Aliases for CNTRL Gene
External Ids for CNTRL Gene
Previous HGNC Symbols for CNTRL Gene
Previous GeneCards Identifiers for CNTRL Gene
This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for CNTRL Gene
CNTRL (Centriolin) is a Protein Coding gene. Diseases associated with CNTRL include 8P11 Myeloproliferative Syndrome and Microcephalic Osteodysplastic Primordial Dwarfism, Type Ii. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and FGFR1 mutant receptor activation. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is LRRC9.
UniProtKB/Swiss-Prot for CNTRL Gene
Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.