Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CNTN2 Gene

protein-coding GIFtS: 65
GCID: GC01P205012

contactin 2 (axonal)

(Previous symbols: TAX, AXT)

Explore 40 diseases affiliated with
CNTN2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Contactin 2 (Axonal)¹ ²		TAX-1² ³
TAX1¹ ² ³ ⁵		Axonin-1 Cell Adhesion Molecule²
AXT¹ ² ³		Contactin 2 (Transiently Expressed)²
TAX¹ ² ⁵		Contactin-2¹
TAG-1¹ ²		Transiently-Expressed Axonal Glycoprotein²
Axonal Glycoprotein TAG-1² ³		Axonin-1³
Transient Axonal Glycoprotein 1² ³		TAG1³

External Ids:	HGNC: 2172¹	Entrez Gene: 6900²	Ensembl: ENSG00000184144⁷	OMIM: 190197⁵	UniProtKB: Q02246³

Export aliases for CNTN2 gene to outside databases

Previous GC identifers: GC01P202738 GC01P200473 GC01P201372 GC01P202189 GC01P201743 GC01P203278 GC01P176177

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNTN2:

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol

(GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the

formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may

provide a potential target for therapeutic intervention. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CNTN2_HUMAN, Q02246

Function: May play a role in the initial growth and guidance of axons. May be involved in cell adhesion

Gene Wiki entry for CNTN2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CNTN2 gene promoter:
AP-1 AML1a ATF-2 NRSF form 1 c-Jun NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNTN2 promoter sequence

Search SABiosciences Chromatin IP Primers for CNTN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

CNTN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNTN2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P205012: view genomic region (about GC identifiers)

Start:	205,012,325 bp from pter	End:	205,047,627 bp from pter
Size:	35,303 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNTN2_HUMAN, Q02246 (See protein sequence)

Recommended Name: Contactin-2 precursor

Size: 1040 amino acids; 113393 Da

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor

and is also released from neurons

1 PDB 3D structure from and Proteopedia for CNTN2:

2OM5 (3D)

Secondary accessions: P78432 Q5T054

Explore the universe of human proteins at neXtProt for CNTN2: NX_Q02246

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q02246

CNTN2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005067.1

ENSEMBL proteins:

ENSP00000330633

Reactome Protein details: Q02246
Human Recombinant Protein Products for CNTN2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CNTN2 (Contactin-2/TAG1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CNTN2 OriGene Custom Protein Services for CNTN2
	GenScript Custom Purified and Recombinant Proteins Services for CNTN2
	Novus Biologicals CNTN2 Protein Novus Biologicals CNTN2 Lysate
	Sino Biological Recombinant Protein for CNTN2
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CNTN2

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	ISS	--
GO:0005887	integral to plasma membrane	TAS	8425542
GO:0008076	voltage-gated potassium channel complex	IEA	--
GO:0009986	cell surface	IEA	--
GO:0030424	axon	--	--

CNTN2 for ontologies About GeneDecksing

CNTN2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CNTN2 (Contactin-2/TAG1)
	OriGene Antibodies: CNTN2 OriGene Custom Antibody Services for CNTN2
	GenScript Custom Superior Antibodies Services for CNTN2
	Novus Biologicals CNTN2 Antibodies
	Abcam antibodies for CNTN2
	Uscn Antibodies for CNTN2
	ThermoFisher Antibodies for CNTN2

Assay Products for CNTN2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CNTN2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CNTN2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CNTN2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003598 Ig_sub2

IPR003961 Fibronectin_type3

IPR013098 Ig_I-set

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q02246

ProtoNet protein and cluster: Q02246

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB003962 Fibronectin type III repeat signature

UniProtKB/Swiss-Prot: CNTN2_HUMAN, Q02246

Similarity: Belongs to the immunoglobulin superfamily. Contactin family

Similarity: Contains 4 fibronectin type-III domains

Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CNTN2_HUMAN, Q02246

Function: May play a role in the initial growth and guidance of axons. May be involved in cell adhesion

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001948	glycoprotein binding	IEA	--
GO:0005515	protein binding	--	--
GO:0030246	carbohydrate binding	IEA	--
GO:0042802	identical protein binding	TAS	12963709
GO:0043621	protein self-association	IEA	--

CNTN2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CNTN2:

Increased gamma-H2AX phosphory

2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cntn2):

behavior/neurological

nervous system

CNTN2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CNTN2: Cntn2^tm2Furl Cntn2^tm1Fuka

