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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COL15A1 Gene

protein-coding GIFtS: 53
GCID: GC09P101705

collagen, type XV, alpha 1

Explore 1 disease affiliated with
COL15A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Collagen, Type XV, Alpha 1¹ ²
Collagen Alpha-1(XV) Chain²
Collagen Type XV Proteoglycan²
Collagen XV, Alpha-1 Polypeptide²

External Ids:	HGNC: 2192¹	Entrez Gene: 1306²	Ensembl: ENSG00000204291⁷	OMIM: 120325⁵	UniProtKB: P39059³

Export aliases for COL15A1 gene to outside databases

Previous GC identifers: GC09P092506 GC09P093449 GC09P095163 GC09P097086 GC09P098785 GC09P100746 GC09P071304

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COL15A1:

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated

collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is

localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue

stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059

Function: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle

Function: Endostatin potently inhibits angiogenesis (By similarity)

Gene Wiki entry for COL15A1 (Collagen, type XV, alpha 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COL15A1 gene promoter:
COUP-TF1 LHX3b/Lhx3b Brachyury COUP HNF-4alpha2 CUTL1 HNF-4alpha1 c-Ets-1 COUP-TF LHX3a/Lhx3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COL15A1 promoter sequence

Search SABiosciences Chromatin IP Primers for COL15A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL15A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21-q22 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q21-q22

COL15A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL15A1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P101705: view genomic region (about GC identifiers)

Start:	101,705,461 bp from pter	End:	101,833,069 bp from pter
Size:	127,609 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059 (See protein sequence)

Recommended Name: Collagen alpha-1(XV) chain precursor

Size: 1388 amino acids; 141720 Da

Subunit: Trimer; disulfide-linked

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

1 PDB 3D structure from and Proteopedia for COL15A1:

3N3F (3D)

Secondary accessions: Q5T6J4 Q9UDC5 Q9Y4W4

Explore the universe of human proteins at neXtProt for COL15A1: NX_P39059

Post-translational modifications:

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains¹

O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P39059

COL15A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001846.3

ENSEMBL proteins:

ENSP00000364140

Reactome Protein details: P39059
Human Recombinant Protein Products for COL15A1:

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	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005582	collagen type XV	TAS	9651385
GO:0005604	basement membrane	IEA	--
GO:0005615	extracellular space	IDA	--
GO:0005788	endoplasmic reticulum lumen	TAS	--

COL15A1 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COL15A1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001791 Laminin_G

IPR016187 C-type_lectin_fold

IPR010515 Collagenase_NC10/endostatin

IPR016186 C-type_lectin-like

IPR008160 Collagen

Graphical View of Domain Structure for InterPro Entry P39059

ProtoNet protein and cluster: P39059

5 Blocks protein families:

IPB001791 Laminin G

IPB003129 Thrombospondin

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

IPB010515 Collagenase NC10 and endostatin

UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059

Similarity: Belongs to the multiplexin collagen family

Similarity: Contains 4 collagen-like domains

Similarity: Contains 1 laminin G-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: COFA1_HUMAN, P39059

Function: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle

Function: Endostatin potently inhibits angiogenesis (By similarity)

Genatlas biochemistry entry for COL15A1:

collagen,type XV,alpha 1,multiplexin family with interrupted helical domain

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	IC	9651385

COL15A1 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Col15a1):

cardiovascular system

muscle

COL15A1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Col15a1^tm1Pih for COL15A1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for COL15A1

miRNA Products:		miRTarBase miRNAs that target COL15A1: hsa-mir-29c (MIRT001925)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL15A1
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate COL15A1 (see all 25):
		hsa-miR-4307 hsa-miR-4328 hsa-let-7d hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-let-7c hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: COL15A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL15A1 (see all 4) OriGene shRNA RFP: COL15A1 OriGene siRNA: COL15A1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against COL15A1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for COL15A1
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		GenScript: all cDNA clones in your preferred vector: COL15A1 (NM_001855)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL15A1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL15A1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Collagen formation

