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Aliases for CNRIP1 Gene

Aliases for CNRIP1 Gene

  • Cannabinoid Receptor Interacting Protein 1 2 3 5
  • C2orf32 3 4
  • CRIP-1 3 4
  • CB1 Cannabinoid Receptor-Interacting Protein 1 3
  • Cannabinoid Receptor CB1-Interacting Protein 1 3
  • Chromosome 2 Open Reading Frame 32 2
  • CRIP1 3

External Ids for CNRIP1 Gene

Previous HGNC Symbols for CNRIP1 Gene

  • C2orf32

Previous GeneCards Identifiers for CNRIP1 Gene

  • GC02M068373
  • GC02M068511

Summaries for CNRIP1 Gene

Entrez Gene Summary for CNRIP1 Gene

  • This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for CNRIP1 Gene

CNRIP1 (Cannabinoid Receptor Interacting Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CNRIP1 Gene

  • Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNRIP1 Gene

Genomics for CNRIP1 Gene

Regulatory Elements for CNRIP1 Gene

Enhancers for CNRIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G068120 1.6 FANTOM5 Ensembl ENCODE 11.2 +198.9 198919 1.4 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 SIN3A FEZF1 YY1 ZNF766 WDR92 PNO1 CNRIP1 C1D LOC100287361 LOC105374789
GH02G068794 1.2 Ensembl ENCODE dbSUPER 10.3 -476.0 -475986 3.9 SIX4 ZSCAN26 YBX1 CHD7 FOS HES1 YY2 ZNF521 RNF2 ZNF621 LOC102724389 LINC01888 BMP10 CNRIP1 WDR92 ANXA4 LOC105374790
GH02G068317 1.3 FANTOM5 ENCODE 9.5 +0.8 797 2.9 ZFP64 SIN3A FEZF1 YY1 GLIS2 FOS ZNF263 SP3 MIER2 REST LOC102724389 CNRIP1 ENSG00000273398
GH02G068410 1.4 Ensembl ENCODE dbSUPER 8.3 -92.5 -92500 3.2 TBP PKNOX1 TBL1XR1 BMI1 ZNF766 RCOR1 RELB IKZF2 CREM CEBPB PLEK LOC101927723 CNRIP1 LOC391383
GH02G068436 1 Ensembl dbSUPER 11 -116.7 -116650 0.6 HDAC1 PKNOX1 L3MBTL2 E2F5 BHLHE40 ZEB2 ELF1 ARID1B ZNF766 ZNF589 LOC101927723 PLEK CNRIP1 LOC391383
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNRIP1 on UCSC Golden Path with GeneCards custom track

Promoters for CNRIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000118377 851 2001 ZFP64 SIN3A FEZF1 YY1 GLIS2 FOS SP3 REST SMARCA4 PBX2

Genomic Location for CNRIP1 Gene

Chromosome:
2
Start:
68,284,171 bp from pter
End:
68,320,051 bp from pter
Size:
35,881 bases
Orientation:
Minus strand

Genomic View for CNRIP1 Gene

Genes around CNRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNRIP1 Gene

Proteins for CNRIP1 Gene

  • Protein details for CNRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F85-CNRP1_HUMAN
    Recommended name:
    CB1 cannabinoid receptor-interacting protein 1
    Protein Accession:
    Q96F85
    Secondary Accessions:
    • B2R4D0
    • Q49AN4
    • Q9UFZ0

    Protein attributes for CNRIP1 Gene

    Size:
    164 amino acids
    Molecular mass:
    18648 Da
    Quaternary structure:
    • Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.

