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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNTNAP4 Gene

protein-coding   GIFtS: 53
GCID: GC16P076311

contactin associated protein-like 4

 Explore 5 diseases affiliated with
CNTNAP4 via our new
 Human Malady Compendium 
Biological research products
for CNTNAP4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Contactin Associated Protein-Like 41 2
CASPR41 2 3
KIAA17631 3
Cell Recognition Molecule Caspr42 3
Cell Recognition Protein CASPR42
Contactin-Associated Protein-Like 42

External Ids:    HGNC: 187471   Entrez Gene: 854452   Ensembl: ENSG000001529107   OMIM: 6105185   UniProtKB: Q9C0A03   

Export aliases for CNTNAP4 gene to outside databases

Previous GC identifers: GC16P076123 GC16P074868 GC16P074901 GC16P062072


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNTNAP4:
This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell
adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats
and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like
domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

Gene Wiki entry for CNTNAP4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNTNAP4 gene promoter:
         STAT5B   POU3F2 (N-Oct-5a)   POU3F2   HNF-1A   FOXL1   AREB6   HNF-1   STAT3   Cart-1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNTNAP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNTNAP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTNAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q23.1

CNTNAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNTNAP4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P076311:  view genomic region     (about GC identifiers)

Start:
76,311,176 bp from pter      End:
76,593,135 bp from pter
Size:
281,960 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNTP4_HUMAN, Q9C0A0 (See protein sequence)
Recommended Name: Contactin-associated protein-like 4 precursor  
Size: 1308 amino acids; 145274 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=BAB21854.2; Type=Erroneous initiation;
Secondary accessions: E9PFZ6 Q86YZ7
Alternative splicing: 2 isoforms:  Q9C0A0-1   Q9C0A0-2   

Explore the universe of human proteins at neXtProt for CNTNAP4: NX_Q9C0A0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C0A0

  • CNTNAP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_207837.2  NP_620481.2  

    ENSEMBL proteins: 
     ENSP00000418741   ENSP00000417628   ENSP00000306893   ENSP00000439733  

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    Uscn Proteins for CNTNAP4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0030425dendrite ----


    CNTNAP4 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CNTNAP4 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR008979 Galactose-bd-like

    Graphical View of Domain Structure for InterPro Entry Q9C0A0

    ProtoNet protein and cluster: Q9C0A0

    2 Blocks protein families:
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB001791 Laminin G


    UniProtKB/Swiss-Prot: CNTP4_HUMAN, Q9C0A0
    Similarity: Belongs to the neurexin family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 F5/8 type C domain
    Similarity: Contains 1 fibrinogen C-terminal domain
    Similarity: Contains 4 laminin G-like domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005515protein binding ----


    CNTNAP4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CNTNAP4:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNTNAP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for CNTNAP4 (Q9C0A02, 3 ENSP000004176284) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASKO149362, 3, ENSP000003674084MINT-58197 I2D: score=4 STRING: ENSP00000367408
    RANBP10Q6VN203, ENSP000003165894I2D: score=2 STRING: ENSP00000316589
    MAST3O603073, ENSP000002628114I2D: score=1 STRING: ENSP00000262811
    APBA1Q024103, ENSP000002653814I2D: score=2 STRING: ENSP00000265381
    FBXO21O949523, ENSP000003281874I2D: score=2 STRING: ENSP00000328187
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction IEA--


    CNTNAP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNTNAP4
    Search CenterWatch for drugs/clinical trials and news about CNTNAP4 / CNTP4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNTNAP4 gene (2 alternative transcripts): 
    NM_033401.3  NM_138994.3  

    Unigene Cluster for CNTNAP4:

    Contactin associated protein-like 4
    Hs.461389  [show with all ESTs]
    Unigene Representative Sequence: NM_033401
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469589(uc002feu.1 uc002fev.1 uc010chb.1 uc002fex.1)
    ENST00000469667 ENST00000471618(uc002few.2) ENST00000463177 ENST00000478060
    ENST00000476707 ENST00000569946 ENST00000307431 ENST00000377504

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    Inhib. RNA
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    Additional cDNA sequence: 

    AB051550.2 AB100092.1 AB100093.1 AB100094.1 BC017266.2 

    6 DOTS entries:

    DT.40309235  DT.100748634  DT.95147180  DT.95197072  DT.100748633  DT.91970879 

    24/33 AceView cDNA sequences (see all 33):

    NM_138994 CR616666 AK057327 AI803984 NM_033401 BX508065 AB051550 BX113873 
    AI336983 AF463518 AW235923 BM544789 AB100092 AV728644 AB100093 AI190672 
    AI352097 AI954637 Z44514 AK054786 AB100094 Z40413 BX420987 BI752001 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CNTNAP4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:              -     -                                                                                   -                                                   
    SP2:              -     -                                   -                                               -                                                   
    SP3:                                                                                                        -                                                   
    SP4:                    -                                                                                                                                       

