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Aliases for CNRIP1 Gene

Aliases for CNRIP1 Gene

  • Cannabinoid Receptor Interacting Protein 1 2 3
  • C2orf32 3 4
  • CRIP-1 3 4
  • CB1 Cannabinoid Receptor-Interacting Protein 1 3
  • Cannabinoid Receptor CB1-Interacting Protein 1 3
  • Chromosome 2 Open Reading Frame 32 2
  • CRIP1 3

External Ids for CNRIP1 Gene

Previous HGNC Symbols for CNRIP1 Gene

  • C2orf32

Previous GeneCards Identifiers for CNRIP1 Gene

  • GC02M068373
  • GC02M068511

Summaries for CNRIP1 Gene

Entrez Gene Summary for CNRIP1 Gene

  • This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for CNRIP1 Gene

CNRIP1 (Cannabinoid Receptor Interacting Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CNRIP1 Gene

  • Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNRIP1 Gene

Genomics for CNRIP1 Gene

Regulatory Elements for CNRIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNRIP1 Gene

Start:
68,284,171 bp from pter
End:
68,320,051 bp from pter
Size:
35,881 bases
Orientation:
Minus strand

Genomic View for CNRIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNRIP1 Gene

Proteins for CNRIP1 Gene

  • Protein details for CNRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F85-CNRP1_HUMAN
    Recommended name:
    CB1 cannabinoid receptor-interacting protein 1
    Protein Accession:
    Q96F85
    Secondary Accessions:
    • B2R4D0
    • Q49AN4
    • Q9UFZ0

    Protein attributes for CNRIP1 Gene

    Size:
    164 amino acids
    Molecular mass:
    18648 Da
    Quaternary structure:
    • Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.

    Alternative splice isoforms for CNRIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNRIP1 Gene

Proteomics data for CNRIP1 Gene at MOPED

Post-translational modifications for CNRIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNRIP1 Gene

Antibody Products

No data available for DME Specific Peptides for CNRIP1 Gene

Domains for CNRIP1 Gene

Protein Domains for CNRIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F85

UniProtKB/Swiss-Prot:

CNRP1_HUMAN :
  • Q96F85
Family:
  • Belongs to the CNRIP family.
genes like me logo Genes that share domains with CNRIP1: view

No data available for Gene Families for CNRIP1 Gene

Function for CNRIP1 Gene

Molecular function for CNRIP1 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.

Phenotypes for CNRIP1 Gene

GenomeRNAi human phenotypes for CNRIP1:
genes like me logo Genes that share phenotypes with CNRIP1: view

Animal Model Products

CRISPR Products

miRNA for CNRIP1 Gene

miRTarBase miRNAs that target CNRIP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNRIP1 Gene

Localization for CNRIP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNRIP1 Gene COMPARTMENTS Subcellular localization image for CNRIP1 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CNRIP1 Gene

Pathways for CNRIP1 Gene

SuperPathways for CNRIP1 Gene

No Data Available

Interacting Proteins for CNRIP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000263655%0d%0a9606.ENSP00000378890%0d%0a
Selected Interacting proteins: ENSP00000263655 Q96F85-CNRP1_HUMAN for CNRIP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CNRIP1 Gene

None

No data available for Pathways by source for CNRIP1 Gene

Compounds for CNRIP1 Gene

(1) HMDB Compounds for CNRIP1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CNRIP1: view

Transcripts for CNRIP1 Gene

Unigene Clusters for CNRIP1 Gene

Cannabinoid receptor interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNRIP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNRIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7: - - -
SP8: -

Relevant External Links for CNRIP1 Gene

GeneLoc Exon Structure for
CNRIP1
ECgene alternative splicing isoforms for
CNRIP1

Expression for CNRIP1 Gene

mRNA expression in normal human tissues for CNRIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CNRIP1 Gene

This gene is overexpressed in Brain (17.0) and Frontal cortex (13.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNRIP1 Gene

SOURCE GeneReport for Unigene cluster for CNRIP1 Gene Hs.212885

genes like me logo Genes that share expressions with CNRIP1: view

Expression partners for CNRIP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNRIP1 Gene

Orthologs for CNRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNRIP1 35
  • 93.5 (n)
  • 96.95 (a)
CNRIP1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNRIP1 35
  • 90.64 (n)
  • 93.79 (a)
CNRIP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnrip1 35
  • 90.04 (n)
  • 96.34 (a)
Cnrip1 16
Cnrip1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNRIP1 35
  • 99.39 (n)
  • 100 (a)
CNRIP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnrip1 35
  • 89.84 (n)
  • 95.73 (a)
oppossum
(Monodelphis domestica)
Mammalia CNRIP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNRIP1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNRIP1 35
  • 72.88 (n)
  • 72.05 (a)
CNRIP1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNRIP1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnrip1 35
  • 69.15 (n)
  • 67.7 (a)
Str.17250 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.28904 35
zebrafish
(Danio rerio)
Actinopterygii cnrip1b 35
  • 64.4 (n)
  • 60.49 (a)
Dr.6763 35
cnrip1a 36
  • 61 (a)
OneToMany
cnrip1b 36
  • 60 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F29A7.4 36
  • 19 (a)
OneToOne
Species with no ortholog for CNRIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNRIP1 Gene

ENSEMBL:
Gene Tree for CNRIP1 (if available)
TreeFam:
Gene Tree for CNRIP1 (if available)

Paralogs for CNRIP1 Gene

No data available for Paralogs for CNRIP1 Gene

Variants for CNRIP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CNRIP1 Gene

Variant ID Type Subtype PubMed ID
dgv221n21 CNV Loss 19592680
nsv524297 CNV Loss 19592680

Relevant External Links for CNRIP1 Gene

HapMap Linkage Disequilibrium report
CNRIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CNRIP1 Gene

Disorders for CNRIP1 Gene

Relevant External Links for CNRIP1

Genetic Association Database (GAD)
CNRIP1
Human Genome Epidemiology (HuGE) Navigator
CNRIP1

No disorders were found for CNRIP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CNRIP1 Gene

Publications for CNRIP1 Gene

  1. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. (PMID: 17895407) Niehaus J.L. … Lewis D.L. (Mol. Pharmacol. 2007) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? (PMID: 20590557) Smith T.H. … Selley D.E. (Br. J. Pharmacol. 2010) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for CNRIP1 Gene

Sources for CNRIP1 Gene

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