External Ids for COBL Gene
Previous GeneCards Identifiers for COBL Gene
GeneCards Summary for COBL Gene
COBL (Cordon-Bleu WH2 Repeat Protein) is a Protein Coding gene. GO annotations related to this gene include actin monomer binding. An important paralog of this gene is COBLL1.
UniProtKB/Swiss-Prot for COBL Gene
Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles.