Minor allele frequency- G:0.45NA EA MN 2276
    --
    rs117024941,2
    		A,C,F,H45700734(+) CGGGCG/ACACTG 3 T/A mis1 int1 ese34Minor allele frequency- A:0.18EU EA WA 412
    rs74991,2
    		A,C,F,H45756756(+) GATGCA/GGATGG 3 -- ut31 ese310Minor allele frequency- G:0.49MN NA EU EA WA 946
    rs7555481,2
    		A,C,F45699173(+) AGGAGT/GATGCA 2 -- ng51 int11Minor allele frequency- G:0.30MN 184
    rs170047851,2
    		C,F,H45757046(+) ACCACC/GGCTCG 3 -- ut31 ese312Minor allele frequency- N:0.00NA EU EA WA 1056
    rs170047841,2
    		C,F,H45757017(+) TGCCCT/CGTGCA 3 -- ut31 ese37Minor allele frequency- C:0.05NA EU EA WA 562
    rs81991,2
    		A,C,F45756811(+) GGAGCA/GGCCGG 3 -- ut31 ese35Minor allele frequency- G:0.41EA MN NA 1620
    rs124833771,2
    		C,F,H45755537(+) CCTTTG/AACGGC 3 N/D mis1 ese311Minor allele frequency- A:0.04EU EA WA NA 978
    --
    rs170047861,2
    		F,H45757592(+) TGAGCG/CCCAGG 3 -- ut31 ese37Minor allele frequency- C:0.03NA EU EA WA 542
    rs22364531,2
    		H45713055(+) CTCACG/AGGGCC 3 Q/R mis1 ese34Minor allele frequency- A:0.00EU EA WA 410
    About this table

    HapMap Linkage Disequilibrium images for COL18A1 (up to first 250kb)

    Disorders & Mutations
    for COL18A1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 120328   disorders: 267750  

    UniProtKB/Swiss-Prot: COIA1_HUMAN, P39060

  • Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an
    autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration
    with retinal detachment, macular abnormalities and occipital encephalocele

    • 2 Novoseek disease relationships for COL18A1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    knobloch syndrome 98.68 6 19390655 (2), 14695535 (1), 17546652 (1), 18484314 (1) (see all 5)
    occipital encephalocele 82.90 1 15857886 (1)
    About this table

    Human Gene Mutation Database: COL18A1
    Genetic Association Database: COL18A1
    Human Genome Epidemiology Navigator: COL18A1 (11 documents)
    Tumor Gene Database: COL18A1
    Breast Cancer Gene Database: COL18A1

    Medical News
    for COL18A1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for COL18A1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/101 PubMed articles for COL18A1 gene (see all 101 ):

    Search for COL18A1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing COL18A1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 80781 HGNC: 2195 AceView: SLC19A1 Ensembl:ENSG00000182871 euGenes: HUgn80781
    ECgene: COL18A1 H-InvDB: COL18A1

    Other Databases showing COL18A1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing COL18A1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for COL18A1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.genetests.org/query?gene=COL18A1

    Licensable Technologies
    for COL18A1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for COL18A1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for COL18A1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for COL18A1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for COL18A1 Antibodies for COL18A1
     Explore super-pooled esiRNAs Proteins for COL18A1
     Lentivirus-delivered shRNAs for COL18A1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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