Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



COG2 Gene

protein-coding   GIFtS: 58
GCID: GC01P230778

Component Of Oligomeric Golgi Complex 2

(Previous name: low density lipoprotein receptor defect C complementing)
(Previous symbol: LDLC)
  See COG2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Component Of Oligomeric Golgi Complex 21 2 3     COG Complex Subunit 22 3
LDLC1 2 3 5     Brefeldin A-Sensitive, Peripheral Golgi Protein2
Low Density Lipoprotein Receptor Defect C Complementing1 2     Conserved Oligomeric Golgi Complex Protein 22
Low Density Lipoprotein Receptor Defect C-Complementing Protein2 3     Conserved Oligomeric Golgi Complex Subunit 22

External Ids:    HGNC: 65461   Entrez Gene: 227962   Ensembl: ENSG000001357757   OMIM: 6069745   UniProtKB: Q147463   

Export aliases for COG2 gene to outside databases

Previous GC identifers: GC01P229255 GC01P226506 GC01P227251 GC01P227813 GC01P227084 GC01P228844 GC01P201264


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for COG2 Gene:
This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal
structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle
docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes.
Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative
splicing results in multiple transcript variants.(provided by RefSeq, Feb 2009)

GeneCards Summary for COG2 Gene:
COG2 (component of oligomeric golgi complex 2) is a protein-coding gene. Diseases associated with COG2 include carotid artery thrombosis, and hyperlipoproteinemia type iii. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot: COG2_HUMAN, Q14746
Function: Required for normal Golgi morphology and function

Gene Wiki entry for COG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COG2 gene promoter:
         NF-kappaB   RORalpha2   PPAR-gamma1   NF-AT4   NF-AT2   NF-AT3   PPAR-gamma2   NF-Y   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOG2 promoter sequence
   Search Chromatin IP Primers for COG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.2   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

COG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COG2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P230778:  view genomic region     (about GC identifiers)

Start:
230,778,202 bp from pter      End:
230,829,731 bp from pter
Size:
51,530 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: COG2_HUMAN, Q14746 (See protein sequence)
Recommended Name: Conserved oligomeric Golgi complex subunit 2  
Size: 738 amino acids; 83208 Da
Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is
required for normal Golgi morphology and localization
Secondary accessions: Q86U99
Alternative splicing: 2 isoforms:  Q14746-1   Q14746-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COG2: NX_Q14746

Explore proteomics data for COG2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys54, Lys188, Lys584, Lys717
  • Modification sites at PhosphoSitePlus

  • See COG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138508.1  NP_031383.1  

    ENSEMBL proteins: 
     ENSP00000355629   ENSP00000476305   ENSP00000355628   ENSP00000440349   ENSP00000445724  
     ENSP00000442147  

    COG2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for COG2
    OriGene Protein Over-expression Lysate for COG2
    OriGene MassSpec for COG2
    OriGene Custom Protein Services for COG2
    GenScript Custom Purified and Recombinant Proteins Services for COG2
    Novus Biologicals COG2 Protein
    Novus Biologicals COG2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COG2

     
    Search eBioscience for Proteins for COG2 

     
    antibodies-online proteins for COG2 (5 products) 

     
    antibodies-online peptides for COG2

    COG2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for COG2
    Novus Biologicals COG2 Antibodies
    Abcam antibodies for COG2
    Cloud-Clone Corp. Antibodies for COG2
    ThermoFisher Antibody for COG2
    antibodies-online antibodies for COG2 (23 products) 

    COG2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COG2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COG2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for COG2
    Cloud-Clone Corp. CLIAs for COG2
    Search eBioscience for ELISAs for COG2 
    antibodies-online kits for COG2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    COG: Components of oligomeric golgi complex

    3 InterPro protein domains:
     IPR024603 COG_complex_COG2_C
     IPR009316 COG2
     IPR024602 COG_su2_N

    Graphical View of Domain Structure for InterPro Entry Q14746

    ProtoNet protein and cluster: Q14746

    1 Blocks protein domain: IPB009316 COG complex component

    UniProtKB/Swiss-Prot: COG2_HUMAN, Q14746
    Similarity: Belongs to the COG2 family


    Find genes that share domains with COG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COG2_HUMAN, Q14746
    Function: Required for normal Golgi morphology and function

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15047703
    GO:0008565protein transporter activity IMP7962052
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with COG2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for COG2:
     Decreased p24 protein expressi  Decreased viability with pacli 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cog2):
     mortality/aging 

