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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COL15A1 Gene

protein-coding   GIFtS: 53
GCID: GC09P101705

collagen, type XV, alpha 1
 Explore 1 disease affiliated with
COL15A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for COL15A1    

Aliases
for COL15A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Collagen, Type XV, Alpha 11 2
Collagen Alpha-1(XV) Chain2
Collagen Type XV Proteoglycan2
Collagen XV, Alpha-1 Polypeptide2

External Ids:    HGNC: 21921   Entrez Gene: 13062   Ensembl: ENSG000002042917   OMIM: 1203255   UniProtKB: P390593   

Export aliases for COL15A1 gene to outside databases

Previous GC identifers: GC09P092506 GC09P093449 GC09P095163 GC09P097086 GC09P098785 GC09P100746 GC09P071304


Summaries
for COL15A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for COL15A1:
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated
collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is
localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue
stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059
Function: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle
Function: Endostatin potently inhibits angiogenesis (By similarity)

Gene Wiki entry for COL15A1 (Collagen, type XV, alpha 1)


Genomic Views
for COL15A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COL15A1 gene promoter:
         COUP-TF1   LHX3b/Lhx3b   Brachyury   COUP   HNF-4alpha2   CUTL1   HNF-4alpha1   c-Ets-1   COUP-TF   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COL15A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for COL15A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL15A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21-q22   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q21-q22

COL15A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL15A1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P101705:  view genomic region     (about GC identifiers)

Start:
 101,705,461 bp from pter      End:
 101,833,069 bp from pter
Size:
 127,609 bases      Orientation:
 plus strand

Proteins
for COL15A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059 (See protein sequence)
Recommended Name: Collagen alpha-1(XV) chain precursor  
Size: 1388 amino acids; 141720 Da
Subunit: Trimer; disulfide-linked
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
1 PDB 3D structure from and Proteopedia for COL15A1:
3N3F (3D)    
Secondary accessions: Q5T6J4 Q9UDC5 Q9Y4W4

Explore the universe of human proteins at neXtProt for COL15A1: NX_P39059

Post-translational modifications:

  • Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains1
  • O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P39059

    • COL15A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001846.3  
    ENSEMBL proteins: 
     ENSP00000364140  
    Reactome Protein details: P39059
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: COL15A1
    OriGene Protein Over-expression Lysate: COL15A1
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    Novus Biologicals COL15A1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005582collagen type XV TAS9651385
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA--
    GO:0005788endoplasmic reticulum lumen TAS--


    COL15A1 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for COL15A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    COL15A1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001791 Laminin_G
     IPR016187 C-type_lectin_fold
     IPR010515 Collagenase_NC10/endostatin
     IPR016186 C-type_lectin-like
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry P39059

    ProtoNet protein and cluster: P39059

    5 Blocks protein families:
    IPB001791 Laminin G
    IPB003129 Thrombospondin
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat
    IPB010515 Collagenase NC10 and endostatin


    UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059
    Similarity: Belongs to the multiplexin collagen family
    Similarity: Contains 4 collagen-like domains
    Similarity: Contains 1 laminin G-like domain


    Function
    for COL15A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059
    Function: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle
    Function: Endostatin potently inhibits angiogenesis (By similarity)

         Genatlas biochemistry entry for COL15A1:
    collagen,type XV,alpha 1,multiplexin family with interrupted helical domain

    miRNA
    Products:            		miRTarBase miRNAs that target COL15A1:
    hsa-mir-29c (MIRT001925)

    OriGene 3'-UTR Clone: COL15A1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL15A1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate COL15A1 (see all 25):
    hsa-miR-4307 hsa-miR-4328 hsa-let-7d hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-let-7c hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: COL15A1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL15A1 (see all 4)
    OriGene shRNA RFP: COL15A1
    OriGene siRNA: COL15A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL15A1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for COL15A1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COL15A1 (see all 2)
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    GenScript: all cDNA clones in your preferred vector: COL15A1 (NM_001855)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL15A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL15A1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for COL15A1
    LifeMap BioReagents: cell lines associated with COL15A1: PureStem SK11, NCr-fac & Meso-prx Progenitor,
    PureStem SM30, NCr-fac & Meso-latp Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL15A1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent IC9651385


    COL15A1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Col15a1tm1Pih for COL15A1
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Col15a1):
     cardiovascular system  muscle 

