Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CNTF Gene

protein-coding GIFtS: 61
GCID: GC11P058390

ciliary neurotrophic factor

Explore 77 diseases affiliated with
CNTF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ciliary Neurotrophic Factor¹ ²
HCNTF¹ ²

External Ids:	HGNC: 2169¹	Entrez Gene: 1270²	Ensembl: ENSG00000242689⁷	OMIM: 118945⁵	UniProtKB: P26441³

Export aliases for CNTF gene to outside databases

Previous GC identifers: GC11P060741 GC11P059903 GC11P058641 GC11P058165 GC11P058146 GC11P054738

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNTF:

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system

where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a

potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during

inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic

factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant

composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding.

Read-through transcription of ZFP91 and CNTF has also been observed in mouse. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441

Function: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons

after axotomy

Gene Wiki entry for CNTF (Ciliary neurotrophic factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CNTF gene promoter:
CREB PPAR-gamma1 deltaCREB MyoD PPAR-gamma2 NF-kappaB1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CNTF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12

CNTF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNTF gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P058390: view genomic region (about GC identifiers)

Start:	58,390,146 bp from pter	End:	58,393,206 bp from pter
Size:	3,061 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441 (See protein sequence)

Recommended Name: Ciliary neurotrophic factor

Size: 200 amino acids; 22931 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

1 PDB 3D structure from and Proteopedia for CNTF:

1CNT (3D)

Secondary accessions: B2RAB2

Explore the universe of human proteins at neXtProt for CNTF: NX_P26441

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P26441

CNTF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000605.1

ENSEMBL proteins:

ENSP00000355370

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CNTF Protein
	R&D Systems Recombinant & Natural Proteins for CNTF
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CNTF OriGene Custom Protein Services for CNTF
	GenScript Purified and Recombinant Proteins for CNTF
	Novus Biologicals CNTF Proteins Novus Biologicals CNTF Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CNTF
	Uscn Proteins for CNTF

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IC	12643274
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	--	--
GO:0030424	axon	--	--

CNTF for ontologies About GeneDecksing

CNTF Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CNTF
	R&D Systems Antibodies for CNTF
	OriGene Antibodies: CNTF OriGene Custom Antibody Services for CNTF
	GenScript Superior Antibodies for CNTF
	Novus Biologicals CNTF Antibodies
	Search for Antibodies for CNTF at Abcam
	Uscn Antibodies for CNTF
	ThermoFisher Antibodies for CNTF

Assay Products for CNTF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CNTF
	GenScript Custom Assay Services for CNTF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CNTF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CNTF for domains About GeneDecksing

3 InterPro domains/families:

IPR012351 4_helix_cytokine_core

IPR000151 Ciliary_neurotrophic_fac_CNTF

IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P26441

ProtoNet protein and cluster: P26441

1 Blocks protein family: IPB000151 Ciliary neurotrophic factor

UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441

Similarity: Belongs to the CNTF family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441

Function: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons

after axotomy

Genatlas biochemistry entry for CNTF:

ciliary neurotrophic factor,interleukin-6 cytokine family member,cytosolic protein,expressed in myelinating Schwann

cells and astrocyte subpopulation,involved in axon out growth in retinal ganglion cells and in the spinal cord,with

decreased expression in the lateral corticospinal tract of amyotrophic lateral sclerosis (ALS)

Summary:

During embryonic development, CNTF as signaling molecule

affects the following cells: Late Retinal Progenitor Cells in Neuroblastic Layer

CNTF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Motor neuron-like cells, Schwann-like cells (see all 4).

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNTF
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CNTF:
		hsa-miR-1294 hsa-miR-3153
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNTF (see all 7) OriGene shRNA RFP: CNTF OriGene siRNA: CNTF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNTF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CNTF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTF (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTF OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CNTF (NM_000614)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNTF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CNTF
		Search LifeMap BioReagents cell lines for CNTF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTF

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	--	--
GO:0005127	ciliary neurotrophic factor receptor binding	TAS	1714745
GO:0005138	interleukin-6 receptor binding	IPI	12643274
GO:0008083	growth factor activity	IDA	12643274

CNTF for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CNTF:

