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COG6 Gene

protein-coding   GIFtS: 50
GCID: GC13P040229

Component Of Oligomeric Golgi Complex 6

  See COG6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Component Of Oligomeric Golgi Complex 61 2 3     KIAA11343 5
COG Complex Subunit 62 3     Complexed With Dor1p 22
CDG2L2 5     Conserved Oligomeric Golgi Complex Protein 62
COD22 5     Conserved Oligomeric Golgi Complex Subunit 62
SHNS2 5     

External Ids:    HGNC: 186211   Entrez Gene: 575112   Ensembl: ENSG000001331037   OMIM: 6069775   UniProtKB: Q9Y2V73   

Export aliases for COG6 gene to outside databases

Previous GC identifers: GC13P038216 GC13P034216 GC13P039166 GC13P038027 GC13P039127 GC13P021028


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COG6 Gene:
This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal
structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi
complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple
transcript variants.(provided by RefSeq, Feb 2009)

GeneCards Summary for COG6 Gene:
COG6 (component of oligomeric golgi complex 6) is a protein-coding gene. Diseases associated with COG6 include shaheen syndrome, and congenital disorder of glycosylation, type iih.

UniProtKB/Swiss-Prot: COG6_HUMAN, Q9Y2V7
Function: Required for normal Golgi function (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the COG6 gene promoter:
         HOXA9   HOXA9B   Pax-2   Pax-2a   Evi-1   Meis-1b   POU2F1   POU2F1a   TGIF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOG6 promoter sequence
   Search Chromatin IP Primers for COG6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COG6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11   Ensembl cytogenetic band:  13q14.11   HGNC cytogenetic band: 13q13.2

COG6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COG6 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P040229:  view genomic region     (about GC identifiers)

Start:
40,229,764 bp from pter      End:
40,365,802 bp from pter
Size:
136,039 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COG6_HUMAN, Q9Y2V7 (See protein sequence)
Recommended Name: Conserved oligomeric Golgi complex subunit 6  
Size: 657 amino acids; 73279 Da
Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is
required for normal Golgi morphology and localization (By similarity)
Sequence caution: Sequence=AAD29633.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q5T0U1 Q6AI19 Q86V49 Q9ULT5
Alternative splicing: 3 isoforms:  Q9Y2V7-1   Q9Y2V7-2   Q9Y2V7-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for COG6: NX_Q9Y2V7

Explore proteomics data for COG6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COG6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138551.1  NP_065802.1  

    ENSEMBL proteins: 
     ENSP00000403733   ENSP00000441297   ENSP00000440438   ENSP00000440473   ENSP00000412877  
     ENSP00000397441   ENSP00000348983   ENSP00000445217  

    COG6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for COG6

     
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    antibodies-online proteins for COG6 (3 products) 

     
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    antibodies-online antibodies for COG6 (13 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COG: Components of oligomeric golgi complex

    1 InterPro protein domain:
     IPR010490 COG6

    Graphical View of Domain Structure for InterPro Entry Q9Y2V7

    ProtoNet protein and cluster: Q9Y2V7

    1 Blocks protein domain: IPB010490 Conserved oligomeric complex COG6

    UniProtKB/Swiss-Prot: COG6_HUMAN, Q9Y2V7
    Similarity: Belongs to the COG6 family


    Find genes that share domains with COG6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COG6_HUMAN, Q9Y2V7
    Function: Required for normal Golgi function (By similarity)

    Animal Models:

       genOway: Develop your customized and physiologically relevant rodent model for COG6

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate COG6 (see all 9):
    hsa-miR-3200-5p hsa-miR-2909 hsa-miR-548aa hsa-miR-659 hsa-miR-9 hsa-miR-550b hsa-miR-889 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidCOG6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat COG6

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COG6_HUMAN, Q9Y2V7: Golgi apparatus membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol2
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0017119Golgi transport complex IDA15047703

    Find genes that share ontologies with COG6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COG6
    Interactions:

