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COG8 Gene

protein-coding   GIFtS: 53
GCID: GC16M069354

Component Of Oligomeric Golgi Complex 8

  See COG8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Component Of Oligomeric Golgi Complex 81 2 3     Conserved Oligomeric Golgi Complex Component 82
COG Complex Subunit 82 3     Conserved Oligomeric Golgi Complex Subunit 82
CDG2H2 5     Dependent On RIC12
DOR12 5     

External Ids:    HGNC: 186231   Entrez Gene: 843422   Ensembl: ENSG000002133807   OMIM: 6069795   UniProtKB: Q96MW53   

Export aliases for COG8 gene to outside databases

Previous GC identifers: GC16U990224 GC16M069741 GC16M069092 GC16M069139 GC16M069140 GC16M067921 GC16M069361


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COG8 Gene:
This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein
complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane
trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation,
type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe
psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. (provided by
RefSeq, Jul 2008)

GeneCards Summary for COG8 Gene:
COG8 (component of oligomeric golgi complex 8) is a protein-coding gene. Diseases associated with COG8 include congenital disorder of glycosylation, type iih, and nephronophthisis-like nephropathy 1. An important paralog of this gene is ENSG00000260371.

UniProtKB/Swiss-Prot: COG8_HUMAN, Q96MW5
Function: Required for normal Golgi function (By similarity)

Gene Wiki entry for COG8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the COG8 gene promoter:
         AML1a   p53   Nkx2-2   CUTL1   LCR-F1   HEN1   CBF-A   CP1A   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): COG8 promoter sequence
   Search Chromatin IP Primers for COG8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COG8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

COG8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COG8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M069354:  view genomic region     (about GC identifiers)

Start:
69,354,043 bp from pter      End:
69,373,570 bp from pter
Size:
19,528 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COG8_HUMAN, Q96MW5 (See protein sequence)
Recommended Name: Conserved oligomeric Golgi complex subunit 8  
Size: 612 amino acids; 68424 Da
Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is
required for normal Golgi morphology and localization
Sequence caution: Sequence=AAH17492.1; Type=Erroneous initiation; Sequence=BAB15301.1; Type=Frameshift;
Positions=371;
Secondary accessions: Q0VAK2 Q8WVV6 Q9H6F8

Explore the universe of human proteins at neXtProt for COG8: NX_Q96MW5

Explore proteomics data for COG8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys88, Lys558
  • Modification sites at PhosphoSitePlus

  • See COG8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115758.3  
    ENSEMBL proteins: 
     ENSP00000456705   ENSP00000305459   ENSP00000455954   ENSP00000464395  

    COG8 Human Recombinant Protein Products:

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    Novus Biologicals COG8 Proteins
    Novus Biologicals COG8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COG8

     
    Search eBioscience for Proteins for COG8 

    COG8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    COG8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for COG8
    Cloud-Clone Corp. CLIAs for COG8
    Search eBioscience for ELISAs for COG8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COG: Components of oligomeric golgi complex

    3 InterPro protein domains:
     IPR016632 COG8_Metazoal_Plant
     IPR007255 COG8
     IPR016159 Cullin_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96MW5

    ProtoNet protein and cluster: Q96MW5

    1 Blocks protein domain: IPB007255 Dor1-like protein

    UniProtKB/Swiss-Prot: COG8_HUMAN, Q96MW5
    Similarity: Belongs to the COG8 family


    Find genes that share domains with COG8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COG8_HUMAN, Q96MW5
    Function: Required for normal Golgi function (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for COG8:

     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COG8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COG8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COG8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COG8

    miRNA
    Products:
        
    miRTarBase miRNAs that target COG8:
    hsa-mir-186-5p (MIRT045035)

    Block miRNA regulation of human, mouse, rat COG8 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate COG8
    SwitchGear 3'UTR luciferase reporter plasmidCOG8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COG8
    Predesigned siRNA for gene silencing in human, mouse, rat COG8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COG8

    Clone
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    OriGene clones in human, mouse for COG8 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: COG8 (NM_032382)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COG8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG8

