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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COL15A1 Gene

protein-coding   GIFtS: 55
GCID: GC09P101705

Collagen, Type XV, Alpha 1

  Search for COL15A1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Collagen, Type XV, Alpha 11 2
Collagen Type XV Proteoglycan1 2
Collagen Alpha-1(XV) Chain2
Collagen XV, Alpha-1 Polypeptide2
endostatin-XV2
restin2

External Ids:    HGNC: 21921   Entrez Gene: 13062   Ensembl: ENSG000002042917   OMIM: 1203255   UniProtKB: P390593   

Export aliases for COL15A1 gene to outside databases

Previous GC identifers: GC09P092506 GC09P093449 GC09P095163 GC09P097086 GC09P098785 GC09P100746 GC09P071304


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COL15A1 Gene:
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated
collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression
is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective
tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially
antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV
deficiency is associated with muscle and microvessel deterioration. (provided by RefSeq, May 2013)

GeneCards Summary for COL15A1 Gene: 
COL15A1 (collagen, type XV, alpha 1) is a protein-coding gene. Among its related super-pathways are Collagen biosynthesis and modifying enzymes and FAK1 Signaling. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is COL18A1.

UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059
Function: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle
Function: Restin potently inhibits angiogenesis (By similarity)

Gene Wiki entry for COL15A1 (Collagen, type XV, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COL15A1 gene promoter:
         COUP-TF1   LHX3b/Lhx3b   Brachyury   COUP   HNF-4alpha2   CUTL1   HNF-4alpha1   c-Ets-1   COUP-TF   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOL15A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for COL15A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL15A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21-q22   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q21-q22

COL15A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL15A1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P101705:  view genomic region     (about GC identifiers)

Start:
101,705,461 bp from pter      End:
101,833,069 bp from pter
Size:
127,609 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059 (See protein sequence)
Recommended Name: Collagen alpha-1(XV) chain precursor  
Size: 1388 amino acids; 141720 Da
Subunit: Trimer; disulfide-linked
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Caution: The name restin has also been used for CAP-Gly domain-containing linker protein 1 the product of the
CLIP1 gene
1 PDB 3D structure from and Proteopedia for COL15A1:
3N3F (3D)    
Secondary accessions: Q5T6J4 Q9UDC5 Q9Y4W4

Explore the universe of human proteins at neXtProt for COL15A1: NX_P39059

Explore proteomics data for COL15A1 at MOPED 

Post-translational modifications:

  • UniProtKB: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the
    chains
  • UniProtKB: O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P39059

  • COL15A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COL15A1 Protein Expression
    REFSEQ proteins: NP_001846.3  
    ENSEMBL proteins: 
     ENSP00000364140  
    Reactome Protein details: P39059
    Human Recombinant Protein Products for COL15A1: 
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    Browse Sino Biological Cell Lysates 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005582collagen type XV TAS9651385
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA--
    GO:0005788endoplasmic reticulum lumen TAS--

    COL15A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    COLPG: Proteoglycans / Extracellular Matrix : Collagen proteoglycans
    COLLAGEN: Collagens

    5/6 InterPro protein domains (see all 6):
     IPR001791 Laminin_G
     IPR016187 C-type_lectin_fold
     IPR010515 Collagenase_NC10/endostatin
     IPR016186 C-type_lectin-like
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry P39059

    ProtoNet protein and cluster: P39059

    5 Blocks protein domains:
    IPB001791 Laminin G
    IPB003129 Thrombospondin
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat
    IPB010515 Collagenase NC10 and endostatin


    UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059
    Similarity: Belongs to the multiplexin collagen family
    Similarity: Contains 4 collagen-like domains
    Similarity: Contains 1 laminin G-like domain


    COL15A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COFA1_HUMAN, P39059
    Function: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle
    Function: Restin potently inhibits angiogenesis (By similarity)

         Genatlas biochemistry entry for COL15A1:
    collagen,type XV,alpha 1,multiplexin family with interrupted helical domain

