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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COG6 Gene

protein-coding GIFtS: 50
GCID: GC13P040229

component of oligomeric golgi complex 6

Explore 6 diseases affiliated with
COG6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Component Of Oligomeric Golgi Complex 6¹ ² ³		CDG2L²
COD2¹ ² ⁵		Complexed With Dor1p 2²
KIAA1134¹ ³ ⁵		Conserved Oligomeric Golgi Complex Protein 6²
COG Complex Subunit 6² ³		Conserved Oligomeric Golgi Complex Subunit 6²

External Ids:	HGNC: 18621¹	Entrez Gene: 57511²	Ensembl: ENSG00000133103⁷	OMIM: 606977⁵	UniProtKB: Q9Y2V7³

ORGUL members:
	NONCODE:n407274

Export aliases for COG6 gene to outside databases

Previous GC identifers: GC13P038216 GC13P034216 GC13P039166 GC13P038027 GC13P039127 GC13P021028

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COG6:

This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure

and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex

components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript

variants.(provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: COG6_HUMAN, Q9Y2V7

Function: Required for normal Golgi function (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COG6 gene promoter:
HOXA9 HOXA9B Pax-2 Pax-2a Evi-1 Meis-1b POU2F1 POU2F1a TGIF Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COG6 promoter sequence

Search SABiosciences Chromatin IP Primers for COG6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COG6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q13.2

COG6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COG6 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P040229: view genomic region (about GC identifiers)

Start:	40,229,764 bp from pter	End:	40,365,802 bp from pter
Size:	136,039 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COG6_HUMAN, Q9Y2V7 (See protein sequence)

Recommended Name: Conserved oligomeric Golgi complex subunit 6

Size: 657 amino acids; 73279 Da

Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is

required for normal Golgi morphology and localization (By similarity)

Subcellular location: Golgi apparatus membrane; Peripheral membrane protein (By similarity)

Sequence caution: Sequence=AAD29633.1; Type=Erroneous translation; Note=Wrong choice of CDS;

Secondary accessions: Q5T0U1 Q6AI19 Q86V49 Q9ULT5

Alternative splicing: 3 isoforms: Q9Y2V7-1 Q9Y2V7-2 Q9Y2V7-4 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for COG6: NX_Q9Y2V7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y2V7

COG6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001138551.1 NP_065802.1

ENSEMBL proteins:

ENSP00000403733 ENSP00000441297 ENSP00000440438 ENSP00000440473 ENSP00000412877

ENSP00000397441 ENSP00000348983 ENSP00000445217

Human Recombinant Protein Products:

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	Novus Biologicals COG6 Protein Novus Biologicals COG6 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for COG6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0017119	Golgi transport complex	IDA	15047703

COG6 for ontologies About GeneDecksing

COG6 Antibody Products:

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	Uscn Antibodies for COG6
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Assay Products for COG6:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for COG6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COG6 for domains About GeneDecksing

1 InterPro domain/family:

IPR010490 COG6

Graphical View of Domain Structure for InterPro Entry Q9Y2V7

ProtoNet protein and cluster: Q9Y2V7

1 Blocks protein family: IPB010490 Conserved oligomeric complex COG6

UniProtKB/Swiss-Prot: COG6_HUMAN, Q9Y2V7

Similarity: Belongs to the COG6 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: COG6_HUMAN, Q9Y2V7

Function: Required for normal Golgi function (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): COG6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COG6
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate COG6 (see all 9):
		hsa-miR-3200-5p hsa-miR-2909 hsa-miR-548aa hsa-miR-659 hsa-miR-9 hsa-miR-550b hsa-miR-889 hsa-miR-32*

		SwitchGear 3'UTR luciferase reporter plasmid: COG6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COG6 (see all 7) OriGene shRNA RFP: COG6 Browse OriGene siRNA
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for COG6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COG6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COG6 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): COG6 (NM_020751)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COG6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COG6
		Search LifeMap BioReagents cell lines for COG6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for COG6