        GeneGlobe Interaction Network for COG6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COG6 (Q9Y2V73 ENSP000003974414) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COG3Q96JB23, ENSP000002586544I2D: score=1 STRING: ENSP00000258654
    COG8Q96MW53, ENSP000003054594I2D: score=1 STRING: ENSP00000305459
    EXOC3O606453I2D: score=4 
    COPS7BQ9H9Q23I2D: score=3 
    NDC1Q9BTX13I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006891intra-Golgi vesicle-mediated transport IEA--
    GO:0015031protein transport IEA--
    GO:0070085glycosylation IMP--

    Find genes that share ontologies with COG6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COG6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COG6 gene (2 alternative transcripts): 
    NM_001145079.1  NM_020751.2  

    Unigene Cluster for COG6:

    Component of oligomeric golgi complex 6
    Hs.507805  [show with all ESTs]
    Unigene Representative Sequence: NM_001145079
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416691(uc010acb.2) ENST00000542266 ENST00000543790 ENST00000543804
    ENST00000422759 ENST00000455146(uc001uxh.2) ENST00000356576(uc001uxi.2)
    ENST00000536488 ENST00000537156 ENST00000465775 ENST00000460701
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COG6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COG6 (see all 9):
    hsa-miR-3200-5p hsa-miR-2909 hsa-miR-548aa hsa-miR-659 hsa-miR-9 hsa-miR-550b hsa-miR-889 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidCOG6 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat COG6
      QuantiFast Probe-based Assays in human, mouse, rat COG6

    Additional mRNA sequence: 

    AB032960.1 AF116827.1 AK026638.1 AK294443.1 AK310953.1 BC027469.1 BC051723.1 CR627406.1 
    NR_026745.1 

    8 DOTS entries:

    DT.95271521  DT.214834  DT.100784954  DT.95271518  DT.120782359  DT.75169227  DT.91721653  DT.95094696 

    22 AceView cDNA sequences:

    BU160952 CD109872 BQ880684 AL599284 BI457596 CB989039 BM477584 AW500299 
    BI463631 BX503552 BI547815 AL549064 BQ068185 AA358192 AV694533 AI525848 
    BC051723 AB032960 NM_020751 AF116827 CR627406 AK026638 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for COG6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                                  -                                                                                                         
    SP2:                    -                             -                                                                                                         
    SP3:                    -                             -                                                                                               -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for COG6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COG6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTAACTGG
    COG6 Expression
    About this image


    COG6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
    COG6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COG6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507805
        Custom PCR Arrays for COG6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COG6 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cog61 , 5 component of oligomeric golgi complex 61, 5 85.44(n)1
    91.02(a)1
      3 (24.10 cM)5
    675421  NM_026225.31  NP_080501.21 
     529821235 
    chicken
    (Gallus gallus)
    Aves COG61 component of oligomeric golgi complex 6 80.6(n)
    89.12(a)
      418888  XM_417082.4  XP_417082.2 
    lizard
    (Anolis carolinensis)
    Reptilia COG66
    component of oligomeric golgi complex 6
    78(a)
    1 ↔ 1
    1(132332561-132365095)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686622 hypothetical protein MGC68662 78.66(n)    BC060478.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC051776.12   -- 74.98(n)   393290  BC051776.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG19681 , 3 CG19681 50(a)3
    50.77(n)1
    43.4(a)1
      45C33
    359531  NM_165673.31  NP_724783.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K07C11.93   -- 22(a)   V(8221060-8223802)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COG66
    Component of the conserved oligomeric Golgi comple...
    14(a)
    1 ↔ 1
    XIV(549468-551987) YNL041C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G317801 AT1G31780 46.31(n)
    38.92(a)
      840065  NM_102912.4  NP_174458.2 
    rice
    (Oryza sativa)
    Liliopsida Os.439182 Oryza sativa (japonica cultivar-group) Hypothetical more 78.53(n)    NM_187606.1 


