COG4 Gene
protein-coding GIFtS: 55
GCID: GC16M070514
|
|
component of oligomeric golgi complex 4
| |
Aliases
for COG4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Component Of Oligomeric Golgi Complex 41 2 3 | | DKFZP586E15191 | | COD11 2 5 | | Complexed With Dor1p2 | | COG Complex Subunit 42 3 | | Conserved Oligomeric Golgi Complex Protein 42 | | CDG2J2 5 | | Conserved Oligomeric Golgi Complex Subunit 42 |
Export aliases for COG4 gene to outside databasesPrevious GC identifers: GC16M061216 GC16M070934 GC16M070249 GC16M070290 GC16M069071 GC16M056346 |
Summaries
for COG4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for COG4:
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and functionof the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Twotranscript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Aug 2010)
UniProtKB/Swiss-Prot: COG4_HUMAN, Q9H9E3Function: Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transportvia its interaction with SCFD1
Gene Wiki entry for COG4
|
Genomic Views
for COG4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COG4 gene promoter:
STAT1 FOXF2 NRSF form 1 NCX/Ncx LCR-F1 NRSF form 2 Tal-1beta ITF-2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for COG4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COG4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC chromosome: 16COG4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M070514: view genomic region
(about GC identifiers)
Start:
|
70,514,471 bp from pter |
End:
|
70,557,468 bp from pter |
Size:
|
42,998 bases |
Orientation:
|
minus strand |
|
Proteins
for COG4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COG4_HUMAN, Q9H9E3 (See
protein sequence)Recommended Name: Conserved oligomeric Golgi complex subunit 4 Size: 785 amino acids; 89083 Da
Subunit: Monomer. Component of the conserved oligomeric Golgi (COG) complex which is composed of eight differentsubunits and is required for normal Golgi morphology and localization. Mediates interaction of SCFD1 with the COGcomplex. Interacts with STX5
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (Probable)
Sequence caution: Sequence=BAB15483.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from  and Proteopedia  for COG4:3HR0 (3D)
Secondary accessions: B4DMN8 C9JS23 Q96D40 Q9BRF0 Q9BVZ2 Q9H5Y4 Q9Y3W3Alternative splicing: 3 isoforms: Q9H9E3-1 Q9H9E3-2 Q9H9E3-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for COG4: NX_Q9H9E3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9E3
COG4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001182068.1 NP_056201.2
ENSEMBL proteins: ENSP00000456653 ENSP00000315775 ENSP00000432802 ENSP00000455693 ENSP00000454573 ENSP00000461912 ENSP00000434160 ENSP00000463732 ENSP00000377236
Human Recombinant Protein Products for COG4:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
COG4 for ontologies About GeneDecksing
COG4 Antibody Products:
Assay Products for COG4: |
Protein
Domains /
Families
for COG4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COG4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H9E3ProtoNet protein and cluster: Q9H9E3 UniProtKB/Swiss-Prot: COG4_HUMAN, Q9H9E3Similarity: Belongs to the COG4 family |
Function
for COG4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: COG4_HUMAN, Q9H9E3Function: Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transportvia its interaction with SCFD1 Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
COG4 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for COG4:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COG4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COG4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): COG4 (NM_015386) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COG4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG4 |
|
Pathways & Interactions
for COG4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COG4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/24 Interacting proteins for COG4 (Q9H9E31, 2, 3 ENSP000003157754) via UniProtKB, MINT, STRING, and/or I2D (see all 24)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SCFD1 | Q8WVM82, 3, ENSP000003907834 | MINT-7296985 MINT-7296900 MINT-7296997 MINT-7296837 MINT-7296817 MINT-7296950 MINT-7296858 MINT-7296787 MINT-7296930 MINT-7296769 MINT-7296883 MINT-7296802 I2D:
score=1 STRING: ENSP00000390783 | | COG3 | Q96JB22, 3, ENSP000002586544 | MINT-7296817 MINT-7296787 MINT-7296769 MINT-7296802 I2D:
score=1 STRING: ENSP00000258654 | | COG1 | Q8WTW31, 3, ENSP000002998864 | EBI-368382,EBI-368371 I2D:
score=3 STRING: ENSP00000299886 | | COG2 | Q147461, 3, ENSP000003556294 | EBI-368382,EBI-389449 I2D:
score=3 STRING: ENSP00000355629 | | SEPT2 | Q150192, 3, ENSP000003531574 | MINT-8270099 I2D:
score=2 STRING: ENSP00000353157 |
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
COG4 for ontologies About GeneDecksing
|
Drugs & Compounds
for COG4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COG4
Search CenterWatch for drugs/clinical trials and news about COG4
|
Transcripts
for COG4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COG4 gene (2 alternative transcripts): NM_001195139.1 NM_015386.2 Unigene Cluster for COG4: Component of oligomeric golgi complex 4 Hs.208680 [show with all ESTs]Unigene Representative Sequence: BX64801014 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000564415 ENST00000323786(uc002ezc.3 uc002ezd.3) ENST00000530314(uc002eze.3)
ENST00000482252(uc010cfu.3) ENST00000526700 ENST00000565715 ENST00000564315
ENST00000567244 ENST00000562200 ENST00000564653 ENST00000534772 ENST00000530160
ENST00000524584 ENST00000393612
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COG4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COG4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): COG4 (NM_015386) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COG4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG4 |
Additional cDNA sequence: AK022874.1 AK026435.1 AK096557.1 AK293235.1 AK297557.1 AL050101.1 BC000796.1 BC006306.2 BC013347.2 BC027726.2 BC072438.1 BC128144.1 BC128145.1 BX648010.1 22 DOTS entries: DT.100670471 DT.100730780 DT.100816127 DT.316115 DT.100812988 DT.100812987 DT.97851961 DT.100816132 DT.92451125 DT.102825854 DT.120690638 DT.91818536 DT.92451123 DT.92451145 DT.100719520 DT.120690734 DT.120690755 DT.100801567 DT.100831553 DT.120690635 DT.92451119 DT.120690717 24/406 AceView cDNA sequences (see all 406): BM044494 CR601969 BM550673 BU630342 AI382773 AI364170 AB088369 BQ689620 T31346 AI685978 BQ066375 BQ185791 BU620219 AU154526 BQ019415 AK096557 AL050101 BM818073 BU737929 AU125729 BM910766 BM011683 BG747770 BM563035