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/16 Interacting proteins for COG6 (Q9Y2V7³ ENSP00000397441⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EXOC3	O60645³, ENSP00000323377⁴	I2D: score=4 STRING: ENSP00000323377
COG3	Q96JB2³, ENSP00000258654⁴	I2D: score=1 STRING: ENSP00000258654
COG8	Q96MW5³, ENSP00000305459⁴	I2D: score=1 STRING: ENSP00000305459
COPS7B	Q9H9Q2³	I2D: score=3
SMARCD1	Q96GM5³	I2D: score=3

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006891	intra-Golgi vesicle-mediated transport	IEA	--
GO:0015031	protein transport	IEA	--
GO:0070085	glycosylation	IMP	--

COG6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COG6
Search CenterWatch for drugs/clinical trials and news about COG6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COG6 gene (2 alternative transcripts):

NM_001145079.1 NM_020751.2

Unigene Cluster for COG6:

Component of oligomeric golgi complex 6

Hs.507805 [show with all ESTs]

Unigene Representative Sequence: NM_001145079

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000416691(uc010acb.2) ENST00000542266 ENST00000543790 ENST00000543804

ENST00000422759 ENST00000455146(uc001uxh.2) ENST00000356576(uc001uxi.2)

ENST00000536488 ENST00000537156 ENST00000465775 ENST00000460701

miRNA Products:		OriGene 3'-UTR Clone (see all 2): COG6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COG6
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate COG6 (see all 9):
		hsa-miR-3200-5p hsa-miR-2909 hsa-miR-548aa hsa-miR-659 hsa-miR-9 hsa-miR-550b hsa-miR-889 hsa-miR-32*

		SwitchGear 3'UTR luciferase reporter plasmid: COG6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COG6 (see all 7) OriGene shRNA RFP: COG6 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COG6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COG6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COG6 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): COG6 (NM_020751)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COG6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COG6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COG6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COG6

Additional cDNA sequence:

AB032960.1 AF116827.1 AK026638.1 AK294443.1 AK310953.1 BC027469.1 BC051723.1 CR627406.1

NR_026745.1

8 DOTS entries:

DT.95271521 DT.214834 DT.100784954 DT.95271518 DT.120782359 DT.75169227 DT.91721653 DT.95094696

22 AceView cDNA sequences:

BU160952 CB989039 CD109872 BM477584 BQ880684 BI457596 AL599284 AL549064

BI463631 BX503552 AW500299 BI547815 BQ068185 AA358192 AV694533 AI525848

NM_020751 BC051723 AB032960 AF116827 CR627406 AK026638

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for COG6 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21
SP1:																	-
SP2:							-										-
SP3:							-										-																																-
SP4:
SP5:

ECgene alternative splicing isoforms for COG6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COG6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTAACTGG

About this image
See COG6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COG6

SOURCE GeneReport for Unigene cluster: Hs.507805

SABiosciences Custom PCR Arrays for COG6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COG6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COG6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG6 gene from 10/36 species (see all 36) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cog6^{1 , 5}	component of oligomeric golgi complex 6^{1, 5}	85.44(n)¹ 91.02(a)¹		3 (24.10 cM)⁵ 67542¹ NM_026225.3¹ NP_080501.2¹ 52982123⁵
chicken (Gallus gallus)	Aves	COG6¹	component of oligomeric golgi complex 6	81.07(n) 90.24(a)		418888 XM_417082.3 XP_417082.2
lizard (Anolis carolinensis)	Reptilia	COG6⁶	--	78(a)	1 ↔ 1	1(132332833-132365095)
African clawed frog (Xenopus laevis)	Amphibia	MGC68662²	hypothetical protein MGC68662	78.66(n)		BC060478.1
zebrafish (Danio rerio)	Actinopterygii	BC051776.1²	--	74.98(n)		393290 BC051776.1
fruit fly (Drosophila melanogaster)	Insecta	CG1968^{1 , 3}	CG1968¹	50(a)³ 50.83(n)¹ 43.23(a)¹		45C3³ 35953¹ NM_165673.2¹ NP_724783.1¹
worm (Caenorhabditis elegans)	Secernentea	K07C11.9³	--	22(a)		V(8221060-8223802) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	COG6¹	Cog6p	38.83(n) 22.28(a)		855687 NP_014357.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G31780¹	hypothetical protein	46.25(n) 38.92(a)		840065 NM_102912.4 NP_174458.2
rice (Oryza sativa)	Liliopsida	Os.43918²	Oryza sativa (japonica cultivar-group) Hypothetical more	78.53(n)		NM_187606.1

