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GIFtS

CNR2 Gene

protein-coding   GIFtS: 66
GCID: GC01M024197

cannabinoid receptor 2 (macrophage)
 Explore 64 diseases affiliated with
CNR2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CNR2    

Aliases
for CNR2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cannabinoid Receptor 2 (Macrophage)1 2     Cannabinoid Receptor 22
CB21 2 3 5     Testis-Dominant CNR2 Isoform CB22
CX52 3 5     HCB21
CB-22 3     

External Ids:    HGNC: 21601   Entrez Gene: 12692   Ensembl: ENSG000001888227   OMIM: 6050515   UniProtKB: P349723   

Export aliases for CNR2 gene to outside databases

Previous GC identifers: GC01M023725 GC01M023271 GC01M9A0006 GC01M9A3945 GC01M023945 GC01M024069 GC01M022452


Summaries
for CNR2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CNR2:
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins
encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine
nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a
dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved
in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of
marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972
Function: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of
adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis

summary for CNR2:
The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor
group of G-protein-coupled receptors that also includes CB1 and GPR55. They are located primarily in immune
cells both within & outside the central nervous system. The function of these receptors includes modulation
of cytokine release and immune cell migration. In the brain CB2 receptors are expressed by microglia, blood
vessels & some neurons.

Gene Wiki entry for CNR2 (Cannabinoid receptor type 2)


Genomic Views
for CNR2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNR2 gene promoter:
         GR   STAT1   AP-1   ATF-2   STAT5A   CREB   deltaCREB   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p

CNR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNR2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M024197:  view genomic region     (about GC identifiers)

Start:
 24,197,016 bp from pter      End:
 24,285,549 bp from pter
Size:
 88,534 bases      Orientation:
 minus strand

Proteins
for CNR2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972 (See protein sequence)
Recommended Name: Cannabinoid receptor 2  
Size: 360 amino acids; 39681 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite (By similarity). Perikaryon
(By similarity). Note=Localizes to apical dendrite of pyramidal neurons (By similarity)
1 PDB 3D structure from and Proteopedia for CNR2:
2KI9 (3D)    
Secondary accessions: Q4VBK8 Q5JRH7 Q6B0G7 Q6NSY0

Explore the universe of human proteins at neXtProt for CNR2: NX_P34972

Post-translational modifications:

  • Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P34972

    • CNR2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001832.1  
    ENSEMBL proteins: 
     ENSP00000363596   ENSP00000442830  
    Reactome Protein details: P34972
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CNR2 Protein
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    Novus Biologicals CNR2 Proteins
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    Uscn Proteins for CNR2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8679694
    GO:0019717synaptosome ----
    GO:0030425dendrite IEA--
    GO:0031234extrinsic to internal side of plasma membrane IEA--


    CNR2 for ontologies           About GeneDecksing



    CNR2 Antibody Products: 
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    Uscn ELISAs and CLIAs for CNR2

    Protein Domains /
    Families
    for CNR2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CNR2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001551 Canbinoid_rcpt_2
     IPR002230 Cnbnoid_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P34972

    ProtoNet protein and cluster: P34972

    2 Blocks protein families:
    IPB001551 Cannabinoid receptor type 2 signature
    IPB002230 Cannabinoid receptor signature


    UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for CNR2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972
    Function: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of
    adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis

         Genatlas biochemistry entry for CNR2:
    cannabinoid receptor 2,peripheral,expressed in spleen,inhibiting adenylate cyclase

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNR2
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    SwitchGear 3'UTR luciferase reporter plasmid: CNR2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNR2 (see all 7)
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNR2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CNR2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNR2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004949cannabinoid receptor activity IEA--


    CNR2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CNR2:
     Decreased substrate adherent c 

    Animal Models:
         Mouse knock-outs for CNR2: Cnr2tm1Zim Cnr2tm1Dgen
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cnr2):
     immune system  integument  reproductive system 

    CNR2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CNR2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		GPCRs, Class A Rhodopsin-like0.41
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    		G alpha (i) signalling events0.44
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Reelin Pathway (Cajal-Retzius cells)
    		Reelin Pathway (Cajal-Retzius cells)1.00
    4Prostanoid ligand receptors
    		Small Ligand GPCRs0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CNR2
        Reelin Pathway (Cajal-Retzius cells)

    2 BioSystems Pathways for CNR2 
        GPCRs, Class A Rhodopsin-like
    Small Ligand GPCRs

    5/6        Reactome Pathways for CNR2 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events
    GPCR ligand binding


    1         Kegg Pathway  (Kegg details for CNR2):
        Neuroactive ligand-receptor interaction


    CNR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNR2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CNR2 (P349723 ENSP000003635964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNA15P306793, ENSP000002629584I2D: score=2 STRING: ENSP00000262958
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS7556170
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8679694


    CNR2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CNR2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CNR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CNR2

