CNTLN Gene
protein-coding GIFtS: 49
GCID: GC09P017124
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centlein, centrosomal protein(Previous names: chromosome 9 open reading frame 101, chromosome 9 open...)
(Previous symbols: C9orf101, C9orf39)
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Aliases
for CNTLN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centlein, Centrosomal Protein1 2 | | OTTHUMG000000195971 | | C9orf1011 2 3 5 | | Chromosome 9 Open Reading Frame 1011 | | C9orf391 2 3 5 | | Chromosome 9 Open Reading Frame 391 | | BA340N12.11 | | RP11-340N12.12 | | Centrosomal Protein2 3 | | Centlein1 | | FLJ202761 | | |
Export aliases for CNTLN gene to outside databases |
Summaries
for CNTLN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CNTLN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CNTLN gene promoter:
Elk-1 FOXF2 ATF-2 FOXD3 FOXO1a Nkx2-5 c-Ets-1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNTLN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTLN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p22.2 Ensembl cytogenetic band: 9p22.2 HGNC cytogenetic band: 9p22.2-p22.1CNTLN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P017124: view genomic region
(about GC identifiers)
Start:
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17,134,980 bp from pter |
End:
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17,503,921 bp from pter |
Size:
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368,942 bases |
Orientation:
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plus strand |
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Proteins
for CNTLN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CNTLN_HUMAN, Q9NXG0 (See
protein sequence)Recommended Name: Centlein Size: 1405 amino acids; 161603 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Colocalizes with gamma-tubulin duringinterphase and mitosis. Appears to associated with the mother centriole during G1 phase and with daughter centriolestowards G1/S phase (By similarity)
Sequence caution: Sequence=BAA91052.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB13850.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A5Z2X6 Q5VYJ0 Q8N1G9 Q9HAJ5Alternative splicing: 3 isoforms: Q9NXG0-1 Q9NXG0-2 Q9NXG0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CNTLN: NX_Q9NXG0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXG0
CNTLN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001107867.1 NP_060208.2
ENSEMBL proteins: ENSP00000370021 ENSP00000370015 ENSP00000392798 ENSP00000262360
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CNTLN for ontologies About GeneDecksing
CNTLN Antibody Products:
Assay Products for CNTLN: |
Protein
Domains /
Families
for CNTLN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CNTLN for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NXG0ProtoNet protein and cluster: Q9NXG0 1 Blocks protein family: IPB003661 Histidine kinase A
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Function
for CNTLN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTLN (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTLN (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CNTLN (NM_017738) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNTLN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTLN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTLN |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000155 | phosphorelay sensor kinase activity |
IEA | -- |
CNTLN for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CNTLN:
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Pathways & Interactions
for CNTLN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNTLN
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CNTLN (Q9NXG03 ENSP000003700214) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CNTLN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CNTLN
Search CenterWatch for drugs/clinical trials and news about CNTLN
|
Transcripts
for CNTLN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CNTLN gene (2 alternative transcripts): NM_001114395.1 NM_017738.2 Unigene Cluster for CNTLN: Centlein, centrosomal protein Hs.435381 [show with all ESTs]Unigene Representative Sequence: BX6470696 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000484374(uc003zmw.2) ENST00000380647(uc003zmz.2 uc003zmy.3 uc010mio.3)
ENST00000380641(uc003zmx.4) ENST00000461247 ENST00000425824 ENST00000262360
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTLN (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTLN (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CNTLN (NM_017738) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNTLN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTLN |
Additional cDNA sequence: AK000283.1 AK021596.1 AK098502.1 AK303973.1 AK308837.1 BX647069.1 9 DOTS entries: DT.109718 DT.121154456 DT.65288655 DT.40194604 DT.40221609 DT.100641615 DT.100726098 DT.91718288 DT.40256500 24/65 AceView cDNA sequences (see all 65): CA390168 AA481757 AA828123 N68372 CR623494 AW628606 AI699339 BP352672 CA428767 AA329577 AA481021 BQ001648 AU118007 AL516906 BM461869 AA496789 AA492222 AI745309 CA419838 AI792421 BG209351 AI816866 AW118219 AA970997
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CNTLN About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CNTLN
|
Expression
for CNTLN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNTLN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAAATTAT
About this image
See CNTLN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNTLN
SOURCE GeneReport for Unigene cluster: Hs.435381
SABiosciences Custom PCR Arrays for CNTLN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNTLN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNTLN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNTLN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTLN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTLN |
Orthologs
for CNTLN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CNTLN gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for CNTLN (if available)
TreeFam Gene Tree for CNTLN (if available) |
Paralogs
for CNTLN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CNTLN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CNTLN (17134980 - 17384980 bp, first 250kb of CNTLN)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for CNTLN
6 CNVs: 65345 5260 0128 65347 95863 52762
3 Indels: 95864 82894 13157 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNTLN |
|
Disorders
/ Diseases
for CNTLN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CNTLN for disorders About GeneDecksing
OMIM gene information: 611870
OMIM disorders: --
7  diseases for CNTLN: About MalaCardssenior-loken syndrome leber congenital amaurosis seckel syndrome fanconi's anemia
cystic kidney microcephaly anemia
3 diseases from the University of Copenhagen DISEASES database for CNTLN:Seckel syndrome Microcephaly Leber congenital amaurosis Human Genome Epidemiology (HuGE) Navigator: CNTLN (4 documents)
Export disorders for CNTLN gene to outside databases
|
Publications
for CNTLN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CNTLN gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CNTLN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of the novel centrosomal protein centlein. (PubMed id 18086554)1, 3 Makino K....Nakanishi H. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1 Imboden M....Probst-Hensch N.M. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
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External Searches for CNTLN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CNTLN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CNTLN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CNTLN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CNTLN | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CNTLN gene:
Search GeneIP for patents involving CNTLN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CNTLN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CNTLN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNTLN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNTLN | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CNTLN | | OriGene 3'-UTR Clone for CNTLN | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTLN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTLN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CNTLN | | OriGene Custom Protein Services for CNTLN | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNTLN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNTLN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTLN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNTLN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTLN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNTLN |
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| | | | Search Tocris compounds for CNTLN |
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 | | | CNTLN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTLN |
|  |  |  | | | | Search ThermoFisher Antibodies for CNTLN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTLN |
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