Decreased Hepatitis C virus re

Animal Models:
Mouse knock-outs for CNTF: Cntf^tm1Gdy Cntf^tm1Mpin
8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cntf):

behavior/neurological	cellular	hematopoietic system	homeostasis/metabolism	immune system
muscle	nervous system	no phenotypic analysis

CNTF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_CNTF receptor signaling

Development CNTF receptor signaling

1.00

Development_CNTF receptor signaling

1.00

CNTF Signaling

CNTF Signaling

1.00

Jak-STAT signaling pathway

Jak-STAT signaling pathway

1.00

Notch Signaling Pathway

Delta-Notch Signaling Pathway

0.27

PEDF Induced Signaling

Cytokine-cytokine receptor interaction

0.26

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CNTF

Development CNTF receptor signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CNTF

CNTF Signaling

1 GeneGo (Thomson Reuters) Pathway for CNTF

Development CNTF receptor signaling

1 BioSystems Pathway for CNTF

Delta-Notch Signaling Pathway

2 Kegg Pathways (Kegg details for CNTF):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

CNTF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CNTF

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/11 Interacting proteins for CNTF (P26441^{1, 2, 3} ENSP00000355370⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL6ST	P40189²^,³, ENSP00000338799⁴	MINT-62479 MINT-62480 I2D: score=2 STRING: ENSP00000338799
STK16	O75716¹^,³, ENSP00000379964⁴	EBI-1050897,EBI-749295 I2D: score=2 STRING: ENSP00000379964
VHL	P40337¹^,³	EBI-1050897,EBI-301246 I2D: score=2
LIFR	P42702²^,³, ENSP00000263409⁴	MINT-62474 MINT-62473 I2D: score=3 STRING: ENSP00000263409
EXT2	Q93063¹^,³, ENSP00000342656⁴	EBI-1050897,EBI-1047761 I2D: score=2 STRING: ENSP00000342656

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	NAS	1840538
GO:0007259	JAK-STAT cascade	--	--
GO:0007399	nervous system development	--	--
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	--	--

CNTF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CNTF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CNTF
10/59 Novoseek chemical compound relationships for CNTF gene (see all 59) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130	94.3	225	17448148 (4), 9287306 (4), 12765290 (3), 7500350 (3) (see all 99)
axokine	85.3	9	12861475 (1), 17971763 (1), 12610837 (1), 15340100 (1) (see all 6)
tyrosine	56.8	53	12941469 (4), 9242633 (2), 9285712 (2), 7512571 (2) (see all 34)
il 11	54	1	8605875 (1)
choline	52.7	30	8034640 (3), 9476208 (2), 7760021 (2), 7891074 (2) (see all 13)
quinolinic acid	49	14	12427308 (3), 8692996 (1), 9588602 (1), 9121555 (1) (see all 5)
octadecaneuropeptide	48.8	2	15146610 (1), 15107726 (1)
bupropion	20	3	16859393 (1), 17033290 (1), 17971763 (1)
acetylcholine	16	13	9476208 (2), 9157328 (1), 19830843 (1), 12932444 (1) (see all 7)
glutamate	12.6	21	11095495 (4), 1360545 (4), 10619557 (2), 19865482 (1) (see all 9)

Search CenterWatch for drugs/clinical trials and news about CNTF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CNTF gene:

NM_000614.3

Unigene Cluster for CNTF:

Ciliary neurotrophic factor

Hs.524920 [show with all ESTs]

Unigene Representative Sequence: NM_053023

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000361987(uc001nna.4)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNTF
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CNTF:
		hsa-miR-1294 hsa-miR-3153
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNTF (see all 7) OriGene shRNA RFP: CNTF OriGene siRNA: CNTF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNTF

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTF (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTF OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CNTF (NM_000614)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNTF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTF

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNTF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CNTF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNTF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTF

Additional cDNA sequence:

AB056107.1 AF310246.1 AJ270692.1 AK025502.1 AK128303.1 AK295700.1 AK314118.1 BC051743.1

BC068030.1 BC069167.1 BC074963.2 BC074964.2 NR_024091.1 S72921.1

21 DOTS entries:

DT.95331869 DT.452558 DT.455066 DT.99962886 DT.99933507 DT.307724 DT.65286271 DT.100038803

DT.102837608 DT.92417425 DT.101958415 DT.95331866 DT.120748508 DT.75129424 DT.91966022 DT.95331872

DT.97763497 DT.120748532 DT.121024439 DT.121025771 DT.87017426

24/493 AceView cDNA sequences (see all 493):