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for COG4 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COG4
|
Expression
for COG4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COG4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGGTCAGT
About this image
See COG4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COG4
SOURCE GeneReport for Unigene cluster: Hs.208680
SABiosciences Custom PCR Arrays for COG4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COG4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COG4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COG4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COG4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG4 |
Orthologs
for COG4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for COG4 gene from 9/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cog41 , 5 |
component of oligomeric golgi complex 41, 5 |
89.68(n)1
94.39(a)1 |
|
8 (57.76 cM)5
1023391 NM_133973.21 NP_598734.11
1108466005 |
chicken
(Gallus gallus) |
Aves |
COG41 |
component of oligomeric golgi complex 4 |
80.17(n)
86.01(a) |
|
415681 NM_001012775.1 NP_001012793.1 |
lizard
(Anolis carolinensis) |
Reptilia |
COG46 |
-- |
85(a) |
1 ↔ 1 |
GL343539.1(65140-79771) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.2142 |
Transcribed sequence with moderate similarity to protein more |
77.67(n) |
|
57066186 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG74561 , 3 |
CG74561 |
38(a)3
50.8(n)1
40.79(a)1 |
|
31F13
344421 NM_135569.31 NP_609413.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y51H7C.6a3
cogc-41 |
Protein COGC-41 |
32(a)
(best of 2)3
46.53(n)1
34.21(a)1 |
|
II(1403616-1408976)3
1735181 NM_061565.31 NP_493966.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
COG4(YPR105C)4
COG41 |
Essential component of the conserved oligomeric Golgi more4
Cog4p1 |
37.56(n)1
22.62(a)1 |
|
16(739569-736984)4
8562201, 4 NP_015430.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G014001 |
hypothetical protein |
46.4(n)
35.23(a) |
|
827943 NM_001160726.1 NP_001154198.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.156102 |
Transcribed sequence with moderate similarity to protein more |
71.67(n) |
|
CB633133.1 |
ENSEMBL Gene Tree for COG4 (if available)
TreeFam Gene Tree for COG4 (if available) |
Paralogs
for COG4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for COG4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COG4 (70514471 - 70557468 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for COG4
1 CNV: 4965
6 Indels: 102320 61534 45460 25673 42327 45459
Human Gene Mutation Database (HGMD): COG4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COG4 |
|
Disorders
/ Diseases
for COG4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COG4 for disorders About GeneDecksing
OMIM gene information: 606976
OMIM disorders: 613489
UniProtKB/Swiss-Prot: COG4_HUMAN, Q9H9E3
Defects in COG4 are the cause of congenital disorder of glycosylation type 2J (CDG2J) [MIM:613489]. It is amultisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serumglycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects inthe nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, andimmunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonicdevelopment, differentiation, and maintenance of cell functions
4  diseases for COG4: About MalaCardscongenital disorder of glycosylation congenital disorder of glycosylation type ii oculocerebrorenal syndrome hypotonia
1 disease from the University of Copenhagen DISEASES database for COG4:Oculocerebrorenal syndrome Human Genome Epidemiology (HuGE) Navigator: COG4 (1 document)
Export disorders for COG4 gene to outside databases
|
Publications
for COG4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COG4 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with COG4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural basis for a human glycosylation disorder c aused by mutation of the COG4 gene. (PubMed id 19651599)1, 2 Richardson B.C....Hughson F.M. (2009)
- Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. (PubMed id 19536132)1, 2 Laufman O....Lev S. (2009)
- Golgi function and dysfunction in the first COG4-defi cient CDG type II patient. (PubMed id 19494034)1, 2 Reynders E....Matthijs G. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
- Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PubMed id 11980916)1, 3 Ungar D....Waters M.G. (2002)
- The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. (PubMed id 11703943)1, 2 Whyte J.R. and Munro S. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for COG4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COG4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COG4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COG4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COG4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COG4 gene:
Search GeneIP for patents involving COG4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for COG4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COG4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COG4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COG4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COG4 | | OriGene 3'-UTR Clone for COG4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COG4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COG4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COG4 | | OriGene Custom Protein Services for COG4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COG4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COG4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COG4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COG4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COG4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COG4 |
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| | | | Search Tocris compounds for COG4 |
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 | | | COG4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG4 |
|  |  |  |  | | | | ThermoFisher Antibodies for COG4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG4 |
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