COBLL1 Gene
protein-coding GIFtS : 52
GCID: GC02 M165510
cordon-bleu WH2 repeat protein-like 1 (Previous name: COBL-like 1 )
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Aliasesfor COBLL1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cordon-Bleu WH2 Repeat Protein-Like 1 1 2 COBL-Like 11 2 KIAA09771 3 COBLR12 Cordon-Bleu Protein-Like 12
Export aliases for COBLL1 gene to outside databases Previous GC identifers: GC02M165743 GC02M165366 GC02M165249 GC02M157423
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Summariesfor COBLL1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for COBLL1
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Genomic Viewsfor COBLL1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_005403.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the COBLL1 gene promoter: SRF NF-1 FOXF2 Pbx1a ATF-2 SRF (504 AA) MyoD Nkx2-5 AREB6 CP2 Other transcription factors Search SABiosciences Chromatin IP Primers for COBLL1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat COBLL1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q24.3 COBLL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M165510: view genomic region
(about GC identifiers )
Start:
165,510,134 bp from pter
End:
165,700,189 bp from pter
Size:
190,056 bases
Orientation:
minus strand
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Proteinsfor COBLL1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: COBL1_HUMAN, Q53SF7 (See
protein sequence )Recommended Name: Cordon-bleu protein-like 1 Size : 1204 amino acids; 131787 Da
Sequence caution : Sequence=BAA76821.2; Type=Erroneous initiation; Sequence=CAB43215.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for COBLL1 :2DAJ (3D)
 
Secondary accessions : A6NMZ3 Q6IQ33 Q7Z3I6 Q9BRH4 Q9UG88 Q9Y2I3Alternative splicing : 5 isoforms : Q53SF7-1 Q53SF7-2 Q53SF7-3 Q53SF7-4 Q53SF7-5 Explore the universe of human proteins at neXtProt for COBLL1: NX_Q53SF7 COBLL1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_055715.3 ENSEMBL proteins: ENSP00000364607 ENSP00000341360 ENSP00000387326 ENSP00000416311 ENSP00000400146 ENSP00000397520 ENSP00000406062 ENSP00000397835 ENSP00000409237 ENSP00000387967 ENSP00000388110 ENSP00000194871 ENSP00000376478 Human Recombinant Protein Products for COBLL1: COBLL1 Antibody Products: Assay Products for COBLL1:
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Protein
Domains / Familiesfor COBLL1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
COBLL1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q53SF7 ProtoNet protein and cluster: Q53SF7
1 Blocks protein family : IPB003124 Actin-binding WH2 UniProtKB/Swiss-Prot: COBL1_HUMAN, Q53SF7 Similarity : Contains 1 WH2 domain
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Functionfor COBLL1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003779 actin binding
IEA --
COBLL1 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for COBLL1 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for COBLL1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for COBLL1 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: COBLL1 (NM_014900 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COBLL1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat COBLL1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COBLL1
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Pathways & Interactionsfor COBLL1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COBLL1 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for COBLL1 (Q53SF7 3 ENSP00000194871 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor COBLL1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for COBLL1 Search CenterWatch for drugs/clinical trials and news about COBLL1 / COBL1
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Transcriptsfor COBLL1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for COBLL1 gene: NM_014900.3 Unigene Cluster for COBLL1:
Cordon-bleu WH2 repeat protein-like 1 Hs.470457 [show with all ESTs ] Unigene Representative Sequence: BX649112 18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25 ): ENST00000495084 ENST00000375458 (uc002ucq.3 ) ENST00000342193 (uc002ucp.3 )ENST00000409184 (uc010zcx.2 ) ENST00000493868 (uc002uco.3 ) ENST00000489955 (uc002ucn.3 )ENST00000493713 ENST00000456171 ENST00000491126 ENST00000460238 ENST00000434366 ENST00000474975 ENST00000452626 ENST00000456693 ENST00000448708 ENST00000439313 ENST00000444537 ENST00000414843 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for COBLL1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for COBLL1 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: COBLL1 (NM_014900 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COBLL1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat COBLL1
Additional cDNA sequence: AB023194.1 AK001813.1 AK002054.1 AK002057.1 AK075181.1 AK225849.1 AK294937.1 AL049939.1 BC006264.2 BC071588.1 BX649112.1
20 DOTS entries : DT.99933044 DT.100838658
DT.452816 DT.91658233 DT.100722412 DT.308876 DT.92435937 DT.86849616 DT.92043622 DT.100693568 DT.403473 DT.95099218 DT.120935353 DT.120935361 DT.40204880 DT.91844715 DT.95099171 DT.95099222 DT.120935371 DT.92417763 24/298 AceView cDNA sequences (see all 298 ):
AI668900 AU156939 BM748953 BX438772 AA766062 AI262946 AA938743 AI373437 AA677181 AI244957 BU431602 AI382724 AA682470 CB162565 BM843342 BQ022875 BX089326 BP334569 CA392907 H03956 BC006264 AI669563 AA827847 CR590777 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for COBLL1 (see all 9 ) About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^ 17 ^ SP1 :       -     -       -   -       -         -             -       -   SP2 :   -     -     -         -       -                             SP3 :       -     -       -   -       -         -   -           -       -   SP4 :           -       -   -                                   SP5 :                         -                            
