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Aliases for COIL Gene

Aliases for COIL Gene

  • Coilin 2 3
  • P80-Coilin 3 4
  • CLN80 3 4
  • Coilin P80 3
  • P80 3

External Ids for COIL Gene

Previous GeneCards Identifiers for COIL Gene

  • GC17M054752
  • GC17M057497
  • GC17M055357
  • GC17M055490
  • GC17M052370
  • GC17M055015
  • GC17M050376

Summaries for COIL Gene

Entrez Gene Summary for COIL Gene

  • The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

GeneCards Summary for COIL Gene

COIL (Coilin) is a Protein Coding gene. Diseases associated with COIL include ischemic neuropathy and spinal muscular atrophy. Among its related pathways are Translational Control. GO annotations related to this gene include identical protein binding and protein C-terminus binding.

UniProtKB/Swiss-Prot for COIL Gene

  • Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.

Gene Wiki entry for COIL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COIL Gene

Genomics for COIL Gene

Regulatory Elements for COIL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COIL Gene

Chromosome:
17
Start:
56,938,187 bp from pter
End:
56,961,054 bp from pter
Size:
22,868 bases
Orientation:
Minus strand

Genomic View for COIL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COIL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COIL Gene

Proteins for COIL Gene

  • Protein details for COIL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P38432-COIL_HUMAN
    Recommended name:
    Coilin
    Protein Accession:
    P38432
    Secondary Accessions:
    • B2R931

    Protein attributes for COIL Gene

    Size:
    576 amino acids
    Molecular mass:
    62608 Da
    Quaternary structure:
    • Interacts with ANKS1B. Interacts with SMN (via Tudor domain). Interacts (via C-terminus) with AK6.

neXtProt entry for COIL Gene

Proteomics data for COIL Gene at MOPED

Post-translational modifications for COIL Gene

  • Phosphorylation during mitosis is associated with disassembly of CBs.
  • Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs
  • Ubiquitination at Lys 555
  • Modification sites at PhosphoSitePlus

Other Protein References for COIL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for COIL (coilin)

No data available for DME Specific Peptides for COIL Gene

Domains & Families for COIL Gene

Protein Domains for COIL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for COIL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P38432

UniProtKB/Swiss-Prot:

COIL_HUMAN :
  • The atypical Tudor domain at the C-terminus contains two large unstructured loops, and does not bind methylated residues.
  • Belongs to the coilin family.
Domain:
  • The atypical Tudor domain at the C-terminus contains two large unstructured loops, and does not bind methylated residues.
  • Contains 1 Tudor domain.
Family:
  • Belongs to the coilin family.
genes like me logo Genes that share domains with COIL: view

No data available for Gene Families for COIL Gene

Function for COIL Gene

Molecular function for COIL Gene

GENATLAS Biochemistry:
coilin,protein of the non-capsular nuclear bodies (coiled bodies),in interphase cells,80kDa
UniProtKB/Swiss-Prot Function:
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.

Gene Ontology (GO) - Molecular Function for COIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12757932
GO:0008022 protein C-terminus binding IPI 12757932
GO:0015036 disulfide oxidoreductase activity IEA --
GO:0042802 identical protein binding IPI 16713569
genes like me logo Genes that share ontologies with COIL: view

Phenotypes for COIL Gene

genes like me logo Genes that share phenotypes with COIL: view

Animal Models for COIL Gene

MGI Knock Outs for COIL:

Animal Model Products

miRNA for COIL Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for COIL Gene

Localization for COIL Gene

Subcellular locations from UniProtKB/Swiss-Prot for COIL Gene

Nucleus. Nucleus, Cajal body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COIL Gene COMPARTMENTS Subcellular localization image for COIL gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for COIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001674 female germ cell nucleus IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA 12757932
GO:0005730 nucleolus IDA 12757932
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with COIL: view

Pathways & Interactions for COIL Gene

SuperPathways for COIL Gene

Superpath Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with COIL: view

Pathways by source for COIL Gene

1 Cell Signaling Technology pathway for COIL Gene

SIGNOR curated interactions for COIL Gene

Is activated by:

Gene Ontology (GO) - Biological Process for COIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with COIL: view

Drugs & Compounds for COIL Gene

(4) Drugs for COIL Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
okadaic acid Experimental Pharma 0
arginine Nutra 346
pyruvate Nutra 27
serine Nutra 420

