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Aliases for CNTD1 Gene

Aliases for CNTD1 Gene

  • Cyclin N-Terminal Domain Containing 1 2 3
  • CNTD 3 4
  • Cyclin N-Terminal Domain-Containing Protein 1 3
  • Cyclin N-Terminal Domain Containing 2

External Ids for CNTD1 Gene

Previous HGNC Symbols for CNTD1 Gene

  • CNTD

Previous GeneCards Identifiers for CNTD1 Gene

  • GC17P038207
  • GC17P040950
  • GC17P036715

Summaries for CNTD1 Gene

GeneCards Summary for CNTD1 Gene

CNTD1 (Cyclin N-Terminal Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTD1 Gene

Genomics for CNTD1 Gene

Regulatory Elements for CNTD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNTD1 Gene

Start:
42,798,675 bp from pter
End:
42,811,587 bp from pter
Size:
12,913 bases
Orientation:
Plus strand

Genomic View for CNTD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTD1 Gene

Proteins for CNTD1 Gene

  • Protein details for CNTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N815-CNTD1_HUMAN
    Recommended name:
    Cyclin N-terminal domain-containing protein 1
    Protein Accession:
    Q8N815
    Secondary Accessions:
    • Q658Q6
    • Q8NEP1

    Protein attributes for CNTD1 Gene

    Size:
    330 amino acids
    Molecular mass:
    36921 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNTD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNTD1 Gene

Proteomics data for CNTD1 Gene at MOPED

Post-translational modifications for CNTD1 Gene

No Post-translational modifications

Other Protein References for CNTD1 Gene

No data available for DME Specific Peptides for CNTD1 Gene

Domains for CNTD1 Gene

Protein Domains for CNTD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNTD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N815

UniProtKB/Swiss-Prot:

CNTD1_HUMAN :
  • Q8N815
Domain:
  • Contains 1 cyclin N-terminal domain.
genes like me logo Genes that share domains with CNTD1: view

No data available for Gene Families for CNTD1 Gene

Function for CNTD1 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNTD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CNTD1 Gene

Localization for CNTD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNTD1 Gene COMPARTMENTS Subcellular localization image for CNTD1 gene
Compartment Confidence
cytosol 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CNTD1 Gene

Pathways for CNTD1 Gene

SuperPathways for CNTD1 Gene

No Data Available

Interacting Proteins for CNTD1 Gene

Gene Ontology (GO) - Biological Process for CNTD1 Gene

None

No data available for Pathways by source for CNTD1 Gene

Transcripts for CNTD1 Gene

Unigene Clusters for CNTD1 Gene

Cyclin N-terminal domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNTD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for CNTD1 Gene

GeneLoc Exon Structure for
CNTD1
ECgene alternative splicing isoforms for
CNTD1

Expression for CNTD1 Gene

mRNA expression in normal human tissues for CNTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNTD1 Gene

This gene is overexpressed in Testis (33.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CNTD1 Gene

SOURCE GeneReport for Unigene cluster for CNTD1 Gene Hs.12272

genes like me logo Genes that share expressions with CNTD1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CNTD1 Gene

Orthologs for CNTD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNTD1 35
  • 99.29 (n)
  • 98.79 (a)
CNTD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNTD1 35
  • 88.62 (n)
  • 85.06 (a)
CNTD1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNTD1 35
  • 88.55 (n)
  • 86.02 (a)
mouse
(Mus musculus)
Mammalia Cntd1 35
  • 85.71 (n)
  • 85.41 (a)
Cntd1 16
Cntd1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNTD1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNTD1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cntd1 35
  • 85.02 (n)
  • 85.93 (a)
chicken
(Gallus gallus)
Aves CNTD1 35
  • 62.81 (n)
  • 56.46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cntd1 35
  • 56.07 (n)
  • 45.7 (a)
zebrafish
(Danio rerio)
Actinopterygii CNTD1 36
  • 43 (a)
OneToOne
LOC100150347 35
  • 52.6 (n)
  • 46.84 (a)
worm
(Caenorhabditis elegans)
Secernentea cosa-1 36
  • 19 (a)
OneToOne
Species with no ortholog for CNTD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNTD1 Gene

ENSEMBL:
Gene Tree for CNTD1 (if available)
TreeFam:
Gene Tree for CNTD1 (if available)

Paralogs for CNTD1 Gene

Selected SIMAP similar genes for CNTD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CNTD1: view

No data available for Paralogs for CNTD1 Gene

Variants for CNTD1 Gene

Sequence variations from dbSNP and Humsavar for CNTD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1011157 -- 42,808,235(-) ACAAG(A/G)TCTTG intron-variant
rs3178451 -- 42,806,803(+) CACTC(A/C)CAGTC missense, reference
rs9906075 -- 42,805,368(+) tataa(A/C)tgtac intron-variant
rs12947820 - 42,805,737(+) ACATT(A/C)CAGTC reference, missense
rs16968007 -- 42,805,685(+) TTTAT(C/G)CTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNTD1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv833450 CNV Loss 17160897

Relevant External Links for CNTD1 Gene

HapMap Linkage Disequilibrium report
CNTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNTD1 Gene

Disorders for CNTD1 Gene

No disorders were found for CNTD1 Gene.

No data available for UniProtKB/Swiss-Prot for CNTD1 Gene

Publications for CNTD1 Gene

  1. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. (PMID: 24891606) Holloway J.K. … Cohen P.E. (J. Cell Biol. 2014) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3

Products for CNTD1 Gene

Sources for CNTD1 Gene

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