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CNTN2

miRNA Products:		OriGene 3'-UTR Clone: CNTN2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNTN2
		8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate CNTN2 (see all 50):
		hsa-miR-765 hsa-miR-128 hsa-miR-3653 hsa-miR-30d hsa-miR-449a hsa-miR-30a hsa-miR-3658 hsa-miR-155*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNTN2 (see all 7) OriGene shRNA RFP: CNTN2 OriGene siRNA: CNTN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNTN2
		Sirion Biotech Custom design and validation of potent shRNA sequences against CNTN2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CNTN2
			Sirion Biotech Customized adenovirus for overexpression of CNTN2 Sirion Biotech Customized adenovirus for potent knockdown of CNTN2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTN2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTN2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CNTN2 (NM_005076)
		Sino Biological Human cDNA Clone for CNTN2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNTN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTN2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CNTN2
		Search LifeMap BioReagents cell lines for CNTN2
		Sirion Biotech Customized stable knockdown cell line services for CNTN2 Sirion Biotech Customized inducible knockdown cell line services for CNTN2 Sirion Biotech Customized stable overexpressing cell line services for CNTN2 Sirion Biotech Customized inducible overexpressing cell line services for CNTN2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTN2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69

NCAM signaling for neurite out-growth

NCAM signaling for neurite out-growth

1.00

NCAM1 interactions

0.62

NrCAM interactions

NrCAM interactions

1.00

Cell adhesion molecules (CAMs)

Cell adhesion molecules (CAMs)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for CNTN2 (see all 6)

	L1CAM interactions
	Developmental Biology
	NCAM1 interactions
	NrCAM interactions
	NCAM signaling for neurite out-growth

1 Kegg Pathway (Kegg details for CNTN2):

Cell adhesion molecules (CAMs)

CNTN2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CNTN2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for CNTN2 (Q02246^{2, 3} ENSP00000330633⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP3K7	O43318²^,³, ENSP00000358335⁴	MINT-4652670 I2D: score=1 STRING: ENSP00000358335
CNTN1	Q12860³, ENSP00000325660⁴	I2D: score=3 STRING: ENSP00000325660
NFYB	P25208³, ENSP00000240055⁴	I2D: score=3 STRING: ENSP00000240055
CDK2	P24941³, ENSP00000266970⁴	I2D: score=1 STRING: ENSP00000266970
CHUK	O15111³, ENSP00000359424⁴	I2D: score=1 STRING: ENSP00000359424

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	IEA	--
GO:0001764	neuron migration	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0007160	cell-matrix adhesion	--	--
GO:0007409	axonogenesis	--	--

CNTN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CNTN2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CNTN2
10/44 Novoseek chemical compound relationships for CNTN2 gene (see all 44) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclic amp	51.7	18	16920823 (2), 8679308 (1), 10702386 (1), 10233947 (1) (see all 15)
chloramphenicol	36.9	11	2293664 (2), 7579405 (1), 9052856 (1), 1768653 (1) (see all 10)
neurocan	35.8	5	8663515 (3), 11766883 (1)
leucine	34.8	14	7666522 (2), 8628284 (2), 10906125 (1), 9190894 (1) (see all 10)
ionomycin	18.8	10	8662878 (1), 17145747 (1), 9190210 (1), 10381170 (1) (see all 6)
alpha-amanitin	18.4	1	7609077 (1)
leptomycin b	17.6	3	12670929 (2)
n-(4-hydroxyphenyl)retinamide	17.5	1	14712289 (1)
lysine	15.3	10	15479824 (2), 17145747 (1), 19200568 (1), 18081936 (1)
camptothecin	13.1	3	15367606 (1), 10792988 (1)

Search CenterWatch for drugs/clinical trials and news about CNTN2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CNTN2 gene:

NM_005076.3

Unigene Cluster for CNTN2:

Contactin 2 (axonal)

Hs.519220 [show with all ESTs]

Unigene Representative Sequence: NM_005076

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000331830(uc001hbq.1 uc001hbr.3 uc001hbs.3) ENST00000532366

ENST00000530117(uc009xbi.3) ENST00000481872 ENST00000527340 ENST00000530594

ENST00000525433

miRNA Products:		OriGene 3'-UTR Clone: CNTN2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNTN2
		8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate CNTN2 (see all 50):
		hsa-miR-765 hsa-miR-128 hsa-miR-3653 hsa-miR-30d hsa-miR-449a hsa-miR-30a hsa-miR-3658 hsa-miR-155*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNTN2 (see all 7) OriGene shRNA RFP: CNTN2 OriGene siRNA: CNTN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNTN2
		Sirion Biotech Custom design and validation of potent shRNA sequences against CNTN2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTN2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTN2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CNTN2 (NM_005076)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNTN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTN2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNTN2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CNTN2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNTN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTN2

