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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNTF Gene

protein-coding   GIFtS: 62
GCID: GC11P058390

Ciliary Neurotrophic Factor

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ciliary Neurotrophic Factor1 2
HCNTF2

External Ids:    HGNC: 21691   Entrez Gene: 12702   Ensembl: ENSG000002426897   OMIM: 1189455   UniProtKB: P264413   

Export aliases for CNTF gene to outside databases

Previous GC identifers: GC11P060741 GC11P059903 GC11P058641 GC11P058165 GC11P058146 GC11P054738


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNTF Gene:
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous
system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The
protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue
destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to
ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A
read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it
is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
(provided by RefSeq, Oct 2010)

GeneCards Summary for CNTF Gene: 
CNTF (ciliary neurotrophic factor) is a protein-coding gene. Diseases associated with CNTF include neurologic diseases, and spinal cord injury, and among its related super-pathways are FLT3 Signaling and Transcription Receptor-mediated HIF regulation. GO annotations related to this gene include growth factor activity and ciliary neurotrophic factor receptor binding.

UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441
Function: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor
axons after axotomy

Gene Wiki entry for CNTF (Ciliary neurotrophic factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNTF gene promoter:
         CREB   PPAR-gamma1   deltaCREB   MyoD   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CNTF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12

CNTF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNTF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P058390:  view genomic region     (about GC identifiers)

Start:
58,390,146 bp from pter      End:
58,393,206 bp from pter
Size:
3,061 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441 (See protein sequence)
Recommended Name: Ciliary neurotrophic factor  
Size: 200 amino acids; 22931 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for CNTF:
1CNT (3D)    
Secondary accessions: B2RAB2

Explore the universe of human proteins at neXtProt for CNTF: NX_P26441

Explore proteomics data for CNTF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26441

  • CNTF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNTF Protein Expression
    REFSEQ proteins: NP_000605.1  
    ENSEMBL proteins: 
     ENSP00000355370  

    Human Recombinant Protein Products for CNTF: 
    EMD Millipore Purified and/or Recombinant CNTF Protein
    R&D Systems Recombinant & Natural Proteins for CNTF
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    OriGene Protein Over-expression Lysate for CNTF
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    OriGene Custom Protein Services for CNTF
    GenScript Purified and Recombinant Proteins for CNTF
    Novus Biologicals CNTF Proteins
    Novus Biologicals CNTF Lysates
    Sino Biological Recombinant Protein for CNTF
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CNTF
    Cloud-Clone Corp. Proteins for CNTF 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IC12643274
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--
    GO:0097058colocalizes with CRLF-CLCF1 complex IDA10966616

    CNTF for ontologies           About GeneDecksing



    CNTF Antibody Products: 
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    ThermoFisher Antibodies for CNTF
    LSBio Antibodies in human, mouse, rat for CNTF 

    Assay Products for CNTF: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CNTF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNTF 
    Cloud-Clone Corp. CLIAs for CNTF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR000151 Ciliary_neurotrophic_fac_CNTF
     IPR009079 4_helix_cytokine-like_core

    Graphical View of Domain Structure for InterPro Entry P26441

    ProtoNet protein and cluster: P26441

    1 Blocks protein domain: IPB000151 Ciliary neurotrophic factor

    UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441
    Similarity: Belongs to the CNTF family


    CNTF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNTF_HUMAN, P26441
    Function: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor
    axons after axotomy

         Genatlas biochemistry entry for CNTF:
    ciliary neurotrophic factor,interleukin-6 cytokine family member,cytosolic protein,expressed in myelinating
    Schwann cells and astrocyte subpopulation,involved in axon out growth in retinal ganglion cells and in the spinal
    cord,with decreased expression in the lateral corticospinal tract of amyotrophic lateral sclerosis (ALS)

         Summary:
    During embryonic development, CNTF as signaling molecule
    affects the following cells: Late Retinal Progenitor Cells in Retinal Neuroblastic Layer

    CNTF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Motor neuron-like and interneuron-like cells from Neuron, Neural precursor spheres from Brain (see all).

