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Aliases for COG2 Gene

Aliases for COG2 Gene

  • Component Of Oligomeric Golgi Complex 2 2 3 4 5
  • Low Density Lipoprotein Receptor Defect C-Complementing Protein 3 4
  • Low Density Lipoprotein Receptor Defect C Complementing 2 3
  • COG Complex Subunit 2 3 4
  • LDLC 3 4
  • Brefeldin A-Sensitive, Peripheral Golgi Protein 3
  • Conserved Oligomeric Golgi Complex Protein 2 3

External Ids for COG2 Gene

Previous HGNC Symbols for COG2 Gene

  • LDLC

Previous GeneCards Identifiers for COG2 Gene

  • GC01P229255
  • GC01P226506
  • GC01P227251
  • GC01P227813
  • GC01P227084
  • GC01P228844
  • GC01P230778
  • GC01P201264

Summaries for COG2 Gene

Entrez Gene Summary for COG2 Gene

  • This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for COG2 Gene

COG2 (Component Of Oligomeric Golgi Complex 2) is a Protein Coding gene. Diseases associated with COG2 include Cog2-Cdg and Lipid Metabolism Disorder. Among its related pathways are Transport to the Golgi and subsequent modification and Golgi-to-ER retrograde transport. GO annotations related to this gene include protein complex binding and protein transporter activity.

UniProtKB/Swiss-Prot for COG2 Gene

  • Required for normal Golgi morphology and function.

Gene Wiki entry for COG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COG2 Gene

Genomics for COG2 Gene

Regulatory Elements for COG2 Gene

Enhancers for COG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COG2 on UCSC Golden Path with GeneCards custom track

Promoters for COG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for COG2 Gene

230,642,456 bp from pter
230,693,985 bp from pter
51,530 bases
Plus strand

Genomic View for COG2 Gene

Genes around COG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COG2 Gene

Proteins for COG2 Gene

  • Protein details for COG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Conserved oligomeric Golgi complex subunit 2
    Protein Accession:
    Secondary Accessions:
    • Q86U99

    Protein attributes for COG2 Gene

    738 amino acids
    Molecular mass:
    83208 Da
    Quaternary structure:
    • Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

    Alternative splice isoforms for COG2 Gene


neXtProt entry for COG2 Gene

Proteomics data for COG2 Gene at MOPED

Post-translational modifications for COG2 Gene

  • Ubiquitination at Lys 54, Lys 188, Lys 584, and Lys 717
  • Modification sites at PhosphoSitePlus

Other Protein References for COG2 Gene

No data available for DME Specific Peptides for COG2 Gene

Domains & Families for COG2 Gene

Gene Families for COG2 Gene

Protein Domains for COG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the COG2 family.
  • Belongs to the COG2 family.
genes like me logo Genes that share domains with COG2: view

Function for COG2 Gene

Molecular function for COG2 Gene

UniProtKB/Swiss-Prot Function:
Required for normal Golgi morphology and function.
genes like me logo Genes that share phenotypes with COG2: view

Animal Models for COG2 Gene

MGI Knock Outs for COG2:
  • Cog2 tm1a(KOMP)Wtsi

Animal Model Products

miRNA for COG2 Gene

miRTarBase miRNAs that target COG2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COG2 Gene

Localization for COG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COG2 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for COG2 Gene COMPARTMENTS Subcellular localization image for COG2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
extracellular 4
nucleus 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for COG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005795 Golgi stack IDA 7962052
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with COG2: view

Pathways & Interactions for COG2 Gene

genes like me logo Genes that share pathways with COG2: view

Gene Ontology (GO) - Biological Process for COG2 Gene


No data available for SIGNOR curated interactions for COG2 Gene

Drugs & Compounds for COG2 Gene

(47) Drugs for COG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(18) Additional Compounds for COG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with COG2: view

