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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COASY Gene

protein-coding GIFtS: 59
GCID: GC17P040714

CoA synthase

(Previous name: Coenzyme A synthase )

Explore 6 diseases affiliated with
COASY via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CoA Synthase¹ ² ³		Bifunctional Coenzyme A Synthase²
NBP¹ ² ³		Bifunctional Phosphopantetheine Adenylyl Transferase/Dephospho CoA Kinase²
DPCK¹ ²		Nucleotide Binding Protein²
PPAT¹ ²		POV-2³
CoASY¹		Phosphopantetheine Adenylyltransferase / Dephosphocoenzyme A Kinase²
Coenzyme A Synthase¹		POV-2³
UKR1²

External Ids:	HGNC: 29932¹	Entrez Gene: 80347²	Ensembl: ENSG00000068120⁷	OMIM: 609855⁵	UniProtKB: Q13057³

Export aliases for COASY gene to outside databases

Previous GC identifers: GC17P041088 GC17P037967 GC17P036478

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COASY:

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes

and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis. These activities are

performed by 2 separate enzymes, phosphopantetheine adenylyltransferase (PPAT; EC 2.7.7.3) and dephospho-CoA kinase

(DPCK; EC 2.7.1.24), in prokaryotes (Daugherty et al., 2002 (PubMed 11923312)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: COASY_HUMAN, Q13057

Function: Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The

fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth

reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis

regulation

Gene Wiki entry for COASY

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COASY gene promoter:
Egr-3 PPAR-gamma1 Pax-6 Pax-2a PPAR-gamma2 C/EBPalpha HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COASY promoter sequence

Search SABiosciences Chromatin IP Primers for COASY

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COASY

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12-q21

COASY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COASY gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P040714: view genomic region (about GC identifiers)

Start:	40,713,485 bp from pter	End:	40,718,295 bp from pter
Size:	4,811 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COASY_HUMAN, Q13057 (See protein sequence)

Recommended Name: Bifunctional coenzyme A synthase

Size: 564 amino acids; 62329 Da

Subunit: Monomer

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=AAA69699.1; Type=Frameshift; Positions=535; Sequence=AAF87955.1; Type=Erroneous initiation;

Sequence=AAH06354.1; Type=Erroneous initiation; Sequence=AAH20985.1; Type=Erroneous initiation; Sequence=AK075415;

Type=Frameshift; Positions=315;

Secondary accessions: B2RA78 B4DLU0 Q6GS23 Q8NBM7 Q8NEW1 Q8WXD4 Q9NRM3

Alternative splicing: 2 isoforms: Q13057-1 Q13057-2

Explore the universe of human proteins at neXtProt for COASY: NX_Q13057

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13057

COASY Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001035994.1 NP_001035997.2 NP_079509.5

ENSEMBL proteins:

ENSP00000467174 ENSP00000467519 ENSP00000466838 ENSP00000393564 ENSP00000467687

ENSP00000468755 ENSP00000468583 ENSP00000467322 ENSP00000464814 ENSP00000377406

ENSP00000413338 ENSP00000407740

Reactome Protein details: Q13057
Human Recombinant Protein Products for COASY:

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	OriGene Purified Proteins (see all 4): COASY OriGene Protein Over-expression Lysate (see all 6): COASY OriGene Custom Protein Services for COASY
	GenScript Custom Purified and Recombinant Proteins Services for COASY
	Novus Biologicals COASY Proteins Novus Biologicals COASY Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for COASY

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005741	mitochondrial outer membrane	TAS	--

COASY for ontologies About GeneDecksing

COASY Antibody Products:

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	Uscn Antibodies for COASY
	ThermoFisher Antibodies for COASY

Assay Products for COASY:

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	Uscn ELISAs and CLIAs for COASY

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COASY for domains About GeneDecksing