Additional cDNA sequence:

AB074271.1 AK095531.1 AK289985.1 BC036477.2 BC129986.1 CR749495.1 X67734.1 X68274.1

9 DOTS entries:

DT.100018504 DT.40269094 DT.102824485 DT.310947 DT.121330376 DT.121330281 DT.121330312 DT.121330372

DT.121330408

24/65 AceView cDNA sequences (see all 65):

CB155420 X67734 BM673097 NM_005076 BM704492 X68274 AL120536 BX645368

CD242651 BP349343 BM709315 AL133877 AA330218 AI565531 H18697 AI366526

BU732462 BM807770 T08814 BP349295 AK095531 BC036477 BF740264 BI913998

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CNTN2 (see all 8) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15	^
SP1:					-						-		-																-
SP2:																													-
SP3:
SP4:																													-				-		-		-		-		-		-
SP5:

ExUns:	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20	^	21	^	22a	·	22b	^	23	^	24
SP1:
SP2:
SP3:							-		-
SP4:
SP5:							-

ECgene alternative splicing isoforms for CNTN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CNTN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAACAGGCA

About this image

CNTN2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Brain

Brain

Brain

Eye

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CNTN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNTN2

SOURCE GeneReport for Unigene cluster: Hs.519220

SABiosciences Custom PCR Arrays for CNTN2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNTN2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CNTN2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNTN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTN2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CNTN2 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CNTN2¹	contactin 2 (axonal)	74.09(n) 75.29(a)		419825 NM_001004395.1 NP_001004395.1
lizard (Anolis carolinensis)	Reptilia	CNTN2⁶ --	--	71(a) 36(a)	1 ↔ 1 possible ortholog	4(116352769-116382317) AAWZ02038983(1406-5953)
zebrafish (Danio rerio)	Actinopterygii	cntn2²	contactin 2	75.94(n)		30726 AF064799.1
fruit fly (Drosophila melanogaster)	Insecta	Cont³	cell adhesion	31(a)		82A6 --
worm (Caenorhabditis elegans)	Secernentea	C33F10.5a³	fibronectin, IG-like domains of NCAM	25(a) (best of 2)		II(4798268-4805531) --

ENSEMBL Gene Tree for CNTN2 (if available)
TreeFam Gene Tree for CNTN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CNTN2 gene

CHL1² DSCAM² CNTN6² CNTN5² CNTN4² NFASC² NRCAM² CNTN3²

SDK2² SDK1² DSCAML1² L1CAM² CNTN1²

11 SIMAP similar genes for CNTN2 using alignment to 3 protein entries: CNTN2_HUMAN (see all proteins):

DKFZp781D102 MUSK CNTN4 CNTN3 CNTN1 CNTN5

CNTN6 HSPG2 CHL1 L1CAM NRCAM

CNTN2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191852868^1,2		--	205010374(+)	`CATTGA/TGATCT`	1	--	us2k¹		0	--	--	--	--
rs112730978^1,2	C	--	205010380(+)	`GATCTGA/-GAGTC`	1	--	us2k¹		1		CSA	2
rs3753846^1,2	H	--	205010467(+)	`AAATAG/AAGTCA`	1	--	us2k¹		4		NS EA	414
rs116489364^1,2		--	205010490(+)	`TCTCCG/ATCTAA`	1	--	us2k¹		1		NA	120
rs184023317^1,2		--	205010633(+)	`AACTTA/GCAGAG`	1	--	us2k¹		0	--	--	--	--
rs186480157^1,2		--	205010686(+)	`CAAGGC/TTCACC`	1	--	us2k¹		0	--	--	--	--
rs191378734^1,2		--	205010765(+)	`AGGAAA/GGGAAA`	1	--	us2k¹		0	--	--	--	--
rs7513016^1,2	C,H	--	205010923(+)	`AGGAAG/AGGAGG`	1	--	us2k¹ trp³		9		WA NA CSA EA	369
rs7523345^1,2	C,A	--	205010925(+)	`GAAAGG/CAGGGG`	1	--	us2k¹ trp³		1		WA	2
rs78010158^1,2		--	205011023(+)	`CATTCT/CGGCCC`	1	--	us2k¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for CNTN2 (205012325 - 205047627 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CNTN2
1 CNV: 39029