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COG8_HUMAN, Q96MW5: Golgi apparatus membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    mitochondrion4
    chloroplast2
    cytosol2
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0017119Golgi transport complex NAS11703943

    Find genes that share ontologies with COG8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COG8
    Interactions:

        GeneGlobe Interaction Network for COG8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COG8 (Q96MW52, 3 ENSP000003054594) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COG3Q96JB22, 3, ENSP000002586544MINT-7296787 MINT-7296769 MINT-7296802 I2D: score=1 STRING: ENSP00000258654
    COG7P834362, ENSP000003054424MINT-7296787 MINT-7296769 MINT-7296802 STRING: ENSP00000305442
    SCFD1Q8WVM82, ENSP000003907834MINT-7296787 MINT-7296769 MINT-7296802 STRING: ENSP00000390783
    COG4Q9H9E32, ENSP000003157754MINT-7296787 MINT-7296769 MINT-7296802 STRING: ENSP00000315775
    COG1Q8WTW33, ENSP000002998864I2D: score=5 STRING: ENSP00000299886
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--

    Find genes that share ontologies with COG8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COG8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COG8 gene: 
    NM_032382.4  

    Unigene Cluster for COG8:

    Component of oligomeric golgi complex 8
    Hs.130849  [show with all ESTs]
    Unigene Representative Sequence: NM_032382
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564419 ENST00000562595 ENST00000306875(uc002ewy.2) ENST00000562081
    ENST00000567493
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COG8 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate COG8
    SwitchGear 3'UTR luciferase reporter plasmidCOG8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COG8
    Predesigned siRNA for gene silencing in human, mouse, rat COG8
    Clone
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    OriGene clones in human, mouse for COG8 (see all 7)
    OriGene ORF clones in mouse, rat for COG8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COG8 (NM_032382)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COG8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG8
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for COG8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COG8
      QuantiTect SYBR Green Assays in human, mouse, rat COG8
      QuantiFast Probe-based Assays in human, mouse, rat COG8

    Additional mRNA sequence: 

    AF239156.1 AF322879.1 AK025968.1 AK056344.1 AK225391.1 AK302605.1 BC017492.1 BC019912.1 
    BC063831.1 BC121022.1 BC121023.1 

    22 DOTS entries:

    DT.92438398  DT.99940751  DT.308282  DT.100649300  DT.40221796  DT.100794074  DT.120680976  DT.110283 
    DT.100794078  DT.120680962  DT.95313064  DT.100025157  DT.120681129  DT.204175  DT.95318488  DT.120680982 
    DT.91681427  DT.91763586  DT.97839393  DT.97839394  DT.100769230  DT.120681231 

    Selected AceView cDNA sequences (see all 266):

    BM052973 AI417191 AI990860 BX109144 AK056344 AL045195 CA432450 AI823498 
    BU154340 BC017492 CB163901 NM_022341 CB152385 CA503332 AA704547 AI160070 
    AI524240 AI085705 AA953598 AI991677 AI684882 CA771465 CR624165 CR606206 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COG8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTGGCAA
    COG8 Expression
    About this image

    COG8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COG8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.130849
        Custom PCR Arrays for COG8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COG8 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cog81 , 5 component of oligomeric golgi complex 81, 5 85.23(n)1
    89.46(a)1
      8 (53.55 cM)5
    974841  NM_139229.41  NP_631975.31 
     1070462895 
    chicken
    (Gallus gallus)
    Aves COG81 component of oligomeric golgi complex 8 73.35(n)
    74.72(a)
      769684  XM_001232974.3  XP_001232975.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    63(a)
    1 → many
    GL343643.1(38676-46203)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cog81 component of oligomeric golgi complex 8 68.5(n)
    75.92(a)
      100495068  XM_002937574.2  XP_002937620.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cog81 component of oligomeric golgi complex 8 70.83(n)
    74.67(a)
      541379  NM_001013506.1  NP_001013524.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64881 , 3 CG64881 44(a)3
    53.91(n)1
    45.97(a)1
      32F23
    345711  NM_135659.21  NP_609503.21 
    worm
    (Caenorhabditis elegans)
    Secernentea R02D3.23
    cogc-81
    cogc-81 23(a)3
    40.47(n)1
    26.8(a)1
      IV(240589-243904)3
    1768411  NM_067482.31  NP_499883.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G119801 AT5G11980 47.25(n)
    37.39(a)
      831071  NM_121236.1  NP_568256.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g05383001 Os12g0538300 46.91(n)
    35.13(a)
      4352423  NM_001073472.1  NP_001066940.1 