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005127ciliary neurotrophic factor receptor binding TAS1714745
    GO:0005138interleukin-6 receptor binding IPI12643274
    GO:0008083growth factor activity IDA12643274
         
    CNTF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CNTF:
     Decreased Hepatitis C virus re 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cntf):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     muscle  nervous system  no phenotypic analysis 

    CNTF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CNTF: Cntftm1Gdy Cntftm1Mpin

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNTF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNTF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNTF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNTF 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNTF
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    hsa-miR-1294 hsa-miR-3153
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CNTF

    Clone
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    GenScript: all cDNA clones in your preferred vector: CNTF (NM_000614)
    Sino Biological Human cDNA Clone for CNTF
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                         Customized lentivirus expression plasmids for stable overexpression of CNTF 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CNTF About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CNTF Signaling
    CNTF Signaling0.50
    2Translation Insulin regulation of translation
    Development CNTF receptor signaling0.43
    3PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    4Notch signaling pathway
    Delta-Notch Signaling Pathway0.33
    5Jak-STAT signaling pathway
    Jak-STAT signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CNTF
        Development CNTF receptor signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CNTF
        CNTF Signaling

    1 GeneGo (Thomson Reuters) Pathway for CNTF
        Development CNTF receptor signaling

    1 BioSystems Pathway for CNTF
        Delta-Notch Signaling Pathway



    2         Kegg Pathways  (Kegg details for CNTF):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    CNTF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNTF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for CNTF (P264411, 2, 3 ENSP000003553704) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6STP401892, 3, ENSP000003387994MINT-62479 MINT-62480 I2D: score=2 STRING: ENSP00000338799
    STK16O757161, 3, ENSP000003799644EBI-1050897,EBI-749295 I2D: score=2 STRING: ENSP00000379964
    VHLP403371, 3EBI-1050897,EBI-301246 I2D: score=2 
    LIFRP427022, 3, ENSP000002634094MINT-62474 MINT-62473 I2D: score=3 STRING: ENSP00000263409
    EXT2Q930631, 3, ENSP000003426564EBI-1050897,EBI-1047761 I2D: score=2 STRING: ENSP00000342656
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS1840538
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0040007growth IEA--
    GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein IDA12643274
    GO:0043524negative regulation of neuron apoptotic process IDA10966616

    CNTF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CNTF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNTF

    10/59 Novoseek inferred chemical compound relationships for CNTF gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 94.3 225 17448148 (4), 9287306 (4), 12765290 (3), 7500350 (3) (see all 99)
    axokine 85.3 9 12861475 (1), 17971763 (1), 12610837 (1), 15340100 (1) (see all 6)
    tyrosine 56.8 53 12941469 (4), 9242633 (2), 9285712 (2), 7512571 (2) (see all 34)
    il 11 54 1 8605875 (1)
    choline 52.7 30 8034640 (3), 9476208 (2), 7760021 (2), 7891074 (2) (see all 13)
    quinolinic acid 49 14 12427308 (3), 8692996 (1), 9588602 (1), 9121555 (1) (see all 5)
    octadecaneuropeptide 48.8 2 15146610 (1), 15107726 (1)
    bupropion 20 3 16859393 (1), 17033290 (1), 17971763 (1)
    acetylcholine 16 13 9476208 (2), 9157328 (1), 19830843 (1), 12932444 (1) (see all 7)
    glutamate 12.6 21 11095495 (4), 1360545 (4), 10619557 (2), 19865482 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about CNTF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNTF gene: 
    NM_000614.3  

    Unigene Cluster for CNTF:

    Ciliary neurotrophic factor
    Hs.524920  [show with all ESTs]
    Unigene Representative Sequence: NM_053023
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361987(uc001nna.4)

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CNTF:
    hsa-miR-1294 hsa-miR-3153
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of CNTF 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTF

    Additional mRNA sequence: 

    AB056107.1 AF310246.1 AJ270692.1 AK025502.1 AK128303.1 AK295700.1 AK314118.1 BC051743.1 
    BC068030.1 BC069167.1 BC074963.2 BC074964.2 NR_024091.1 S72921.1 

    21 DOTS entries:

    DT.95331869  DT.452558  DT.455066  DT.99962886  DT.99933507  DT.307724  DT.65286271  DT.100038803 
    DT.102837608  DT.92417425  DT.101958415  DT.120748532  DT.95331866  DT.120748508  DT.75129424  DT.91966022 
    DT.95331872  DT.97763497  DT.121024439  DT.121025771  DT.87017426 

    24/493 AceView cDNA sequences (see all 493):

    BU192588 BM667429 AI076789 N62831 N72280 AI620699 AA585339 BF940393 
    AI380912 BU687289 BM548840 BM851264 AK025502 BX095716 BE049230 AI978617 
    BF477172 BM681742 AA811228 AA179521 AW275244 AW003047 NM_000614 BE886830 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNTF expression in normal human tissues (normalized intensities)      CNTF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGAGACAG
    CNTF Expression
    About this image


    CNTF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Thalamus
             Olfactory Bulb   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Retina
             Human retinal stem cells secreting CNTF
             lens   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Peripheral Nervous System (Nervous System)
             Myelinating Schwann Cells Peripheral Nerve Domain

    See CNTF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNTF

    SOURCE GeneReport for Unigene cluster: Hs.524920

    UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441
    Tissue specificity: Nervous system

        SABiosciences Expression via Pathway-Focused PCR Arrays including CNTF: 
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CNTF gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cntf1 , 5 ciliary neurotrophic factor1, 5 84.97(n)1
    83.42(a)1
      19 (8.73 cM)5
    128031  NM_170786.21  NP_740756.11 
     127636605 
    chicken
    (Gallus gallus)
    Aves CNTF1 ciliary neurotrophic factor 56.16(n)
    45.11(a)
      396488  NM_205492.1  NP_990823.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNTF6
    Uncharacterized protein
    45(a)
    1 ↔ 1
    1(91266272-91271918)


    ENSEMBL Gene Tree for CNTF (if available)
    TreeFam Gene Tree for CNTF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/156 SNPs in CNTF are shown (see all 156)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133198351,2
    C--54736726(+) CAGGTG/-GTTAA 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1452405601,2
    C--58308800(+) AATGTA/GCTCAA 1 -- us2k10--------
    rs1492032301,2
    --58308839(+) TTAAAA/GTATTT 1 -- us2k10--------
    rs1826339931,2
    --58309016(+) AGGCAC/TATTAA 1 -- us2k10--------
    rs25077621,2
    C,F--58309040(+) AAGAAG/AAAAAA 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1877604931,2
    --58309307(+) AAAACC/TGGCCA 1 -- us2k10--------
    rs1920614241,2
    --58309308(+) AAACTC/GGCCAT 1 -- us2k10--------
    rs1156503571,2
    C,F--58309470(+) AAACTA/GTAATC 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1840052751,2
    --58309595(+) TGGCAA/GTATCT 1 -- us2k10--------
    rs1876603581,2
    --58309608(+) GATATA/TAATAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNTF (58390146 - 58393206 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CNTF: --

    Human Gene Mutation Database (HGMD): CNTF
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CNTF
    DNA2.0 Custom Variant and Variant Library Synthesis for CNTF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 118945    OMIM disorders: --

    20/69 diseases for CNTF (see all 69):    About MalaCards
    neurologic diseases    spinal cord injury    acute disseminated encephalomyelitis    wallerian degeneration
    polyneuropathy    chronic inflammatory demyelinating polyneuropathy    demyelinating polyneuropathy    diabetic neuropathy
    diabetic polyneuropathy    motor neuron disease    learning disability    hereditary neuropathies
    huntington's disease    plasmodium falciparum malaria    prolactinoma    status epilepticus
    retinal degeneration    lateral sclerosis    amyotrophic lateral sclerosis    eating disorder

