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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COL16A1 Gene

protein-coding GIFtS: 54
GCID: GC01M032117

collagen, type XVI, alpha 1

Explore 2 diseases affiliated with
COL16A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Collagen, Type XVI, Alpha 1¹ ²
447AA²
Alpha 1 Type XVI Collagen²
Collagen Alpha-1(XVI) Chain²
Collagen XVI, Alpha-1 Polypeptide²

External Ids:	HGNC: 2193¹	Entrez Gene: 1307²	Ensembl: ENSG00000084636⁷	OMIM: 120326⁵	UniProtKB: Q07092³

Export aliases for COL16A1 gene to outside databases

Previous GC identifers: GC01M031925 GC01M031102 GC01M031544 GC01M031620 GC01M031786 GC01M031890 GC01M030235

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COL16A1:

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated

collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming

collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type

XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: COGA1_HUMAN, Q07092

Function: Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell

spreading and alterations in cell morphology

Gene Wiki entry for COL16A1 (Collagen, type XVI, alpha 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COL16A1 gene promoter:
ISGF-3 GATA-3 MIF-1 IRF-1 Nkx2-5 PPAR-alpha PPAR-gamma1 POU2F1 HOXA5 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COL16A1 promoter sequence

Search SABiosciences Chromatin IP Primers for COL16A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL16A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35-p34 Ensembl cytogenetic band: 1p35.2 HGNC cytogenetic band: 1p35-p34

COL16A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL16A1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M032117: view genomic region (about GC identifiers)

Start:	32,117,848 bp from pter	End:	32,169,920 bp from pter
Size:	52,073 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COGA1_HUMAN, Q07092 (See protein sequence)

Recommended Name: Collagen alpha-1(XVI) chain precursor

Size: 1604 amino acids; 157751 Da

Subunit: Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1

binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3

Subcellular location: Secreted, extracellular space, extracellular matrix

Developmental stage: Transiently elevated expression during gestation, and decrease at term

Secondary accessions: Q16593 Q59F89 Q71RG9

Alternative splicing: 2 isoforms: Q07092-1 Q07092-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COL16A1: NX_Q07092

Post-translational modifications:

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains¹

Glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07092

COL16A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001847.3

ENSEMBL proteins:

ENSP00000362776 ENSP00000390281 ENSP00000411457 ENSP00000362772 ENSP00000362771

ENSP00000271069

Reactome Protein details: Q07092
Human Recombinant Protein Products:

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	Novus Biologicals COL16A1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005597	collagen type XVI	TAS	1284248
GO:0005788	endoplasmic reticulum lumen	TAS	--

COL16A1 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COL16A1 for domains About GeneDecksing

3 InterPro domains/families:

IPR001791 Laminin_G

IPR008160 Collagen

IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry Q07092

ProtoNet protein and cluster: Q07092

3 Blocks protein families:

IPB003129 Thrombospondin

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: COGA1_HUMAN, Q07092

Domain: This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten

non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either

elastic or flexible

Similarity: Belongs to the fibril-associated collagens with interrupted helices (FACIT) family

Similarity: Contains 8 collagen-like domains

Similarity: Contains 1 laminin G-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: COGA1_HUMAN, Q07092

Function: Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell

spreading and alterations in cell morphology

Genatlas biochemistry entry for COL16A1:

collagen,type XVI,alpha 1,with features of fibril associated collagen with interrupted helices (?FACIT variant)

miRNA Products:		OriGene 3'-UTR Clone: COL16A1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL16A1
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		hsa-miR-181c hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-181a hsa-miR-181d hsa-miR-1184 hsa-miR-513b

		SwitchGear 3'UTR luciferase reporter plasmid: COL16A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL16A1 (see all 7) OriGene shRNA RFP: COL16A1 OriGene siRNA: COL16A1
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for COL16A1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL16A1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005178	integrin binding	IDA	16754661
GO:0005515	protein binding	IPI	15165854

COL16A1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Collagen formation

	Collagen formation	1.00			Extracellular matrix organization	0.54
	Collagen biosynthesis and modifying enzymes	0.74			Secretion of collagens	0.49

Degradation of the extracellular matrix

Degradation of the extracellular matrix

1.00

Degradation of collagen

0.79

Blood Coagulation Cascade

Blood Coagulation Cascade

1.00

Intrinsic Prothrombin Activation Pathway

0.96

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL16A1 (see all 15)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

5/6 Reactome Pathways for COL16A1 (see all 6)

