External Ids for COIL Gene
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]
GeneCards Summary for COIL Gene
COIL (Coilin) is a Protein Coding gene. Diseases associated with COIL include ischemic neuropathy and differentiating neuroblastoma. GO annotations related to this gene include identical protein binding and disulfide oxidoreductase activity.
UniProtKB/Swiss-Prot for COIL Gene
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.