Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CNR2 Gene

protein-coding   GIFtS: 67
GCID: GC01M024197

Cannabinoid Receptor 2 (Macrophage)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cannabinoid Receptor 2 (Macrophage)1 2     Testis-Dominant CNR2 Isoform CB22
CB22 3 5     CB2A3
CX52 3 5     CB2B3
CB-22 3     hCB23
Cannabinoid Receptor 22     

External Ids:    HGNC: 21601   Entrez Gene: 12692   Ensembl: ENSG000001888227   OMIM: 6050515   UniProtKB: P349723   

Export aliases for CNR2 gene to outside databases

Previous GC identifers: GC01M023725 GC01M023271 GC01M9A0006 GC01M9A3945 GC01M023945 GC01M024069 GC01M022452


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CNR2 Gene:
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins
encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine
nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity
in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be
involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by
users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CNR2 Gene:
CNR2 (cannabinoid receptor 2 (macrophage)) is a protein-coding gene. Diseases associated with CNR2 include pertussis, and chronic pain. GO annotations related to this gene include cannabinoid receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972
Function: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating
inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone
homeostasis

summary for CNR2 Gene:
The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor
group of G-protein-coupled receptors that also includes CB1 and GPR55. They are located primarily in immune
cells both within & outside the central nervous system. The function of these receptors includes modulation
of cytokine release and immune cell migration. In the brain CB2 receptors are expressed by microglia, blood
vessels & some neurons.

Gene Wiki entry for CNR2 (Cannabinoid receptor type 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNR2 gene promoter:
         GR   STAT1   AP-1   ATF-2   STAT5A   CREB   deltaCREB   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNR2 promoter sequence
   Search Chromatin IP Primers for CNR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p

CNR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNR2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M024197:  view genomic region     (about GC identifiers)

Start:
24,197,016 bp from pter      End:
24,285,549 bp from pter
Size:
88,534 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972 (See protein sequence)
Recommended Name: Cannabinoid receptor 2  
Size: 360 amino acids; 39681 Da
1 PDB 3D structure from and Proteopedia for CNR2:
2KI9 (3D)    
Secondary accessions: C6ES44 Q4VBK8 Q5JRH7 Q6B0G7 Q6NSY0

Explore the universe of human proteins at neXtProt for CNR2: NX_P34972

Explore proteomics data for CNR2 at MOPED

Post-translational modifications: 

  • Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the
    receptor1
  • Glycosylation2 at Asn11
  • Modification sites at PhosphoSitePlus

  • See CNR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001832.1  
    ENSEMBL proteins: 
     ENSP00000363596   ENSP00000442830  
    Reactome Protein details: P34972

    CNR2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CNR2 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CNR2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CNR2
    GenScript Custom Purified and Recombinant Proteins Services for CNR2
    Novus Biologicals CNR2 Proteins
    Novus Biologicals CNR2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNR2

    CNR2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CNR2
    R&D Systems Antibodies for CNR2 (Cannabinoid R2/CB2/CNR2)
    OriGene Antibodies for CNR2
    OriGene Custom Antibody Services for CNR2
    Novus Biologicals CNR2 Antibodies
    Abcam antibodies for CNR2
    Cloud-Clone Corp. Antibodies for CNR2
    ThermoFisher Antibody for CNR2
    LSBio Antibodies in human, mouse, rat for CNR2

    CNR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CNR2
    Browse R&D Systems for biochemical assays
    GenScript CNR2-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNR2
    Cloud-Clone Corp. CLIAs for CNR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CNR: GPCR / Class A : Cannabinoid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CB2 receptor
    Cannabinoid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001551 Canbinoid_rcpt_2
     IPR002230 Cnbnoid_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P34972

    ProtoNet protein and cluster: P34972

    2 Blocks protein domains:
    IPB001551 Cannabinoid receptor type 2 signature
    IPB002230 Cannabinoid receptor signature


    UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CNR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNR2_HUMAN, P34972
    Function: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating
    inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone
    homeostasis

         Genatlas biochemistry entry for CNR2:
    cannabinoid receptor 2,peripheral,expressed in spleen,inhibiting adenylate cyclase

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004949cannabinoid receptor activity IEA--
         
    CNR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CNR2:
     Decreased substrate adherent c 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cnr2):
     hematopoietic system  immune system  integument  reproductive system 

    CNR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CNR2: Cnr2tm1Zim Cnr2tm1Dgen

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNR2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CNR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CNR2
    SwitchGear 3'UTR luciferase reporter plasmidCNR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CNR2
    Predesigned siRNA for gene silencing in human, mouse, rat CNR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CNR2

    Clone
    Products:
         
    OriGene clones in human, mouse for CNR2 (see all 6)
    OriGene ORF clones in mouse, rat for CNR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNR2 (NM_001841)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNR2

    Cell Line
    Products:
         
    GenScript CNR2-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for CNR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CNR2_HUMAN, P34972: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite (By similarity).
    Perikaryon (By similarity). Note=Localizes to apical dendrite of pyramidal neurons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    extracellular1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8679694
    GO:0016021integral component of membrane ----
    GO:0030425dendrite IEA--
    GO:0031234extrinsic component of cytoplasmic side of plasma membrane IEA--

    CNR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CNR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Eicosanoid ligand-binding receptors
    Small Ligand GPCRs0.31
    4Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CNR2
        Reelin Pathway (Cajal-Retzius cells)

    2 BioSystems Pathways for CNR2
        GPCRs, Class A Rhodopsin-like
    Small Ligand GPCRs

    2 Reactome Pathways for CNR2
        G alpha (i) signalling events
    Class A/1 (Rhodopsin-like receptors)


    1 Kegg Pathway  (Kegg details for CNR2):
        Neuroactive ligand-receptor interaction


    CNR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CNR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CNR2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CNR2 (P349723 ENSP000003635964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNA15P306793, ENSP000002629584I2D: score=2 STRING: ENSP00000262958
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS7556170
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8679694

    CNR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CNR2
      Browse compounds at ApexBio 

    Compounds for CNR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HU 308Potent and selective CB2 agonist[256934-39-1]
    AM 630CB2 selective antagonist/inverse agonist[164178-33-0]
    GP 1aHighly selective CB2 agonist[511532-96-0]
    JWH 133 (in Tocrisolve 100) Potent, selective CB2 agonist (in water-soluble emulsion) [259869-55-1]
    JWH 133 Potent, selective CB2 agonist [259869-55-1]

    2 DrugBank Compounds for CNR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Nabilone-- 51022-71-0targetpartial agonist17139494 15221424 11786493 11698062 17450170
    Dronabinol-- 1972-08-3targetagonist17139494 19226257

    Selected IUPHAR Ligands for CNR2 (CB2 receptor) (see all 16)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]HU-243
    AgonistFull agonist10.27498464
    HU-210
    AgonistFull agonist9.3 - 9.88819477 9379442 7565624
    [3H]CP55940
    AgonistFull agonist8.1 - 9.78819477 8647116 7565624 8679694 7689702 8636122
    WIN55212-2
    AgonistFull agonist8.4 - 9.68819477 7565624 8679694
    CP55940
    AgonistFull agonist8.6 - 9.28819477 7565624 10188977
    SR144528
    AntagonistAntagonist8.2 - 9.29454810 10188977
    [3H]WIN55212-2
    AgonistFull agonist8.4 - 8.77689702 7651369
    JWH-133
    AgonistFull agonist8.510658595 11060760
    L-759,633
    AgonistFull agonist7.7 - 8.210188977
    AM1241
    AgonistAgonist8.116894349

