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Aliases for CNTNAP5 Gene

Aliases for CNTNAP5 Gene

  • Contactin Associated Protein-Like 5 2 3 5
  • Cell Recognition Molecule Caspr5 3 4
  • Caspr5 3 4

External Ids for CNTNAP5 Gene

Previous GeneCards Identifiers for CNTNAP5 Gene

  • GC02P124879
  • GC02P124499
  • GC02P117103

Summaries for CNTNAP5 Gene

Entrez Gene Summary for CNTNAP5 Gene

  • This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNTNAP5 Gene

CNTNAP5 (Contactin Associated Protein-Like 5) is a Protein Coding gene. Diseases associated with CNTNAP5 include mowat-wilson syndrome. An important paralog of this gene is CNTNAP1.

UniProtKB/Swiss-Prot for CNTNAP5 Gene

  • May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTNAP5 Gene

Genomics for CNTNAP5 Gene

Regulatory Elements for CNTNAP5 Gene

Genomic Location for CNTNAP5 Gene

Chromosome:
2
Start:
124,025,287 bp from pter
End:
124,921,201 bp from pter
Size:
895,915 bases
Orientation:
Plus strand

Genomic View for CNTNAP5 Gene

Genes around CNTNAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTNAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTNAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTNAP5 Gene

Proteins for CNTNAP5 Gene

  • Protein details for CNTNAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYK1-CNTP5_HUMAN
    Recommended name:
    Contactin-associated protein-like 5
    Protein Accession:
    Q8WYK1
    Secondary Accessions:
    • Q4ZFW2
    • Q4ZG21
    • Q53R09
    • Q53RX1
    • Q53SG3
    • Q584P3
    • Q96MS7

    Protein attributes for CNTNAP5 Gene

    Size:
    1306 amino acids
    Molecular mass:
    145623 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CNTNAP5 Gene

Proteomics data for CNTNAP5 Gene at MOPED

Post-translational modifications for CNTNAP5 Gene

  • Glycosylation at Asn 282, Asn 355, Asn 496, Asn 571, and Asn 622
  • Modification sites at PhosphoSitePlus

Other Protein References for CNTNAP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNTNAP5 Gene

Domains & Families for CNTNAP5 Gene

Suggested Antigen Peptide Sequences for CNTNAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYK1

UniProtKB/Swiss-Prot:

CNTP5_HUMAN :
  • Contains 2 EGF-like domains.
  • Belongs to the neurexin family.
Domain:
  • Contains 2 EGF-like domains.
  • Contains 1 F5/8 type C domain.
  • Contains 1 fibrinogen C-terminal domain.
  • Contains 4 laminin G-like domains.
Family:
  • Belongs to the neurexin family.
genes like me logo Genes that share domains with CNTNAP5: view

No data available for Gene Families for CNTNAP5 Gene

Function for CNTNAP5 Gene

Molecular function for CNTNAP5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.
genes like me logo Genes that share phenotypes with CNTNAP5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNTNAP5 Gene

Localization for CNTNAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTNAP5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNTNAP5 Gene COMPARTMENTS Subcellular localization image for CNTNAP5 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
cytosol 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CNTNAP5 Gene

Pathways & Interactions for CNTNAP5 Gene

SuperPathways for CNTNAP5 Gene

No Data Available

Interacting Proteins for CNTNAP5 Gene

Gene Ontology (GO) - Biological Process for CNTNAP5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CNTNAP5 Gene

Drugs & Compounds for CNTNAP5 Gene

No Compound Related Data Available

Transcripts for CNTNAP5 Gene

mRNA/cDNA for CNTNAP5 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNTNAP5 Gene

Contactin associated protein-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNTNAP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1:
SP2:

Relevant External Links for CNTNAP5 Gene

GeneLoc Exon Structure for
CNTNAP5
ECgene alternative splicing isoforms for
CNTNAP5

Expression for CNTNAP5 Gene

mRNA expression in normal human tissues for CNTNAP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTNAP5 Gene

This gene is overexpressed in Brain - Cortex (x6.6), Brain - Frontal Cortex (BA9) (x6.3), Brain - Anterior cingulate cortex (BA24) (x6.1), Brain - Hypothalamus (x5.6), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for CNTNAP5 Gene

This gene is overexpressed in Fetal Brain (31.7) and Frontal cortex (28.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNTNAP5 Gene



SOURCE GeneReport for Unigene cluster for CNTNAP5 Gene Hs.660653

genes like me logo Genes that share expression patterns with CNTNAP5: view

Protein tissue co-expression partners for CNTNAP5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CNTNAP5 Gene

Orthologs for CNTNAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNTNAP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNTNAP5 35
  • 88.43 (n)
  • 90.45 (a)
CNTNAP5 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNTNAP5 35
  • 90.55 (n)
  • 93.26 (a)
CNTNAP5 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cntnap5a 35
  • 84.25 (n)
  • 85.12 (a)
Cntnap5a 16
Cntnap5a 36
  • 85 (a)
OneToMany
Cntnap5b 36
  • 82 (a)
OneToMany
Cntnap5c 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CNTNAP5 35
  • 99.49 (n)
  • 99.43 (a)
CNTNAP5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cntnap5a 35
  • 82.81 (n)
  • 81.76 (a)
oppossum
(Monodelphis domestica)
Mammalia CASPR5 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNTNAP5 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNTNAP5 35
  • 75.65 (n)
  • 79.05 (a)
CNTNAP5 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNTNAP5 36
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC569185 35
  • 61.58 (n)
  • 57.36 (a)
CNTNAP5 36
  • 51 (a)
OneToMany
cntnap5a 36
  • 56 (a)
OneToMany
cntnap5b 36
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nlr-1 35
  • 40.77 (n)
  • 30.19 (a)
Species with no ortholog for CNTNAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CNTNAP5 Gene

ENSEMBL:
Gene Tree for CNTNAP5 (if available)
TreeFam:
Gene Tree for CNTNAP5 (if available)

Paralogs for CNTNAP5 Gene

Paralogs for CNTNAP5 Gene

(7) SIMAP similar genes for CNTNAP5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNTNAP5: view

Variants for CNTNAP5 Gene

Sequence variations from dbSNP and Humsavar for CNTNAP5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17727261 - 124,524,333(+) GCACT(C/T)GGTTA reference, missense
rs34165507 - 124,903,032(+) CTTGA(A/C/T)GGAAT reference, missense
rs314700 -- 124,835,395(-) TTTAA(A/G)AGGAT intron-variant
rs314701 -- 124,832,841(-) ttaac(A/C)tgcag intron-variant
rs314702 -- 124,823,711(+) AACAC(C/T)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNTNAP5 Gene

Variant ID Type Subtype PubMed ID
esv2720689 CNV Deletion 23290073
esv2514577 CNV Deletion 19546169
esv2413609 CNV Deletion 18987734
esv28944 CNV Loss 19812545
esv2667022 CNV Deletion 23128226
nsv874989 CNV Loss 21882294
esv271612 CNV Insertion 20981092
esv21989 CNV Loss 19812545
nsv874990 CNV Loss 21882294
nsv513642 OTHER Inversion 21212237
nsv523624 CNV Loss 19592680
nsv523244 CNV Gain 19592680
dgv62n68 CNV Gain 17160897
nsv2902 CNV Insertion 18451855
nsv518449 CNV Loss 19592680
nsv214662 CNV Insertion 16902084
esv2660051 CNV Deletion 23128226
nsv834357 CNV Gain 17160897
esv1132457 CNV Insertion 17803354
esv1651761 CNV Deletion 17803354
nsv520468 CNV Loss 19592680
esv25452 CNV Loss 19812545
nsv819837 CNV Gain 19587683
nsv528674 CNV Loss 19592680
nsv834359 CNV Gain 17160897
esv2401454 CNV Deletion 18987734
esv2720690 CNV Deletion 23290073
esv2152580 CNV Deletion 18987734
esv2720691 CNV Deletion 23290073
esv2720692 CNV Deletion 23290073
esv1751956 CNV Deletion 17803354
nsv214838 CNV Loss 16902084
esv2675025 CNV Deletion 23128226
esv259825 OTHER Complex 20981092
esv272158 CNV Insertion 20981092
esv2720693 CNV Deletion 23290073
nsv834360 CNV Gain 17160897
esv271000 CNV Insertion 20981092
esv1473492 CNV Insertion 17803354
esv1460286 CNV Insertion 17803354
nsv834361 CNV Gain 17160897
esv27405 CNV Loss 19812545
esv2720694 CNV Deletion 23290073
esv2669295 CNV Deletion 23128226
nsv441780 CNV CNV 18776908
esv2421661 CNV Deletion 20811451
nsv514089 CNV Loss 21397061

Variation tolerance for CNTNAP5 Gene

Residual Variation Intolerance Score: 8.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNTNAP5 Gene

HapMap Linkage Disequilibrium report
CNTNAP5
Human Gene Mutation Database (HGMD)
CNTNAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTNAP5 Gene

Disorders for CNTNAP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CNTNAP5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mowat-wilson syndrome
  • hirschsprung disease mental retardation syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CNTNAP5

Genetic Association Database (GAD)
CNTNAP5
Human Genome Epidemiology (HuGE) Navigator
CNTNAP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNTNAP5
genes like me logo Genes that share disorders with CNTNAP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNTNAP5 Gene

Publications for CNTNAP5 Gene

  1. Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. (PMID: 19721433) McClay J.L. … van den Oord E.J. (Mol. Psychiatry 2011) 3 48 67
  2. New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene. (PMID: 16845472) Traut W. … Winking H. (Mamm. Genome 2006) 3 23
  3. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  4. Genome-wide association study of multiplex schizophrenia pedigrees. (PMID: 22885689) Levinson D.F. … Holmans P.A. (Am J Psychiatry 2012) 3
  5. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3

Products for CNTNAP5 Gene

Sources for CNTNAP5 Gene

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