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Aliases for COL15A1 Gene

Aliases for COL15A1 Gene

  • Collagen, Type XV, Alpha 1 2 3
  • Collagen Type XV Proteoglycan 2 3
  • Collagen XV, Alpha-1 Polypeptide 3
  • Collagen Alpha-1(XV) Chain 3
  • Endostatin-XV 3
  • Restin 3

External Ids for COL15A1 Gene

Summaries for COL15A1 Gene

Entrez Gene Summary for COL15A1 Gene

  • This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]

GeneCards Summary for COL15A1 Gene

COL15A1 (Collagen, Type XV, Alpha 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is COL18A1.

UniProtKB/Swiss-Prot for COL15A1 Gene

  • Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.

  • Restin potently inhibits angiogenesis.

Gene Wiki entry for COL15A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COL15A1 Gene

Genomics for COL15A1 Gene

Genomic Location for COL15A1 Gene

Start:
98,943,179 bp from pter
End:
99,070,792 bp from pter
Size:
127,614 bases
Orientation:
Plus strand

Genomic View for COL15A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COL15A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COL15A1 Gene

Regulatory Elements for COL15A1 Gene

Proteins for COL15A1 Gene

  • Protein details for COL15A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39059-COFA1_HUMAN
    Recommended name:
    Collagen alpha-1(XV) chain
    Protein Accession:
    P39059
    Secondary Accessions:
    • Q5T6J4
    • Q9UDC5
    • Q9Y4W4

    Protein attributes for COL15A1 Gene

    Size:
    1388 amino acids
    Molecular mass:
    141720 Da
    Quaternary structure:
    • Trimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for COL15A1 Gene

neXtProt entry for COL15A1 Gene

Proteomics data for COL15A1 Gene at MOPED

Post-translational modifications for COL15A1 Gene

  • O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate.
  • Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr265, Asn306, Asn324, Asn687, Asn807, Asn814, and Asn1046

Other Protein References for COL15A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COL15A1 Gene

Domains for COL15A1 Gene

Gene Families for COL15A1 Gene

HGNC:
  • COLLAGEN :Collagens
  • COLPG :Proteoglycans / Extracellular Matrix : Collagen proteoglycans

UniProtKB/Swiss-Prot:

COFA1_HUMAN
Domain:
  • Contains 4 collagen-like domains.:
    • P39059
  • Contains 1 laminin G-like domain.:
    • P39059
Family:
  • Belongs to the multiplexin collagen family.:
    • P39059
genes like me logo Genes that share domains with COL15A1: view

Function for COL15A1 Gene

Molecular function for COL15A1 Gene

GENATLAS Biochemistry: collagen,type XV,alpha 1,multiplexin family with interrupted helical domain
UniProtKB/Swiss-Prot Function: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.
UniProtKB/Swiss-Prot Function: Restin potently inhibits angiogenesis.

Gene Ontology (GO) - Molecular Function for COL15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0005201 extracellular matrix structural constituent IC 9651385
genes like me logo Genes that share ontologies with COL15A1: view

Phenotypes for COL15A1 Gene

genes like me logo Genes that share phenotypes with COL15A1: view

Animal Models for COL15A1 Gene

MGI Knock Outs for COL15A1:

miRNA for COL15A1 Gene

miRTarBase miRNAs that target COL15A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for COL15A1 Gene

Localization for COL15A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COL15A1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COL15A1 Gene COMPARTMENTS Subcellular localization image for COL15A1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
mitochondrion 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for COL15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005582 collagen type XV trimer TAS 9651385
GO:0005604 basement membrane --
GO:0005615 extracellular space IDA 20551380
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with COL15A1: view

Pathways for COL15A1 Gene

genes like me logo Genes that share pathways with COL15A1: view

Interacting Proteins for COL15A1 Gene

Gene Ontology (GO) - Biological Process for COL15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007155 cell adhesion IC 9651385
GO:0007165 signal transduction NAS 10891348
GO:0022617 extracellular matrix disassembly TAS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with COL15A1: view

Transcripts for COL15A1 Gene

Unigene Clusters for COL15A1 Gene

Collagen, type XV, alpha 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COL15A1 Gene

