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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COIL Gene

protein-coding   GIFtS: 53
GCID: GC17M055015

coilin
 Explore 15 diseases affiliated with
COIL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for COIL    

Aliases
for COIL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Coilin1
CLN801 2 3 5
P80-Coilin1
P801
Coilin P802

External Ids:    HGNC: 21841   Entrez Gene: 81612   Ensembl: ENSG000001210587   OMIM: 6002725   UniProtKB: P384323   

Export aliases for COIL gene to outside databases

Previous GC identifers: GC17M054752 GC17M057497 GC17M055357 GC17M055490 GC17M052370 GC17M050376


Summaries
for COIL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for COIL:
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are
nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of
small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while
the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and
phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of
Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: COIL_HUMAN, P38432
Function: Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly
of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80
coilin

Gene Wiki entry for COIL (Coilin)


Genomic Views
for COIL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COIL gene promoter:
         SRF   TBP   AP-1   SRF (504 AA)   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COIL promoter sequence
   Search SABiosciences Chromatin IP Primers for COIL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COIL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

COIL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COIL gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M055015:  view genomic region     (about GC identifiers)

Start:
 55,015,548 bp from pter      End:
 55,038,415 bp from pter
Size:
 22,868 bases      Orientation:
 minus strand

Proteins
for COIL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: COIL_HUMAN, P38432 (See protein sequence)
Recommended Name: Coilin  
Size: 576 amino acids; 62608 Da
Subunit: Interacts with ANKS1B
Subcellular location: Nucleus. Note=Nuclear coiled body located in the interchromatin space between the nucleolus and
the nucleus
Secondary accessions: B2R931

Explore the universe of human proteins at neXtProt for COIL: NX_P38432

Post-translational modifications:

  • Symmetrical dimethylation of arginine residues within the RG repeat region modulates affinity for SMN, and thus,
    • localization of SMN complexes to the nuclear coiled bodies1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P38432

    • COIL Protein expression data from MOPED and PaxDb:    About this image 
    COIL Protein Expression
    REFSEQ proteins: NP_004636.1  
    ENSEMBL proteins: 
     ENSP00000240316   ENSP00000460217  

    Human Recombinant Protein Products for COIL: 
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    OriGene Protein Over-expression Lysate: COIL
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    Novus Biologicals COIL Protein
    Novus Biologicals COIL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for COIL

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001674female germ cell nucleus IEA--
    GO:0005634nucleus TAS7971277
    GO:0005654nucleoplasm IDA12757932
    GO:0005730nucleolus IDA12757932
    GO:0015030Cajal body IDA16687569

    COIL for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for COIL

    Protein Domains /
    Families
    for COIL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    COIL for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR024822 Coilin

    Graphical View of Domain Structure for InterPro Entry P38432

    ProtoNet protein and cluster: P38432

    UniProtKB/Swiss-Prot: COIL_HUMAN, P38432
    Domain: The atypical Tudor domain at the C-terminus contains two large unstructured loops, and doesn't bind methylated
    residues
    Similarity: Belongs to the coilin family
    Similarity: Contains 1 Tudor domain


    Function
    for COIL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COIL_HUMAN, P38432
    Function: Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly
    of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80
    coilin

         Genatlas biochemistry entry for COIL:
    coilin,protein of the non-capsular nuclear bodies (coiled bodies),in interphase cells,80kDa

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008022protein C-terminus binding IPI12757932
    GO:0015036disulfide oxidoreductase activity IEA--
    GO:0042802identical protein binding IPI16713569
         
    COIL for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Coil):
     cellular  mortality/aging 

    COIL for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Coiltm1Agm for COIL
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for COIL 

    miRNA
    Products:            		miRTarBase miRNAs that target COIL:
    hsa-mir-1 (MIRT001376)

    OriGene 3'-UTR Clone: COIL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COIL
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate COIL (see all 21):
    hsa-let-7d hsa-miR-202 hsa-miR-488 hsa-let-7c hsa-miR-500a hsa-let-7g hsa-let-7a hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmid: COIL 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COIL (see all 7)
    OriGene shRNA RFP: COIL
    OriGene siRNA: COIL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COIL
    Sirion Biotech Custom design and validation of potent shRNA sequences against COIL 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of COIL 
    Sirion Biotech Customized adenovirus for potent knockdown of COIL

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: COIL (NM_004645)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COIL 