    ExUns: 24 ^ 25a · 25b · 25c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        


    ECgene alternative splicing isoforms for CNTNAP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNTNAP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATACATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CNTNAP4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)
    Beating cell clusters (Spontaneous differen...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CNTNAP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNTNAP4

    SOURCE GeneReport for Unigene cluster: Hs.461389
        SABiosciences Custom PCR Arrays for CNTNAP4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTNAP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CNTNAP4 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC4305321 contactin-associated protein-like 4-like 74.41(n)
    70.27(a)
      430532  XM_428089.3  XP_428089.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    69(a)
    1 ↔ 1
    2(38455505-38592818)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.126442 Transcribed sequence with weak similarity to protein more 76.86(n)    BX712039.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cntnap41 contactin associated protein-like 4 59.92(n)
    55.43(a)
      564195  XM_003199273.1  XP_003199321.1 


    ENSEMBL Gene Tree for CNTNAP4 (if available)
    TreeFam Gene Tree for CNTNAP4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNTNAP4 gene
    CNTNAP12  NRXN32  CNTNAP52  CNTNAP3B2  NRXN22  LOC6437922  CNTNAP32  CNTNAP22  
    NRXN12  
    9 SIMAP similar genes for CNTNAP4 using alignment to 3 protein entries:     CNTP4_HUMAN (see all proteins):
    CASPR4    CNTNAP3    CNTNAP3B    CNTNAP5    CNTNAP2    CNTNAP1
    EGFLAM    DKFZp686I15204    WUGSC

    CNTNAP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6094 NCBI SNPs in CNTNAP4 are shown (see all 6094    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999143171,2
    C--62103316(+) AACATG/TTTTTT 1 -- int10--------
    rs736193001,2
    C,F,--62103561(+) ATCACC/GTATGC 1 -- int14Minor allele frequency- G:0.11WA CSA 123
    rs727949451,2
    C,F,--62103694(+) ACTACA/CTAGGG 1 -- int11Minor allele frequency- C:0.06NA 120
    rs749952191,2
    F,--62103855(+) TAGTGG/ATTTCC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs783297071,2
    F,--62104499(+) CAGAGG/ACTGTT 1 -- int11Minor allele frequency- A:0.09WA 118
    rs80552091,2
    H--62105126(+) ttcttC/Tcccgt 1 -- int1 trp34Minor allele frequency- T:0.00NS EA 400
    rs102211531,2
    C,H,--62105527(+) CTAACA/GAGTAA 1 -- int14Minor allele frequency- G:0.01NS EA WA 404
    rs740249851,2
    C,--62105741(+) GGGAAC/GGAGAC 1 -- int12Minor allele frequency- G:0.06WA 120
    rs558830211,2
    C,--62106189(+) GTGTCC/TCTAGA 1 -- int12Minor allele frequency- T:0.05WA 120
    rs736193021,2
    C,F,--62106997(+) CAGACG/ATCCAT 1 -- int14Minor allele frequency- A:0.16WA CSA 123

    HapMap Linkage Disequilibrium report for CNTNAP4 (76311176 - 76561176 bp, first 250kb of CNTNAP4)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for CNTNAP4
         11 CNVs: 67040 35409 5438 39188 88220 58776 35410 61539 43580 88221 72618
    Human Gene Mutation Database (HGMD): CNTNAP4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNTNAP4
    DNA2.0 Custom Variant and Variant Library Synthesis for CNTNAP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CNTNAP4 for disorders           About GeneDecksing

    OMIM gene information: 610518    OMIM disorders: --

    5 diseases for CNTNAP4:    About MalaCards
    primary open anle glaucoma    parkinson's disease    glaucoma    breast cancer
    cholesterol

    Human Genome Epidemiology (HuGE) Navigator: CNTNAP4 (3 documents)

    Export disorders for CNTNAP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNTNAP4 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with CNTNAP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Caspr3 and Caspr4, two novel members of the Caspr family are expressed in the nervous system and interact with PDZ domains. (PubMed id 12093160)1, 3 Spiegel I.... Peles E. (2002)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    3. Genome-wide analysis of central corneal thickness in p rimary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia. (PubMed id 22661486)1 Ulmer M....Hauser M.A. (2012)
    4. Genome-wide association study identifies novel loci as sociated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1 Demirkan A....Schmitz G. (2012)
    5. Investigation of single nucleotide polymorphisms and b iological pathways associated with response to TNFa inhibitors in patients with rheumatoid arthritis. (PubMed id 22569225)1 Krintel S.B....Hetland M.L. (2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1 Dastani Z....Genest J. (2010)
    8. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PubMed id 18398821)1 Nordgard S.H....Kristensen V.N. (2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85445 HGNC: 18747 AceView: CNTNAP4 Ensembl:ENSG00000152910 euGenes: HUgn85445
    ECgene: CNTNAP4 H-InvDB: CNTNAP4

    (According to HUGE)
    About This Section
    HUGE: KIAA1763

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNTNAP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNTNAP4 gene:
    Search GeneIP for patents involving CNTNAP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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