    3 diseases from the University of Copenhagen DISEASES database for CNTF:
    Amyotrophic lateral sclerosis     Retinal degeneration     Huntington's disease

    CNTF for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/57 Novoseek inferred disease relationships for CNTF gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 79.6 326 8187629 (6), 18240017 (5), 8034640 (5), 10362299 (3) (see all 99)
    amyotrophic lateral sclerosis 70.5 63 15266526 (4), 8971830 (3), 8543936 (2), 14656696 (2) (see all 31)
    motor neuron disease 66.4 30 8759781 (5), 8053649 (3), 7818257 (2), 9398466 (1) (see all 17)
    neurodegenerative diseases 55 11 8543936 (1), 14631864 (1), 9106250 (1), 7838303 (1) (see all 8)
    retinal degeneration 53.1 14 16505355 (2), 10235570 (2), 20209167 (2), 17325188 (1) (see all 8)
    huntington disease 50.5 27 9121555 (3), 8692996 (2), 9171158 (2), 14697316 (2) (see all 14)
    retinitis pigmentosa 46.3 10 17325188 (2), 16143329 (1), 17508034 (1), 18830926 (1) (see all 7)
    neurodegeneration 43.6 22 7585948 (1), 7585015 (1), 1641039 (1), 9171158 (1) (see all 11)
    response acute phase 43.5 7 8109896 (2), 12773095 (1), 8681311 (1), 8075593 (1) (see all 5)
    neurological disorders 40.6 10 8764576 (2), 7520198 (1), 8075647 (1), 15694712 (1) (see all 6)

    Genetic Association Database (GAD): CNTF
    Human Genome Epidemiology (HuGE) Navigator: CNTF (29 documents)

    Export disorders for CNTF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNTF gene, integrated from 9 sources (see all 672):
    (articles sorted by number of sources associating them with CNTF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. (PubMed id 1840538)1, 2, 3, 9 Lam A....Cordell B. (1991)
    2. The relationship between ciliary neurotrophic factor (CNTF) genotype and motor unit physiology: preliminary studies. (PubMed id 16181490)1, 4, 9 Conwit R.A....Metter E.J. (2005)
    3. Association of a null mutation in the CNTF gene with early onset of multiple sclerosis. (PubMed id 11890844)1, 4, 9 Giess R....Rieckmann P. (2002)
    4. Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli. (PubMed id 1883844)1, 2, 9 McDonald J.R.... Collins F. (1991)
    5. Cloning and expression of human ciliary neurotrophic factor. (PubMed id 1915374)1, 2, 9 Negro A.... Altruda F. (1991)
    6. Sex-specific effects of CNTF, IL6 and UCP2 polymorphi sms on weight gain. (PubMed id 19833146)1, 4, 9 Heidema A.G....Mariman E.C. (2010)
    7. Association study of BDNF and CNTF polymorphism to depression in non-demented subjects of the 'VITA' study. (PubMed id 16797081)1, 4, 9 Grunblatt E....Riederer P. (2006)
    8. No association between the CNTF null mutation and schizophrenia or personality. (PubMed id 16969278)1, 4, 9 Nishiyama J....Sasaki T. (2006)
    9. Meta-analyses of the association between genetic polymorphisms of neurotrophic factors and schizophrenia. (PubMed id 15474906)1, 4, 9 Lin P.Y. and Tsai G. (2004)
    10. Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women. (PubMed id 17272411)1, 4, 9 De Mars G....Thomis M.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1270 HGNC: 2169 AceView: CNTF Ensembl:ENSG00000242689 euGenes: HUgn1270
    ECgene: CNTF Kegg: 1270 H-InvDB: CNTF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNTF Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Ciliary_neurotrophic_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNTF gene:
    Search GeneIP for patents involving CNTF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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