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Aliases for CNTD2 Gene

Aliases for CNTD2 Gene

  • Cyclin N-Terminal Domain Containing 2 2 3 5
  • Cyclin P 2 3
  • Cyclin N-Terminal Domain-Containing Protein 2 3
  • CCNP 3

External Ids for CNTD2 Gene

Previous GeneCards Identifiers for CNTD2 Gene

  • GC19M045420
  • GC19M040728
  • GC19M037163

Summaries for CNTD2 Gene

GeneCards Summary for CNTD2 Gene

CNTD2 (Cyclin N-Terminal Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTD2 Gene

Genomics for CNTD2 Gene

Regulatory Elements for CNTD2 Gene

Enhancers for CNTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F040190 0.9 FANTOM5 ENCODE 12.1 +35.9 35868 2.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 KLF13 TTC9B CNTD2 RPS16 ZNF546 ENSG00000269069 HIPK4 EID2B C19orf47 PLD3 ENSG00000206925
GH19F040139 0.7 ENCODE 11.9 +87.1 87107 0.2 INSM2 KLF17 FEZF1 ZNF2 RAD21 ZEB1 RFX5 ZNF335 GLIS2 ZNF654 TTC9B CNTD2 HIPK4 ENSG00000206925 C19orf47 PLD3 GC19M040148 VN1R96P
GH19F040155 0.9 Ensembl 11.7 +71.1 71095 0.4 ELF3 CTCF ZNF133 ZNF266 ZNF2 RAD21 RFX5 ZNF23 ZNF316 ZBTB48 ENSG00000269069 TTC9B CNTD2 ZNF546 HIPK4 PIR31992 GC19M040160 GC19M040148
GH19F040157 0.5 ENCODE 11.7 +69.9 69867 0.2 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207 SNRPA FBL ENSG00000269843 ITPKC RPS16 CYP2F2P RN7SL566P TTC9B CNTD2 ZNF546
GH19F040165 0.8 Ensembl ENCODE 11.5 +61.5 61473 0.4 CTCF ZNF2 RAD21 ZFHX2 ZBTB48 PATZ1 ZNF143 SMC3 ZNF391 EGR2 TTC9B CNTD2 ZNF780A GC19M039966 MAP3K10
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CNTD2 on UCSC Golden Path with GeneCards custom track

Promoters for CNTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001817556 795 201 CTCF RNF2 FEZF1 ZSCAN9 ZIC2 ZFHX2 ZNF692 GABPB1 MXD3 GLIS1

Genomic Location for CNTD2 Gene

Chromosome:
19
Start:
40,222,208 bp from pter
End:
40,227,095 bp from pter
Size:
4,888 bases
Orientation:
Minus strand

Genomic View for CNTD2 Gene

Genes around CNTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTD2 Gene

Proteins for CNTD2 Gene

  • Protein details for CNTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8S5-CNTD2_HUMAN
    Recommended name:
    Cyclin N-terminal domain-containing protein 2
    Protein Accession:
    Q9H8S5
    Secondary Accessions:
    • B4DX65

    Protein attributes for CNTD2 Gene

    Size:
    307 amino acids
    Molecular mass:
    33574 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNTD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNTD2 Gene

Post-translational modifications for CNTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNTD2 Gene

No data available for DME Specific Peptides for CNTD2 Gene

Domains & Families for CNTD2 Gene

Protein Domains for CNTD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNTD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H8S5

UniProtKB/Swiss-Prot:

CNTD2_HUMAN :
  • Contains 1 cyclin N-terminal domain.
Domain:
  • Contains 1 cyclin N-terminal domain.
genes like me logo Genes that share domains with CNTD2: view

No data available for Gene Families for CNTD2 Gene

Function for CNTD2 Gene

genes like me logo Genes that share phenotypes with CNTD2: view

Animal Model Products

miRNA for CNTD2 Gene

miRTarBase miRNAs that target CNTD2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNTD2 Gene

Localization for CNTD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNTD2 Gene COMPARTMENTS Subcellular localization image for CNTD2 gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CNTD2 Gene

Pathways & Interactions for CNTD2 Gene

SuperPathways for CNTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CNTD2 Gene

Transcripts for CNTD2 Gene

mRNA/cDNA for CNTD2 Gene

Unigene Clusters for CNTD2 Gene

Cyclin N-terminal domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTD2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: -

Relevant External Links for CNTD2 Gene

GeneLoc Exon Structure for
CNTD2
ECgene alternative splicing isoforms for
CNTD2

Expression for CNTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNTD2 Gene

mRNA differential expression in normal tissues according to GTEx for CNTD2 Gene

This gene is overexpressed in Brain - Cerebellum (x10.7), Brain - Cerebellar Hemisphere (x10.0), Kidney - Cortex (x5.5), and Liver (x4.3).

Protein differential expression in normal tissues from HIPED for CNTD2 Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNTD2 Gene



Protein tissue co-expression partners for CNTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNTD2 Gene:

CNTD2

SOURCE GeneReport for Unigene cluster for CNTD2 Gene:

Hs.631603
genes like me logo Genes that share expression patterns with CNTD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CNTD2 Gene

Orthologs for CNTD2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CNTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTD2 34 35
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia CNTD2 34 35
  • 82.91 (n)
dog
(Canis familiaris)
Mammalia CNTD2 34 35
  • 78.94 (n)
Species where no ortholog for CNTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CNTD2 Gene

ENSEMBL:
Gene Tree for CNTD2 (if available)
TreeFam:
Gene Tree for CNTD2 (if available)

Paralogs for CNTD2 Gene

(3) SIMAP similar genes for CNTD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CNTD2: view

No data available for Paralogs for CNTD2 Gene

Variants for CNTD2 Gene

Sequence variations from dbSNP and Humsavar for CNTD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10421153 -- 40,224,372(+) CCCCT(C/T)CCTCA intron-variant
rs10853739 -- 40,228,681(+) aaaaa(A/T)atata upstream-variant-2KB
rs111628764 -- 40,223,979(+) TTTTT(G/T)TTGTT intron-variant
rs112906736 -- 40,223,270(+) CAAAG(A/G)CAGCT nc-transcript-variant, reference, missense
rs11301448 -- 40,225,063(+) TTCAC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNTD2 Gene

Variant ID Type Subtype PubMed ID
esv2758761 CNV gain 17122850
esv3644344 CNV gain 21293372
esv3644345 CNV gain 21293372

Variation tolerance for CNTD2 Gene

Gene Damage Index Score: 1.33; 26.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTD2 Gene

Disorders for CNTD2 Gene

Relevant External Links for CNTD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNTD2

No disorders were found for CNTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNTD2 Gene

Publications for CNTD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Can sequencing shed light on cell cycling? (PMID: 11237006) Murray A.W. … Marks D. (Nature 2001) 2 3 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for CNTD2 Gene

Sources for CNTD2 Gene

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