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Aliases for CNTNAP3B Gene

Aliases for CNTNAP3B Gene

  • Contactin Associated Protein-Like 3B 2 3
  • Cell Recognition Molecule Caspr3b 4
  • CASPR3B 4

External Ids for CNTNAP3B Gene

Summaries for CNTNAP3B Gene

GeneCards Summary for CNTNAP3B Gene

CNTNAP3B (Contactin Associated Protein-Like 3B) is a Protein Coding gene. An important paralog of this gene is CNTNAP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTNAP3B Gene

Genomics for CNTNAP3B Gene

Genomic Location for CNTNAP3B Gene

Start:
41,890,314 bp from pter
End:
42,129,510 bp from pter
Size:
239,197 bases
Orientation:
Minus strand

Genomic View for CNTNAP3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNTNAP3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTNAP3B Gene

No data available for Regulatory Elements for CNTNAP3B Gene

Proteins for CNTNAP3B Gene

  • Protein details for CNTNAP3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NU0-CNT3B_HUMAN
    Recommended name:
    Contactin-associated protein-like 3B
    Protein Accession:
    Q96NU0
    Secondary Accessions:
    • B1B0V7
    • B1B0V8
    • B1B0V9
    • B1B0W0
    • B1B0X8
    • B1B162
    • Q4VXF0
    • Q9H7W3

    Protein attributes for CNTNAP3B Gene

    Size:
    1288 amino acids
    Molecular mass:
    140468 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene encoding CNTNAP3B is the result of a pericentromeric duplication of the genomic region encoding CNTNAP3 on chromosome 9
    SequenceCaution:
    • Sequence=CAI12626.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16324.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95046.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95048.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95321.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CNTNAP3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNTNAP3B Gene

Proteomics data for CNTNAP3B Gene at MOPED

Post-translational modifications for CNTNAP3B Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn359 and Asn706

No data available for DME Specific Peptides for CNTNAP3B Gene

Domains for CNTNAP3B Gene

UniProtKB/Swiss-Prot:

CNT3B_HUMAN
Domain:
  • Contains 2 EGF-like domains.:
    • Q96NU0
  • Contains 1 F5/8 type C domain.:
    • Q96NU0
  • Contains 1 fibrinogen C-terminal domain.:
    • Q96NU0
  • Contains 4 laminin G-like domains.:
    • Q96NU0
Family:
  • Belongs to the neurexin family.:
    • Q96NU0
genes like me logo Genes that share domains with CNTNAP3B: view

No data available for Gene Families for CNTNAP3B Gene

Function for CNTNAP3B Gene

Gene Ontology (GO) - Molecular Function for CNTNAP3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CNTNAP3B: view

miRNA for CNTNAP3B Gene

miRTarBase miRNAs that target CNTNAP3B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNTNAP3B Gene

Localization for CNTNAP3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTNAP3B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNTNAP3B Gene COMPARTMENTS Subcellular localization image for CNTNAP3B gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CNTNAP3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNTNAP3B: view

Pathways for CNTNAP3B Gene

SuperPathways for CNTNAP3B Gene

No Data Available

Interacting Proteins for CNTNAP3B Gene

Gene Ontology (GO) - Biological Process for CNTNAP3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CNTNAP3B: view

No data available for Pathways by source for CNTNAP3B Gene

Transcripts for CNTNAP3B Gene

mRNA/cDNA for CNTNAP3B Gene

(29) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNTNAP3B Gene

Contactin associated protein-like 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNTNAP3B Gene

No ASD Table

Relevant External Links for CNTNAP3B Gene

GeneLoc Exon Structure for
CNTNAP3B
ECgene alternative splicing isoforms for
CNTNAP3B

Expression for CNTNAP3B Gene

mRNA expression in normal human tissues for CNTNAP3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTNAP3B Gene

This gene is overexpressed in Esophagus - Muscularis (5.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CNTNAP3B Gene

SOURCE GeneReport for Unigene cluster for CNTNAP3B Gene Hs.521495

genes like me logo Genes that share expressions with CNTNAP3B: view

Orthologs for CNTNAP3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNTNAP3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTNAP3B 36
  • 99.09 (n)
  • 98.84 (a)
CNTNAP3B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 40 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 45 (a)
ManyToMany
CNTNAP3 36
  • 78.14 (n)
  • 72.31 (a)
mouse
(Mus musculus)
Mammalia Cntnap3 37
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 37
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CR382299.1 37
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
OneToMany
Species with no ortholog for CNTNAP3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNTNAP3B Gene

