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COG3 Gene

protein-coding   GIFtS: 53
GCID: GC13P046039

Component Of Oligomeric Golgi Complex 3

  Search for COG3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Component Of Oligomeric Golgi Complex 31 2 3     p942 3
SEC342 3 5     Conserved Oligomeric Golgi Complex Subunit 32
Vesicle-Docking Protein SEC34 Homolog2 3     Tethering Factor SEC342
COG Complex Subunit 32 3     

External Ids:    HGNC: 186191   Entrez Gene: 835482   Ensembl: ENSG000001361527   OMIM: 6069755   UniProtKB: Q96JB23   

Export aliases for COG3 gene to outside databases

Previous GC identifers: GC13P044039 GC13P040026 GC13P044975 GC13P043837 GC13P044937 GC13P026835


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COG3 Gene:
This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different
subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in
multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi
transport.(provided by RefSeq, Jun 2011)

GeneCards Summary for COG3 Gene:
COG3 (component of oligomeric golgi complex 3) is a protein-coding gene. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot: COG3_HUMAN, Q96JB2
Function: Involved in ER-Golgi transport

Gene Wiki entry for COG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COG3 gene promoter:
         GCNF   NF-AT   c-Rel   NF-AT4   NF-AT2   GCNF-1   NF-AT3   Pax-4a   GCNF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOG3 promoter sequence
   Search Chromatin IP Primers for COG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.13   Ensembl cytogenetic band:  13q14.13   HGNC cytogenetic band: 13q14.11

COG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COG3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P046039:  view genomic region     (about GC identifiers)

Start:
46,039,030 bp from pter      End:
46,110,833 bp from pter
Size:
71,804 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COG3_HUMAN, Q96JB2 (See protein sequence)
Recommended Name: Conserved oligomeric Golgi complex subunit 3  
Size: 828 amino acids; 94096 Da
Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is
required for normal Golgi morphology and localization (By similarity)
Secondary accessions: B2RAW5 Q5VT70 Q8IXX4 Q9BZ92
Alternative splicing: 2 isoforms:  Q96JB2-1   Q96JB2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COG3: NX_Q96JB2

Explore proteomics data for COG3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_113619.2  
    ENSEMBL proteins: 
     ENSP00000258654  

    COG3 Human Recombinant Protein Products:

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    Novus Biologicals COG3 Proteins
    Novus Biologicals COG3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for COG3

     
    Search eBioscience for Proteins for COG3 

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    LSBio Antibodies in human, mouse, rat for COG3

    COG3 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for COG3
    Cloud-Clone Corp. CLIAs for COG3
    Search eBioscience for ELISAs for COG3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COG: Components of oligomeric golgi complex

    1 InterPro protein domain:
     IPR007265 COG_su3

    Graphical View of Domain Structure for InterPro Entry Q96JB2

    ProtoNet protein and cluster: Q96JB2

    1 Blocks protein domain: IPB007265 Sec34-like protein

    UniProtKB/Swiss-Prot: COG3_HUMAN, Q96JB2
    Similarity: Belongs to the COG3 family


    Find genes that share domains with COG3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COG3_HUMAN, Q96JB2
    Function: Involved in ER-Golgi transport

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19536132
    GO:0008565protein transporter activity IDA11929878
         
    Find genes that share ontologies with COG3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for COG3:
     Decreased p24 protein expressi  Decreased viability of wild-ty 

         1 MGI phenotypic allele for Cog3 (no phenotypes)

    Find genes that share phenotypes with COG3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COG3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COG3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COG3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COG3

    miRNA
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    miRTarBase miRNAs that target COG3:
    hsa-mir-335-5p (MIRT017229)

    Block miRNA regulation of human, mouse, rat COG3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COG3 (see all 52):
    hsa-miR-142-5p hsa-miR-25 hsa-let-7a-2* hsa-miR-374a hsa-miR-548l hsa-miR-374c hsa-miR-9 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidCOG3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COG3
    Predesigned siRNA for gene silencing in human, mouse, rat COG3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): COG3 (NM_031431)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COG3_HUMAN, Q96JB2: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with the
    peripheral membrane of cis/medial cisternae
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus4
    plasma membrane4
    cytosol3
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005801cis-Golgi network IEA--

    Find genes that share ontologies with COG3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COG3
    Interactions:

        GeneGlobe Interaction Network for COG3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COG3 (Q96JB22, 3 ENSP000002586544) via UniProtKB, MINT, STRING, and/or I2D (see all 137)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000236014Q8N1B43, ENSP000004069884I2D: score=4 STRING: ENSP00000406988
    VPS52Q8N1B43, ENSP000004099524I2D: score=4 STRING: ENSP00000409952
    ENSG00000206286Q8N1B43I2D: score=4 
    ENSG00000224455Q8N1B43I2D: score=4 
    ENSG00000225590Q8N1B43I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IMP16420527
    GO:0006886intracellular protein transport IEA--
    GO:0006888ER to Golgi vesicle-mediated transport IDA11929878
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER IMP16420527
    GO:0006891intra-Golgi vesicle-mediated transport IDA11929878

    Find genes that share ontologies with COG3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COG3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COG3 gene (2 alternative transcripts): 
    NM_031431.3  NM_001204476.1  

    Unigene Cluster for COG3:

    Component of oligomeric golgi complex 3
    Hs.507948  [show with all ESTs]
    Unigene Representative Sequence: NM_031431
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000349995(uc010tfu.2 uc001vai.3 uc001vak.3 uc010tfv.2 uc010aci.3)
    ENST00000476702 ENST00000465942 ENST00000486940
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COG3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COG3 (see all 52):
    hsa-miR-142-5p hsa-miR-25 hsa-let-7a-2* hsa-miR-374a hsa-miR-548l hsa-miR-374c hsa-miR-9 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidCOG3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COG3
    Predesigned siRNA for gene silencing in human, mouse, rat COG3
    Clone
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    OriGene clones in human, mouse for COG3 (see all 8)
    OriGene ORF clones in mouse, rat for COG3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): COG3 (NM_031431)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for COG3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COG3
      QuantiTect SYBR Green Assays in human, mouse, rat COG3
      QuantiFast Probe-based Assays in human, mouse, rat COG3

