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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNTD2 Gene

protein-coding   GIFtS: 40
GCID: GC19M040728

cyclin N-terminal domain containing 2
  Search for CNTD2
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CNTD2    

Aliases
for CNTD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin N-Terminal Domain Containing 21 2
FLJ132651
Cyclin N-Terminal Domain-Containing Protein 22

External Ids:    HGNC: 258051   Entrez Gene: 799352   Ensembl: ENSG000001052197   UniProtKB: Q9H8S53   

Export aliases for CNTD2 gene to outside databases

Previous GC identifers: GC19M045420 GC19M037163


Summaries
for CNTD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for CNTD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNTD2 gene promoter:
         NF-1   GATA-3   NCX/Ncx   HOXA5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNTD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNTD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CNTD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNTD2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M040728:  view genomic region     (about GC identifiers)

Start:
 40,728,115 bp from pter      End:
 40,732,597 bp from pter
Size:
 4,483 bases      Orientation:
 minus strand

Proteins
for CNTD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CNTD2_HUMAN, Q9H8S5 (See protein sequence)
Recommended Name: Cyclin N-terminal domain-containing protein 2  
Size: 307 amino acids; 33574 Da
Secondary accessions: B4DX65
Alternative splicing: 2 isoforms:  Q9H8S5-1   Q9H8S5-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CNTD2: NX_Q9H8S5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H8S5

    • CNTD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079153.2  
    ENSEMBL proteins: 
     ENSP00000396755   ENSP00000221818   ENSP00000425529   ENSP00000408707  

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    Protein Domains /
    Families
    for CNTD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CNTD2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry Q9H8S5

    ProtoNet protein and cluster: Q9H8S5

    UniProtKB/Swiss-Prot: CNTD2_HUMAN, Q9H8S5
    Similarity: Contains 1 cyclin N-terminal domain


    Function
    for CNTD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IEA--


    CNTD2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CNTD2:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 


    Pathways & Interactions
    for CNTD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNTD2

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein kinase activity IEA--


    CNTD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CNTD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CNTD2
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    Transcripts
    for CNTD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CNTD2 gene: 
    NM_024877.3  

    Unigene Cluster for CNTD2:

    Cyclin N-terminal domain containing 2
    Hs.631603  [show with all ESTs]
    Unigene Representative Sequence: NM_024877
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430325(uc010xvi.2) ENST00000221818(uc002ond.3) ENST00000513948
    ENST00000433940

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    hsa-miR-25* hsa-miR-185* hsa-miR-532-3p hsa-miR-3915 hsa-miR-1224-5p hsa-miR-7 hsa-miR-3177-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CNTD2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK023327.1 AK301833.1 

    4 DOTS entries:

    DT.40130977  DT.91796431  DT.121498673  DT.40127694 

    17 AceView cDNA sequences:

    BX280668 BM709160 BX281446 BM767047 BX282037 AU155085 BU732215 NM_024877 
    AK023327 AU133927 AW079378 BG149786 AI924992 CB241999 AA631215 BQ721113 
    AW519020 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CNTD2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:              -     -                                       
    SP2:                                      -                     
    SP3:              -                                             


    ECgene alternative splicing isoforms for CNTD2

    Expression
    for CNTD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNTD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCGCGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CNTD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNTD2

    SOURCE GeneReport for Unigene cluster: Hs.631603
        SABiosciences Custom PCR Arrays for CNTD2
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    In Situ
    Assay Products:     
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    Orthologs
    for CNTD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNTD2 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-132b12.81 si:ch211-132b12.8 49.43(n)
    43.68(a)    		   561391  NM_001044959.1  NP_001038424.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SDS6
    		 cyclin-SDS
    		 9(a)
    		 possible ortholog
    		 1(5079407-5082520)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 cyclin, putative, expressed
    		 12(a)
    		 possible ortholog
    		 3(6555387-6561025)


    ENSEMBL Gene Tree for CNTD2 (if available)
    TreeFam Gene Tree for CNTD2 (if available) 

    Paralogs
    for CNTD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CNTD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/103 NCBI SNPs in CNTD2 are shown (see all 103)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1444179221,2
    		--40727672(+) AGACCG/TCGCCA 1 -- ds50010--------
    rs1812681021,2
    		--40727685(+) GCACTC/TCAGCA 1 -- ds50010--------
    rs1465586821,2
    		C,--40727892(+) TGTGA-/TTTTTT 1 -- ds50010--------
    rs42395041,2
    		C,F,A,H,--40728036(+) CCAATT/CAGAGG 1 -- ds500124Minor allele frequency- C:0.25NS EA NA WA CSA 2352
    rs1849547331,2
    		--40728152(+) GAGACG/TGACAC 1 -- ut310--------
    rs766649201,2
    		F,--40728159(+) ACACAC/GACTGG 1 -- ut311Minor allele frequency- G:0.02EA 120
    rs23041841,2
    		C,F,A,H,--40728417(+) GCAAGG/TGGTTG 1 -- ut31 ese327Minor allele frequency- T:0.27EA NS NA WA CSA 3849
    rs1484055331,2
    		--40728469(+) GAAGCA/GTCGAT 1 -- ut310--------
    rs1424391031,2
    		--40728520(+) GGCACG/TCGTCC 1 -- ut310--------
    rs1513317541,2
    		--40728549(+) CTAGGC/TGAGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CNTD2 (40728115 - 40732597 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CNTD2
         1 CNV: 4080

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    Disorders / Diseases
    for CNTD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for CNTD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNTD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CNTD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    3. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for CNTD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CNTD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79935 HGNC: 25805 AceView: FLJ13265 Ensembl:ENSG00000105219 euGenes: HUgn79935
    ECgene: CNTD2 H-InvDB: CNTD2

    Other Databases showing CNTD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CNTD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNTD2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CNTD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CNTD2 gene:
    Search GeneIP for patents involving CNTD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CNTD2 gene

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    About This Section

     
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