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COG1 Gene

protein-coding   GIFtS: 53
GCID: GC17P071189

Component Of Oligomeric Golgi Complex 1

(Previous name: low density lipoprotein receptor defect B complementing)
(Previous symbol: LDLB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Component Of Oligomeric Golgi Complex 11 2 3     CDG2G2 5
LDLB1 2 3 5     KIAA13813 5
Low Density Lipoprotein Receptor Defect B Complementing1 2     Conserved Oligomeric Golgi Complex Protein 12
COG Complex Subunit 12 3     Conserved Oligomeric Golgi Complex Subunit 12

External Ids:    HGNC: 65451   Entrez Gene: 93822   Ensembl: ENSG000001666857   OMIM: 6069735   UniProtKB: Q8WTW33   

Export aliases for COG1 gene to outside databases

Previous GC identifers: GC17P071074 GC17P074229 GC17P071653 GC17P071786 GC17P068700 GC17P066598


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COG1 Gene:
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG)
required for normal Golgi morphology and function. It is thought that this protein is required for steps in the
normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of
the Golgi-localized complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for COG1 Gene:
COG1 (component of oligomeric golgi complex 1) is a protein-coding gene. Diseases associated with COG1 include cerebrocostomandibular-like syndrome, and congenital disorder of glycosylation type 2g.

UniProtKB/Swiss-Prot: COG1_HUMAN, Q8WTW3
Function: Required for normal Golgi function (By similarity)

Gene Wiki entry for COG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the COG1 gene promoter:
         ISGF-3   RP58   AP-1   MIF-1   Tal-1beta   POU3F2   c-Ets-1   Evi-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOG1 promoter sequence
   Search Chromatin IP Primers for COG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

COG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COG1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P071189:  view genomic region     (about GC identifiers)

Start:
71,189,129 bp from pter      End:
71,204,646 bp from pter
Size:
15,518 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COG1_HUMAN, Q8WTW3 (See protein sequence)
Recommended Name: Conserved oligomeric Golgi complex subunit 1  
Size: 980 amino acids; 108978 Da
Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is
required for normal Golgi morphology and localization
Sequence caution: Sequence=BAA92619.1; Type=Frameshift; Positions=937;
Secondary accessions: Q9NPV9 Q9P2G6

Explore the universe of human proteins at neXtProt for COG1: NX_Q8WTW3

Explore proteomics data for COG1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061184.1  
    ENSEMBL proteins: 
     ENSP00000299886   ENSP00000400111   ENSP00000462101   ENSP00000463696   ENSP00000463298  
     ENSP00000462709  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COG: Components of oligomeric golgi complex

    ProtoNet protein and cluster: Q8WTW3

    UniProtKB/Swiss-Prot: COG1_HUMAN, Q8WTW3
    Similarity: Belongs to the COG1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COG1_HUMAN, Q8WTW3
    Function: Required for normal Golgi function (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15047703
         
    COG1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for COG1:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COG1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COG1

    miRNA
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    miRTarBase miRNAs that target COG1:
    hsa-mir-149-5p (MIRT045480), hsa-mir-484 (MIRT042242)

    Block miRNA regulation of human, mouse, rat COG1 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat COG1

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    GenScript: all cDNA clones in your preferred vector: COG1 (NM_018714)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COG1_HUMAN, Q8WTW3: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol2
    extracellular2
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus IDA11980916
    GO:0017119Golgi transport complex NAS11980916

    COG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COG1
    Interactions:

        GeneGlobe Interaction Network for COG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for COG1 (Q8WTW31, 3 ENSP000002998864) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COG4Q9H9E31, 3, ENSP000003157754EBI-368371,EBI-368382 I2D: score=3 STRING: ENSP00000315775
    COG3Q96JB23, ENSP000002586544I2D: score=1 STRING: ENSP00000258654
    COG8Q96MW53, ENSP000003054594I2D: score=5 STRING: ENSP00000305459
    OGFOD1Q8N5433I2D: score=4 
    PIGSQ96S523I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006891intra-Golgi vesicle-mediated transport NAS11980916
    GO:0007030Golgi organization NAS11980916
    GO:0015031protein transport IEA--

    COG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COG1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COG1 gene: 
    NM_018714.2  

    Unigene Cluster for COG1:

    Component of oligomeric golgi complex 1
    Hs.103555  [show with all ESTs]
    Unigene Representative Sequence: AB037802
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299886(uc002jjg.3 uc002jjh.3) ENST00000438720(uc002jjf.1)
    ENST00000582587 ENST00000577844 ENST00000580271 ENST00000582512 ENST00000577238
    ENST00000582672 ENST00000582973
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat COG1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COG1
    Primer
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    OriGene qPCR primer pairs and template standards for COG1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COG1
      QuantiTect SYBR Green Assays in human, mouse, rat COG1
      QuantiFast Probe-based Assays in human, mouse, rat COG1

    Additional mRNA sequence: 

    AB037802.1 AB593171.1 AK025633.1 AK098224.1 AL359611.1 BC021985.2 BC047465.1 

    20 DOTS entries:

    DT.95156930  DT.100029671  DT.100824747  DT.40120363  DT.99989533  DT.91766570  DT.100824751  DT.120979072 
    DT.40227861  DT.120979048  DT.100736951  DT.209499  DT.95246244  DT.120979174  DT.91766573  DT.95363736 
    DT.100824753  DT.95156940  DT.120979095  DT.40120297 