    Additional mRNA sequence: 

    AF111707.1 AF131829.1 AF332595.1 AF349676.1 AK026305.1 AK026994.1 AK057884.1 AK074374.1 
    AK225466.1 AK225952.1 AK294959.1 AK304248.1 AK314387.1 BC038953.1 BX648211.1 

    15 DOTS entries:

    DT.317524  DT.317523  DT.120781255  DT.91756988  DT.75195575  DT.100733653  DT.40120867  DT.100806237 
    DT.100776939  DT.120781238  DT.100681195  DT.102821681  DT.120781254  DT.91806579  DT.97824744 

    Selected AceView cDNA sequences (see all 162):

    CR609778 BP356199 T34468 Z40695 AI249761 AK026305 AW075868 AA404461 
    AI042599 CD108885 AI141864 AI683466 BP356228 CA418431 BQ722113 AA243717 
    AA501982 BQ573703 H57063 BQ718157 AW103697 AW517527 W02347 N39675 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATTGTAC
    COG3 Expression
    About this image

    COG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COG3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507948

    UniProtKB/Swiss-Prot: COG3_HUMAN, Q96JB2
    Tissue specificity: Widely expressed with highest levels in pancreas and testis and lowest levels in lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COG3 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cog31 , 5 component of oligomeric golgi complex 31, 5 90.04(n)1
    95.94(a)1
      14 (40.29 cM)5
    3383371  NM_177381.31  NP_796355.21 
     757023515 
    chicken
    (Gallus gallus)
    Aves COG31 component of oligomeric golgi complex 3 81.22(n)
    88.44(a)
      418846  XM_417041.4  XP_417041.3 
    lizard
    (Anolis carolinensis)
    Reptilia COG36
    component of oligomeric golgi complex 3
    82(a)
    1 ↔ 1
    GL343297.1(1326734-1359275)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.14712 Transcribed sequence with moderate similarity to protein more 78.36(n)    AL849795.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cog31 component of oligomeric golgi complex 3 70.93(n)
    78.76(a)
      553061  NM_001144040.1  NP_001137512.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32483
    Cog31
    Cog31 42(a)3
    51.07(n)1
    46.15(a)1
      23F33
    335621  NM_134935.21  NP_608779.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cogc-31 cogc-3 48.33(n)
    35.16(a)
      171867  NM_001026635.2  NP_001021806.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COG3(YER157W)4 Essential component of the conserved oligomeric Golgi more   --   5(484788-487193) 856901  NP_011084.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G734301 AT1G73430 48.57(n)
    39.02(a)
      843677  NM_106002.3  NP_177485.2 
    rice
    (Oryza sativa)
    Liliopsida Os.245822 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.44(n)    AK067199.1 


    ENSEMBL Gene Tree for COG3 (if available)
    TreeFam Gene Tree for COG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COG3 (see all 1468)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364544
    A breast cancer sample4--see VAR_0364542 R C mis40--------
    rs1852078411,2
    --26833823(+) TCTTCA/GTGTTG 1 -- us2k10--------
    rs1471999931,2
    --26833850(+) TTTCCA/GGCAAA 1 -- us2k10--------
    rs1882119781,2
    --26834056(+) CAGATG/TTTTTA 1 -- us2k10--------
    rs1405918591,2
    --26834109(+) AAAGGA/GTGTCA 1 -- us2k10--------
    rs1445564191,2
    --26834154(+) GCTGAA/TGTTAA 1 -- us2k10--------
    rs128664731,2
    C,F,H--26834196(+) TTCACC/TTCTAC 1 -- us2k113Minor allele frequency- T:0.03NS EA NA 1652
    rs1474559731,2
    C--26834334(+) GTGCAA/GTGGTG 1 -- us2k10--------
    rs1817891131,2
    C--26834369(+) GCCTCC/GTGGGT 1 -- us2k10--------
    rs1485083811,2
    --26834508(+) ACTCCC/TGACCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COG3 (46039030 - 46110833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for COG3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1140090CNV Deletion17803354
    esv1166784CNV Deletion17803354
    dgv250e201CNV Deletion23290073
    esv271929CNV Insertion20981092
    nsv510583CNV Loss20534489
    nsv455875CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COG3
    DNA2.0 Custom Variant and Variant Library Synthesis for COG3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606975    OMIM disorders: --


    Find genes that share disorders with COG3           About GenesLikeMe

    Genetic Association Database (GAD): COG3
    Human Genome Epidemiology (HuGE) Navigator: COG3 (1 document)

    Export disorders for COG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COG3 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with COG3)
        Utopia: connect your pdf to the dynamic
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    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    4. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PubMed id 11980916)1, 3 Ungar D.... Waters M.G. (J. Cell Biol. 2002)
    5. Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. (PubMed id 11929878)1, 2 Loh E. and Hong W. (J. Biol. Chem. 2002)
    6. Identification of a human ortholog of Sec34p as a component of the cis-Golgi vesicle tethering machinery. (PubMed id 11292827)1, 2 Suvorova E.S.... Lupashin V.V. (J. Biol. Chem. 2001)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83548 HGNC: 18619 AceView: COG3 Ensembl:ENSG00000136152 euGenes: HUgn83548
    ECgene: COG3 H-InvDB: COG3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COG3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COG3 gene:
    Search GeneIP for patents involving COG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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