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CNTF Gene

protein-coding   GIFtS: 61
GCID: GC11P058390

Ciliary Neurotrophic Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ciliary Neurotrophic Factor1 2
HCNTF2

External Ids:    HGNC: 21691   Entrez Gene: 12702   Ensembl: ENSG000002426897   OMIM: 1189455   UniProtKB: P264413   

Export aliases for CNTF gene to outside databases

Previous GC identifers: GC11P060741 GC11P059903 GC11P058641 GC11P058165 GC11P058146 GC11P054738


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNTF Gene:
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous
system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The
protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue
destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to
ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A
read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it
is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
(provided by RefSeq, Oct 2010)

GeneCards Summary for CNTF Gene:
CNTF (ciliary neurotrophic factor) is a protein-coding gene. Diseases associated with CNTF include neurologic diseases, and spinal cord injury. GO annotations related to this gene include growth factor activity and ciliary neurotrophic factor receptor binding.

UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441
Function: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor
axons after axotomy

Gene Wiki entry for CNTF (Ciliary neurotrophic factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNTF gene promoter:
         CREB   PPAR-gamma1   deltaCREB   MyoD   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CNTF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNTF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12

CNTF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNTF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P058390:  view genomic region     (about GC identifiers)

Start:
58,390,146 bp from pter      End:
58,393,206 bp from pter
Size:
3,061 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441 (See protein sequence)
Recommended Name: Ciliary neurotrophic factor  
Size: 200 amino acids; 22931 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for CNTF:
1CNT (3D)    
Secondary accessions: B2RAB2

Explore the universe of human proteins at neXtProt for CNTF: NX_P26441

Explore proteomics data for CNTF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CNTF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000605.1  
    ENSEMBL proteins: 
     ENSP00000355370  

    CNTF Human Recombinant Protein Products:

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    Novus Biologicals CNTF Proteins
    Novus Biologicals CNTF Lysates
    Sino Biological Recombinant Protein for CNTF
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CNTF
    Cloud-Clone Corp. Proteins for CNTF

    CNTF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CNTF
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    Novus Biologicals CNTF Antibodies
    Abcam antibodies for CNTF (P26441, Q6NTB0)
    Cloud-Clone Corp. Antibodies for CNTF
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    LSBio Antibodies in human, mouse, rat for CNTF

    CNTF Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CNTF
    GenScript Custom Assay Services for CNTF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNTF
    Cloud-Clone Corp. CLIAs for CNTF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR000151 Ciliary_neurotrophic_fac_CNTF
     IPR009079 4_helix_cytokine-like_core

    Graphical View of Domain Structure for InterPro Entry P26441

    ProtoNet protein and cluster: P26441

    1 Blocks protein domain: IPB000151 Ciliary neurotrophic factor

    UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441
    Similarity: Belongs to the CNTF family


    CNTF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNTF_HUMAN, P26441
    Function: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor
    axons after axotomy

         Genatlas biochemistry entry for CNTF:
    ciliary neurotrophic factor,interleukin-6 cytokine family member,cytosolic protein,expressed in myelinating
    Schwann cells and astrocyte subpopulation,involved in axon out growth in retinal ganglion cells and in the spinal
    cord,with decreased expression in the lateral corticospinal tract of amyotrophic lateral sclerosis (ALS)

         Summary: 
    During embryonic development, CNTF as signaling molecule affects the following cells:
    Eye: Late Retinal Progenitor Cells (Retinal Neuroblastic Layer)

    CNTF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 4)      fully expand
    Spinal Cord: Precursor lateral motor column neuron EBs, Lateral motor column neuron-like cells      fully expand to see all 8 cells
    Brain: Oligodendrocyte-like cells, Caudal astroglia-like cells      fully expand to see all 7 cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005127ciliary neurotrophic factor receptor binding TAS1714745
    GO:0005138interleukin-6 receptor binding IPI12643274
    GO:0008083growth factor activity IDA12643274
         
    CNTF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CNTF:
     Decreased Hepatitis C virus re 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cntf):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     muscle  nervous system  no phenotypic analysis 

