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Aliases for CNTD2 Gene

Aliases for CNTD2 Gene

  • Cyclin N-Terminal Domain Containing 2 2 3 5
  • Cyclin P 2 3
  • Cyclin N-Terminal Domain-Containing Protein 2 3
  • CCNP 3

External Ids for CNTD2 Gene

Previous GeneCards Identifiers for CNTD2 Gene

  • GC19M045420
  • GC19M040728
  • GC19M037163

Summaries for CNTD2 Gene

GeneCards Summary for CNTD2 Gene

CNTD2 (Cyclin N-Terminal Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding.

Additional gene information for CNTD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTD2 Gene

Genomics for CNTD2 Gene

Regulatory Elements for CNTD2 Gene

Enhancers for CNTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H040190 1.4 FANTOM5 ENCODE 12.2 +35.9 35868 2.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 ZNF207 ZNF143 ZNF780B NUMBL CYP2G1P SUPT5H EID2B ENSG00000269843 SNRPA PAF1 TTC9B CNTD2
GH19H040089 1.4 ENCODE dbSUPER 10.4 +136.6 136567 2.4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000269843 SNRPA ZNF780A FBL PLEKHG2 ITPKC SUPT5H CYP2G1P PAF1 RN7SL566P
GH19H039940 1.5 FANTOM5 Ensembl ENCODE 9.7 +283.6 283591 6.7 FOXA2 MLX SIN3A DMAP1 SLC30A9 ATF7 RUNX3 NFYC MIER2 PPARG FCGBP ZNF780A PSMC4 SNRPA FBL ENSG00000269843 TTC9B CNTD2 COQ8B ZNF546
GH19H039995 1.4 ENCODE dbSUPER 10 +229.8 229796 2.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF302 ZNF207 SNRPA ENSG00000269843 FBL ZNF780B SUPT5H FCGBP CYP2G1P PAK4 PLEKHG2 EID2B
GH19H040631 1.3 Ensembl ENCODE 9.7 -406.3 -406339 3 ARID4B SIN3A ZNF2 ZNF416 ZNF207 ZNF143 DEK SP3 REST SMARCB1 SNRPA HNRNPUL1 ZNF780B CYP2G1P SERTAD3 CCDC97 CYP2G2P ENSG00000271299 LGALS14 FBL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNTD2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CNTD2 Gene

Genomic Locations for CNTD2 Gene
chr19:40,222,208-40,227,095
(GRCh38/hg38)
Size:
4,888 bases
Orientation:
Minus strand
chr19:40,728,115-40,732,597
(GRCh37/hg19)

Genomic View for CNTD2 Gene

Genes around CNTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTD2 Gene

Proteins for CNTD2 Gene

  • Protein details for CNTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8S5-CNTD2_HUMAN
    Recommended name:
    Cyclin N-terminal domain-containing protein 2
    Protein Accession:
    Q9H8S5
    Secondary Accessions:
    • B4DX65

    Protein attributes for CNTD2 Gene

    Size:
    307 amino acids
    Molecular mass:
    33574 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNTD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNTD2 Gene

Post-translational modifications for CNTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNTD2 Gene

No data available for DME Specific Peptides for CNTD2 Gene

Domains & Families for CNTD2 Gene

Gene Families for CNTD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CNTD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNTD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CNTD2: view

No data available for UniProtKB/Swiss-Prot for CNTD2 Gene

Function for CNTD2 Gene

genes like me logo Genes that share phenotypes with CNTD2: view

miRNA for CNTD2 Gene

miRTarBase miRNAs that target CNTD2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNTD2 Gene

Localization for CNTD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNTD2 gene
Compartment Confidence
mitochondrion 2
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CNTD2 Gene

Pathways & Interactions for CNTD2 Gene

SuperPathways for CNTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNTD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CNTD2 Gene

Drugs & Compounds for CNTD2 Gene

No Compound Related Data Available

Transcripts for CNTD2 Gene

mRNA/cDNA for CNTD2 Gene

Unigene Clusters for CNTD2 Gene

Cyclin N-terminal domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTD2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: -

Relevant External Links for CNTD2 Gene

GeneLoc Exon Structure for
CNTD2
ECgene alternative splicing isoforms for
CNTD2

Expression for CNTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNTD2 Gene

mRNA differential expression in normal tissues according to GTEx for CNTD2 Gene

This gene is overexpressed in Brain - Cerebellum (x10.7), Brain - Cerebellar Hemisphere (x10.0), Kidney - Cortex (x5.5), and Liver (x4.3).

Protein differential expression in normal tissues from HIPED for CNTD2 Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNTD2 Gene



Protein tissue co-expression partners for CNTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNTD2 Gene:

CNTD2

SOURCE GeneReport for Unigene cluster for CNTD2 Gene:

Hs.631603
genes like me logo Genes that share expression patterns with CNTD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNTD2 Gene

Orthologs for CNTD2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CNTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTD2 33 34
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia CNTD2 33 34
  • 82.91 (n)
dog
(Canis familiaris)
Mammalia CNTD2 33 34
  • 78.94 (n)
Species where no ortholog for CNTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CNTD2 Gene

ENSEMBL:
Gene Tree for CNTD2 (if available)
TreeFam:
Gene Tree for CNTD2 (if available)

Paralogs for CNTD2 Gene

(3) SIMAP similar genes for CNTD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CNTD2: view

No data available for Paralogs for CNTD2 Gene

Variants for CNTD2 Gene

Sequence variations from dbSNP and Humsavar for CNTD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000264091 -- 40,223,256(+) GCCTC(A/G)GCCTC nc-transcript-variant, reference, synonymous-codon
rs1000583642 -- 40,228,855(+) TGGTG(A/G)GTGCC upstream-variant-2KB
rs1000668647 -- 40,224,901(+) CTCCA(A/G)TCAGT intron-variant
rs1001276678 -- 40,224,710(+) CCCTT(C/T)CAGAT intron-variant
rs1002570477 -- 40,227,209(+) TGGTG(C/T)CGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CNTD2 Gene

Variant ID Type Subtype PubMed ID
esv3644345 CNV gain 21293372
esv3644344 CNV gain 21293372
esv2758761 CNV gain 17122850

Variation tolerance for CNTD2 Gene

Gene Damage Index Score: 1.33; 26.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTD2 Gene

Disorders for CNTD2 Gene

Relevant External Links for CNTD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNTD2

No disorders were found for CNTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNTD2 Gene

Publications for CNTD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Can sequencing shed light on cell cycling? (PMID: 11237006) Murray AW … Marks D (Nature 2001) 2 3 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 60

Products for CNTD2 Gene

Sources for CNTD2 Gene

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