3 InterPro domains/families:

IPR004821 Cyt_trans-like

IPR001977 Depp_CoAkinase

IPR014729 Rossmann-like_a/b/a_fold

Graphical View of Domain Structure for InterPro Entry Q13057

ProtoNet protein and cluster: Q13057

2 Blocks protein families:

IPB001977 Dephospho-CoA kinase

IPB004820 Cytidylyltransferase

UniProtKB/Swiss-Prot: COASY_HUMAN, Q13057

Similarity: In the central section; belongs to the eukaryotic coaD family

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: COASY_HUMAN, Q13057

Function: Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The

fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth

reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis

regulation

Catalytic activity: ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA

Catalytic activity: ATP + 3'-dephospho-CoA = ADP + CoA

Biophysicochemical properties: Kinetic parameters: KM=7.6 mM for 4'-phoshopantetheine; KM=145 mM for ATP (in the PPAT

reaction); KM=16.7 mM for dephospho-CoA; KM=34.4 mM for ATP (in the DPCK reaction);

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004140	dephospho-CoA kinase activity	IDA	11994049
GO:0004595	pantetheine-phosphate adenylyltransferase activity	IDA	11994049
GO:0005524	ATP binding	IEA	--

COASY for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for COASY:

Decreased CYP1A1 activity afte

Decreased Hepatitis C virus re

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for COASY

miRNA Products:		miRTarBase miRNAs that target COASY: hsa-mir-125b (MIRT005010)

		OriGene 3'-UTR Clone (see all 5): COASY Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COASY
		1 QIAGEN miScript miRNA Assays for microRNA that regulate COASY:
		hsa-miR-3926
		SwitchGear 3'UTR luciferase reporter plasmid: COASY 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COASY (see all 7) OriGene shRNA RFP: COASY OriGene siRNA: COASY
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		Sirion Biotech Custom design and validation of potent shRNA sequences against COASY

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for COASY
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COASY (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COASY (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): COASY (NM_001042529)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COASY

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COASY
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COASY

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Vitamin B5 (pantothenate) metabolism

Vitamin B5 (pantothenate) metabolism	1.00	coenzyme A biosynthesis	0.27
Coenzyme A biosynthesis	0.73	Metabolism of water-soluble vitamins and cofactors	0.21
Pantothenate and CoA biosynthesis	0.40	Metabolism of vitamins and cofactors	0.21

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for COASY

coenzyme A biosynthesis

5 Reactome Pathways for COASY

	Coenzyme A biosynthesis
	Metabolism
	Metabolism of vitamins and cofactors
	Vitamin B5 (pantothenate) metabolism
	Metabolism of water-soluble vitamins and cofactors

2 Kegg Pathways (Kegg details for COASY):

	Pantothenate and CoA biosynthesis
	Metabolic pathways

UniProtKB/Swiss-Prot: COASY_HUMAN, Q13057

Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5

Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5

COASY for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for COASY

5/6 Interacting proteins for COASY (Q13057^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPS6KB1	P23443²^,³	MINT-51122 MINT-51123 MINT-51062 MINT-51063 I2D: score=4
KRT20	P35900²^,³	MINT-66751 I2D: score=5
RPS6KB2	Q9UBS0²^,³	MINT-51121 I2D: score=3
EDC4	Q6P2E9²	MINT-8392060 MINT-8392081 MINT-8392048
C12orf4	Q9NQ89³	I2D: score=5

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006766	vitamin metabolic process	TAS	--
GO:0006767	water-soluble vitamin metabolic process	TAS	--
GO:0009108	coenzyme biosynthetic process	TAS	--
GO:0015937	coenzyme A biosynthetic process	TAS	11994049
GO:0015939	pantothenate metabolic process	TAS	--

COASY for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

COASY for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COASY

7 HMDB Compounds for COASY About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--
Dephospho-CoA	3'-O-dephosphono-Coenzyme A (see all 7)	3633-59-8	--
Pantetheine 4'-phosphate	4'-Phosphopantetheine (see all 8)	2226-71-3	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

