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Aliases for COBL Gene

Aliases for COBL Gene

  • Cordon-Bleu WH2 Repeat Protein 2 3 5
  • Cordon-Bleu Homolog (Mouse) 2
  • KIAA0633 4

External Ids for COBL Gene

Previous GeneCards Identifiers for COBL Gene

  • GC07M050548
  • GC07M050791
  • GC07M050825
  • GC07M050858
  • GC07M051051
  • GC07M050933

Summaries for COBL Gene

GeneCards Summary for COBL Gene

COBL (Cordon-Bleu WH2 Repeat Protein) is a Protein Coding gene. GO annotations related to this gene include actin binding and actin monomer binding. An important paralog of this gene is COBLL1.

UniProtKB/Swiss-Prot for COBL Gene

  • Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COBL Gene

Genomics for COBL Gene

Regulatory Elements for COBL Gene

Enhancers for COBL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COBL on UCSC Golden Path with GeneCards custom track

Promoters for COBL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COBL on UCSC Golden Path with GeneCards custom track

Genomic Location for COBL Gene

Chromosome:
7
Start:
51,016,212 bp from pter
End:
51,316,818 bp from pter
Size:
300,607 bases
Orientation:
Minus strand

Genomic View for COBL Gene

Genes around COBL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COBL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COBL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COBL Gene

Proteins for COBL Gene

  • Protein details for COBL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75128-COBL_HUMAN
    Recommended name:
    Protein cordon-bleu
    Protein Accession:
    O75128
    Secondary Accessions:
    • A4D257
    • A7E2B0
    • B7ZLW9
    • B9EGF8
    • Q2T9J3
    • Q504Y4
    • Q86XA7
    • Q8N304
    • Q8TCM1

    Protein attributes for COBL Gene

    Size:
    1261 amino acids
    Molecular mass:
    135617 Da
    Quaternary structure:
    • Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X. Interacts (via WH2 domains) with actin monomers. Interacts with both PACSIN1 and DBNL. Identified in a complex composed of COBL, PACSIN1 and WASL. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity).
    SequenceCaution:
    • Sequence=BAA31608.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COBL Gene

    Alternative splice isoforms for COBL Gene

neXtProt entry for COBL Gene

Proteomics data for COBL Gene at MOPED

Post-translational modifications for COBL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COBL Gene

Domains & Families for COBL Gene

Protein Domains for COBL Gene

Suggested Antigen Peptide Sequences for COBL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75128

UniProtKB/Swiss-Prot:

COBL_HUMAN :
  • Contains 3 WH2 domains.
Domain:
  • Contains 3 WH2 domains.
genes like me logo Genes that share domains with COBL: view

No data available for Gene Families for COBL Gene

Function for COBL Gene

Molecular function for COBL Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles.
genes like me logo Genes that share phenotypes with COBL: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COBL Gene

Localization for COBL Gene

Subcellular locations from UniProtKB/Swiss-Prot for COBL Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm. Note=Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COBL Gene COMPARTMENTS Subcellular localization image for COBL gene
Compartment Confidence
cytoskeleton 4
nucleus 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for COBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA,ISS --
GO:0005886 plasma membrane ISS --
GO:0016020 colocalizes_with membrane IEA,ISS --
GO:0030425 dendrite IEA,ISS --
GO:0043025 neuronal cell body IEA,ISS --
genes like me logo Genes that share ontologies with COBL: view

Pathways & Interactions for COBL Gene

SuperPathways for COBL Gene

No Data Available

Interacting Proteins for COBL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265136%0d%0a9606.ENSP00000264993%0d%0a9606.ENSP00000244458%0d%0a
Selected Interacting proteins: ENSP00000265136 O75128-COBL_HUMAN for COBL Gene via STRING I2D

Gene Ontology (GO) - Biological Process for COBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001757 somite specification IEA,ISS --
GO:0001843 neural tube closure IEA,ISS --
GO:0001889 liver development IEA,ISS --
GO:0030041 actin filament polymerization IEA,ISS --
GO:0033504 floor plate development IEA,ISS --
genes like me logo Genes that share ontologies with COBL: view

