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Aliases for COIL Gene

Aliases for COIL Gene

  • Coilin 2 3
  • CLN80 3 4 6
  • P80-Coilin 3 4
  • Coilin P80 3
  • P80 3

External Ids for COIL Gene

Previous GeneCards Identifiers for COIL Gene

  • GC17M054752
  • GC17M057497
  • GC17M055357
  • GC17M055490
  • GC17M052370
  • GC17M055015
  • GC17M050376

Summaries for COIL Gene

Entrez Gene Summary for COIL Gene

  • The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

GeneCards Summary for COIL Gene

COIL (Coilin) is a Protein Coding gene. Diseases associated with COIL include ischemic neuropathy and differentiating neuroblastoma. GO annotations related to this gene include identical protein binding and disulfide oxidoreductase activity.

UniProtKB/Swiss-Prot for COIL Gene

  • Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.

Gene Wiki entry for COIL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COIL Gene

Genomics for COIL Gene

Regulatory Elements for COIL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COIL Gene

56,938,187 bp from pter
56,961,054 bp from pter
22,868 bases
Minus strand

Genomic View for COIL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COIL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COIL Gene

Proteins for COIL Gene

  • Protein details for COIL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R931

    Protein attributes for COIL Gene

    576 amino acids
    Molecular mass:
    62608 Da
    Quaternary structure:
    • Interacts with ANKS1B. Interacts with SMN (via Tudor domain). Interacts (via C-terminus) with AK6.

neXtProt entry for COIL Gene

Proteomics data for COIL Gene at MOPED

Post-translational modifications for COIL Gene

  • Phosphorylation during mitosis is associated with disassembly of CBs.
  • Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs
  • Ubiquitination at Lys555
  • Modification sites at PhosphoSitePlus

Other Protein References for COIL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for COIL (coilin)

No data available for DME Specific Peptides for COIL Gene

Domains for COIL Gene

Protein Domains for COIL Gene


Suggested Antigen Peptide Sequences for COIL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P38432
  • The atypical Tudor domain at the C-terminus contains two large unstructured loops, and does not bind methylated residues.
  • Contains 1 Tudor domain.
  • Belongs to the coilin family.
genes like me logo Genes that share domains with COIL: view

No data available for Gene Families for COIL Gene

Function for COIL Gene

Molecular function for COIL Gene

GENATLAS Biochemistry:
coilin,protein of the non-capsular nuclear bodies (coiled bodies),in interphase cells,80kDa
UniProtKB/Swiss-Prot Function:
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.

Gene Ontology (GO) - Molecular Function for COIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12757932
GO:0008022 protein C-terminus binding IPI 12757932
GO:0042802 identical protein binding IPI 16713569
genes like me logo Genes that share ontologies with COIL: view

Phenotypes for COIL Gene

genes like me logo Genes that share phenotypes with COIL: view

Animal Models for COIL Gene

MGI Knock Outs for COIL:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for COIL Gene

Localization for COIL Gene

Subcellular locations from UniProtKB/Swiss-Prot for COIL Gene

Nucleus. Nucleus, Cajal body.

Subcellular locations from

Jensen Localization Image for COIL Gene COMPARTMENTS Subcellular localization image for COIL gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for COIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA 12757932
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0015030 Cajal body IDA 12757932
genes like me logo Genes that share ontologies with COIL: view

Compounds for COIL Gene

(8) Novoseek inferred chemical compound relationships for COIL Gene

Compound -log(P) Hits PubMed IDs
actinomycin d 39.7 3
okadaic acid 19.6 1
rrna 12.7 1
arginine 6.85 1
aspartate 4.85 2
genes like me logo Genes that share compounds with COIL: view

Transcripts for COIL Gene

mRNA/cDNA for COIL Gene

(175) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COIL Gene

Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COIL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COIL Gene

No ASD Table

Relevant External Links for COIL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COIL Gene

mRNA expression in normal human tissues for COIL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COIL Gene

This gene is overexpressed in Testis (6.0).

