CNST Gene
protein-coding GIFtS: 45
GCID: GC01P246730
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consortin, connexin sorting protein(Previous name: chromosome 1 open reading frame 71 )
(Previous symbol: C1orf71)
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Aliases
for CNST gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Consortin, Connexin Sorting Protein1 2 | | Chromosome 1 Open Reading Frame 711 | | C1orf711 2 3 | | Consortin1 | | PPP1R641 2 | | Protein Phosphatase 1, Regulatory Subunit 642 | | FLJ320011 | | |
Export aliases for CNST gene to outside databasesPrevious GC identifers: GC01P244797 GC01P217115 |
Summaries
for CNST gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CNST:
Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargoreceptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex.Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks ofgap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membraneand recycling from the cell surface (del Castillo et al., 2010 (PubMed 19864490)).(supplied by OMIM, Jun 2010)
UniProtKB/Swiss-Prot: CNST_HUMAN, Q6PJW8Function: Required for targeting of connexins to the plasma membrane
Gene Wiki entry for CNST (C1orf71)
|
Genomic Views
for CNST gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CNST
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNST
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNST |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44CNST Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P246730: view genomic region
(about GC identifiers)
Start:
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246,729,639 bp from pter |
End:
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246,831,886 bp from pter |
Size:
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102,248 bases |
Orientation:
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plus strand |
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Proteins
for CNST gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CNST_HUMAN, Q6PJW8 (See
protein sequence)Recommended Name: Consortin Size: 725 amino acids; 79597 Da
Subunit: Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interactswith GGA1 and GGA2. Does not interact with PANX1 (By similarity)
Subcellular location: Cell membrane; Single-pass membrane protein. Golgi apparatus, trans-Golgi network membrane;Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Located predominantly in the trans-Golginetwork. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway
Sequence caution: Sequence=BAB84968.1; Type=Frameshift; Positions=237; Sequence=BAC03735.1; Type=Frameshift;Positions=412; Sequence=CAD38922.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5VSY9 Q5VTM7 Q8IYA9 Q8N3L5 Q8NB09 Q8TEI2 Q96MR5Alternative splicing: 3 isoforms: Q6PJW8-1 Q6PJW8-2 Q6PJW8-3 Explore the universe of human proteins at neXtProt for CNST: NX_Q6PJW8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PJW8
CNST Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001132931.1 NP_689822.2
ENSEMBL proteins: ENSP00000355470 ENSP00000355469 ENSP00000355468
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CNST for ontologies About GeneDecksing
CNST Antibody Products:
Assay Products for CNST: |
Protein
Domains /
Families
for CNST gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6PJW8 UniProtKB/Swiss-Prot: CNST_HUMAN, Q6PJW8Similarity: Belongs to the CNST family |
Function
for CNST gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CNST_HUMAN, Q6PJW8Function: Required for targeting of connexins to the plasma membrane
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNST (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNST (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CNST (NM_001139459) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNST | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNST |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNST |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CNST for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CNST:
|
Pathways & Interactions
for CNST gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNST
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/19 Interacting proteins for CNST (Q6PJW81, 3 ENSP000003554704) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010923 | negative regulation of phosphatase activity |
IDA | 19389623 | | GO:0042998 | positive regulation of Golgi to plasma membrane protein transport |
IMP | 19864490 |
CNST for ontologies About GeneDecksing
|
Drugs & Compounds
for CNST gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CNST
Search CenterWatch for drugs/clinical trials and news about CNST
|
Transcripts
for CNST gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CNST gene (2 alternative transcripts): NM_001139459.1 NM_152609.2 Unigene Cluster for CNST: Consortin, connexin sorting protein Hs.368353 [show with all ESTs]Unigene Representative Sequence: NM_1526094 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000483271 ENST00000366513(uc001ibp.3) ENST00000366512(uc001ibo.4)
ENST00000366511
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNST (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNST (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CNST (NM_001139459) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNST | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNST |
Additional cDNA sequence: AK026365.1 AK056563.1 AK074142.1 AK091739.1 AL834246.2 BC010228.2 BX647629.1 11 DOTS entries: DT.80101737 DT.100802078 DT.40130945 DT.92424112 DT.100651172 DT.121423586 DT.97842752 DT.100026544 DT.100774993 DT.101983157 DT.40126326 24/187 AceView cDNA sequences (see all 187): AW136406 AI140160 AI139381 AA910991 AI080173 AA830273 BI820961 CB118846 AI288579 AA456406 F01914 AK056563 BQ434752 AW589445 NM_152609 BC010228 BQ777268 BC036200 AI147814 AI192176 Z44874 AW193863 AI085936 CR601354
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CNST (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 |
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| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CNST
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Expression
for CNST gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNST expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAATTCAT
About this image
See CNST Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNST
SOURCE GeneReport for Unigene cluster: Hs.368353
SABiosciences Custom PCR Arrays for CNST
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNST
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNST | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNST | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNST | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNST |
Orthologs
for CNST gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CNST gene from 5/11 species (see all 11) About this table
ENSEMBL Gene Tree for CNST (if available)
TreeFam Gene Tree for CNST (if available) |
Paralogs
for CNST gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CNST gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CNST (246729639 - 246831886 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for CNST
4 CNVs: 31699 3338 84969 66416
4 Indels: 97712 39707 84970 97711 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNST |
|
Disorders
/ Diseases
for CNST gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CNST for disorders About GeneDecksing
OMIM gene information: 613439
OMIM disorders: --
4  diseases for CNST: About MalaCardsspinal cord lymphoma spinal cancer toxoplasmosis cerebritis
Export disorders for CNST gene to outside databases
|
Publications
for CNST gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CNST gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with CNST) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. (PubMed id 19864490)1, 2, 3 del Castillo F.J.... Petit C. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1 Hendrickx A.... Bollen M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for CNST gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CNST gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CNST gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CNST gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CNST | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CNST gene:
Search GeneIP for patents involving CNST
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CNST gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CNST | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNST | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNST | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for CNST | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNST | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNST | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CNST | | OriGene Custom Protein Services for CNST | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNST | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNST | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNST | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNST | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNST | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNST |
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 |  |  |  | |
| | | | Search Tocris compounds for CNST |
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 | | | CNST Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNST |
|  |  |  | | | | Search ThermoFisher Antibodies for CNST |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNST |
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