ENSEMBL:
Gene Tree for CNTNAP3B (if available)
TreeFam:
Gene Tree for CNTNAP3B (if available)

Paralogs for CNTNAP3B Gene

Paralogs for CNTNAP3B Gene

Selected SIMAP similar genes for CNTNAP3B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CNTNAP3B Gene

genes like me logo Genes that share paralogs with CNTNAP3B: view

Variants for CNTNAP3B Gene

Sequence variations from dbSNP and Humsavar for CNTNAP3B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1378859 -- 42,130,124(+) GGAGG(C/T)GGGAG upstream-variant-2KB
rs1609765 -- 42,127,241(+) AGTCC(A/G)TTTGG intron-variant
rs1609766 -- 42,127,291(+) TCACT(A/G)TAAAT intron-variant
rs1620344 -- 41,965,526(+) CCCAC(C/T)TCTGC intron-variant
rs1621163 -- 41,965,616(+) AGATT(C/T)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNTNAP3B Gene

Variant ID Type Subtype PubMed ID
dgv8190n71 CNV Gain+Loss 21882294
esv2738445 CNV Deletion 23290073
nsv893173 CNV Gain 21882294
esv2677102 CNV Deletion 23128226
nsv436621 CNV Deletion 17901297
nsv8483 CNV Gain 18304495
dgv2342e1 CNV Complex 17122850
nsv436091 CNV Insertion 17901297
nsv515142 CNV Complex 21397061
nsv442543 CNV CNV 18776908
nsv893178 CNV Gain+Loss 21882294
nsv893179 CNV Gain+Loss 21882294
nsv821662 CNV Gain 15273396
nsv893181 CNV Gain 21882294
nsv893182 CNV Loss 21882294
nsv893183 CNV Loss 21882294
nsv831568 CNV Gain+Loss 17160897
dgv2346e1 CNV Complex 17122850
dgv2347e1 CNV Complex 17122850
dgv8192n71 CNV Gain 21882294
dgv1342e199 CNV Deletion 23128226
esv2676631 CNV Deletion 23128226
dgv8193n71 CNV Loss 21882294
dgv8194n71 CNV Gain 21882294
dgv8195n71 CNV Gain+Loss 21882294
dgv8196n71 CNV Loss 21882294
dgv8197n71 CNV Gain+Loss 21882294
dgv8198n71 CNV Gain+Loss 21882294
nsv824930 CNV Loss 20364138
dgv8199n71 CNV Gain+Loss 21882294
dgv8200n71 CNV Gain+Loss 21882294
dgv8201n71 CNV Gain 21882294
dgv1343e199 CNV Deletion 23128226
dgv8202n71 CNV Gain+Loss 21882294
nsv893214 CNV Loss 21882294
dgv8203n71 CNV Gain 21882294
dgv8204n71 CNV Gain 21882294
esv2659924 CNV Deletion 23128226
nsv893231 CNV Gain+Loss 21882294
dgv8205n71 CNV Gain+Loss 21882294
dgv8206n71 CNV Gain 21882294
dgv8207n71 CNV Gain 21882294
dgv8208n71 CNV Gain 21882294
dgv8209n71 CNV Gain+Loss 21882294
dgv8210n71 CNV Gain 21882294
dgv8211n71 CNV Loss 21882294
dgv8212n71 CNV Loss 21882294
nsv893269 CNV Gain+Loss 21882294
dgv8213n71 CNV Gain+Loss 21882294
nsv893276 CNV Loss 21882294
nsv824933 CNV Loss 20364138
esv22739 CNV Gain+Loss 19812545
nsv893279 CNV Gain 21882294
dgv8214n71 CNV Gain+Loss 21882294

Relevant External Links for CNTNAP3B Gene

HapMap Linkage Disequilibrium report
CNTNAP3B

Disorders for CNTNAP3B Gene

No disorders were found for CNTNAP3B Gene.

No data available for UniProtKB/Swiss-Prot for CNTNAP3B Gene

Publications for CNTNAP3B Gene

  1. A reciprocal translocation 46,XY,t(8;9)(p11.2;q13) in a bladder exstrophy patient disrupts CNTNAP3 and presents evidence of a pericentromeric duplication on chromosome 9. (PMID: 15820314) Boyadjiev S.A. … Stetten G. (Genomics 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for CNTNAP3B Gene

Sources for CNTNAP3B Gene

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