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Aliases for CNTD1 Gene

Aliases for CNTD1 Gene

  • Cyclin N-Terminal Domain Containing 1 2 3 5
  • CNTD 3 4
  • Cyclin N-Terminal Domain-Containing Protein 1 3
  • Cyclin N-Terminal Domain Containing 2

External Ids for CNTD1 Gene

Previous HGNC Symbols for CNTD1 Gene

  • CNTD

Previous GeneCards Identifiers for CNTD1 Gene

  • GC17P038207
  • GC17P040950
  • GC17P036715

Summaries for CNTD1 Gene

GeneCards Summary for CNTD1 Gene

CNTD1 (Cyclin N-Terminal Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTD1 Gene

Genomics for CNTD1 Gene

Regulatory Elements for CNTD1 Gene

Enhancers for CNTD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G042885 1.5 FANTOM5 Ensembl ENCODE 10.2 +88.0 87952 1.3 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 SP5 MIER2 PPARG CNTD1 COA3 MLX STAT3 EZH1 NBR1 BECN1 RUNDC1 TMEM106A RNU6-287P
GH17G042772 1.2 ENCODE 11.9 -24.3 -24253 4.0 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC LINC00910 CNTNAP1 MEOX1 DHX8 HMGN1P29 CCR10 HMGN2P15 EZH1 ENSG00000267765 CNTD1
GH17G043010 1.6 FANTOM5 ENCODE dbSUPER 8.8 +212.6 212569 2.2 PKNOX1 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 ZNF48 GATA2 FOS NBR2 RUNDC1 PTGES3L-AARSD1 AARSD1 MLX CNTD1 RPL29P31 NBR1 ETV4 TUBG1
GH17G042928 1.3 Ensembl ENCODE 10.8 +130.4 130401 1.8 HDGF FOXA2 ARNT ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 MXD4 G6PC LINC00671 RNU6-287P AOC3 AOC2 CNTD1 COA3 VPS25 RAMP2-AS1 RAMP2
GH17G042823 1.1 ENCODE 12 +25.4 25411 1.7 HDGF MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 COA3 CNTD1 AOC2 AOC3 VPS25 RAMP2-AS1 RAMP2 HMGN2P15 WNK4 AARSD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNTD1 on UCSC Golden Path with GeneCards custom track

Promoters for CNTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094465 -167 601 HDGF MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for CNTD1 Gene

Chromosome:
17
Start:
42,798,667 bp from pter
End:
42,811,587 bp from pter
Size:
12,921 bases
Orientation:
Plus strand

Genomic View for CNTD1 Gene

Genes around CNTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTD1 Gene

Proteins for CNTD1 Gene

  • Protein details for CNTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N815-CNTD1_HUMAN
    Recommended name:
    Cyclin N-terminal domain-containing protein 1
    Protein Accession:
    Q8N815
    Secondary Accessions:
    • Q658Q6
    • Q8NEP1

    Protein attributes for CNTD1 Gene

    Size:
    330 amino acids
    Molecular mass:
    36921 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNTD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNTD1 Gene

Post-translational modifications for CNTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CNTD1 Gene

Domains & Families for CNTD1 Gene

Protein Domains for CNTD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNTD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CNTD1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CNTD1 Gene

Function for CNTD1 Gene

Phenotypes for CNTD1 Gene

genes like me logo Genes that share phenotypes with CNTD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CNTD1 Gene

Localization for CNTD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNTD1 gene
Compartment Confidence
plasma membrane 3
nucleus 2
extracellular 1
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CNTD1 Gene

Pathways & Interactions for CNTD1 Gene

SuperPathways for CNTD1 Gene

No Data Available

Interacting Proteins for CNTD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000465204%0d%0a9606.ENSP00000263388%0d%0a
Selected Interacting proteins: Q8N815-CNTD1_HUMAN ENSP00000465204 for CNTD1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CNTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007131 reciprocal meiotic recombination IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with CNTD1: view

No data available for Pathways by source and SIGNOR curated interactions for CNTD1 Gene

Drugs & Compounds for CNTD1 Gene

No Compound Related Data Available

Transcripts for CNTD1 Gene

Unigene Clusters for CNTD1 Gene

Cyclin N-terminal domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for CNTD1 Gene

GeneLoc Exon Structure for
CNTD1
ECgene alternative splicing isoforms for
CNTD1

Expression for CNTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTD1 Gene

This gene is overexpressed in Testis (x33.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNTD1 Gene



Protein tissue co-expression partners for CNTD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNTD1 Gene:

CNTD1

SOURCE GeneReport for Unigene cluster for CNTD1 Gene:

Hs.12272

Evidence on tissue expression from TISSUES for CNTD1 Gene

  • Stomach(4.1)
genes like me logo Genes that share expression patterns with CNTD1: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNTD1 Gene

Orthologs for CNTD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTD1 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia CNTD1 34 35
  • 88.62 (n)
dog
(Canis familiaris)
Mammalia CNTD1 34
  • 88.55 (n)
mouse
(Mus musculus)
Mammalia Cntd1 34 16 35
  • 85.71 (n)
rat
(Rattus norvegicus)
Mammalia Cntd1 34
  • 85.02 (n)
oppossum
(Monodelphis domestica)
Mammalia CNTD1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNTD1 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNTD1 34
  • 62.81 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cntd1 34
  • 56.07 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100150347 34
  • 52.6 (n)
CNTD1 35
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cosa-1 35
  • 19 (a)
OneToOne
Species where no ortholog for CNTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNTD1 Gene

ENSEMBL:
Gene Tree for CNTD1 (if available)
TreeFam:
Gene Tree for CNTD1 (if available)

Paralogs for CNTD1 Gene

(1) SIMAP similar genes for CNTD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CNTD1: view

No data available for Paralogs for CNTD1 Gene

Variants for CNTD1 Gene

Sequence variations from dbSNP and Humsavar for CNTD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs139877390 Pathogenic 42,798,167(+) AACCA(C/T)CTGGG upstream-variant-2KB, reference, missense
rs757472611 Pathogenic 42,798,482(+) CACCA(-/G)GGGCC upstream-variant-2KB, reference, frameshift-variant
rs61755635 Likely benign 42,796,694(+) ATTCA(A/G)AACAG upstream-variant-2KB, reference, missense, utr-variant-3-prime
rs61755636 Likely benign 42,797,023(+) ATGCT(C/G/T)ACACC downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs886052954 Uncertain significance 42,797,028(+) CACAC(A/C)ACATT downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CNTD1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv833450 CNV loss 17160897

Variation tolerance for CNTD1 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.44; 90.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTD1 Gene

Disorders for CNTD1 Gene

Relevant External Links for CNTD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNTD1

No disorders were found for CNTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNTD1 Gene

Publications for CNTD1 Gene

  1. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. (PMID: 24891606) Holloway J.K. … Cohen P.E. (J. Cell Biol. 2014) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for CNTD1 Gene

Sources for CNTD1 Gene

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