ExUns: 18 ^ 19a · 19b SP1 :       SP2 :       SP3 :       SP4 :       SP5 :      
ECgene alternative splicing isoforms for COBLL1
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Expression for COBLL1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section COBLL1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAACTCTTGTAbout this image COBLL1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See COBLL1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for COBLL1 SOURCE GeneReport for Unigene cluster: Hs.470457 SABiosciences Custom PCR Arrays for COBLL1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for COBLL1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat COBLL1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat COBLL1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat COBLL1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COBLL1
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Orthologsfor COBLL1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for COBLL1 gene from 4/11 species (see all 11 ) About this table
ENSEMBL Gene Tree for COBLL1 (if available)TreeFam Gene Tree for COBLL1 (if available)
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Paralogsfor COBLL1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for COBLL1 gene COBL 2 1 SIMAP similar gene for COBLL1 using alignment to 9 protein entries: COBL1_HUMAN (see all proteins ):COBL
COBLL1 for paralogs About GeneDecksing
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Genomic Variantsfor COBLL1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for COBLL1 (165510134 - 165700189 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for COBLL1 2 CNVs : 8393 98044 1 Indel : 45895 Human Gene Mutation Database (HGMD) : COBLL1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing COBLL1
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Disorders
/ Diseasesfor COBLL1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
COBLL1 for disorders About GeneDecksing
OMIM gene information: 610318
OMIM disorders : --3 diseases for COBLL1 : About MalaCards malignant pleural mesothelioma benign mesothelioma conduct disorder Human Genome Epidemiology (HuGE) Navigator: COBLL1 (2 documents) Export disorders for COBLL1 gene to outside databases
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Publicationsfor COBLL1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for COBLL1 gene, integrated from 9 sources (see all 21 ): (articles sorted by number of sources associating them with COBLL1) Utopia : connect your pdf to the dynamic world of online information
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 1 , 2 Beausoleil S.A.... Gygi S.P. (2006) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 1 , 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032) 1 , 2 Nagase T.... Ohara O. (1999) A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228) 1 Manning A.K....Langenberg C. (2012) Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. (PubMed id 22294699) 1 Li J....Wong J. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Genes associated with prognosis after surgery for mal ignant pleural mesothelioma promote tumor cell survival in vitro. (PubMed id 21569526) 1 Gordon G.J....Sugarbaker D.J. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565) 1 Teslovich T.M....Kathiresan S. (2010)
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External Searches for COBLL1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing COBLL1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing COBLL1 gene
(According to HUGE )
About This Section
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Specialized Databases showing COBLL1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for COBLL1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for COBLL1 gene: Search GeneIP for patents involving COBLL1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor COBLL1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for COBLL1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for COBLL1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for COBLL1 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for COBLL1 OriGene 3'-UTR Clone for COBLL1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for COBLL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for COBLL1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for COBLL1 OriGene Custom Protein Services for COBLL1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COBLL1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing COBLL1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat COBLL1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat COBLL1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat COBLL1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat COBLL1
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COBLL1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COBLL1
Search ThermoFisher Antibodies for COBLL1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat COBLL1
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Aliases for COBLL1
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Expression for COBLL1
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