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Aliases for CNTN3 Gene

Aliases for CNTN3 Gene

  • Contactin 3 2 3 5
  • Brain-Derived Immunoglobulin Superfamily Protein 1 3 4
  • Plasmacytoma-Associated Neuronal Glycoprotein 3 4
  • Contactin 3 (Plasmacytoma Associated) 2 3
  • BIG-1 3 4
  • PANG 3 4
  • KIAA1496 4
  • PCS 3

External Ids for CNTN3 Gene

Previous HGNC Symbols for CNTN3 Gene

  • PANG

Previous GeneCards Identifiers for CNTN3 Gene

  • GC03M072881
  • GC03M073925
  • GC03M074117
  • GC03M074394

Summaries for CNTN3 Gene

GeneCards Summary for CNTN3 Gene

CNTN3 (Contactin 3) is a Protein Coding gene. Diseases associated with CNTN3 include plasmacytoma and taylor's syndrome. An important paralog of this gene is DSCAML1.

UniProtKB/Swiss-Prot for CNTN3 Gene

  • Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).

Gene Wiki entry for CNTN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTN3 Gene

Genomics for CNTN3 Gene

Regulatory Elements for CNTN3 Gene

Enhancers for CNTN3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CNTN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNTN3 Gene

Chromosome:
3
Start:
74,262,568 bp from pter
End:
74,614,445 bp from pter
Size:
351,878 bases
Orientation:
Minus strand

Genomic View for CNTN3 Gene

Genes around CNTN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTN3 Gene

Proteins for CNTN3 Gene

  • Protein details for CNTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P232-CNTN3_HUMAN
    Recommended name:
    Contactin-3
    Protein Accession:
    Q9P232
    Secondary Accessions:
    • B9EK50
    • Q9H039

    Protein attributes for CNTN3 Gene

    Size:
    1028 amino acids
    Molecular mass:
    112883 Da
    Quaternary structure:
    • Interacts with PTPRG.

    Three dimensional structures from OCA and Proteopedia for CNTN3 Gene

neXtProt entry for CNTN3 Gene

Proteomics data for CNTN3 Gene at MOPED

Post-translational modifications for CNTN3 Gene

  • Glycosylation at Asn 65, Asn 193, Asn 375, Asn 468, Asn 489, Asn 765, Asn 860, Asn 895, Asn 913, Asn 931, and Asn 956
  • Modification sites at PhosphoSitePlus

Other Protein References for CNTN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CNTN3 Gene

Domains & Families for CNTN3 Gene

Protein Domains for CNTN3 Gene

Suggested Antigen Peptide Sequences for CNTN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P232

UniProtKB/Swiss-Prot:

CNTN3_HUMAN :
  • Contains 4 fibronectin type-III domains.
  • Belongs to the immunoglobulin superfamily. Contactin family.
Domain:
  • Contains 4 fibronectin type-III domains.
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. Contactin family.
genes like me logo Genes that share domains with CNTN3: view

Function for CNTN3 Gene

Molecular function for CNTN3 Gene

UniProtKB/Swiss-Prot Function:
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).
genes like me logo Genes that share phenotypes with CNTN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CNTN3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNTN3 Gene

Localization for CNTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTN3 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNTN3 Gene COMPARTMENTS Subcellular localization image for CNTN3 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CNTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CNTN3: view

Pathways & Interactions for CNTN3 Gene

SuperPathways for CNTN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CNTN3: view

No data available for Pathways by source and SIGNOR curated interactions for CNTN3 Gene

Drugs & Compounds for CNTN3 Gene

No Compound Related Data Available

Transcripts for CNTN3 Gene

Unigene Clusters for CNTN3 Gene

Contactin 3 (plasmacytoma associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNTN3 Gene

No ASD Table

Relevant External Links for CNTN3 Gene

GeneLoc Exon Structure for
CNTN3
ECgene alternative splicing isoforms for
CNTN3

Expression for CNTN3 Gene

mRNA expression in normal human tissues for CNTN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTN3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for CNTN3 Gene

This gene is overexpressed in Serum (32.2), Pancreas (14.6), Plasma (9.3), and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNTN3 Gene



