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Aliases for CNTN5 Gene

Aliases for CNTN5 Gene

  • Contactin 5 2 3
  • Neural Recognition Molecule NB-2 3 4
  • Neural Adhesion Molecule 3
  • Contactin-5 3
  • HNB-2s 3
  • HNB-2 4
  • NB-2 3
  • NB2 6

External Ids for CNTN5 Gene

Previous GeneCards Identifiers for CNTN5 Gene

  • GC11P101085
  • GC11P100784
  • GC11P098429
  • GC11P098397
  • GC11P094826

Summaries for CNTN5 Gene

Entrez Gene Summary for CNTN5 Gene

  • The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CNTN5 Gene

CNTN5 (Contactin 5) is a Protein Coding gene. An important paralog of this gene is PRTG.

UniProtKB/Swiss-Prot for CNTN5 Gene

  • Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTN5 Gene

Genomics for CNTN5 Gene

Genomic Location for CNTN5 Gene

99,020,953 bp from pter
100,358,885 bp from pter
1,337,933 bases
Plus strand

Genomic View for CNTN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNTN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTN5 Gene

Proteins for CNTN5 Gene

  • Protein details for CNTN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1L4P0
    • B7ZM07
    • E9PKE8
    • O94780
    • Q49AF3

    Protein attributes for CNTN5 Gene

    1100 amino acids
    Molecular mass:
    120686 Da
    Quaternary structure:
    • Interacts with PTPRG.
    • Sequence=AAH39255.1; Type=Erroneous termination; Positions=223; Note=Translated as Ser.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNTN5 Gene

    Alternative splice isoforms for CNTN5 Gene


neXtProt entry for CNTN5 Gene

Proteomics data for CNTN5 Gene at MOPED

Post-translational modifications for CNTN5 Gene

  • Glycosylation at Asn138, Asn196, Asn397, Asn449, Asn540, Asn779, Asn816, Asn931, and Asn1002
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CNTN5 Gene

Domains for CNTN5 Gene

Protein Domains for CNTN5 Gene

Suggested Antigen Peptide Sequences for CNTN5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 fibronectin type-III domains.
  • Belongs to the immunoglobulin superfamily. Contactin family.
  • Contains 4 fibronectin type-III domains.
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. Contactin family.
genes like me logo Genes that share domains with CNTN5: view

Function for CNTN5 Gene

Molecular function for CNTN5 Gene

UniProtKB/Swiss-Prot Function:
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity).

Gene Ontology (GO) - Molecular Function for CNTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CNTN5: view

Phenotypes for CNTN5 Gene

genes like me logo Genes that share phenotypes with CNTN5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNTN5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CNTN5 Gene

Localization for CNTN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTN5 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for CNTN5 Gene COMPARTMENTS Subcellular localization image for CNTN5 gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 3
nucleus 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CNTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CNTN5: view

Pathways for CNTN5 Gene

SuperPathways for CNTN5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007605 sensory perception of sound IEA --
genes like me logo Genes that share ontologies with CNTN5: view

No data available for Pathways by source for CNTN5 Gene

Transcripts for CNTN5 Gene

Unigene Clusters for CNTN5 Gene

Contactin 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNTN5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTN5 Gene

No ASD Table

Relevant External Links for CNTN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNTN5 Gene

mRNA expression in normal human tissues for CNTN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTN5 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (8.1), Brain - Amygdala (8.0), Brain - Frontal Cortex (BA9) (7.4), Brain - Hippocampus (6.0), and Brain - Cortex (5.5).

Protein differential expression in normal tissues for CNTN5 Gene

This gene is overexpressed in Plasma (42.1), Heart (13.0), and Fetal Brain (11.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CNTN5 Gene

SOURCE GeneReport for Unigene cluster for CNTN5 Gene Hs.656783

mRNA Expression by UniProt/SwissProt for CNTN5 Gene

Tissue specificity: Expressed in brain and kidney and at very low level in placenta. Not expressed in other tissues. In brain, it is highly expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus and temporal lobe. Expressed at moderate level in the cerebellum, substantia nigra, putamen, medulla and hippocampus. Weakly expressed in the spinal cord and caudate nucleus. Weakly or not expressed in the corpus callosum.
genes like me logo Genes that share expressions with CNTN5: view