CK299809 BX383320 AA831592 BM548840 CA425830 N62831 BU788935 AW275211

AA765534 AA179521 AW516345 AI858235 N72280 BM667429 AA629762 BU619425

AI949929 AI281008 BM789867 BM670734 BC074964 BM470986 CA336703 D31537

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CNTF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGAGACAG

About this image

CNTF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

See CNTF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNTF

SOURCE GeneReport for Unigene cluster: Hs.524920

UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441

Tissue specificity: Nervous system

SABiosciences Expression via Pathway-Focused PCR Arrays including CNTF:

Neurotrophins & Receptors in human mouse rat

Obesity in human mouse rat

Cytokines & Chemokines in human mouse rat

Common Cytokines in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNTF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CNTF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNTF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CNTF gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cntf^{1 , 5}	ciliary neurotrophic factor^{1, 5}	84.97(n)¹ 83.42(a)¹		19 (8.73 cM)⁵ 12803¹ NM_170786.2¹ NP_740756.1¹ 12763660⁵
chicken (Gallus gallus)	Aves	CNTF¹	ciliary neurotrophic factor	56.16(n) 45.11(a)		396488 NM_205492.1 NP_990823.1
lizard (Anolis carolinensis)	Reptilia	CNTF⁶	--	45(a)	1 ↔ 1	1(91266272-91271164)

ENSEMBL Gene Tree for CNTF (if available)
TreeFam Gene Tree for CNTF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2507762^1,2	C,	--	54736563(+)	`AAGAAG/AAAAAA`	1	--	us2k¹		2		WA	120
rs113319835^1,2	C,	--	54736726(+)	`CAGGTG/-GTTAA`	1	--	us2k¹		1		CSA	2
rs74410196^1,2		--	54737412(+)	`TACCTA/TCCTCC`	1	--	us2k¹		0	--	--	--	--
rs74670543^1,2	C,F,	--	54737500(+)	`TTACCT/CTTAAA`	1	--	us2k¹		1		WA	118
rs78409652^1,2	F,	--	54737754(+)	`GATCAA/GATGGA`	1	--	us2k¹		1		WA	118
rs76835616^1,2		--	54738114(+)	`GGCACA/GAAAAT`	1	--	us2k¹		0	--	--	--	--
rs111389492^1,2	F	--	54738160(+)	`GCAGGG/ACGTGG`	1	--	us2k¹		1		CSA	6
rs34131586^1,2	C	--	54738411(+)	`ATCCTA/GTGTAA`	2	Y C	mis¹		3		NA	78
rs185736188^1,2	C,	--	54738800(+)	`TAGGAA/GGAGTA`	1	--	int¹		0	--	--	--	--
rs17152776^1,2	C,F,	--	54738874(+)	`CTTTTA/GGTATT`	1	--	int¹		4		NA WA	260

HapMap Linkage Disequilibrium report for CNTF (58390146 - 58393206 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CNTF: --
Human Gene Mutation Database (HGMD): CNTF

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNTF

DNA2.0 Custom Variant and Variant Library Synthesis for CNTF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CNTF for disorders           About GeneDecksing

OMIM gene information: 118945    OMIM disorders: --

20/77 diseases for CNTF (see all 77):    About MalaCards

spinal cord injury charcot-marie-tooth disease neurologic diseases amyotrophic lateral sclerosis

wallerian degeneration chronic inflammatory demyelinating polyneuropathy amyotrophic lateral sclerosis (als) demyelinating polyneuropathy

plasmodium falciparum malaria motor neuronopathy lateral sclerosis acute disseminated encephalomyelitis

status epilepticus polyneuropathy learning disability neuronitis

motor neuron disease muscular atrophy retinitis pigmentosa pituitary adenoma

3 diseases from the University of Copenhagen DISEASES database for CNTF:

