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Aliases for COA3 Gene

Aliases for COA3 Gene

  • Cytochrome C Oxidase Assembly Factor 3 2 3
  • CCDC56 3 4 6
  • Mitochondrial Translation Regulation Assembly Intermediate Of Cytochrome C Oxidase Protein Of 12 KDa 3 4
  • Coiled-Coil Domain-Containing Protein 56 3 4
  • MITRAC12 3 4
  • Cytochrome C Oxidase Assembly Protein 3 Homolog, Mitochondrial 3
  • Cytochrome C Oxidase Assembly Factor 3 Homolog, Mitochondrial 3
  • Coiled-Coil Domain Containing 56 2
  • HSPC009 3

External Ids for COA3 Gene

Previous HGNC Symbols for COA3 Gene

  • CCDC56

Previous GeneCards Identifiers for COA3 Gene

  • GC17M040950

Summaries for COA3 Gene

Entrez Gene Summary for COA3 Gene

  • This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. [provided by RefSeq, Nov 2012]

GeneCards Summary for COA3 Gene

COA3 (Cytochrome C Oxidase Assembly Factor 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COA3 Gene

  • Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COA3 Gene

Genomics for COA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COA3 Gene

Start:
42,795,147 bp from pter
End:
42,798,725 bp from pter
Size:
3,579 bases
Orientation:
Minus strand

Genomic View for COA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COA3 Gene

No data available for Regulatory Elements for COA3 Gene

Proteins for COA3 Gene

  • Protein details for COA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2R0-COA3_HUMAN
    Recommended name:
    Cytochrome c oxidase assembly factor 3 homolog, mitochondrial
    Protein Accession:
    Q9Y2R0
    Secondary Accessions:
    • A8K498

    Protein attributes for COA3 Gene

    Size:
    106 amino acids
    Molecular mass:
    11731 Da
    Quaternary structure:
    • Component of some MITRAC complex.

neXtProt entry for COA3 Gene

Proteomics data for COA3 Gene at MOPED

Post-translational modifications for COA3 Gene

  • Ubiquitination at Lys48
  • Modification sites at PhosphoSitePlus

Other Protein References for COA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COA3 Gene

Domains for COA3 Gene

Gene Families for COA3 Gene

HGNC:
  • MITOAF :Mitochondrial respiratory chain complex assembly factors

Protein Domains for COA3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y2R0

UniProtKB/Swiss-Prot:

COA3_HUMAN :
  • Q9Y2R0
Family:
  • Belongs to the COA3 family.
genes like me logo Genes that share domains with COA3: view

No data available for Suggested Antigen Peptide Sequences for COA3 Gene

Function for COA3 Gene

Molecular function for COA3 Gene

UniProtKB/Swiss-Prot Function: Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.

Gene Ontology (GO) - Molecular Function for COA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23260140
genes like me logo Genes that share ontologies with COA3: view

Phenotypes for COA3 Gene

GenomeRNAi human phenotypes for COA3:
genes like me logo Genes that share phenotypes with COA3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COA3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COA3 Gene

Localization for COA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COA3 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for COA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0031305 integral component of mitochondrial inner membrane IDA 23260140
genes like me logo Genes that share ontologies with COA3: view

No data available for Subcellular locations from COMPARTMENTS for COA3 Gene

Pathways for COA3 Gene

SuperPathways for COA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033617 mitochondrial respiratory chain complex IV assembly IMP 23260140
GO:0070131 positive regulation of mitochondrial translation IMP 23260140
genes like me logo Genes that share ontologies with COA3: view

No data available for Pathways by source for COA3 Gene

Transcripts for COA3 Gene

mRNA/cDNA for COA3 Gene

Unigene Clusters for COA3 Gene

Cytochrome c oxidase assembly factor 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COA3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COA3 Gene

No ASD Table

Relevant External Links for COA3 Gene

GeneLoc Exon Structure for
COA3
ECgene alternative splicing isoforms for
COA3

Expression for COA3 Gene

mRNA expression in normal human tissues for COA3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COA3 Gene

SOURCE GeneReport for Unigene cluster for COA3 Gene Hs.16059

genes like me logo Genes that share expressions with COA3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COA3 Gene

Orthologs for COA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC56 35
  • 99.69 (n)
  • 100 (a)
CCDC56 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COA3 35
  • 84.76 (n)
  • 84.76 (a)
COA3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
OneToMany
CCDC56 35
  • 84.76 (n)
  • 85.71 (a)
CCDC56 36
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Coa3 35
  • 83.15 (n)
  • 81.32 (a)
Coa3 16
Coa3 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COA3 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coa3 35
  • 83.15 (n)
  • 83.52 (a)
lizard
(Anolis carolinensis)
Reptilia COA3 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc56 35
  • 64.63 (n)
  • 64.63 (a)
zebrafish
(Danio rerio)
Actinopterygii coa3 35
  • 61.11 (n)
  • 59.52 (a)
coa3 36
  • 53 (a)
OneToMany
COA3 (2 of 2) 36
  • 27 (a)
OneToMany
Species with no ortholog for COA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COA3 Gene

ENSEMBL:
Gene Tree for COA3 (if available)
TreeFam:
Gene Tree for COA3 (if available)

Paralogs for COA3 Gene

No data available for Paralogs for COA3 Gene

Variants for COA3 Gene

Relevant External Links for COA3 Gene

HapMap Linkage Disequilibrium report
COA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for COA3 Gene

Disorders for COA3 Gene

No disorders were found for COA3 Gene.

No data available for UniProtKB/Swiss-Prot for COA3 Gene

Publications for COA3 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase. (PMID: 22356826) Szklarczyk R. … Huynen M.A. (Genome Biol. 2012) 2 3
  4. Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial protein essential for cytochrome c oxidase function. (PMID: 22610097) Peralta S. … Garesse R. (J. Biol. Chem. 2012) 2 3
  5. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. (PMID: 23260140) Mick D.U. … Rehling P. (Cell 2012) 3 4

Products for COA3 Gene

Sources for COA3 Gene

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