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Aliases for CNTLN Gene

Aliases for CNTLN Gene

  • Centlein, Centrosomal Protein 2 3
  • Centrosomal Protein 3 4
  • C9orf101 3 4
  • C9orf39 3 4
  • Chromosome 9 Open Reading Frame 101 2
  • Chromosome 9 Open Reading Frame 39 2
  • BA340N12.1 3

External Ids for CNTLN Gene

Previous HGNC Symbols for CNTLN Gene

  • C9orf101
  • C9orf39

Summaries for CNTLN Gene

GeneCards Summary for CNTLN Gene

CNTLN (Centlein, Centrosomal Protein) is a Protein Coding gene. Diseases associated with CNTLN include seckel syndrome and joubert syndrome 1. GO annotations related to this gene include protein kinase binding and protein binding, bridging.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTLN Gene

Genomics for CNTLN Gene

Regulatory Elements for CNTLN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNTLN Gene

17,134,982 bp from pter
17,503,923 bp from pter
368,942 bases
Plus strand

Genomic View for CNTLN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNTLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTLN Gene

Proteins for CNTLN Gene

  • Protein details for CNTLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A5Z2X6
    • Q5VYJ0
    • Q8N1G9
    • Q9HAJ5

    Protein attributes for CNTLN Gene

    1405 amino acids
    Molecular mass:
    161603 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91052.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13850.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CNTLN Gene


neXtProt entry for CNTLN Gene

Proteomics data for CNTLN Gene at MOPED

Post-translational modifications for CNTLN Gene

  • Ubiquitination at Lys 169
  • Modification sites at PhosphoSitePlus

Other Protein References for CNTLN Gene

No data available for DME Specific Peptides for CNTLN Gene

Domains & Families for CNTLN Gene

Protein Domains for CNTLN Gene


Suggested Antigen Peptide Sequences for CNTLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CNTLN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CNTLN Gene

Function for CNTLN Gene

Gene Ontology (GO) - Molecular Function for CNTLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000155 phosphorelay sensor kinase activity IEA --
GO:0019901 protein kinase binding IPI 24554434
GO:0019904 protein domain specific binding IPI 24554434
GO:0030674 protein binding, bridging IMP 24554434
genes like me logo Genes that share ontologies with CNTLN: view

Phenotypes for CNTLN Gene

GenomeRNAi human phenotypes for CNTLN:
genes like me logo Genes that share phenotypes with CNTLN: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNTLN

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CNTLN Gene

Localization for CNTLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTLN Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Colocalizes with gamma-tubulin during interphase and mitosis. Appears to associated with the mother centriole during G1 phase and with daughter centrioles towards G1/S phase (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CNTLN Gene COMPARTMENTS Subcellular localization image for CNTLN gene
Compartment Confidence
cytoskeleton 5
extracellular 5
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CNTLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 24554434
GO:0005814 centriole IDA 24554434
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CNTLN: view

Pathways & Interactions for CNTLN Gene

SuperPathways for CNTLN Gene

No Data Available

Interacting Proteins for CNTLN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9NXG0-CNTLN_HUMAN ENSP00000370021 for CNTLN Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CNTLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000160 phosphorelay signal transduction system IEA --
GO:0010457 centriole-centriole cohesion IMP 24554434
GO:0023014 signal transduction by protein phosphorylation IEA --
GO:0033365 protein localization to organelle IMP 24554434
genes like me logo Genes that share ontologies with CNTLN: view

No data available for Pathways by source and SIGNOR curated interactions for CNTLN Gene

Drugs & Compounds for CNTLN Gene

No Compound Related Data Available

Transcripts for CNTLN Gene

Unigene Clusters for CNTLN Gene

Centlein, centrosomal protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNTLN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTLN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP3: -

Relevant External Links for CNTLN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNTLN Gene

mRNA expression in normal human tissues for CNTLN Gene

Protein differential expression in normal tissues from HIPED for CNTLN Gene

This gene is overexpressed in Platelet (36.5), Plasma (12.9), and Urinary Bladder (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNTLN Gene

SOURCE GeneReport for Unigene cluster for CNTLN Gene Hs.435381

genes like me logo Genes that share expression patterns with CNTLN: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CNTLN Gene