    CNTF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CNTF: Cntftm1Gdy Cntftm1Mpin

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNTF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNTF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNTF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNTF

    miRNA
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    Block miRNA regulation of human, mouse, rat CNTF using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CNTF:
    hsa-miR-1294 hsa-miR-3153
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CNTF
    Predesigned siRNA for gene silencing in human, mouse, rat CNTF

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CNTF

    Clone
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    GenScript: all cDNA clones in your preferred vector: CNTF (NM_000614)
    Sino Biological Human cDNA Clone for CNTF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNTF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTF

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CNTF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNTF_HUMAN, P26441: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular3
    nucleus3
    cytoskeleton2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IC12643274
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle ----
    GO:0097058colocalizes with CRLF-CLCF1 complex IDA10966616

    CNTF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNTF About    
    See pathways by source

    SuperPathContained pathways About
    1CNTF Signaling
    CNTF Signaling0.50
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    3Translation Insulin regulation of translation
    Development CNTF receptor signaling0.43
    4Notch signaling pathway (KEGG)
    Delta-Notch Signaling Pathway0.33
    5Jak-STAT signaling pathway
    Jak-STAT signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CNTF
        CNTF Signaling

    1 GeneGo (Thomson Reuters) Pathway for CNTF
        Development CNTF receptor signaling

    1 BioSystems Pathway for CNTF
        Delta-Notch Signaling Pathway



    2 Kegg Pathways  (Kegg details for CNTF):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    CNTF for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CNTF: 
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CNTF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for CNTF (P264411, 2, 3 ENSP000003553704) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6STP401892, 3, ENSP000003387994MINT-62479 MINT-62480 I2D: score=2 STRING: ENSP00000338799
    STK16O757161, 3, ENSP000003799644EBI-1050897,EBI-749295 I2D: score=2 STRING: ENSP00000379964
    VHLP403371, 3EBI-1050897,EBI-301246 I2D: score=2 
    LIFRP427022, 3, ENSP000002634094MINT-62474 MINT-62473 I2D: score=3 STRING: ENSP00000263409
    EXT2Q930631, 3, ENSP000003426564EBI-1050897,EBI-1047761 I2D: score=2 STRING: ENSP00000342656
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS1840538
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0040007growth IEA--
    GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein IDA12643274
    GO:0043524negative regulation of neuron apoptotic process IDA10966616

    CNTF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNTF

    Selected Novoseek inferred chemical compound relationships for CNTF gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 94.3 225 17448148 (4), 9287306 (4), 12765290 (3), 7500350 (3) (see all 99)
    axokine 85.3 9 12861475 (1), 17971763 (1), 12610837 (1), 15340100 (1) (see all 6)
    tyrosine 56.8 53 12941469 (4), 9242633 (2), 9285712 (2), 7512571 (2) (see all 34)
    il 11 54 1 8605875 (1)
    choline 52.7 30 8034640 (3), 9476208 (2), 7760021 (2), 7891074 (2) (see all 13)
    quinolinic acid 49 14 12427308 (3), 8692996 (1), 9588602 (1), 9121555 (1) (see all 5)
    octadecaneuropeptide 48.8 2 15146610 (1), 15107726 (1)
    bupropion 20 3 16859393 (1), 17033290 (1), 17971763 (1)
    acetylcholine 16 13 9476208 (2), 9157328 (1), 19830843 (1), 12932444 (1) (see all 7)
    glutamate 12.6 21 11095495 (4), 1360545 (4), 10619557 (2), 19865482 (1) (see all 9)



    CNTF for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CNTF gene: 
    NM_000614.3  

    Unigene Cluster for CNTF:

    Ciliary neurotrophic factor
    Hs.524920  [show with all ESTs]
    Unigene Representative Sequence: NM_053023
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361987(uc001nna.4)
    miRNA
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    hsa-miR-1294 hsa-miR-3153
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CNTF (NM_000614)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNTF
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNTF
      QuantiTect SYBR Green Assays in human, mouse, rat CNTF
      QuantiFast Probe-based Assays in human, mouse, rat CNTF

