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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNTD2 Gene

protein-coding   GIFtS: 40
GCID: GC19M040728

Cyclin N-Terminal Domain Containing 2

  Search for CNTD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin N-Terminal Domain Containing 21 2
Cyclin N-Terminal Domain-Containing Protein 22

External Ids:    HGNC: 258051   Entrez Gene: 799352   Ensembl: ENSG000001052197   UniProtKB: Q9H8S53   

Export aliases for CNTD2 gene to outside databases

Previous GC identifers: GC19M045420 GC19M037163


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CNTD2 Gene: 
CNTD2 (cyclin N-terminal domain containing 2) is a protein-coding gene. GO annotations related to this gene include protein kinase binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNTD2 gene promoter:
         NF-1   GATA-3   NCX/Ncx   HOXA5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNTD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNTD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNTD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CNTD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNTD2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M040728:  view genomic region     (about GC identifiers)

Start:
40,728,115 bp from pter      End:
40,732,597 bp from pter
Size:
4,483 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNTD2_HUMAN, Q9H8S5 (See protein sequence)
Recommended Name: Cyclin N-terminal domain-containing protein 2  
Size: 307 amino acids; 33574 Da
Secondary accessions: B4DX65
Alternative splicing: 2 isoforms:  Q9H8S5-1   Q9H8S5-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CNTD2: NX_Q9H8S5

Explore proteomics data for CNTD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H8S5

  • CNTD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNTD2 Protein Expression
    REFSEQ proteins: NP_079153.2  
    ENSEMBL proteins: 
     ENSP00000470643   ENSP00000396755   ENSP00000221818   ENSP00000425529   ENSP00000408707  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----

    CNTD2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry Q9H8S5

    ProtoNet protein and cluster: Q9H8S5

    UniProtKB/Swiss-Prot: CNTD2_HUMAN, Q9H8S5
    Similarity: Contains 1 cyclin N-terminal domain


    CNTD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IEA--
         
    CNTD2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CNTD2:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNTD2

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0051726regulation of cell cycle ----

    CNTD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNTD2

    Search CenterWatch for drugs/clinical trials and news about CNTD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CNTD2 gene: 
    NM_024877.3  

    Unigene Cluster for CNTD2:

    Cyclin N-terminal domain containing 2
    Hs.631603  [show with all ESTs]
    Unigene Representative Sequence: NM_024877
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599263 ENST00000430325(uc010xvi.2) ENST00000593335 ENST00000221818(uc002ond.3)
    ENST00000513948 ENST00000433940
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK023327.1 AK301833.1 

    4 DOTS entries:

    DT.40130977  DT.91796431  DT.121498673  DT.40127694 

    17 AceView cDNA sequences:

    BM767047 BM709160 BX281446 BX280668 AI924992 AU133927 AW079378 NM_024877 
    AU155085 BX282037 BU732215 BG149786 CB241999 AK023327 BQ721113 AA631215 
    AW519020 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CNTD2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:              -     -                                       
    SP2:                                      -                     
    SP3:              -                                             


    ECgene alternative splicing isoforms for CNTD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNTD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCGCGCTG
    CNTD2 Expression
    About this image


    See CNTD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNTD2

    SOURCE GeneReport for Unigene cluster: Hs.631603
        SABiosciences Custom PCR Arrays for CNTD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNTD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CNTD2 gene from 2/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia LOC1008567301 cyclin-A2-3-like 84.17(n)
    84.87(a)
      100856730  XM_003638864.1  XP_003638912.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-132b12.81 si:ch211-132b12.8 49.43(n)
    43.68(a)
      561391  NM_001044959.1  NP_001038424.1 


    ENSEMBL Gene Tree for CNTD2 (if available)
    TreeFam Gene Tree for CNTD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNTD2 gene
    3 SIMAP similar genes for CNTD2 using alignment to 3 protein entries:     CNTD2_HUMAN (see all proteins):
    CCNB1    CCNB1V    CCNB2V

    CNTD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/148 SNPs in CNTD2 are shown (see all 148)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444179221,2
    --40727672(+) AGACCG/TCGCCA 1 -- ds50010--------
    rs1812681021,2
    --40727685(+) GCACTC/TCAGCA 1 -- ds50010--------
    rs1465586821,2
    C--40727892(+) TGTGA-/TTTTTT 1 -- ds50010--------
    rs42395041,2
    C,F,A,H--40728036(+) CCAATT/CAGAGG 1 -- ds500124Minor allele frequency- C:0.25NS EA NA WA CSA 2352
    rs1849547331,2
    --40728152(+) GAGACG/TGACAC 1 -- ut310--------
    rs766649201,2
    F--40728159(+) ACACAC/GACTGG 1 -- ut311Minor allele frequency- G:0.02EA 120
    rs23041841,2
    C,F,A,H--40728417(+) GCAAGG/TGGTTG 1 -- ut31 ese327Minor allele frequency- T:0.27EA NS NA WA CSA 3849
    rs1484055331,2
    C--40728469(+) GAAGCA/GTCGAT 1 -- ut310--------
    rs1424391031,2
    --40728520(+) GGCACG/TCGTCC 1 -- ut310--------
    rs1513317541,2
    --40728549(+) CTAGGC/TGAGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CNTD2 (40728115 - 40732597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CNTD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911699CNV Loss21882294
    dgv3865n71CNV Loss21882294
    dgv3866n71CNV Loss21882294
    dgv1083e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNTD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CNTD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    3. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79935 HGNC: 25805 AceView: FLJ13265 Ensembl:ENSG00000105219 euGenes: HUgn79935
    ECgene: CNTD2 H-InvDB: CNTD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNTD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNTD2 gene:
    Search GeneIP for patents involving CNTD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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