Expression partners for CNTN5 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CNTN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNTN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CNTN5 35
  • 92.3 (n)
  • 94.64 (a)
CNTN5 36
  • 95 (a)
(Mus musculus)
Mammalia Cntn5 35
  • 85.91 (n)
  • 89.98 (a)
Cntn5 16
Cntn5 36
  • 91 (a)
(Pan troglodytes)
Mammalia CNTN5 35
  • 99.55 (n)
  • 99.36 (a)
CNTN5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cntn5 35
  • 85.56 (n)
  • 90.45 (a)
(Bos Taurus)
Mammalia -- 36
  • 23 (a)
(Monodelphis domestica)
Mammalia CNTN5 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia CNTN5 36
  • 88 (a)
(Gallus gallus)
Aves CNTN5 35
  • 80.19 (n)
  • 86.9 (a)
FAR-2 36
  • 85 (a)
(Anolis carolinensis)
Reptilia CNTN5 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cntn5 35
  • 74.32 (n)
  • 78.58 (a)
(Danio rerio)
Actinopterygii cntn5 35
  • 64.81 (n)
  • 67.26 (a)
wufi09g01 35
cntn5 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cont 37
  • 31 (a)
(Caenorhabditis elegans)
Secernentea C33F10.5a 37
  • 23 (a)
C33F10.5b 37
  • 23 (a)
Y54G2A.25 37
  • 28 (a)
Species with no ortholog for CNTN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNTN5 Gene

Gene Tree for CNTN5 (if available)
Gene Tree for CNTN5 (if available)

Paralogs for CNTN5 Gene

(11) SIMAP similar genes for CNTN5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CNTN5: view

Variants for CNTN5 Gene

Sequence variations from dbSNP and Humsavar for CNTN5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3443 -- 100,358,696(-) AAACT(G/T)TTGCT utr-variant-3-prime
rs282484 -- 99,333,974(+) CTCTC(A/T)CACAC intron-variant
rs282485 -- 99,334,282(+) ATTCA(A/G)TGAAT intron-variant
rs282486 -- 99,337,409(+) cagtc(A/G)ttagc intron-variant
rs282487 -- 99,319,746(+) ttgca(A/G)tttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNTN5 Gene

