Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COG2 Gene

Aliases for COG2 Gene

  • Component Of Oligomeric Golgi Complex 2 2 3 4
  • LDLC 3 4 6
  • Low Density Lipoprotein Receptor Defect C-Complementing Protein 3 4
  • Low Density Lipoprotein Receptor Defect C Complementing 2 3
  • COG Complex Subunit 2 3 4
  • Brefeldin A-Sensitive, Peripheral Golgi Protein 3
  • Conserved Oligomeric Golgi Complex Protein 2 3
  • Conserved Oligomeric Golgi Complex Subunit 2 3

External Ids for COG2 Gene

Previous HGNC Symbols for COG2 Gene

  • LDLC

Previous GeneCards Identifiers for COG2 Gene

  • GC01P229255
  • GC01P226506
  • GC01P227251
  • GC01P227813
  • GC01P227084
  • GC01P228844
  • GC01P230778
  • GC01P201264

Summaries for COG2 Gene

Entrez Gene Summary for COG2 Gene

  • This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for COG2 Gene

COG2 (Component Of Oligomeric Golgi Complex 2) is a Protein Coding gene. Diseases associated with COG2 include carotid artery thrombosis and hyperlipoproteinemia type iii. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot for COG2 Gene

  • Required for normal Golgi morphology and function

Gene Wiki entry for COG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COG2 Gene

Genomics for COG2 Gene

Genomic Location for COG2 Gene

Start:
230,642,456 bp from pter
End:
230,693,985 bp from pter
Size:
51,530 bases
Orientation:
Plus strand

Genomic View for COG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COG2 Gene

Proteins for COG2 Gene

  • Protein details for COG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14746-COG2_HUMAN
    Recommended name:
    Conserved oligomeric Golgi complex subunit 2
    Protein Accession:
    Q14746
    Secondary Accessions:
    • Q86U99

    Protein attributes for COG2 Gene

    Size:
    738 amino acids
    Molecular mass:
    83208 Da
    Quaternary structure:
    • Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization

    Alternative splice isoforms for COG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COG2 Gene

Proteomics data for COG2 Gene at MOPED

Post-translational modifications for COG2 Gene

  • Ubiquitination at Lys54, Lys188, Lys584, and Lys717
  • Modification sites at PhosphoSitePlus

Other Protein References for COG2 Gene

No data available for DME Specific Peptides for COG2 Gene

Domains for COG2 Gene

Gene Families for COG2 Gene

HGNC:
  • COG :Components of oligomeric golgi complex

Protein Domains for COG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14746

UniProtKB/Swiss-Prot:

COG2_HUMAN :
  • Q14746
Family:
  • Belongs to the COG2 family.
genes like me logo Genes that share domains with COG2: view

Function for COG2 Gene

Molecular function for COG2 Gene

UniProtKB/Swiss-Prot Function: Required for normal Golgi morphology and function

Gene Ontology (GO) - Molecular Function for COG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15047703
GO:0008565 protein transporter activity IMP 7962052
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with COG2: view

Phenotypes for COG2 Gene

MGI mutant phenotypes for COG2:
inferred from 1 alleles
GenomeRNAi human phenotypes for COG2:
genes like me logo Genes that share phenotypes with COG2: view

miRNA for COG2 Gene

miRTarBase miRNAs that target COG2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COG2 Gene

Localization for COG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COG2 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COG2 Gene COMPARTMENTS Subcellular localization image for COG2 gene
Compartment Confidence
golgi apparatus 5
extracellular 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for COG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005795 Golgi stack IDA 7962052
GO:0005829 cytosol IEA --
GO:0016020 membrane --
GO:0017119 Golgi transport complex IMP 7962052
genes like me logo Genes that share ontologies with COG2: view

Pathways for COG2 Gene

SuperPathways for COG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation TAS 7962052
GO:0006886 intracellular protein transport TAS 7962052
GO:0006891 intra-Golgi vesicle-mediated transport IMP 7962052
GO:0007030 Golgi organization IMP 7962052
GO:0009312 oligosaccharide biosynthetic process TAS 7962052
genes like me logo Genes that share ontologies with COG2: view

