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Aliases for COG3 Gene

Aliases for COG3 Gene

  • Component Of Oligomeric Golgi Complex 3 2 3 4 5
  • Vesicle-Docking Protein SEC34 Homolog 3 4
  • COG Complex Subunit 3 3 4
  • SEC34 3 4
  • P94 3 4
  • Tethering Factor SEC34 3

External Ids for COG3 Gene

Previous GeneCards Identifiers for COG3 Gene

  • GC13P044039
  • GC13P040026
  • GC13P044975
  • GC13P043837
  • GC13P044937
  • GC13P046039
  • GC13P026835

Summaries for COG3 Gene

Entrez Gene Summary for COG3 Gene

  • This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]

GeneCards Summary for COG3 Gene

COG3 (Component Of Oligomeric Golgi Complex 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Golgi-to-ER retrograde transport. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot for COG3 Gene

  • Involved in ER-Golgi transport.

Gene Wiki entry for COG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COG3 Gene

Genomics for COG3 Gene

Regulatory Elements for COG3 Gene

Enhancers for COG3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COG3 on UCSC Golden Path with GeneCards custom track

Promoters for COG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for COG3 Gene

45,464,895 bp from pter
45,536,698 bp from pter
71,804 bases
Plus strand

Genomic View for COG3 Gene

Genes around COG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COG3 Gene

Proteins for COG3 Gene

  • Protein details for COG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Conserved oligomeric Golgi complex subunit 3
    Protein Accession:
    Secondary Accessions:
    • B2RAW5
    • Q5VT70
    • Q8IXX4
    • Q9BZ92

    Protein attributes for COG3 Gene

    828 amino acids
    Molecular mass:
    94096 Da
    Quaternary structure:
    • Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Interacts with TMEM115.

    Alternative splice isoforms for COG3 Gene


neXtProt entry for COG3 Gene

Proteomics data for COG3 Gene at MOPED

Post-translational modifications for COG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COG3 Gene

No data available for DME Specific Peptides for COG3 Gene

Domains & Families for COG3 Gene

Gene Families for COG3 Gene

Protein Domains for COG3 Gene


Suggested Antigen Peptide Sequences for COG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the COG3 family.
  • Belongs to the COG3 family.
genes like me logo Genes that share domains with COG3: view

Function for COG3 Gene

Molecular function for COG3 Gene

UniProtKB/Swiss-Prot Function:
Involved in ER-Golgi transport.
genes like me logo Genes that share phenotypes with COG3: view

Animal Models for COG3 Gene

MGI Knock Outs for COG3:
  • Cog3 tm1b(EUCOMM)Hmgu

Animal Model Products

miRNA for COG3 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COG3 Gene

Localization for COG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COG3 Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with the peripheral membrane of cis/medial cisternae.

Subcellular locations from

Jensen Localization Image for COG3 Gene COMPARTMENTS Subcellular localization image for COG3 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
GO:0032588 trans-Golgi network membrane TAS --
genes like me logo Genes that share ontologies with COG3: view

Pathways & Interactions for COG3 Gene

genes like me logo Genes that share pathways with COG3: view

Gene Ontology (GO) - Biological Process for COG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 20163571
GO:0033365 protein localization to organelle IMP 16420527
genes like me logo Genes that share ontologies with COG3: view

No data available for SIGNOR curated interactions for COG3 Gene

Drugs & Compounds for COG3 Gene

No Compound Related Data Available

Transcripts for COG3 Gene

Unigene Clusters for COG3 Gene

Component of oligomeric golgi complex 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COG3 Gene

No ASD Table

Relevant External Links for COG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COG3 Gene

mRNA expression in normal human tissues for COG3 Gene

Protein differential expression in normal tissues from HIPED for COG3 Gene

This gene is overexpressed in Bone (59.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COG3 Gene

SOURCE GeneReport for Unigene cluster for COG3 Gene Hs.507948

mRNA Expression by UniProt/SwissProt for COG3 Gene

Tissue specificity: Widely expressed with highest levels in pancreas and testis and lowest levels in lung.
genes like me logo Genes that share expression patterns with COG3: view

Protein tissue co-expression partners for COG3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COG3 Gene

Orthologs for COG3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COG3 35
  • 92.07 (n)
  • 95.65 (a)
COG3 36
  • 92 (a)
(Canis familiaris)
Mammalia COG3 35
  • 93 (n)
  • 95.29 (a)
COG3 36
  • 92 (a)
(Mus musculus)
Mammalia Cog3 35
  • 90.04 (n)
  • 95.94 (a)
Cog3 16
Cog3 36
  • 96 (a)
(Pan troglodytes)
Mammalia COG3 35
  • 99.52 (n)
  • 100 (a)
COG3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cog3 35
  • 89.91 (n)
  • 96.43 (a)
(Monodelphis domestica)
Mammalia COG3 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia COG3 36
  • 89 (a)
(Gallus gallus)
Aves COG3 35
  • 81.22 (n)
  • 88.44 (a)
COG3 36
  • 88 (a)
(Anolis carolinensis)
Reptilia COG3 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cog3 35
  • 76.92 (n)
  • 83.27 (a)
Str.1471 35
(Danio rerio)
Actinopterygii cog3 35
  • 70.93 (n)
  • 78.76 (a)
cog3 36
  • 78 (a)
cog3 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3248 37
  • 42 (a)
Cog3 35
  • 51.07 (n)
  • 46.15 (a)
Cog3 36
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003970 35
  • 51.73 (n)
  • 46.92 (a)
(Caenorhabditis elegans)
Secernentea cogc-3 35
  • 48.33 (n)
  • 35.16 (a)
cogc-3 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COG3 36
  • 20 (a)
COG3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73430 35
  • 48.57 (n)
  • 39.02 (a)
(Oryza sativa)
Liliopsida Os.24582 35
Os08g0451000 35
  • 48.57 (n)
  • 38.23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12103 35
Species with no ortholog for COG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COG3 Gene

Gene Tree for COG3 (if available)
Gene Tree for COG3 (if available)

Paralogs for COG3 Gene

No data available for Paralogs for COG3 Gene

Variants for COG3 Gene

Sequence variations from dbSNP and Humsavar for COG3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_036454 A breast cancer sample
rs2274285 - 45,529,800(+) GGTCA(A/G)TGACC nc-transcript-variant, reference, missense
rs942890 -- 45,467,755(-) AAAGA(A/G)TAGTA intron-variant
rs942891 -- 45,517,987(-) TTTCT(A/G)TAAGA intron-variant
rs999252 -- 45,522,726(+) GTAAT(A/G)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COG3 Gene

Variant ID Type Subtype PubMed ID
dgv250e201 CNV Deletion 23290073
nsv455875 CNV Loss 19166990
nsv510583 CNV Loss 20534489
esv1166784 CNV Deletion 17803354
esv1140090 CNV Deletion 17803354
esv271929 CNV Insertion 20981092

Variation tolerance for COG3 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COG3 Gene

Disorders for COG3 Gene

Relevant External Links for COG3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COG3 Gene

Publications for COG3 Gene

  1. TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport. (PMID: 24806965) Ong Y.S. … Hong W. (J. Cell Sci. 2014) 3 4 67
  2. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PMID: 11980916) Ungar D. … Waters M.G. (J. Cell Biol. 2002) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for COG3 Gene

Sources for COG3 Gene