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COG7 Gene

protein-coding   GIFtS: 52
GCID: GC16M023307

Component Of Oligomeric Golgi Complex 7

  See COG7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Component Of Oligomeric Golgi Complex 71 2 3
COG Complex Subunit 72 3
CDG2E2 5
Conserved Oligomeric Golgi Complex Subunit 72

External Ids:    HGNC: 186221   Entrez Gene: 919492   Ensembl: ENSG000001684347   OMIM: 6069785   UniProtKB: P834363   

Export aliases for COG7 gene to outside databases

Previous GC identifers: GC16M022808 GC16M023487 GC16M023327 GC16M023366 GC16M021487


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COG7 Gene:
The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved
oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this
gene are associated with the congenital disorder of glycosylation type IIe.(provided by RefSeq, May 2010)

GeneCards Summary for COG7 Gene:
COG7 (component of oligomeric golgi complex 7) is a protein-coding gene. Diseases associated with COG7 include congenital disorder of glycosylation type 2e.

UniProtKB/Swiss-Prot: COG7_HUMAN, P83436
Function: Required for normal Golgi function (By similarity)

Gene Wiki entry for COG7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COG7 gene promoter:
         Egr-3   AhR   STAT5B   p53   AML1a   GCNF   Arnt   CREB   deltaCREB   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOG7 promoter sequence
   Search Chromatin IP Primers for COG7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COG7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.2

COG7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COG7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M023307:  view genomic region     (about GC identifiers)

Start:
23,399,814 bp from pter      End:
23,464,512 bp from pter
Size:
64,699 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COG7_HUMAN, P83436 (See protein sequence)
Recommended Name: Conserved oligomeric Golgi complex subunit 7  
Size: 770 amino acids; 86344 Da
Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is
required for normal Golgi morphology and localization
Sequence caution: Sequence=AAQ88995.1; Type=Erroneous initiation;
Secondary accessions: Q6UWU7

Explore the universe of human proteins at neXtProt for COG7: NX_P83436

Explore proteomics data for COG7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COG7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_705831.1  
    ENSEMBL proteins: 
     ENSP00000305442   ENSP00000459872   ENSP00000460151  

    COG7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for COG7

     
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    antibodies-online proteins for COG7 (4 products) 

     
    antibodies-online peptides for COG7

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    antibodies-online antibodies for COG7 (28 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COG: Components of oligomeric golgi complex

    1 InterPro protein domain:
     IPR019335 COG7

    Graphical View of Domain Structure for InterPro Entry P83436

    ProtoNet protein and cluster: P83436

    UniProtKB/Swiss-Prot: COG7_HUMAN, P83436
    Similarity: Belongs to the COG7 family


    Find genes that share domains with COG7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COG7_HUMAN, P83436
    Function: Required for normal Golgi function (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15047703
         
    Find genes that share ontologies with COG7           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Cog7 (no phenotypes)

    Find genes that share phenotypes with COG7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cog7tm1Lex for COG7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COG7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COG7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COG7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COG7

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate COG7:
    hsa-miR-27a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidCOG7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COG7
    Predesigned siRNA for gene silencing in human, mouse, rat COG7

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG7

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COG7_HUMAN, P83436: Golgi apparatus membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus IDA11980916
    GO:0017119Golgi transport complex IDA15047703

    Find genes that share ontologies with COG7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COG7
    Interactions:

        Search GeneGlobe Interaction Network for COG7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for COG7 (P834361, 2, 3 ENSP000003054424) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COG4Q9H9E31, 2, 3, ENSP000003157754EBI-389534,EBI-368382 MINT-7296787 MINT-7296769 MINT-7296817 MINT-7296802 I2D: score=3 STRING: ENSP00000315775
    SCFD1Q8WVM82, ENSP000003907834MINT-7296787 MINT-7296769 MINT-7296817 MINT-7296802 STRING: ENSP00000390783
    COG3Q96JB22, ENSP000002586544MINT-7296787 MINT-7296769 MINT-7296817 MINT-7296802 STRING: ENSP00000258654
    COG8Q96MW52, ENSP000003054594MINT-7296787 MINT-7296769 MINT-7296802 STRING: ENSP00000305459
    COG5Q9UP831, 3, ENSP000002971354EBI-389534,EBI-389502 I2D: score=3 STRING: ENSP00000297135
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IMP15107842
    GO:0006886intracellular protein transport IMP15107842
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER IMP16420527
    GO:0033365protein localization to organelle IMP16420527
    GO:0034067protein localization to Golgi apparatus IMP16510524

    Find genes that share ontologies with COG7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COG7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COG7 gene: 
    NM_153603.3  

    Unigene Cluster for COG7:

    Component of oligomeric golgi complex 7
    Hs.185807  [show with all ESTs]
    Unigene Representative Sequence: AK126661
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307149(uc002dlo.3) ENST00000566364 ENST00000561854 ENST00000569635
    ENST00000563164 ENST00000567821
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate COG7:
    hsa-miR-27a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidCOG7 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for COG7
    Predesigned siRNA for gene silencing in human, mouse, rat COG7
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COG7
      QuantiTect SYBR Green Assays in human, mouse, rat COG7
      QuantiFast Probe-based Assays in human, mouse, rat COG7