    Selected Novoseek inferred chemical compound relationships for CNR2 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-arachidonoylglycerol 93.6 52 12711605 (2), 17110113 (2), 18092149 (2), 15548432 (1) (see all 26)
    anandamide 93 53 18599552 (2), 11920199 (2), 12411414 (2), 19171674 (2) (see all 32)
    sr144528 90.6 12 16547349 (3), 12514329 (2), 16406050 (1), 11920199 (1) (see all 9)
    am630 86.4 6 17189959 (1), 18431074 (1), 20233580 (1), 19858202 (1) (see all 6)
    cp55940 86.3 9 19237169 (2), 17017986 (1), 16436496 (1), 17362921 (1)
    delta9-tetrahydrocannabinol 85.3 20 17041005 (2), 16436496 (2), 18431074 (1), 7565624 (1) (see all 13)
    rimonabant 82.9 10 18692962 (1), 18806815 (1), 15700028 (1), 17961655 (1) (see all 5)
    am251 82.6 5 16406050 (1), 18431074 (1), 19477951 (1), 20233580 (1)
    cannabinol 80.6 6 16436496 (2), 7565624 (1), 9379442 (1)
    cannabidiol 80.5 8 12952947 (2), 16754784 (1), 17876302 (1), 18806815 (1) (see all 6)



    CNR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CNR2 gene: 
    NM_001841.2  

    Unigene Cluster for CNR2:

    Cannabinoid receptor 2 (macrophage)
    Hs.73037  [show with all ESTs]
    Unigene Representative Sequence: EU517121
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374472(uc001bif.3) ENST00000536471
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CNR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CNR2
    SwitchGear 3'UTR luciferase reporter plasmidCNR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CNR2
    Predesigned siRNA for gene silencing in human, mouse, rat CNR2
    Clone
    Products:
         
    OriGene clones in human, mouse for CNR2 (see all 6)
    OriGene ORF clones in mouse, rat for CNR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNR2 (NM_001841)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNR2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CNR2
    OriGene qSTAR qPCR primer pairs in human, mouse for CNR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNR2
      QuantiTect SYBR Green Assays in human, mouse, rat CNR2
      QuantiFast Probe-based Assays in human, mouse, rat CNR2

    Additional mRNA sequence: 

    AJ430063.1 AM156854.1 AM156855.1 AM156856.1 BC069722.1 BC074767.2 BC095545.1 EU517121.1 
    FJ357036.1 X74328.1 

    6 DOTS entries:

    DT.454590  DT.206342  DT.100695206  DT.40247805  DT.70102607  DT.75126197 

    Selected AceView cDNA sequences (see all 32):

    BC074767 AJ430063 BC069722 BX327912 BV203596 BI836468 AL551812 CN832619 
    CN838083 BX327913 BV203594 BV203595 BV203600 X74328 AW503816 NM_001841 
    AL527378 BV203599 AI492725 AA311385 AA745732 BV198040 CN832766 CN837918 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CNR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAACCCTG
    CNR2 Expression
    About this image


    CNR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
    CNR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73037

    UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972
    Tissue specificity: Preferentially expressed in cells of the immune system with higher expression in B-cells and
    NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly
    expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus.
    PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells
    and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter
    usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in
    brain, while isoform CB2B is predominant in spleen and leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including CNR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CNR2
    OriGene qSTAR qPCR primer pairs in human, mouse for CNR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNR2
    QuantiTect SYBR Green Assays in human, mouse, rat CNR2
    QuantiFast Probe-based Assays in human, mouse, rat CNR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CNR2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnr21 , 5 cannabinoid receptor 2 (macrophage)1, 5 82.32(n)1
    82.71(a)1
      4 (68.01 cM)5
    128021  NM_009924.31  NP_034054.31 
     1358953945 
    chicken
    (Gallus gallus)
    Aves CNR21 cannabinoid receptor 2 (macrophage) 56.11(n)
    50.44(a)
      428232  XM_004947898.1  XP_004947955.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNR26
    cannabinoid receptor 2 (macrophage)
    54(a)
    1 ↔ 1
    GL343498.1(67367-68305)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cnr21 cannabinoid receptor 2 (macrophage) 54.98(n)
    50.57(a)
      100498271  XM_002938742.2  XP_002938788.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cnr21 cannabinoid receptor 2 51.04(n)
    45.94(a)
      795246  NM_212964.3  NP_998129.3 


