CNRIP1 Gene
protein-coding GIFtS: 45
GCID: GC02M068511
|
|
cannabinoid receptor interacting protein 1(Previous name: chromosome 2 open reading frame 32 ) (Previous symbol: C2orf32)
| |
Aliases for CNRIP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Cannabinoid Receptor Interacting Protein 11 2 | | CRIP1b1 | | C2orf321 2 3 | | DKFZP566K19241 | | CRIP11 2 | | Chromosome 2 Open Reading Frame 321 | | CRIP-12 3 | | Cannabinoid Receptor CB1-Interacting Protein 12 | | CRIP1a1 | | CB1 Cannabinoid Receptor-Interacting Protein 12 |
Export aliases for CNRIP1 gene to outside databasesPrevious GC identifers: GC02M068373 GC02M068248 |
Summaries for CNRIP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for CNRIP1: This gene encodes a G-protein coupled receptor which interacts with the C-terminal tail of cannabinoid receptor 1. Thisreceptor plays a role in synaptic plasticity, analgesia, appetite, and neuroprotection. Two transcript variantsencoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: CNRP1_HUMAN, Q96F85Function: Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.Isoform 2 does not have this effect
|
Genomic Views for CNRIP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CNRIP1 gene promoter: TBP Sox5 AML1a GATA-3 FOXD3 GATA-1 FOXL1 SRY MRF-2 Pax-4a Other transcription factors
Search SABiosciences Chromatin IP Primers for CNRIP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNRIP1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p14 Ensembl cytogenetic band: 2p14 HGNC cytogenetic band: 2p13CNRIP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M068511: view genomic region
(about GC identifiers)
Start:
|
68,511,303 bp from pter |
End:
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68,547,183 bp from pter |
Size:
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35,881 bases |
Orientation:
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minus strand |
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Proteins for CNRIP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: CNRP1_HUMAN, Q96F85 (See
protein sequence)Recommended Name: CB1 cannabinoid receptor-interacting protein 1 Size: 164 amino acids; 18648 Da
Subunit: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptorCNR2
Secondary accessions: B2R4D0 Q49AN4 Q9UFZ0Alternative splicing: 2 isoforms: Q96F85-1 Q96F85-2 Explore the universe of human proteins at neXtProt for CNRIP1: NX_Q96F85
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96F85 CNRIP1 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (2 alternative transcripts):
NP_056278.1 NP_001104571.1 ENSEMBL proteins: ENSP00000386883 ENSP00000263655 ENSP00000386544 Human Recombinant Protein Products for CNRIP1:
CNRIP1 Antibody Products: Assay Products for CNRIP1: |
Protein
Domains / Families for CNRIP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96F85 UniProtKB/Swiss-Prot: CNRP1_HUMAN, Q96F85Similarity: Belongs to the CNRIP family |
Function for CNRIP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: CNRP1_HUMAN, Q96F85Function: Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.Isoform 2 does not have this effectPhenotypes: 1 GenomeRNAi human phenotype for CNRIP1: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNRIP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNRIP1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CNRIP1 (NM_015463) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNRIP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNRIP1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNRIP1 |
|
Pathways & Interactions for CNRIP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNRIP1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for CNRIP1 (Q96F853 ENSP000002636554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for CNRIP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for CNRIP1
1 HMDB Compound for CNRIP1 About this table Search CenterWatch for drugs/clinical trials and news about CNRIP1 / CNRP1 
|
Transcripts for CNRIP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for CNRIP1 gene (2 alternative transcripts): NM_015463.2 NM_001111101.1 Unigene Cluster for CNRIP1: Cannabinoid receptor interacting protein 1 Hs.212885 [show with all ESTs]Unigene Representative Sequence: BC0351254 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409559 ENST00000263655(uc002sej.4 uc002sek.4) ENST00000481714 ENST00000409862(uc010fdd.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNRIP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNRIP1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CNRIP1 (NM_015463) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNRIP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNRIP1  |
Additional cDNA sequence: AK092542.1 AK308979.1 AK311784.1 AL110235.1 AY144596.1 BC011535.1 BC035125.1 8 DOTS entries: DT.205366 DT.97793803 DT.95168754 DT.100779819 DT.427903 DT.121020472 DT.95168753 DT.97859131 24/130 AceView cDNA sequences (see all 130): NM_015463 BF447478 BM545726 AJ712806 AI421436 CA431351 CR620224 Z42516 BQ446575 BC011535 BM021974 BQ186463 AW026659 BU947544 BM021482 AI302013 CR596246 CK904309 CR619915 CR613301 BQ027018 AW274508 BX422859 Z38708 GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CNRIP1 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | |
| SP1: | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for CNRIP1
|
Expression for CNRIP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNRIP1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAACTTGCAG
 About this image See CNRIP1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CNRIP1
SOURCE GeneReport for Unigene cluster: Hs.212885 SABiosciences Custom PCR Arrays for CNRIP1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNRIP1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNRIP1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNRIP1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNRIP1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNRIP1 |
Orthologs for CNRIP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CNRIP1 gene from 7/16 species (see all 16) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Cnrip11 , 5 |
cannabinoid receptor interacting protein 11, 5 |
90.04(n)1 96.34(a)1 |
  |
11 (9.50 cM)5 3806861 NM_029861.21 NP_084137.11 170515865 |
chicken (Gallus gallus) |
Aves |
CNRIP11 |
cannabinoid receptor interacting protein 1 |
72.88(n) 72.05(a) |
  |
421266 XM_419337.3 XP_419337.1 |
lizard (Anolis carolinensis) |
Reptilia |
CNRIP16 |
-- |
72(a) |
1 ↔ 1 |
1(126676459-126687300) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.289042 |
Xenopus laevis transcribed sequence with weak similarity more |
79.12(n) |
  |
CD361005.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.67632 |
Transcribed sequence with weak similarity to protein more |
73.2(n) |
  |
57076250 |
honey bee (Apis mellifera) |
Insecta |
-- |
-- |
30(a) |
1 ↔ 1 |
GroupUn.742(21900-32702) |
worm (Caenorhabditis elegans) |
Secernentea |
F29A7.46 |
Protein F29A7.4 |
16(a) |
1 ↔ 1 |
II(2748593-2751578) |
ENSEMBL Gene Tree for CNRIP1 (if available) TreeFam Gene Tree for CNRIP1 (if available)  |
Paralogs for CNRIP1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for CNRIP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for CNRIP1 (68511303 - 68547183 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CNRIP1 1 CNV: 50549  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNRIP1 |
|
Disorders
/ Diseases for CNRIP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CNRIP1 for disorders About MalaCards
CNRIP1 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: CNRIP1 (1 document) Export disorders for CNRIP1 gene to outside databases
|
Publications for CNRIP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CNRIP1 gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with CNRIP1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. (PubMed id 17895407)1, 2 Niehaus J.L....Lewis D.L. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions. (PubMed id 16696853)1 Swick L. and Kapatos G. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for CNRIP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CNRIP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CNRIP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CNRIP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for CNRIP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CNRIP1 gene: Search GeneIP for patents involving CNRIP1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for CNRIP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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| |
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| | | Search Tocris compounds for CNRIP1 |
| |  |  |  |  | | | | | Recombinant Protein for CNRIP1 |
|
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 |
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 | | CNRIP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNRIP1 |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNRIP1 |
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