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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COL14A1 Gene

protein-coding GIFtS: 56
GCID: GC08P121093

collagen, type XIV, alpha 1

(Previous name: undulin )
(Previous symbol: UND)

Explore 20 diseases affiliated with
COL14A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Collagen, Type XIV, Alpha 1¹ ²
UND¹ ² ³ ⁵
Undulin³
Collagen Alpha-1(XIV) Chain²
Undulin (Fibronectin-Tenascin-Related)²
Undulin³

External Ids:	HGNC: 2191¹	Entrez Gene: 7373²	Ensembl: ENSG00000187955⁷	OMIM: 120324⁵	UniProtKB: Q05707³

Export aliases for COL14A1 gene to outside databases

Previous GC identifers: GC08P120129 GC08P121129 GC08P120740 GC08P121028 GC08P121188 GC08P116458

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COL14A1:

This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with

interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in

the regulation of fibrillogenesis. (provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: COEA1_HUMAN, Q05707

Function: Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of

interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril

and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other

matrix molecules or cell surface receptors (By similarity)

Gene Wiki entry for COL14A1 (Collagen, type XIV, alpha 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COL14A1 gene promoter:
STAT5B AhR Pbx1a Lmo2 AP-4 Ik-3 c-Ets-1 Arnt AREB6 Nkx6-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COL14A1 promoter sequence

Search SABiosciences Chromatin IP Primers for COL14A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL14A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23 Ensembl cytogenetic band: 8q24.12 HGNC cytogenetic band: 8q23

COL14A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL14A1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P121093: view genomic region (about GC identifiers)

Start:	121,072,019 bp from pter	End:	121,384,275 bp from pter
Size:	312,257 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COEA1_HUMAN, Q05707 (See protein sequence)

Recommended Name: Collagen alpha-1(XIV) chain precursor

Size: 1796 amino acids; 193515 Da

Subunit: Homotrimer (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Sequence caution: Sequence=AAA36795.1; Type=Miscellaneous discrepancy; Sequence=AAH14640.1; Type=Frameshift;

Positions=1047;

Secondary accessions: B2RU07 O00260 O00261 O00262 Q05708 Q5XJ18 Q96C67 Q9UDF6

Alternative splicing: 3 isoforms: Q05707-1 Q05707-2 Q05707-3

Explore the universe of human proteins at neXtProt for COL14A1: NX_Q05707

Post-translational modifications:

Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind

carbohydrates (By similarity)¹

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains

(By similarity)¹

May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q05707

COL14A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_066933.1

ENSEMBL proteins:

ENSP00000428851 ENSP00000311809 ENSP00000297848 ENSP00000429123 ENSP00000409461

ENSP00000403640 ENSP00000247781 ENSP00000443974

Reactome Protein details: Q05707
Human Recombinant Protein Products for COL14A1:

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	Novus Biologicals COL14A1 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	NAS	2187872
GO:0005581	collagen	NAS	9427527
GO:0005596	collagen type XIV	NAS	9427527
GO:0005615	extracellular space	IDA	--

COL14A1 for ontologies About GeneDecksing

COL14A1 Antibody Products:

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	Novus Biologicals COL14A1 Antibodies
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	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for COL14A1

Assay Products for COL14A1:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COL14A1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003961 Fibronectin_type3

IPR001791 Laminin_G

IPR013783 Ig-like_fold

IPR008160 Collagen

IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry Q05707

ProtoNet protein and cluster: Q05707

3 Blocks protein families:

IPB003129 Thrombospondin

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: COEA1_HUMAN, Q05707

Similarity: Belongs to the fibril-associated collagens with interrupted helices (FACIT) family

Similarity: Contains 4 collagen-like domains

Similarity: Contains 8 fibronectin type-III domains

Similarity: Contains 1 laminin G-like domain

Similarity: Contains 2 VWFA domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: COEA1_HUMAN, Q05707

