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CNTN3 Gene

protein-coding   GIFtS: 58
GCID: GC03M074394

Contactin 3 (Plasmacytoma Associated)


(Previous symbol: PANG)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Contactin 3 (Plasmacytoma Associated)1 2     BIG-12 3
PANG1 2 3 5     PCS2
Brain-Derived Immunoglobulin Superfamily Protein 12 3     contactin-32
Plasmacytoma-Associated Neuronal Glycoprotein2 3     KIAA14963

External Ids:    HGNC: 21731   Entrez Gene: 50672   Ensembl: ENSG000001138057   OMIM: 6013255   UniProtKB: Q9P2323   

Export aliases for CNTN3 gene to outside databases

Previous GC identifers: GC03M072881 GC03M073925 GC03M074117 GC03M074232


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CNTN3 Gene:
CNTN3 (contactin 3 (plasmacytoma associated)) is a protein-coding gene. An important paralog of this gene is CHL1.

UniProtKB/Swiss-Prot: CNTN3_HUMAN, Q9P232
Function: Contactins mediate cell surface interactions during nervous system development. Has some neurite
outgrowth-promoting activity (By similarity)

Gene Wiki entry for CNTN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNTN3 gene promoter:
         GR   STAT5B   AML1a   GR-beta   NF-E2 p45   POU2F1   POU2F1a   GR-alpha   NF-E2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNTN3 promoter sequence
   Search Chromatin IP Primers for CNTN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p12.3   Ensembl cytogenetic band:  3p12.3   HGNC cytogenetic band: 3p12.3

CNTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNTN3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M074394:  view genomic region     (about GC identifiers)

Start:
74,311,719 bp from pter      End:
74,570,343 bp from pter
Size:
258,625 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNTN3_HUMAN, Q9P232 (See protein sequence)
Recommended Name: Contactin-3 precursor  
Size: 1028 amino acids; 112883 Da
Subunit: Interacts with PTPRG
1 PDB 3D structure from and Proteopedia for CNTN3:
1WJ3 (3D)    
Secondary accessions: B9EK50 Q9H039

Explore the universe of human proteins at neXtProt for CNTN3: NX_Q9P232

Explore proteomics data for CNTN3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn65, Asn193, Asn375, Asn468, Asn489, Asn765, Asn860, Asn895, Asn913, Asn931,
                                 Asn956
  • Modification sites at PhosphoSitePlus

  • See CNTN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065923.1  
    ENSEMBL proteins: 
     ENSP00000263665  

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    antibodies-online antibodies for CNTN3 (18 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9P232

    ProtoNet protein and cluster: Q9P232

    1 Blocks protein domain: IPB013098 Immunoglobulin I-set

    UniProtKB/Swiss-Prot: CNTN3_HUMAN, Q9P232
    Similarity: Belongs to the immunoglobulin superfamily. Contactin family
    Similarity: Contains 4 fibronectin type-III domains
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with CNTN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNTN3_HUMAN, Q9P232
    Function: Contactins mediate cell surface interactions during nervous system development. Has some neurite
    outgrowth-promoting activity (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CNTN3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CNTN3

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CNTN3 (see all 39):
    hsa-miR-411* hsa-miR-379* hsa-miR-485-3p hsa-miR-10b* hsa-miR-9 hsa-miR-124 hsa-miR-34b hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidCNTN3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNTN3_HUMAN, Q9P232: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with CNTN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNTN3
    Interactions:

        Search GeneGlobe Interaction Network for CNTN3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for CNTN3 (Q9P2322, 3 ENSP000002636654) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLP1P516933, ENSP000002218914I2D: score=1 STRING: ENSP00000221891
    MSNP260383I2D: score=4 
    SMARCB1Q128243I2D: score=4 
    ATP6V0A4ENSP000002538564STRING: ENSP00000253856
    SNTG2ENSP000003118374STRING: ENSP00000311837
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007399nervous system development IEA--

    Find genes that share ontologies with CNTN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNTN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNTN3 gene: 
    NM_020872.1  

    Unigene Cluster for CNTN3:

    Contactin 3 (plasmacytoma associated)
    Hs.12723  [show with all ESTs]
    Unigene Representative Sequence: NM_020872
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263665(uc003dpm.1) ENST00000477856
    miRNA
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    hsa-miR-411* hsa-miR-379* hsa-miR-485-3p hsa-miR-10b* hsa-miR-9 hsa-miR-124 hsa-miR-34b hsa-miR-506
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    Additional mRNA sequence: 

    AB040929.1 AK001157.1 AL512746.1 BC150608.1 

    2 DOTS entries:

    DT.305364  DT.102752 

    24 AceView cDNA sequences:

    AI186035 N39078 N48433 BI757019 BI836405 BI918300 AB040929 D62792 
    AL512746 BX103598 AW152332 AU123137 BX951442 AI659681 AK001157 N50845 
    BE221817 BQ432917 BF591901 D62793 AV727219 AV731992 AV747743 AV725210 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNTN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATATGCAC
    CNTN3 Expression
    About this image


