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Aliases for CNST Gene

Aliases for CNST Gene

  • Consortin, Connexin Sorting Protein 2 3 5
  • C1orf71 3 4
  • Protein Phosphatase 1, Regulatory Subunit 64 3
  • Chromosome 1 Open Reading Frame 71 2
  • Protein Phosphatase 1 2
  • Regulatory Subunit 64 2
  • PPP1R64 3

External Ids for CNST Gene

Previous HGNC Symbols for CNST Gene

  • C1orf71

Previous GeneCards Identifiers for CNST Gene

  • GC01P244797
  • GC01P246730
  • GC01P217115

Summaries for CNST Gene

Entrez Gene Summary for CNST Gene

  • Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]

GeneCards Summary for CNST Gene

CNST (Consortin, Connexin Sorting Protein) is a Protein Coding gene. Diseases associated with CNST include Spinal Cord Lymphoma. GO annotations related to this gene include phosphatase binding and connexin binding.

UniProtKB/Swiss-Prot for CNST Gene

  • Required for targeting of connexins to the plasma membrane.

Gene Wiki entry for CNST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNST Gene

Genomics for CNST Gene

Regulatory Elements for CNST Gene

Enhancers for CNST Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CNST on UCSC Golden Path with GeneCards custom track

Promoters for CNST Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNST on UCSC Golden Path with GeneCards custom track

Genomic Location for CNST Gene

246,566,337 bp from pter
246,668,587 bp from pter
102,251 bases
Plus strand

Genomic View for CNST Gene

Genes around CNST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNST Gene

Proteins for CNST Gene

  • Protein details for CNST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5VSY9
    • Q5VTM7
    • Q8IYA9
    • Q8N3L5
    • Q8NB09
    • Q8TEI2
    • Q96MR5

    Protein attributes for CNST Gene

    725 amino acids
    Molecular mass:
    79597 Da
    Quaternary structure:
    • Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interacts with GGA1 and GGA2. Does not interact with PANX1 (By similarity).
    • Sequence=BAB84968.1; Type=Frameshift; Positions=237; Evidence={ECO:0000305}; Sequence=BAC03735.1; Type=Frameshift; Positions=412; Evidence={ECO:0000305}; Sequence=CAD38922.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CNST Gene


neXtProt entry for CNST Gene

Proteomics data for CNST Gene at MOPED

Post-translational modifications for CNST Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNST Gene

No data available for DME Specific Peptides for CNST Gene

Domains & Families for CNST Gene

Gene Families for CNST Gene

Protein Domains for CNST Gene


Suggested Antigen Peptide Sequences for CNST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CNST family.
  • Belongs to the CNST family.
genes like me logo Genes that share domains with CNST: view

Function for CNST Gene

Molecular function for CNST Gene

UniProtKB/Swiss-Prot Function:
Required for targeting of connexins to the plasma membrane.
genes like me logo Genes that share phenotypes with CNST: view

Animal Model Products

miRNA for CNST Gene

miRTarBase miRNAs that target CNST

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNST Gene

Localization for CNST Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNST Gene

Cell membrane; Single-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway.

Subcellular locations from

Jensen Localization Image for CNST Gene COMPARTMENTS Subcellular localization image for CNST gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CNST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IDA 19864490
GO:0005886 plasma membrane IDA 19864490
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNST: view

Pathways & Interactions for CNST Gene

SuperPathways for CNST Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNST Gene


No data available for Pathways by source and SIGNOR curated interactions for CNST Gene

Drugs & Compounds for CNST Gene

No Compound Related Data Available

Transcripts for CNST Gene

Unigene Clusters for CNST Gene

Consortin, connexin sorting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNST Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -

Relevant External Links for CNST Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNST Gene

mRNA expression in normal human tissues for CNST Gene

Protein differential expression in normal tissues from HIPED for CNST Gene

This gene is overexpressed in Platelet (26.1), Peripheral blood mononuclear cells (23.4), and Testis (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNST Gene

SOURCE GeneReport for Unigene cluster for CNST Gene Hs.368353

genes like me logo Genes that share expression patterns with CNST: view

Protein tissue co-expression partners for CNST Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNST Gene

Orthologs for CNST Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNST Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNST 35
  • 87.47 (n)
  • 82.39 (a)
  • 82 (a)
(Canis familiaris)
Mammalia CNST 35
  • 80.89 (n)
  • 75.35 (a)
  • 75 (a)
(Mus musculus)
Mammalia Cnst 35
  • 76.26 (n)
  • 69.82 (a)
Cnst 16
Cnst 36
  • 69 (a)
(Pan troglodytes)
Mammalia CNST 35
  • 96.29 (n)
  • 95.13 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Cnst 35
  • 77.04 (n)
  • 70.44 (a)
(Monodelphis domestica)
Mammalia CNST 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia CNST 36
  • 55 (a)
(Gallus gallus)
Aves CNST 35
  • 62.79 (n)
  • 48.39 (a)
  • 41 (a)
(Anolis carolinensis)
Reptilia CNST 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnst 35
  • 55.47 (n)
  • 44.01 (a)
(Danio rerio)
Actinopterygii cnsta 36
  • 30 (a)
cnstb 36
  • 36 (a)
Species with no ortholog for CNST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNST Gene

Gene Tree for CNST (if available)
Gene Tree for CNST (if available)

Paralogs for CNST Gene

No data available for Paralogs for CNST Gene

Variants for CNST Gene

Sequence variations from dbSNP and Humsavar for CNST Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_032530 -
VAR_032531 -
rs12075111 - 246,647,396(+) ACAGT(C/T)GCTTG reference, missense
rs12091148 - 246,621,597(+) TGAGC(A/G)GTTGG intron-variant, reference, missense
rs8344 -- 246,668,054(-) GAGCT(C/T)ACCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CNST Gene

Variant ID Type Subtype PubMed ID
dgv202e1 CNV Complex 17122850
nsv428346 CNV Gain 18775914
dgv33n21 CNV Gain 19592680
nsv873420 CNV Gain 21882294
nsv528615 CNV Gain 19592680
nsv5254 CNV Insertion 18451855
esv2499098 CNV Insertion 19546169
nsv9047 CNV Loss 18304495
esv1262343 CNV Insertion 17803354
esv26600 CNV Loss 19812545
esv2727496 CNV Deletion 23290073
nsv509746 CNV Insertion 20534489
esv2727507 CNV Deletion 23290073
esv2621871 CNV Insertion 19546169
esv2667587 CNV Deletion 23128226
esv1713139 CNV Insertion 17803354
nsv873421 CNV Gain 21882294
nsv509757 CNV Insertion 20534489

Variation tolerance for CNST Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CNST Gene

Disorders for CNST Gene

MalaCards: The human disease database

(1) MalaCards diseases for CNST Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinal cord lymphoma
  • lymphoma of the spinal cord
- elite association - COSMIC cancer census association via MalaCards
Search CNST in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNST

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CNST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNST Gene

Publications for CNST Gene

  1. Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. (PMID: 19864490) del Castillo F.J. … Petit C. (Hum. Mol. Genet. 2010) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for CNST Gene

Sources for CNST Gene