COG3 Gene
protein-coding GIFtS: 50
GCID: GC13P046039
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component of oligomeric golgi complex 3
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Aliases
for COG3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Component Of Oligomeric Golgi Complex 31 2 3 | | P941 | | SEC341 2 3 5 | | Conserved Oligomeric Golgi Complex Subunit 32 | | Vesicle-Docking Protein SEC34 Homolog2 3 | | Tethering Factor SEC342 | | COG Complex Subunit 32 3 | | |
Export aliases for COG3 gene to outside databasesPrevious GC identifers: GC13P044039 GC13P040026 GC13P044975 GC13P043837 GC13P044937 GC13P026835 |
Summaries
for COG3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for COG3:
This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight differentsubunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multipledeficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.(provided byRefSeq, Jun 2011)
UniProtKB/Swiss-Prot: COG3_HUMAN, Q96JB2Function: Involved in ER-Golgi transport
Gene Wiki entry for COG3
|
Genomic Views
for COG3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COG3 gene promoter:
GCNF NF-AT c-Rel NF-AT4 NF-AT2 GCNF-1 NF-AT3 Pax-4a GCNF-2 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for COG3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COG3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.13 Ensembl cytogenetic band: 13q14.13 HGNC cytogenetic band: 13q14.11COG3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P046039: view genomic region
(about GC identifiers)
Start:
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46,039,060 bp from pter |
End:
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46,110,765 bp from pter |
Size:
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71,706 bases |
Orientation:
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plus strand |
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Proteins
for COG3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COG3_HUMAN, Q96JB2 (See
protein sequence)Recommended Name: Conserved oligomeric Golgi complex subunit 3 Size: 828 amino acids; 94096 Da
Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and isrequired for normal Golgi morphology and localization (By similarity)
Subcellular location: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with theperipheral membrane of cis/medial cisternae
Secondary accessions: B2RAW5 Q5VT70 Q8IXX4 Q9BZ92Alternative splicing: 2 isoforms: Q96JB2-1 Q96JB2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for COG3: NX_Q96JB2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96JB2
COG3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_113619.2
ENSEMBL proteins: ENSP00000258654
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
COG3 for ontologies About GeneDecksing
COG3 Antibody Products:
Assay Products for COG3: |
Protein
Domains /
Families
for COG3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COG3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96JB2ProtoNet protein and cluster: Q96JB2 1 Blocks protein family: IPB007265 Sec34-like protein
UniProtKB/Swiss-Prot: COG3_HUMAN, Q96JB2Similarity: Belongs to the COG3 family |
Function
for COG3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COG3_HUMAN, Q96JB2Function: Involved in ER-Golgi transport
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COG3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COG3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): COG3 (NM_031431) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COG3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
COG3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for COG3:
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Pathways & Interactions
for COG3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COG3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/81 Interacting proteins for COG3 (Q96JB22, 3 ENSP000002586544) via UniProtKB, MINT, STRING, and/or I2D (see all 81)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
COG3 for ontologies About GeneDecksing
|
Drugs & Compounds
for COG3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COG3
Search CenterWatch for drugs/clinical trials and news about COG3
|
Transcripts
for COG3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COG3 gene (2 alternative transcripts): NM_031431.3 NM_001204476.1 Unigene Cluster for COG3: Component of oligomeric golgi complex 3 Hs.507948 [show with all ESTs]Unigene Representative Sequence: NM_0314314 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000349995(uc010tfu.2 uc001vai.3 uc001vak.3 uc010tfv.2 uc010aci.3)
ENST00000476702 ENST00000465942 ENST00000486940
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COG3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COG3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): COG3 (NM_031431) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COG3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG3 |
Additional cDNA sequence: AF111707.1 AF131829.1 AF332595.1 AF349676.1 AK026305.1 AK026994.1 AK057884.1 AK074374.1 AK225466.1 AK225952.1 AK294959.1 AK304248.1 AK314387.1 BC038953.1 BX648211.1 15 DOTS entries: DT.317524 DT.317523 DT.120781255 DT.91756988 DT.75195575 DT.100733653 DT.40120867 DT.100806237 DT.100776939 DT.120781238 DT.100681195 DT.102821681 DT.120781254 DT.91806579 DT.97824744 24/162 AceView cDNA sequences (see all 162): W02347 AI249761 AF131829 AA501982 AA404461 AI042599 BQ718157 T34468 AW103697 AA744764 AI683466 AI141864 CD108885 AA461166 AW517527 AA243717 BM980548 CA418431 N39675 BP356228 BQ722113 H57063 CR609778 Z40695
GeneLoc Exon Structure
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Expression
for COG3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTATTGTAC
About this image
See COG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COG3
SOURCE GeneReport for Unigene cluster: Hs.507948
UniProtKB/Swiss-Prot: COG3_HUMAN, Q96JB2Tissue specificity: Widely expressed with highest levels in pancreas and testis and lowest levels in lung
SABiosciences Custom PCR Arrays for COG3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COG3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COG3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG3 |
Orthologs
for COG3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for COG3 gene from 10/32 species (see all 32) About this table
ENSEMBL Gene Tree for COG3 (if available)
TreeFam Gene Tree for COG3 (if available) |
Paralogs
for COG3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for COG3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COG3 (46039060 - 46110765 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for COG3
2 Indels: 25254 25253 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COG3 |
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Disorders
/ Diseases
for COG3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COG3 for disorders About GeneDecksing
OMIM gene information: 606975
OMIM disorders: --
2  diseases for COG3: About MalaCardsstomatitis neuronitis
Human Genome Epidemiology (HuGE) Navigator: COG3 (1 document)
Export disorders for COG3 gene to outside databases
|
Publications
for COG3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COG3 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with COG3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PubMed id 11980916)1, 3 Ungar D....Waters M.G. (2002)
- Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. (PubMed id 11929878)1, 2 Loh E. and Hong W. (2002)
- Identification of a human ortholog of Sec34p as a component of the cis-Golgi vesicle tethering machinery. (PubMed id 11292827)1, 2 Suvorova E.S.... Lupashin V.V. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for COG3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing COG3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COG3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COG3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COG3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for COG3 gene:
Search GeneIP for patents involving COG3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COG3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COG3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COG3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COG3 | | | OriGene Protein Over-expression Lysate for COG3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COG3 | | OriGene 3'-UTR Clone for COG3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COG3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COG3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COG3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COG3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COG3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COG3 |
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 | | | COG3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG3 |
|  |  |  | | | | Search ThermoFisher Antibodies for COG3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG3 |
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