3 Novoseek chemical compound relationships for COASY gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dephospho coa	97.2	9	17603993 (2), 19763791 (1), 12837781 (1), 14684928 (1) (see all 5)
4'-phosphopantetheine	90.7	11	12837781 (3), 14684928 (3), 19763791 (1), 14514684 (1)
phosphatidylcholine	38.2	1	14514684 (1)

Search CenterWatch for drugs/clinical trials and news about COASY

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COASY gene (5 alternative transcripts):

NM_001042530.1 NM_001042531.1 NM_001042529.2 NM_001042532.3 NM_025233.6

Unigene Cluster for COASY:

CoA synthase

Hs.296422 [show with all ESTs]

Unigene Representative Sequence: NM_025233

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000588757 ENST00000585811 ENST00000585909 ENST00000586771 ENST00000421097

ENST00000591779 ENST00000587858 ENST00000587214 ENST00000587157 ENST00000590958

ENST00000393818(uc002iad.3) ENST00000591753 ENST00000588353 ENST00000591583

ENST00000420359(uc010cyj.3 uc002hzz.3 uc002iac.3) ENST00000449624(uc002iab.3 uc002iae.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 5): COASY Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COASY
		1 QIAGEN miScript miRNA Assays for microRNA that regulate COASY:
		hsa-miR-3926
		SwitchGear 3'UTR luciferase reporter plasmid: COASY 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 5): COASY (NM_001042529)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COASY

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COASY

Additional cDNA sequence:

AF208536.1 AF453478.1 AK075415.1 AK092498.1 AK225485.1 AK297153.1 AK303766.1 AK314076.1

AL360167.1 AL360168.1 AL833588.1 AY094602.1 BC006354.1 BC020985.1 BC067254.1 BT007168.1

U18919.1

21 DOTS entries:

DT.95291387 DT.316359 DT.100831029 DT.316358 DT.100831031 DT.91992863 DT.120973659 DT.75200326

DT.86859628 DT.97860125 DT.100831030 DT.101974666 DT.95291370 DT.100701320 DT.100831026 DT.120973609

DT.120973664 DT.75200328 DT.86857961 DT.100038371 DT.443498

24/808 AceView cDNA sequences (see all 808):

AA573920 CR606467 AA378725 BM909674 BM829775 BM990242 BU736785 CB529405

BI334588 BP342834 BP429598 F21620 AA618577 BE883187 BU737373 BM722801

BQ051802 CA426564 BQ718106 CD722948 AA351646 BQ065587 AI688675 BI522713

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for COASY (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13
SP1:							-		-
SP2:
SP3:
SP4:							-		-		-		-
SP5:							-

ECgene alternative splicing isoforms for COASY

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COASY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGACTCTT

About this image
See COASY Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COASY

SOURCE GeneReport for Unigene cluster: Hs.296422

UniProtKB/Swiss-Prot: COASY_HUMAN, Q13057

Tissue specificity: Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen,

kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood

leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain

SABiosciences Custom PCR Arrays for COASY

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COASY
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COASY

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COASY

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for COASY gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Coasy^{1 , 5}	Coenzyme A synthase^{1, 5}	85.54(n)¹ 87.5(a)¹		11 (64.17 cM)⁵ 71743¹ NM_027896.4¹ NP_082172.2¹ 101082565⁵
lizard (Anolis carolinensis)	Reptilia	COASY⁶	--	60(a)	1 ↔ 1	6(72935642-72950941)
zebrafish (Danio rerio)	Actinopterygii	Dr.17697²	Transcribed sequence with weak similarity to protein more	77.66(n)		CK027190.1
fruit fly (Drosophila melanogaster)	Insecta	Ppat-Dpck¹	Bifunctional Phosphopantetheine adenylyltransferase more	50.33(n) 40.2(a)		38647 NM_139728.2 NP_647985.1
worm (Caenorhabditis elegans)	Secernentea	Y65B4A.8¹	Protein Y65B4A.8	47.3(n) 39.46(a)		171657 NM_058365.5 NP_490766.2
thale cress (Arabidopsis thaliana)	eudicotyledons	COAD¹	phosphopantetheine adenylyltransferase	48.03(n) 38.16(a)		816341 NM_127383.2 NP_179417.1
rice (Oryza sativa)	Liliopsida	Os07g0179400¹	hypothetical protein	45.78(n) 36.14(a)		4342557 NM_001065570.1 NP_001059035.1

