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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COG2 Gene

protein-coding   GIFtS: 54
GCID: GC01P230778

component of oligomeric golgi complex 2

(Previous name: low density lipoprotein receptor defect C complementing...)
(Previous symbol: LDLC)
 Explore 67 diseases affiliated with
COG2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for COG2    

Aliases
for COG2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Component Of Oligomeric Golgi Complex 21 2 3     COG Complex Subunit 22 3
LDLC1 2 3 5     Brefeldin A-Sensitive, Peripheral Golgi Protein2
Low Density Lipoprotein Receptor Defect C Complementing1 2     Conserved Oligomeric Golgi Complex Protein 22
Low Density Lipoprotein Receptor Defect C-Complementing Protein2 3     Conserved Oligomeric Golgi Complex Subunit 22

External Ids:    HGNC: 65461   Entrez Gene: 227962   Ensembl: ENSG000001357757   OMIM: 6069745   UniProtKB: Q147463   

Export aliases for COG2 gene to outside databases

Previous GC identifers: GC01P229255 GC01P226506 GC01P227251 GC01P227813 GC01P227084 GC01P228844 GC01P201264


Summaries
for COG2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for COG2:
This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure
and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein
and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are
associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript
variants.(provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: COG2_HUMAN, Q14746
Function: Required for normal Golgi morphology and function

Gene Wiki entry for COG2


Genomic Views
for COG2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COG2 gene promoter:
         NF-kappaB   RORalpha2   PPAR-gamma1   NF-AT4   NF-AT2   NF-AT3   PPAR-gamma2   NF-Y   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for COG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.2   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

COG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COG2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P230778:  view genomic region     (about GC identifiers)

Start:
 230,778,202 bp from pter      End:
 230,829,731 bp from pter
Size:
 51,530 bases      Orientation:
 plus strand

Proteins
for COG2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: COG2_HUMAN, Q14746 (See protein sequence)
Recommended Name: Conserved oligomeric Golgi complex subunit 2  
Size: 738 amino acids; 83208 Da
Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is
required for normal Golgi morphology and localization
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (Probable)
Secondary accessions: Q86U99
Alternative splicing: 2 isoforms:  Q14746-1   Q14746-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COG2: NX_Q14746

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14746

    • COG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138508.1  NP_031383.1  

    ENSEMBL proteins: 
     ENSP00000355629   ENSP00000355628   ENSP00000440349   ENSP00000445724   ENSP00000442147  

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    Novus Biologicals COG2 Protein
    Novus Biologicals COG2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for COG2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005795Golgi stack IDA7962052
    GO:0016020membrane ----
    GO:0017119Golgi transport complex IMP7962052


    COG2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for COG2

    Protein Domains /
    Families
    for COG2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    COG2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR024603 COG_complex_COG2_C
     IPR009316 COG2
     IPR024602 COG_su2_N

    Graphical View of Domain Structure for InterPro Entry Q14746

    ProtoNet protein and cluster: Q14746

    1 Blocks protein family: IPB009316 COG complex component

    UniProtKB/Swiss-Prot: COG2_HUMAN, Q14746
    Similarity: Belongs to the COG2 family


    Function
    for COG2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: COG2_HUMAN, Q14746
    Function: Required for normal Golgi morphology and function

    miRNA
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    hsa-miR-3163 hsa-miR-3607-3p hsa-miR-607 hsa-miR-548am hsa-miR-3688-3p hsa-miR-625* hsa-miR-411 hsa-miR-561
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for COG2

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15047703
    GO:0008565protein transporter activity IMP7962052


    COG2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for COG2:
     Decreased p24 protein expressi  Decreased viability with pacli 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cog2):
     mortality/aging 

    COG2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for COG2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/15 Interacting proteins for COG2 (Q147461, 3 ENSP000003556294) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COG4Q9H9E31, 3, ENSP000003157754EBI-389449,EBI-368382 I2D: score=3 STRING: ENSP00000315775
    COG3Q96JB23, ENSP000002586544I2D: score=1 STRING: ENSP00000258654
    RRM1P239213I2D: score=2 
    TRAF2Q129333I2D: score=1 
    COG1ENSP000002998864STRING: ENSP00000299886
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation TAS7962052
    GO:0006886intracellular protein transport TAS7962052
    GO:0006891intra-Golgi vesicle-mediated transport IMP7962052
    GO:0007030Golgi organization IMP7962052
    GO:0009312oligosaccharide biosynthetic process TAS7962052