    COL15A1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for COL15A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    		Integrin Pathway1.00
    		UPA-UPAR Pathway0.51
    		FAK1 Signaling0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56
    		Inhibition of Angiogenesis by TSP10.37
    2Collagen formation
    		Collagen formation1.00
    		Extracellular matrix organization0.54
    		Collagen biosynthesis and modifying enzymes0.74
    		Secretion of collagens0.49
    		Assembly of collagen fibrils and other multimeric structures0.65
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4Degradation of the extracellular matrix
    		Degradation of the extracellular matrix1.00
    		Degradation of collagen0.79
    5Blood Coagulation Cascade
    		Blood Coagulation Cascade1.00
    		Intrinsic Prothrombin Activation Pathway0.96

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL15A1 (see all 15)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    5/8        Reactome Pathways for COL15A1 (see all 8)
        Collagen type XV restin release
    Extracellular matrix organization
    Secretion of collagens
    Collagen biosynthesis and modifying enzymes
    Assembly of collagen fibrils and other multimeric structures


    1         Kegg Pathway  (Kegg details for COL15A1):
        Protein digestion and absorption


    COL15A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COL15A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for COL15A1 (ENSP000003641404) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL10A1ENSP000002432224STRING: ENSP00000243222
    COL11A1ENSP000003511634STRING: ENSP00000351163
    COL12A1ENSP000003251464STRING: ENSP00000325146
    COL13A1ENSP000003486954STRING: ENSP00000348695
    COL14A1ENSP000002978484STRING: ENSP00000297848
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0007155cell adhesion IC9651385
    GO:0007165signal transduction NAS10891348
    GO:0030154cell differentiation IEA--
    GO:0030198extracellular matrix organization TAS--


    COL15A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for COL15A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COL15A1
    Search CenterWatch for drugs/clinical trials and news about COL15A1 / COFA1 

    Transcripts
    for COL15A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for COL15A1 gene: 
    NM_001855.3  

    Unigene Cluster for COL15A1:

    Collagen, type XV, alpha 1
    Hs.409034  [show with all ESTs]
    Unigene Representative Sequence: NM_001855
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467052 ENST00000375001(uc004azb.1) ENST00000471477 ENST00000496686


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL15A1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate COL15A1 (see all 25):
    hsa-miR-4307 hsa-miR-4328 hsa-let-7d hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-let-7c hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: COL15A1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL15A1 (see all 4)
    OriGene shRNA RFP: COL15A1
    OriGene siRNA: COL15A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL15A1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COL15A1 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COL15A1
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    GenScript: all cDNA clones in your preferred vector: COL15A1 (NM_001855)
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    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COL15A1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL15A1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL15A1

    Additional cDNA sequence: 

    AK095885.1 AK308438.1 D21230.1 L01697.1 L25286.1 

    7 DOTS entries:

    DT.444345  DT.100811433  DT.417602  DT.95259956  DT.95369686  DT.95369687  DT.97799640 

    24/188 AceView cDNA sequences (see all 188):

    CB961016 BM698755 BX378069 CB988709 Z33530 CB046966 BF971380 AL542615 
    AA777686 C04772 BX489036 CB044840 AA371021 BG741496 BM273036 CA418422 
    BU146609 AA386188 AW474951 CB044841 T93884 AI873547 AK095885 L01697 

    GeneLoc Exon Structure


    Expression
    for COL15A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COL15A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    COL15A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    AdiposeVisceral White AdiposeAdipose
    BrainChoroid PlexusBrain
    KidneyMetanephrosKidney
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See COL15A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COL15A1

    SOURCE GeneReport for Unigene cluster: Hs.409034

    UniProtKB/Swiss-Prot: COFA1_HUMAN, P39059
    Tissue specificity: Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including COL15A1: 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL15A1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL15A1