Amyotrophic lateral sclerosis Retinal degeneration Huntington's disease

10/57 Novoseek disease relationships for CNTF gene (see all 57) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	79.6	326	8187629 (6), 18240017 (5), 8034640 (5), 10362299 (3) (see all 99)
amyotrophic lateral sclerosis	70.5	63	15266526 (4), 8971830 (3), 8543936 (2), 14656696 (2) (see all 31)
motor neuron disease	66.4	30	8759781 (5), 8053649 (3), 7818257 (2), 9398466 (1) (see all 17)
neurodegenerative diseases	55	11	8543936 (1), 14631864 (1), 9106250 (1), 7838303 (1) (see all 8)
retinal degeneration	53.1	14	16505355 (2), 10235570 (2), 20209167 (2), 17325188 (1) (see all 8)
huntington disease	50.5	27	9121555 (3), 8692996 (2), 9171158 (2), 14697316 (2) (see all 14)
retinitis pigmentosa	46.3	10	17325188 (2), 16143329 (1), 17508034 (1), 18830926 (1) (see all 7)
neurodegeneration	43.6	22	7585948 (1), 7585015 (1), 1641039 (1), 9171158 (1) (see all 11)
response acute phase	43.5	7	8109896 (2), 12773095 (1), 8681311 (1), 8075593 (1) (see all 5)
neurological disorders	40.6	10	8764576 (2), 7520198 (1), 8075647 (1), 15694712 (1) (see all 6)

Genetic Association Database (GAD): CNTF
Human Genome Epidemiology (HuGE) Navigator: CNTF (29 documents)

Export disorders for CNTF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CNTF gene, integrated from 9 sources (see all 668):
(articles sorted by number of sources associating them with CNTF)

Utopia: connect your pdf to the dynamic
world of online information

Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. (PubMed id 1840538)^{1, 2, 3, 9} Lam A....Cordell B. (1991)
The relationship between ciliary neurotrophic factor (CNTF) genotype and motor unit physiology: preliminary studies. (PubMed id 16181490)^{1, 4, 9} Conwit R.A....Metter E.J. (2005)
Association of a null mutation in the CNTF gene with early onset of multiple sclerosis. (PubMed id 11890844)^{1, 4, 9} Giess R....Rieckmann P. (2002)
Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli. (PubMed id 1883844)^{1, 2, 9} McDonald J.R.... Collins F. (1991)
Cloning and expression of human ciliary neurotrophic factor. (PubMed id 1915374)^{1, 2, 9} Negro A.... Altruda F. (1991)
Meta-analyses of the association between genetic polymorphisms of neurotrophic factors and schizophrenia. (PubMed id 15474906)^{1, 4, 9} Lin P.Y. and Tsai G. (2004)
Neuropoietic cytokines in the hematopoietic fold. (PubMed id 1714745)^{1, 3, 9} Bazan J.F. (1991)
Relation of weight maintenance and dietary restraint to peroxisome proliferator-activated receptor gamma2, glucocorticoid receptor, and ciliary neurotrophic factor polymorphisms. (PubMed id 16210701)^{1, 4, 9} Vogels N....Westerterp-Plantenga M.S. (2005)
A null mutation in the CNTF gene is not associated with early onset of multiple sclerosis. (PubMed id 12470191)^{1, 4, 9} Hoffmann V. and Hardt C. (2002)
Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. (PubMed id 7796798)^{1, 2, 9} McDonald N.Q.... Hendrickson W.A. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1270	HGNC: 2169	AceView: CNTF	Ensembl:ENSG00000242689	euGenes: HUgn1270
ECgene: CNTF	Kegg: 1270	H-InvDB: CNTF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CNTF	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Ciliary_neurotrophic_factor

Intellectual Property for CNTF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CNTF gene:
Search GeneIP for patents involving CNTF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of CNTF
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Purified and/or Recombinant CNTF Protein

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CNTF (CNTF)		Browse Cell Culture Products
	ELISAs for CNTF (CNTF)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for CNTF (CNTF)

	OriGene Antibodies for CNTF		OriGene shRNA RFP for CNTF
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNTF		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNTF
	OriGene Protein Over-expression Lysate for CNTF		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CNTF		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNTF		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNTF
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CNTF		OriGene Custom Protein Services for CNTF
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNTF
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNTF
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTF
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNTF
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNTF
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNTF

	GenScript Purified and Recombinant Proteins for CNTF		GenScript cDNA clones with any tag delivered in your preferred vector for CNTF
	GenScript Custom Assay Services for CNTF		GenScript Superior Antibodies for CNTF
	GenScript Custom overexpressing Cell Line Services for CNTF		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CNTF promoter
	Search Chromatin IP Primers for CNTF
	RT² qPCR Primer Assay in human, mouse, rat CNTF
	GNC Network for CNTF
	SABiosciences PCR Arrays including human, mouse, rat CNTF

