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Aliases for CNTN3 Gene

Aliases for CNTN3 Gene

  • Contactin 3 (Plasmacytoma Associated) 2 3
  • PANG 3 4 6
  • Brain-Derived Immunoglobulin Superfamily Protein 1 3 4
  • Plasmacytoma-Associated Neuronal Glycoprotein 3 4
  • BIG-1 3 4
  • Contactin-3 3
  • KIAA1496 4
  • PCS 3

External Ids for CNTN3 Gene

Previous HGNC Symbols for CNTN3 Gene

  • PANG

Previous GeneCards Identifiers for CNTN3 Gene

  • GC03M072881
  • GC03M073925
  • GC03M074117
  • GC03M074394

Summaries for CNTN3 Gene

GeneCards Summary for CNTN3 Gene

CNTN3 (Contactin 3 (Plasmacytoma Associated)) is a Protein Coding gene. An important paralog of this gene is PRTG.

UniProtKB/Swiss-Prot for CNTN3 Gene

  • Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).

Gene Wiki entry for CNTN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTN3 Gene

Genomics for CNTN3 Gene

Regulatory Elements for CNTN3 Gene

Genomic Location for CNTN3 Gene

74,262,568 bp from pter
74,614,436 bp from pter
351,869 bases
Minus strand

Genomic View for CNTN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTN3 Gene

Proteins for CNTN3 Gene

  • Protein details for CNTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B9EK50
    • Q9H039

    Protein attributes for CNTN3 Gene

    1028 amino acids
    Molecular mass:
    112883 Da
    Quaternary structure:
    • Interacts with PTPRG.

    Three dimensional structures from OCA and Proteopedia for CNTN3 Gene

neXtProt entry for CNTN3 Gene

Proteomics data for CNTN3 Gene at MOPED

Post-translational modifications for CNTN3 Gene

  • Glycosylation at Asn65, Asn193, Asn375, Asn468, Asn489, Asn765, Asn860, Asn895, Asn913, Asn931, and Asn956
  • Modification sites at PhosphoSitePlus

Other Protein References for CNTN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNTN3 Gene

Domains for CNTN3 Gene

Gene Families for CNTN3 Gene

  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Protein Domains for CNTN3 Gene

Suggested Antigen Peptide Sequences for CNTN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9P232
  • Contains 4 fibronectin type-III domains.
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. Contactin family.
genes like me logo Genes that share domains with CNTN3: view

Function for CNTN3 Gene

Molecular function for CNTN3 Gene

UniProtKB/Swiss-Prot Function: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).

Gene Ontology (GO) - Molecular Function for CNTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CNTN3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNTN3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CNTN3 Gene

Localization for CNTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTN3 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for CNTN3 Gene COMPARTMENTS Subcellular localization image for CNTN3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CNTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CNTN3: view

Pathways for CNTN3 Gene

SuperPathways for CNTN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with CNTN3: view

No data available for Pathways by source for CNTN3 Gene

Transcripts for CNTN3 Gene

mRNA/cDNA for CNTN3 Gene

Unigene Clusters for CNTN3 Gene

Contactin 3 (plasmacytoma associated):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNTN3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CNTN3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTN3 Gene

No ASD Table

Relevant External Links for CNTN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNTN3 Gene

mRNA expression in normal human tissues for CNTN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTN3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CNTN3 Gene

SOURCE GeneReport for Unigene cluster for CNTN3 Gene Hs.12723

mRNA Expression by UniProt/SwissProt for CNTN3 Gene

Tissue specificity: In brain, it is expressed in frontal lobe, occipital lobe, cerebellum and amygdala.
genes like me logo Genes that share expressions with CNTN3: view

In Situ Assay Products

Orthologs for CNTN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNTN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNTN3 35
  • 99.29 (n)
  • 99.71 (a)
CNTN3 36
  • 100 (a)
(Bos Taurus)
Mammalia CNTN3 35
  • 90.4 (n)
  • 92.8 (a)
CNTN3 36
  • 93 (a)
(Canis familiaris)
Mammalia CNTN3 35
  • 90.88 (n)
  • 93.67 (a)
CNTN3 36
  • 94 (a)
(Mus musculus)
Mammalia Cntn3 35
  • 88.23 (n)
  • 91.44 (a)
Cntn3 16
Cntn3 36
  • 91 (a)
(Monodelphis domestica)
Mammalia CNTN3 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia CNTN3 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Cntn3 35
  • 87.19 (n)
  • 90.66 (a)
(Gallus gallus)
Aves CNTN3 35
  • 76.53 (n)
  • 82.54 (a)
CNTN3 36
  • 81 (a)
(Anolis carolinensis)
Reptilia CNTN3 36
  • 80 (a)
(Danio rerio)
Actinopterygii CABZ01012080.1 36
  • 58 (a)
cntn3a.2 36
  • 57 (a)
LOC556251 35
  • 61.73 (n)
  • 59.66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta IGL1 35
  • 24.77 (n)
  • 5.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cont 35
  • 43.46 (n)
  • 34.18 (a)
Species with no ortholog for CNTN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNTN3 Gene

Gene Tree for CNTN3 (if available)
Gene Tree for CNTN3 (if available)

Paralogs for CNTN3 Gene

Selected SIMAP similar genes for CNTN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNTN3: view

Variants for CNTN3 Gene

Sequence variations from dbSNP and Humsavar for CNTN3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs471213 -- 74,352,935(+) GGTAG(A/C)CCACG intron-variant
rs473333 -- 74,334,991(+) CTAAC(A/G/T)TATAC intron-variant
rs475988 -- 74,301,846(+) TTCCA(C/T)AAATG intron-variant
rs479652 -- 74,331,415(+) cccta(C/T)gatgt intron-variant
rs480417 -- 74,331,376(+) gtgtg(C/T)agtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNTN3 Gene

Variant ID Type Subtype PubMed ID
nsv526832 CNV Gain 19592680
nsv876951 CNV Gain 21882294
nsv876954 CNV Gain 21882294
nsv834733 CNV Loss 17160897
nsv834734 CNV Loss 17160897
nsv526012 CNV Loss 19592680
esv268494 CNV Insertion 20981092
esv273937 CNV Insertion 20981092
esv2725408 CNV Deletion 23290073
esv2678039 CNV Deletion 23128226
esv273318 CNV Insertion 20981092

Relevant External Links for CNTN3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTN3 Gene

Disorders for CNTN3 Gene

(1) University of Copenhagen DISEASES for CNTN3 Gene

Relevant External Links for CNTN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CNTN3: view

No data available for UniProtKB/Swiss-Prot for CNTN3 Gene

Publications for CNTN3 Gene

  1. Plasmacytoma-associated neuronal glycoprotein, Pang, maps to mouse chromosome 6 and human chromosome 3. (PMID: 8661054) Mock B.A. … Marcu K.B. (Genomics 1996) 2 3 23
  2. Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. (PMID: 11013081) Kamei Y. … Watanabe K. (Genomics 2000) 3 4 23
  3. Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. (PMID: 8586965) Yoshihara Y. … Mori K. (J. Neurobiol. 1995) 2 3
  4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for CNTN3 Gene

Sources for CNTN3 Gene

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