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Aliases for COG3 Gene

Aliases for COG3 Gene

  • Component Of Oligomeric Golgi Complex 3 2 3 4
  • SEC34 3 4 6
  • Vesicle-Docking Protein SEC34 Homolog 3 4
  • COG Complex Subunit 3 3 4
  • P94 3 4
  • Conserved Oligomeric Golgi Complex Subunit 3 3
  • Tethering Factor SEC34 3

External Ids for COG3 Gene

Previous GeneCards Identifiers for COG3 Gene

  • GC13P044039
  • GC13P040026
  • GC13P044975
  • GC13P043837
  • GC13P044937
  • GC13P046039
  • GC13P026835

Summaries for COG3 Gene

Entrez Gene Summary for COG3 Gene

  • This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]

GeneCards Summary for COG3 Gene

COG3 (Component Of Oligomeric Golgi Complex 3) is a Protein Coding gene. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot for COG3 Gene

  • Involved in ER-Golgi transport.

Gene Wiki entry for COG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COG3 Gene

Genomics for COG3 Gene

Regulatory Elements for COG3 Gene

Genomic Location for COG3 Gene

Start:
45,464,895 bp from pter
End:
45,536,698 bp from pter
Size:
71,804 bases
Orientation:
Plus strand

Genomic View for COG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COG3 Gene

Proteins for COG3 Gene

  • Protein details for COG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JB2-COG3_HUMAN
    Recommended name:
    Conserved oligomeric Golgi complex subunit 3
    Protein Accession:
    Q96JB2
    Secondary Accessions:
    • B2RAW5
    • Q5VT70
    • Q8IXX4
    • Q9BZ92

    Protein attributes for COG3 Gene

    Size:
    828 amino acids
    Molecular mass:
    94096 Da
    Quaternary structure:
    • Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Interacts with TMEM115.

    Alternative splice isoforms for COG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COG3 Gene

Proteomics data for COG3 Gene at MOPED

Post-translational modifications for COG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COG3 Gene

No data available for DME Specific Peptides for COG3 Gene

Domains for COG3 Gene

Gene Families for COG3 Gene

HGNC:
  • COG :Components of oligomeric golgi complex

Protein Domains for COG3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JB2

UniProtKB/Swiss-Prot:

COG3_HUMAN :
  • Q96JB2
Family:
  • Belongs to the COG3 family.
genes like me logo Genes that share domains with COG3: view

Function for COG3 Gene

Molecular function for COG3 Gene

UniProtKB/Swiss-Prot Function: Involved in ER-Golgi transport.

Gene Ontology (GO) - Molecular Function for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19536132
GO:0008565 protein transporter activity IDA 11929878
genes like me logo Genes that share ontologies with COG3: view
genes like me logo Genes that share phenotypes with COG3: view

Animal Model Products

CRISPR Products

miRNA for COG3 Gene

miRTarBase miRNAs that target COG3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COG3 Gene

Localization for COG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COG3 Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with the peripheral membrane of cis/medial cisternae.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COG3 Gene COMPARTMENTS Subcellular localization image for COG3 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network IEA --
genes like me logo Genes that share ontologies with COG3: view

Pathways for COG3 Gene

SuperPathways for COG3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000301 retrograde transport, vesicle recycling within Golgi IBA --
GO:0006486 protein glycosylation IMP 16420527
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IDA 11929878
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 16420527
genes like me logo Genes that share ontologies with COG3: view

No data available for Pathways by source for COG3 Gene

Transcripts for COG3 Gene

Unigene Clusters for COG3 Gene

Component of oligomeric golgi complex 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COG3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for COG3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COG3 Gene

No ASD Table

Relevant External Links for COG3 Gene

GeneLoc Exon Structure for
COG3
ECgene alternative splicing isoforms for
COG3

Expression for COG3 Gene

mRNA expression in normal human tissues for COG3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COG3 Gene