Variant ID Type Subtype PubMed ID
nsv832242 CNV Loss 17160897
nsv428265 CNV Loss 18775914
nsv898263 CNV Gain 21882294
nsv898264 CNV Gain 21882294
nsv468823 CNV Loss 19166990
nsv469984 CNV Loss 18288195
dgv1289n71 CNV Loss 21882294
esv33558 CNV Gain 17666407
dgv1290n71 CNV Loss 21882294
esv32699 CNV Loss 17666407
dgv1291n71 CNV Loss 21882294
nsv525174 CNV Loss 19592680
nsv516785 CNV Loss 19592680
nsv517422 CNV Loss 19592680
nsv898272 CNV Loss 21882294
nsv520993 CNV Loss 19592680
nsv524013 CNV Loss 19592680
nsv898273 CNV Loss 21882294
esv2744966 CNV Deletion 23290073
esv2299250 CNV Deletion 18987734
esv2744967 CNV Deletion 23290073
esv1001289 CNV Deletion 20482838
esv1232702 CNV Deletion 17803354
nsv468824 CNV Loss 19166990
dgv427e1 CNV Complex 17122850
esv1003185 CNV Gain 20482838
nsv8866 CNV Loss 18304495
nsv898274 CNV Loss 21882294
nsv898275 CNV Gain 21882294
esv271810 CNV Insertion 20981092
esv273225 CNV Insertion 20981092
nsv521600 CNV Gain 19592680
dgv428e1 CNV Complex 17122850
dgv429e1 CNV Complex 17122850
nsv519381 CNV Loss 19592680
esv23115 CNV Loss 19812545
nsv826051 CNV Loss 20364138
dgv430e1 CNV Complex 17122850
esv2661704 CNV Deletion 23128226
esv2656838 CNV Deletion 23128226
nsv898276 CNV Loss 21882294
nsv898277 CNV Gain 21882294
esv1754839 CNV Insertion 17803354
dgv1292n71 CNV Loss 21882294
nsv526809 CNV Gain 19592680
esv2466796 CNV Deletion 19546169
esv2209043 CNV Deletion 18987734
esv4356 CNV Deletion 18987735
esv2744968 CNV Deletion 23290073
esv7509 CNV Loss 19470904
esv1322572 CNV Deletion 17803354
nsv468828 CNV Loss 19166990
nsv898280 CNV Loss 21882294
dgv1293n71 CNV Loss 21882294
dgv1294n71 CNV Loss 21882294
dgv1295n71 CNV Gain+Loss 21882294
dgv1296n71 CNV Loss 21882294
nsv468829 CNV Loss 19166990
nsv468830 CNV Loss 19166990
nsv468831 CNV Loss 19166990
nsv522201 CNV Loss 19592680
nsv526736 CNV Loss 19592680
nsv898297 CNV Loss 21882294
esv2662479 CNV Deletion 23128226
esv5885 CNV Gain 19470904
esv1223158 CNV Insertion 17803354
nsv507610 CNV Insertion 20534489
esv2744969 CNV Deletion 23290073
esv2744970 CNV Deletion 23290073
nsv898298 CNV Loss 21882294
nsv526965 CNV Gain 19592680
nsv468832 CNV Gain 19166990
dgv1297n71 CNV Loss 21882294
nsv818860 CNV Loss 17921354
nsv468833 CNV Loss 19166990
nsv468834 CNV Loss 19166990
nsv525366 CNV Loss 19592680
esv24648 CNV Gain 19812545
nsv821270 CNV Deletion 20802225
esv998217 CNV Gain 20482838
esv270060 CNV Insertion 20981092
esv2744971 CNV Deletion 23290073
esv2678709 CNV Deletion 23128226
dgv168n27 CNV Loss 19166990
nsv519340 CNV Loss 19592680
dgv1298n71 CNV Loss 21882294
nsv522053 CNV Loss 19592680
nsv520862 CNV Loss 19592680
nsv898303 CNV Gain 21882294
nsv517898 CNV Loss 19592680
nsv454 CNV Insertion 18451855
dgv1299n71 CNV Loss 21882294
nsv898306 CNV Loss 21882294
dgv1300n71 CNV Loss 21882294
nsv468842 CNV Loss 19166990
nsv826052 CNV Loss 20364138
nsv468843 CNV Loss 19166990
esv2661553 CNV Deletion 23128226
esv2421944 CNV Deletion 20811451
nsv528690 CNV Loss 19592680
dgv236e199 CNV Deletion 23128226
esv2438747 CNV Insertion 19546169
nsv826054 CNV Loss 20364138
esv1004847 CNV Insertion 20482838
nsv819915 CNV Loss 19587683
esv1010482 CNV Gain 20482838
nsv826055 CNV Loss 20364138
nsv513331 CNV Insertion 21212237
esv274186 CNV Insertion 20981092
esv267431 CNV Insertion 20981092
nsv832243 CNV Gain 17160897
nsv898311 CNV Loss 21882294
dgv1301n71 CNV Loss 21882294
nsv468844 CNV Loss 19166990
nsv898313 CNV Loss 21882294
dgv431e1 CNV Complex 17122850
essv19298 CNV CNV 17122850
nsv898315 CNV Loss 21882294
essv12429 CNV CNV 17122850
esv272105 CNV Insertion 20981092
dgv1302n71 CNV Loss 21882294
nsv526847 CNV Gain 19592680
nsv468845 CNV Loss 19166990
nsv469985 CNV Loss 18288195
nsv898318 CNV Loss 21882294
nsv456 CNV Insertion 18451855
esv2659055 CNV Deletion 23128226
nsv468846 CNV Loss 19166990
esv1010651 CNV Deletion 20482838
esv2744972 CNV Deletion 23290073
nsv468847 CNV Loss 19166990
nsv898319 CNV Loss 21882294
nsv469986 CNV Loss 18288195
dgv1303n71 CNV Loss 21882294
nsv832244 CNV Loss 17160897
nsv457 CNV Insertion 18451855
nsv832245 CNV Gain 17160897
nsv468848 CNV Loss 19166990
nsv520995 CNV Gain 19592680
nsv522847 CNV Gain 19592680

Relevant External Links for CNTN5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTN5 Gene

Disorders for CNTN5 Gene

(2) University of Copenhagen DISEASES for CNTN5 Gene

Relevant External Links for CNTN5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CNTN5: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CNTN5 Gene

Publications for CNTN5 Gene

  1. Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. (PMID: 11013081) Kamei Y. … Watanabe K. (Genomics 2000) 3 4 23
  2. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 3 48
  3. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. (PMID: 17903304) Larson M.G. … Levy D. (BMC Med. Genet. 2007) 3 48
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for CNTN5 Gene

Sources for CNTN5 Gene

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