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COIL Gene

protein-coding   GIFtS: 55
GCID: GC17M055015

Coilin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
coilin1 2
CLN802 3 5
p802 3
Coilin P802
p80-coilin2

External Ids:    HGNC: 21841   Entrez Gene: 81612   Ensembl: ENSG000001210587   OMIM: 6002725   UniProtKB: P384323   

Export aliases for COIL gene to outside databases

Previous GC identifers: GC17M054752 GC17M057497 GC17M055357 GC17M055490 GC17M052370 GC17M050376


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COIL Gene:
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal
bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional
modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its
self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell.
Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies
and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
(provided by RefSeq, Jul 2008)

GeneCards Summary for COIL Gene:
COIL (coilin) is a protein-coding gene. Diseases associated with COIL include ischemic neuropathy, and differentiating neuroblastoma. GO annotations related to this gene include disulfide oxidoreductase activity and identical protein binding.

UniProtKB/Swiss-Prot: COIL_HUMAN, P38432
Function: Is a component of the nuclear coiled bodies (CBS) which are involved in the function or
assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific
phosphorylation of p80 coilin

Gene Wiki entry for COIL (Coilin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the COIL gene promoter:
         SRF   TBP   AP-1   SRF (504 AA)   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOIL promoter sequence
   Search Chromatin IP Primers for COIL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COIL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

COIL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COIL gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M055015:  view genomic region     (about GC identifiers)

Start:
55,015,548 bp from pter      End:
55,038,415 bp from pter
Size:
22,868 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: COIL_HUMAN, P38432 (See protein sequence)
Recommended Name: Coilin  
Size: 576 amino acids; 62608 Da
Subunit: Interacts with ANKS1B
Secondary accessions: B2R931

Explore the universe of human proteins at neXtProt for COIL: NX_P38432

Explore proteomics data for COIL at MOPED

Post-translational modifications: 

  • Symmetrical dimethylation of arginine residues within the RG repeat region modulates affinity for SMN, and thus,
    localization of SMN complexes to the nuclear coiled bodies1
  • Ubiquitination2 at Lys555
  • Modification sites at PhosphoSitePlus

  • See COIL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004636.1  
    ENSEMBL proteins: 
     ENSP00000240316   ENSP00000460217  

    COIL Human Recombinant Protein Products:

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    Novus Biologicals COIL Protein
    Novus Biologicals COIL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for COIL

    COIL Antibody Products:

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    COIL Assay Products:

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    Cloud-Clone Corp. CLIAs for COIL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024822 Coilin

    Graphical View of Domain Structure for InterPro Entry P38432

    ProtoNet protein and cluster: P38432

    UniProtKB/Swiss-Prot: COIL_HUMAN, P38432
    Domain: The atypical Tudor domain at the C-terminus contains two large unstructured loops, and doesn't bind
    methylated residues
    Similarity: Belongs to the coilin family
    Similarity: Contains 1 Tudor domain


    COIL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COIL_HUMAN, P38432
    Function: Is a component of the nuclear coiled bodies (CBS) which are involved in the function or
    assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific
    phosphorylation of p80 coilin

         Genatlas biochemistry entry for COIL:
    coilin,protein of the non-capsular nuclear bodies (coiled bodies),in interphase cells,80kDa

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12757932
    GO:0008022protein C-terminus binding IPI12757932
    GO:0015036disulfide oxidoreductase activity IEA--
    GO:0042802identical protein binding IPI16713569
         
    COIL for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Coil):
     cellular  mortality/aging 

    COIL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Coiltm1Agm for COIL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COIL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COIL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COIL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COIL

    miRNA
    Products:
        
    miRTarBase miRNAs that target COIL:
    hsa-mir-98-5p (MIRT027424), hsa-mir-1 (MIRT001376), hsa-let-7b-5p (MIRT001578), hsa-mir-1229-3p (MIRT036262), hsa-mir-222-3p (MIRT046608), hsa-mir-1285-3p (MIRT035906), hsa-mir-15b-5p (MIRT046486), hsa-mir-125a-5p (MIRT045705)

    Block miRNA regulation of human, mouse, rat COIL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COIL (see all 21):
    hsa-let-7d hsa-miR-202 hsa-miR-488 hsa-let-7c hsa-miR-500a hsa-let-7g hsa-let-7a hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidCOIL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COIL
    Predesigned siRNA for gene silencing in human, mouse, rat COIL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COIL