No ASD Table

Relevant External Links for COL15A1 Gene

GeneLoc Exon Structure for
COL15A1
ECgene alternative splicing isoforms for
COL15A1

Expression for COL15A1 Gene

mRNA expression in normal human tissues for COL15A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COL15A1 Gene

SOURCE GeneReport for Unigene cluster for COL15A1 Gene Hs.409034

mRNA Expression by UniProt/SwissProt for COL15A1 Gene

P39059-COFA1_HUMAN
Tissue specificity: Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney
genes like me logo Genes that share expressions with COL15A1: view

Orthologs for COL15A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for COL15A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COL15A1 36
  • 99.23 (n)
  • 98.8 (a)
COL15A1 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COL15A1 36
  • 84.36 (n)
  • 81.44 (a)
COL15A1 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COL15A1 36
  • 84.09 (n)
  • 82.14 (a)
COL15A1 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Col15a1 36
  • 78.09 (n)
  • 76.95 (a)
Col15a1 16
Col15a1 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COL15A1 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COL15A1 37
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves COL15A1 37
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COL15A1 37
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii COL15A1 (2 of 2) 37
  • 54 (a)
OneToMany
col15a1b 36
  • 56.54 (n)
  • 53.2 (a)
col15a1b 37
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mp 36
  • 47.67 (n)
  • 39.15 (a)
mp 37
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cle-1 37
  • 18 (a)
OneToMany
cle-1 38
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
Species with no ortholog for COL15A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for COL15A1 Gene

ENSEMBL:
Gene Tree for COL15A1 (if available)
TreeFam:
Gene Tree for COL15A1 (if available)

Paralogs for COL15A1 Gene

Paralogs for COL15A1 Gene

genes like me logo Genes that share paralogs with COL15A1: view

Variants for COL15A1 Gene

Sequence variations from dbSNP and Humsavar for COL15A1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs10519 - 99,069,713(+) ATGGC(A/G)TCCGC missense, reference
rs869775 -- 99,048,401(-) AAGTA(C/G)CTGAT intron-variant
rs869776 -- 99,048,057(-) ACCCC(A/G)CACTC intron-variant
rs874165 -- 99,015,319(-) CAGAT(A/T)ACTGG intron-variant
rs882221 -- 98,968,805(-) GCCCC(C/T)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COL15A1 Gene

Variant ID Type Subtype PubMed ID
esv2738827 CNV Deletion 23290073
nsv6635 CNV Loss 18451855
esv270049 CNV Insertion 20981092
nsv528933 CNV Loss 19592680
nsv466442 CNV Loss 19166990
nsv893618 CNV Gain 21882294

Relevant External Links for COL15A1 Gene

HapMap Linkage Disequilibrium report
COL15A1
Human Gene Mutation Database (HGMD)
COL15A1

Disorders for COL15A1 Gene

Relevant External Links for COL15A1

Genetic Association Database (GAD)
COL15A1
Human Genome Epidemiology (HuGE) Navigator
COL15A1
genes like me logo Genes that share disorders with COL15A1: view

No data available for UniProtKB/Swiss-Prot for COL15A1 Gene

Publications for COL15A1 Gene

  1. Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22. (PMID: 1427836) Huebner K. … Myers J.C. (Genomics 1992) 2 3 4
  2. Primary structure of the alpha 1 chain of human type XV collagen and exon-intron organization in the 3' region of the corresponding gene. (PMID: 8106446) Kivirikko S. … Pihlajaniemi T. (J. Biol. Chem. 1994) 3 4
  3. The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen. (PMID: 8307960) Muragaki Y. … Ooshima A. (J. Biol. Chem. 1994) 3 4
  4. Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene. (PMID: 9651385) Haegg P.M. … Pihlajaniemi T. (J. Biol. Chem. 1998) 3 4
  5. Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. (PMID: 10049780) Ramchandran R. … Sukhatme V.P. (Biochem. Biophys. Res. Commun. 1999) 3 4

Products for COL15A1 Gene

  • antibodies-online peptides for COL15A1
  • antibodies-online antibodies for COL15A1
  • antibodies-online kits for COL15A1

Sources for COL15A1 Gene

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