(4) Additional Compounds for COIL Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Actinomycin D
aspartate
Cycloheximide
rRNA
genes like me logo Genes that share compounds with COIL: view

Transcripts for COIL Gene

mRNA/cDNA for COIL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(175) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COIL Gene

Coilin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COIL Gene

No ASD Table

Relevant External Links for COIL Gene

GeneLoc Exon Structure for
COIL
ECgene alternative splicing isoforms for
COIL

Expression for COIL Gene

mRNA expression in normal human tissues for COIL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COIL Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for COIL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.3), Testis (12.3), Monocytes (10.1), and Breast (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COIL Gene



SOURCE GeneReport for Unigene cluster for COIL Gene Hs.532795

mRNA Expression by UniProt/SwissProt for COIL Gene

P38432-COIL_HUMAN
Tissue specificity: Found in all the cell types examined
genes like me logo Genes that share expression patterns with COIL: view

Protein tissue co-expression partners for COIL Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for COIL Gene

This gene was present in the common ancestor of chordates.

Orthologs for COIL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COIL 35
  • 82.48 (n)
  • 75.84 (a)
COIL 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COIL 35
  • 82.96 (n)
  • 75.3 (a)
COIL 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coil 35
  • 74.69 (n)
  • 66.96 (a)
Coil 16
Coil 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COIL 35
  • 99.36 (n)
  • 99.13 (a)
COIL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coil 35
  • 75.01 (n)
  • 66.14 (a)
oppossum
(Monodelphis domestica)
Mammalia COIL 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COIL 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves COIL 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COIL 36
  • 38 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397940 35
zebrafish
(Danio rerio)
Actinopterygii coil 35
coil 36
  • 37 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7255 35
Species with no ortholog for COIL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COIL Gene

ENSEMBL:
Gene Tree for COIL (if available)
TreeFam:
Gene Tree for COIL (if available)

Paralogs for COIL Gene

Pseudogenes.org Pseudogenes for COIL Gene

genes like me logo Genes that share paralogs with COIL: view

No data available for Paralogs for COIL Gene

Variants for COIL Gene

Sequence variations from dbSNP and Humsavar for COIL Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8599 -- 56,938,497(-) TCAGG(G/T)CCCTG utr-variant-3-prime
rs1042237 -- 56,938,861(-) TAATT(A/T)CAGTT utr-variant-3-prime
rs1042238 -- 56,938,799(-) GGTTT(A/C)TTCTC utr-variant-3-prime
rs1042239 -- 56,938,796(-) TTCTT(A/C)TCTTT utr-variant-3-prime
rs1042240 -- 56,938,782(-) TAAAT(C/G)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for COIL Gene

Variant ID Type Subtype PubMed ID
esv32884 CNV Loss 17666407

Variation tolerance for COIL Gene

Residual Variation Intolerance Score: 44.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 69.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COIL Gene

HapMap Linkage Disequilibrium report
COIL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COIL Gene

Disorders for COIL Gene

MalaCards: The human disease database

(2) MalaCards diseases for COIL Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
ischemic neuropathy
  • ischemic peripheral neuropathy
spinal muscular atrophy
  • werdnig-hoffmann disease
- elite association
Search COIL in MalaCards View complete list of genes associated with diseases

Relevant External Links for COIL

Genetic Association Database (GAD)
COIL
Human Genome Epidemiology (HuGE) Navigator
COIL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COIL
genes like me logo Genes that share disorders with COIL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COIL Gene

Publications for COIL Gene

  1. Structure, expression and chromosomal localization of human p80- coilin gene. (PMID: 7971277) Chan E.K.L. … Matera A.G. (Nucleic Acids Res. 1994) 2 23 67
  2. Coilin phosphorylation mediates interaction with SMN and SmB'. (PMID: 19997741) Toyota C.G. … Hebert M.D. (Chromosoma 2010) 23 67
  3. Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. (PMID: 20357773) Strzelecka M. … Neugebauer K.M. (Nat. Struct. Mol. Biol. 2010) 23 67
  4. The role of Cajal bodies in the expression of late phase adenovirus proteins. (PMID: 20137801) James N.J. … Blair G.E. (Virology 2010) 23 67
  5. Dynamic localization of tripartite motif-containing 22 in nuclear and nucleolar bodies. (PMID: 19331816) Sivaramakrishnan G. … Lin V.C. (Exp. Cell Res. 2009) 23 67

Products for COIL Gene

Sources for COIL Gene

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