Transcripts for COG2 Gene

Unigene Clusters for COG2 Gene

Component of oligomeric golgi complex 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COG2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^
SP1: - - - - - -
SP2: - - - - - -

ExUns: 22

Relevant External Links for COG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COG2 Gene

mRNA expression in normal human tissues for COG2 Gene

Protein differential expression in normal tissues from HIPED for COG2 Gene

This gene is overexpressed in Bone (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COG2 Gene

SOURCE GeneReport for Unigene cluster for COG2 Gene Hs.211800

genes like me logo Genes that share expression patterns with COG2: view

Protein tissue co-expression partners for COG2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COG2 Gene

Orthologs for COG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COG2 35
  • 87.13 (n)
  • 89.7 (a)
COG2 36
  • 89 (a)
(Canis familiaris)
Mammalia COG2 35
  • 89.59 (n)
  • 92.3 (a)
cfa-mir-1841 36
  • 91 (a)
(Mus musculus)
Mammalia Cog2 35
  • 81.19 (n)
  • 86.3 (a)
Cog2 16
Cog2 36
  • 85 (a)
(Pan troglodytes)
Mammalia COG2 35
  • 99.5 (n)
  • 99.59 (a)
COG2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cog2 35
  • 80.96 (n)
  • 85.75 (a)
(Monodelphis domestica)
Mammalia COG2 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia COG2 36
  • 74 (a)
(Gallus gallus)
Aves COG2 35
  • 77.66 (n)
  • 80.05 (a)
COG2 36
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
-- 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cog2 35
  • 69.21 (n)
  • 70.71 (a)
Str.11116 35
(Danio rerio)
Actinopterygii cog2 35
  • 65.79 (n)
  • 70.21 (a)
wufj87b02 35
cog2 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4936 35
fruit fly
(Drosophila melanogaster)
Insecta ldlCp 37
  • 32 (a)
ldlCp 35
  • 45.46 (n)
  • 36.39 (a)
ldlCp 36
  • 34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003824 35
  • 45.35 (n)
  • 35.3 (a)
(Caenorhabditis elegans)
Secernentea cogc-2 35
  • 39.37 (n)
  • 27.57 (a)
cogc-2 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24840 35
  • 43.55 (n)
  • 31.94 (a)
(Oryza sativa)
Liliopsida Os03g0849600 35
  • 42.73 (n)
  • 30.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for COG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COG2 Gene

Gene Tree for COG2 (if available)
Gene Tree for COG2 (if available)

Paralogs for COG2 Gene

No data available for Paralogs for COG2 Gene

Variants for COG2 Gene

Sequence variations from dbSNP and Humsavar for COG2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6681346 - 230,675,010(+) GGCAA(A/T)ACTGT reference, missense
rs34796217 - 230,671,604(+) TTGCC(A/G)CCTTC reference, missense
rs34109129 - 230,688,533(+) TGGAG(A/G)TTCCC reference, missense
rs1007456 -- 230,685,827(-) AGGTC(C/T)CAGCA intron-variant
rs943579 -- 230,679,630(+) TTTCA(C/T)GATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COG2 Gene

Variant ID Type Subtype PubMed ID
nsv524949 CNV Loss 19592680
nsv832836 CNV Loss 17160897

Variation tolerance for COG2 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COG2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COG2 Gene

Disorders for COG2 Gene

MalaCards: The human disease database

(25) MalaCards diseases for COG2 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • cog2-related congenital disorder of glycosylation
lipid metabolism disorder
  • dyslipidemia
coronary artery disease
  • chronic myocardial ischemia
hypercholesterolemia, familial
  • hypercholesterolemia, familial, modifier of
  • arteriosclerosis nos
- elite association - COSMIC cancer census association via MalaCards
Search COG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for COG2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with COG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COG2 Gene

Publications for COG2 Gene

  1. LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function. (PMID: 7962052) Podos S.D. … Krieger M. (J. Cell Biol. 1994) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for COG2 Gene

Sources for COG2 Gene