	Extracellular matrix organization
	Secretion of collagens
	Collagen biosynthesis and modifying enzymes
	Degradation of the extracellular matrix
	Collagen formation

COL16A1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for COL16A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/42 Interacting proteins for COL16A1 (Q07092^{2, 3} ENSP00000362776⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GFAP	P14136²^,³, ENSP00000253408⁴	MINT-6743170 I2D: score=1 STRING: ENSP00000253408
COL4A1	P02462², ENSP00000364979⁴	MINT-6743179 STRING: ENSP00000364979
SUMO1	P63165³, ENSP00000376076⁴	I2D: score=1 STRING: ENSP00000376076
COL10A1	ENSP00000243222⁴	STRING: ENSP00000243222
COL11A1	ENSP00000351163⁴	STRING: ENSP00000351163

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IDA	16754661
GO:0007229	integrin-mediated signaling pathway	TAS	16754661
GO:0007565	female pregnancy	TAS	1284248
GO:0030198	extracellular matrix organization	TAS	--
GO:0071230	cellular response to amino acid stimulus	IEA	--

COL16A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COL16A1
Search CenterWatch for drugs/clinical trials and news about COL16A1 / COGA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COL16A1 gene:

NM_001856.3

Unigene Cluster for COL16A1:

Collagen, type XVI, alpha 1

Hs.368921 [show with all ESTs]

Unigene Representative Sequence: NM_001856

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000373672(uc001btj.1 uc001btk.1) ENST00000489280 ENST00000488128

ENST00000488897 ENST00000461217 ENST00000440437 ENST00000466829 ENST00000470799

ENST00000482910 ENST00000462481 ENST00000468459 ENST00000479100 ENST00000458715

ENST00000373668(uc001btl.4) ENST00000474000 ENST00000482478 ENST00000529928

ENST00000373667

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL16A1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate COL16A1 (see all 12):
		hsa-miR-181c hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-181a hsa-miR-181d hsa-miR-1184 hsa-miR-513b

		SwitchGear 3'UTR luciferase reporter plasmid: COL16A1 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL16A1

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		GenScript: all cDNA clones in your preferred vector: COL16A1 (NM_001856)
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Additional cDNA sequence:

AB209571.1 AF370368.1 BC064839.1 BC118655.1 M92642.1 S57132.1 X14963.1 X15038.1

16 DOTS entries:

DT.444233 DT.99990364 DT.95298015 DT.40231039 DT.75130869 DT.433295 DT.95154274 DT.100645420

DT.121442523 DT.75192513 DT.91829406 DT.92425382 DT.100750193 DT.313921 DT.91754176 DT.92425383

24/106 AceView cDNA sequences (see all 106):

BQ001266 BG697379 AA770215 CA394098 X15038 BU733264 BC064839 CB215004

BP363100 AI656575 CR611324 AA682251 BU182098 BF223892 BF058423 BM707745

X14963 BF434543 CF455572 BM664872 BF718643 AI686616 AI589349 BQ575853

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for COL16A1 (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^
SP1:																																	-
SP2:
SP3:
SP4:
SP5:

ExUns:	23	^	24	^	25	^	26	^	27	^	28	^	29a	·	29b	^	30	^	31a	·	31b	^	32	^	33
SP1:
SP2:													-
SP3:													-
SP4:													-
SP5:

ECgene alternative splicing isoforms for COL16A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COL16A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGGGCCTT

About this image

COL16A1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephros

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

See COL16A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COL16A1

SOURCE GeneReport for Unigene cluster: Hs.368921

UniProtKB/Swiss-Prot: COGA1_HUMAN, Q07092

Tissue specificity: In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils, whereas in

territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen fibrils in

association with other collagens (at protein level). In the placenta, where it is found in the amnion, a membranous

tissue lining the amniotic cavity. Within the amnion, it is found in an acellular, relatively dense layer of a complex

network of reticular fibers. Also located to a fibroblast layer beneath this dense layer. Exists in tissues in

association with other types of collagen

SABiosciences Expression via Pathway-Focused PCR Array including COL16A1:

Extracellular Matrix & Adhesion Molecules in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL16A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for COL16A1 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC430477¹	collagen alpha-1(XVI) chain-like	67.39(n) 69.16(a)		430477 XM_003642581.1 XP_003642629.1
lizard (Anolis carolinensis)	Reptilia	COL16A1⁶	--	69(a)	1 ↔ 1	GL343308.1(448389-593713)
zebrafish (Danio rerio)	Actinopterygii	LOC100535782¹	collagen alpha-1(XIX) chain-like	55.34(n) 56.02(a)		100535782 XM_003200625.1 XP_003200673.1
worm (Caenorhabditis elegans)	Secernentea	dpy-5⁶ col-182⁶ (see all 11)	COLlagen family member (col-182) (see all 11)	30(a) 30(a) (see all 11)	possible ortholog possible ortholog (see all 11)	I(5432161-5433059) X(12636085-12636988)