    Additional mRNA sequence: 

    AB056107.1 AF310246.1 AJ270692.1 AK025502.1 AK128303.1 AK295700.1 AK314118.1 BC051743.1 
    BC068030.1 BC069167.1 BC074963.2 BC074964.2 NR_024091.1 S72921.1 

    21 DOTS entries:

    DT.95331869  DT.452558  DT.455066  DT.99962886  DT.99933507  DT.307724  DT.65286271  DT.100038803 
    DT.102837608  DT.92417425  DT.101958415  DT.120748532  DT.95331866  DT.120748508  DT.75129424  DT.91966022 
    DT.95331872  DT.97763497  DT.121024439  DT.121025771  DT.87017426 

    Selected AceView cDNA sequences (see all 493):

    AA585339 AW675604 AW003047 BF940393 AL045405 AW078826 BM470986 AI978617 
    AI380912 AA831592 BM681742 N62831 AA334910 BM667330 BM761966 BF001904 
    AA765904 BG387694 AI521486 BF223092 BU676387 AW516345 AA610078 BM789867 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNTF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGAGACAG
    CNTF Expression
    About this image


    CNTF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)
             Human retinal stem cells secreting CNTF
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Myelinating Schwann Cells Peripheral Nerve Domain
             Schwann-like cells
     
     Spinal Cord (Nervous System)
             Motor neuron progenitor cells
     
     Neurons
             Motor neuron progenitor cells
    CNTF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNTF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524920

    UniProtKB/Swiss-Prot: CNTF_HUMAN, P26441
    Tissue specificity: Nervous system

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CNTF: 
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CNTF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNTF
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    QuantiFast Probe-based Assays in human, mouse, rat CNTF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CNTF gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cntf1 , 5 ciliary neurotrophic factor1, 5 84.09(n)1
    82.23(a)1
      19 (8.73 cM)5
    128031  NM_170786.21  NP_740756.11 
     127636605 
    chicken
    (Gallus gallus)
    Aves CNTF1 ciliary neurotrophic factor 55.98(n)
    45.11(a)
      396488  NM_205492.1  NP_990823.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNTF6
    ciliary neurotrophic factor
    45(a)
    1 ↔ 1
    1(91266272-91271918)


    ENSEMBL Gene Tree for CNTF (if available)
    TreeFam Gene Tree for CNTF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNTF (see all 156)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133198351,2
    C--54736726(+) CAGGTG/-GTTAA 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1452405601,2
    C--58308800(+) AATGTA/GCTCAA 1 -- us2k10--------
    rs1492032301,2
    --58308839(+) TTAAAA/GTATTT 1 -- us2k10--------
    rs1826339931,2
    --58309016(+) AGGCAC/TATTAA 1 -- us2k10--------
    rs25077621,2
    C,F--58309040(+) AAGAAG/AAAAAA 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1877604931,2
    --58309307(+) AAAACC/TGGCCA 1 -- us2k10--------
    rs1920614241,2
    --58309308(+) AAACTC/GGCCAT 1 -- us2k10--------
    rs1156503571,2
    C,F--58309470(+) AAACTA/GTAATC 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1840052751,2
    --58309595(+) TGGCAA/GTATCT 1 -- us2k10--------
    rs1876603581,2
    --58309608(+) GATATA/TAATAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNTF (58390146 - 58393206 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CNTF: --
    Human Gene Mutation Database (HGMD): CNTF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNTF
    DNA2.0 Custom Variant and Variant Library Synthesis for CNTF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118945    OMIM disorders: --

    Selected diseases for CNTF (see all 70):    
    About MalaCards
    neurologic diseases    spinal cord injury    wallerian degeneration    acute disseminated encephalomyelitis
    polyneuropathy    chronic inflammatory demyelinating polyneuropathy    demyelinating polyneuropathy    motor neuron disease
    diabetic neuropathy    diabetic polyneuropathy    learning disability    huntington's disease
    hereditary neuropathies    plasmodium falciparum malaria    status epilepticus    prolactinoma
    retinal degeneration    eating disorder    cerebral palsy    malaria

