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Aliases for CNTRL Gene

Aliases for CNTRL Gene

  • Centriolin 2 3
  • CEP110 3 4 6
  • CEP1 3 4 6
  • Centrosomal Protein Of 110 KDa 3 4
  • Centrosomal Protein 110kDa 2 3
  • Centrosomal Protein 1 2 4
  • FAN 3 6
  • BA165P4.1 (Ortholog Of Mouse Ma2a8) 3
  • BA165P4.2 (Centrosomal Protein 1) 3
  • Centriole Associated Protein 3
  • 110 KDa Centrosomal Protein 3
  • BA165P4.1 3

External Ids for CNTRL Gene

Previous Symbols for CNTRL Gene

  • CEP1
  • CEP110

Summaries for CNTRL Gene

Entrez Gene Summary for CNTRL Gene

  • This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNTRL Gene

CNTRL (Centriolin) is a Protein Coding gene. Diseases associated with CNTRL include 8p11 myeloproliferative syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR1 mutants. An important paralog of this gene is LRRC49.

UniProtKB/Swiss-Prot for CNTRL Gene

  • Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.

Gene Wiki entry for CNTRL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTRL Gene

Genomics for CNTRL Gene

Genomic Location for CNTRL Gene

Start:
121,074,863 bp from pter
End:
121,177,610 bp from pter
Size:
102,748 bases
Orientation:
Plus strand

Genomic View for CNTRL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNTRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTRL Gene

No data available for Regulatory Elements for CNTRL Gene

Proteins for CNTRL Gene

  • Protein details for CNTRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7A1-CNTRL_HUMAN
    Recommended name:
    Centriolin
    Protein Accession:
    Q7Z7A1
    Secondary Accessions:
    • A2A2Y1
    • B2RP67
    • Q3MN79
    • Q5FWF8
    • Q5JVD0
    • Q6MZR3
    • Q6PKC1
    • Q8TEP3
    • Q9Y489

    Protein attributes for CNTRL Gene

    Size:
    2325 amino acids
    Molecular mass:
    268886 Da
    Quaternary structure:
    • Interacts with HOOK2. Interacts with EXOC6 and SNAPIN. Associates with the exocyst complex.
    SequenceCaution:
    • Sequence=AAH02932.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH02932.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH89415.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for CNTRL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNTRL Gene

Proteomics data for CNTRL Gene at MOPED

Post-translational modifications for CNTRL Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys101 and Lys1170

Other Protein References for CNTRL Gene

No data available for DME Specific Peptides for CNTRL Gene

Domains for CNTRL Gene

Protein Domains for CNTRL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNTRL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7A1

UniProtKB/Swiss-Prot:

CNTRL_HUMAN
Domain:
  • Contains 1 LRRCT domain.:
    • Q7Z7A1
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.:
    • Q7Z7A1
genes like me logo Genes that share domains with CNTRL: view

No data available for Gene Families for CNTRL Gene

Function for CNTRL Gene

Molecular function for CNTRL Gene

UniProtKB/Swiss-Prot Function: Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.

Gene Ontology (GO) - Molecular Function for CNTRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005515 protein binding IPI 17140400
genes like me logo Genes that share ontologies with CNTRL: view
genes like me logo Genes that share phenotypes with CNTRL: view

miRNA for CNTRL Gene

miRTarBase miRNAs that target CNTRL

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNTRL Gene

Localization for CNTRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTRL Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=During cytokinesis, localizes to a ring-like structure at the central midbody.