ENSEMBL Gene Tree for COL16A1 (if available)
TreeFam Gene Tree for COL16A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for COL16A1 gene

COL4A6² COL19A1² COL11A2² COL4A5² COL24A1² COL4A4² COL5A3² COL1A1²

COL4A2² COL5A2² COL5A1² COL4A3² COL22A1² COL7A1² COL1A2² COL27A1²

COL3A1² COL2A1² COL4A1² COL11A1²

6 SIMAP similar genes for COL16A1 using alignment to 6 protein entries: COGA1_HUMAN (see all proteins):

SFTPD COL17A1 COLEC11 FCN2 COL7A1 MARCO

COL16A1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78313233^1,2	C	--	32117373(+)	`AGGTTC/TCATCT`	1	--	ds500¹		0	--	--	--	--
rs77190555^1,2	C	--	32117374(+)	`GGTTCC/TATCTC`	1	--	ds500¹		0	--	--	--	--
rs138807915^1,2		--	32117388(+)	`TCCCAA/GAGAAG`	1	--	ds500¹		0	--	--	--	--
rs114071566^1,2		--	32117429(+)	`GCCTGC/TCTTCT`	1	--	ds500¹		0	--	--	--	--
rs74358333^1,2	C,	--	32117709(+)	`CTTGAG/CAGAAG`	1	--	ds500¹		2		NA EA	122
rs2139539^1,2	C,F,O,A,H,	--	32117779(+)	`GATCCC/TGAGGA`	1	--	ds500¹		30		NA NS EA CSA WA	2918
rs181842391^1,2		--	32117807(+)	`GCCCCC/TATCCA`	1	--	ds500¹		0	--	--	--	--
rs141442362^1,2	C,	--	32117822(+)	`AATCT-/CACAGCA`	1	--	ds500¹		0	--	--	--	--
rs186187190^1,2		--	32117826(+)	`TCACAC/GCACCA`	1	--	ds500¹		0	--	--	--	--
rs79928805^1,2		--	32118065(+)	`GCTGCA/GGCACC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for COL16A1 (32117848 - 32169920 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for COL16A1
3 CNVs: 9879 2304 3287

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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COL16A1 for disorders           About GeneDecksing

OMIM gene information: 120326    OMIM disorders: --

2 diseases for COL16A1:    About MalaCards

oral cancer glioblastoma

Human Genome Epidemiology (HuGE) Navigator: COL16A1 (3 documents)

Export disorders for COL16A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for COL16A1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with COL16A1)

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Cloning and chromosomal location of human alpha 1(XVI) collagen. (PubMed id 1631157)^{1, 2, 3} Pan T.-C.... Chu M.-L. (1992)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains. (PubMed id 16754661)^{1, 2} Eble J.A.... Grassel S. (2006)
Molecular structure and interaction of recombinant human type XVI collagen. (PubMed id 15165854)^{1, 2} Kassner A.... Grassel S. (2004)
Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils. (PubMed id 12782140)^{1, 2} Kassner A.... Grassel S. (2003)
Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells. (PubMed id 9022684)^{1, 2} Grassel S.... Chu M.-L. (1996)
Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain. (PubMed id 7882999)^{1, 2} Tillet E.... Timpl R. (1995)
Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments. (PubMed id 1284248)^{1, 2} Yamaguchi N.... Nagai Y. (1992)
Epidermolysis bullosa - a group of skin diseases with different causes but commonalities in gene expression. (PubMed id 22716248)¹ Knaup J....Krammer B. (2012)
Induction of type XVI collagen expression facilitates proliferation of oral cancer cells. (PubMed id 21251976)¹ Ratzinger S....Bauer R.J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1307	HGNC: 2193	AceView: COL16A1	Ensembl:ENSG00000084636	euGenes: HUgn1307
ECgene: COL16A1	H-InvDB: COL16A1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for COL16A1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COL16A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for COL16A1 gene:
Search GeneIP for patents involving COL16A1

GeneCards and IP:
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COL16A1 Gene

collagen, type XVI, alpha 1

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COL16A1 Gene

collagen, type XVI, alpha 1

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