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Aliases for CNTD1 Gene

Aliases for CNTD1 Gene

  • Cyclin N-Terminal Domain Containing 1 2 3 5
  • CNTD 3 4
  • Cyclin N-Terminal Domain-Containing Protein 1 3
  • Cyclin N-Terminal Domain Containing 2

External Ids for CNTD1 Gene

Previous HGNC Symbols for CNTD1 Gene

  • CNTD

Previous GeneCards Identifiers for CNTD1 Gene

  • GC17P038207
  • GC17P040950
  • GC17P036715

Summaries for CNTD1 Gene

GeneCards Summary for CNTD1 Gene

CNTD1 (Cyclin N-Terminal Domain Containing 1) is a Protein Coding gene.

Additional gene information for CNTD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTD1 Gene

Genomics for CNTD1 Gene

GeneHancer (GH) Regulatory Elements for CNTD1 Gene

Promoters and enhancers for CNTD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I042796 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.7 -727 2.8 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 COA3 CNTD1 ENSG00000267340 PLEKHH3 NKIRAS2 MEOX1 HMGN2P15 RAMP2-AS1 ENSG00000267765 PTP4A2P1
GH17I043322 Enhancer 1.5 Ensembl ENCODE dbSUPER 33.7 +524.5 524496 1.6 CLOCK MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 ENSG00000267340 UBTF ASB16-AS1 ENSG00000267002 DHX8 HMGN1P29 TMUB2 NBR2 LINC00910 PLEKHH3
GH17I042576 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.3 -220.5 -220483 4.2 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 PSMC3IP GC17P042580 GC17P042577 DHX8 HMGN1P29 ENSG00000267758 TUBG2 NBR2 MLX STAT5A
GH17I042419 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.6 -376.7 -376723 5.2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B CAVIN1 LOC102725238 LINC00910 HMGN1P29 NBR2 ENSG00000267758 DHX58 PSME3 CNTD1 RETREG3
GH17I041810 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 15.6 -985.9 -985855 4.4 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF213 ZNF302 ZNF207 P3H4 FKBP10 PIR33798 DHX58 NT5C3B CNTD1 CAVIN1 RETREG3 KAT2A HSD17B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CNTD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CNTD1 gene promoter:

Genomic Locations for CNTD1 Gene

Genomic Locations for CNTD1 Gene
12,921 bases
Plus strand

Genomic View for CNTD1 Gene

Genes around CNTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTD1 Gene

Proteins for CNTD1 Gene

  • Protein details for CNTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin N-terminal domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q658Q6
    • Q8NEP1

    Protein attributes for CNTD1 Gene

    330 amino acids
    Molecular mass:
    36921 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNTD1 Gene


neXtProt entry for CNTD1 Gene

Post-translational modifications for CNTD1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CNTD1 Gene

Domains & Families for CNTD1 Gene

Gene Families for CNTD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CNTD1 Gene


Suggested Antigen Peptide Sequences for CNTD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CNTD1: view

No data available for UniProtKB/Swiss-Prot for CNTD1 Gene

Function for CNTD1 Gene

Phenotypes From GWAS Catalog for CNTD1 Gene

Phenotypes for CNTD1 Gene

genes like me logo Genes that share phenotypes with CNTD1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CNTD1 Gene

Localization for CNTD1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNTD1 gene
Compartment Confidence
plasma membrane 3
nucleus 2
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (1)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CNTD1 Gene

Pathways & Interactions for CNTD1 Gene

SuperPathways for CNTD1 Gene

No Data Available

Interacting Proteins for CNTD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8N815-CNTD1_HUMAN ENSP00000465204 for CNTD1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CNTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007131 reciprocal meiotic recombination IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with CNTD1: view

No data available for Pathways by source and SIGNOR curated interactions for CNTD1 Gene

Drugs & Compounds for CNTD1 Gene

No Compound Related Data Available

Transcripts for CNTD1 Gene

Unigene Clusters for CNTD1 Gene

Cyclin N-terminal domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP2: -

Relevant External Links for CNTD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTD1 Gene

This gene is overexpressed in Testis (x33.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNTD1 Gene

Protein tissue co-expression partners for CNTD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNTD1 Gene:


SOURCE GeneReport for Unigene cluster for CNTD1 Gene:


Evidence on tissue expression from TISSUES for CNTD1 Gene

  • Stomach(4.1)
genes like me logo Genes that share expression patterns with CNTD1: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNTD1 Gene

Orthologs for CNTD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNTD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNTD1 33 34
  • 99.29 (n)
(Bos Taurus)
Mammalia CNTD1 33 34
  • 88.62 (n)
(Canis familiaris)
Mammalia CNTD1 33
  • 88.55 (n)
(Mus musculus)
Mammalia Cntd1 33 16 34
  • 85.71 (n)
(Rattus norvegicus)
Mammalia Cntd1 33
  • 85.02 (n)
(Monodelphis domestica)
Mammalia CNTD1 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia CNTD1 34
  • 64 (a)
(Gallus gallus)
Aves CNTD1 33
  • 62.81 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cntd1 33
  • 56.07 (n)
(Danio rerio)
Actinopterygii LOC100150347 33
  • 52.6 (n)
CNTD1 34
  • 43 (a)
(Caenorhabditis elegans)
Secernentea cosa-1 34
  • 19 (a)
Species where no ortholog for CNTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNTD1 Gene

Gene Tree for CNTD1 (if available)
Gene Tree for CNTD1 (if available)

Paralogs for CNTD1 Gene

(1) SIMAP similar genes for CNTD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CNTD1: view

No data available for Paralogs for CNTD1 Gene

Variants for CNTD1 Gene

Sequence variations from dbSNP and Humsavar for CNTD1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs139877390 pathogenic, Cytochrome-c oxidase deficiency 42,798,167(+) T/C upstream_transcript_variant
rs61755635 likely-benign, Pseudohypoaldosteronism, type 2 42,796,694(+) G/A upstream_transcript_variant
rs61755636 likely-benign, Pseudohypoaldosteronism, type 2 42,797,023(+) C/G/T upstream_transcript_variant
rs757472611 pathogenic, Cytochrome-c oxidase deficiency 42,798,483(+) GGG/GGGG upstream_transcript_variant
rs886052954 uncertain-significance, Pseudohypoaldosteronism, type 2 42,797,028(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CNTD1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv833450 CNV loss 17160897

Variation tolerance for CNTD1 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.44; 90.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CNTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTD1 Gene

Disorders for CNTD1 Gene

Additional Disease Information for CNTD1

No disorders were found for CNTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNTD1 Gene

Publications for CNTD1 Gene

  1. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. (PMID: 24891606) Holloway JK … Cohen PE (The Journal of cell biology 2014) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung JG … Wang TL (PLoS genetics 2014) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for CNTD1 Gene

Sources for CNTD1 Gene

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