    Alternative splice isoforms for CNRIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNRIP1 Gene

Post-translational modifications for CNRIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNRIP1 Gene

No data available for DME Specific Peptides for CNRIP1 Gene

Domains & Families for CNRIP1 Gene

Protein Domains for CNRIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F85

UniProtKB/Swiss-Prot:

CNRP1_HUMAN :
  • Belongs to the CNRIP family.
Family:
  • Belongs to the CNRIP family.
genes like me logo Genes that share domains with CNRIP1: view

No data available for Gene Families for CNRIP1 Gene

Function for CNRIP1 Gene

Molecular function for CNRIP1 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.
genes like me logo Genes that share phenotypes with CNRIP1: view

Animal Model Products

CRISPR Products

miRNA for CNRIP1 Gene

miRTarBase miRNAs that target CNRIP1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNRIP1 Gene

Localization for CNRIP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNRIP1 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with CNRIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CNRIP1 Gene

Pathways & Interactions for CNRIP1 Gene

SuperPathways for CNRIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNRIP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CNRIP1 Gene

Drugs & Compounds for CNRIP1 Gene

(1) Drugs for CNRIP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CNRIP1: view

Transcripts for CNRIP1 Gene

Unigene Clusters for CNRIP1 Gene

Cannabinoid receptor interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNRIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7: - - -
SP8: -

Relevant External Links for CNRIP1 Gene

GeneLoc Exon Structure for
CNRIP1
ECgene alternative splicing isoforms for
CNRIP1

Expression for CNRIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNRIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNRIP1 Gene

This gene is overexpressed in Brain (17.0) and Frontal cortex (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNRIP1 Gene



Protein tissue co-expression partners for CNRIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNRIP1 Gene:

CNRIP1

SOURCE GeneReport for Unigene cluster for CNRIP1 Gene:

Hs.212885

Evidence on tissue expression from TISSUES for CNRIP1 Gene

  • Nervous system(4.8)
  • Eye(4.2)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with CNRIP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNRIP1 Gene

Orthologs for CNRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNRIP1 34 35
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia CNRIP1 34 35
  • 93.5 (n)
oppossum
(Monodelphis domestica)
Mammalia CNRIP1 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNRIP1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNRIP1 34 35
  • 90.64 (n)
mouse
(Mus musculus)
Mammalia Cnrip1 34 16 35
  • 90.04 (n)
rat
(Rattus norvegicus)
Mammalia Cnrip1 34
  • 89.84 (n)
chicken
(Gallus gallus)
Aves CNRIP1 34 35
  • 72.88 (n)
lizard
(Anolis carolinensis)
Reptilia CNRIP1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnrip1 34
  • 69.15 (n)
Str.17250 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.28904 34
zebrafish
(Danio rerio)
Actinopterygii cnrip1b 34 35
  • 64.4 (n)
cnrip1a 35
  • 61 (a)
OneToMany
Dr.6763 34
worm
(Caenorhabditis elegans)
Secernentea F29A7.4 35
  • 19 (a)
OneToOne
Species where no ortholog for CNRIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNRIP1 Gene

ENSEMBL:
Gene Tree for CNRIP1 (if available)
TreeFam:
Gene Tree for CNRIP1 (if available)

Paralogs for CNRIP1 Gene

No data available for Paralogs for CNRIP1 Gene

Variants for CNRIP1 Gene

Sequence variations from dbSNP and Humsavar for CNRIP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000006430 -- 68,304,114(+) CAGGT(A/G)CAGGG intron-variant
rs1000008838 -- 68,295,672(+) ATCTA(C/T)ATAGT intron-variant
rs1000049874 -- 68,286,374(+) ACTTC(A/G)CACCA intron-variant
rs1000251477 -- 68,293,766(+) GGAAC(A/T)GCAAT intron-variant, utr-variant-3-prime
rs1000269640 -- 68,289,591(+) TCCTT(A/C)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNRIP1 Gene

Variant ID Type Subtype PubMed ID
dgv221n21 CNV loss 19592680
nsv524297 CNV loss 19592680

Variation tolerance for CNRIP1 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNRIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNRIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNRIP1 Gene

Disorders for CNRIP1 Gene

Relevant External Links for CNRIP1

Genetic Association Database (GAD)
CNRIP1
Human Genome Epidemiology (HuGE) Navigator
CNRIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNRIP1

No disorders were found for CNRIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNRIP1 Gene

Publications for CNRIP1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? (PMID: 20590557) Smith T.H. … Selley D.E. (Br. J. Pharmacol. 2010) 2 3 64
  3. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. (PMID: 17895407) Niehaus J.L. … Lewis D.L. (Mol. Pharmacol. 2007) 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for CNRIP1 Gene

Sources for CNRIP1 Gene

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