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Aliases for CNTF Gene

Aliases for CNTF Gene

  • Ciliary Neurotrophic Factor 2 3
  • HCNTF 3

External Ids for CNTF Gene

Summaries for CNTF Gene

Entrez Gene Summary for CNTF Gene

  • The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]

GeneCards Summary for CNTF Gene

CNTF (Ciliary Neurotrophic Factor) is a Protein Coding gene. Diseases associated with CNTF include spinal cord injury and acute disseminated encephalomyelitis. Among its related pathways are PEDF Induced Signaling and CNTF Signaling. GO annotations related to this gene include growth factor activity and ciliary neurotrophic factor receptor binding.

UniProtKB/Swiss-Prot for CNTF Gene

  • CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy

Gene Wiki entry for CNTF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTF Gene

Genomics for CNTF Gene

Genomic Location for CNTF Gene

Start:
58,622,673 bp from pter
End:
58,625,733 bp from pter
Size:
3,061 bases
Orientation:
Plus strand

Genomic View for CNTF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNTF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTF Gene

Regulatory Elements for CNTF Gene

Proteins for CNTF Gene

  • Protein details for CNTF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26441-CNTF_HUMAN
    Recommended name:
    Ciliary neurotrophic factor
    Protein Accession:
    P26441
    Secondary Accessions:
    • B2RAB2

    Protein attributes for CNTF Gene

    Size:
    200 amino acids
    Molecular mass:
    22931 Da
    Quaternary structure:
    • Homodimer

    Three dimensional structures from OCA and Proteopedia for CNTF Gene

neXtProt entry for CNTF Gene

Proteomics data for CNTF Gene at MOPED

Post-translational modifications for CNTF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNTF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNTF Gene

Domains for CNTF Gene

UniProtKB/Swiss-Prot:

CNTF_HUMAN
Family:
  • Belongs to the CNTF family.:
    • P26441
genes like me logo Genes that share domains with CNTF: view

No data available for Gene Families for CNTF Gene

Function for CNTF Gene

Molecular function for CNTF Gene

GENATLAS Biochemistry: ciliary neurotrophic factor,interleukin-6 cytokine family member,cytosolic protein,expressed in myelinating Schwann cells and astrocyte subpopulation,involved in axon out growth in retinal ganglion cells and in the spinal cord,with decreased expression in the lateral corticospinal tract of amyotrophic lateral sclerosis (ALS)
UniProtKB/Swiss-Prot Function: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy

Gene Ontology (GO) - Molecular Function for CNTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005127 ciliary neurotrophic factor receptor binding TAS 1714745
GO:0005138 interleukin-6 receptor binding IPI 12643274
GO:0005515 protein binding IPI 25416956
GO:0008083 growth factor activity IDA 12643274
genes like me logo Genes that share ontologies with CNTF: view
genes like me logo Genes that share phenotypes with CNTF: view

Animal Models for CNTF Gene

MGI Knock Outs for CNTF:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CNTF Gene

Localization for CNTF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTF Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNTF Gene COMPARTMENTS Subcellular localization image for CNTF gene
Compartment Confidence
cytosol 3
extracellular 3
nucleus 3
cytoskeleton 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CNTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IC 12643274
GO:0005737 cytoplasm IEA --
GO:0097058 colocalizes_with CRLF-CLCF1 complex IDA 10966616
genes like me logo Genes that share ontologies with CNTF: view

Pathways for CNTF Gene

genes like me logo Genes that share pathways with CNTF: view

Pathways by source for CNTF Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CNTF Gene
1 Qiagen pathway for CNTF Gene
1 BioSystems pathway for CNTF Gene

Gene Ontology (GO) - Biological Process for CNTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 1840538
GO:0008284 positive regulation of cell proliferation IEA --
GO:0040007 growth IEA --
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein IDA 12643274
GO:0043524 negative regulation of neuron apoptotic process IDA 10966616
genes like me logo Genes that share ontologies with CNTF: view