Function: Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of

interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril

and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other

matrix molecules or cell surface receptors (By similarity)

Genatlas biochemistry entry for COL14A1:

collagen,type XIV,alpha 1,fibril-associated collagen with interrupted triple helices (FACIT) homotrimerizing,expressed

in extracellular matrix,related to collagen type XIV,involved in supramolecular organization of fibril bundles

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	NAS	9427527
GO:0005518	collagen binding	NAS	2187872
GO:0030674	protein binding, bridging	NAS	9427527

COL14A1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for COL14A1:

Increased gamma-H2AX phosphory

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Col14a1):

integument

muscle

skeleton

COL14A1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Col14a1^tm1Debi for COL14A1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for COL14A1

miRNA Products:		OriGene 3'-UTR Clone: COL14A1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL14A1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate COL14A1 (see all 12):
		hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-196a hsa-let-7e hsa-let-7g hsa-let-7b

		SwitchGear 3'UTR luciferase reporter plasmid: COL14A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL14A1 (see all 7) OriGene shRNA RFP: COL14A1 OriGene siRNA: COL14A1
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for COL14A1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COL14A1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COL14A1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COL14A1 (NM_021110)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COL14A1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL14A1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Collagen formation

	Collagen formation	1.00			Extracellular matrix organization	0.54
	Collagen biosynthesis and modifying enzymes	0.74			Secretion of collagens	0.49

Degradation of the extracellular matrix

Degradation of the extracellular matrix

1.00

Degradation of collagen

0.79

Blood Coagulation Cascade

Blood Coagulation Cascade

1.00

Intrinsic Prothrombin Activation Pathway

0.96

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL14A1 (see all 15)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

5/6 Reactome Pathways for COL14A1 (see all 6)

	Extracellular matrix organization
	Secretion of collagens
	Collagen biosynthesis and modifying enzymes
	Degradation of the extracellular matrix
	Collagen formation

1 Kegg Pathway (Kegg details for COL14A1):

Protein digestion and absorption

COL14A1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for COL14A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/43 Interacting proteins for COL14A1 (Q05707³ ENSP00000297848⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 43)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DCN	P07585³, ENSP00000052754⁴	I2D: score=2 STRING: ENSP00000052754
CD44	P16070³, ENSP00000278385⁴	I2D: score=2 STRING: ENSP00000278385
COL11A1	ENSP00000351163⁴	STRING: ENSP00000351163
COL12A1	ENSP00000325146⁴	STRING: ENSP00000325146
COL13A1	ENSP00000348695⁴	STRING: ENSP00000348695

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016337	cell-cell adhesion	NAS	9427527
GO:0030198	extracellular matrix organization	TAS	--
GO:0030199	collagen fibril organization	NAS	2187872

COL14A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

COL14A1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COL14A1
2 Novoseek chemical compound relationships for COL14A1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
procollagen	66.7	5	1602407 (2), 7510338 (1), 7536506 (1), 12003913 (1)
hyaluronic acid	28.7	2	12003913 (1)

Search CenterWatch for drugs/clinical trials and news about COL14A1 / COEA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COL14A1 gene:

NM_021110.2

Unigene Cluster for COL14A1:

Collagen, type XIV, alpha 1

Hs.409662 [show with all ESTs]

Unigene Representative Sequence: NM_021110

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000498051 ENST00000309791(uc003yoz.3) ENST00000297848(uc003yox.3)

ENST00000432943(uc003yoy.3) ENST00000523142 ENST00000434620 ENST00000440844

ENST00000247781(uc010mde.1) ENST00000537875

miRNA Products:		OriGene 3'-UTR Clone: COL14A1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL14A1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate COL14A1 (see all 12):
		hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-196a hsa-let-7e hsa-let-7g hsa-let-7b