Collagen formation	1.00	Extracellular matrix organization	0.54
Collagen biosynthesis and modifying enzymes	0.74	Secretion of collagens	0.49
Assembly of collagen fibrils and other multimeric structures	0.65

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Degradation of the extracellular matrix

Degradation of the extracellular matrix

1.00

Degradation of collagen

0.79

Blood Coagulation Cascade

Blood Coagulation Cascade

1.00

Intrinsic Prothrombin Activation Pathway

0.96

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL15A1 (see all 15)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

5/8 Reactome Pathways for COL15A1 (see all 8)

	Collagen type XV restin release
	Extracellular matrix organization
	Secretion of collagens
	Collagen biosynthesis and modifying enzymes
	Assembly of collagen fibrils and other multimeric structures

1 Kegg Pathway (Kegg details for COL15A1):

Protein digestion and absorption

COL15A1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for COL15A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/41 Interacting proteins for COL15A1 (ENSP00000364140⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COL10A1	ENSP00000243222⁴	STRING: ENSP00000243222
COL11A1	ENSP00000351163⁴	STRING: ENSP00000351163
COL12A1	ENSP00000325146⁴	STRING: ENSP00000325146
COL13A1	ENSP00000348695⁴	STRING: ENSP00000348695
COL14A1	ENSP00000297848⁴	STRING: ENSP00000297848

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0007155	cell adhesion	IC	9651385
GO:0007165	signal transduction	NAS	10891348
GO:0030154	cell differentiation	IEA	--
GO:0030198	extracellular matrix organization	TAS	--

COL15A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COL15A1
Search CenterWatch for drugs/clinical trials and news about COL15A1 / COFA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COL15A1 gene:

NM_001855.3

Unigene Cluster for COL15A1:

Collagen, type XV, alpha 1

Hs.409034 [show with all ESTs]

Unigene Representative Sequence: NM_001855

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000467052 ENST00000375001(uc004azb.1) ENST00000471477 ENST00000496686

miRNA Products:		OriGene 3'-UTR Clone: COL15A1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL15A1
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate COL15A1 (see all 25):
		hsa-miR-4307 hsa-miR-4328 hsa-let-7d hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-let-7c hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: COL15A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL15A1 (see all 4) OriGene shRNA RFP: COL15A1 OriGene siRNA: COL15A1
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		GenScript: all cDNA clones in your preferred vector: COL15A1 (NM_001855)
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Additional cDNA sequence:

AK095885.1 AK308438.1 D21230.1 L01697.1 L25286.1

7 DOTS entries:

DT.444345 DT.100811433 DT.417602 DT.95259956 DT.95369686 DT.95369687 DT.97799640

24/188 AceView cDNA sequences (see all 188):

CB961016 BM698755 BX378069 CB988709 Z33530 CB046966 BF971380 AL542615

AA777686 C04772 BX489036 CB044840 AA371021 BG741496 BM273036 CA418422

BU146609 AA386188 AW474951 CB044841 T93884 AI873547 AK095885 L01697

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COL15A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

COL15A1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Heart

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Adipose

Visceral White Adipose

Adipose

Brain

Kidney

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See COL15A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COL15A1

SOURCE GeneReport for Unigene cluster: Hs.409034

UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059

Tissue specificity: Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including COL15A1:

Osteogenesis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Cardiotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COL15A1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL15A1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL15A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for COL15A1 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	COL15A1¹	collagen, type XV, alpha 1	66.2(n) 65.83(a)		420803 XM_418896.3 XP_418896.3
lizard (Anolis carolinensis)	Reptilia	COL15A1⁶	--	54(a)	1 ↔ 1	6(55868862-55953501)
zebrafish (Danio rerio)	Actinopterygii	cmn⁶ col15a1b⁶ (see all 3)	collagen, type XV, alpha 1b (see all 3)	6(a) 47(a) (see all 3)	possible ortholog 1 ↔ 1 (see all 3)	12(14224584-14270293) 2(23850967-23927192)
fruit fly (Drosophila melanogaster)	Insecta	pygo⁶ mp⁶	multiplexin	7(a) 32(a)	possible ortholog 1 ↔ 1	3R(27401557-27406412) 3L(6991943-7046528)
worm (Caenorhabditis elegans)	Secernentea	cle-1³	cle-1 isoform A	33(a)		I(8714046-8732339) --

