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CNTLN Gene

protein-coding   GIFtS: 51
GCID: GC09P017124

Centlein, Centrosomal Protein

(Previous names: chromosome 9 open reading frame 101, chromosome 9 open reading...)
(Previous symbols: C9orf101, C9orf39)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centlein, Centrosomal Protein1 2     Chromosome 9 Open Reading Frame 1011
C9orf1011 2 3 5     Chromosome 9 Open Reading Frame 391
C9orf391 2 3 5     bA340N12.12
Centrosomal Protein2 3     centlein2

External Ids:    HGNC: 234321   Entrez Gene: 548752   Ensembl: ENSG000000444597   OMIM: 6118705   UniProtKB: Q9NXG03   

Export aliases for CNTLN gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CNTLN Gene:
CNTLN (centlein, centrosomal protein) is a protein-coding gene. GO annotations related to this gene include phosphorelay sensor kinase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNTLN gene promoter:
         Elk-1   FOXF2   ATF-2   FOXD3   FOXO1a   Nkx2-5   c-Ets-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNTLN promoter sequence
   Search Chromatin IP Primers for CNTLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNTLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.2   Ensembl cytogenetic band:  9p22.2   HGNC cytogenetic band: 9p22.2-p22.1

CNTLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNTLN gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P017124:  view genomic region     (about GC identifiers)

Start:
17,134,980 bp from pter      End:
17,503,921 bp from pter
Size:
368,942 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CNTLN_HUMAN, Q9NXG0 (See protein sequence)
Recommended Name: Centlein  
Size: 1405 amino acids; 161603 Da
Sequence caution: Sequence=BAA91052.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB13850.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A5Z2X6 Q5VYJ0 Q8N1G9 Q9HAJ5
Alternative splicing: 3 isoforms:  Q9NXG0-1   Q9NXG0-2   Q9NXG0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNTLN: NX_Q9NXG0

Explore proteomics data for CNTLN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys169
  • Modification sites at PhosphoSitePlus

  • See CNTLN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001107867.1  NP_001273913.1  NP_001273914.1  NP_060208.2  

    ENSEMBL proteins: 
     ENSP00000370021   ENSP00000370015   ENSP00000392798   ENSP00000262360  

    CNTLN Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CNTLN

     
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    Abcam antibodies for CNTLN (Q9NXG0 , Q9NXG0)
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    LSBio Antibodies in human, mouse, rat for CNTLN

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    Search eBioscience for ELISAs for CNTLN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003661 EnvZ-like_dim/P

    Graphical View of Domain Structure for InterPro Entry Q9NXG0

    ProtoNet protein and cluster: Q9NXG0

    1 Blocks protein domain: IPB003661 Histidine kinase A


    Find genes that share domains with CNTLN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000155phosphorelay sensor kinase activity IEA--
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with CNTLN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CNTLN:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNTLN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNTLN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNTLN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNTLN

    miRNA
    Products:
        
    miRTarBase miRNAs that target CNTLN:
    hsa-mir-26b-5p (MIRT029145), hsa-mir-10a-5p (MIRT047533)

    Block miRNA regulation of human, mouse, rat CNTLN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNTLN (see all 39):
    hsa-miR-548j hsa-miR-579 hsa-miR-4291 hsa-miR-4307 hsa-miR-640 hsa-miR-136 hsa-miR-4328 hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidCNTLN 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CNTLN
    Predesigned siRNA for gene silencing in human, mouse, rat CNTLN

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    GenScript: all cDNA clones in your preferred vector (see all 2): CNTLN (NM_017738)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNTLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTLN

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTLN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNTLN_HUMAN, Q9NXG0: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
    Note=Colocalizes with gamma-tubulin during interphase and mitosis. Appears to associated with the mother
    centriole during G1 phase and with daughter centrioles towards G1/S phase (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    mitochondrion4
    nucleus3
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005813centrosome ----
    GO:0005814centriole IEA--
    GO:0016020membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CNTLN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNTLN
    Interactions:

        Search GeneGlobe Interaction Network for CNTLN

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CNTLN (Q9NXG03 ENSP000003700214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with CNTLN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNTLN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNTLN gene (4 alternative transcripts): 
    NM_001114395.2  NM_001286984.1  NM_001286985.1  NM_017738.3  

    Unigene Cluster for CNTLN:

    Centlein, centrosomal protein
    Hs.435381  [show with all ESTs]
    Unigene Representative Sequence: BX647069
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484374(uc003zmw.2) ENST00000380647(uc003zmz.2 uc003zmy.3 uc010mio.3)
    ENST00000380641(uc003zmx.4) ENST00000461247 ENST00000425824 ENST00000262360

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CNTLN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNTLN (see all 39):
    hsa-miR-548j hsa-miR-579 hsa-miR-4291 hsa-miR-4307 hsa-miR-640 hsa-miR-136 hsa-miR-4328 hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidCNTLN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CNTLN
    Predesigned siRNA for gene silencing in human, mouse, rat CNTLN
    Clone
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    OriGene ORF clones in mouse, rat for CNTLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CNTLN (NM_017738)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNTLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTLN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CNTLN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNTLN
      QuantiTect SYBR Green Assays in human, mouse, rat CNTLN
      QuantiFast Probe-based Assays in human, mouse, rat CNTLN