    Clone
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    OriGene clones in human, mouse for COIL (see all 7)
    OriGene ORF clones in mouse, rat for COIL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COIL (NM_004645)
    Sino Biological Human cDNA Clone for COIL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COIL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COIL

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for COIL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COIL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COIL_HUMAN, P38432: Nucleus. Note=Nuclear coiled body located in the interchromatin space between the nucleolus
    and the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001674female germ cell nucleus IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA12757932
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    COIL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COIL
    Interactions:

        GeneGlobe Interaction Network for COIL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COIL (P384321, 2, 3 ENSP000002403164) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC5P130101, 2, 3EBI-945751,EBI-357997 MINT-8052957 MINT-8052894 MINT-8052908 MINT-8052786 MINT-8052765 MINT-8052804 I2D: score=1 
    CEP70Q8NHQ11, 2, 3, ENSP000002649824EBI-945751,EBI-739624 MINT-2876726 MINT-2876707 I2D: score=3 STRING: ENSP00000264982
    LNX1Q8TBB11, 2, 3, ENSP000002639254EBI-945751,EBI-739832 MINT-2877433 MINT-2855463 I2D: score=3 STRING: ENSP00000263925
    DHX16O602312, 3, ENSP000003656254MINT-2865160 I2D: score=3 STRING: ENSP00000365625
    ENSG00000206406P678702, 3MINT-2857838 I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COIL

    8 Novoseek inferred chemical compound relationships for COIL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actinomycin d 39.7 3 8612682 (2), 10751146 (1)
    okadaic acid 19.6 1 9013710 (1)
    rrna 12.7 2 9112227 (1)
    arginine 6.85 1 12486110 (1)
    aspartate 4.85 3 9013710 (1), 9743589 (1)
    cycloheximide 3.2 1 10512877 (1)
    pyruvate 0 3 10512877 (1), 9699418 (1)
    serine 0 3 9013710 (1), 9743589 (1)



    COIL for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COIL gene: 
    NM_004645.2  

    Unigene Cluster for COIL:

    Coilin
    Hs.532795  [show with all ESTs]
    Unigene Representative Sequence: BC010385
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240316(uc002iuu.3) ENST00000573008
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COIL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COIL (see all 21):
    hsa-let-7d hsa-miR-202 hsa-miR-488 hsa-let-7c hsa-miR-500a hsa-let-7g hsa-let-7a hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidCOIL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COIL
    Predesigned siRNA for gene silencing in human, mouse, rat COIL
    Clone
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    OriGene ORF clones in mouse, rat for COIL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COIL (NM_004645)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COIL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COIL
    Primer
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    OriGene qPCR primer pairs and template standards for COIL
    OriGene qSTAR qPCR primer pairs in human, mouse for COIL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COIL
      QuantiTect SYBR Green Assays in human, mouse, rat COIL
      QuantiFast Probe-based Assays in human, mouse, rat COIL

    Additional mRNA sequence: 

    AK313616.1 BC010385.1 M58411.1 U06632.1 

    9 DOTS entries:

    DT.117156  DT.100692058  DT.100714986  DT.100769597  DT.100806895  DT.100806898  DT.100806899  DT.40106002 
    DT.120950534 

    Selected AceView cDNA sequences (see all 175):

    AL041190 BQ001448 BF055988 BM978288 AA977067 R26308 AI825820 BM799937 
    BF222423 BF939452 CR605137 CB853192 AI216471 AW949393 BX379049 CR611341 
    AI344290 AW134642 BU618421 AA128900 BF445836 N58051 AW292795 BC010385 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COIL expression in normal human tissues (normalized intensities)      COIL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTTGACC
    COIL Expression
    About this image


    COIL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Neural Tube (Nervous System)
             Spinal Dorsal Columns
     
     Skeletal Muscle (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Testis (Reproductive System)
    COIL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COIL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532795

    UniProtKB/Swiss-Prot: COIL_HUMAN, P38432
    Tissue specificity: Found in all the cell types examined