    ENSEMBL Gene Tree for CNR2 (if available)
    TreeFam Gene Tree for CNR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CNR2 gene
    CNR12  GPR122  LPAR22  S1PR12  S1PR32  S1PR22  LPAR12  MC1R2  
    MC3R2  MC5R2  MC2R2  GPR32  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    1 SIMAP similar gene for CNR2 using alignment to 1 protein entry:     CNR2_HUMAN:
    CNR1

    CNR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CNR2 (see all 1214)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421346581,2
    Cuntested124202065(+) GCCATA/C/TCTTGG 2 N D mis10--------
    rs30033351,2
    C,F--24200052(+) GAGCTG/ATATTC 1 -- ds500113Minor allele frequency- A:0.30NA WA CSA EA 376
    rs66657331,2
    C,F--24200158(+) AGGGGC/TGTGGA 1 -- ds5001 ese312Minor allele frequency- T:0.30NA WA CSA EA 374
    rs1452372781,2
    --24200164(+) GTGGAA/GGAGGC 1 -- ds50010--------
    rs286680811,2
    F--24200177(+) GGGAGC/G/TTGAAT 1 -- ds5001 ese30--------
    rs1156956671,2
    F--24200203(+) GAACAG/ATTTGG 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs11303211,2
    C,F--24200524(-) CCGAGA/GACTAT 1 -- ut31 ese321Minor allele frequency- N:0.00EA NA MN WA CSA 1136
    rs1866455131,2
    --24200527(+) GTCCTC/TGGTCC 1 -- ut310--------
    rs11303201,2
    C,F--24200606(-) TTCTCC/TCTGCC 1 -- ut31 ese3 trp317Minor allele frequency- T:0.36NA MN WA CSA EA 701
    rs11061,2
    C,F,A--24200772(-) ACAGGC/GTCAGT 1 -- ut31 ese315Minor allele frequency- G:0.32NA MN WA CSA EA 699

    HapMap Linkage Disequilibrium report for CNR2 (24197016 - 24285549 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CNR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745386CNV Deletion23290073
    esv2672735CNV Deletion23128226
    esv991485CNV Insertion20482838
    nsv512727CNV Insertion21212237
    esv1663042CNV Insertion17803354
    esv29329CNV Loss19812545
    dgv29n67CNV Loss20364138

    Human Gene Mutation Database (HGMD): CNR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CNR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605051    OMIM disorders: --

    Selected diseases for CNR2 (see all 64):    
    About MalaCards
    pertussis    chronic pain    bulimia nervosa    eating disorder
    aortic valve stenosis    liver disease    osteoporosis    mantle cell lymphoma
    acute pancreatitis    fatty liver disease    primary biliary cirrhosis    mood disorder
    anorexia nervosa    autism spectrum disorder    tonsillitis    multiple sclerosis
    purpura    celiac disease    diffuse large b-cell lymphoma    b-cell lymphomas


    CNR2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CNR2 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver fibrosis 52.6 3 18029545 (1), 17412522 (1), 16407142 (1)
    multiple sclerosis 45.4 3 16570099 (1), 16512913 (1), 18208367 (1)
    catalepsy 44.3 1 15814101 (1)
    inflammation 37.7 9 17484889 (1), 15814101 (1), 16343349 (1), 17767170 (1) (see all 6)
    obesity 37.2 1 19474722 (1)
    chronic liver disease 34.5 1 17298297 (1)
    glioma 30.3 10 18175076 (5), 16893424 (1), 15453094 (1), 17239827 (1)
    osteoporosis 17.6 4 19565271 (1), 19143566 (1), 18426503 (1), 16407142 (1)
    cirrhosis 14.7 2 18029545 (1)
    alzheimers disease 4.72 1 18615177 (1)