    3 diseases from the University of Copenhagen DISEASES database for CNTF:
    Amyotrophic lateral sclerosis     Retinal degeneration     Huntington's disease

    CNTF for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CNTF gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 79.6 326 8187629 (6), 18240017 (5), 8034640 (5), 10362299 (3) (see all 99)
    amyotrophic lateral sclerosis 70.5 63 15266526 (4), 8971830 (3), 8543936 (2), 14656696 (2) (see all 31)
    motor neuron disease 66.4 30 8759781 (5), 8053649 (3), 7818257 (2), 9398466 (1) (see all 17)
    neurodegenerative diseases 55 11 8543936 (1), 14631864 (1), 9106250 (1), 7838303 (1) (see all 8)
    retinal degeneration 53.1 14 16505355 (2), 10235570 (2), 20209167 (2), 17325188 (1) (see all 8)
    huntington disease 50.5 27 9121555 (3), 8692996 (2), 9171158 (2), 14697316 (2) (see all 14)
    retinitis pigmentosa 46.3 10 17325188 (2), 16143329 (1), 17508034 (1), 18830926 (1) (see all 7)
    neurodegeneration 43.6 22 7585948 (1), 7585015 (1), 1641039 (1), 9171158 (1) (see all 11)
    response acute phase 43.5 7 8109896 (2), 12773095 (1), 8681311 (1), 8075593 (1) (see all 5)
    neurological disorders 40.6 10 8764576 (2), 7520198 (1), 8075647 (1), 15694712 (1) (see all 6)

    Genetic Association Database (GAD): CNTF
    Human Genome Epidemiology (HuGE) Navigator: CNTF (29 documents)

    Export disorders for CNTF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNTF gene, integrated from 10 sources (see all 674):
    (articles sorted by number of sources associating them with CNTF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. (PubMed id 1840538)1, 2, 3, 9 Lam A....Cordell B. (Gene 1991)
    2. The relationship between ciliary neurotrophic factor (CNTF) genotype and motor unit physiology: preliminary studies. (PubMed id 16181490)1, 4, 9 Conwit R.A....Metter E.J. (BMC Physiol. 2005)
    3. Association of a null mutation in the CNTF gene with early onset of multiple sclerosis. (PubMed id 11890844)1, 4, 9 Giess R....Rieckmann P. (Arch. Neurol. 2002)
    4. Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli. (PubMed id 1883844)1, 2, 9 McDonald J.R.... Collins F. (Biochim. Biophys. Acta 1991)
    5. Cloning and expression of human ciliary neurotrophic factor. (PubMed id 1915374)1, 2, 9 Negro A.... Altruda F. (Eur. J. Biochem. 1991)
    6. Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain. (PubMed id 19833146)1, 4, 9 Heidema A.G....Mariman E.C. (amp 2010)
    7. Association study of BDNF and CNTF polymorphism to depression in non-demented subjects of the &quot;VITA&quot; study. (PubMed id 16797081)1, 4, 9 GrA1nblatt E....Riederer P. (J Affect Disord 2006)
    8. No association between the CNTF null mutation and schizophrenia or personality. (PubMed id 16969278)1, 4, 9 Nishiyama J....Sasaki T. (Psychiatr. Genet. 2006)
    9. Meta-analyses of the association between genetic polymorphisms of neurotrophic factors and schizophrenia. (PubMed id 15474906)1, 4, 9 Lin P.Y. and Tsai G. (Schizophr. Res. 2004)
    10. Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women. (PubMed id 17272411)1, 4, 9 De Mars G....Thomis M.A. (J. Appl. Physiol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1270 HGNC: 2169 AceView: CNTF Ensembl:ENSG00000242689 euGenes: HUgn1270
    ECgene: CNTF Kegg: 1270 H-InvDB: CNTF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CNTF Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Ciliary_neurotrophic_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNTF gene:
    Search GeneIP for patents involving CNTF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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