No data available for Pathways by source and SIGNOR curated interactions for COBL Gene

Drugs & Compounds for COBL Gene

No Compound Related Data Available

Transcripts for COBL Gene

Unigene Clusters for COBL Gene

Cordon-bleu WH2 repeat protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COBL Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for COBL Gene

GeneLoc Exon Structure for
COBL
ECgene alternative splicing isoforms for
COBL

Expression for COBL Gene

mRNA expression in normal human tissues for COBL Gene

Protein differential expression in normal tissues from HIPED for COBL Gene

This gene is overexpressed in Serum (22.0), Heart (15.4), and Plasma (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COBL Gene



SOURCE GeneReport for Unigene cluster for COBL Gene Hs.99141

genes like me logo Genes that share expression patterns with COBL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for COBL Gene

Orthologs for COBL Gene

This gene was present in the common ancestor of chordates.

Orthologs for COBL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COBL 35
  • 71.97 (n)
  • 64.07 (a)
COBL 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COBL 35
  • 71.59 (n)
  • 66.47 (a)
COBL 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cobl 35
  • 74.66 (n)
  • 68.49 (a)
Cobl 16
Cobl 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COBL 35
  • 99.08 (n)
  • 98.51 (a)
COBL 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cobl 35
  • 72.51 (n)
  • 65.44 (a)
oppossum
(Monodelphis domestica)
Mammalia COBL 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COBL 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves COBL 35
  • 59.07 (n)
  • 51.95 (a)
COBL 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COBL 36
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cobl 35
  • 57.1 (n)
  • 50 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52972 35
zebrafish
(Danio rerio)
Actinopterygii cobl 36
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6479 36
  • 27 (a)
OneToMany
Species with no ortholog for COBL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COBL Gene

ENSEMBL:
Gene Tree for COBL (if available)
TreeFam:
Gene Tree for COBL (if available)

Paralogs for COBL Gene

Paralogs for COBL Gene

(1) SIMAP similar genes for COBL Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for COBL Gene

genes like me logo Genes that share paralogs with COBL: view

Variants for COBL Gene

Sequence variations from dbSNP and Humsavar for COBL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10230120 - 51,029,366(+) GGGAG(G/T)CTCTC reference, missense
rs2240090 - 51,029,277(+) TCCGA(A/C/T)GTCAT reference, missense
rs17134128 - 51,028,317(+) ACCAT(C/T)CTTCC reference, missense
rs17134127 - 51,028,053(+) AGGTG(C/G/T)GCGTC reference, missense
rs17656599 - 51,029,519(+) CCTGT(A/G)GGCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for COBL Gene

Variant ID Type Subtype PubMed ID
nsv830999 CNV Gain 17160897
esv2734386 CNV Deletion 23290073
esv2734387 CNV Deletion 23290073
esv2734388 CNV Deletion 23290073
esv2734389 CNV Deletion 23290073
nsv516294 CNV Gain 19592680
nsv5739 CNV Insertion 18451855
esv1975196 CNV Deletion 18987734
esv2734390 CNV Deletion 23290073
nsv5740 CNV Insertion 18451855
nsv831000 CNV Gain 17160897
esv2734391 CNV Deletion 23290073
dgv1132e201 CNV Deletion 23290073
nsv366189 CNV Loss 16902084

Variation tolerance for COBL Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COBL Gene

Disorders for COBL Gene

Relevant External Links for COBL

Genetic Association Database (GAD)
COBL
Human Genome Epidemiology (HuGE) Navigator
COBL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COBL

No disorders were found for COBL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COBL Gene

Publications for COBL Gene

  1. Cordon-Bleu uses WH2 domains as multifunctional dynamizers of actin filament assembly. (PMID: 21816349) Husson C. … Carlier M.F. (Mol. Cell 2011) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. (PMID: 26334624) Hou W. … Qualmann B. (PLoS Biol. 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3

Products for COBL Gene

Sources for COBL Gene

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