    Genetic Association Database (GAD): CNR2
    Human Genome Epidemiology (HuGE) Navigator: CNR2 (14 documents)

    Export disorders for CNR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CNR2 gene, integrated from 10 sources (see all 346):
    (articles sorted by number of sources associating them with CNR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. (PubMed id 18286196)1, 2, 4, 9 Onaivi E.S.... Uhl G.R. (PLoS ONE 2008)
    2. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. (PubMed id 7556170)1, 2, 9 Galiegue S.... Casellas P. (Eur. J. Biochem. 1995)
    3. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. (PubMed id 19496827)1, 2, 9 Liu Q.R.... Uhl G.R. (Genes Brain Behav. 2009)
    4. Common polymorphisms in the cannabinoid CB2 receptor gene (CNR2) are not associated with myocardial infarction and cardiovascular risk factors. (PubMed id 18636169)1, 4, 9 Reinhard W....Hengstenberg C. (Int. J. Mol. Med. 2008)
    5. The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. (PubMed id 19565271)1, 4, 9 Karsak M....Livshits G. (Hum. Genet. 2009)
    6. Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosis. (PubMed id 19730968)1, 4, 9 Floreani A....Bergasa N.V. (J. Gastroenterol. 2010)
    7. Brain cannabinoid CB2 receptor in schizophrenia. (PubMed id 19931854)1, 4, 9 Ishiguro H....Arinami T. (Biol. Psychiatry 2010)
    8. Cannabinoid receptor type 2 gene is associated with human osteoporosis. (PubMed id 16204352)1, 4, 9 Karsak M....Zimmer A. (Hum. Mol. Genet. 2005)
    9. 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. (PubMed id 12711605)1, 2, 9 Kishimoto S....Sugiura T. (J. Biol. Chem. 2003)
    10. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1269 HGNC: 2160 AceView: CNR2 Ensembl:ENSG00000188822 euGenes: HUgn1269
    ECgene: CNR2 Kegg: 1269 H-InvDB: CNR2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CNR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CNR2 gene:
    Search GeneIP for patents involving CNR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of CNR2
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant CNR2 Protein
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for CNR2 (Cannabinoid R2/CB2/CNR2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for CNR2 (Cannabinoid R2/CB2/CNR2)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CNR2   OriGene RNAi products in human, mouse, rat for CNR2  
     OriGene qPCR primer pairs and template standards for CNR2   OriGene Protein Over-expression Lysate for CNR2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CNR2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CNR2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CNR2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CNR2   OriGene Custom Protein Services for CNR2  

     
     
     Block miRNA regulation of human, mouse, rat CNR2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CNR2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNR2 Predesigned siRNA for gene silencing in human, mouse, rat CNR2
     QuantiFast Probe-based Assays in human, mouse, rat CNR2 QuantiTect SYBR Green Assays in human, mouse, rat CNR2
     PCR Arrays including human, mouse, rat CNR2 Search Chromatin IP Primers for CNR2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNR2  GeneGlobe Interaction Network for CNR2
     Regulatory tfbs in CNR2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CNR2 GenScript cDNA clones with any tag delivered in your preferred vector for CNR2
     GenScript CNR2-overexpressing Cell Line for Assay CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for CNR2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for CNR2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CNR2 antibodies
     CNR2 proteins
     CNR2 lysates
     Antibodies for CNR2
     See all of Abcam's Antibodies, Kits and Proteins for CNR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CNR2
     Antibodies for CNR2
     ELISAs for CNR2
     CLIAs for CNR2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CNR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNR2
     SwitchGear 3'UTR luciferase reporter plasmids for CNR2
     SwitchGear Promoter luciferase reporter plasmids for CNR2
     ThermoFisher Antibody for CNR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNR2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNR2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNR2
     LSBio Antibodies in human, mouse, rat for CNR2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CNR2 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4