Orthologs for CNTLN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNTLN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNTLN 35
  • 89.91 (n)
  • 84.26 (a)
  • 76 (a)
(Canis familiaris)
Mammalia CNTLN 35
  • 89.69 (n)
  • 85.32 (a)
  • 85 (a)
(Mus musculus)
Mammalia Cntln 35
  • 82.1 (n)
  • 77.71 (a)
Cntln 16
Cntln 36
  • 78 (a)
(Pan troglodytes)
Mammalia CNTLN 35
  • 98.96 (n)
  • 98.22 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Cntln 35
  • 81.32 (n)
  • 72.82 (a)
(Monodelphis domestica)
Mammalia CNTLN 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
-- 36
  • 59 (a)
(Gallus gallus)
Aves C9ORF39 35
  • 68.03 (n)
  • 56.72 (a)
-- 36
  • 62 (a)
-- 36
  • 56 (a)
(Anolis carolinensis)
Reptilia CNTLN 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cntln 35
  • 61.78 (n)
  • 50.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4694 35
(Danio rerio)
Actinopterygii si:ch211-2i17.1 35
  • 52.5 (n)
  • 42.66 (a)
cntln 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for CNTLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNTLN Gene

Gene Tree for CNTLN (if available)
Gene Tree for CNTLN (if available)

Paralogs for CNTLN Gene

(4) SIMAP similar genes for CNTLN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CNTLN: view

No data available for Paralogs for CNTLN Gene

Variants for CNTLN Gene

Sequence variations from dbSNP and Humsavar for CNTLN Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs393889 -- 17,133,614(+) gccta(G/T)ctttt upstream-variant-2KB
rs398527 -- 17,133,561(+) GTAGC(A/G)ATCAA upstream-variant-2KB
rs405861 -- 17,133,692(+) aatgg(A/G)gatat upstream-variant-2KB
rs421911 -- 17,133,629(+) tacca(C/G)acatg upstream-variant-2KB
rs431501 -- 17,133,682(+) cacta(G/T)taaaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CNTLN Gene

Variant ID Type Subtype PubMed ID
nsv892657 CNV Gain 21882294
dgv8114n71 CNV Gain 21882294
dgv8115n71 CNV Gain 21882294
nsv483026 CNV Loss 15286789
nsv471287 CNV Gain 18288195
nsv466269 CNV Gain 19166990
nsv892662 CNV Loss 21882294
nsv466270 CNV Loss 19166990
nsv892663 CNV Loss 21882294
nsv892664 CNV Loss 21882294
nsv892665 CNV Loss 21882294
nsv892666 CNV Loss 21882294
esv27469 CNV Loss 19812545
nsv892667 CNV Loss 21882294
esv268392 CNV Insertion 20981092
esv2738244 CNV Deletion 23290073
esv2666854 CNV Deletion 23128226
nsv416983 CNV Loss 16902084
nsv510184 CNV Loss 20534489
nsv892668 CNV Loss 21882294
nsv892669 CNV Loss 21882294
nsv892670 CNV Gain 21882294
nsv892671 CNV Gain 21882294
nsv466273 CNV Loss 19166990
nsv523411 CNV Gain 19592680
esv2422265 CNV Duplication 17116639
esv27473 CNV Loss 19812545
esv2661216 CNV Deletion 23128226
nsv526787 CNV Loss 19592680
nsv522698 CNV Loss 19592680

Variation tolerance for CNTLN Gene

Residual Variation Intolerance Score: 89.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.99; 93.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNTLN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTLN Gene

Disorders for CNTLN Gene

MalaCards: The human disease database

(4) MalaCards diseases for CNTLN Gene - From: DISEASES

Disorder Aliases PubMed IDs
seckel syndrome
  • microcephalic primordial dwarfism
joubert syndrome 1
  • joubert syndrome
meckel syndrome 1
  • meckel syndrome
leber congenital amaurosis
  • leber's amaurosis
- elite association
Search CNTLN in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNTLN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CNTLN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNTLN Gene

Publications for CNTLN Gene

  1. Identification and characterization of the novel centrosomal protein centlein. (PMID: 18086554) Makino K. … Nakanishi H. (Biochem. Biophys. Res. Commun. 2008) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. (PMID: 24554434) Fang G. … Yuan L. (J. Cell. Sci. 2014) 67
  4. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. (PMID: 23703321) New M. … La Thangue N.B. (Cell Death Differ. 2013) 67
  5. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M. … Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012) 67

Products for CNTLN Gene

Sources for CNTLN Gene

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