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNTN2

DNA2.0 Custom Variant and Variant Library Synthesis for CNTN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CNTN2 for disorders           About GeneDecksing

OMIM gene information: 190197    OMIM disorders: --

20/40 diseases for CNTN2 (see all 40):    About MalaCards

htlv-1 associated myelopathy van der woude syndrome human t-cell leukemia virus type 1 human t-cell leukemia virus type 2

spinal cord disease tropical spastic paraparesis dna topoisomerase i large granular lymphocyte leukemia

spastic paraparesis demyelinating polyneuropathy herpes simplex leukemia/lymphoma

urinary bladder cancer t-cell leukemia neurofibroma spasticity

adult t-cell leukemia polymyositis transitional cell carcinoma rheumatoid arthritis

4 diseases from the University of Copenhagen DISEASES database for CNTN2:

Adult T-cell leukemia Tropical spastic paraparesis Urinary bladder cancer Transitional cell carcinoma

10/31 Novoseek disease relationships for CNTN2 gene (see all 31) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia t-cell	98.1	158	8346248 (3), 2293664 (3), 9733879 (2), 8420985 (2) (see all 99)
paraparesis tropical spastic	90.2	3	1540409 (1), 11964301 (1), 8648737 (1)
myelopathy, htlv-1-associated	85.7	3	11964301 (1), 15479824 (1), 11559817 (1)
htlv-i infections	85.4	10	18840303 (1), 12660926 (1), 8699061 (1), 9389355 (1) (see all 8)
leukemogenesis	80.4	27	8152309 (1), 11024116 (1), 11264182 (1), 18518755 (1) (see all 25)
t cell leukemia lymphoma adult	75.1	1	1501887 (1)
htlv infections	73.8	2	9226179 (1), 9359663 (1)
leukemia bovine	65.8	1	10359545 (1)
leukemia	56.5	16	14533803 (1), 17707401 (1), 19701248 (1), 7862633 (1) (see all 13)
leukemia lymphocytic large granular	49.5	1	7862633 (1)

Human Genome Epidemiology (HuGE) Navigator: CNTN2 (2 documents)

Export disorders for CNTN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CNTN2 gene, integrated from 9 sources (see all 449):
(articles sorted by number of sources associating them with CNTN2)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1. (PubMed id 8307567)^{1, 2, 3, 9} Tsiotra C.P.... Papamatheakis J. (1993)
cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1. (PubMed id 8425542)^{1, 2, 9} Hasler T.H.... Sonderegger P. (1993)
The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction. (PubMed id 17766378)^{1, 2} Mortl M.... Welte W. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. (PubMed id 8586965)^{1, 3} Yoshihara Y....Mori K. (1995)
The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter. (PubMed id 8586412)^{1, 2} Kozlov S.V....Sonderegger P. (1995)
SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR. (PubMed id 16409643)^{1, 9} Kamoi K.... Watanabe T. (2006)
Cell-cell adhesion by homophilic interaction of the neuronal recognition molecule axonin-1. (PubMed id 8344273)^{1, 9} Rader C....Sonderegger P. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6900	HGNC: 2172	AceView: CNTN2	Ensembl:ENSG00000184144	euGenes: HUgn6900
ECgene: CNTN2	Kegg: 6900	H-InvDB: CNTN2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CNTN2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CNTN2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CNTN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CNTN2 gene:
Search GeneIP for patents involving CNTN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CNTN2 (Contactin-2/TAG1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for CNTN2 (Contactin-2/TAG1)

	OriGene Antibodies for CNTN2		OriGene shRNA RFP for CNTN2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNTN2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNTN2
	OriGene Protein Over-expression Lysate for CNTN2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CNTN2		OriGene 3'-UTR Clone for CNTN2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTN2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTN2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CNTN2		OriGene Custom Protein Services for CNTN2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNTN2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNTN2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTN2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNTN2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTN2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNTN2

	GenScript Custom Purified and Recombinant Proteins Services for CNTN2		GenScript cDNA clones with any tag delivered in your preferred vector for CNTN2
	GenScript Custom Assay Services for CNTN2		GenScript Custom Superior Antibodies Services for CNTN2
	GenScript Custom overexpressing Cell Line Services for CNTN2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CNTN2 promoter
	Search Chromatin IP Primers for CNTN2
	RT² qPCR Primer Assay in human, mouse, rat CNTN2
	GNC Network for CNTN2
	SABiosciences Custom PCR Arrays for CNTN2