Search Tocris compounds for CNTF

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CNTF antibodies
	CNTF proteins
	CNTF lysates

	Search for Antibodies for CNTF at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CNTF
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for CNTF

CNTF Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CNTF

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTF

	Browse SwitchGear 3'UTR luciferase reporter plasmids for CNTF
	Browse SwitchGear Promoter luciferase reporter plasmids for CNTF

ThermoFisher Antibodies for CNTF

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTF

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CNTF gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CNTF Gene

ciliary neurotrophic factor

Aliases
for CNTF gene

Summaries
for CNTF gene

Genomic Views
for CNTF gene

Proteins
for CNTF gene

Protein Domains /
Families
for CNTF gene

Function
for CNTF gene

Pathways & Interactions
for CNTF gene

Drugs & Compounds
for CNTF gene

Transcripts
for CNTF gene

Expression
for CNTF gene

Orthologs
for CNTF gene

Paralogs
for CNTF gene

Genomic Variants
for CNTF gene

Disorders / Diseases
for CNTF gene

Publications
for CNTF gene

External Searches for CNTF gene

Genome Databases showing CNTF gene

Other Databases showing CNTF gene

Specialized Databases showing CNTF gene

Intellectual Property
for CNTF gene

Products
for CNTF gene

View Random Gene

Neurodegenerative Diseases
Brain Tumors
Neurological Disorders
Parkinson Disease
glaucoma
Blindness
Glioma
PITUITARY ADENOMA
Malaria
Demyelination
Prolactinoma
Wallerian Degeneration
Gliosis
retinopathy
Paralysis
sensory neuropathy
Leukemia
Polyneuropathy
insulin sensitivity
Retinitis Pigmentosa
Alzheimers Disease
Ischemia
neurodegeneration
Schizophrenia
Hyperalgesia
disability
Amyotrophic Lateral Sclerosis
Response Acute Phase
Diabetic Neuropathies
Paranoia
Insulin Resistance
Motor Neuron Disease
Multiple Sclerosis
Inflammation
Demyelinating Diseases
INJECTION SITE REACTION
OBESITY
immunodeficiency
Atrophy
Hypertrophy
MYELOMA
Retinal Degeneration
psychiatric disorder
STROKE
neuron loss
Rheumatoid Arthritis
prostate cancer
Tumors
Carcinoma Embryonal
Metastasis
Necrosis
Muscular Atrophy Spinal
Neuropathology
Encephalitis
CNS Diseases
Psychotic
Huntington Disease

Advanced Search

Export list of displayed genes

CNTF Gene

ciliary neurotrophic factor

Aliasesfor CNTF gene

Summariesfor CNTF gene

Genomic Viewsfor CNTF gene

Proteinsfor CNTF gene

Protein Domains /Familiesfor CNTF gene

Functionfor CNTF gene

Pathways & Interactionsfor CNTF gene

Drugs & Compoundsfor CNTF gene

Transcriptsfor CNTF gene

Expression for CNTF gene

Orthologsfor CNTF gene

Paralogsfor CNTF gene

Genomic Variantsfor CNTF gene

Disorders / Diseasesfor CNTF gene

Publicationsfor CNTF gene

External Searches for CNTF gene

Genome Databases showing CNTF gene

Other Databases showing CNTF gene

Specialized Databases showing CNTF gene

Intellectual Propertyfor CNTF gene

Productsfor CNTF gene

View Random Gene

Aliases
for CNTF gene

Summaries
for CNTF gene

Genomic Views
for CNTF gene

Proteins
for CNTF gene

Protein Domains /
Families
for CNTF gene

Function
for CNTF gene

Pathways & Interactions
for CNTF gene

Drugs & Compounds
for CNTF gene

Transcripts
for CNTF gene

Expression
for CNTF gene

Orthologs
for CNTF gene

Paralogs
for CNTF gene

Genomic Variants
for CNTF gene

Disorders / Diseases
for CNTF gene

Publications
for CNTF gene

Intellectual Property
for CNTF gene

Products
for CNTF gene