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Aliases for CNTD2 Gene

Aliases for CNTD2 Gene

  • Cyclin N-Terminal Domain Containing 2 2 3 5
  • Cyclin P 2 3
  • Cyclin N-Terminal Domain-Containing Protein 2 3
  • CCNP 3

External Ids for CNTD2 Gene

Previous GeneCards Identifiers for CNTD2 Gene

  • GC19M045420
  • GC19M040728
  • GC19M037163

Summaries for CNTD2 Gene

GeneCards Summary for CNTD2 Gene

CNTD2 (Cyclin N-Terminal Domain Containing 2) is a Protein Coding gene. Diseases associated with CNTD2 include Cataract 27, Nuclear Progressive. GO annotations related to this gene include protein kinase binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTD2 Gene

Genomics for CNTD2 Gene

Regulatory Elements for CNTD2 Gene

Enhancers for CNTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CNTD2 on UCSC Golden Path with GeneCards custom track

Promoters for CNTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CNTD2 Gene

40,222,208 bp from pter
40,227,095 bp from pter
4,888 bases
Minus strand

Genomic View for CNTD2 Gene

Genes around CNTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTD2 Gene

Proteins for CNTD2 Gene

  • Protein details for CNTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin N-terminal domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DX65

    Protein attributes for CNTD2 Gene

    307 amino acids
    Molecular mass:
    33574 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNTD2 Gene


neXtProt entry for CNTD2 Gene

Post-translational modifications for CNTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNTD2 Gene

No data available for DME Specific Peptides for CNTD2 Gene

Domains & Families for CNTD2 Gene

Protein Domains for CNTD2 Gene


Suggested Antigen Peptide Sequences for CNTD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 cyclin N-terminal domain.
  • Contains 1 cyclin N-terminal domain.
genes like me logo Genes that share domains with CNTD2: view

No data available for Gene Families for CNTD2 Gene

Function for CNTD2 Gene

genes like me logo Genes that share phenotypes with CNTD2: view

Animal Model Products

CRISPR Products

miRNA for CNTD2 Gene

miRTarBase miRNAs that target CNTD2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNTD2 Gene

Localization for CNTD2 Gene

Subcellular locations from

Jensen Localization Image for CNTD2 Gene COMPARTMENTS Subcellular localization image for CNTD2 gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CNTD2 Gene

Pathways & Interactions for CNTD2 Gene

SuperPathways for CNTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CNTD2 Gene

Drugs & Compounds for CNTD2 Gene

No Compound Related Data Available

Transcripts for CNTD2 Gene

mRNA/cDNA for CNTD2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNTD2 Gene

Cyclin N-terminal domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTD2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: -

Relevant External Links for CNTD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNTD2 Gene

mRNA expression in normal human tissues for CNTD2 Gene

mRNA differential expression in normal tissues according to GTEx for CNTD2 Gene

This gene is overexpressed in Brain - Cerebellum (x10.7), Brain - Cerebellar Hemisphere (x10.0), Kidney - Cortex (x5.5), and Liver (x4.3).

Protein differential expression in normal tissues from HIPED for CNTD2 Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNTD2 Gene

Protein tissue co-expression partners for CNTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNTD2 Gene:


SOURCE GeneReport for Unigene cluster for CNTD2 Gene:

genes like me logo Genes that share expression patterns with CNTD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CNTD2 Gene

Orthologs for CNTD2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CNTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNTD2 34
  • 82.91 (n)
  • 81.39 (a)
CNTD2 35
  • 78 (a)
(Canis familiaris)
Mammalia CNTD2 34
  • 78.94 (n)
  • 77.43 (a)
CNTD2 35
  • 49 (a)
(Pan troglodytes)
Mammalia CNTD2 34
  • 98.59 (n)
  • 97.72 (a)
CNTD2 35
  • 98 (a)
Species where no ortholog for CNTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CNTD2 Gene

Gene Tree for CNTD2 (if available)
Gene Tree for CNTD2 (if available)

Paralogs for CNTD2 Gene

(3) SIMAP similar genes for CNTD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CNTD2: view

No data available for Paralogs for CNTD2 Gene

Variants for CNTD2 Gene

Sequence variations from dbSNP and Humsavar for CNTD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10853739 -- 40,228,681(+) aaaaa(A/T)atata upstream-variant-2KB
rs4239504 -- 40,222,129(+) CCAAT(C/T)AGAGG downstream-variant-500B
rs11301448 -- 40,225,063(+) TTCAC(-/T)TTTTT intron-variant
rs4490099 -- 40,225,584(+) ttttt(A/G)gctcc intron-variant
rs11671259 -- 40,226,688(+) TGCAG(A/C)TAGGG nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CNTD2 Gene

Variant ID Type Subtype PubMed ID
esv2758761 CNV gain 17122850
esv3644344 CNV gain 21293372
esv3644345 CNV gain 21293372

Variation tolerance for CNTD2 Gene

Gene Damage Index Score: 1.33; 26.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTD2 Gene

Disorders for CNTD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CNTD2 Gene - From: OMIM

Disorder Aliases PubMed IDs
cataract 27, nuclear progressive
- elite association - COSMIC cancer census association via MalaCards
Search CNTD2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNTD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CNTD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNTD2 Gene

Publications for CNTD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. Can sequencing shed light on cell cycling? (PMID: 11237006) Murray A.W. … Marks D. (Nature 2001) 2 3 65
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 65
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 65

Products for CNTD2 Gene

Sources for CNTD2 Gene

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