SOURCE GeneReport for Unigene cluster for CNTN3 Gene Hs.12723

mRNA Expression by UniProt/SwissProt for CNTN3 Gene

Q9P232-CNTN3_HUMAN
Tissue specificity: In brain, it is expressed in frontal lobe, occipital lobe, cerebellum and amygdala.
genes like me logo Genes that share expression patterns with CNTN3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CNTN3 Gene

Orthologs for CNTN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNTN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNTN3 35
  • 90.4 (n)
  • 92.8 (a)
CNTN3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNTN3 35
  • 90.88 (n)
  • 93.67 (a)
CNTN3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cntn3 35
  • 88.23 (n)
  • 91.44 (a)
Cntn3 16
Cntn3 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNTN3 35
  • 99.29 (n)
  • 99.71 (a)
CNTN3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cntn3 35
  • 87.19 (n)
  • 90.66 (a)
oppossum
(Monodelphis domestica)
Mammalia CNTN3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNTN3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNTN3 35
  • 76.53 (n)
  • 82.54 (a)
CNTN3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNTN3 36
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC556251 35
  • 61.73 (n)
  • 59.66 (a)
CABZ01012080.1 36
  • 58 (a)
OneToMany
cntn3a.2 36
  • 57 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta IGL1 35
  • 24.77 (n)
  • 5.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cont 35
  • 43.46 (n)
  • 34.18 (a)
Species with no ortholog for CNTN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNTN3 Gene

ENSEMBL:
Gene Tree for CNTN3 (if available)
TreeFam:
Gene Tree for CNTN3 (if available)

Paralogs for CNTN3 Gene

(7) SIMAP similar genes for CNTN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNTN3: view

Variants for CNTN3 Gene

Sequence variations from dbSNP and Humsavar for CNTN3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs626578 -, - 74,299,911(+) CTCCA(C/T)TGACT reference, missense
rs733144 -- 74,569,137(-) TAGGC(A/G)TACAG intron-variant
rs1075109 -- 74,378,265(-) GTTAT(C/T)TGAAC intron-variant
rs1101685 -- 74,317,293(+) tccaa(C/T)ttgcc intron-variant
rs1101686 -- 74,317,357(+) tgtta(G/T)gtgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNTN3 Gene

Variant ID Type Subtype PubMed ID
nsv526832 CNV Gain 19592680
nsv876951 CNV Gain 21882294
nsv876954 CNV Gain 21882294
nsv834733 CNV Loss 17160897
nsv834734 CNV Loss 17160897
nsv526012 CNV Loss 19592680
esv268494 CNV Insertion 20981092
esv273937 CNV Insertion 20981092
esv2725408 CNV Deletion 23290073
esv2678039 CNV Deletion 23128226
esv273318 CNV Insertion 20981092

Variation tolerance for CNTN3 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.20; 80.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNTN3 Gene

HapMap Linkage Disequilibrium report
CNTN3
Human Gene Mutation Database (HGMD)
CNTN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTN3 Gene

Disorders for CNTN3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CNTN3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
plasmacytoma
  • myeloma - solitary
taylor's syndrome
  • congestion-fibrosis syndrome
pneumonic tularemia
  • bronchopneumonic tularemia
inhalation anthrax
  • pulmonary anthrax
carpal tunnel syndrome, familial
  • carpal tunnel syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CNTN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNTN3

Genetic Association Database (GAD)
CNTN3
Human Genome Epidemiology (HuGE) Navigator
CNTN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNTN3
genes like me logo Genes that share disorders with CNTN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNTN3 Gene

Publications for CNTN3 Gene

  1. Plasmacytoma-associated neuronal glycoprotein, Pang, maps to mouse chromosome 6 and human chromosome 3. (PMID: 8661054) Mock B.A. … Marcu K.B. (Genomics 1996) 2 3 23 67
  2. Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. (PMID: 11013081) Kamei Y. … Watanabe K. (Genomics 2000) 3 23
  3. Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. (PMID: 8586965) Yoshihara Y. … Mori K. (J. Neurobiol. 1995) 2 3
  4. Genome-wide association study of smoking behaviours among Bangladeshi adults. (PMID: 24665060) Argos M. … Ahsan H. (J. Med. Genet. 2014) 3
  5. The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin D.J. … Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3

Products for CNTN3 Gene

Sources for CNTN3 Gene

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