CNTNAP3B Gene
protein-coding GIFtS : 35
GCID: GC09 P043624
contactin associated protein-like 3B
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Aliasesfor CNTNAP3B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Contactin Associated Protein-Like 3B 1 2 Cell Recognition Molecule Caspr3b2 3 Contactin-Associated Protein-Like 3B2 CASPR3B3
Export aliases for CNTNAP3B gene to outside databases Previous GC identifer: GC09M040099
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Summariesfor CNTNAP3B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor CNTNAP3B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_167188.1 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for CNTNAP3B Other transcription factors Search SABiosciences Chromatin IP Primers for CNTNAP3B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTNAP3B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9p11.2 Ensembl cytogenetic band: 9p11.2 HGNC cytogenetic band: 9p12 CNTNAP3B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09P043624: view genomic region
(about GC identifiers )
Start:
43,684,885 bp from pter
End:
43,924,049 bp from pter
Size:
239,165 bases
Orientation:
plus strand
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Proteinsfor CNTNAP3B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CNT3B_HUMAN, Q96NU0 (See
protein sequence )Recommended Name: Contactin-associated protein-like 3B precursor Size : 1288 amino acids; 140468 Da
Subcellular location : Membrane; Single-pass type I membrane protein (Potential)
Miscellaneous : The gene encoding CNTNAP3B is the result of a pericentromeric duplication of the genomic region encodingCNTNAP3 on chromosome 9
Sequence caution : Sequence=CAI12626.1; Type=Erroneous gene model prediction; Sequence=CAI16324.1; Type=Erroneous genemodel prediction; Sequence=CAI95046.1; Type=Erroneous gene model prediction; Sequence=CAI95048.1; Type=Erroneous gene model prediction; Sequence=CAI95321.1; Type=Erroneous gene model prediction;
Secondary accessions : B1B0V7 B1B0V8 B1B0V9 B1B0W0 B1B0X8 B1B162 Q4VXF0 Q9H7W3Alternative splicing : 4 isoforms : Q96NU0-1 Q96NU0-2 Q96NU0-3 Q96NU0-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CNTNAP3B: NX_Q96NU0 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96NU0 CNTNAP3B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001188309.1 ENSEMBL proteins: ENSP00000366787 ENSP00000276974 ENSP00000340890 ENSP00000432883 ENSP00000366784 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
CNTNAP3B for ontologies About GeneDecksing CNTNAP3B Antibody Products: Assay Products for CNTNAP3B:
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Protein
Domains / Familiesfor CNTNAP3B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CNTNAP3B for domains About GeneDecksing 5/8 InterPro domains/families (see all 8 ):
Graphical View of Domain Structure for InterPro Entry Q96NU0 ProtoNet protein and cluster: Q96NU0
2 Blocks protein families : IPB000421 Coagulation factor 5/8 type C domain (FA58C) IPB001791 Laminin G UniProtKB/Swiss-Prot: CNT3B_HUMAN, Q96NU0 Similarity : Belongs to the neurexin familySimilarity : Contains 2 EGF-like domainsSimilarity : Contains 1 F5/8 type C domainSimilarity : Contains 1 fibrinogen C-terminal domainSimilarity : Contains 4 laminin G-like domains
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Functionfor CNTNAP3B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTNAP3B
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005102 receptor binding
IEA --
CNTNAP3B for ontologies About GeneDecksing
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Pathways & Interactionsfor CNTNAP3B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNTNAP3B Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007155 cell adhesion
IEA -- GO:0007165 signal transduction
IEA --
CNTNAP3B for ontologies About GeneDecksing
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Drugs & Compoundsfor CNTNAP3B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CNTNAP3B Search CenterWatch for drugs/clinical trials and news about CNTNAP3B / CNT3B
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Transcriptsfor CNTNAP3B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CNTNAP3B gene: NM_001201380.1 Unigene Cluster for CNTNAP3B:
Contactin associated protein-like 3B Hs.521495 [show with all ESTs ] Unigene Representative Sequence: NM_001201380 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000377564 (uc004acz.2 uc004ada.2 uc004adb.3 ) ENST00000276974 ENST00000341990 ENST00000479351 ENST00000377561 ENST00000491438 ENST00000489789 ENST00000476961 ENST00000480466 ENST00000484254 ENST00000467854 Additional cDNA sequence: AK054645.1 BX538190.1
13 DOTS entries : DT.410061 DT.101979763
DT.121169683 DT.121183169 DT.40302131 DT.121152811 DT.121169685 DT.121169690 DT.100780858 DT.121154825 DT.121157133 DT.121169679 DT.95262953 GeneLoc Exon Structure
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Expression for CNTNAP3B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CNTNAP3B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAACCACCAT
About this image CNTNAP3B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See CNTNAP3B Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.521495 SABiosciences Custom PCR Arrays for CNTNAP3B Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CNTNAP3B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CNTNAP3B Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTNAP3B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTNAP3B
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Orthologsfor CNTNAP3B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CNTNAP3B gene from 1/11 species (see all 11 ) About this table
ENSEMBL Gene Tree for CNTNAP3B (if available)TreeFam Gene Tree for CNTNAP3B (if available)
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Paralogsfor CNTNAP3B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CNTNAP3B gene CNTNAP1 2 NRXN3 2 CNTNAP5 2 NRXN2 2 LOC643792 2 CNTNAP3 2 CNTNAP4 2 CNTNAP2 2 NRXN1 2 7 SIMAP similar genes for CNTNAP3B using alignment to 3 protein entries: CNT3B_HUMAN (see all proteins ):CNTNAP3 CASPR4 DKFZp686I15204 CNTNAP4 CNTNAP2 CNTNAP5 CNTNAP1
CNTNAP3B for paralogs About GeneDecksing 3 Pseudogenes.org Pseudogenes for CNTNAP3B PGOHUM00000236048 PGOHUM00000236055 PGOHUM00000236473
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Genomic Variantsfor CNTNAP3B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CNTNAP3B (43684885 - 43924049 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CNTNAP3B: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CNTNAP3B
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Disorders
/ Diseasesfor CNTNAP3B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor CNTNAP3B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CNTNAP3B gene integrated from 9 sources : (articles sorted by number of sources associating them with CNTNAP3B) Utopia : connect your pdf to the dynamic world of online information
A reciprocal translocation 46,XY,t(8;9)(p11.2;q13) in a bladder exstrophy patient disrupts CNTNAP3 and presents evidence of a pericentromeric duplication on chromosome 9. (PubMed id 15820314) 1 , 2 , 3 Boyadjiev S.A.... Stetten G. (2005) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 1 , 2 Humphray S.J.... Dunham I. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011)
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External Searches for CNTNAP3B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CNTNAP3B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CNTNAP3B gene
(According to HUGE )
About This Section --
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Specialized Databases showing CNTNAP3B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CNTNAP3B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CNTNAP3B gene: Search GeneIP for patents involving CNTNAP3B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CNTNAP3B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNTNAP3B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CNTNAP3B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTNAP3B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CNTNAP3B Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTNAP3B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CNTNAP3B
CNTNAP3B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTNAP3B
Search ThermoFisher Antibodies for CNTNAP3B
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CNTNAP3B
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Function for CNTNAP3B
Genomic Views for CNTNAP3B
Intellectual Property for CNTNAP3B
Orthologs for CNTNAP3B
Paralogs for CNTNAP3B
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