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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COL16A1 Gene

protein-coding   GIFtS: 55
GCID: GC01M032117

Collagen, Type XVI, Alpha 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Collagen, Type XVI, Alpha 11 2
447AA2
Alpha 1 Type XVI Collagen2
Collagen Alpha-1(XVI) Chain2
Collagen XVI, Alpha-1 Polypeptide2

External Ids:    HGNC: 21931   Entrez Gene: 13072   Ensembl: ENSG000000846367   OMIM: 1203265   UniProtKB: Q070923   

Export aliases for COL16A1 gene to outside databases

Previous GC identifers: GC01M031925 GC01M031102 GC01M031544 GC01M031620 GC01M031786 GC01M031890 GC01M030235


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COL16A1 Gene:
This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated
collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming
collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of
type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion. (provided by
RefSeq, Jul 2008)

GeneCards Summary for COL16A1 Gene: 
COL16A1 (collagen, type XVI, alpha 1) is a protein-coding gene. Diseases associated with COL16A1 include epidermolysis bullosa, and oral cancer, and among its related super-pathways are Collagen biosynthesis and modifying enzymes and FAK1 Signaling. GO annotations related to this gene include integrin binding and protein binding. An important paralog of this gene is COL25A1.

UniProtKB/Swiss-Prot: COGA1_HUMAN, Q07092
Function: Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell
spreading and alterations in cell morphology

Gene Wiki entry for COL16A1 (Collagen, type XVI, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COL16A1 gene promoter:
         ISGF-3   GATA-3   MIF-1   IRF-1   Nkx2-5   PPAR-alpha   PPAR-gamma1   POU2F1   HOXA5   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOL16A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for COL16A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL16A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35-p34   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p35-p34

COL16A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL16A1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M032117:  view genomic region     (about GC identifiers)

Start:
32,117,848 bp from pter      End:
32,169,920 bp from pter
Size:
52,073 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COGA1_HUMAN, Q07092 (See protein sequence)
Recommended Name: Collagen alpha-1(XVI) chain precursor  
Size: 1604 amino acids; 157751 Da
Subunit: Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin
ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains
COL1-COL3
Subcellular location: Secreted, extracellular space, extracellular matrix
Developmental stage: Transiently elevated expression during gestation, and decrease at term
Secondary accessions: Q16593 Q59F89 Q71RG9
Alternative splicing: 2 isoforms:  Q07092-1   Q07092-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COL16A1: NX_Q07092

Explore proteomics data for COL16A1 at MOPED 

Post-translational modifications:

  • UniProtKB: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the
    chains
  • UniProtKB: Glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07092

  • COL16A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COL16A1 Protein Expression
    REFSEQ proteins: NP_001847.3  
    ENSEMBL proteins: 
     ENSP00000362776   ENSP00000473991   ENSP00000390281   ENSP00000411457   ENSP00000362772  
     ENSP00000362771   ENSP00000271069  
    Reactome Protein details: Q07092
    Human Recombinant Protein Products for COL16A1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005597collagen type XVI TAS1284248
    GO:0005788endoplasmic reticulum lumen TAS--

    COL16A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    COLLAGEN: Collagens

    3 InterPro protein domains:
     IPR001791 Laminin_G
     IPR008160 Collagen
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q07092

    ProtoNet protein and cluster: Q07092

    3 Blocks protein domains:
    IPB003129 Thrombospondin
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: COGA1_HUMAN, Q07092
    Domain: This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten
    non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule
    either elastic or flexible
    Similarity: Belongs to the fibril-associated collagens with interrupted helices (FACIT) family
    Similarity: Contains 8 collagen-like domains
    Similarity: Contains 1 laminin G-like domain


    COL16A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COGA1_HUMAN, Q07092
    Function: Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell
    spreading and alterations in cell morphology

         Genatlas biochemistry entry for COL16A1:
    collagen,type XVI,alpha 1,with features of fibril associated collagen with interrupted helices (?FACIT variant)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IDA16754661
    GO:0005515protein binding IPI15165854
         
