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Aliases for COIL Gene

Aliases for COIL Gene

  • Coilin 2 3
  • CLN80 3 4 6
  • P80-Coilin 3 4
  • Coilin P80 3
  • P80 3

External Ids for COIL Gene

Summaries for COIL Gene

Entrez Gene Summary for COIL Gene

  • The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

GeneCards Summary for COIL Gene

COIL (Coilin) is a Protein Coding gene. Diseases associated with COIL include ischemic neuropathy and differentiating neuroblastoma. GO annotations related to this gene include identical protein binding and disulfide oxidoreductase activity.

UniProtKB/Swiss-Prot for COIL Gene

  • Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.

Gene Wiki entry for COIL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COIL Gene

Genomics for COIL Gene

Genomic Location for COIL Gene

Start:
56,938,187 bp from pter
End:
56,961,054 bp from pter
Size:
22,868 bases
Orientation:
Minus strand

Genomic View for COIL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COIL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COIL Gene

Regulatory Elements for COIL Gene

Proteins for COIL Gene

  • Protein details for COIL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P38432-COIL_HUMAN
    Recommended name:
    Coilin
    Protein Accession:
    P38432
    Secondary Accessions:
    • B2R931

    Protein attributes for COIL Gene

    Size:
    576 amino acids
    Molecular mass:
    62608 Da
    Quaternary structure:
    • Interacts with ANKS1B. Interacts with SMN (via Tudor domain). Interacts (via C-terminus) with AK6.

neXtProt entry for COIL Gene

Proteomics data for COIL Gene at MOPED

Post-translational modifications for COIL Gene

  • Phosphorylation during mitosis is associated with disassembly of CBs.
  • Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys555

Other Protein References for COIL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COIL Gene

Domains for COIL Gene

Protein Domains for COIL Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

COIL_HUMAN
Domain:
  • The atypical Tudor domain at the C-terminus contains two large unstructured loops, and does not bind methylated residues.:
    • P38432
  • Contains 1 Tudor domain.:
    • P38432
Family:
  • Belongs to the coilin family.:
    • P38432
genes like me logo Genes that share domains with COIL: view

No data available for Gene Families for COIL Gene

Function for COIL Gene

Molecular function for COIL Gene

GENATLAS Biochemistry: coilin,protein of the non-capsular nuclear bodies (coiled bodies),in interphase cells,80kDa
UniProtKB/Swiss-Prot Function: Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.

Gene Ontology (GO) - Molecular Function for COIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12757932
GO:0008022 protein C-terminus binding IPI 12757932
GO:0042802 identical protein binding IPI 16713569
genes like me logo Genes that share ontologies with COIL: view

Phenotypes for COIL Gene

genes like me logo Genes that share phenotypes with COIL: view

Animal Models for COIL Gene

MGI Knock Outs for COIL:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for COIL Gene

Localization for COIL Gene

Subcellular locations from UniProtKB/Swiss-Prot for COIL Gene

Nucleus. Nucleus, Cajal body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COIL Gene COMPARTMENTS Subcellular localization image for COIL gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for COIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA 12757932
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0015030 Cajal body IDA 12757932
genes like me logo Genes that share ontologies with COIL: view

Compounds for COIL Gene

(8) Novoseek inferred chemical compound relationships for COIL Gene

Compound -log(P) Hits PubMed IDs
actinomycin d 39.7 3
okadaic acid 19.6 1
rrna 12.7 1
arginine 6.85 1
aspartate 4.85 2
genes like me logo Genes that share compounds with COIL: view

Transcripts for COIL Gene

mRNA/cDNA for COIL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(175) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COIL Gene

Coilin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COIL Gene

No ASD Table

Relevant External Links for COIL Gene

GeneLoc Exon Structure for
COIL
ECgene alternative splicing isoforms for
COIL

Expression for COIL Gene

mRNA expression in normal human tissues for COIL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COIL Gene

This gene is overexpressed in Testis (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COIL Gene

SOURCE GeneReport for Unigene cluster for COIL Gene Hs.532795

mRNA Expression by UniProt/SwissProt for COIL Gene

P38432-COIL_HUMAN
Tissue specificity: Found in all the cell types examined
genes like me logo Genes that share expressions with COIL: view

Orthologs for COIL Gene

This gene was present in the common ancestor of chordates.

Orthologs for COIL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COIL 36
  • 99.36 (n)
  • 99.13 (a)
COIL 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COIL 36
  • 82.48 (n)
  • 75.84 (a)
COIL 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COIL 36
  • 82.96 (n)
  • 75.3 (a)
COIL 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coil 36
  • 74.69 (n)
  • 66.96 (a)
Coil 16
Coil 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COIL 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COIL 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coil 36
  • 75.01 (n)
  • 66.14 (a)
chicken
(Gallus gallus)
Aves COIL 37
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COIL 37
  • 38 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397940 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7255 36
zebrafish
(Danio rerio)
Actinopterygii coil 36
coil 37
  • 37 (a)
OneToOne
Species with no ortholog for COIL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COIL Gene

ENSEMBL:
Gene Tree for COIL (if available)
TreeFam:
Gene Tree for COIL (if available)

Paralogs for COIL Gene

Pseudogenes.org Pseudogenes for COIL Gene

genes like me logo Genes that share paralogs with COIL: view

No data available for Paralogs for COIL Gene

Variants for COIL Gene

Sequence variations from dbSNP and Humsavar for COIL Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8599 -- 56,938,497(-) TCAGG(G/T)CCCTG utr-variant-3-prime
rs1042237 -- 56,938,861(-) TAATT(A/T)CAGTT utr-variant-3-prime
rs1042238 -- 56,938,799(-) GGTTT(A/C)TTCTC utr-variant-3-prime
rs1042239 -- 56,938,796(-) TTCTT(A/C)TCTTT utr-variant-3-prime
rs1042240 -- 56,938,782(-) TAAAT(C/G)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for COIL Gene

Variant ID Type Subtype PubMed ID
esv32884 CNV Loss 17666407

Relevant External Links for COIL Gene

HapMap Linkage Disequilibrium report
COIL

Disorders for COIL Gene

(3) University of Copenhagen DISEASES for COIL Gene

(4) Novoseek inferred disease relationships for COIL Gene

Disease -log(P) Hits PubMed IDs
muscular atrophy spinal 76.4 1
sclerosis systemic 24.8 1
leukemia 6.41 1
lupus erythematosus systemic 4.87 1

Relevant External Links for COIL

Genetic Association Database (GAD)
COIL
Human Genome Epidemiology (HuGE) Navigator
COIL
genes like me logo Genes that share disorders with COIL: view

No data available for UniProtKB/Swiss-Prot for COIL Gene

Publications for COIL Gene

  1. Structure, expression and chromosomal localization of human p80- coilin gene. (PMID: 7971277) Chan E.K.L. … Matera A.G. (Nucleic Acids Res. 1994) 2 3 4 23
  2. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. (PMID: 2033369) Andrade L.E.C. … Tan E.M. (J. Exp. Med. 1991) 3 4 23
  3. Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis -- evidence that the coiled body is a kinetic nuclear structure. (PMID: 7679389) Carmo-Fonseca M. … Lamond A.I. (J. Cell Biol. 1993) 3 4 23
  4. Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein. (PMID: 11641277) Hebert M.D. … Matera A.G. (Genes Dev. 2001) 3 4 23
  5. Coilin methylation regulates nuclear body formation. (PMID: 12361597) Hebert M.D. … Matera A.G. (Dev. Cell 2002) 3 4 23

Products for COIL Gene

  • Addgene plasmids for COIL

Sources for COIL Gene

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