ENSEMBL Gene Tree for COASY (if available)
TreeFam Gene Tree for COASY (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111683625^1,2		--	40712127(+)	`GTAGCC/TGGAAT`	3	--	us2k¹		1		CSA	2
rs186631005^1,2		--	40712183(+)	`AGAGAC/TGGGGT`	3	--	us2k¹		0	--	--	--	--
rs141668781^1,2		--	40712197(+)	`ACTATA/GTTGGC`	3	--	us2k¹		0	--	--	--	--
rs191831643^1,2		--	40712286(+)	`CACCGC/TGCCTG`	3	--	us2k¹		0	--	--	--	--
rs184629852^1,2		--	40712299(+)	`CATGTA/GTTATA`	3	--	us2k¹		0	--	--	--	--
rs147052952^1,2		--	40712333(+)	`CCTGTA/CTGCAA`	3	--	us2k¹		0	--	--	--	--
rs189750610^1,2		--	40712345(+)	`CCCAAG/TACACA`	3	--	us2k¹		0	--	--	--	--
rs16967862^1,2	C,F,H	--	40712360(+)	`ACTCTA/GTACCC`	3	--	us2k¹		9		NA NS EA WA	676
rs181852718^1,2		--	40712396(+)	`TCACTG/TGTCCA`	3	--	us2k¹		0	--	--	--	--
rs621141^1,2	C,F,H	--	40712417(+)	`AGGCAC/GTAAAA`	3	--	us2k¹		17		MN NS EA NA WA CSA	859

HapMap Linkage Disequilibrium report for COASY (40713485 - 40718295 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COASY: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COASY

DNA2.0 Custom Variant and Variant Library Synthesis for COASY

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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COASY for disorders           About GeneDecksing

OMIM gene information: 609855    OMIM disorders: --

6 diseases for COASY:    About MalaCards

gout breast cancer pneumonia tuberculosis

malaria mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: COASY (2 documents)

Export disorders for COASY gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for COASY gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with COASY)

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Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. (PubMed id 11923312)^{1, 2, 3} Daugherty M....Osterman A. (2002)
Identification of a novel CoA synthase isoform, which is primarily expressed in the brain. (PubMed id 16460672)^{1, 2} Nemazanyy I....Gout I.T. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase). (PubMed id 11994049)^{1, 2} Aghajanian S. and Worrall D.M. (2002)
Molecular cloning of CoA Synthase. The missing link i n CoA biosynthesis. (PubMed id 11980892)^{1, 3} Zhyvoloup A....Gout I.T. (2002)
A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase. (PubMed id 8529999)^{1, 2} Montagna M.... Lenoir G.M. (1995)
Subcellular localization and regulation of coenzyme A synthase. (PubMed id 14514684)^{1, 9} Zhyvoloup A....Gout I.T. (2003)
CoA synthase is in complex with p85alphaPI3K and affe cts PI3K signaling pathway. (PubMed id 19482007)^{1, 9} Breus O....Nemazanyy I. (2009)
Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism. (PubMed id 15589845)^{1, 9} Nemazanyy I....Filonenko V. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 80347	HGNC: 29932	AceView: COASYandTCFL4	Ensembl:ENSG00000068120	euGenes: HUgn80347
ECgene: COASY	Kegg: 80347	H-InvDB: COASY

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for COASY	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COASY gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for COASY gene:
Search GeneIP for patents involving COASY

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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