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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNTNAP1 Gene

protein-coding   GIFtS: 59
GCID: GC17P040835

Contactin Associated Protein 1


(Previous symbol: NRXN4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Contactin Associated Protein 11 2     caspr12
NRXN41 2 3 5     Contactin-Associated Protein 12
CASPR2 3 5     neurexin-42
Neurexin 41 2     Caspr3
Neurexin IV2 3     Caspr13
P1902 5     Neurexin-43
CNTNAP2     p1903

External Ids:    HGNC: 80111   Entrez Gene: 85062   Ensembl: ENSG000001087977   OMIM: 6023465   UniProtKB: P783573   

Export aliases for CNTNAP1 gene to outside databases

Previous GC identifers: GC17P040350 GC17P042999 GC17P040743 GC17P041207 GC17P038088 GC17P036601


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNTNAP1 Gene:
The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The
1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an
extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain,
and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly
in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its
extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin,
enabling recruitment and activation of intracellular signaling pathways in neurons. (provided by RefSeq, Jan
2009)

GeneCards Summary for CNTNAP1 Gene: 
CNTNAP1 (contactin associated protein 1) is a protein-coding gene. Diseases associated with CNTNAP1 include juvenile astrocytoma, and inherited peripheral neuropathy, and among its related super-pathways are Axon guidance. GO annotations related to this gene include SH3 domain binding and receptor binding. An important paralog of this gene is NRXN3.

UniProtKB/Swiss-Prot: CNTP1_HUMAN, P78357
Function: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction
of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction.
In association with contactin may have a role in the signaling between axons and myelinating glial cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNTNAP1 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNTNAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNTNAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTNAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21

CNTNAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNTNAP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040835:  view genomic region     (about GC identifiers)

Start:
40,834,631 bp from pter      End:
40,852,011 bp from pter
Size:
17,381 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNTP1_HUMAN, P78357 (See protein sequence)
Recommended Name: Contactin-associated protein 1 precursor  
Size: 1384 amino acids; 156267 Da
Subunit: Interacts with contactin in cis form
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Explore the universe of human proteins at neXtProt for CNTNAP1: NX_P78357

Explore proteomics data for CNTNAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78357

  • CNTNAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNTNAP1 Protein Expression
    REFSEQ proteins: NP_003623.1  
    ENSEMBL proteins: 
     ENSP00000264638   ENSP00000466571  
    Reactome Protein details: P78357
    Human Recombinant Protein Products for CNTNAP1: 
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    Novus Biologicals CNTNAP1 Protein
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for CNTNAP1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9118959
    GO:0008076colocalizes with voltage-gated potassium channel complex ISS--
    GO:0030424axon ----
    GO:0033270paranode region of axon ISS--

    CNTNAP1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CNTNAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR008979 Galactose-bd-like

    Graphical View of Domain Structure for InterPro Entry P78357

    ProtoNet protein and cluster: P78357

    4 Blocks protein domains:
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB001791 Laminin G
    IPB003585 Neurexin/syndecan/glycophorin C
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: CNTP1_HUMAN, P78357
    Similarity: Belongs to the neurexin family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 F5/8 type C domain
    Similarity: Contains 1 fibrinogen C-terminal domain
    Similarity: Contains 4 laminin G-like domains


    CNTNAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNTP1_HUMAN, P78357
    Function: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction
    of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction.
    In association with contactin may have a role in the signaling between axons and myelinating glial cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9118959
    GO:0005070SH3/SH2 adaptor activity TAS9118959
    GO:0005515protein binding IPI17474147
    GO:0017124SH3 domain binding IEA--
         
    CNTNAP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CNTNAP1:
     Increased Salmonella enterica   Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Cntnap1):
     behavior/neurological  growth/size  mortality/aging  muscle  nervous system 
     reproductive system  skeleton  vision/eye 

    CNTNAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CNTNAP1: Cntnap1tm1Pele Ccr10/Cntnap1Ccr10/tm1Bhat