    Additional mRNA sequence: 

    AK000283.1 AK021596.1 AK098502.1 AK303973.1 AK308837.1 BX647069.1 

    9 DOTS entries:

    DT.109718  DT.121154456  DT.65288655  DT.40194604  DT.40221609  DT.100641615  DT.100726098  DT.91718288 
    DT.40256500 

    Selected AceView cDNA sequences (see all 65):

    AA481757 CR623494 AW628606 CA390168 AA828123 N68372 BP352672 AI699339 
    AA492222 AI745309 BG209351 CA419838 AA496789 BM461869 AA481021 AI792421 
    AL516906 AU118007 AA970997 BM479689 BG166427 AA329577 AW118219 AI816866 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CNTLN    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:                                                                                                                                                      
    SP2:                                                                                                                                                      
    SP3:                    -                                                                                                                                 
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for CNTLN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNTLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAAATTAT
    CNTLN Expression
    About this image

    CNTLN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNTLN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435381
        Custom PCR Arrays for CNTLN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CNTLN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cntln1 , 5 centlein, centrosomal protein1, 5 82.1(n)1
    77.71(a)1
      4 (40.20 cM)5
    3383491  NM_175275.41  NP_780484.21 
     848843095 
    chicken
    (Gallus gallus)
    Aves C9ORF391 centlein, centrosomal protein 68.03(n)
    56.72(a)
      769413  XM_001232684.3  XP_001232685.3 
    lizard
    (Anolis carolinensis)
    Reptilia CNTLN6
    centlein, centrosomal protein
    56(a)
    1 ↔ 1
    2(36095150-36340460)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.46942 Xenopus laevis transcribed sequence with weak similarity more 79.36(n)    CA973550.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-2i17.11 si:ch211-2i17.1 52.5(n)
    42.66(a)
      799510  XM_005159912.1  XP_005159969.1 


    ENSEMBL Gene Tree for CNTLN (if available)
    TreeFam Gene Tree for CNTLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNTLN gene
    4 SIMAP similar genes for CNTLN using alignment to 3 protein entries:     CNTLN_HUMAN (see all proteins):
    EEF1E1    DPP9    RBP7    TNNT1

    Find genes that share paralogs with CNTLN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNTLN (see all 9756)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424293101,2
    --17133145(+) ACCAGC/GCTCGG 2 -- us2k10--------
    rs1876191501,2
    --17133176(+) GCAGTC/TGTGAG 2 -- us2k10--------
    rs1512719771,2
    --17133188(+) TACCAC/TGCCTG 2 -- us2k10--------
    rs1911817461,2
    --17133250(+) ATTTTA/GTGTAT 2 -- us2k10--------
    rs1829041461,2
    --17133337(+) ATACAC/TATTTA 2 -- us2k10--------
    rs1871545281,2
    --17133454(+) AAACAC/TGTAAC 2 -- us2k10--------
    rs3985271,2
    C,F,H--17133559(+) GTAGCG/AATCAA 2 -- us2k1 tfbs311Minor allele frequency- A:0.15NS EA NA WA 1212
    rs1919560581,2
    --17133563(+) CGATCA/GAAGTA 2 -- us2k10--------
    rs4219111,2
    H--17133627(+) taccaG/Cacatg 2 -- us2k1 tfbs34Minor allele frequency- C:0.00NS EA 404
    rs1844212901,2
    --17133656(+) AGTAAA/CCTTGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNTLN (17134980 - 17384980 bp, first 250kb of CNTLN)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CNTLN (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738244CNV Deletion23290073
    esv2661216CNV Deletion23128226
    esv2666854CNV Deletion23128226
    esv2422265CNV Duplication17116639
    esv268392CNV Insertion20981092
    nsv892665CNV Loss21882294
    nsv892668CNV Loss21882294
    nsv466270CNV Loss19166990
    nsv466273CNV Loss19166990
    nsv892664CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNTLN
    DNA2.0 Custom Variant and Variant Library Synthesis for CNTLN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611870    OMIM disorders: --

    3 diseases from the University of Copenhagen DISEASES database for CNTLN:
    Seckel syndrome     Microcephaly     Leber congenital amaurosis

    Find genes that share disorders with CNTLN           About GenesLikeMe

    Genetic Association Database (GAD): CNTLN
    Human Genome Epidemiology (HuGE) Navigator: CNTLN (4 documents)

    Export disorders for CNTLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNTLN gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with CNTLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1, 4 Imboden M....Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. (PubMed id 19648919)1, 4 Song H....Gayther S.A. (Nat. Genet. 2009)
    5. Identification and characterization of the novel centrosomal protein centlein. (PubMed id 18086554)1, 3 Makino K....Nakanishi H. (Biochem. Biophys. Res. Commun. 2008)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. (PubMed id 23703321)1 New M....La Thangue N.B. (Cell Death Differ. 2013)
    10. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). (PubMed id 22952603)1 Hart A.B....Palmer A.A. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54875 HGNC: 23432 AceView: C9orf39 Ensembl:ENSG00000044459 euGenes: HUgn54875
    ECgene: CNTLN H-InvDB: CNTLN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CNTLN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CNTLN gene:
    Search GeneIP for patents involving CNTLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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