No data available for Pathways by source for COG2 Gene

Compounds for COG2 Gene

(65) Novoseek inferred chemical compound relationships for COG2 Gene

Compound -log(P) Hits PubMed IDs
cholesterol 89.7 248
atorvastatin 81.1 107
ezetimibe 81 55
rosuvastatin 80.9 70
lipid 80.1 129
genes like me logo Genes that share compounds with COG2: view

Transcripts for COG2 Gene

Unigene Clusters for COG2 Gene

Component of oligomeric golgi complex 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COG2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6:

ExUns: 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for COG2 Gene

GeneLoc Exon Structure for
COG2
ECgene alternative splicing isoforms for
COG2

Expression for COG2 Gene

mRNA expression in normal human tissues for COG2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COG2 Gene

SOURCE GeneReport for Unigene cluster for COG2 Gene Hs.211800

genes like me logo Genes that share expressions with COG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COG2 Gene

Orthologs for COG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COG2 35
  • 99.5 (n)
  • 99.59 (a)
COG2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COG2 35
  • 87.13 (n)
  • 89.7 (a)
COG2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-1841 36
  • 91 (a)
OneToOne
COG2 35
  • 89.59 (n)
  • 92.3 (a)
mouse
(Mus musculus)
Mammalia Cog2 35
  • 81.19 (n)
  • 86.3 (a)
Cog2 16
Cog2 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COG2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COG2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cog2 35
  • 80.96 (n)
  • 85.75 (a)
chicken
(Gallus gallus)
Aves COG2 35
  • 77.66 (n)
  • 80.05 (a)
COG2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cog2 35
  • 69.21 (n)
  • 70.71 (a)
Str.11116 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4936 35
zebrafish
(Danio rerio)
Actinopterygii cog2 35
  • 65.79 (n)
  • 70.21 (a)
cog2 36
  • 69 (a)
OneToOne
wufj87b02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003824 35
  • 45.35 (n)
  • 35.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta ldlCp 35
  • 45.46 (n)
  • 36.39 (a)
ldlCp 36
  • 34 (a)
OneToOne
ldlCp 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea cogc-2 35
  • 39.37 (n)
  • 27.57 (a)
cogc-2 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24840 35
  • 43.55 (n)
  • 31.94 (a)
rice
(Oryza sativa)
Liliopsida Os03g0849600 35
  • 42.73 (n)
  • 30.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for COG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COG2 Gene

ENSEMBL:
Gene Tree for COG2 (if available)
TreeFam:
Gene Tree for COG2 (if available)

Paralogs for COG2 Gene

No data available for Paralogs for COG2 Gene

Variants for COG2 Gene

Sequence variations from dbSNP and Humsavar for COG2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs943579 -- 230,679,630(+) TTTCA(C/T)GATGA intron-variant
rs1007456 -- 230,685,827(-) AGGTC(C/T)CAGCA intron-variant
rs1051038 -- 230,693,393(+) CCTTA(A/G)GCATC reference, synonymous-codon
rs1359866 -- 230,659,431(-) ATTAT(A/G)GCAAT intron-variant
rs1410142 -- 230,692,692(-) CTCTG(C/T)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COG2 Gene

Variant ID Type Subtype PubMed ID
nsv524949 CNV Loss 19592680
nsv832836 CNV Loss 17160897

Relevant External Links for COG2 Gene

HapMap Linkage Disequilibrium report
COG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COG2 Gene

Disorders for COG2 Gene

(48) Novoseek inferred disease relationships for COG2 Gene

Disease -log(P) Hits PubMed IDs
hypercholesterolemia 79.5 49
hypercholesterolemia familial 76.7 15
coronary heart disease 76.7 37
dyslipidemia 75.8 20
hyperlipidemia 63 7

Relevant External Links for COG2

Genetic Association Database (GAD)
COG2
Human Genome Epidemiology (HuGE) Navigator
COG2
genes like me logo Genes that share disorders with COG2: view

No data available for UniProtKB/Swiss-Prot for COG2 Gene

Publications for COG2 Gene

  1. LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function. (PMID: 7962052) Podos S.D. … Krieger M. (J. Cell Biol. 1994) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 48
  4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 48
  5. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. (PMID: 19105203) Edwards T.L. … Ritchie M.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48

Products for COG2 Gene

Sources for COG2 Gene

Back to Top

Content