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ----
    GO:0005201extracellular matrix structural constituent IC9651385
         
    COL15A1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Col15a1):
     cardiovascular system  muscle 

    COL15A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Col15a1tm1Pih for COL15A1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for COL15A1 
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COL15A1 

    miRNA
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    miRTarBase miRNAs that target COL15A1:
    hsa-mir-29c (MIRT001925)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL15A1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate COL15A1 (see all 25):
    hsa-miR-4307 hsa-miR-4328 hsa-let-7d hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-let-7c hsa-miR-570
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    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL15A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COL15A1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.74
    Intrinsic Prothrombin Activation Pathway0.40
    Collagen formation0.74
    Extracellular matrix organization0.39
    Assembly of collagen fibrils and other multimeric structures0.65
    Blood Coagulation Cascade0.39
    2Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.79
    Degradation of collagen0.79
    5PTEN Pathway
    PTEN Pathway0.56
    Phospholipase-C Pathway0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL15A1 (see all 15)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    5/6        Reactome Pathways for COL15A1 (see all 6)
        Extracellular matrix organization
    Collagen biosynthesis and modifying enzymes
    Assembly of collagen fibrils and other multimeric structures
    Degradation of the extracellular matrix
    Collagen formation


    1         Kegg Pathway  (Kegg details for COL15A1):
        Protein digestion and absorption


    COL15A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COL15A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for COL15A1 (ENSP000003641404) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL10A1ENSP000002432224STRING: ENSP00000243222
    COL11A1ENSP000003511634STRING: ENSP00000351163
    COL12A1ENSP000003251464STRING: ENSP00000325146
    COL13A1ENSP000003486954STRING: ENSP00000348695
    COL14A1ENSP000002978484STRING: ENSP00000297848
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0007155cell adhesion IC9651385
    GO:0007165signal transduction NAS10891348
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030154cell differentiation IEA--

    COL15A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COL15A1 (COFA1)

    Search CenterWatch for drugs/clinical trials and news about COL15A1 / COFA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COL15A1 gene: 
    NM_001855.4  

    Unigene Cluster for COL15A1:

    Collagen, type XV, alpha 1
    Hs.409034  [show with all ESTs]
    Unigene Representative Sequence: NM_001855
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467052 ENST00000471477 ENST00000375001(uc004azb.1) ENST00000496686

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    Additional mRNA sequence: 

    AK095885.1 AK308438.1 D21230.1 L01697.1 L25286.1 

    7 DOTS entries:

    DT.444345  DT.100811433  DT.417602  DT.95259956  DT.95369686  DT.95369687  DT.97799640 

    24/188 AceView cDNA sequences (see all 188):

    AL542615 CB988709 BG741496 BM273036 CA418422 BU146609 AI341086 CR595376 
    CD613058 CA432207 AV708101 BM273267 BQ575841 BM142008 AA386188 CR602416 
    CB044841 AK095885 T93884 AW474951 L01697 AI873547 BM141734 BQ004411 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COL15A1 expression in normal human tissues (normalized intensities)      COL15A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    COL15A1 Expression
    About this image


    COL15A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
             Normal Human Articular chondrocytes (NHAC)   
     
     Fibroblast
             X-gene Foreskin Fibroblasts   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Atrioventricular Node Cells Atrioventricular Node
             Coronary Artery Smooth Muscle Cells (CASMC)   
             heart/pericardium   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             Immature Schwann Cells Peripheral Nerve Domain
             Human Perineurial Cells (HPC)   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
             mesenchyme   