Search Tocris compounds for CNTN2

	Proteins and Antibodies for CNTN2
	cDNA Clones for CNTN2
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CNTN2 antibodies
	CNTN2 proteins
	CNTN2 lysates

	Antibodies for CNTN2
	See all of Abcam's Antibodies, Kits and Proteins for CNTN2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CNTN2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CNTN2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTN2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for CNTN2
	SwitchGear Promoter luciferase reporter plasmids for CNTN2

ThermoFisher Antibodies for CNTN2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTN2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CNTN2

Sirion Biotech Customized:

	stable knockdown cell line services for CNTN2
	inducible knockdown cell line services for CNTN2
	design and validation of potent shRNA sequences against CNTN2
	adenovirus for potent knockdown of CNTN2
	adenovirus for overexpression of CNTN2
	stable overexpressing cell line services for CNTN2
	inducible overexpressing cell line services for CNTN2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CNTN2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CNTN2 Gene

contactin 2 (axonal)

Aliases
for CNTN2 gene

Summaries
for CNTN2 gene

Genomic Views
for CNTN2 gene

Proteins
for CNTN2 gene

Protein Domains /
Families
for CNTN2 gene

Function
for CNTN2 gene

Pathways & Interactions
for CNTN2 gene

Drugs & Compounds
for CNTN2 gene

Transcripts
for CNTN2 gene

Expression
for CNTN2 gene

Orthologs
for CNTN2 gene

Paralogs
for CNTN2 gene

Genomic Variants
for CNTN2 gene

Disorders / Diseases
for CNTN2 gene

Publications
for CNTN2 gene

External Searches for CNTN2 gene

Genome Databases showing CNTN2 gene

Other Databases showing CNTN2 gene

Specialized Databases showing CNTN2 gene

Intellectual Property
for CNTN2 gene

Products
for CNTN2 gene

View Random Gene

Lymphoma
Leukemia Lymphocytic Large Granular
Neurodegenerative Diseases
Leukemia T-Cell
Neurological Disorders
Herpes Simplex
Inflammation
Lymphoproliferative Disorders
HTLV-I Infections
MYELOPATHY, HTLV-1-ASSOCIATED
T Cell Leukemia Lymphoma Adult
Carcinoma
solid tumor
immunodeficiency
Paraparesis Tropical Spastic
Leukemia
Teratocarcinoma
HTLV Infections
MYELOMA
Rheumatoid Arthritis
neoplastic disease
Carrier State
Tumors
Leukemia Bovine
primary tumor
Neurofibroma
Necrosis
leukemogenesis
Cancer
virus infection
Polymyositis

Advanced Search

Export list of displayed genes

CNTN2 Gene

contactin 2 (axonal)

Aliasesfor CNTN2 gene

Summariesfor CNTN2 gene

Genomic Viewsfor CNTN2 gene

Proteinsfor CNTN2 gene

Protein Domains /Familiesfor CNTN2 gene

Functionfor CNTN2 gene

Pathways & Interactionsfor CNTN2 gene

Drugs & Compoundsfor CNTN2 gene

Transcriptsfor CNTN2 gene

Expression for CNTN2 gene

Orthologsfor CNTN2 gene

Paralogsfor CNTN2 gene

Genomic Variantsfor CNTN2 gene

Disorders / Diseasesfor CNTN2 gene

Publicationsfor CNTN2 gene

External Searches for CNTN2 gene

Genome Databases showing CNTN2 gene

Other Databases showing CNTN2 gene

Specialized Databases showing CNTN2 gene

Intellectual Propertyfor CNTN2 gene

Productsfor CNTN2 gene

View Random Gene

Aliases
for CNTN2 gene

Summaries
for CNTN2 gene

Genomic Views
for CNTN2 gene

Proteins
for CNTN2 gene

Protein Domains /
Families
for CNTN2 gene

Function
for CNTN2 gene

Pathways & Interactions
for CNTN2 gene

Drugs & Compounds
for CNTN2 gene

Transcripts
for CNTN2 gene

Expression
for CNTN2 gene

Orthologs
for CNTN2 gene

Paralogs
for CNTN2 gene

Genomic Variants
for CNTN2 gene

Disorders / Diseases
for CNTN2 gene

Publications
for CNTN2 gene

Intellectual Property
for CNTN2 gene

Products
for CNTN2 gene