CNTFR Gene

Aliases
for CNTFR gene

Previous GC identifers: GC09M034863 GC09M034720

Summaries
for CNTFR gene

Genomic Views
for CNTFR gene

RefSeq DNA sequence:

NC_000009.11  NC_018920.1  NT_008413.18  

SwitchGear Promoter luciferase reporter plasmid: CNTFR promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTFR

CNTFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M034541:  view genomic region     (about GC identifiers)

Proteins
for CNTFR gene

1 PDB 3D structure from and Proteopedia for CNTFR:

1UC6 (3D)    

Explore the universe of human proteins at neXtProt for CNTFR: NX_P26992

CNTFR Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CNTFR (CNTF R alpha)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CNTFR OriGene Protein Over-expression Lysate (see all 2): CNTFR OriGene Custom Protein Services for CNTFR
	GenScript Custom Purified and Recombinant Proteins Services for CNTFR
	Novus Biologicals CNTFR Protein Novus Biologicals CNTFR Lysate
	Sino Biological Recombinant Protein for CNTFR
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CNTFR

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CNTFR (CNTF R alpha)
	OriGene Antibodies: CNTFR OriGene Custom Antibody Services for CNTFR
	GenScript Custom Superior Antibodies Services for CNTFR
	Novus Biologicals CNTFR Antibodies
	Search for Antibodies for CNTFR at Abcam
	Uscn Antibodies for CNTFR
	ThermoFisher Antibodies for CNTFR

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CNTFR
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CNTFR

Protein Domains /
Families
for CNTFR gene

ProtoNet protein and cluster: P26992

Function
for CNTFR gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CNTFR Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNTFR
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate CNTFR (see all 44):
		hsa-miR-607 hsa-miR-429 hsa-miR-146a hsa-miR-765 hsa-miR-374a hsa-miR-486-3p hsa-miR-9 hsa-miR-637
		SwitchGear 3'UTR luciferase reporter plasmid: CNTFR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNTFR (see all 7) OriGene shRNA RFP: CNTFR OriGene siRNA: CNTFR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNTFR

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CNTFR

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTFR (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTFR (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CNTFR (NM_147164)
		Sino Biological Human cDNA Clone for CNTFR
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNTFR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTFR

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CNTFR
		Search LifeMap BioReagents cell lines for CNTFR

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTFR

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Cntfr)

Pathways & Interactions
for CNTFR gene

	Super-pathway	contained gene-specific pathways
1	Development_CNTF receptor signaling	Development CNTF receptor signaling 1.00 Development_CNTF receptor signaling 1.00
2	Adipogenesis	Adipogenesis 1.00
3	CNTF Signaling	CNTF Signaling 1.00
4	Jak-STAT signaling pathway	Jak-STAT signaling pathway 1.00
5	Notch Signaling Pathway	Delta-Notch Signaling Pathway 0.27

1 EMD Millipore Pathway for CNTFR

Development CNTF receptor signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CNTFR

CNTF Signaling

1 GeneGo (Thomson Reuters) Pathway for CNTFR

Development CNTF receptor signaling

2 BioSystems Pathways for CNTFR

	Adipogenesis
	Delta-Notch Signaling Pathway

2         Kegg Pathways  (Kegg details for CNTFR)

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for CNTFR gene

Transcripts
for CNTFR gene

Expression
for CNTFR gene

CNTFR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCTAACCC

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainHypothalamus			Brain
	BrainThalamus			Brain
	Neural TubeDiencephalic Ventricular Zone			Neural Tube
	Neural TubeTelencephalon			Neural Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNTFR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNTFR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNTFR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTFR

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTFR

Orthologs
for CNTFR gene

Paralogs
for CNTFR gene

Paralogs for CNTFR gene

IL11RA²  ENSG00000258728²  CRLF1²  IL6R²  EBI3²  

CNTFR for paralogs           About GeneDecksing

Genomic Variants
for CNTFR gene

10/644 NCBI SNPs in CNTFR are shown (see all 644)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1923689511,2		--	34550999(+)	TAGCAA/CCCCTG	3	--	ds5001		0	--	--	--	--
rs78687491,2	C,F,	--	34551249(+)	CAACTC/GTGTGC	3	--	ds5001		1		WA	118
rs727352741,2	C,F,	--	34551274(+)	ACCCCC/GCAAGA	3	--	ds5001		1		NA	120
rs1127025121,2	C,	--	34551446(+)	GTGACA/GTTTAA	3	--	ut31		0	--	--	--	--
rs1852605381,2		--	34551449(+)	ACGTTC/TAATGA	3	--	ut31		0	--	--	--	--
rs1486401401,2		--	34551682(+)	TAATCG/TGATGG	3	--	ut31		0	--	--	--	--
rs412748531,2	C,F,	--	34551896(+)	GTGCGG/ACAGGG	3	--	ut31		4		NA WA EA	242
rs1885798581,2		--	34551919(+)	AGGCCC/TGGGCC	3	--	ut31		0	--	--	--	--
rs1150349261,2	C,	--	34551920(+)	GGCCCA/GGGCCC	3	--	ut31		0	--	--	--	--
rs1927738521,2		--	34551929(+)	CCGCCA/GGGGTC	3	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for CNTFR (34551430 - 34590121 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CNTFR
     1 CNV: 9615

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNTFR

DNA2.0 Custom Variant and Variant Library Synthesis for CNTFR

Disorders / Diseases
for CNTFR gene

20/23 diseases for CNTFR

5 Novoseek disease relationships for CNTFR gene    About this table

Publications
for CNTFR gene

PubMed articles for CNTFR gene, integrated from 9 sources (see all 98): (articles sorted by number of sources associating them with CNTFR)

Utopia: connect your pdf to the dynamic world of online information

1. The receptor for ciliary neurotrophic factor. (PubMed id 1648265)^{1, 2, 3} Davis S.... Yancopoulos G.D. (1991)
2. Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. (PubMed id 12707266)^{1, 2, 9} Man D.... Ip N.Y. (2003)
3. C174T polymorphism in the CNTF receptor gene is associated with fat-free mass in men and women. (PubMed id 12807897)^{1, 4, 9} Roth S.M....Ferrell R.E. (2003)
4. Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor. (PubMed id 7774913)^{1, 2, 9} Valenzuela D.M....Yancopoulos G.D. (1995)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. (PubMed id 11294841)^{1, 9} Lelievre E....Gascan H. (2001)
7. Localization of the gene for the ciliary neurotrophic factor receptor (CNTFR) to human chromosome 9. (PubMed id 8244400)^{1, 9} Donaldson D.H....Patterson D. (1993)
8. Humanin inhibits neuronal cell death by interacting w ith a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX- 1/gp130. (PubMed id 19386761)^{1, 9} Hashimoto Y....Matsuoka M. (2009)
9. Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro. (PubMed id 11943154)^{1, 9} He W....Ip N.Y. (2002)
10. Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women. (PubMed id 17272411)^{1, 9} De Mars G....Thomis M.A. (2007)

External Searches for CNTFR gene

Genome Databases showing CNTFR gene

Other Databases showing CNTFR gene

Specialized Databases showing CNTFR gene

Products
for CNTFR gene