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNTNAP1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNTNAP1 
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    SwitchGear 3'UTR luciferase reporter plasmidCNTNAP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CNTNAP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    2Neurofascin interactions
    Neurofascin interactions
    3Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for CNTNAP1
        L1CAM interactions
    Developmental Biology
    Axon guidance
    Neurofascin interactions


    1         Kegg Pathway  (Kegg details for CNTNAP1):
        Cell adhesion molecules (CAMs)


    CNTNAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNTNAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/17 Interacting proteins for CNTNAP1 (P783571, 2, 3 ENSP000002646384) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8111055 I2D: score=4 STRING: ENSP00000357656
    ABL1P005192, 3, ENSP000003614234MINT-8110155 I2D: score=3 STRING: ENSP00000361423
    NCK1P163331, 3, ENSP000002889864EBI-1751903,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002175protein localization to paranode region of axon ISS--
    GO:0007010cytoskeleton organization ISS--
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS9118959
    GO:0007411axon guidance TAS--

    CNTNAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CNTNAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNTNAP1 (CNTP1)

    4 Novoseek inferred chemical compound relationships for CNTNAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 41.1 3 11588184 (1), 18342527 (1), 12401452 (1)
    potassium 23.1 3 10664064 (1), 11512672 (1), 12401452 (1)
    phosphatidylinositol 16.2 2 11069942 (1)
    tyrosine 1.98 6 9417037 (4), 8524223 (1)

    Search CenterWatch for drugs/clinical trials and news about CNTNAP1 / CNTP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNTNAP1 gene: 
    NM_003632.2  

    Unigene Cluster for CNTNAP1:

    Contactin associated protein 1
    Hs.408730  [show with all ESTs]
    Unigene Representative Sequence: NM_003632
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264638(uc002iay.3 uc010wgs.2) ENST00000591662 ENST00000586801
    ENST00000585534
    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate CNTNAP1 (see all 42):
    hsa-miR-15a hsa-miR-503 hsa-miR-3921 hsa-miR-449a hsa-miR-424 hsa-miR-3613-3p hsa-miR-186 hsa-miR-15b
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    Additional mRNA sequence: 

    BC171797.1 U87223.1 

    5 DOTS entries:

    DT.443400  DT.95089021  DT.40131474  DT.97776246  DT.99935181 

    24/88 AceView cDNA sequences (see all 88):

    AW952368 AI085318 AI149166 BI870193 AI313414 AI126334 AA325604 U87223 
    AL706048 BU170662 BQ718897 BU726587 CD617298 NM_003632 BM551800 BU729460 
    BM719221 CD617291 BU632710 BQ723531 BM708066 BV170614 BE933659 CO247738 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNTNAP1 expression in normal human tissues (normalized intensities)      CNTNAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAACCCTC
    CNTNAP1 Expression
    About this image


    CNTNAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Blood (Hematopoietic System)
             Peripheral blood-derived hematopoietic stem cells
     
     Eye (Sensory Organs)
             retinal progenitor cell p0   
     
     Larynx (Respiratory System)

    See CNTNAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNTNAP1

    SOURCE GeneReport for Unigene cluster: Hs.408730

    UniProtKB/Swiss-Prot: CNTP1_HUMAN, P78357
    Tissue specificity: Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung,
    heart, intestine and testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTNAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CNTNAP1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cntnap11 , 5 contactin associated protein-like 11, 5 87.91(n)1
    93.35(a)1
      11 (64.33 cM)5
    533211  NM_016782.21  NP_058062.21 
     1011705235 
    chicken
    (Gallus gallus)
    Aves CNTNAP11 contactin associated protein 1 70.25(n)
    66.98(a)
      428309  XM_003642826.1  XP_003642874.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNTNAP16
    --
    --
    60(a)
    35(a)
    1 ↔ 1
    possible ortholog
    6(61899126-61940516)
    2(38260894-38592818)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5662201 contactin-associated protein 1-like 57.33(n)
    51.39(a)
      566220  XM_689488.4  XP_694580.4 