    See COL15A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COL15A1

    SOURCE GeneReport for Unigene cluster: Hs.409034

    UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059
    Tissue specificity: Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including COL15A1: 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cardiotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL15A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for COL15A1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Col15a11 , 5 collagen, type XV, alpha 11, 5 78.79(n)1
    77.86(a)1
      4 (26.01 cM)5
    128191  NM_009928.31  NP_034058.21 
     472081615 
    chicken
    (Gallus gallus)
    Aves COL15A11 collagen, type XV, alpha 1 66.2(n)
    65.83(a)
      420803  XM_418896.3  XP_418896.3 
    lizard
    (Anolis carolinensis)
    Reptilia COL15A16
    collagen, type XV, alpha 1
    55(a)
    1 ↔ 1
    6(55866411-56023235)
    zebrafish
    (Danio rerio)
    Actinopterygii col15a1b6
    collagen, type XV, alpha 1b
    43(a)
    1 ↔ 1
    2(23850967-23927192)
    fruit fly
    (Drosophila melanogaster)
    Insecta mp6
    multiplexin
    30(a)
    1 ↔ 1
    3L(6991943-7046528)


    ENSEMBL Gene Tree for COL15A1 (if available)
    TreeFam Gene Tree for COL15A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COL15A1 gene
    COL18A12  

    COL15A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2941 SNPs in COL15A1 are shown (see all 2941)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715018841,2
    C,F--101704066(+) AGATCT/CACTAT 1 -- us2k16Minor allele frequency- C:0.28NA WA EA 364
    rs1431876411,2
    --101704201(+) TCCCTA/GTGGTT 1 -- us2k10--------
    rs1482628591,2
    --101704338(+) AGTTCA/GCCTTA 1 -- us2k10--------
    rs745259841,2
    C,F--101704364(+) TGAGGC/ACAACC 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs785041181,2
    C,F--101704524(+) TGGACA/GGAGAG 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1813375811,2
    C--101704657(+) ACTTCA/GCCCTG 1 -- us2k10--------
    rs1869378241,2
    --101704668(+) CAGCCA/GGGGCC 1 -- us2k10--------
    rs38245151,2
    C,F,H--101704737(-) TGGGCG/AGTGAG 1 -- us2k119Minor allele frequency- A:0.26NS EA NA WA 2340
    rs1917504031,2
    --101704873(+) TGGGTC/GTTGCA 1 -- us2k10--------
    rs1412684521,2
    --101704876(+) GTGTTG/TCATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COL15A1 (101705461 - 101833069 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for COL15A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738827CNV Deletion23290073
    esv270049CNV Insertion20981092
    nsv466442CNV Loss19166990
    nsv528933CNV Loss19592680
    nsv6635CNV Loss18451855
    nsv893618CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    COL15A1 for disorders           About MalaCards
    OMIM gene information: 120325    OMIM disorders: --


    COL15A1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): COL15A1
    Human Genome Epidemiology (HuGE) Navigator: COL15A1 (3 documents)

    Export disorders for COL15A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COL15A1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with COL15A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22. (PubMed id 1427836)1, 2, 3 Huebner K.... Myers J.C. (1992)
    2. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    3. Polymorphisms in COL15 gene are not associated with systemic sclerosis. (PubMed id 18203317)1, 4 Pushpakom S.P....Worthington J. (2008)
    4. Identification and characterization of novel endogenous proteolytic forms of the human angiogenesis inhibitors restin and endostatin. (PubMed id 15698950)1, 2 John H.... Forssmann W.G. (2005)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells. (PubMed id 10791950)1, 2 Li D.... Myers J.C. (2000)
    7. Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. (PubMed id 10049780)1, 2 Ramchandran R.... Sukhatme V.P. (1999)
    8. Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene. (PubMed id 9651385)1, 2 Haegg P.M.... Pihlajaniemi T. (1998)
    9. Primary structure of the alpha 1 chain of human type XV collagen and exon-intron organization in the 3' region of the corresponding gene. (PubMed id 8106446)1, 2 Kivirikko S....Pihlajaniemi T. (1994)
    10. The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen. (PubMed id 8307960)1, 2 Muragaki Y.... Ooshima A. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1306 HGNC: 2192 AceView: COL15A1 Ensembl:ENSG00000204291 euGenes: HUgn1306
    ECgene: COL15A1 Kegg: 1306 H-InvDB: COL15A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COL15A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COL15A1 gene:
    Search GeneIP for patents involving COL15A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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