Protein differential expression in normal tissues for COIL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.3), Testis (12.3), Monocytes (10.1), and Breast (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COIL Gene

SOURCE GeneReport for Unigene cluster for COIL Gene Hs.532795

mRNA Expression by UniProt/SwissProt for COIL Gene

Tissue specificity: Found in all the cell types examined
genes like me logo Genes that share expressions with COIL: view

Expression partners for COIL Gene

In Situ Assay Products

Orthologs for COIL Gene

This gene was present in the common ancestor of chordates.

Orthologs for COIL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COIL 35
  • 82.48 (n)
  • 75.84 (a)
  • 75 (a)
(Canis familiaris)
Mammalia COIL 35
  • 82.96 (n)
  • 75.3 (a)
  • 75 (a)
(Mus musculus)
Mammalia Coil 35
  • 74.69 (n)
  • 66.96 (a)
Coil 16
Coil 36
  • 66 (a)
(Pan troglodytes)
Mammalia COIL 35
  • 99.36 (n)
  • 99.13 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Coil 35
  • 75.01 (n)
  • 66.14 (a)
(Monodelphis domestica)
Mammalia COIL 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia COIL 36
  • 56 (a)
(Gallus gallus)
Aves COIL 36
  • 36 (a)
(Anolis carolinensis)
Reptilia COIL 36
  • 38 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397940 35
(Danio rerio)
Actinopterygii coil 35
coil 36
  • 37 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7255 35
Species with no ortholog for COIL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COIL Gene

Gene Tree for COIL (if available)
Gene Tree for COIL (if available)

Paralogs for COIL Gene Pseudogenes for COIL Gene

genes like me logo Genes that share paralogs with COIL: view

No data available for Paralogs for COIL Gene

Variants for COIL Gene

Sequence variations from dbSNP and Humsavar for COIL Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8599 -- 56,938,497(-) TCAGG(G/T)CCCTG utr-variant-3-prime
rs1042237 -- 56,938,861(-) TAATT(A/T)CAGTT utr-variant-3-prime
rs1042238 -- 56,938,799(-) GGTTT(A/C)TTCTC utr-variant-3-prime
rs1042239 -- 56,938,796(-) TTCTT(A/C)TCTTT utr-variant-3-prime
rs1042240 -- 56,938,782(-) TAAAT(C/G)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for COIL Gene

Variant ID Type Subtype PubMed ID
esv32884 CNV Loss 17666407

Relevant External Links for COIL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COIL Gene

Disorders for COIL Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for COIL Gene in MalaCards »

(3) Diseases for COIL Gene including...

(3) University of Copenhagen DISEASES for COIL Gene

(4) Novoseek inferred disease relationships for COIL Gene

Disease -log(P) Hits PubMed IDs
muscular atrophy spinal 76.4 1
sclerosis systemic 24.8 1
leukemia 6.41 1
lupus erythematosus systemic 4.87 1

Relevant External Links for COIL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with COIL: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for COIL Gene

Publications for COIL Gene

  1. Structure, expression and chromosomal localization of human p80- coilin gene. (PMID: 7971277) Chan E.K.L. … Matera A.G. (Nucleic Acids Res. 1994) 2 3 4 23
  2. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. (PMID: 2033369) Andrade L.E.C. … Tan E.M. (J. Exp. Med. 1991) 3 4 23
  3. Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis -- evidence that the coiled body is a kinetic nuclear structure. (PMID: 7679389) Carmo-Fonseca M. … Lamond A.I. (J. Cell Biol. 1993) 3 4 23
  4. Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein. (PMID: 11641277) Hebert M.D. … Matera A.G. (Genes Dev. 2001) 3 4 23
  5. Coilin methylation regulates nuclear body formation. (PMID: 12361597) Hebert M.D. … Matera A.G. (Dev. Cell 2002) 3 4 23

Products for COIL Gene

  • Addgene plasmids for COIL

Sources for COIL Gene

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