    ENSEMBL Gene Tree for CNTNAP1 (if available)
    TreeFam Gene Tree for CNTNAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNTNAP1 gene
    NRXN32  CNTNAP52  NRXN22  CNTNAP3B2  CNTNAP32  LOC6437922  CNTNAP42  CNTNAP22  
    NRXN12  
    9 SIMAP similar genes for CNTNAP1 using alignment to 3 protein entries:     CNTP1_HUMAN (see all proteins):
    CNTNAP2    CASPR4    CNTNAP4    CNTNAP5    CNTNAP3    CNTNAP3B
    EGFLAM    SHBG    WUGSC

    CNTNAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/455 SNPs in CNTNAP1 are shown (see all 455)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909124961,2
    --40835896(+) CTCCTA/CCTACT 2 Y S mis10--------
    rs22710291,2
    C,F,O,A,H--40835922(+) CGCCGC/AGATTC 2 /R syn1 ese332Minor allele frequency- A:0.41NA NS EA WA CSA EU 8429
    rs1395033911,2
    C--40836028(+) TAGCCG/TGTTAA 1 -- int10--------
    rs1155525831,2
    C,F--40836211(+) GTGGAC/TAGCTG 2 D syn11Minor allele frequency- T:0.01NA 4552
    rs2011280631,2
    C--40836258(+) CTGGGC/AGCCAA 1 -- int11Minor allele frequency- A:0.00EU 629
    rs1148715541,2
    C--40836262(+) GCGCCA/CAGGCG 1 -- int12Minor allele frequency- C:0.02WA EU 735
    rs65037181,2
    C--40836374(+) CTCCAC/TTCCAG 1 -- int113Minor allele frequency- T:0.01NA WA CSA EA 377
    rs728269621,2
    C--40836389(+) TCTGTC/TCAGAG 1 -- int10--------
    rs72238281,2
    C,F--40836452(+) ACTTTA/GGGGTA 1 -- int12Minor allele frequency- G:0.13WA 120
    rs1828123461,2
    --40836482(+) AAGGAA/GGTGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CNTNAP1 (40834631 - 40852011 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CNTNAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1007587CNV Deletion20482838
    nsv833450CNV Loss17160897
    esv33998OTHER Inversion15654335

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602346    OMIM disorders: --

    11 diseases for CNTNAP1:    About MalaCards
    juvenile astrocytoma    inherited peripheral neuropathy    peripheral neuropathy    encephalomyelitis
    neuropathy    meningioma    multiple sclerosis    astrocytoma
    neuronitis    breast cancer    leukemia


    CNTNAP1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CNTNAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    demyelination 41.1 2 12805111 (1)

    Genetic Association Database (GAD): CNTNAP1
    Human Genome Epidemiology (HuGE) Navigator: CNTNAP1 (6 documents)

    Export disorders for CNTNAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNTNAP1 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with CNTNAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. (PubMed id 9118959)1, 2, 3 Peles E.... Schlessinger J. (1997)
    2. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    3. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    4. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. (PubMed id 19372141)1, 4 Lee J.Y....Kang D. (2009)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    6. Caspr1/Paranodin/Neurexin IV is most likely not a common disease-causing gene for inherited peripheral neuropathies. (PubMed id 11496158)1, 9 Venken K....Timmerman V. (2001)
    7. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initia tive SHARe Study. (PubMed id 23192594)1 Velez Edwards D.R....Edwards T.L. (2013)
    8. Identification of novel g-secretase-associated protein s in detergent-resistant membranes from brain. (PubMed id 22315232)1 Hur J.Y....Tjernberg L.O. (2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    10. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8506 HGNC: 8011 AceView: CNTNAP1 Ensembl:ENSG00000108797 euGenes: HUgn8506
    ECgene: CNTNAP1 Kegg: 8506 H-InvDB: CNTNAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNTNAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNTNAP1 gene:
    Search GeneIP for patents involving CNTNAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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