    Find genes that share phenotypes with COG2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for COG2

    miRNA
    Products:
        
    miRTarBase miRNAs that target COG2:
    hsa-mir-186-5p (MIRT045156), hsa-mir-155-5p (MIRT021018), hsa-mir-375 (MIRT020037)

    Block miRNA regulation of human, mouse, rat COG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COG2 (see all 15):
    hsa-miR-3163 hsa-miR-3607-3p hsa-miR-607 hsa-miR-548am hsa-miR-3688-3p hsa-miR-625* hsa-miR-411 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidCOG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COG2
    Predesigned siRNA for gene silencing in human, mouse, rat COG2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COG2

    Clone
    Products:
         
    OriGene clones in human, mouse for COG2 (see all 12)
    OriGene ORF clones in mouse, rat for COG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): COG2 (NM_001145036)
    Sino Biological Human cDNA Clone for COG2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COG2
    Browse ESI BIO Cell Lines and PureStem Progenitors for COG2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    COG2_HUMAN, Q14746: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular4
    cytosol2
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005795Golgi stack IDA7962052
    GO:0005829cytosol IEA--
    GO:0016020membrane ----
    GO:0017119Golgi transport complex IMP7962052

    Find genes that share ontologies with COG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COG2
    Interactions:

        GeneGlobe Interaction Network for COG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COG2 (Q147461, 3 ENSP000003556294) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COG4Q9H9E31, 3, ENSP000003157754EBI-389449,EBI-368382 I2D: score=3 STRING: ENSP00000315775
    COG3Q96JB23, ENSP000002586544I2D: score=1 STRING: ENSP00000258654
    RRM1P239213, ENSP000003007384I2D: score=2 STRING: ENSP00000300738
    TRAF2Q129333I2D: score=1 
    COG1ENSP000002998864STRING: ENSP00000299886
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation TAS7962052
    GO:0006886intracellular protein transport TAS7962052
    GO:0006891intra-Golgi vesicle-mediated transport IMP7962052
    GO:0007030Golgi organization IMP7962052
    GO:0009312oligosaccharide biosynthetic process TAS7962052

    Find genes that share ontologies with COG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COG2

    Selected Novoseek inferred chemical compound relationships for COG2 gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 89.7 1226 1402403 (7), 15161326 (6), 19273753 (5), 7992364 (5) (see all 99)
    atorvastatin 81.1 146 15389231 (6), 11376309 (5), 18635754 (5), 12145769 (5) (see all 43)
    ezetimibe 81 73 15324522 (5), 16971979 (4), 11558859 (4), 17451281 (4) (see all 26)
    rosuvastatin 80.9 108 17996658 (6), 14745143 (6), 18158079 (4), 18196620 (4) (see all 24)
    lipid 80.1 152 19891279 (4), 18834233 (4), 12572624 (3), 18783300 (3) (see all 97)
    simvastatin 79.8 100 11191012 (5), 11293560 (5), 7614520 (4), 10566573 (4) (see all 43)
    fluvastatin 78.1 40 8017467 (4), 14693301 (4), 19328972 (3), 18343245 (2) (see all 21)
    pravastatin 73.7 43 7573090 (3), 11873095 (3), 14745143 (3), 11594407 (3) (see all 24)
    cholestyramine 67.9 12 15639697 (3), 19496269 (1), 7573090 (1), 8729587 (1) (see all 8)
    niacin 64.3 25 19678716 (2), 12793597 (1), 17853726 (1), 19702110 (1) (see all 7)



    Find genes that share compounds with COG2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for COG2 gene (2 alternative transcripts): 
    NM_001145036.1  NM_007357.2  

    Unigene Cluster for COG2:

    Component of oligomeric golgi complex 2
    Hs.211800  [show with all ESTs]
    Unigene Representative Sequence: NM_007357
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494371 ENST00000366669(uc001htw.3 uc001htx.3 uc010pwc.2)
    ENST00000468893 ENST00000473671 ENST00000366668 ENST00000534989 ENST00000482012
    ENST00000490900 ENST00000478710 ENST00000535166 ENST00000546013
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COG2 (see all 15):
    hsa-miR-3163 hsa-miR-3607-3p hsa-miR-607 hsa-miR-548am hsa-miR-3688-3p hsa-miR-625* hsa-miR-411 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidCOG2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COG2
    Predesigned siRNA for gene silencing in human, mouse, rat COG2
    Clone
    Products:
         