ENSEMBL Gene Tree for COL15A1 (if available)
TreeFam Gene Tree for COL15A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for COL15A1 gene

COL18A1²

COL15A1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143187641^1,2		--	101704201(+)	`TCCCTA/GTGGTT`	1	--	us2k¹		0	--	--	--	--
rs148262859^1,2		--	101704338(+)	`AGTTCA/GCCTTA`	1	--	us2k¹		0	--	--	--	--
rs74525984^1,2	F	--	101704364(+)	`TGAGGC/ACAACC`	1	--	us2k¹		1		NA	120
rs78504118^1,2	F	--	101704524(+)	`TGGACA/GGAGAG`	1	--	us2k¹		1		WA	118
rs181337581^1,2		--	101704657(+)	`ACTTCA/GCCCTG`	1	--	us2k¹		0	--	--	--	--
rs186937824^1,2		--	101704668(+)	`CAGCCA/GGGGCC`	1	--	us2k¹		0	--	--	--	--
rs3824515^1,2	C,F,H	--	101704737(-)	`TGGGCG/AGTGAG`	1	--	us2k¹		19		NS EA NA WA	2340
rs191750403^1,2		--	101704873(+)	`TGGGTC/GTTGCA`	1	--	us2k¹		0	--	--	--	--
rs141268452^1,2		--	101704876(+)	`GTGTTG/TCATCT`	1	--	us2k¹		0	--	--	--	--
rs146235723^1,2		--	101705064(+)	`CATTCC/TCATGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for COL15A1 (101705461 - 101833069 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COL15A1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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COL15A1 for disorders           About GeneDecksing

OMIM gene information: 120325    OMIM disorders: --

1 disease for COL15A1:    About MalaCards

dupuytren contracture

Human Genome Epidemiology (HuGE) Navigator: COL15A1 (3 documents)

Export disorders for COL15A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for COL15A1 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with COL15A1)

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Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22. (PubMed id 1427836)^{1, 2, 3} Huebner K.... Myers J.C. (1992)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells. (PubMed id 10791950)^{1, 2} Li D.... Myers J.C. (2000)
Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. (PubMed id 10049780)^{1, 2} Ramchandran R.... Sukhatme V.P. (1999)
Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene. (PubMed id 9651385)^{1, 2} Haegg P.M.... Pihlajaniemi T. (1998)
Primary structure of the alpha 1 chain of human type XV collagen and exon-intron organization in the 3' region of the corresponding gene. (PubMed id 8106446)^{1, 2} Kivirikko S....Pihlajaniemi T. (1994)
The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen. (PubMed id 8307960)^{1, 2} Muragaki Y.... Ooshima A. (1994)
Identification of a previously unknown human collagen chain, alpha 1(XV), characterized by extensive interruptions in the triple-helical region. (PubMed id 1279671)^{1, 2} Myers J.C.... Pihlajaniemi T. (1992)
Extracellular calcium chronically induced human osteob lasts effects: specific modulation of osteocalcin and collagen type XV. (PubMed id 22034088)¹ Gabusi E....Lisignoli G. (2012)
Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)² Halim A.... Larson G. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1306	HGNC: 2192	AceView: COL15A1	Ensembl:ENSG00000204291	euGenes: HUgn1306
ECgene: COL15A1	Kegg: 1306	H-InvDB: COL15A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for COL15A1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COL15A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for COL15A1 gene:
Search GeneIP for patents involving COL15A1

GeneCards and IP:
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COL15A1 Gene

collagen, type XV, alpha 1

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COL15A1 Gene

collagen, type XV, alpha 1

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