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Aliases for CNTN2 Gene

Aliases for CNTN2 Gene

  • Contactin 2 (Axonal) 2 3
  • TAX1 3 4 6
  • Transient Axonal Glycoprotein 1 3 4
  • Axonal Glycoprotein TAG-1 3 4
  • FAME5 3 6
  • AXT 3 4
  • TAX 3 6
  • Transiently-Expressed Axonal Glycoprotein 3
  • Contactin 2 (Transiently Expressed) 3
  • Axonin-1 Cell Adhesion Molecule 3
  • Contactin-2 3
  • Axonin-1 4
  • TAG-1 3
  • TAX-1 4
  • TAG1 4

External Ids for CNTN2 Gene

Previous HGNC Symbols for CNTN2 Gene

  • TAX
  • AXT

Previous GeneCards Identifiers for CNTN2 Gene

  • GC01P202738
  • GC01P200473
  • GC01P201372
  • GC01P202189
  • GC01P201743
  • GC01P203278
  • GC01P205012
  • GC01P176177

Summaries for CNTN2 Gene

Entrez Gene Summary for CNTN2 Gene

  • The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNTN2 Gene

CNTN2 (Contactin 2 (Axonal)) is a Protein Coding gene. Diseases associated with CNTN2 include epilepsy, familial adult myoclonic, 5 and benign adult familial myoclonic epilepsy. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include identical protein binding and glycoprotein binding. An important paralog of this gene is PRTG.

UniProtKB/Swiss-Prot for CNTN2 Gene

  • In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.

Gene Wiki entry for CNTN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTN2 Gene

Genomics for CNTN2 Gene

Regulatory Elements for CNTN2 Gene

Genomic Location for CNTN2 Gene

Start:
205,043,197 bp from pter
End:
205,078,499 bp from pter
Size:
35,303 bases
Orientation:
Plus strand

Genomic View for CNTN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNTN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTN2 Gene

Proteins for CNTN2 Gene

  • Protein details for CNTN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02246-CNTN2_HUMAN
    Recommended name:
    Contactin-2
    Protein Accession:
    Q02246
    Secondary Accessions:
    • P78432
    • Q5T054

    Protein attributes for CNTN2 Gene

    Size:
    1040 amino acids
    Molecular mass:
    113393 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CNTN2 Gene

neXtProt entry for CNTN2 Gene

Proteomics data for CNTN2 Gene at MOPED

Post-translational modifications for CNTN2 Gene

  • Glycosylation at Asn76, Asn198, Asn204, Asn461, Asn477, Asn498, Asn525, Asn830, Asn904, Asn918, and Asn940
  • Modification sites at PhosphoSitePlus

Other Protein References for CNTN2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CNTN2 (Contactin-2/TAG1)

No data available for DME Specific Peptides for CNTN2 Gene

Domains for CNTN2 Gene

Gene Families for CNTN2 Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Suggested Antigen Peptide Sequences for CNTN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q02246

UniProtKB/Swiss-Prot:

CNTN2_HUMAN :
  • Q02246
Domain:
  • Contains 4 fibronectin type-III domains.
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. Contactin family.
genes like me logo Genes that share domains with CNTN2: view

Function for CNTN2 Gene

Molecular function for CNTN2 Gene

UniProtKB/Swiss-Prot Function: In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.

Gene Ontology (GO) - Molecular Function for CNTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IEA --
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
GO:0042802 identical protein binding TAS 12963709
GO:0043621 protein self-association IEA --
genes like me logo Genes that share ontologies with CNTN2: view

Phenotypes for CNTN2 Gene

genes like me logo Genes that share phenotypes with CNTN2: view

Animal Models for CNTN2 Gene

MGI Knock Outs for CNTN2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNTN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CNTN2 Gene

Localization for CNTN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTN2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNTN2 Gene COMPARTMENTS Subcellular localization image for CNTN2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CNTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane TAS 8425542
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0009986 cell surface IEA --
GO:0030424 axon --
genes like me logo Genes that share ontologies with CNTN2: view

Pathways for CNTN2 Gene

genes like me logo Genes that share pathways with CNTN2: view

Pathways by source for CNTN2 Gene

Gene Ontology (GO) - Biological Process for CNTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0001764 neuron migration --
GO:0007155 cell adhesion IEA --
GO:0007411 axon guidance TAS --
GO:0007413 axonal fasciculation IEA --
genes like me logo Genes that share ontologies with CNTN2: view

Compounds for CNTN2 Gene

(44) Novoseek inferred chemical compound relationships for CNTN2 Gene

Compound -log(P) Hits PubMed IDs
cyclic amp 51.7 16
chloramphenicol 36.9 11
neurocan 35.8 4
leucine 34.8 12
ionomycin 18.8 6
genes like me logo Genes that share compounds with CNTN2: view

