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Aliases for CNTN3 Gene

Aliases for CNTN3 Gene

  • Contactin 3 (Plasmacytoma Associated) 2 3
  • PANG 3 4 6
  • Brain-Derived Immunoglobulin Superfamily Protein 1 3 4
  • Plasmacytoma-Associated Neuronal Glycoprotein 3 4
  • BIG-1 3 4
  • Contactin-3 3
  • KIAA1496 4
  • PCS 3

External Ids for CNTN3 Gene

Previous Symbols for CNTN3 Gene

  • PANG

Summaries for CNTN3 Gene

GeneCards Summary for CNTN3 Gene

CNTN3 (Contactin 3 (Plasmacytoma Associated)) is a Protein Coding gene. An important paralog of this gene is PRTG.

UniProtKB/Swiss-Prot for CNTN3 Gene

  • Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).

Gene Wiki entry for CNTN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTN3 Gene

Genomics for CNTN3 Gene

Genomic Location for CNTN3 Gene

Start:
74,262,568 bp from pter
End:
74,614,436 bp from pter
Size:
351,869 bases
Orientation:
Minus strand

Genomic View for CNTN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTN3 Gene

Regulatory Elements for CNTN3 Gene

Proteins for CNTN3 Gene

  • Protein details for CNTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P232-CNTN3_HUMAN
    Recommended name:
    Contactin-3
    Protein Accession:
    Q9P232
    Secondary Accessions:
    • B9EK50
    • Q9H039

    Protein attributes for CNTN3 Gene

    Size:
    1028 amino acids
    Molecular mass:
    112883 Da
    Quaternary structure:
    • Interacts with PTPRG.

    Three dimensional structures from OCA and Proteopedia for CNTN3 Gene

neXtProt entry for CNTN3 Gene

Proteomics data for CNTN3 Gene at MOPED

Post-translational modifications for CNTN3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn65, Asn193, Asn375, Asn468, Asn489, Asn765, Asn860, Asn895, Asn913, Asn931, and Asn956

Other Protein References for CNTN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNTN3 Gene

Domains for CNTN3 Gene

Gene Families for CNTN3 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for CNTN3 Gene

UniProtKB/Swiss-Prot:

CNTN3_HUMAN
Domain:
  • Contains 4 fibronectin type-III domains.:
    • Q9P232
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q9P232
Family:
  • Belongs to the immunoglobulin superfamily. Contactin family.:
    • Q9P232
genes like me logo Genes that share domains with CNTN3: view

Function for CNTN3 Gene

Molecular function for CNTN3 Gene

UniProtKB/Swiss-Prot Function: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).

Gene Ontology (GO) - Molecular Function for CNTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CNTN3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CNTN3 Gene

Localization for CNTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTN3 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNTN3 Gene COMPARTMENTS Subcellular localization image for CNTN3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CNTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CNTN3: view

Pathways for CNTN3 Gene

SuperPathways for CNTN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with CNTN3: view

No data available for Pathways by source for CNTN3 Gene

Transcripts for CNTN3 Gene

mRNA/cDNA for CNTN3 Gene

Unigene Clusters for CNTN3 Gene

Contactin 3 (plasmacytoma associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNTN3 Gene

No ASD Table

Relevant External Links for CNTN3 Gene

GeneLoc Exon Structure for
CNTN3
ECgene alternative splicing isoforms for
CNTN3

Expression for CNTN3 Gene

mRNA expression in normal human tissues for CNTN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTN3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CNTN3 Gene

SOURCE GeneReport for Unigene cluster for CNTN3 Gene Hs.12723

mRNA Expression by UniProt/SwissProt for CNTN3 Gene

Q9P232-CNTN3_HUMAN
Tissue specificity: In brain, it is expressed in frontal lobe, occipital lobe, cerebellum and amygdala.
genes like me logo Genes that share expressions with CNTN3: view

Orthologs for CNTN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNTN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTN3 36
  • 99.29 (n)
  • 99.71 (a)
CNTN3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNTN3 36
  • 90.4 (n)
  • 92.8 (a)
CNTN3 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNTN3 36
  • 90.88 (n)
  • 93.67 (a)
CNTN3 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cntn3 36
  • 88.23 (n)
  • 91.44 (a)
Cntn3 16
Cntn3 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNTN3 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNTN3 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cntn3 36
  • 87.19 (n)
  • 90.66 (a)
chicken
(Gallus gallus)
Aves CNTN3 36
  • 76.53 (n)
  • 82.54 (a)
CNTN3 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNTN3 37
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01012080.1 37
  • 58 (a)
OneToMany
cntn3a.2 37
  • 57 (a)
OneToMany
LOC556251 36
  • 61.73 (n)
  • 59.66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta IGL1 36
  • 24.77 (n)
  • 5.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cont 36
  • 43.46 (n)
  • 34.18 (a)
Species with no ortholog for CNTN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNTN3 Gene

ENSEMBL:
Gene Tree for CNTN3 (if available)
TreeFam:
Gene Tree for CNTN3 (if available)

Paralogs for CNTN3 Gene

Selected SIMAP similar genes for CNTN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNTN3: view

Variants for CNTN3 Gene

Sequence variations from dbSNP and Humsavar for CNTN3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs471213 -- 74,352,935(+) GGTAG(A/C)CCACG intron-variant
rs473333 -- 74,334,991(+) CTAAC(A/G/T)TATAC intron-variant
rs475988 -- 74,301,846(+) TTCCA(C/T)AAATG intron-variant
rs479652 -- 74,331,415(+) cccta(C/T)gatgt intron-variant
rs480417 -- 74,331,376(+) gtgtg(C/T)agtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNTN3 Gene

Variant ID Type Subtype PubMed ID
nsv526832 CNV Gain 19592680
nsv876951 CNV Gain 21882294
nsv876954 CNV Gain 21882294
nsv834733 CNV Loss 17160897
nsv834734 CNV Loss 17160897
nsv526012 CNV Loss 19592680
esv268494 CNV Insertion 20981092
esv273937 CNV Insertion 20981092
esv2725408 CNV Deletion 23290073
esv2678039 CNV Deletion 23128226
esv273318 CNV Insertion 20981092

Relevant External Links for CNTN3 Gene

HapMap Linkage Disequilibrium report
CNTN3
Human Gene Mutation Database (HGMD)
CNTN3

Disorders for CNTN3 Gene

(1) University of Copenhagen DISEASES for CNTN3 Gene

Relevant External Links for CNTN3

Genetic Association Database (GAD)
CNTN3
Human Genome Epidemiology (HuGE) Navigator
CNTN3
genes like me logo Genes that share disorders with CNTN3: view

No data available for UniProtKB/Swiss-Prot for CNTN3 Gene

Publications for CNTN3 Gene

  1. Plasmacytoma-associated neuronal glycoprotein, Pang, maps to mouse chromosome 6 and human chromosome 3. (PMID: 8661054) Mock B.A. … Marcu K.B. (Genomics 1996) 2 3 23
  2. Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. (PMID: 11013081) Kamei Y. … Watanabe K. (Genomics 2000) 3 4 23
  3. Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. (PMID: 8586965) Yoshihara Y. … Mori K. (J. Neurobiol. 1995) 2 3
  4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for CNTN3 Gene

Sources for CNTN3 Gene

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