    ENSEMBL Gene Tree for COG6 (if available)
    TreeFam Gene Tree for COG6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COG6 (see all 2584)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0682404
    Congenital disorder of glycosylation 2L (CDG2L)4--see VAR_0682402 G V mis40--------
    rs676490711,2
    C--21027035(+) ACTAG-/TTTTCG 3 -- us2k10--------
    rs95488641,2
    C,F,H--21028114(+) GTTACT/ATTTTT 3 -- us2k114Minor allele frequency- A:0.01NS EA NA WA CSA 514
    rs95768821,2
    C,F,A,H--21028117(+) ACATTT/CTTATC 3 -- us2k119Minor allele frequency- C:0.48NS EA NA WA CSA 2343
    rs354390761,2
    C--21030647(+) TTTTTT/-CTGTA 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs2012730331,2
    C--21031181(+) GTCAC-/TTTTTTT 3 -- int11Minor allele frequency- TT:0.00CSA 2
    rs358366301,2
    C--21032162(+) AAAGA-/TTTTTT 3 -- int10--------
    rs342132611,2
    C--21035261(+) TGTAT-/T/TT  
            
    TTTTT
    3 -- int11NA 2
    rs1419785691,2
    C--21036213(+) TAAAC-/ATATGCA 3 -- int10--------
    rs664678571,2
    C--21036214(+) ACATG-/ATCATTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for COG6 (40229764 - 40365802 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for COG6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1012CNV Insertion18451855
    esv1608257CNV Insertion17803354
    nsv471130CNV Loss18288195
    nsv523666CNV Loss19592680
    esv33028CNV Gain17666407
    nsv832586CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): COG6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COG6
    DNA2.0 Custom Variant and Variant Library Synthesis for COG6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606977   
    OMIM disorders: 614576  615328  
    UniProtKB/Swiss-Prot: COG6_HUMAN, Q9Y2V7
  • Congenital disorder of glycosylation 2L (CDG2L) [MIM:614576]: A multisystem disorder caused by a defect
    in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of
    glycosylation result in a wide variety of clinical features, such as defects in the nervous system development,
    psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad
    spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation,
    and maintenance of cell functions. Clinical features of CDG2L include neonatal intractable focal seizures,
    vomiting, loss of consciousness, intracranial bleeding due to vitamin K deficiency, and death in infancy.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Shaheen syndrome (SHNS) [MIM:615328]: An autosomal recessive form of syndromic mental retardation.
    Affected individuals show severe intellectual disability, hypohidrosis, dental enamel hypoplasia, and
    hyperkeratosis of the palms and soles. Some may develop mild microcephaly. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 5 diseases for COG6:    
    About MalaCards
    shaheen syndrome    congenital disorder of glycosylation, type iih    congenital disorder of glycosylation type iil    hypohidrosis
    diabetic cataract


    Find genes that share disorders with COG6           About GenesLikeMe

    Genetic Association Database (GAD): COG6

    Export disorders for COG6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COG6 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with COG6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PubMed id 11980916)1, 2, 3 Ungar D.... Waters M.G. (J. Cell Biol. 2002)
    2. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. (PubMed id 18369459)1, 4, 9 Liu Y....Bowcock A.M. (PLoS Genet. 2008)
    3. A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency. (PubMed id 23606727)1, 2 Shaheen R....Alkuraya F.S. (J. Med. Genet. 2013)
    4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    5. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    6. COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity. (PubMed id 23057818)1 Kudlyk T....Lupashin V. (Traffic 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. [Association study on the microRNA-1 target gene polymorphism and the risk of premature coronary artery disease]. (PubMed id 22883088)1 Zhang J.J....Wang B. (Zhonghua Xin Xue Guan Bing Za Zhi 2012)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57511 HGNC: 18621 AceView: COG6 Ensembl:ENSG00000133103 euGenes: HUgn57511
    ECgene: COG6 H-InvDB: COG6

    (According to HUGE)
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    HUGE: KIAA1134

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COG6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COG6 gene:
    Search GeneIP for patents involving COG6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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