    ENSEMBL Gene Tree for COG8 (if available)
    TreeFam Gene Tree for COG8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COG8 gene
    ENSG000002603712  ENSG000002726172  

    Find genes that share paralogs with COG8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COG8 (see all 404)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136564151,2
    C,F--70368662(+) ACCTCG/ATGATC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1137222721,2
    C,F--70368738(+) TAAACC/TTACAC 1 -- ds50010--------
    rs1464190801,2
    --70368760(+) TGATAC/TTAATT 1 -- ds50010--------
    rs1876716431,2
    --70368878(+) CCAGCC/TCTGAT 1 -- ds50010--------
    rs1407576731,2
    --70368972(+) TGTGTA/GGGCAC 1 -- ds50010--------
    rs71861501,2
    C,F,H--70368985(+) ATTTAC/AACTCG 1 -- ds50018Minor allele frequency- A:0.06NS NA WA 1070
    rs22424131,2
    C,F,A,H--70369029(+) ATTCTC/GTTTCA 1 -- ds500115Minor allele frequency- G:0.18EA NS NA WA CSA 2280
    rs1438197891,2
    --70369118(+) CTTACA/CTGCAT 1 -- ut310--------
    rs1932076711,2
    --70369295(+) TTCTCC/TTCAAG 1 -- ut310--------
    rs10554011,2
    C,F,A,H--70369354(-) GAGGAA/TGATGT 1 -- ut316Minor allele frequency- T:0.07MN NA EA 430

    HapMap Linkage Disequilibrium report for COG8 (69354043 - 69373570 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for COG8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv827715CNV Loss20364138
    nsv906820CNV Loss21882294

    Human Gene Mutation Database (HGMD): COG8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COG8
    DNA2.0 Custom Variant and Variant Library Synthesis for COG8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606979   
    OMIM disorders: 611182  
    UniProtKB/Swiss-Prot: COG8_HUMAN, Q96MW5
  • Congenital disorder of glycosylation 2H (CDG2H) [MIM:611182]: CDGs are a family of severe inherited
    diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum
    proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the
    nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and
    immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic
    development, differentiation, and maintenance of cell functions. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 2 diseases for COG8:    
    About MalaCards
    congenital disorder of glycosylation, type iih    nephronophthisis-like nephropathy 1

    1 disease from the University of Copenhagen DISEASES database for COG8:
    Congenital disorder of glycosylation

    Find genes that share disorders with COG8           About GenesLikeMe

    GeneTests: COG8
    GeneReviews: COG8

    Export disorders for COG8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COG8 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with COG8)
        Utopia: connect your pdf to the dynamic
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    1. COG8 deficiency causes new congenital disorder of glycosylation type IIh. (PubMed id 17331980)1, 2 Kranz C.... Freeze H.H. (Hum. Mol. Genet. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PubMed id 11980916)1, 3 Ungar D.... Waters M.G. (J. Cell Biol. 2002)
    5. The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. (PubMed id 11703943)1, 2 Whyte J.R. and Munro S. (Dev. Cell 2001)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Successful COG8 and PDF overlap is mediated by alterations in splicing and polyadenylation signals. (PubMed id 21805148)1 Pereira-Castro I....Azevedo L. (Hum. Genet. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84342 HGNC: 18623 AceView: PDF Ensembl:ENSG00000213380 euGenes: HUgn84342
    ECgene: COG8 H-InvDB: COG8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COG8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for COG8 gene:
    Search GeneIP for patents involving COG8

    GeneCards and IP:
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