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Aliases for COA7 Gene

Aliases for COA7 Gene

  • Cytochrome C Oxidase Assembly Factor 7 (Putative) 2 3 5
  • Respiratory Chain Assembly Factor 1 3 4
  • Sel1 Repeat-Containing Protein 1 3 4
  • Beta-Lactamase Hcp-Like Protein 3 4
  • Respiratory Chain Assembly 1 2 3
  • Sel1 Repeat Containing 1 2 3
  • C1orf163 3 4
  • SELRC1 3 4
  • RESA1 3 4
  • Hcp Beta-Lactamase-Like Protein C1orf163 3
  • Cytochrome C Oxidase Assembly Factor 7 2
  • Chromosome 1 Open Reading Frame 163 2

External Ids for COA7 Gene

Previous HGNC Symbols for COA7 Gene

  • C1orf163
  • SELRC1

Previous GeneCards Identifiers for COA7 Gene

  • GC01M053154

Summaries for COA7 Gene

GeneCards Summary for COA7 Gene

COA7 (Cytochrome C Oxidase Assembly Factor 7 (Putative)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COA7 Gene

  • Required for assembly of mitochondrial respiratory chain complex I and complex IV.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COA7 Gene

Genomics for COA7 Gene

Regulatory Elements for COA7 Gene

Promoters for COA7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COA7 on UCSC Golden Path with GeneCards custom track

Genomic Location for COA7 Gene

52,684,451 bp from pter
52,698,366 bp from pter
13,916 bases
Minus strand

Genomic View for COA7 Gene

Genes around COA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COA7 Gene

Proteins for COA7 Gene

  • Protein details for COA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase assembly factor 7
    Protein Accession:
    Secondary Accessions:
    • Q0P6I7
    • Q9H9Z9

    Protein attributes for COA7 Gene

    231 amino acids
    Molecular mass:
    25709 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COA7 Gene

Proteomics data for COA7 Gene at MOPED

Post-translational modifications for COA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COA7 Gene

Domains & Families for COA7 Gene

Protein Domains for COA7 Gene


Suggested Antigen Peptide Sequences for COA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the hcp beta-lactamase family.
  • Contains 5 Sel1-like repeats.
  • Belongs to the hcp beta-lactamase family.
  • Contains 5 Sel1-like repeats.
genes like me logo Genes that share domains with COA7: view

Function for COA7 Gene

Molecular function for COA7 Gene

UniProtKB/Swiss-Prot Function:
Required for assembly of mitochondrial respiratory chain complex I and complex IV.

Phenotypes for COA7 Gene

genes like me logo Genes that share phenotypes with COA7: view

Animal Model Products

miRNA for COA7 Gene

miRTarBase miRNAs that target COA7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COA7 Gene

Localization for COA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COA7 Gene

Mitochondrion intermembrane space.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for COA7 Gene

Pathways & Interactions for COA7 Gene

SuperPathways for COA7 Gene

No Data Available

Interacting Proteins for COA7 Gene

Gene Ontology (GO) - Biological Process for COA7 Gene


No data available for Pathways by source and SIGNOR curated interactions for COA7 Gene

Drugs & Compounds for COA7 Gene

No Compound Related Data Available

Transcripts for COA7 Gene

mRNA/cDNA for COA7 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for COA7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for COA7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COA7 Gene

mRNA expression in normal human tissues for COA7 Gene

Protein differential expression in normal tissues from HIPED for COA7 Gene

This gene is overexpressed in Serum (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for COA7 Gene

genes like me logo Genes that share expression patterns with COA7: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for COA7 Gene

Orthologs for COA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for COA7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SELRC1 35
  • 88.74 (n)
  • 90.04 (a)
COA7 36
  • 90 (a)
(Canis familiaris)
Mammalia SELRC1 35
  • 89.47 (n)
  • 91.34 (a)
COA7 36
  • 91 (a)
(Mus musculus)
Mammalia Coa7 35
  • 86.15 (n)
  • 90.48 (a)
Coa7 16
Selrc1 36
  • 90 (a)
(Pan troglodytes)
Mammalia SELRC1 35
  • 99.71 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Selrc1 35
  • 84.85 (n)
  • 90.04 (a)
(Monodelphis domestica)
Mammalia COA7 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia COA7 36
  • 76 (a)
(Gallus gallus)
Aves SELRC1 35
  • 71.01 (n)
  • 65.65 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia COA7 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia coa7 35
  • 65.22 (n)
  • 64.78 (a)
Str.15655 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3290 35
(Danio rerio)
Actinopterygii coa7 35
  • 64.04 (n)
  • 60.96 (a)
selrc1 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13865 35
  • 52.1 (n)
  • 37.84 (a)
CG13865 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea ZK20.4 35
  • 47.96 (n)
  • 33.49 (a)
ZK20.4 36
  • 29 (a)
Species with no ortholog for COA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COA7 Gene

Gene Tree for COA7 (if available)
Gene Tree for COA7 (if available)

Paralogs for COA7 Gene

No data available for Paralogs for COA7 Gene

Variants for COA7 Gene

Sequence variations from dbSNP and Humsavar for COA7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs443751 - 52,687,760(-) ACACA(A/G)AGAAC reference, missense
rs366309 -- 52,688,436(-) ATCCT(G/T)TCTCT intron-variant
rs392350 -- 52,692,075(+) agagg(C/T)ctctg intron-variant
rs448788 -- 52,695,948(+) AAGCC(C/T)TGACA intron-variant
rs374662 -- 52,698,877(-) TGTGT(G/T)CCAGT upstream-variant-2KB

Variation tolerance for COA7 Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.78; 83.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COA7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COA7 Gene

Disorders for COA7 Gene

Relevant External Links for COA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COA7 Gene

Publications for COA7 Gene

  1. C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly. (PMID: 24333015) Kozjak-Pavlovic V. … Rudel T. (J. Mol. Biol. 2014) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  5. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. (PMID: 22114354) Alkhaja A.K. … Deckers M. (Mol. Biol. Cell 2012) 3

Products for COA7 Gene

Sources for COA7 Gene

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