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Aliases for CNTROB Gene

Aliases for CNTROB Gene

  • Centrobin, Centriole Duplication And Spindle Assembly Protein 2 3 5
  • Centrobin, Centrosomal BRCA2 Interacting Protein 2 3
  • Centrosomal BRCA2-Interacting Protein 3 4
  • LYST-Interacting Protein 8 3 4
  • Centrobin 2 3
  • LIP8 3 4
  • LYST-Interacting Protein LIP8 3
  • PP1221 3

External Ids for CNTROB Gene

Previous GeneCards Identifiers for CNTROB Gene

  • GC17P007777
  • GC17P007835

Summaries for CNTROB Gene

Entrez Gene Summary for CNTROB Gene

  • This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CNTROB Gene

CNTROB (Centrobin, Centriole Duplication And Spindle Assembly Protein) is a Protein Coding gene. Diseases associated with CNTROB include Squamous Cell Papilloma and Salivary Gland Disease. GO annotations related to this gene include protein domain specific binding.

UniProtKB/Swiss-Prot for CNTROB Gene

  • Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.

Gene Wiki entry for CNTROB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTROB Gene

Genomics for CNTROB Gene

Regulatory Elements for CNTROB Gene

Enhancers for CNTROB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G007571 1.7 Ensembl ENCODE dbSUPER 32.8 -353.9 -353943 14.2 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF416 DVL2 PFAS ENSG00000265749 SNORD10 SNORA48 CTC1 CNTROB SAT2 ENSG00000262089 NLGN2
GH17G008137 1.7 Ensembl ENCODE dbSUPER 31.1 +207.4 207350 3.7 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 NFYC DVL2 PFAS ENSG00000265749 CTC1 SNORD10 CNTROB SENP3 SNORA48 KCTD11 NEURL4
GH17G008172 1.5 ENCODE dbSUPER 30.8 +242.9 242866 5.2 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 DVL2 PFAS SNORD10 CTC1 SNORA48 PER1 ENSG00000265749 CNTROB LOC100996842 RPL26
GH17G008185 1.5 ENCODE dbSUPER 29.7 +256.3 256283 5.8 MLX CREB3L1 AGO1 ZFP64 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 DVL2 PFAS CTC1 SNORD10 ENSG00000265749 SNORA48 CNTROB NEURL4 NLGN2 LOC100996842
GH17G008149 1.9 FANTOM5 ENCODE dbSUPER 21.8 +225.2 225218 16.0 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF416 ZNF143 ZNF263 DVL2 PER1 PFAS SENP3 CTC1 LOC100996842 ENSG00000265749 VAMP2 SNORD10 SNORA48
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNTROB on UCSC Golden Path with GeneCards custom track

Promoters for CNTROB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090922 199 2201 CREB3L1 MLX FEZF1 YY1 ZNF143 SP3 NFYC TBX21 ZNF610 ZNF585B

Genomic Location for CNTROB Gene

Chromosome:
17
Start:
7,932,101 bp from pter
End:
7,949,919 bp from pter
Size:
17,819 bases
Orientation:
Plus strand

Genomic View for CNTROB Gene

Genes around CNTROB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTROB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTROB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTROB Gene

Proteins for CNTROB Gene

  • Protein details for CNTROB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N137-CNTRB_HUMAN
    Recommended name:
    Centrobin
    Protein Accession:
    Q8N137
    Secondary Accessions:
    • A6NHQ1
    • Q331K3
    • Q69YV7
    • Q8NCB8
    • Q8WXV3
    • Q96CQ7
    • Q9C060

    Protein attributes for CNTROB Gene

    Size:
    903 amino acids
    Molecular mass:
    101253 Da
    Quaternary structure:
    • Interacts with LYST.
    SequenceCaution:
    • Sequence=AAG49447.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAG49447.1; Type=Frameshift; Positions=609; Evidence={ECO:0000305}; Sequence=BAC11241.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CNTROB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNTROB Gene

Post-translational modifications for CNTROB Gene

  • Ubiquitination at posLast=610610, posLast=761761, and Lys832
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNTROB Gene

Domains & Families for CNTROB Gene

Protein Domains for CNTROB Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CNTROB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CNTROB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CNTROB Gene

Function for CNTROB Gene

Molecular function for CNTROB Gene

UniProtKB/Swiss-Prot Function:
Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.