		SwitchGear 3'UTR luciferase reporter plasmid: COL14A1 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL14A1 (see all 7) OriGene shRNA RFP: COL14A1 OriGene siRNA: COL14A1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against COL14A1

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		GenScript: all cDNA clones in your preferred vector: COL14A1 (NM_021110)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL14A1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL14A1

Additional cDNA sequence:

AK293080.1 AK307716.1 AK311498.1 BC014640.1 BC036192.1 BC083495.1 BC140893.1 M64108.1

M64109.1 Y11709.1 Y11710.1 Y11711.1

9 DOTS entries:

DT.316526 DT.95166350 DT.100677241 DT.100777157 DT.101969867 DT.92342243 DT.92016567 DT.91738610

DT.91962898

24/163 AceView cDNA sequences (see all 163):

AI468483 AL553343 BX098443 CR614438 CA773792 M64108 AA723199 AI240724

AA903698 BX102572 BM728804 BE895297 AK021997 BF844580 BM728358 BG695965

AI085061 BX479647 AL544493 AA910046 BQ717750 CA394080 AI755035 BF434696

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COL14A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGATAAGTT

About this image

COL14A1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Selective marker (cell-identifying gene)

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Tendons & Ligaments

Axial Tendon Primordia

Early Tenocyte Cells

Tendons & Ligaments

Axial Tendons and Ligamnets

Tenocytes

Tendons & Ligaments

Limb Tendon Primordia

Early Tenocyte Cells

Tendons & Ligaments

Limb Tendons and Ligamnets

Tenocytes

Tendons & Ligaments

Gut Tube

Hindgut

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Alveolar type II cells (Derivation of mature...)

Lung

See COL14A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COL14A1

SOURCE GeneReport for Unigene cluster: Hs.409662

SABiosciences Expression via Pathway-Focused PCR Arrays including COL14A1:

Osteogenesis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Wound Healing in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COL14A1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat COL14A1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL14A1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL14A1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL14A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for COL14A1 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	COL14A1¹	collagen, type XIV, alpha 1	74.61(n) 76.75(a)		396276 NM_205334.1 NP_990665.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	70(a) 43(a)	1 ↔ many 1 ↔ many	GL343269.1(1276114-1385487) GL344379.1(12733-33187)
zebrafish (Danio rerio)	Actinopterygii	wufb93g03²	Transcribed sequence with weak similarity to protein more	72.26(n)		CA475879.1

ENSEMBL Gene Tree for COL14A1 (if available)
TreeFam Gene Tree for COL14A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for COL14A1 gene

VWA1² MATN4² COL9A1² MATN3² MATN2² COL12A1² VIT² COL9A3²

COCH² COL9A2² COL20A1² VWA2² COL21A1² MATN1²

12 SIMAP similar genes for COL14A1 using alignment to 6 protein entries: COEA1_HUMAN (see all proteins):

COL12A1 COL21A1 ITGA2 COL11A2 COL10A1 COL1A1

COL27A1 EMID1 MSR1 COL4A3 COL7A1 SFTPD

COL14A1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for COL14A1
PGOHUM00000250230 PGOHUM00000250231

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147015992^1,2		--	121135500(+)	`GCTAGA/TTTTTG`	1	--	us2k¹		0	--	--	--	--
rs138016782^1,2		--	121135555(+)	`CTCGAA/TCTCCT`	1	--	us2k¹		0	--	--	--	--
rs182254067^1,2		--	121135736(+)	`GATAGA/GCACTT`	1	--	us2k¹		0	--	--	--	--
rs77384360^1,2	C	--	121135750(+)	`TGGGGG/TCAGAG`	1	--	us2k¹		3		NA WA	240
rs111432200^1,2	C,F	--	121135766(+)	`GAGATC/ATAACT`	1	--	us2k¹		3		NA CSA WA	122
rs149512840^1,2		--	121135785(+)	`GATTGC/TCTTCA`	1	--	us2k¹		0	--	--	--	--
rs187872150^1,2		--	121135799(+)	`ATAAAC/GACTGC`	1	--	us2k¹		0	--	--	--	--
rs74797674^1,2	C,F	--	121135814(+)	`CAGGAA/GTTCTA`	1	--	us2k¹		2		WA EA	238
rs13277847^1,2	H	--	121135916(+)	`GCAGTC/GCTTGG`	1	--	us2k¹		4		NS EA	410
rs77101516^1,2	C	--	121135928(+)	`GTCGGA/CGCGGG`	1	--	us2k¹		4		NA WA EA	360