    COL16A1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCOL16A1 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COL16A1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.74
    Extracellular matrix organization0.39
    Collagen formation0.74
    Blood Coagulation Cascade0.39
    Intrinsic Prothrombin Activation Pathway0.40
    2Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.79
    Degradation of collagen0.79
    5PTEN Pathway
    PTEN Pathway0.56
    Phospholipase-C Pathway0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL16A1 (see all 15)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    5        Reactome Pathways for COL16A1
        Extracellular matrix organization
    Collagen biosynthesis and modifying enzymes
    Degradation of the extracellular matrix
    Collagen formation
    Degradation of collagen



    COL16A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COL16A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for COL16A1 (Q070922, 3 ENSP000003627764) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFAPP141362, 3, ENSP000002534084MINT-6743170 I2D: score=1 STRING: ENSP00000253408
    COL4A1P024622, ENSP000003649794MINT-6743179 STRING: ENSP00000364979
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    COL10A1ENSP000002432224STRING: ENSP00000243222
    COL11A1ENSP000003511634STRING: ENSP00000351163
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IDA16754661
    GO:0007229integrin-mediated signaling pathway TAS16754661
    GO:0007565female pregnancy TAS1284248
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--

    COL16A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COL16A1 (COGA1)

    Search CenterWatch for drugs/clinical trials and news about COL16A1 / COGA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COL16A1 gene: 
    NM_001856.3  

    Unigene Cluster for COL16A1:

    Collagen, type XVI, alpha 1
    Hs.368921  [show with all ESTs]
    Unigene Representative Sequence: NM_001856
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000373672(uc001btj.1 uc001btk.1) ENST00000489280 ENST00000488128
    ENST00000488897 ENST00000461217 ENST00000440437 ENST00000466829 ENST00000470799
    ENST00000482910 ENST00000468459 ENST00000479100 ENST00000458715 ENST00000373668(uc001btl.4)
    ENST00000474000 ENST00000482478 ENST00000529928 ENST00000373667 ENST00000532877

    miRNA
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    Additional mRNA sequence: 

    AB209571.1 AF370368.1 BC064839.1 BC118655.1 M92642.1 S57132.1 X14963.1 X15038.1 

    16 DOTS entries:

    DT.444233  DT.99990364  DT.95298015  DT.40231039  DT.75130869  DT.433295  DT.95154274  DT.100645420 
    DT.121442523  DT.75192513  DT.91829406  DT.92425382  DT.100750193  DT.313921  DT.91754176  DT.92425383 

    24/106 AceView cDNA sequences (see all 106):

    BF434543 BM664872 X14963 BC064839 AI686616 BU733264 BU182098 BG697379 
    CA394098 AA770215 CR611324 CB215004 X15038 BF223892 BF058423 AI656575 
    AI589349 AA682251 BM707745 CF455572 BP363100 BQ001266 BF718643 BQ716545 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for COL16A1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
    SP1:                                                                                                  -                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33
    SP1:                                                                              
    SP2:                                      -                                       
    SP3:                                      -                                       
    SP4:                                      -                                       
    SP5:                                                                              


    ECgene alternative splicing isoforms for COL16A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COL16A1 expression in normal human tissues (normalized intensities)      COL16A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGGCCTT
    COL16A1 Expression
    About this image


    COL16A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Chondrocytes Zeugopod Epiphyseal End
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             Chondrocytes Zeugopod Epiphyseal End
             TGFbeta3+BMP7-induced chondrocytes
     
     Kidney (Urinary System)
             Metanephros
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow

    See COL16A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COL16A1

    SOURCE GeneReport for Unigene cluster: Hs.368921

    UniProtKB/Swiss-Prot: COGA1_HUMAN, Q07092
    Tissue specificity: In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils,
    whereas in territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen
    fibrils in association with other collagens (at protein level). In the placenta, where it is found in the amnion,
    a membranous tissue lining the amniotic cavity. Within the amnion, it is found in an acellular, relatively dense
    layer of a complex network of reticular fibers. Also located to a fibroblast layer beneath this dense layer.
    Exists in tissues in association with other types of collagen