Gene Ontology (GO) - Cellular Components for CNTRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CNTRL: view

No data available for Subcellular locations from COMPARTMENTS for CNTRL Gene

Pathways for CNTRL Gene

genes like me logo Genes that share pathways with CNTRL: view

Gene Ontology (GO) - Biological Process for CNTRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CNTRL: view

Transcripts for CNTRL Gene

Unigene Clusters for CNTRL Gene

Centriolin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNTRL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^
SP1: - - - - -
SP2:
SP3: - - -
SP4: - - -
SP5: - -
SP6:
SP7:

ExUns: 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CNTRL Gene

GeneLoc Exon Structure for
CNTRL
ECgene alternative splicing isoforms for
CNTRL

Expression for CNTRL Gene

mRNA expression in normal human tissues for CNTRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTRL Gene

This gene is overexpressed in Testis (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNTRL Gene

SOURCE GeneReport for Unigene cluster for CNTRL Gene Hs.653263

mRNA Expression by UniProt/SwissProt for CNTRL Gene

Q7Z7A1-CNTRL_HUMAN
Tissue specificity: Highly expressed in testis and trachea.
genes like me logo Genes that share expressions with CNTRL: view

Orthologs for CNTRL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNTRL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP110 35
  • 99.66 (n)
  • 99.44 (a)
CEP110 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNTRL 35
  • 86.45 (n)
  • 85.04 (a)
CNTRL 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNTRL 35
  • 86.83 (n)
  • 85.36 (a)
CNTRL 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep110 35
  • 82.88 (n)
  • 81.31 (a)
Cep110 16
Cep110 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNTRL 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNTRL 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cntrl 35
  • 82.35 (n)
  • 80.65 (a)
chicken
(Gallus gallus)
Aves CNTRL 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.6532 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cntrl 35
  • 61.19 (n)
  • 56.56 (a)
zebrafish
(Danio rerio)
Actinopterygii CU856237.1 36
  • 32 (a)
ManyToMany
LOC100334259 35
  • 52.47 (n)
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SDS22 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for CNTRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNTRL Gene

ENSEMBL:
Gene Tree for CNTRL (if available)
TreeFam:
Gene Tree for CNTRL (if available)

Paralogs for CNTRL Gene

Paralogs for CNTRL Gene

Selected SIMAP similar genes for CNTRL Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CNTRL: view

Variants for CNTRL Gene

Sequence variations from dbSNP and Humsavar for CNTRL Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs734177 -- 121,169,136(-) GTTCA(A/G)TTGGA intron-variant
rs746182 -- 121,168,687(+) TTCTT(C/T)TGTCC intron-variant
rs875593 -- 121,124,809(+) tagtg(G/T)tatgt intron-variant
rs1016468 -- 121,109,878(+) TATTT(C/T)GTATT intron-variant
rs1140742 -- 121,161,861(+) AACTA(A/C)AGAAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CNTRL Gene

Variant ID Type Subtype PubMed ID
esv2656882 CNV Deletion 23128226
esv23303 CNV Loss 19812545
esv2738999 CNV Deletion 23290073
esv2671048 CNV Deletion 23128226
esv1148139 CNV Deletion 17803354
nsv825071 CNV Loss 20364138
esv2675601 CNV Deletion 23128226

Relevant External Links for CNTRL Gene

HapMap Linkage Disequilibrium report
CNTRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTRL Gene

Disorders for CNTRL Gene

UniProtKB/Swiss-Prot

CNTRL_HUMAN
  • Note=A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
genes like me logo Genes that share disorders with CNTRL: view

Publications for CNTRL Gene

  1. Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. (PMID: 16213214) Gromley A. … Doxsey S.J. (Cell 2005) 3 4 23
  2. A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. (PMID: 12732615) Gromley A. … Doxsey S.J. (J. Cell Biol. 2003) 3 4 23
  3. FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33). (PMID: 10688839) Guasch G. … Pebusque M.-J. (Blood 2000) 2 3 4
  4. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. (PMID: 11956314) Ou Y.Y. … Rattner J.B. (J. Cell Sci. 2002) 3 4
  5. Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. (PMID: 17140400) Szebenyi G. … Kraemer H. (Traffic 2007) 3 4

Products for CNTRL Gene

Sources for CNTRL Gene

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