HapMap Linkage Disequilibrium report for COL14A1 (121072019 - 121322019 bp, first 250kb of COL14A1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COL14A1: --
Human Gene Mutation Database (HGMD): COL14A1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COL14A1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COL14A1 for disorders           About GeneDecksing

OMIM gene information: 120324    OMIM disorders: --

20 diseases for COL14A1:    About MalaCards

lichen planus odontogenic myxoma oral lichen planus alcoholic liver cirrhosis

collagenous colitis liver cirrhosis myxoma polycystic kidney disease

kidney disease liver fibrosis schistosomiasis keloids

acute pancreatitis liver disease fibrosis alcoholism

periodontitis pancreatitis adenocarcinoma hepatitis

4 Novoseek disease relationships for COL14A1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
collagen fibril	67.7	11	2187872 (3), 7678270 (2), 9477307 (1), 10417515 (1) (see all 7)
liver fibrosis	61.6	4	8135774 (1), 17688172 (1), 12003913 (1), 7523266 (1)
cirrhosis	8.45	1	17688172 (1)
hyperplasia	3.93	3	7510338 (2), 7540204 (1)

Human Genome Epidemiology (HuGE) Navigator: COL14A1 (2 documents)

Export disorders for COL14A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for COL14A1 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with COL14A1)

Utopia: connect your pdf to the dynamic
world of online information

Undulin is a novel member of the fibronectin-tenascin family of extracellular matrix glycoproteins. (PubMed id 1716629)^{1, 2, 3, 9} Just M....Schuppan D. (1991)
Complete primary structure of human collagen type XIV (undulin). (PubMed id 9427527)^{1, 2, 3, 9} Bauer M....Schuppan D. (1997)
Undulin, an extracellular matrix glycoprotein associated with collagen fibrils. (PubMed id 2187872)^{1, 2, 9} Schuppan D.... Hahn E. (1990)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)^{1, 2} Nusbaum C....Lander E.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Regulation of undulin synthesis and gene expression in human fat-storing cells by acetaldehyde and transforming growth factor-beta 1: comparison with fibronectin. (PubMed id 8135774)^{1, 9} Casini A....Surrenti C. (1994)
The COL12A1 and COL14A1 genes and Achilles tendon injuries. (PubMed id 17960519)^{1, 9} September A.V....Collins M. (2008)
Comparative cytogenetic mapping of COL14A1, the gene for human and mouse collagen XIV. (PubMed id 10393435)^{1, 9} Imhof M. and Trueb B. (1999)
[Age-dependent distribution of collagen and glycoproteins in the blood vessels of the human uterine tube] (PubMed id 9092299)^{1, 9} Gopel C....Schuppan D. (1997)
Localization of the undulin gene (UND) to human chromosome band 8q23. (PubMed id 7842743)^{1, 9} Schnittger S....Fonatsch C. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7373	HGNC: 2191	AceView: COL14A1	Ensembl:ENSG00000187955	euGenes: HUgn7373
ECgene: COL14A1	Kegg: 7373	H-InvDB: COL14A1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for COL14A1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for COL14A1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for COL14A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for COL14A1 gene:
Search GeneIP for patents involving COL14A1

GeneCards and IP:
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COL14A1 Gene

collagen, type XIV, alpha 1

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COL14A1 Gene

collagen, type XIV, alpha 1

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