        SABiosciences Expression via Pathway-Focused PCR Array including COL16A1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for COL16A1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Col16a11 , 5 collagen, type XVI, alpha 11, 5 86.43(n)1
    89.95(a)1
      4 (63.43 cM)5
    1075811  NM_028266.51  NP_082542.31 
     1300478405 
    chicken
    (Gallus gallus)
    Aves LOC4304771 collagen alpha-1(XVI) chain-like 67.39(n)
    69.16(a)
      430477  XM_003642581.1  XP_003642629.1 
    lizard
    (Anolis carolinensis)
    Reptilia COL16A16
    Uncharacterized protein
    69(a)
    1 ↔ 1
    GL343308.1(445179-593713)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005357821 collagen alpha-1(XIX) chain-like 55.34(n)
    56.02(a)
      100535782  XM_003200625.1  XP_003200673.1 


    ENSEMBL Gene Tree for COL16A1 (if available)
    TreeFam Gene Tree for COL16A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COL16A1 gene
    COL25A12  COL19A12  COL9A12  COL22A12  COL13A12  COL9A32  COL9A22  COL21A12  
    COL23A12  
    6 SIMAP similar genes for COL16A1 using alignment to 6 protein entries:     COGA1_HUMAN (see all proteins):
    SFTPD    COL17A1    COLEC11    FCN2    COL7A1    MARCO

    COL16A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1436 SNPs in COL16A1 are shown (see all 1436)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836995761,2
    --30289259(+) ACACAC/TGTAAG 1 -- us2k10--------
    rs783132331,2
    C--32117373(+) AGGTTC/TCATCT 1 -- ds50010--------
    rs771905551,2
    C--32117374(+) GGTTCC/TATCTC 1 -- ds50010--------
    rs1388079151,2
    --32117388(+) TCCCAA/GAGAAG 1 -- ds50010--------
    rs1140715661,2
    --32117429(+) GCCTGC/TCTTCT 1 -- ds50010--------
    rs743583331,2
    C--32117709(+) CTTGAG/CAGAAG 1 -- ds50012Minor allele frequency- C:0.04NA EA 122
    rs21395391,2
    C,F,O,A,H--32117779(+) GATCCC/TGAGGA 1 -- ds500130Minor allele frequency- T:0.30NA NS EA CSA WA 2918
    rs1818423911,2
    C--32117807(+) GCCCCC/TATCCA 1 -- ds50010--------
    rs1414423621,2
    C--32117822(+) AATCT-/CACAGCA 1 -- ds50010--------
    rs1861871901,2
    --32117826(+) TCACAC/GCACCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for COL16A1 (32117848 - 32169920 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for COL16A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528364CNV Loss19592680
    nsv818123CNV Loss17921354
    dgv209n71CNV Loss21882294
    nsv470708CNV Loss18288195
    nsv461028CNV Loss19166990
    nsv870517CNV Loss21882294
    dgv46e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 120326    OMIM disorders: --

    4 diseases for COL16A1:    About MalaCards
    epidermolysis bullosa    oral cancer    skin disease    glioblastoma


    COL16A1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): COL16A1
    Human Genome Epidemiology (HuGE) Navigator: COL16A1 (3 documents)

    Export disorders for COL16A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COL16A1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with COL16A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal location of human alpha 1(XVI) collagen. (PubMed id 1631157)1, 2, 3 Pan T.-C.... Chu M.-L. (1992)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains. (PubMed id 16754661)1, 2 Eble J.A.... Grassel S. (2006)
    5. Molecular structure and interaction of recombinant human type XVI collagen. (PubMed id 15165854)1, 2 Kassner A.... Grassel S. (2004)
    6. Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils. (PubMed id 12782140)1, 2 Kassner A.... Grassel S. (2003)
    7. Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells. (PubMed id 9022684)1, 2 Grassel S.... Chu M.-L. (1996)
    8. Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain. (PubMed id 7882999)1, 2 Tillet E.... Timpl R. (1995)
    9. Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments. (PubMed id 1284248)1, 2 Yamaguchi N.... Nagai Y. (1992)
    10. Collagen XVI in health and disease. (PubMed id 23149016)1 Grassel S. and Bauer R.J. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1307 HGNC: 2193 AceView: COL16A1 Ensembl:ENSG00000084636 euGenes: HUgn1307
    ECgene: COL16A1 H-InvDB: COL16A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COL16A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COL16A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COL16A1 gene:
    Search GeneIP for patents involving COL16A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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