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Aliases for CNTROB Gene

Aliases for CNTROB Gene

  • Centrobin, Centrosomal BRCA2 Interacting Protein 2 3
  • Centrosomal BRCA2-Interacting Protein 3 4
  • LYST-Interacting Protein 8 3 4
  • Centrobin 2 3
  • LIP8 3 4
  • LYST-Interacting Protein LIP8 3
  • PP1221 3

External Ids for CNTROB Gene

Summaries for CNTROB Gene

Entrez Gene Summary for CNTROB Gene

  • This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CNTROB Gene

CNTROB (Centrobin, Centrosomal BRCA2 Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding.

UniProtKB/Swiss-Prot for CNTROB Gene

  • Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.

Gene Wiki entry for CNTROB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTROB Gene

Genomics for CNTROB Gene

Genomic Location for CNTROB Gene

Start:
7,932,101 bp from pter
End:
7,949,919 bp from pter
Size:
17,819 bases
Orientation:
Plus strand

Genomic View for CNTROB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNTROB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTROB Gene

Regulatory Elements for CNTROB Gene

Proteins for CNTROB Gene

  • Protein details for CNTROB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N137-CNTRB_HUMAN
    Recommended name:
    Centrobin
    Protein Accession:
    Q8N137
    Secondary Accessions:
    • A6NHQ1
    • Q331K3
    • Q69YV7
    • Q8NCB8
    • Q8WXV3
    • Q96CQ7
    • Q9C060

    Protein attributes for CNTROB Gene

    Size:
    903 amino acids
    Molecular mass:
    101253 Da
    Quaternary structure:
    • Interacts with LYST.
    SequenceCaution:
    • Sequence=AAG49447.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAG49447.1; Type=Frameshift; Positions=609; Evidence={ECO:0000305}; Sequence=BAC11241.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CNTROB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNTROB Gene

Proteomics data for CNTROB Gene at MOPED

Post-translational modifications for CNTROB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys610, Lys761, and Lys832

No data available for DME Specific Peptides for CNTROB Gene

Domains for CNTROB Gene

Protein Domains for CNTROB Gene

ProtoNet:
genes like me logo Genes that share domains with CNTROB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CNTROB Gene

Function for CNTROB Gene

Molecular function for CNTROB Gene

UniProtKB/Swiss-Prot Function: Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.

Gene Ontology (GO) - Molecular Function for CNTROB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16275750
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with CNTROB: view

Phenotypes for CNTROB Gene

GenomeRNAi human phenotypes for CNTROB:
genes like me logo Genes that share phenotypes with CNTROB: view

miRNA for CNTROB Gene

miRTarBase miRNAs that target CNTROB

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNTROB Gene

Localization for CNTROB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTROB Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNTROB Gene COMPARTMENTS Subcellular localization image for CNTROB gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CNTROB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IMP 21576394
GO:0005814 centriole IDA 16275750
genes like me logo Genes that share ontologies with CNTROB: view

Pathways for CNTROB Gene

SuperPathways for CNTROB Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTROB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007099 centriole replication IMP 16275750
GO:0051299 centrosome separation IMP 16275750
GO:1902410 mitotic cytokinetic process IMP 16275750
genes like me logo Genes that share ontologies with CNTROB: view

No data available for Pathways by source for CNTROB Gene

Transcripts for CNTROB Gene

Unigene Clusters for CNTROB Gene

Centrobin, centrosomal BRCA2 interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNTROB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: -
SP2: -
SP3: -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CNTROB Gene

GeneLoc Exon Structure for
CNTROB
ECgene alternative splicing isoforms for
CNTROB

Expression for CNTROB Gene

mRNA expression in normal human tissues for CNTROB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNTROB Gene

SOURCE GeneReport for Unigene cluster for CNTROB Gene Hs.348012

mRNA Expression by UniProt/SwissProt for CNTROB Gene

Q8N137-CNTRB_HUMAN
Tissue specificity: Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expressions with CNTROB: view

Orthologs for CNTROB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNTROB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTROB 36
  • 99.63 (n)
  • 99.56 (a)
CNTROB 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNTROB 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNTROB 36
  • 84.24 (n)
  • 84.46 (a)
CNTROB 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cntrob 36
  • 84.63 (n)
  • 85.76 (a)
Cntrob 16
Cntrob 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNTROB 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNTROB 37
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cntrob 36
  • 84.69 (n)
  • 86.15 (a)
lizard
(Anolis carolinensis)
Reptilia CNTROB 37
  • 44 (a)
OneToOne
Species with no ortholog for CNTROB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CNTROB Gene

ENSEMBL:
Gene Tree for CNTROB (if available)
TreeFam:
Gene Tree for CNTROB (if available)

Paralogs for CNTROB Gene

No data available for Paralogs for CNTROB Gene

Variants for CNTROB Gene

Sequence variations from dbSNP and Humsavar for CNTROB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4239116 -- 7,945,190(+) CGTTG(A/G)TACTT intron-variant
rs4300713 -- 7,941,956(+) gagac(C/T)gagtc intron-variant
rs4462664 -- 7,945,399(+) ATATA(C/T)TTATC intron-variant
rs4462665 -- 7,945,769(+) GAGCC(C/G)GAGAA reference, synonymous-codon, nc-transcript-variant
rs4473260 -- 7,945,476(+) CTTCC(C/T)GAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNTROB Gene

Variant ID Type Subtype PubMed ID
nsv457660 CNV Loss 19166990
esv2670156 CNV Deletion 23128226

Relevant External Links for CNTROB Gene

HapMap Linkage Disequilibrium report
CNTROB
Human Gene Mutation Database (HGMD)
CNTROB

Disorders for CNTROB Gene

Relevant External Links for CNTROB

Genetic Association Database (GAD)
CNTROB
Human Genome Epidemiology (HuGE) Navigator
CNTROB
genes like me logo Genes that share disorders with CNTROB: view

No data available for UniProtKB/Swiss-Prot for CNTROB Gene

Publications for CNTROB Gene

  1. Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. (PMID: 16275750) Zou C. … Gao Q. (J. Cell Biol. 2005) 2 3 4 23
  2. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PMID: 11984006) Tchernev V.T. … Kingsmore S.F. (Mol. Med. 2002) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization. (PMID: 17535851) Jeong Y. … Rhee K. (J. Cell. Sci. 2007) 3 23
  5. Inhibition of centriole duplication by centrobin depletion leads to p38-p53 mediated cell-cycle arrest. (PMID: 20085806) Song L. … Li J. (Cell. Signal. 2010) 3 23

Products for CNTROB Gene

  • antibodies-online peptides for CNTROB
  • antibodies-online antibodies for CNTROB
  • antibodies-online kits for CNTROB

Sources for CNTROB Gene

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