    COG2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for COG2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    COG2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COG2
    10/65 Novoseek chemical compound relationships for COG2 gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 89.7 1226 1402403 (7), 15161326 (6), 19273753 (5), 7992364 (5) (see all 99)
    atorvastatin 81.1 146 15389231 (6), 11376309 (5), 18635754 (5), 12145769 (5) (see all 43)
    ezetimibe 81 73 15324522 (5), 16971979 (4), 11558859 (4), 17451281 (4) (see all 26)
    rosuvastatin 80.9 108 17996658 (6), 14745143 (6), 18158079 (4), 18196620 (4) (see all 24)
    lipid 80.1 152 19891279 (4), 18834233 (4), 12572624 (3), 18783300 (3) (see all 97)
    simvastatin 79.8 100 11191012 (5), 11293560 (5), 7614520 (4), 10566573 (4) (see all 43)
    fluvastatin 78.1 40 8017467 (4), 14693301 (4), 19328972 (3), 18343245 (2) (see all 21)
    pravastatin 73.7 43 7573090 (3), 11873095 (3), 14745143 (3), 11594407 (3) (see all 24)
    cholestyramine 67.9 12 15639697 (3), 19496269 (1), 7573090 (1), 8729587 (1) (see all 8)
    niacin 64.3 25 19678716 (2), 12793597 (1), 17853726 (1), 19702110 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about COG2 

    Transcripts
    for COG2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for COG2 gene (2 alternative transcripts): 
    NM_001145036.1  NM_007357.2  

    Unigene Cluster for COG2:

    Component of oligomeric golgi complex 2
    Hs.211800  [show with all ESTs]
    Unigene Representative Sequence: NM_007357
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494371 ENST00000366669(uc001htw.3 uc001htx.3 uc010pwc.2)
    ENST00000473671 ENST00000366668 ENST00000468893 ENST00000482012 ENST00000490900
    ENST00000478710 ENST00000534989 ENST00000535166 ENST00000546013

    miRNA
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    hsa-miR-3163 hsa-miR-3607-3p hsa-miR-607 hsa-miR-548am hsa-miR-3688-3p hsa-miR-625* hsa-miR-411 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmid: COG2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COG2 (see all 7)
    OriGene shRNA RFP: COG2
    OriGene siRNA: COG2
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK295251.1 AK302288.1 AK312678.1 BC014960.1 BC051906.1 S77362.1 Z34975.1 

    10 DOTS entries:

    DT.316057  DT.316058  DT.121399389  DT.100778663  DT.408626  DT.97842631  DT.75109492  DT.40234203 
    DT.40295055  DT.95367489 

    24/208 AceView cDNA sequences (see all 208):

    AA280935 BE550232 BF513609 AA236106 BP358221 BX483504 BM917756 CB128739 
    BC014960 BG055022 AA385035 BU616835 AI804928 BX116392 AA832272 AA644202 
    BF002124 BG740167 AU124934 BQ687532 AU133010 BM797925 BU729559 AU131150 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for COG2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^
    SP1:                                -                                               -     -           -                                   -                 -   
    SP2:                                -                                               -     -           -                                   -                 -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for COG2

    Expression
    for COG2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGTCTTCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See COG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COG2

    SOURCE GeneReport for Unigene cluster: Hs.211800
        SABiosciences Custom PCR Arrays for COG2
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    In Situ
    Assay Products:     
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    Orthologs
    for COG2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COG2 gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cog21 , 5 component of oligomeric golgi complex 21, 5 81.19(n)1
    86.3(a)1    		   8 (72.78 cM)5
    763321  NM_029746.31  NP_084022.21 
     1245207675 
    chicken
    (Gallus gallus)    		 Aves COG21 component of oligomeric golgi complex 2 77.66(n)
    80.05(a)    		   421542  XM_419583.3  XP_419583.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 86(a)
    74(a)
    		 many → 1
    many → 1
    		 GL344499.1(5174-19729)
    1(222808771-222824789)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.111162 Transcribed sequence with moderate similarity to protein more 78.05(n)    AL856741.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj87b022 Danio rerio mRNA similar to component of oligomeric more 73.67(n)    BC049314.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ldlCp1 , 3 exocytosis3
    ldlCp-related protein1    		 32(a)3
    45.5(n)1
    35.59(a)1    		   88F13
    418701  NM_079642.21  NP_524366.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea cogc-21 Protein COGC-2 41.74(n)
    27.68(a)    		   177473  NM_068691.4  NP_501092.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G248401 hypothetical protein 43.5(n)
    31.94(a)    		   828587  NM_118617.4  NP_567710.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g08496001 hypothetical protein 42.77(n)
    30.66(a)    		   4334786  NM_001058433.1  NP_001051898.1 