ENSEMBL Gene Tree for COG6 (if available)
TreeFam Gene Tree for COG6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6650472^1,2	H	--	21027334(+)	`catgaA/Gctgac`	3	--	us2k¹		4		NS EA	416
rs75955510^1,2	C,	--	21027431(+)	`TCACAT/AAAAGA`	3	--	us2k¹		2		WA	120
rs201755880^1,2	C	--	21028061(+)	`AAAAAA/GGNNNN`	3	--	us2k¹		0	--	--	--	--
rs75556594^1,2	F,	--	21029916(+)	`AAGTCC/TCTTCA`	3	--	int¹		1		WA	118
rs35439076^1,2	C,	--	21030648(+)	`ATGGGT/-TTTTT`	3	--	int¹		1		CSA	2
rs78899599^1,2		--	21031057(+)	`TTGACA/GTCATA`	3	--	int¹		0	--	--	--	--
rs75910275^1,2	C,	--	21031087(+)	`CTCTTG/CATTTT`	3	--	int¹		2		NA	122
rs12430018^1,2	C,F,H	--	21031341(+)	`ctgtaG/Accttg`	3	--	int¹		5		NS EA NA	426
rs73179512^1,2	C,	--	21031560(+)	`ATATTC/TTGGAA`	3	--	int¹		0	--	--	--	--
rs11839208^1,2	C,F,H,	--	21031701(+)	`TTGGAA/GTAAAC`	3	--	int¹		3		NA WA	124

HapMap Linkage Disequilibrium report for COG6 (40229764 - 40365802 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for COG6
1 CNV: 4798
1 Indel: 11079
Human Gene Mutation Database (HGMD): COG6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COG6

DNA2.0 Custom Variant and Variant Library Synthesis for COG6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COG6 for disorders About GeneDecksing

OMIM gene information: 606977 OMIM disorders: --

UniProtKB/Swiss-Prot: COG6_HUMAN, Q9Y2V7

Defects in COG6 are the cause of congenital disorder of glycosylation type 2L (CDG2L) [MIM:614576]. CDG2L is a

multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum

glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in

the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and

immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic

development, differentiation, and maintenance of cell functions. Clinical features of CDG2L include neonatal

intractable focal seizures, vomiting, loss of consciousness, intracranial bleeding due to vitamin K deficiency, and

death in infancy

6 diseases for COG6: About MalaCards

congenital disorder of glycosylation psoriatic arthritis macular degeneration arthritis

psoriasis ataxia

Export disorders for COG6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for COG6 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with COG6)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PubMed id 11980916)^{1, 2, 3} Ungar D....Waters M.G. (2002)
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)^{1, 2} Hirosawa M.... Ohara O. (1999)
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. (PubMed id 18369459)^{1, 9} Liu Y....Bowcock A.M. (2008)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)¹ Kahle J.J....Zoghbi H.Y. (2011)
The COG complex interacts directly with Syntaxin 6 an d positively regulates endosome-to-TGN retrograde transport. (PubMed id 21807881)¹ Laufman O....Lev S. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Fatal outcome due to deficiency of subunit 6 of the conserved oligomeric Golgi complex leading to a new type of congenital disorders of glycosylation. (PubMed id 20605848)² Lubbehusen J.... Korner C. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57511	HGNC: 18621	AceView: COG6	Ensembl:ENSG00000133103	euGenes: HUgn57511
ECgene: COG6	H-InvDB: COG6

(According to HUGE)
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HUGE: KIAA1134

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for COG6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COG6 gene
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Patent Information for COG6 gene:
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COG6 Gene

component of oligomeric golgi complex 6

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COG6 Gene

component of oligomeric golgi complex 6

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