CNTROB Gene
protein-coding GIFtS: 47
GCID: GC17P007835
|
|
centrobin, centrosomal BRCA2 interacting protein
| |
Aliases
for CNTROB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centrobin, Centrosomal BRCA2 Interacting Protein1 2 | | PP12211 | | LIP81 2 3 | | Centrobin1 | | Centrosomal BRCA2-Interacting Protein2 3 | | LYST-Interacting Protein LIP82 | | LYST-Interacting Protein 82 3 | | |
Export aliases for CNTROB gene to outside databasesPrevious GC identifer: GC17P007777 |
Summaries
for CNTROB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CNTROB:
This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication andcytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.(provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: CNTRB_HUMAN, Q8N137Function: Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis
Gene Wiki entry for CNTROB
|
Genomic Views
for CNTROB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CNTROB gene promoter:
Elk-1 Pbx1a Sp1 NCX/Ncx NF-kappaB GATA-2 SREBP-1a ZID NF-kappaB1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNTROB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTROB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1CNTROB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P007835: view genomic region
(about GC identifiers)
Start:
|
7,835,419 bp from pter |
End:
|
7,853,236 bp from pter |
Size:
|
17,818 bases |
Orientation:
|
plus strand |
|
Proteins
for CNTROB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CNTRB_HUMAN, Q8N137 (See
protein sequence)Recommended Name: Centrobin Size: 903 amino acids; 101253 Da
Subunit: Interacts with LYST
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Centriole-associated, asymmetricallylocalizes to the daughter centriole
Developmental stage: Preferentially incorporated into the newly assembled daughter centriole during centriole assemblyat the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle ofcentriole duplication, its amount on the original daughter centriole eventually decreases
Sequence caution: Sequence=AAG49447.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=AAG49447.1;Type=Frameshift; Positions=609; Sequence=BAC11241.1; Type=Erroneous initiation;
Secondary accessions: A6NHQ1 Q331K3 Q69YV7 Q8NCB8 Q8WXV3 Q96CQ7 Q9C060Alternative splicing: 5 isoforms: Q8N137-1 Q8N137-2 Q8N137-3 Q8N137-4 Q8N137-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CNTROB: NX_Q8N137
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N137
CNTROB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001032221.1 NP_444279.2
ENSEMBL proteins: ENSP00000459246 ENSP00000369614 ENSP00000456335 ENSP00000460583 ENSP00000461000 ENSP00000458696 ENSP00000454840 ENSP00000458688 ENSP00000458787 ENSP00000458251 ENSP00000369605
Human Recombinant Protein Products for CNTROB:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CNTROB for ontologies About GeneDecksing
CNTROB Antibody Products:
Assay Products for CNTROB: |
Protein
Domains /
Families
for CNTROB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8N137 |
Function
for CNTROB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CNTRB_HUMAN, Q8N137Function: Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CNTROB for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for CNTROB:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTROB (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CNTROB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTROB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTROB |
|
Pathways & Interactions
for CNTROB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNTROB
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for CNTROB (Q8N1372, 3 ENSP000003696144) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CNTROB for ontologies About GeneDecksing
|
Drugs & Compounds
for CNTROB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CNTROB
Search CenterWatch for drugs/clinical trials and news about CNTROB / CNTRB
|
Transcripts
for CNTROB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CNTROB gene (2 alternative transcripts): NM_001037144.5 NM_053051.3 Unigene Cluster for CNTROB: Centrobin, centrosomal BRCA2 interacting protein Hs.348012 [show with all ESTs]Unigene Representative Sequence: NM_00103714416 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000576538 ENST00000380262(uc002gjp.3) ENST00000563694(uc002gjq.3)
ENST00000570782 ENST00000570784 ENST00000575408 ENST00000565740(uc002gjr.3)
ENST00000571540 ENST00000571632 ENST00000576587 ENST00000576922(uc010vum.1)
ENST00000574430 ENST00000576723 ENST00000573862 ENST00000576536 ENST00000380255
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTROB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTROB (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Synthesis Service for CNTROB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTROB |
Additional cDNA sequence: AF141344.1 AF331638.2 AK293076.1 AK303093.1 AL833907.1 AY160226.1 AY160227.1 BC014055.2 BC021134.1 17 DOTS entries: DT.95180090 DT.86854406 DT.100028963 DT.95174923 DT.95174926 DT.100777902 DT.120903669 DT.95118122 DT.95174925 DT.95186263 DT.100777900 DT.100777901 DT.92040942 DT.92433188 DT.95174922 DT.95301845 DT.40248058 24/188 AceView cDNA sequences (see all 188): BM910758 AI917429 BC014055 CR601905 BU169117 AI090055 BX097118 BG390883 AI376821 BQ706760 AL137669 BC021134 BG388890 BQ773018 AL558225 BQ898258 CF995713 BU726686 AI768983 BM703719 BM469150 BU844407 AL535211 BM127046
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CNTROB (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 |
|---|
|
| SP1: | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CNTROB
|
Expression
for CNTROB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNTROB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAGCCGGG
About this image
See CNTROB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNTROB
SOURCE GeneReport for Unigene cluster: Hs.348012
UniProtKB/Swiss-Prot: CNTRB_HUMAN, Q8N137Tissue specificity: Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus,prostate, small intestine, colon and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for CNTROB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNTROB
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTROB |
Orthologs
for CNTROB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CNTROB gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for CNTROB (if available)
TreeFam Gene Tree for CNTROB (if available) |
Paralogs
for CNTROB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CNTROB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CNTROB (7835419 - 7853236 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CNTROB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNTROB |
|
Disorders
/ Diseases
for CNTROB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CNTROB for disorders About GeneDecksing
OMIM gene information: 611425
OMIM disorders: --
3  diseases for CNTROB: About MalaCardsbreast cancer ataxia prostatitis
Human Genome Epidemiology (HuGE) Navigator: CNTROB (1 document)
Export disorders for CNTROB gene to outside databases
|
Publications
for CNTROB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CNTROB gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with CNTROB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. (PubMed id 16275750)1, 2, 3, 9 Zou C.... Gao Q. (2005)
- The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PubMed id 11984006)1, 2, 3 Tchernev V.T....Kingsmore S.F. (2002)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Inhibition of centriole duplication by centrobin depl etion leads to p38-p53 mediated cell-cycle arrest. (PubMed id 20085806)1, 9 Song L....Li J. (2010)
- Centrobin regulates the assembly of functional mitoti c spindles. (PubMed id 20190801)1, 9 Jeffery J.M....Khanna K.K. (2010)
- Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization. (PubMed id 17535851)1, 9 Jeong Y....Rhee K. (2007)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Centrobin-tubulin interaction is required for centrio le elongation and stability. (PubMed id 21576394)1 Gudi R....Gao Q. (2011)
|
External Searches for CNTROB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CNTROB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CNTROB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CNTROB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CNTROB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CNTROB gene:
Search GeneIP for patents involving CNTROB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CNTROB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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