    ENSEMBL Gene Tree for COG2 (if available)
    TreeFam Gene Tree for COG2 (if available) 

    Paralogs
    for COG2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for COG2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/991 NCBI SNPs in COG2 are shown (see all 991)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs38383041,2
    		C--201313486(+) TTGTT-/ATTGTCGT 1 -- int11Minor allele frequency- ATT:0.00NA 2
    rs101583101,2
    		C,F,--230776264(+) AAAATG/ATCAGG 2 -- us2k15Minor allele frequency- A:0.16NA WA EA 362
    rs1874961401,2
    		--230776272(+) AGGGTC/TTTTTT 2 -- us2k10--------
    rs731162441,2
    		C,F,--230776292(+) NNNNGC/TGTAAA 2 -- us2k12Minor allele frequency- T:0.09WA NA 238
    rs1924918531,2
    		--230776293(+) GATGCA/GTAAAC 2 -- us2k10--------
    rs790224131,2
    		C,--230776381(+) AGTGGT/CTNNNN 2 -- us2k13Minor allele frequency- C:0.10WA NA 240
    rs1858093251,2
    		--230776425(+) GGTGGA/GTCATC 2 -- us2k10--------
    rs1115584521,2
    		C,--230776434(+) TCTGAG/AGTCAG 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs43991681,2
    		C,A,--230776438(+) AGGTCG/AGGGGT 2 -- us2k1 tfbs35Minor allele frequency- A:0.10NA WA 10
    rs1927508821,2
    		--230776545(+) GGGAGG/TCTGAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for COG2 (230778202 - 230829731 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for COG2: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for COG2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    COG2 for disorders           About GeneDecksing

    OMIM gene information: 606974    OMIM disorders: --

    20/67 diseases for COG2 (see all 67):    About MalaCards
    hyperlipoproteinemia type iii    spinal cord injury    arcus senilis    high blood pressure
    focal segmental glomerulosclerosis    glucose intolerance    carotid artery thrombosis    alcohol abuse
    hyperlipoproteinemia    type 2 diabetes mellitus    coronary heart disease    myocardial infarction
    hyperlipidemia    carotid artery disease    carotid stenosis    cerebrovascular accident
    diabetes mellitus    insulin resistance    hypercholesterolemia    ischemic heart disease

    8 diseases from the University of Copenhagen DISEASES database for COG2:
    Coronary heart disease     Atherosclerosis     Diabetes mellitus     Familial hyperlipidemia
    Hypertension     Myocardial infarction     Cerebrovascular accident     Arcus senilis

    10/48 Novoseek disease relationships for COG2 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypercholesterolemia 79.5 57 19678716 (2), 7573090 (2), 17036098 (2), 16404837 (2) (see all 39)
    hypercholesterolemia familial 76.7 15 1959928 (2), 1415054 (2), 1770303 (1), 20506408 (1) (see all 13)
    coronary heart disease 76.7 47 8105786 (1), 11191012 (1), 12023827 (1), 16522931 (1) (see all 37)
    dyslipidemia 75.8 31 11376309 (2), 17847038 (2), 11849617 (1), 8696067 (1) (see all 18)
    hyperlipidemia 63 7 12839659 (2), 10998478 (2), 18257145 (1), 19328972 (1) (see all 5)
    cardiovascular diseases 62.4 11 16185099 (1), 15177127 (1), 17636341 (1), 17996658 (1) (see all 11)
    coronary artery disease 60.4 18 7604802 (2), 11374858 (1), 8017467 (1), 16608374 (1) (see all 15)
    atherosclerosis 59 26 14745143 (2), 19702110 (2), 10365572 (1), 16415542 (1) (see all 22)
    combined hyperlipidemia 58.5 1 14728015 (1)
    niddm 55.2 12 7573090 (2), 19465013 (1), 15040041 (1), 19344229 (1) (see all 8)

    Human Genome Epidemiology (HuGE) Navigator: COG2 (4 documents)

    Export disorders for COG2 gene to outside databases

    Publications
    for COG2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COG2 gene, integrated from 9 sources (see all 508):
    (articles sorted by number of sources associating them with COG2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function. (PubMed id 7962052)1, 2, 3 Podos S.D.... Krieger M. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1 Luke M.M....Psaty B.M. (2009)

    External Searches for COG2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing COG2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22796 HGNC: 6546 AceView: COG2 Ensembl:ENSG00000135775 euGenes: HUgn22796
    ECgene: COG2 H-InvDB: COG2

    Other Databases showing COG2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing COG2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COG2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for COG2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for COG2 gene:
    Search GeneIP for patents involving COG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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