    Cell Line
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    Search LifeMap BioReagents cell lines for COIL
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    Sirion Biotech Customized inducible overexpressing cell line services for COIL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COIL


    Pathways & Interactions
    for COIL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COIL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/102 Interacting proteins for COIL (P384321, 2, 3 ENSP000002403164) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP70Q8NHQ11, 2, 3, ENSP000002649824EBI-945751,EBI-739624 MINT-2876726 MINT-2876707 I2D: score=3 STRING: ENSP00000264982
    LNX1Q8TBB11, 2, 3, ENSP000002639254EBI-945751,EBI-739832 MINT-2877433 MINT-2855463 I2D: score=3 STRING: ENSP00000263925
    XRCC5P130102, 3MINT-8052957 MINT-8052894 MINT-8052908 MINT-8052786 MINT-8052765 MINT-8052804 I2D: score=1 
    C1QBPQ070212, 3, ENSP000002256984MINT-2857249 MINT-2857268 I2D: score=3 STRING: ENSP00000225698
    KALRNO602292, 3, ENSP000002408744MINT-2865680 MINT-2865661 I2D: score=3 STRING: ENSP00000240874
    About this table

    Drugs & Compounds
    for COIL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    COIL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COIL
    8 Novoseek chemical compound relationships for COIL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actinomycin d 39.7 3 8612682 (2), 10751146 (1)
    okadaic acid 19.6 1 9013710 (1)
    rrna 12.7 2 9112227 (1)
    arginine 6.85 1 12486110 (1)
    aspartate 4.85 3 9013710 (1), 9743589 (1)
    cycloheximide 3.2 1 10512877 (1)
    pyruvate 0 3 10512877 (1), 9699418 (1)
    serine 0 3 9013710 (1), 9743589 (1)

    Search CenterWatch for drugs/clinical trials and news about COIL 

    Transcripts
    for COIL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for COIL gene: 
    NM_004645.2  

    Unigene Cluster for COIL:

    Coilin
    Hs.532795  [show with all ESTs]
    Unigene Representative Sequence: BC010385
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240316(uc002iuu.3) ENST00000573008

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COIL
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate COIL (see all 21):
    hsa-let-7d hsa-miR-202 hsa-miR-488 hsa-let-7c hsa-miR-500a hsa-let-7g hsa-let-7a hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmid: COIL 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COIL (see all 7)
    OriGene shRNA RFP: COIL
    OriGene siRNA: COIL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COIL
    Sirion Biotech Custom design and validation of potent shRNA sequences against COIL 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COIL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: COIL (NM_004645)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COIL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COIL 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COIL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COIL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COIL

    Additional cDNA sequence: 

    AK313616.1 BC010385.1 M58411.1 U06632.1 

    9 DOTS entries:

    DT.117156  DT.100692058  DT.100714986  DT.100769597  DT.100806895  DT.100806898  DT.100806899  DT.40106002 
    DT.120950534 

    24/175 AceView cDNA sequences (see all 175):

    BM090923 AI650860 BQ001448 AW134642 N58051 AI458844 AW593021 BM479169 
    CB215276 AA977067 BX379049 BG329408 BM978288 BF445836 BF939452 BX365683 
    BU618421 AL041190 BF222423 CB853192 AI216471 CR605137 AA128900 CR611341 

    GeneLoc Exon Structure


    Expression
    for COIL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COIL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTATTTGACC
    COIL Expression
    About this image

    COIL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See COIL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COIL

    SOURCE GeneReport for Unigene cluster: Hs.532795

    UniProtKB/Swiss-Prot: COIL_HUMAN, P38432
    Tissue specificity: Found in all the cell types examined

        SABiosciences Custom PCR Arrays for COIL
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COIL

    Orthologs
    for COIL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for COIL gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Coil1 , 5 coilin1, 5 74.69(n)1
    66.96(a)1    		   11 (54.34 cM)5
    128121  NM_016706.21  NP_057915.21 
     889702525 
    chicken
    (Gallus gallus)    		 Aves COIL1 coilin 51.85(n)
    43.53(a)    		   417402  XM_415654.3  XP_415654.3 
    lizard
    (Anolis carolinensis)    		 Reptilia COIL6
    		 --
    		 38(a)
    		 1 ↔ 1
    		 GL343198.1(683283-691699)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3979402 sphere organelle protein sph-1 76.41(n)    Z23011.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii coil2 coilin p80 73.83(n)   58024  BC045858.1 