    Orthologs
    for COL15A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for COL15A1 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves COL15A11 collagen, type XV, alpha 1 66.2(n)
    65.83(a)    		   420803  XM_418896.3  XP_418896.3 
    lizard
    (Anolis carolinensis)    		 Reptilia COL15A16
    		 --
    		 54(a)
    		 1 ↔ 1
    		 6(55868862-55953501)
    zebrafish
    (Danio rerio)    		 Actinopterygii cmn6
    col15a1b6
    (see all 3)    		 collagen, type XV, alpha 1b
    (see all 3)    		 6(a)
    47(a)
    (see all 3)    		 possible ortholog
    1 ↔ 1
    (see all 3)    		 12(14224584-14270293)
    2(23850967-23927192)
    fruit fly
    (Drosophila melanogaster)    		 Insecta pygo6
    mp6
    		 multiplexin
    		 7(a)
    32(a)
    		 possible ortholog
    1 ↔ 1
    		 3R(27401557-27406412)
    3L(6991943-7046528)
    worm
    (Caenorhabditis elegans)    		 Secernentea cle-13 cle-1 isoform A 33(a)   I(8714046-8732339)   --


    ENSEMBL Gene Tree for COL15A1 (if available)
    TreeFam Gene Tree for COL15A1 (if available) 

    Paralogs
    for COL15A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COL15A1 gene
    COL18A12  

    COL15A1 for paralogs           About GeneDecksing



    Genomic Variants
    for COL15A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2389 NCBI SNPs in COL15A1 are shown (see all 2389)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1431876411,2
    		--101704201(+) TCCCTA/GTGGTT 1 -- us2k10--------
    rs1482628591,2
    		--101704338(+) AGTTCA/GCCTTA 1 -- us2k10--------
    rs745259841,2
    		F,--101704364(+) TGAGGC/ACAACC 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs785041181,2
    		F,--101704524(+) TGGACA/GGAGAG 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1813375811,2
    		--101704657(+) ACTTCA/GCCCTG 1 -- us2k10--------
    rs1869378241,2
    		--101704668(+) CAGCCA/GGGGCC 1 -- us2k10--------
    rs38245151,2
    		C,F,H,--101704737(-) TGGGCG/AGTGAG 1 -- us2k119Minor allele frequency- A:0.26NS EA NA WA 2340
    rs1917504031,2
    		--101704873(+) TGGGTC/GTTGCA 1 -- us2k10--------
    rs1412684521,2
    		--101704876(+) GTGTTG/TCATCT 1 -- us2k10--------
    rs1462357231,2
    		--101705064(+) CATTCC/TCATGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COL15A1 (101705461 - 101833069 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for COL15A1: --

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    Disorders / Diseases
    for COL15A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    COL15A1 for disorders           About GeneDecksing

    OMIM gene information: 120325    OMIM disorders: --

    1 disease for COL15A1:    About MalaCards
    dupuytren contracture

    Human Genome Epidemiology (HuGE) Navigator: COL15A1 (3 documents)

    Export disorders for COL15A1 gene to outside databases

    Publications
    for COL15A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COL15A1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with COL15A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22. (PubMed id 1427836)1, 2, 3 Huebner K.... Myers J.C. (1992)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    3. Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells. (PubMed id 10791950)1, 2 Li D.... Myers J.C. (2000)
    4. Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. (PubMed id 10049780)1, 2 Ramchandran R.... Sukhatme V.P. (1999)
    5. Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene. (PubMed id 9651385)1, 2 Haegg P.M.... Pihlajaniemi T. (1998)
    6. Primary structure of the alpha 1 chain of human type XV collagen and exon-intron organization in the 3' region of the corresponding gene. (PubMed id 8106446)1, 2 Kivirikko S....Pihlajaniemi T. (1994)
    7. The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen. (PubMed id 8307960)1, 2 Muragaki Y.... Ooshima A. (1994)
    8. Identification of a previously unknown human collagen chain, alpha 1(XV), characterized by extensive interruptions in the triple-helical region. (PubMed id 1279671)1, 2 Myers J.C.... Pihlajaniemi T. (1992)
    9. Extracellular calcium chronically induced human osteob lasts effects: specific modulation of osteocalcin and collagen type XV. (PubMed id 22034088)1 Gabusi E....Lisignoli G. (2012)
    10. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)2 Halim A.... Larson G. (2011)

    External Searches for COL15A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing COL15A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1306 HGNC: 2192 AceView: COL15A1 Ensembl:ENSG00000204291 euGenes: HUgn1306
    ECgene: COL15A1 Kegg: 1306 H-InvDB: COL15A1

    Other Databases showing COL15A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing COL15A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COL15A1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for COL15A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for COL15A1 gene:
    Search GeneIP for patents involving COL15A1

    GeneCards and IP:
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