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Aliases for COG3 Gene

Aliases for COG3 Gene

  • Component Of Oligomeric Golgi Complex 3 2 3 4
  • SEC34 3 4 6
  • Vesicle-Docking Protein SEC34 Homolog 3 4
  • COG Complex Subunit 3 3 4
  • P94 3 4
  • Conserved Oligomeric Golgi Complex Subunit 3 3
  • Tethering Factor SEC34 3

External Ids for COG3 Gene

Summaries for COG3 Gene

Entrez Gene Summary for COG3 Gene

  • This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]

GeneCards Summary for COG3 Gene

COG3 (Component Of Oligomeric Golgi Complex 3) is a Protein Coding gene. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot for COG3 Gene

  • Involved in ER-Golgi transport.

Gene Wiki entry for COG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COG3 Gene

Genomics for COG3 Gene

Genomic Location for COG3 Gene

45,464,895 bp from pter
45,536,698 bp from pter
71,804 bases
Plus strand

Genomic View for COG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COG3 Gene

Regulatory Elements for COG3 Gene

Proteins for COG3 Gene

  • Protein details for COG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Conserved oligomeric Golgi complex subunit 3
    Protein Accession:
    Secondary Accessions:
    • B2RAW5
    • Q5VT70
    • Q8IXX4
    • Q9BZ92

    Protein attributes for COG3 Gene

    828 amino acids
    Molecular mass:
    94096 Da
    Quaternary structure:
    • Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Interacts with TMEM115.

    Alternative splice isoforms for COG3 Gene


neXtProt entry for COG3 Gene

Proteomics data for COG3 Gene at MOPED

Post-translational modifications for COG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COG3 Gene

No data available for DME Specific Peptides for COG3 Gene

Domains for COG3 Gene

Gene Families for COG3 Gene

  • COG :Components of oligomeric golgi complex

Protein Domains for COG3 Gene



  • Belongs to the COG3 family.:
    • Q96JB2
genes like me logo Genes that share domains with COG3: view

Function for COG3 Gene

Molecular function for COG3 Gene

UniProtKB/Swiss-Prot Function: Involved in ER-Golgi transport.

Gene Ontology (GO) - Molecular Function for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19536132
GO:0008565 protein transporter activity IDA 11929878
genes like me logo Genes that share ontologies with COG3: view
genes like me logo Genes that share phenotypes with COG3: view

miRNA for COG3 Gene

miRTarBase miRNAs that target COG3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COG3 Gene

Localization for COG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COG3 Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with the peripheral membrane of cis/medial cisternae.

Subcellular locations from

Jensen Localization Image for COG3 Gene COMPARTMENTS Subcellular localization image for COG3 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network IEA --
genes like me logo Genes that share ontologies with COG3: view

Pathways for COG3 Gene

SuperPathways for COG3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000301 retrograde transport, vesicle recycling within Golgi IBA --
GO:0006486 protein glycosylation IMP 16420527
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IDA 11929878
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 16420527
genes like me logo Genes that share ontologies with COG3: view

No data available for Pathways by source for COG3 Gene

Transcripts for COG3 Gene

Unigene Clusters for COG3 Gene

Component of oligomeric golgi complex 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COG3 Gene

No ASD Table

Relevant External Links for COG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COG3 Gene

mRNA expression in normal human tissues for COG3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COG3 Gene

SOURCE GeneReport for Unigene cluster for COG3 Gene Hs.507948

mRNA Expression by UniProt/SwissProt for COG3 Gene

Tissue specificity: Widely expressed with highest levels in pancreas and testis and lowest levels in lung.
genes like me logo Genes that share expressions with COG3: view

Orthologs for COG3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COG3 36
  • 99.52 (n)
  • 100 (a)
COG3 37
  • 100 (a)
(Bos Taurus)
Mammalia COG3 36
  • 92.07 (n)
  • 95.65 (a)
COG3 37
  • 92 (a)
(Canis familiaris)
Mammalia COG3 36
  • 93 (n)
  • 95.29 (a)
COG3 37
  • 92 (a)
(Mus musculus)
Mammalia Cog3 36
  • 90.04 (n)
  • 95.94 (a)
Cog3 16
Cog3 37
  • 96 (a)
(Monodelphis domestica)
Mammalia COG3 37
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia COG3 37
  • 89 (a)
(Rattus norvegicus)
Mammalia Cog3 36
  • 89.91 (n)
  • 96.43 (a)
(Gallus gallus)
Aves COG3 36
  • 81.22 (n)
  • 88.44 (a)
COG3 37
  • 88 (a)
(Anolis carolinensis)
Reptilia COG3 37
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cog3 36
  • 76.92 (n)
  • 83.27 (a)
Str.1471 36
(Danio rerio)
Actinopterygii cog3 36
  • 70.93 (n)
  • 78.76 (a)
cog3 37
  • 78 (a)
cog3 37
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003970 36
  • 51.73 (n)
  • 46.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cog3 36
  • 51.07 (n)
  • 46.15 (a)
Cog3 37
  • 39 (a)
CG3248 38
  • 42 (a)
(Caenorhabditis elegans)
Secernentea cogc-3 36
  • 48.33 (n)
  • 35.16 (a)
cogc-3 37
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COG3 37
  • 20 (a)
COG3 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73430 36
  • 48.57 (n)
  • 39.02 (a)
(Oryza sativa)
Liliopsida Os.24582 36
Os08g0451000 36
  • 48.57 (n)
  • 38.23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12103 36
Species with no ortholog for COG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COG3 Gene

Gene Tree for COG3 (if available)
Gene Tree for COG3 (if available)

Paralogs for COG3 Gene

No data available for Paralogs for COG3 Gene

Variants for COG3 Gene

Sequence variations from dbSNP and Humsavar for COG3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs942890 -- 45,467,755(-) AAAGA(A/G)TAGTA intron-variant
rs942891 -- 45,517,987(-) TTTCT(A/G)TAAGA intron-variant
rs999252 -- 45,522,726(+) GTAAT(A/G)CTATT intron-variant
rs1061694 -- 45,534,891(+) CAAAG(A/T)GTTAC utr-variant-3-prime, downstream-variant-500B
rs1359544 -- 45,483,020(+) tgtat(G/T)gagct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COG3 Gene

Variant ID Type Subtype PubMed ID
dgv250e201 CNV Deletion 23290073
nsv455875 CNV Loss 19166990
nsv510583 CNV Loss 20534489
esv1166784 CNV Deletion 17803354
esv1140090 CNV Deletion 17803354
esv271929 CNV Insertion 20981092

Relevant External Links for COG3 Gene

HapMap Linkage Disequilibrium report

Disorders for COG3 Gene

Relevant External Links for COG3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with COG3: view

No data available for UniProtKB/Swiss-Prot for COG3 Gene

Publications for COG3 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of a human ortholog of Sec34p as a component of the cis-Golgi vesicle tethering machinery. (PMID: 11292827) Suvorova E.S. … Lupashin V.V. (J. Biol. Chem. 2001) 3 4
  4. Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. (PMID: 11929878) Loh E. … Hong W. (J. Biol. Chem. 2002) 3 4
  5. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PMID: 11980916) Ungar D. … Waters M.G. (J. Cell Biol. 2002) 2 3

Products for COG3 Gene

Sources for COG3 Gene

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