    CNTN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
    CNTN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNTN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12723

    UniProtKB/Swiss-Prot: CNTN3_HUMAN, Q9P232
    Tissue specificity: In brain, it is expressed in frontal lobe, occipital lobe, cerebellum and amygdala

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CNTN3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cntn31 , 5 contactin 31, 5 88.23(n)1
    91.44(a)1
      6 (47.52 cM)5
    184881  NM_008779.21  NP_032805.21 
     1021633065 
    chicken
    (Gallus gallus)
    Aves CNTN31 contactin 3 (plasmacytoma associated) 76.53(n)
    82.54(a)
      416101  XM_414433.4  XP_414433.4 
    lizard
    (Anolis carolinensis)
    Reptilia CNTN36
    contactin 3 (plasmacytoma associated)
    80(a)
    1 ↔ 1
    2(177945009-178219500)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5562511 contactin-3-like 61.73(n)
    59.66(a)
      556251  XM_679004.6  XP_684096.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cont1 Contactin 43.46(n)
    34.18(a)
      40553  NM_141204.4  NP_649461.2 


    ENSEMBL Gene Tree for CNTN3 (if available)
    TreeFam Gene Tree for CNTN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNTN3 gene
    CHL12  NEO12  ROBO12  CNTN52  CNTN42  IGDCC42  NRCAM2  L1CAM2  
    ROBO22  CNTN22  CNTN62  NFASC2  DCC2  PRTG2  IGDCC32  ROBO32  
    CNTN12  
    7 SIMAP similar genes for CNTN3 using alignment to 1 protein entry:     CNTN3_HUMAN:
    CNTN4    CNTN6    CNTN1    CNTN5    DKFZp781D102    CNTN2
    L1CAM

    Find genes that share paralogs with CNTN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNTN3 (see all 5298)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895552471,2
    --74315443(+) ATCCTA/GTTAAA 1 -- ds50010--------
    rs1432546411,2
    C--74315556(+) CATACC/TGCAAT 1 -- ds50010--------
    rs1161866141,2
    C,F--74315742(+) CAATCA/GTCTTG 1 -- ut311Minor allele frequency- G:0.07WA 118
    rs1822519921,2
    --74315898(+) ATATAC/GAGTAT 1 -- ut310--------
    rs1868937921,2
    --74315908(+) TATGCA/GGACCT 1 -- ut310--------
    rs1466995501,2
    C--74315954(+) TATGAC/TGACTT 1 -- ut310--------
    rs1929628211,2
    --74315962(+) CTTTAC/TCTTAA 1 -- ut310--------
    rs5163291,2
    C,F,O,A,H--74316077(+) GAAATG/ATGAAC 1 -- ut3126Minor allele frequency- A:0.49NS EA NA WA CSA 2493
    rs1851002211,2
    --74316196(+) GTCACA/GTCTTC 1 -- ut310--------
    rs1888292451,2
    --74316362(+) CCATCA/CAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CNTN3 (74311719 - 74561719 bp, first 250kb of CNTN3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CNTN3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678039CNV Deletion23128226
    esv2725408CNV Deletion23290073
    esv273318CNV Insertion20981092
    esv273937CNV Insertion20981092
    esv268494CNV Insertion20981092
    nsv526012CNV Loss19592680
    nsv834733CNV Loss17160897
    nsv834734CNV Loss17160897
    nsv876954CNV Gain21882294
    nsv876951CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601325    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CNTN3:
    Taylor's syndrome

    Find genes that share disorders with CNTN3           About GenesLikeMe

    Genetic Association Database (GAD): CNTN3
    Human Genome Epidemiology (HuGE) Navigator: CNTN3 (3 documents)

    Export disorders for CNTN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNTN3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with CNTN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Plasmacytoma-associated neuronal glycoprotein, Pang, maps to mouse chromosome 6 and human chromosome 3. (PubMed id 8661054)1, 3, 9 Mock B.A....Marcu K.B. (Genomics 1996)
    2. Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. (PubMed id 11013081)1, 2, 9 Kamei Y....Watanabe K. (Genomics 2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association. (PubMed id 19497516)1, 4 Elmore J.R....Carey D.J. (J. Vasc. Surg. 2009)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    8. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    9. Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. (PubMed id 8586965)1, 3 Yoshihara Y....Mori K. (J. Neurobiol. 1995)
    10. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5067 HGNC: 2173 AceView: CNTN3 Ensembl:ENSG00000113805 euGenes: HUgn5067
    ECgene: CNTN3 H-InvDB: CNTN3

    (According to HUGE)
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    HUGE: KIAA1496

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CNTN3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CNTN3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNTN3 gene:
    Search GeneIP for patents involving CNTN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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