Gene Ontology (GO) - Molecular Function for CNTROB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16275750
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with CNTROB: view

Phenotypes for CNTROB Gene

genes like me logo Genes that share phenotypes with CNTROB: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNTROB Gene

Localization for CNTROB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTROB Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNTROB gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for CNTROB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IMP 21576394
GO:0005814 centriole IDA 16275750
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CNTROB: view

Pathways & Interactions for CNTROB Gene

SuperPathways for CNTROB Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTROB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007099 centriole replication IMP 16275750
GO:0051299 centrosome separation IMP 16275750
GO:0051301 cell division IEA --
GO:1902410 mitotic cytokinetic process IMP 16275750
genes like me logo Genes that share ontologies with CNTROB: view

No data available for Pathways by source and SIGNOR curated interactions for CNTROB Gene

Drugs & Compounds for CNTROB Gene

No Compound Related Data Available

Transcripts for CNTROB Gene

Unigene Clusters for CNTROB Gene

Centrobin, centrosomal BRCA2 interacting protein:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTROB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: -
SP2: -
SP3: -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CNTROB Gene

GeneLoc Exon Structure for
CNTROB
ECgene alternative splicing isoforms for
CNTROB

Expression for CNTROB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNTROB Gene

Protein differential expression in normal tissues from HIPED for CNTROB Gene

This gene is overexpressed in Bone marrow stromal cell (30.8) and Fetal testis (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNTROB Gene



NURSA nuclear receptor signaling pathways regulating expression of CNTROB Gene:

CNTROB

SOURCE GeneReport for Unigene cluster for CNTROB Gene:

Hs.348012

mRNA Expression by UniProt/SwissProt for CNTROB Gene:

Q8N137-CNTRB_HUMAN
Tissue specificity: Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for CNTROB Gene

  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CNTROB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNTROB Gene

Orthologs for CNTROB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNTROB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTROB 34 35
  • 99.63 (n)
rat
(Rattus norvegicus)
Mammalia Cntrob 34
  • 84.69 (n)
mouse
(Mus musculus)
Mammalia Cntrob 34 16 35
  • 84.63 (n)
dog
(Canis familiaris)
Mammalia CNTROB 34 35
  • 84.24 (n)
cow
(Bos Taurus)
Mammalia CNTROB 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNTROB 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNTROB 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNTROB 35
  • 44 (a)
OneToOne
Species where no ortholog for CNTROB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CNTROB Gene

ENSEMBL:
Gene Tree for CNTROB (if available)
TreeFam:
Gene Tree for CNTROB (if available)

Paralogs for CNTROB Gene

No data available for Paralogs for CNTROB Gene

Variants for CNTROB Gene

Sequence variations from dbSNP and Humsavar for CNTROB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000040924 -- 7,933,149(+) CAGAA(C/T)CCCCT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000162751 -- 7,932,392(+) GGCGG(C/T)GTGCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000189964 -- 7,939,211(+) CCTTT(A/G)CCTCC intron-variant
rs1000433162 -- 7,932,804(+) CAGTA(G/T)GTCTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000559967 -- 7,938,128(+) CTCCC(A/G)AGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNTROB Gene

Variant ID Type Subtype PubMed ID
esv2670156 CNV deletion 23128226
nsv457660 CNV loss 19166990
nsv574333 CNV loss 21841781

Variation tolerance for CNTROB Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNTROB Gene

Human Gene Mutation Database (HGMD)
CNTROB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNTROB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTROB Gene

Disorders for CNTROB Gene

MalaCards: The human disease database

(2) MalaCards diseases for CNTROB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
squamous cell papilloma
  • epidermoid papilloma
salivary gland disease
  • non-neoplastic salivary gland disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CNTROB

Genetic Association Database (GAD)
CNTROB
Human Genome Epidemiology (HuGE) Navigator
CNTROB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNTROB
genes like me logo Genes that share disorders with CNTROB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNTROB Gene

Publications for CNTROB Gene

  1. Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. (PMID: 16275750) Zou C. … Gao Q. (J. Cell Biol. 2005) 2 3 4 22 64
  2. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PMID: 11984006) Tchernev V.T. … Kingsmore S.F. (Mol. Med. 2002) 2 3 4 64
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  4. Inhibition of centriole duplication by centrobin depletion leads to p38-p53 mediated cell-cycle arrest. (PMID: 20085806) Song L. … Li J. (Cell. Signal. 2010) 3 22 64
  5. Centrobin regulates the assembly of functional mitotic spindles. (PMID: 20190801) Jeffery J.M. … Khanna K.K. (Oncogene 2010) 3 22 64

Products for CNTROB Gene

Sources for CNTROB Gene

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