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Aliases for CNST Gene

Aliases for CNST Gene

  • Consortin, Connexin Sorting Protein 2 3
  • C1orf71 3 4
  • Protein Phosphatase 1, Regulatory Subunit 64 3
  • Chromosome 1 Open Reading Frame 71 2
  • Protein Phosphatase 1 2
  • Regulatory Subunit 64 2
  • Consortin 3
  • PPP1R64 3

External Ids for CNST Gene

Previous Symbols for CNST Gene

  • C1orf71

Summaries for CNST Gene

Entrez Gene Summary for CNST Gene

  • Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]

GeneCards Summary for CNST Gene

CNST (Consortin, Connexin Sorting Protein) is a Protein Coding gene. GO annotations related to this gene include phosphatase binding and connexin binding.

UniProtKB/Swiss-Prot for CNST Gene

  • Required for targeting of connexins to the plasma membrane.

Gene Wiki entry for CNST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNST Gene

Genomics for CNST Gene

Genomic Location for CNST Gene

Start:
246,566,337 bp from pter
End:
246,668,584 bp from pter
Size:
102,248 bases
Orientation:
Plus strand

Genomic View for CNST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNST Gene

No data available for Regulatory Elements for CNST Gene

Proteins for CNST Gene

  • Protein details for CNST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJW8-CNST_HUMAN
    Recommended name:
    Consortin
    Protein Accession:
    Q6PJW8
    Secondary Accessions:
    • Q5VSY9
    • Q5VTM7
    • Q8IYA9
    • Q8N3L5
    • Q8NB09
    • Q8TEI2
    • Q96MR5

    Protein attributes for CNST Gene

    Size:
    725 amino acids
    Molecular mass:
    79597 Da
    Quaternary structure:
    • Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interacts with GGA1 and GGA2. Does not interact with PANX1 (By similarity).
    SequenceCaution:
    • Sequence=BAB84968.1; Type=Frameshift; Positions=237; Evidence={ECO:0000305}; Sequence=BAC03735.1; Type=Frameshift; Positions=412; Evidence={ECO:0000305}; Sequence=CAD38922.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CNST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNST Gene

Proteomics data for CNST Gene at MOPED

Post-translational modifications for CNST Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn226

Other Protein References for CNST Gene

No data available for DME Specific Peptides for CNST Gene

Domains for CNST Gene

Gene Families for CNST Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for CNST Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CNST_HUMAN
Family:
  • Belongs to the CNST family.:
    • Q6PJW8
genes like me logo Genes that share domains with CNST: view

Function for CNST Gene

Molecular function for CNST Gene

UniProtKB/Swiss-Prot Function: Required for targeting of connexins to the plasma membrane.

Gene Ontology (GO) - Molecular Function for CNST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19389623
GO:0019902 phosphatase binding IDA 19389623
GO:0071253 connexin binding ISS --
genes like me logo Genes that share ontologies with CNST: view

Phenotypes for CNST Gene

GenomeRNAi human phenotypes for CNST:
genes like me logo Genes that share phenotypes with CNST: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CNST Gene

Localization for CNST Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNST Gene

Cell membrane; Single-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNST Gene COMPARTMENTS Subcellular localization image for CNST gene
Compartment Confidence
plasma membrane 5
golgi apparatus 3
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CNST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IDA 19864490
GO:0005886 plasma membrane IDA 19864490
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA 19864490
genes like me logo Genes that share ontologies with CNST: view

Pathways for CNST Gene

SuperPathways for CNST Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0042998 positive regulation of Golgi to plasma membrane protein transport IMP 19864490
genes like me logo Genes that share ontologies with CNST: view

No data available for Pathways by source for CNST Gene

Transcripts for CNST Gene

Unigene Clusters for CNST Gene

Consortin, connexin sorting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNST Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for CNST Gene

GeneLoc Exon Structure for
CNST
ECgene alternative splicing isoforms for
CNST

Expression for CNST Gene

mRNA expression in normal human tissues for CNST Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNST Gene

SOURCE GeneReport for Unigene cluster for CNST Gene Hs.368353

genes like me logo Genes that share expressions with CNST: view

Orthologs for CNST Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNST 36
  • 96.29 (n)
  • 95.13 (a)
CNST 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNST 36
  • 87.47 (n)
  • 82.39 (a)
CNST 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNST 36
  • 80.89 (n)
  • 75.35 (a)
CNST 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnst 36
  • 76.26 (n)
  • 69.82 (a)
Cnst 16
Cnst 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNST 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNST 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnst 36
  • 77.04 (n)
  • 70.44 (a)
chicken
(Gallus gallus)
Aves CNST 36
  • 62.79 (n)
  • 48.39 (a)
CNST 37
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNST 37
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnst 36
  • 55.47 (n)
  • 44.01 (a)
zebrafish
(Danio rerio)
Actinopterygii cnsta 37
  • 30 (a)
OneToMany
cnstb 37
  • 36 (a)
OneToMany
Species with no ortholog for CNST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNST Gene

ENSEMBL:
Gene Tree for CNST (if available)
TreeFam:
Gene Tree for CNST (if available)

Paralogs for CNST Gene

No data available for Paralogs for CNST Gene

Variants for CNST Gene

Sequence variations from dbSNP and Humsavar for CNST Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8344 -- 246,668,054(-) GAGCT(C/T)ACCTC utr-variant-3-prime
rs10151 -- 246,666,715(-) CATCC(A/G)TGACA utr-variant-3-prime
rs1134480 -- 246,636,849(+) TGACA(A/T)GAGTA intron-variant
rs1135644 -- 246,666,440(+) GTGTT(C/T)GCGTG utr-variant-3-prime
rs1135650 -- 246,667,099(+) AAGCC(A/T)TGCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CNST Gene

Variant ID Type Subtype PubMed ID
dgv202e1 CNV Complex 17122850
nsv428346 CNV Gain 18775914
dgv33n21 CNV Gain 19592680
nsv873420 CNV Gain 21882294
nsv528615 CNV Gain 19592680
nsv5254 CNV Insertion 18451855
esv2499098 CNV Insertion 19546169
nsv9047 CNV Loss 18304495
esv1262343 CNV Insertion 17803354
esv26600 CNV Loss 19812545
esv2727496 CNV Deletion 23290073
nsv509746 CNV Insertion 20534489
esv2727507 CNV Deletion 23290073
esv2621871 CNV Insertion 19546169
esv2667587 CNV Deletion 23128226
esv1713139 CNV Insertion 17803354
nsv873421 CNV Gain 21882294
nsv509757 CNV Insertion 20534489

Relevant External Links for CNST Gene

HapMap Linkage Disequilibrium report
CNST

Disorders for CNST Gene

No disorders were found for CNST Gene.

No data available for UniProtKB/Swiss-Prot for CNST Gene

Publications for CNST Gene

  1. Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. (PMID: 19864490) del Castillo F.J. … Petit C. (Hum. Mol. Genet. 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CNST Gene

Sources for CNST Gene

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