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Aliases for COBLL1 Gene

Aliases for COBLL1 Gene

  • Cordon-Bleu WH2 Repeat Protein-Like 1 2 3
  • COBL-Like 1 2 3
  • KIAA0977 4 6
  • COBLR1 3 6
  • Cordon-Bleu Protein-Like 1 3

External Ids for COBLL1 Gene

Previous GeneCards Identifiers for COBLL1 Gene

  • GC02M165743
  • GC02M165366
  • GC02M165249
  • GC02M165510
  • GC02M157423

Summaries for COBLL1 Gene

GeneCards Summary for COBLL1 Gene

COBLL1 (Cordon-Bleu WH2 Repeat Protein-Like 1) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is COBL.

Gene Wiki entry for COBLL1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COBLL1 Gene

Genomics for COBLL1 Gene

Regulatory Elements for COBLL1 Gene

Genomic Location for COBLL1 Gene

Start:
164,653,624 bp from pter
End:
164,843,679 bp from pter
Size:
190,056 bases
Orientation:
Minus strand

Genomic View for COBLL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COBLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COBLL1 Gene

Proteins for COBLL1 Gene

  • Protein details for COBLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53SF7-COBL1_HUMAN
    Recommended name:
    Cordon-bleu protein-like 1
    Protein Accession:
    Q53SF7
    Secondary Accessions:
    • A6NMZ3
    • Q6IQ33
    • Q7Z3I6
    • Q9BRH4
    • Q9UG88
    • Q9Y2I3

    Protein attributes for COBLL1 Gene

    Size:
    1204 amino acids
    Molecular mass:
    131787 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76821.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43215.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COBLL1 Gene

    Alternative splice isoforms for COBLL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COBLL1 Gene

Proteomics data for COBLL1 Gene at MOPED

Post-translational modifications for COBLL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COBLL1 Gene

Domains for COBLL1 Gene

Protein Domains for COBLL1 Gene

Suggested Antigen Peptide Sequences for COBLL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53SF7

UniProtKB/Swiss-Prot:

COBL1_HUMAN :
  • Q53SF7
Domain:
  • Contains 1 WH2 domain.
genes like me logo Genes that share domains with COBLL1: view

No data available for Gene Families for COBLL1 Gene

Function for COBLL1 Gene

Gene Ontology (GO) - Molecular Function for COBLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with COBLL1: view

Phenotypes for COBLL1 Gene

GenomeRNAi human phenotypes for COBLL1:
genes like me logo Genes that share phenotypes with COBLL1: view

miRNA for COBLL1 Gene

miRTarBase miRNAs that target COBLL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COBLL1 Gene

Localization for COBLL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COBLL1 Gene COMPARTMENTS Subcellular localization image for COBLL1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for COBLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with COBLL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for COBLL1 Gene

Pathways for COBLL1 Gene

SuperPathways for COBLL1 Gene

No Data Available

Interacting Proteins for COBLL1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341360%0d%0a9606.ENSP00000346890%0d%0a9606.ENSP00000244458%0d%0a
Selected Interacting proteins: ENSP00000341360 Q53SF7-COBL1_HUMAN for COBLL1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for COBLL1 Gene

None

No data available for Pathways by source for COBLL1 Gene

Transcripts for COBLL1 Gene

Unigene Clusters for COBLL1 Gene

Cordon-bleu WH2 repeat protein-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COBLL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^ 17 ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: -
SP6: - -
SP7: -
SP8: - -
SP9:

ExUns: 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for COBLL1 Gene

GeneLoc Exon Structure for
COBLL1
ECgene alternative splicing isoforms for
COBLL1

Expression for COBLL1 Gene

mRNA expression in normal human tissues for COBLL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COBLL1 Gene

This gene is overexpressed in Adrenal Gland (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COBLL1 Gene

SOURCE GeneReport for Unigene cluster for COBLL1 Gene Hs.470457

genes like me logo Genes that share expressions with COBLL1: view

No data available for mRNA Expression by UniProt/SwissProt for COBLL1 Gene

Orthologs for COBLL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COBLL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COBLL1 35
  • 99.49 (n)
  • 99.11 (a)
COBLL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COBLL1 35
  • 83.66 (n)
  • 75.48 (a)
COBLL1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COBLL1 35
  • 83.91 (n)
  • 77.37 (a)
COBLL1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cobll1 35
  • 74.36 (n)
  • 66.76 (a)
Cobll1 16
Cobll1 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COBLL1 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COBLL1 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cobll1 35
  • 75.68 (n)
  • 67.16 (a)
chicken
(Gallus gallus)
Aves COBLL1 35
  • 60.45 (n)
  • 50.22 (a)
COBLL1 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cobll1 35
  • 54.54 (n)
  • 45.69 (a)
zebrafish
(Danio rerio)
Actinopterygii COBLL1 (1 of 2) 36
  • 59 (a)
OneToMany
COBLL1 (2 of 2) 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6479 36
  • 29 (a)
OneToMany
Species with no ortholog for COBLL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COBLL1 Gene

ENSEMBL:
Gene Tree for COBLL1 (if available)
TreeFam:
Gene Tree for COBLL1 (if available)

Paralogs for COBLL1 Gene

Paralogs for COBLL1 Gene

Selected SIMAP similar genes for COBLL1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with COBLL1: view

Variants for COBLL1 Gene

Sequence variations from dbSNP and Humsavar for COBLL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs50916 -- 164,752,143(+) TCTAT(C/G)CAGTA intron-variant
rs168544 -- 164,825,918(-) AACAA(A/G)AAATT intron-variant
rs168545 -- 164,833,174(-) gtcca(A/G)ctggt intron-variant
rs168546 -- 164,788,014(+) TTCCC(C/T)GGCCT intron-variant
rs171392 -- 164,764,954(-) tgttc(A/G)tcaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COBLL1 Gene

Variant ID Type Subtype PubMed ID
nsv517875 CNV Loss 19592680
esv2661884 CNV Deletion 23128226
nsv520658 CNV Loss 19592680
dgv163e55 CNV Gain 17911159
nsv875366 CNV Loss 21882294
esv2642304 CNV Deletion 19546169
esv2045841 CNV Deletion 18987734

Relevant External Links for COBLL1 Gene

HapMap Linkage Disequilibrium report
COBLL1
Human Gene Mutation Database (HGMD)
COBLL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COBLL1 Gene

Disorders for COBLL1 Gene

Relevant External Links for COBLL1

Genetic Association Database (GAD)
COBLL1
Human Genome Epidemiology (HuGE) Navigator
COBLL1
genes like me logo Genes that share disorders with COBLL1: view

No data available for UniProtKB/Swiss-Prot for COBLL1 Gene

Publications for COBLL1 Gene

  1. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 48
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48
  4. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 48
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4

Products for COBLL1 Gene

  • antibodies-online peptides for COBLL1
  • antibodies-online antibodies for COBLL1
  • antibodies-online kits for COBLL1

Sources for COBLL1 Gene

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