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Aliases for COA4 Gene

Aliases for COA4 Gene

  • Cytochrome C Oxidase Assembly Factor 4 Homolog 2 3
  • Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 8 3 4
  • Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 8 2 3
  • E2-Induced Gene 2 Protein 3 4
  • CHCHD8 3 4
  • E2IG2 3 4
  • Cytochrome C Oxidase Assembly Factor 4 Homolog (S. Cerevisiae) 2
  • CMC3 3

External Ids for COA4 Gene

Previous HGNC Symbols for COA4 Gene

  • CHCHD8

Previous GeneCards Identifiers for COA4 Gene

  • GC11M073584

Summaries for COA4 Gene

GeneCards Summary for COA4 Gene

COA4 (Cytochrome C Oxidase Assembly Factor 4 Homolog) is a Protein Coding gene. Diseases associated with COA4 include leigh syndrome.

UniProtKB/Swiss-Prot for COA4 Gene

  • Putative COX assembly factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COA4 Gene

Genomics for COA4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COA4 Gene

Chromosome:
11
Start:
73,872,667 bp from pter
End:
73,876,988 bp from pter
Size:
4,322 bases
Orientation:
Minus strand

Genomic View for COA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COA4 Gene

No data available for Regulatory Elements for COA4 Gene

Proteins for COA4 Gene

  • Protein details for COA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYJ1-COA4_HUMAN
    Recommended name:
    Cytochrome c oxidase assembly factor 4 homolog, mitochondrial
    Protein Accession:
    Q9NYJ1
    Secondary Accessions:
    • B2RAA0
    • Q69YU4

    Protein attributes for COA4 Gene

    Size:
    87 amino acids
    Molecular mass:
    10134 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for COA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COA4 Gene

Proteomics data for COA4 Gene at MOPED

Post-translational modifications for COA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COA4 Gene

No data available for DME Specific Peptides for COA4 Gene

Domains & Families for COA4 Gene

Protein Domains for COA4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for COA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYJ1

UniProtKB/Swiss-Prot:

COA4_HUMAN :
  • Contains 1 CHCH domain.
  • Belongs to the COA4 family.
Domain:
  • Contains 1 CHCH domain.
Family:
  • Belongs to the COA4 family.
genes like me logo Genes that share domains with COA4: view

Function for COA4 Gene

Molecular function for COA4 Gene

UniProtKB/Swiss-Prot Function:
Putative COX assembly factor.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estrogen.
genes like me logo Genes that share phenotypes with COA4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COA4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for COA4 Gene

Localization for COA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COA4 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COA4 Gene COMPARTMENTS Subcellular localization image for COA4 gene
Compartment Confidence
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for COA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005758 mitochondrial intermembrane space IBA --
genes like me logo Genes that share ontologies with COA4: view

Pathways & Interactions for COA4 Gene

SuperPathways for COA4 Gene

No Data Available

Interacting Proteins for COA4 Gene

Gene Ontology (GO) - Biological Process for COA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033617 mitochondrial respiratory chain complex IV assembly IBA --
genes like me logo Genes that share ontologies with COA4: view

No data available for Pathways by source and SIGNOR curated interactions for COA4 Gene

Drugs & Compounds for COA4 Gene

No Compound Related Data Available

Transcripts for COA4 Gene

Unigene Clusters for COA4 Gene

Cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COA4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for COA4 Gene

GeneLoc Exon Structure for
COA4
ECgene alternative splicing isoforms for
COA4

Expression for COA4 Gene

mRNA expression in normal human tissues for COA4 Gene

Protein differential expression in normal tissues from HIPED for COA4 Gene

This gene is overexpressed in Bone (10.6), Heart (9.4), and Fetal Liver (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COA4 Gene



SOURCE GeneReport for Unigene cluster for COA4 Gene Hs.475387

genes like me logo Genes that share expression patterns with COA4: view

Protein tissue co-expression partners for COA4 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COA4 Gene

Orthologs for COA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COA4 36
  • 100 (a)
OneToOne
COA4 35
  • 100 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia COA4 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coa4 36
  • 87 (a)
OneToOne
Coa4 16
Coa4 35
  • 86.97 (n)
  • 87.36 (a)
oppossum
(Monodelphis domestica)
Mammalia COA4 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coa4 35
  • 88.12 (n)
  • 87.36 (a)
dog
(Canis familiaris)
Mammalia CHCHD8 35
  • 88.49 (n)
  • 85.71 (a)
cow
(Bos Taurus)
Mammalia CHCHD8 35
  • 86.67 (n)
  • 85 (a)
lizard
(Anolis carolinensis)
Reptilia COA4 36
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32879 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9065 35
zebrafish
(Danio rerio)
Actinopterygii BX088524.2 36
  • 42 (a)
OneToOne
Species with no ortholog for COA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COA4 Gene

ENSEMBL:
Gene Tree for COA4 (if available)
TreeFam:
Gene Tree for COA4 (if available)

Paralogs for COA4 Gene

No data available for Paralogs for COA4 Gene

Variants for COA4 Gene

Sequence variations from dbSNP and Humsavar for COA4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1670546 -- 73,874,128(-) gctat(A/T)acccc intron-variant
rs3210738 -- 73,873,676(-) GGCTG(A/G)GTGGT intron-variant
rs3210739 -- 73,873,657(-) CCTGT(A/G)GTCCC intron-variant
rs12278343 -- 73,872,916(+) GCTGA(A/G)AATGT utr-variant-3-prime
rs34155285 -- 73,874,015(+) TACCT(-/A)AAAAG intron-variant

Variation tolerance for COA4 Gene

Residual Variation Intolerance Score: 74.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COA4 Gene

HapMap Linkage Disequilibrium report
COA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COA4 Gene

Disorders for COA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COA4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leigh syndrome
  • leigh syndrome due to mitochondrial complex i deficiency
- elite association
Search COA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for COA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COA4
genes like me logo Genes that share disorders with COA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COA4 Gene

Publications for COA4 Gene

  1. Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor family. (PMID: 20624914) Bestwick M. … Winge D.R. (Mol. Cell. Biol. 2010) 2 67
  2. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PMID: 11085516) Charpentier A.H. … Aldaz C.M. (Cancer Res. 2000) 2 67
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 67

Products for COA4 Gene

Sources for COA4 Gene

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