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    QuantiFast Probe-based Assays in human, mouse, rat COIL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COIL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for COIL gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coil1 , 5 coilin1, 5 74.69(n)1
    66.96(a)1
      11 (54.34 cM)5
    128121  NM_016706.21  NP_057915.21 
     889702525 
    chicken
    (Gallus gallus)
    Aves COIL6
    coilin
    36(a)
    1 ↔ 1
    18(6262355-6267812)
    lizard
    (Anolis carolinensis)
    Reptilia COIL6
    coilin
    38(a)
    1 ↔ 1
    GL343198.1(683283-691699)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979402 sphere organelle protein sph-1 76.41(n)    Z23011.1 
    zebrafish
    (Danio rerio)
    Actinopterygii coil2 coilin p80 73.83(n)   58024  BC045858.1 


    ENSEMBL Gene Tree for COIL (if available)
    TreeFam Gene Tree for COIL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COIL gene

    COIL for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for COIL
    PGOHUM00000247779 PGOHUM00000246064


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COIL (see all 563)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924528711,2
    --55015151(+) AACTGA/GTAATA 1 -- ds50010--------
    rs1154087891,2
    F--55015160(+) TAATCT/CGAGAA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs728423281,2
    C,F--55015218(+) TATCTT/CAATTT 1 -- ds50013Minor allele frequency- C:0.02WA NA EA 358
    rs1840778971,2
    --55015358(+) ACATTA/CATGTC 1 -- ds50010--------
    rs1396598361,2
    --55015378(+) AAAACC/TGGCCA 1 -- ds50010--------
    rs1444243931,2
    C--55015641(+) TTTCAC/TGGTAT 1 -- ut310--------
    rs1510976371,2
    C--55015810(+) CTCCAC/GGCATA 1 -- ut310--------
    rs1881815981,2
    --55015838(+) CTTATC/TTTCAC 1 -- ut310--------
    rs85991,2
    C,F--55015858(-) TCAGGT/GCCCTG 1 -- ut31 ese35Minor allele frequency- G:0.01MN NA WA CSA 191
    rs1931736871,2
    --55015875(+) TTAATC/TTTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for COIL (55015548 - 55038415 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for COIL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv32884CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COIL
    DNA2.0 Custom Variant and Variant Library Synthesis for COIL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600272    OMIM disorders: --

    17 diseases for COIL:    About MalaCards
    ischemic neuropathy    differentiating neuroblastoma    muscular atrophy    spinal muscular atrophy
    rheumatic disease    vaccinia    primary biliary cirrhosis    neuroblastoma
    lupus erythematosus    atopic dermatitis    dermatitis    neuropathy
    influenza    systemic lupus erythematosus    ataxia    leukemia
    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for COIL:
    Muscular atrophy     Ischemic neuropathy     Spinal muscular atrophy

    COIL for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for COIL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular atrophy spinal 76.4 1 11641277 (1)
    sclerosis systemic 24.8 1 7604300 (1)
    leukemia 6.41 1 15955076 (1)
    lupus erythematosus systemic 4.87 1 7604300 (1)

    Genetic Association Database (GAD): COIL
    Human Genome Epidemiology (HuGE) Navigator: COIL (15 documents)

    Export disorders for COIL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COIL gene, integrated from 10 sources (see all 161):
    (articles sorted by number of sources associating them with COIL)
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    1. Structure, expression and chromosomal localization of human p80- coilin gene. (PubMed id 7971277)1, 2, 3, 9 Chan E.K.L.... Matera A.G. (Nucleic Acids Res. 1994)
    2. Coilin methylation regulates nuclear body formation. (PubMed id 12361597)1, 2, 9 Hebert M.D.... Matera A.G. (Dev. Cell 2002)
    3. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. (PubMed id 2033369)1, 2, 9 Andrade L.E.C....Tan E.M. (J. Exp. Med. 1991)
    4. Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis -- evidence that the coiled body is a kinetic nuclear structure. (PubMed id 7679389)1, 2, 9 Carmo-Fonseca M.... Lamond A.I. (J. Cell Biol. 1993)
    5. Solution structure of the carboxy-terminal Tudor domain from human Coilin. (PubMed id 20875822)1, 2 Shanbhag R.... Donaldson L.W. (FEBS Lett. 2010)
    6. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    7. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. (PubMed id 15862129)1, 2 Xu H. and Hebert M.D. (BMC Cell Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8161 HGNC: 2184 AceView: COIL Ensembl:ENSG00000121058 euGenes: HUgn8161
    ECgene: COIL H-InvDB: COIL

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COIL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COIL gene:
    Search GeneIP for patents involving COIL

    GeneCards and IP:
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