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Aliases for CNRIP1 Gene

Aliases for CNRIP1 Gene

  • Cannabinoid Receptor Interacting Protein 1 2 3 5
  • C2orf32 3 4
  • CRIP-1 3 4
  • Cannabinoid Receptor CB1-Interacting Protein 1 3
  • Chromosome 2 Open Reading Frame 32 2
  • CRIP1 3

External Ids for CNRIP1 Gene

Previous HGNC Symbols for CNRIP1 Gene

  • C2orf32

Previous GeneCards Identifiers for CNRIP1 Gene

  • GC02M068373
  • GC02M068511

Summaries for CNRIP1 Gene

Entrez Gene Summary for CNRIP1 Gene

  • This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for CNRIP1 Gene

CNRIP1 (Cannabinoid Receptor Interacting Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CNRIP1 Gene

  • Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNRIP1 Gene

Genomics for CNRIP1 Gene

Regulatory Elements for CNRIP1 Gene

Promoters for CNRIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNRIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNRIP1 Gene

Chromosome:
2
Start:
68,284,171 bp from pter
End:
68,320,051 bp from pter
Size:
35,881 bases
Orientation:
Minus strand

Genomic View for CNRIP1 Gene

Genes around CNRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNRIP1 Gene

Proteins for CNRIP1 Gene

  • Protein details for CNRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F85-CNRP1_HUMAN
    Recommended name:
    CB1 cannabinoid receptor-interacting protein 1
    Protein Accession:
    Q96F85
    Secondary Accessions:
    • B2R4D0
    • Q49AN4
    • Q9UFZ0

    Protein attributes for CNRIP1 Gene

    Size:
    164 amino acids
    Molecular mass:
    18648 Da
    Quaternary structure:
    • Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.

    Alternative splice isoforms for CNRIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNRIP1 Gene

Proteomics data for CNRIP1 Gene at MOPED

Post-translational modifications for CNRIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNRIP1 Gene

Antibody Products

No data available for DME Specific Peptides for CNRIP1 Gene

Domains & Families for CNRIP1 Gene

Protein Domains for CNRIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F85

UniProtKB/Swiss-Prot:

CNRP1_HUMAN :
  • Belongs to the CNRIP family.
Family:
  • Belongs to the CNRIP family.
genes like me logo Genes that share domains with CNRIP1: view

No data available for Gene Families for CNRIP1 Gene

Function for CNRIP1 Gene

Molecular function for CNRIP1 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.
genes like me logo Genes that share phenotypes with CNRIP1: view

Animal Model Products

CRISPR Products

miRNA for CNRIP1 Gene

miRTarBase miRNAs that target CNRIP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNRIP1 Gene

Localization for CNRIP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNRIP1 Gene COMPARTMENTS Subcellular localization image for CNRIP1 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CNRIP1 Gene

Pathways & Interactions for CNRIP1 Gene

SuperPathways for CNRIP1 Gene

No Data Available

Interacting Proteins for CNRIP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000263655%0d%0a9606.ENSP00000378890%0d%0a
Selected Interacting proteins: Q96F85-CNRP1_HUMAN ENSP00000263655 for CNRIP1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CNRIP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CNRIP1 Gene

Drugs & Compounds for CNRIP1 Gene

(1) Drugs for CNRIP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CNRIP1: view

Transcripts for CNRIP1 Gene

Unigene Clusters for CNRIP1 Gene

Cannabinoid receptor interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNRIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7: - - -
SP8: -

Relevant External Links for CNRIP1 Gene

GeneLoc Exon Structure for
CNRIP1
ECgene alternative splicing isoforms for
CNRIP1

Expression for CNRIP1 Gene

mRNA expression in normal human tissues for CNRIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNRIP1 Gene

This gene is overexpressed in Brain (17.0) and Frontal cortex (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CNRIP1 Gene



SOURCE GeneReport for Unigene cluster for CNRIP1 Gene Hs.212885

genes like me logo Genes that share expression patterns with CNRIP1: view

Protein tissue co-expression partners for CNRIP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNRIP1 Gene

Orthologs for CNRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNRIP1 35
  • 99.39 (n)
  • 100 (a)
CNRIP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNRIP1 36
  • 97 (a)
OneToOne
CNRIP1 35
  • 93.5 (n)
  • 96.95 (a)
dog
(Canis familiaris)
Mammalia CNRIP1 35
  • 90.64 (n)
  • 93.79 (a)
CNRIP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnrip1 36
  • 96 (a)
OneToOne
Cnrip1 16
Cnrip1 35
  • 90.04 (n)
  • 96.34 (a)
oppossum
(Monodelphis domestica)
Mammalia CNRIP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNRIP1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnrip1 35
  • 89.84 (n)
  • 95.73 (a)
chicken
(Gallus gallus)
Aves CNRIP1 36
  • 71 (a)
OneToOne
CNRIP1 35
  • 72.88 (n)
  • 72.05 (a)
lizard
(Anolis carolinensis)
Reptilia CNRIP1 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.28904 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cnrip1 35
  • 69.15 (n)
  • 67.7 (a)
Str.17250 35
zebrafish
(Danio rerio)
Actinopterygii cnrip1a 36
  • 61 (a)
OneToMany
cnrip1b 36
  • 60 (a)
OneToMany
cnrip1b 35
  • 64.4 (n)
  • 60.49 (a)
Dr.6763 35
worm
(Caenorhabditis elegans)
Secernentea F29A7.4 36
  • 19 (a)
OneToOne
Species with no ortholog for CNRIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNRIP1 Gene

ENSEMBL:
Gene Tree for CNRIP1 (if available)
TreeFam:
Gene Tree for CNRIP1 (if available)

Paralogs for CNRIP1 Gene

No data available for Paralogs for CNRIP1 Gene

Variants for CNRIP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CNRIP1 Gene

Variant ID Type Subtype PubMed ID
dgv221n21 CNV Loss 19592680
nsv524297 CNV Loss 19592680

Variation tolerance for CNRIP1 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNRIP1 Gene

HapMap Linkage Disequilibrium report
CNRIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CNRIP1 Gene

Disorders for CNRIP1 Gene

Relevant External Links for CNRIP1

Genetic Association Database (GAD)
CNRIP1
Human Genome Epidemiology (HuGE) Navigator
CNRIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNRIP1

No disorders were found for CNRIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNRIP1 Gene

Publications for CNRIP1 Gene

  1. Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? (PMID: 20590557) Smith T.H. … Selley D.E. (Br. J. Pharmacol. 2010) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. (PMID: 25505242) Fernandez J. … Arhel N.J. (J. Biol. Chem. 2015) 3
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for CNRIP1 Gene

Sources for CNRIP1 Gene

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