    ENSEMBL Gene Tree for COIL (if available)
    TreeFam Gene Tree for COIL (if available) 

    Paralogs
    for COIL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COIL gene

    COIL for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for COIL
    PGOHUM00000247779 PGOHUM00000246064


    Genomic Variants
    for COIL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/464 NCBI SNPs in COIL are shown (see all 464)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1924528711,2
    		--55015151(+) AACTGA/GTAATA 1 -- ds50010--------
    rs1154087891,2
    		F--55015160(+) TAATCT/CGAGAA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs728423281,2
    		C,F--55015218(+) TATCTT/CAATTT 1 -- ds50013Minor allele frequency- C:0.02WA NA EA 358
    rs1840778971,2
    		--55015358(+) ACATTA/CATGTC 1 -- ds50010--------
    rs1396598361,2
    		--55015378(+) AAAACC/TGGCCA 1 -- ds50010--------
    rs1444243931,2
    		--55015641(+) TTTCAC/TGGTAT 1 -- ut310--------
    rs1510976371,2
    		--55015810(+) CTCCAC/GGCATA 1 -- ut310--------
    rs1881815981,2
    		--55015838(+) CTTATC/TTTCAC 1 -- ut310--------
    rs85991,2
    		C,F--55015858(-) TCAGGT/GCCCTG 1 -- ut31 ese35Minor allele frequency- G:0.01MN NA WA CSA 191
    rs1931736871,2
    		--55015875(+) TTAATC/TTTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for COIL (55015548 - 55038415 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for COIL
         1 CNV: 7166

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COIL
    DNA2.0 Custom Variant and Variant Library Synthesis for COIL

    Disorders / Diseases
    for COIL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    COIL for disorders           About GeneDecksing

    OMIM gene information: 600272    OMIM disorders: --

    15 diseases for COIL:    About MalaCards
    spinal muscular atrophy    muscular atrophy    primary biliary cirrhosis    lupus erythematosus
    systemic lupus erythematosus    differentiating neuroblastoma    ischemic neuropathy    atopic dermatitis
    dermatitis    neuroblastoma    influenza    ataxia
    leukemia    neuronitis    vaccinia

    3 diseases from the University of Copenhagen DISEASES database for COIL:
    Muscular atrophy     Ischemic neuropathy     Spinal muscular atrophy

    4 Novoseek disease relationships for COIL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular atrophy spinal 76.4 1 11641277 (1)
    sclerosis systemic 24.8 1 7604300 (1)
    leukemia 6.41 1 15955076 (1)
    lupus erythematosus systemic 4.87 1 7604300 (1)

    Human Genome Epidemiology (HuGE) Navigator: COIL (15 documents)

    Export disorders for COIL gene to outside databases

    Publications
    for COIL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COIL gene, integrated from 9 sources (see all 154):
    (articles sorted by number of sources associating them with COIL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, expression and chromosomal localization of human p80- coilin gene. (PubMed id 7971277)1, 2, 3, 9 Chan E.K.L.... Matera A.G. (1994)
    2. Coilin methylation regulates nuclear body formation. (PubMed id 12361597)1, 2, 9 Hebert M.D....Matera A.G. (2002)
    3. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. (PubMed id 2033369)1, 2, 9 Andrade L.E.C....Tan E.M. (1991)
    4. Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis -- evidence that the coiled body is a kinetic nuclear structure. (PubMed id 7679389)1, 2, 9 Carmo-Fonseca M.... Lamond A.I. (1993)
    5. Solution structure of the carboxy-terminal Tudor doma in from human Coilin. (PubMed id 20875822)1, 2 Shanbhag R....Donaldson L.W. (2010)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. (PubMed id 15862129)1, 2 Xu H. and Hebert M.D. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Coilin phosphorylation mediates interaction with SMN and SmB'. (PubMed id 19997741)1, 9 Toyota C.G....Hebert M.D. (2010)

    External Searches for COIL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing COIL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8161 HGNC: 2184 AceView: COIL Ensembl:ENSG00000121058 euGenes: HUgn8161
    ECgene: COIL H-InvDB: COIL

    Other Databases showing COIL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing COIL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COIL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for COIL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for COIL gene:
    Search GeneIP for patents involving COIL

    GeneCards and IP:
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