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Aliases for COG8 Gene

Aliases for COG8 Gene

  • Component Of Oligomeric Golgi Complex 8 2 3 4
  • COG Complex Subunit 8 3 4
  • CDG2H 3 6
  • DOR1 3 6
  • Conserved Oligomeric Golgi Complex Component 8 3
  • Conserved Oligomeric Golgi Complex Subunit 8 3
  • Dependent On RIC1 3

External Ids for COG8 Gene

Previous GeneCards Identifiers for COG8 Gene

  • GC16U990224
  • GC16M069741
  • GC16M069092
  • GC16M069139
  • GC16M069140
  • GC16M067921
  • GC16M069361
  • GC16M069354

Summaries for COG8 Gene

Entrez Gene Summary for COG8 Gene

  • This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq, Jul 2008]

GeneCards Summary for COG8 Gene

COG8 (Component Of Oligomeric Golgi Complex 8) is a Protein Coding gene. Diseases associated with COG8 include congenital disorder of glycosylation, type iih. An important paralog of this gene is ENSG00000272617.

UniProtKB/Swiss-Prot for COG8 Gene

  • Required for normal Golgi function.

Gene Wiki entry for COG8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COG8 Gene

Genomics for COG8 Gene

Regulatory Elements for COG8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COG8 Gene

69,320,140 bp from pter
69,339,667 bp from pter
19,528 bases
Minus strand

Genomic View for COG8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COG8 Gene

Proteins for COG8 Gene

  • Protein details for COG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Conserved oligomeric Golgi complex subunit 8
    Protein Accession:
    Secondary Accessions:
    • Q0VAK2
    • Q8WVV6
    • Q9H6F8

    Protein attributes for COG8 Gene

    612 amino acids
    Molecular mass:
    68424 Da
    Quaternary structure:
    • Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization
    • Sequence=AAH17492.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15301.1; Type=Frameshift; Positions=371; Evidence={ECO:0000305};

neXtProt entry for COG8 Gene

Proteomics data for COG8 Gene at MOPED

Post-translational modifications for COG8 Gene

  • Ubiquitination at Lys88 and Lys558
  • Modification sites at PhosphoSitePlus

Other Protein References for COG8 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for COG8

No data available for DME Specific Peptides for COG8 Gene

Domains for COG8 Gene

Gene Families for COG8 Gene

  • COG :Components of oligomeric golgi complex

Protein Domains for COG8 Gene

Suggested Antigen Peptide Sequences for COG8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96MW5
  • Belongs to the COG8 family.
genes like me logo Genes that share domains with COG8: view

Function for COG8 Gene

Molecular function for COG8 Gene

UniProtKB/Swiss-Prot Function:
Required for normal Golgi function.

Gene Ontology (GO) - Molecular Function for COG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COG8: view

Phenotypes for COG8 Gene

GenomeRNAi human phenotypes for COG8:
genes like me logo Genes that share phenotypes with COG8: view

Animal Model Products

miRNA for COG8 Gene

miRTarBase miRNAs that target COG8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COG8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COG8 Gene

Localization for COG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COG8 Gene

Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for COG8 Gene COMPARTMENTS Subcellular localization image for COG8 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 4
chloroplast 2
cytosol 2
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0017119 Golgi transport complex NAS 11703943
genes like me logo Genes that share ontologies with COG8: view

Pathways for COG8 Gene

SuperPathways for COG8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with COG8: view

No data available for Pathways by source for COG8 Gene

Transcripts for COG8 Gene

Unigene Clusters for COG8 Gene

Component of oligomeric golgi complex 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COG8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COG8 Gene

No ASD Table

Relevant External Links for COG8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COG8 Gene

mRNA expression in normal human tissues for COG8 Gene

Protein differential expression in normal tissues for COG8 Gene

This gene is overexpressed in Bone (62.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for COG8 Gene

SOURCE GeneReport for Unigene cluster for COG8 Gene Hs.130849

genes like me logo Genes that share expressions with COG8: view

Expression partners for COG8 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COG8 Gene

Orthologs for COG8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COG8 35
  • 87.42 (n)
  • 88.47 (a)
(Canis familiaris)
Mammalia COG8 35
  • 89.58 (n)
  • 90.97 (a)
(Mus musculus)
Mammalia Cog8 35
  • 85.23 (n)
  • 89.46 (a)
Cog8 16
Cog8 36
  • 84 (a)
(Pan troglodytes)
Mammalia COG8 35
  • 99.49 (n)
  • 99.81 (a)
COG8 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cog8 35
  • 85.62 (n)
  • 89.92 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
(Gallus gallus)
Aves COG8 35
  • 73.35 (n)
  • 74.72 (a)
-- 36
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cog8 35
  • 68.5 (n)
  • 75.92 (a)
(Danio rerio)
Actinopterygii cog8 35
  • 70.83 (n)
  • 74.67 (a)
cog8 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6488 37
  • 44 (a)
CG6488 35
  • 53.91 (n)
  • 45.97 (a)
CG6488 36
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011488 35
  • 52.63 (n)
  • 47.31 (a)
(Caenorhabditis elegans)
Secernentea R02D3.2 37
  • 23 (a)
cogc-8 35
  • 40.47 (n)
  • 26.8 (a)
cogc-8 36
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COG8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G11980 35
  • 47.25 (n)
  • 37.39 (a)
(Oryza sativa)
Liliopsida Os12g0538300 35
  • 46.91 (n)
  • 35.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for COG8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COG8 Gene

Gene Tree for COG8 (if available)
Gene Tree for COG8 (if available)

Paralogs for COG8 Gene

Paralogs for COG8 Gene

genes like me logo Genes that share paralogs with COG8: view

Variants for COG8 Gene

Sequence variations from dbSNP and Humsavar for COG8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3027 - 69,332,746(+) GAAAA(A/C)GGACT missense, reference
rs715162 -- 69,336,355(-) TTATT(C/T)AAAAT intron-variant
rs877534 -- 69,334,093(+) ACTTG(A/C)ATGAG intron-variant
rs1142625 -- 69,334,535(-) TGGAA(A/G)ATGCC missense, reference
rs1142626 -- 69,334,498(-) GTTTT(C/T)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COG8 Gene

Variant ID Type Subtype PubMed ID
nsv906820 CNV Loss 21882294
nsv827715 CNV Loss 20364138

Relevant External Links for COG8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COG8 Gene

Disorders for COG8 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for COG8 Gene in MalaCards »

(1) Diseases for COG8 Gene including...

(1) OMIM Diseases for COG8 Gene (606979)


  • Congenital disorder of glycosylation 2H (CDG2H) [MIM:611182]: CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:17331980}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for COG8 Gene

Relevant External Links for COG8

genes like me logo Genes that share disorders with COG8: view

No data available for Novoseek inferred disease relationships and Genatlas for COG8 Gene

Publications for COG8 Gene

  1. The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. (PMID: 11703943) Whyte J.R. … Munro S. (Dev. Cell 2001) 3 4
  2. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PMID: 11980916) Ungar D. … Waters M.G. (J. Cell Biol. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. COG8 deficiency causes new congenital disorder of glycosylation type IIh. (PMID: 17331980) Kranz C. … Freeze H.H. (Hum. Mol. Genet. 2007) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for COG8 Gene

Sources for COG8 Gene

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