    OriGene clones in human, mouse for COG2 (see all 12)
    OriGene ORF clones in mouse, rat for COG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): COG2 (NM_001145036)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COG2
    OriGene qSTAR qPCR primer pairs in human, mouse for COG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COG2
      QuantiTect SYBR Green Assays in human, mouse, rat COG2
      QuantiFast Probe-based Assays in human, mouse, rat COG2

    Additional mRNA sequence: 

    AK295251.1 AK302288.1 AK312678.1 BC014960.1 BC051906.1 S77362.1 Z34975.1 

    10 DOTS entries:

    DT.316057  DT.316058  DT.121399389  DT.100778663  DT.408626  DT.97842631  DT.75109492  DT.40234203 
    DT.40295055  DT.95367489 

    Selected AceView cDNA sequences (see all 208):

    CB128739 AA236106 BM926913 AU143218 BM752182 BF513609 BF512611 BU729559 
    BC014960 CR625249 BX483504 AU131150 BQ067412 BX116392 AA262639 AI422718 
    AU133010 BX420206 BU616835 BF002124 BC051906 AA832272 AI985310 AU124934 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COG2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^
    SP1:                                -                                               -     -           -                                   -                 -   
    SP2:                                -                                               -     -           -                                   -                 -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for COG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    COG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTCTTCTCT
    COG2 Expression
    About this image

    COG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211800
        Custom PCR Arrays for COG2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COG2
    OriGene qSTAR qPCR primer pairs in human, mouse for COG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COG2
    QuantiTect SYBR Green Assays in human, mouse, rat COG2
    QuantiFast Probe-based Assays in human, mouse, rat COG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COG2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cog21 , 5 component of oligomeric golgi complex 21, 5 81.19(n)1
    86.3(a)1
      8 (72.78 cM)5
    763321  NM_029746.31  NP_084022.21 
     1245207675 
    chicken
    (Gallus gallus)
    Aves COG21 component of oligomeric golgi complex 2 77.66(n)
    80.05(a)
      421542  XM_419583.4  XP_419583.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    85(a)
    74(a)
    many → 1
    many → 1
    GL344499.1(4975-20645)
    1(222808584-222824795)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.111162 Transcribed sequence with moderate similarity to protein more 78.05(n)    AL856741.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj87b022 Danio rerio mRNA similar to component of oligomeric more 73.67(n)    BC049314.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ldlCp1 , 3 exocytosis3
    ldlCp-related protein1
    32(a)3
    45.46(n)1
    36.39(a)1
      88F13
    418701  NM_079642.31  NP_524366.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cogc-21 cogc-2 39.37(n)
    27.57(a)
      177473  NM_068691.5  NP_501092.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G248401 AT4G24840 43.55(n)
    31.94(a)
      828587  NM_118617.4  NP_567710.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08496001 Os03g0849600 42.73(n)
    30.69(a)
      4334786  NM_001058433.1  NP_001051898.1 


    ENSEMBL Gene Tree for COG2 (if available)
    TreeFam Gene Tree for COG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for COG2 (see all 1207)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101583101,2
    C,F--230776264(+) AAAATG/ATCAGG 2 -- us2k15Minor allele frequency- A:0.16NA WA EA 362
    rs1874961401,2
    --230776272(+) AGGGTC/TTTTTT 2 -- us2k10--------
    rs731162441,2
    C,F--230776292(+) TGATGC/TGTAAA 2 -- us2k12Minor allele frequency- T:0.09WA NA 238
    rs1924918531,2
    C--230776293(+) GATGCA/GTAAAC 2 -- us2k10--------
    rs790224131,2
    C--230776381(+) AGTGGT/CTCATG 2 -- us2k13Minor allele frequency- C:0.10WA NA 240
    rs1858093251,2
    --230776425(+) GGTGGA/GTCATC 2 -- us2k10--------
    rs1115584521,2
    C,F--230776434(+) TCTGAG/AGTCAG 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs43991681,2
    C,A--230776438(+) AGGTCG/AGGGGT 2 -- us2k1 tfbs35Minor allele frequency- A:0.10NA WA 10
    rs1927508821,2
    --230776545(+) GGGAGG/TCTGAG 2 -- us2k10--------
    rs1846418671,2
    --230776605(+) TCATGA/CCATTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for COG2 (230778202 - 230829731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for COG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832836CNV Loss17160897
    nsv524949CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COG2
    DNA2.0 Custom Variant and Variant Library Synthesis for COG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606974    OMIM disorders: --