Transcripts for CNTN2 Gene

Unigene Clusters for CNTN2 Gene

Contactin 2 (axonal):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNTN2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CNTN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTN2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^
SP1: - - - -
SP2: -
SP3:
SP4: - - - - - - -
SP5:
SP6:
SP7:
SP8:

ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
SP1:
SP2:
SP3: - -
SP4:
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for CNTN2 Gene

GeneLoc Exon Structure for
CNTN2
ECgene alternative splicing isoforms for
CNTN2

Expression for CNTN2 Gene

mRNA expression in normal human tissues for CNTN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTN2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (11.6), Brain - Substantia nigra (7.6), and Brain - Hippocampus (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CNTN2 Gene

SOURCE GeneReport for Unigene cluster for CNTN2 Gene Hs.519220

genes like me logo Genes that share expressions with CNTN2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CNTN2 Gene

Orthologs for CNTN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNTN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTN2 35
  • 98.71 (n)
  • 98.5 (a)
CNTN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNTN2 35
  • 88.72 (n)
  • 91.25 (a)
CNTN2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNTN2 35
  • 90.42 (n)
  • 92.49 (a)
CNTN2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cntn2 35
  • 86.42 (n)
  • 91.72 (a)
Cntn2 16
Cntn2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNTN2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNTN2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cntn2 35
  • 86.85 (n)
  • 91.62 (a)
chicken
(Gallus gallus)
Aves CNTN2 35
  • 74.51 (n)
  • 76.08 (a)
CNTN2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNTN2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487049 35
  • 63.57 (n)
  • 64.74 (a)
zebrafish
(Danio rerio)
Actinopterygii cntn2 35
  • 62.44 (n)
  • 60.59 (a)
cntn2 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cont 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea C33F10.5a 37
  • 25 (a)
C33F10.5b 37
  • 25 (a)
Species with no ortholog for CNTN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNTN2 Gene

ENSEMBL:
Gene Tree for CNTN2 (if available)
TreeFam:
Gene Tree for CNTN2 (if available)

Paralogs for CNTN2 Gene

Selected SIMAP similar genes for CNTN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CNTN2: view

Variants for CNTN2 Gene

Sequence variations from dbSNP and Humsavar for CNTN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs16937 -- 205,066,327(+) ACTGC(A/G)TCCTC intron-variant
rs867513 -- 205,048,834(+) AAATG(A/G)ATGCA intron-variant
rs871423 -- 205,059,846(+) CAGTA(A/C)CTCTC intron-variant
rs872379 -- 205,059,311(-) AGCCA(A/C)GCCTG intron-variant
rs885857 -- 205,057,231(+) agaag(A/C)gttct intron-variant

Relevant External Links for CNTN2 Gene

HapMap Linkage Disequilibrium report
CNTN2
Human Gene Mutation Database (HGMD)
CNTN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CNTN2 Gene

Disorders for CNTN2 Gene

(1) OMIM Diseases for CNTN2 Gene (190197)

UniProtKB/Swiss-Prot

CNTN2_HUMAN
  • Epilepsy, familial adult myoclonic, 5 (FAME5) [MIM:615400]: A form of cortical myoclonic tremor with epilepsy, a syndrome characterized by cortical myoclonus and variable occurrence of epileptic seizures. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom; both complex partial as well as generalized tonic clonic seizures are described. Some patients exhibit mild cognitive impairment. {ECO:0000269 PubMed:23518707}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(31) Novoseek inferred disease relationships for CNTN2 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 98.1 113
paraparesis tropical spastic 90.2 3
myelopathy, htlv-1-associated 85.7 3
htlv-i infections 85.4 8
leukemogenesis 80.4 25

Relevant External Links for CNTN2

Genetic Association Database (GAD)
CNTN2
Human Genome Epidemiology (HuGE) Navigator
CNTN2
genes like me logo Genes that share disorders with CNTN2: view

Publications for CNTN2 Gene

  1. Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1. (PMID: 8307567) Tsiotra C.P. … Papamatheakis J. (Genomics 1993) 2 3 4 23
  2. cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1. (PMID: 8425542) Hasler T.H. … Sonderegger P. (Eur. J. Biochem. 1993) 3 4 23
  3. Cell-cell adhesion by homophilic interaction of the neuronal recognition molecule axonin-1. (PMID: 8344273) Rader C. … Sonderegger P. (Eur. J. Biochem. 1993) 3 23
  4. Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach. (PMID: 16822311) de la Fuente C. … Kashanchi F. (Retrovirology 2006) 3 23
  5. Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesion. (PMID: 9837910) Malhotra J.D. … Hortsch M. (J. Biol. Chem. 1998) 3 23

Products for CNTN2 Gene

Sources for CNTN2 Gene

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