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Aliases for COA1 Gene

Aliases for COA1 Gene

  • Cytochrome C Oxidase Assembly Factor 1 Homolog 2 3 5
  • Mitochondrial Translation Regulation Assembly Intermediate Of Cytochrome C Oxidase Protein Of 15 KDa 3 4
  • MITRAC15 3 4
  • C7orf44 3 4
  • Cytochrome C Oxidase Assembly Factor 1 Homolog (S. Cerevisiae) 2
  • Cytochrome C Oxidase Assembly Protein 1 Homolog 3
  • Chromosome 7 Open Reading Frame 44 2

External Ids for COA1 Gene

Previous HGNC Symbols for COA1 Gene

  • C7orf44

Previous GeneCards Identifiers for COA1 Gene

  • GC07M043648

Summaries for COA1 Gene

GeneCards Summary for COA1 Gene

COA1 (Cytochrome C Oxidase Assembly Factor 1 Homolog) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COA1 Gene

  • Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COA1 Gene

Genomics for COA1 Gene

Regulatory Elements for COA1 Gene

Promoters for COA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for COA1 Gene

Chromosome:
7
Start:
43,608,452 bp from pter
End:
43,729,717 bp from pter
Size:
121,266 bases
Orientation:
Minus strand

Genomic View for COA1 Gene

Genes around COA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COA1 Gene

Proteins for COA1 Gene

  • Protein details for COA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZY4-COA1_HUMAN
    Recommended name:
    Cytochrome c oxidase assembly factor 1 homolog
    Protein Accession:
    Q9GZY4
    Secondary Accessions:
    • A6NJU8
    • A8KAH8
    • Q9HAB7
    • Q9NVD2

    Protein attributes for COA1 Gene

    Size:
    146 amino acids
    Molecular mass:
    16694 Da
    Quaternary structure:
    • Interacts with COX17 and COA6. Component of some MITRAC complex.

neXtProt entry for COA1 Gene

Proteomics data for COA1 Gene at MOPED

Post-translational modifications for COA1 Gene

  • Ubiquitination at Lys 125
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COA1 Gene

Domains & Families for COA1 Gene

Protein Domains for COA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9GZY4

UniProtKB/Swiss-Prot:

COA1_HUMAN :
  • Belongs to the COA1 family.
Family:
  • Belongs to the COA1 family.
genes like me logo Genes that share domains with COA1: view

No data available for Suggested Antigen Peptide Sequences for COA1 Gene

Function for COA1 Gene

Molecular function for COA1 Gene

UniProtKB/Swiss-Prot Function:
Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV.

Phenotypes for COA1 Gene

GenomeRNAi human phenotypes for COA1:
genes like me logo Genes that share phenotypes with COA1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COA1 Gene

Localization for COA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COA1 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COA1 Gene COMPARTMENTS Subcellular localization image for COA1 gene
Compartment Confidence
mitochondrion 5
cytosol 4

Gene Ontology (GO) - Cellular Components for COA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0022625 cytosolic large ribosomal subunit IBA --
genes like me logo Genes that share ontologies with COA1: view

Pathways & Interactions for COA1 Gene

SuperPathways for COA1 Gene

No Data Available

Interacting Proteins for COA1 Gene

Gene Ontology (GO) - Biological Process for COA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
genes like me logo Genes that share ontologies with COA1: view

No data available for Pathways by source and SIGNOR curated interactions for COA1 Gene

Drugs & Compounds for COA1 Gene

No Compound Related Data Available

Transcripts for COA1 Gene

Unigene Clusters for COA1 Gene

Cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h ^
SP1: - - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: -
SP18: - - - - - - - - - - - - -
SP19: - - - - - - -
SP20: - - - - - - - - - - - - - -
SP21: - - - -
SP22: - - - - -
SP23:
SP24: - - - - - - - - - - - -
SP25: - -
SP26:

ExUns: 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c · 16d · 16e · 16f
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - - -
SP12: - -
SP13:
SP14: - - - - -
SP15:
SP16:
SP17:
SP18:
SP19: - - - -
SP20:
SP21:
SP22: - - - - -
SP23:
SP24:
SP25:
SP26: - - -

Relevant External Links for COA1 Gene

GeneLoc Exon Structure for
COA1
ECgene alternative splicing isoforms for
COA1

Expression for COA1 Gene

mRNA expression in normal human tissues for COA1 Gene

Protein differential expression in normal tissues from HIPED for COA1 Gene

This gene is overexpressed in Bone (22.8), Lung (13.6), Vitreous humor (8.7), and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for COA1 Gene



SOURCE GeneReport for Unigene cluster for COA1 Gene Hs.654779

genes like me logo Genes that share expression patterns with COA1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for COA1 Gene

Orthologs for COA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf44 35
  • 99.09 (n)
  • 97.95 (a)
C7ORF44 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FLJ10803 36
  • 71 (a)
OneToOne
COA1 35
  • 79.35 (n)
  • 71.64 (a)
dog
(Canis familiaris)
Mammalia COA1 35
  • 80.85 (n)
  • 68.66 (a)
COA1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COA1 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COA1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492393 35
  • 56.64 (n)
  • 46.34 (a)
zebrafish
(Danio rerio)
Actinopterygii rpl37 36
  • 40 (a)
OneToOne
Species with no ortholog for COA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COA1 Gene

ENSEMBL:
Gene Tree for COA1 (if available)
TreeFam:
Gene Tree for COA1 (if available)

Paralogs for COA1 Gene

Pseudogenes.org Pseudogenes for COA1 Gene

genes like me logo Genes that share paralogs with COA1: view

No data available for Paralogs for COA1 Gene

Variants for COA1 Gene

Sequence variations from dbSNP and Humsavar for COA1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs849160 -- 43,695,613(+) tgaat(A/G)gtgct intron-variant
rs849166 -- 43,720,607(+) aaaaa(A/T)cattg intron-variant
rs849167 -- 43,721,284(+) TTAAA(C/T)GTCAG intron-variant
rs849171 -- 43,725,098(+) ctagg(C/T)gtggt intron-variant
rs849172 -- 43,726,068(+) AAAAG(C/T)ACCTA intron-variant

Variation tolerance for COA1 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COA1 Gene

HapMap Linkage Disequilibrium report
COA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COA1 Gene

Disorders for COA1 Gene

Relevant External Links for COA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COA1

No disorders were found for COA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COA1 Gene

Publications for COA1 Gene

  1. Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase. (PMID: 22356826) Szklarczyk R. … Huynen M.A. (Genome Biol. 2012) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. (PMID: 23260140) Mick D.U. … Rehling P. (Cell 2012) 3
  4. E3 ligase RFWD3 participates in replication checkpoint control. (PMID: 21504906) Gong Z. … Chen J. (J. Biol. Chem. 2011) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for COA1 Gene

Sources for COA1 Gene

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