SOURCE GeneReport for Unigene cluster for COG3 Gene Hs.507948

mRNA Expression by UniProt/SwissProt for COG3 Gene

Q96JB2-COG3_HUMAN
Tissue specificity: Widely expressed with highest levels in pancreas and testis and lowest levels in lung.
genes like me logo Genes that share expressions with COG3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COG3 Gene

Orthologs for COG3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COG3 35
  • 99.52 (n)
  • 100 (a)
COG3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COG3 35
  • 92.07 (n)
  • 95.65 (a)
COG3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COG3 35
  • 93 (n)
  • 95.29 (a)
COG3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cog3 35
  • 90.04 (n)
  • 95.94 (a)
Cog3 16
Cog3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COG3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COG3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cog3 35
  • 89.91 (n)
  • 96.43 (a)
chicken
(Gallus gallus)
Aves COG3 35
  • 81.22 (n)
  • 88.44 (a)
COG3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COG3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cog3 35
  • 76.92 (n)
  • 83.27 (a)
Str.1471 35
zebrafish
(Danio rerio)
Actinopterygii cog3 35
  • 70.93 (n)
  • 78.76 (a)
cog3 36
  • 78 (a)
OneToMany
cog3 36
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003970 35
  • 51.73 (n)
  • 46.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cog3 35
  • 51.07 (n)
  • 46.15 (a)
Cog3 36
  • 39 (a)
OneToOne
CG3248 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea cogc-3 35
  • 48.33 (n)
  • 35.16 (a)
cogc-3 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COG3 36
  • 20 (a)
OneToOne
COG3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73430 35
  • 48.57 (n)
  • 39.02 (a)
rice
(Oryza sativa)
Liliopsida Os.24582 35
Os08g0451000 35
  • 48.57 (n)
  • 38.23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12103 35
Species with no ortholog for COG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COG3 Gene

ENSEMBL:
Gene Tree for COG3 (if available)
TreeFam:
Gene Tree for COG3 (if available)

Paralogs for COG3 Gene

No data available for Paralogs for COG3 Gene

Variants for COG3 Gene

Sequence variations from dbSNP and Humsavar for COG3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs942890 -- 45,467,755(-) AAAGA(A/G)TAGTA intron-variant
rs942891 -- 45,517,987(-) TTTCT(A/G)TAAGA intron-variant
rs999252 -- 45,522,726(+) GTAAT(A/G)CTATT intron-variant
rs1061694 -- 45,534,891(+) CAAAG(A/T)GTTAC utr-variant-3-prime, downstream-variant-500B
rs1359544 -- 45,483,020(+) tgtat(G/T)gagct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COG3 Gene

Variant ID Type Subtype PubMed ID
dgv250e201 CNV Deletion 23290073
nsv455875 CNV Loss 19166990
nsv510583 CNV Loss 20534489
esv1166784 CNV Deletion 17803354
esv1140090 CNV Deletion 17803354
esv271929 CNV Insertion 20981092

Relevant External Links for COG3 Gene

HapMap Linkage Disequilibrium report
COG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COG3 Gene

Disorders for COG3 Gene

Relevant External Links for COG3

Genetic Association Database (GAD)
COG3
Human Genome Epidemiology (HuGE) Navigator
COG3
genes like me logo Genes that share disorders with COG3: view

No data available for UniProtKB/Swiss-Prot for COG3 Gene

Publications for COG3 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of a human ortholog of Sec34p as a component of the cis-Golgi vesicle tethering machinery. (PMID: 11292827) Suvorova E.S. … Lupashin V.V. (J. Biol. Chem. 2001) 3 4
  4. Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. (PMID: 11929878) Loh E. … Hong W. (J. Biol. Chem. 2002) 3 4
  5. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PMID: 11980916) Ungar D. … Waters M.G. (J. Cell Biol. 2002) 2 3

Products for COG3 Gene

Sources for COG3 Gene

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