    9 diseases for COG2:    
    About MalaCards
    carotid artery thrombosis    hyperlipoproteinemia type iii    familial hypercholesterolemia    familial hyperlipidemia
    hypercholesterolemia    vascular disease    artery disease    type 2 diabetes mellitus
    coronary artery disease

    7 diseases from the University of Copenhagen DISEASES database for COG2:
    Coronary heart disease     Atherosclerosis     Diabetes mellitus     Familial hyperlipidemia
    Hypertension     Myocardial infarction     Cerebrovascular accident

    Find genes that share disorders with COG2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for COG2 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypercholesterolemia 79.5 57 19678716 (2), 7573090 (2), 17036098 (2), 16404837 (2) (see all 39)
    hypercholesterolemia familial 76.7 15 1959928 (2), 1415054 (2), 1770303 (1), 20506408 (1) (see all 13)
    coronary heart disease 76.7 47 8105786 (1), 11191012 (1), 12023827 (1), 16522931 (1) (see all 37)
    dyslipidemia 75.8 31 11376309 (2), 17847038 (2), 11849617 (1), 8696067 (1) (see all 18)
    hyperlipidemia 63 7 12839659 (2), 10998478 (2), 18257145 (1), 19328972 (1) (see all 5)
    cardiovascular diseases 62.4 11 16185099 (1), 15177127 (1), 17636341 (1), 17996658 (1) (see all 11)
    coronary artery disease 60.4 18 7604802 (2), 11374858 (1), 8017467 (1), 16608374 (1) (see all 15)
    atherosclerosis 59 26 14745143 (2), 19702110 (2), 10365572 (1), 16415542 (1) (see all 22)
    combined hyperlipidemia 58.5 1 14728015 (1)
    niddm 55.2 12 7573090 (2), 19465013 (1), 15040041 (1), 19344229 (1) (see all 8)

    Genetic Association Database (GAD): COG2
    Human Genome Epidemiology (HuGE) Navigator: COG2 (4 documents)

    Export disorders for COG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for COG2 gene, integrated from 10 sources (see all 511):
    (articles sorted by number of sources associating them with COG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function. (PubMed id 7962052)1, 2, 3 Podos S.D.... Krieger M. (J. Cell Biol. 1994)
    2. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. (PubMed id 19105203)1, 4 Edwards T.L....Ritchie M.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22796 HGNC: 6546 AceView: COG2 Ensembl:ENSG00000135775 euGenes: HUgn22796
    ECgene: COG2 H-InvDB: COG2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for COG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for COG2 gene:
    Search GeneIP for patents involving COG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for COG2  
     OriGene qPCR primer pairs and template standards for COG2   OriGene Protein Over-expression Lysate for COG2  
     OriGene MassSpec for COG2   OriGene clones in human, mouse for COG2  
     OriGene qSTAR qPCR primer pairs in human, mouse for COG2   OriGene Purified Protein for COG2  
     OriGene ORF clones in mouse, rat for COG2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for COG2   OriGene Custom Protein Services for COG2  

     
     
     Block miRNA regulation of human, mouse, rat COG2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing COG2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COG2 Predesigned siRNA for gene silencing in human, mouse, rat COG2
     QuantiFast Probe-based Assays in human, mouse, rat COG2 QuantiTect SYBR Green Assays in human, mouse, rat COG2
     Custom PCR Arrays for COG2 Search Chromatin IP Primers for COG2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COG2  GeneGlobe Interaction Network for COG2
     Regulatory tfbs in COG2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for COG2 GenScript cDNA clones with any tag delivered in your preferred vector for COG2
     GenScript Custom Assay Services for COG2 GenScript Custom overexpressing Cell Line Services for COG2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for COG2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for COG2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     COG2 antibodies
     COG2 proteins
     COG2 lysates
     Antibodies for COG2
     See all of Abcam's Antibodies, Kits and Proteins for COG2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for COG2
     Antibodies for COG2
     ELISAs for COG2
     CLIAs for COG2



     Browse ESI BIO Cell Lines and PureStem Progenitors for COG2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG2
     SwitchGear 3'UTR luciferase reporter plasmids for COG2
     SwitchGear Promoter luciferase reporter plasmids for COG2
     ThermoFisher Antibody for COG2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG2
     Browse compounds at ApexBio
     Search Addgene for plasmids for COG2
      Search eBioscience for proteins for COG2
      Search eBioscience for elisas for COG2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for COG2
     antibodies-online antibodies for COG2 (23 products)
     antibodies-online kits for COG2 (4 products)
     antibodies-online peptides for COG2
     antibodies-online proteins for COG2 (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      COG2 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4