    Selected AceView cDNA sequences (see all 209):

    CA777807 AK025633 AI831481 BQ668601 BC021985 NM_018714 N77918 BF589019 
    AW136676 CR603633 AI806099 AB037802 AI123321 BQ723452 BQ022924 AI521632 
    AW673164 CB242447 AI285992 AW249944 AW027835 AI820008 AI494531 BM707725 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COG1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:              -                                                                                                               
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for COG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAACACATC
    COG1 Expression
    About this image


    COG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    COG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.103555
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COG1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cog11 , 5 component of oligomeric golgi complex 11, 5 84.44(n)1
    85.77(a)1
      11 (79.10 cM)5
    168341  NM_013581.31  NP_038609.31 
     1136491695 
    chicken
    (Gallus gallus)
    Aves COG11 component of oligomeric golgi complex 1 71.93(n)
    71.26(a)
      417449  NM_001030707.2  NP_001025878.2 
    lizard
    (Anolis carolinensis)
    Reptilia COG16
    component of oligomeric golgi complex 1
    66(a)
    1 ↔ 1
    2(96787027-96807947)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.129352 Xenopus laevis transcribed sequence with weak similarity more 72.84(n)    CD328649.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wuft63e052 wuft63e05 78.25(n)   386849  BM531305.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48481 CG4848 42.34(n)
    28.59(a)
      41479  NM_141905.3  NP_650162.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G163001 AT5G16300 41.68(n)
    29.12(a)
      831491  NM_121635.3  NP_197134.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07770001 Os01g0777000 42.98(n)
    29.52(a)
      4327897  NM_001050954.1  NP_001044419.1 


    ENSEMBL Gene Tree for COG1 (if available)
    TreeFam Gene Tree for COG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COG1 gene

    COG1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for COG1
    PGOHUM00000241793


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COG1 (see all 563)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112948041,2
    C--71187919(+) GTTTCT/-TTTTT 1 -- us2k1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs612282711,2
    C--71188973(+) CCCGCC/G/TCCCGC 1 -- us2k12NA 4
    rs80760091,2
    C--71188985(+) cccgcC/Gcccgc 1 -- us2k10--------
    rs96751301,2
    C--71188992(+) ccgccC/Tcctcg 1 -- us2k10--------
    rs75030071,2
    C--71189069(+) ctcgcC/Gcccgc 1 -- us2k10--------
    rs75031661,2
    C--71189076(+) ccgccC/Tcctcg 1 -- us2k1 ese30--------
    rs3771241051,2
    C--71189076(+) CGCCC-/CCGCCT
            
    CCTCG
    2 -- us2k1 cds10--------
    rs30712851,2
    C--71189155(-) CCCCC-/CC/CCC
            
    TCCGC
    2 -- us2k1 cds10--------
    rs1129863781,2
    C,F--71190813(+) GGCCCG/AGCTGG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1124686371,2
    C,F--71191707(+) ATGATC/AGCACC 1 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for COG1 (71189129 - 71204646 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for COG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2104946CNV Deletion18987734
    esv2716191CNV Deletion23290073
    nsv833534CNV Loss17160897

    Human Gene Mutation Database (HGMD): COG1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COG1
    DNA2.0 Custom Variant and Variant Library Synthesis for COG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606973   
    OMIM disorders: 611209  
    UniProtKB/Swiss-Prot: COG1_HUMAN, Q8WTW3
  • Congenital disorder of glycosylation 2G (CDG2G) [MIM:611209]: A multisystem disorder caused by a defect
    in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of
    glycosylation result in a wide variety of clinical features, such as defects in the nervous system development,
    psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad
    spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation,
    and maintenance of cell functions. Clinical features of CDG2G include failure to thrive, generalized hypotonia,
    growth retardation and mild psychomotor retardation. CDG2G is biochemically characterized by a defect in
    O-glycosylation as well as N-glycosylation. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 17 diseases for COG1:    
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    cerebrocostomandibular-like syndrome    congenital disorder of glycosylation type 2g    congenital disorder of glycosylation type ii    spondylocostal dysostosis
    dysostosis    congenital disorder of glycosylation, type it    xanthomatosis    congenital disorder of glycosylation
    hypotonia    tonsillitis    malaria    multiple myeloma
    myeloma    cerebritis    thyroiditis    endotheliitis
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for COG1:
    Congenital disorder of glycosylation

    COG1 for disorders           About GeneDecksing

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    Export disorders for COG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COG1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with COG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PubMed id 11980916)1, 2 Ungar D.... Waters M.G. (J. Cell Biol. 2002)
    3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    4. Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex. (PubMed id 9927668)1, 3 Chatterton J.E....Krieger M. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    5. Conserved oligomeric Golgi complex subunit 1 deficiency reveals a previously uncharacterized congenital disorder of glycosylation type II. (PubMed id 16537452)2, 9 Foulquier F.... Matthijs G. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    6. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9382 HGNC: 6545 AceView: COG1 Ensembl:ENSG00000166685 euGenes: HUgn9382
    ECgene: COG1 H-InvDB: COG1

    (According to HUGE)
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    HUGE: KIAA1381

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COG1 gene:
    Search GeneIP for patents involving COG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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