    Additional mRNA sequence: 

    AF070568.1 AK093989.1 AK126661.1 AK130714.1 AY358632.1 BC000549.2 BC037563.1 

    10 DOTS entries:

    DT.97794431  DT.448939  DT.99983615  DT.92005676  DT.95236516  DT.97782490  DT.91863922  DT.449616 
    DT.449618  DT.95197473 

    Selected AceView cDNA sequences (see all 149):

    AA775076 AL710863 BM701825 BC037563 BX362788 AL542757 BM821557 AW388114 
    F11876 AV746608 CA389470 BG538729 BM464032 BI050276 AF070568 BC000549 
    AA075965 BI770126 AA076126 BF589842 F12679 F10290 AA325831 AW515217 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COG7 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a ·
    SP1:                                                              -                                         -                                   -     -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                            -     -         
    SP4:                                                                                                                                                  -         
    SP5:              -                                                                                                                                             

    ExUns: 18b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for COG7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COG7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCAGGAG
    COG7 Expression
    About this image

    COG7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COG7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.185807
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COG7 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cog71 , 5 component of oligomeric golgi complex 71, 5 88.05(n)1
    92.47(a)1
      7 (65.09 cM)5
    2338241  NM_001033318.31  NP_001028490.21 
     1219228395 
    chicken
    (Gallus gallus)
    Aves COG71 component of oligomeric golgi complex 7 74.71(n)
    79.14(a)
      416578  NM_001277564.1  NP_001264493.1 
    lizard
    (Anolis carolinensis)
    Reptilia COG76
    component of oligomeric golgi complex 7
    78(a)
    1 ↔ 1
    AAWZ02036406(3371-27518)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.339702 Xenopus laevis transcribed sequences 76.17(n)    BJ052096.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cog71 component of oligomeric golgi complex 7 66.88(n)
    70.8(a)
      768247  NM_001077393.1  NP_001070861.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cog71 Cog7 43.76(n)
    30.72(a)
      43547  NM_143493.3  NP_651750.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EYE1 EYE 42.92(n)
    29.04(a)
      835217  NM_124522.3  NP_199956.1 


    ENSEMBL Gene Tree for COG7 (if available)
    TreeFam Gene Tree for COG7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COG7 (see all 1297)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346461441,2
    C--23405379(+) CTCAG-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs342192651,2
    C--23408237(+) TTTTC-/TTTTTT 1 -- int10--------
    rs343596021,2
    C--23410334(+) GCCAGC/-CCTGG 1 -- int11Minor allele frequency- -:0.00NA 2
    rs578012611,2
    C--23413667(+) TTTTT-/TGTATT 1 -- int11Minor allele frequency- T:0.00CSA 2
    rs351895661,2
    C--23419535(+) GGCAGG/TGGGCG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs351457571,2
    C--23419539(+) GGGGGC/AGAGTG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1851521,2
    C--23419591(-) ccgccC/Acactc 1 -- int11Minor allele frequency- A:0.50NA 2
    rs425341,2
    C--23419624(-) cccctG/Acctcc 1 -- int11Minor allele frequency- A:0.50NA 2
    rs423931,2
    C--23419675(-) actcgC/Tcccct 1 -- int11Minor allele frequency- T:0.50NA 2
    rs398161,2
    C,F--23419698(-) actcgC/Tcccct 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for COG7 (23399814 - 23464512 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for COG7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1768CNV Insertion18451855

    Human Gene Mutation Database (HGMD): COG7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COG7
    DNA2.0 Custom Variant and Variant Library Synthesis for COG7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606978   
    OMIM disorders: 608779  
    UniProtKB/Swiss-Prot: COG7_HUMAN, P83436
  • Congenital disorder of glycosylation 2E (CDG2E) [MIM:608779]: A multisystem disorder caused by a defect
    in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of
    glycosylation result in a wide variety of clinical features, such as defects in the nervous system development,
    psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad
    spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation,
    and maintenance of cell functions. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 1 disease for COG7:    
    About MalaCards
    congenital disorder of glycosylation type 2e

    2 diseases from the University of Copenhagen DISEASES database for COG7:
    Congenital disorder of glycosylation     Cutis laxa

    Find genes that share disorders with COG7           About GenesLikeMe

    GeneTests: COG7
    GeneReviews: COG7

    Export disorders for COG7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COG7 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with COG7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PubMed id 11980916)1, 2, 3 Ungar D.... Waters M.G. (J. Cell Biol. 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder. (PubMed id 15107842)1, 2 Wu X.... Freeze H.H. (Nat. Med. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia. (PubMed id 17356545)1, 9 Morava E....Wevers R.A. (Eur. J. Hum. Genet. 2007)
    6. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    10. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91949 HGNC: 18622 AceView: COG7 Ensembl:ENSG00000168434 euGenes: HUgn91949
    ECgene: COG7 H-InvDB: COG7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COG7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for COG7 gene:
    Search GeneIP for patents involving COG7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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