Compounds for CNTF Gene

(59) Novoseek inferred chemical compound relationships for CNTF Gene

Compound -log(P) Hits PubMed IDs
gp 130 94.3 131
axokine 85.3 6
tyrosine 56.8 42
il 11 54 1
choline 52.7 19
genes like me logo Genes that share compounds with CNTF: view

Transcripts for CNTF Gene

mRNA/cDNA for CNTF Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(493) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNTF Gene

Ciliary neurotrophic factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNTF Gene

No ASD Table

Relevant External Links for CNTF Gene

GeneLoc Exon Structure for
CNTF
ECgene alternative splicing isoforms for
CNTF

Expression for CNTF Gene

mRNA expression in normal human tissues for CNTF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CNTF Gene

SOURCE GeneReport for Unigene cluster for CNTF Gene Hs.524920

mRNA Expression by UniProt/SwissProt for CNTF Gene

P26441-CNTF_HUMAN
Tissue specificity: Nervous system
genes like me logo Genes that share expressions with CNTF: view

Orthologs for CNTF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNTF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTF 36
  • 99.33 (n)
  • 98.5 (a)
CNTF 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNTF 36
  • 76.72 (n)
  • 73.87 (a)
CNTF 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNTF 36
  • 88.94 (n)
  • 86.43 (a)
CNTF 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cntf 36
  • 84.09 (n)
  • 82.23 (a)
Cntf 16
Cntf 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNTF 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cntf 36
  • 85.17 (n)
  • 84 (a)
chicken
(Gallus gallus)
Aves CNTF 36
  • 55.98 (n)
  • 45.11 (a)
CNTF 37
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNTF 37
  • 45 (a)
OneToOne
Species with no ortholog for CNTF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CNTF Gene

ENSEMBL:
Gene Tree for CNTF (if available)
TreeFam:
Gene Tree for CNTF (if available)

Paralogs for CNTF Gene

No data available for Paralogs for CNTF Gene

Variants for CNTF Gene

Sequence variations from dbSNP and Humsavar for CNTF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_013924 -
VAR_033777 -

Relevant External Links for CNTF Gene

HapMap Linkage Disequilibrium report
CNTF
Human Gene Mutation Database (HGMD)
CNTF

No data available for Structural Variations from Database of Genomic Variants (DGV) for CNTF Gene

Disorders for CNTF Gene

(3) University of Copenhagen DISEASES for CNTF Gene

(57) Novoseek inferred disease relationships for CNTF Gene

Disease -log(P) Hits PubMed IDs
leukemia 79.6 130
amyotrophic lateral sclerosis 70.5 47
motor neuron disease 66.4 24
neurodegenerative diseases 55 8
retinal degeneration 53.1 11

Relevant External Links for CNTF

Genetic Association Database (GAD)
CNTF
Human Genome Epidemiology (HuGE) Navigator
CNTF
genes like me logo Genes that share disorders with CNTF: view

No data available for UniProtKB/Swiss-Prot for CNTF Gene

Publications for CNTF Gene

  1. Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. (PMID: 1840538) Lam A. … Cordell B. (Gene 1991) 2 3 4 23
  2. Recombinant human and rat ciliary neurotrophic factors. (PMID: 1861138) Masiakowski P. … Panayotatos N. (J. Neurochem. 1991) 3 4 23
  3. Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli. (PMID: 1883844) McDonald J.R. … Collins F. (Biochim. Biophys. Acta 1991) 3 4 23
  4. Cloning and expression of human ciliary neurotrophic factor. (PMID: 1915374) Negro A. … Altruda F. (Eur. J. Biochem. 1991) 3 4 23
  5. A null mutation in the human CNTF gene is not causally related to neurological diseases. (PMID: 8075647) Takahashi R. … Deguchi T. (Nat. Genet. 1994) 3 4 23

Products for CNTF Gene

Sources for CNTF Gene

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