    Compounds for CNR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HU 308Potent and selective CB2 agonist[256934-39-1]
    JWH 133 Potent, selective CB2 agonist [259869-55-1]
    JTE 907Selective CB2 receptor antagonist/inverse agonist[282089-49-0]
    AM 630CB2 selective antagonist/inverse agonist[164178-33-0]
    GP 1aHighly selective CB2 agonist--

    2 DrugBank Compounds for CNR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Nabilone-- 51022-71-0targetpartial agonist17139494 15221424 11786493 11698062 17450170
    Dronabinol-- 1972-08-3targetagonist17139494 19226257

    10/35 Novoseek chemical compound relationships for CNR2 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-arachidonoylglycerol 93.6 52 12711605 (2), 17110113 (2), 18092149 (2), 15548432 (1) (see all 26)
    anandamide 93 53 18599552 (2), 11920199 (2), 12411414 (2), 19171674 (2) (see all 32)
    sr144528 90.6 12 16547349 (3), 12514329 (2), 16406050 (1), 11920199 (1) (see all 9)
    am630 86.4 6 17189959 (1), 18431074 (1), 20233580 (1), 19858202 (1) (see all 6)
    cp55940 86.3 9 19237169 (2), 17017986 (1), 16436496 (1), 17362921 (1)
    delta9-tetrahydrocannabinol 85.3 20 17041005 (2), 16436496 (2), 18431074 (1), 7565624 (1) (see all 13)
    rimonabant 82.9 10 18692962 (1), 18806815 (1), 15700028 (1), 17961655 (1) (see all 5)
    am251 82.6 5 16406050 (1), 18431074 (1), 19477951 (1), 20233580 (1)
    cannabinol 80.6 6 16436496 (2), 7565624 (1), 9379442 (1)
    cannabidiol 80.5 8 12952947 (2), 16754784 (1), 17876302 (1), 18806815 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about CNR2 

    Transcripts
    for CNR2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CNR2 gene: 
    NM_001841.2  

    Unigene Cluster for CNR2:

    Cannabinoid receptor 2 (macrophage)
    Hs.73037  [show with all ESTs]
    Unigene Representative Sequence: EU517121
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374472(uc001bif.3) ENST00000536471

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNR2
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AJ430063.1 AM156854.1 AM156855.1 AM156856.1 BC069722.1 BC074767.2 BC095545.1 EU517121.1 
    FJ357036.1 X74328.1 

    6 DOTS entries:

    DT.454590  DT.206342  DT.100695206  DT.40247805  DT.70102607  DT.75126197 

    24/32 AceView cDNA sequences (see all 32):

    BC074767 AJ430063 BI836468 BC069722 AL527378 CN838083 BV203594 BX327912 
    X74328 AW503816 AL551812 BV203600 BV203596 BV203595 BX327913 CN832619 
    BV203599 NM_001841 AA311385 AI492725 BV198040 AA745732 CN837918 CN832766 

    GeneLoc Exon Structure


    Expression
    for CNR2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCAACCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CNR2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CNR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNR2

    SOURCE GeneReport for Unigene cluster: Hs.73037

    UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972
    Tissue specificity: Preferentially expressed in cells of the immune system with higher expression in B-cells and NK
    cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly
    expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172
    could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root
    ganglion sensory neurons (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including CNR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNR2

    Orthologs
    for CNR2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CNR2 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CNR21 cannabinoid receptor 2 (macrophage) 56.57(n)
    51.21(a)    		   428232  XM_425791.1  XP_425791.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CNR26
    		 --
    		 54(a)
    		 1 ↔ 1
    		 GL343498.1(67367-68305)
    zebrafish
    (Danio rerio)    		 Actinopterygii cnr21 cannabinoid receptor 2 50.79(n)
    45.74(a)    		   795246  NM_212964.3  NP_998129.3 


    ENSEMBL Gene Tree for CNR2 (if available)
    TreeFam Gene Tree for CNR2 (if available) 

    Paralogs
    for CNR2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNR2 gene
    CNR12  GPR122  ENSG000002675342  LPAR22  S1PR12  S1PR32  LPAR12  MC1R2  
    MC3R2  MC5R2  GPR32  MC2R2  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    1 SIMAP similar gene for CNR2 using alignment to 2 protein entries:     CNR2_HUMAN (see all proteins):
    CNR1

    CNR2 for paralogs           About GeneDecksing



    Genomic Variants
    for CNR2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1087 NCBI SNPs in CNR2 are shown (see all 1087)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs30033351,2
    		C,F,--24200052(+) GAGCTG/ATATTC 1 -- ds500113Minor allele frequency- A:0.30NA WA CSA EA 376
    rs66657331,2
    		C,F,--24200158(+) AGGGGC/TGTGGA 1 -- ds5001 ese312Minor allele frequency- T:0.30NA WA CSA EA 374
    rs1452372781,2
    		--24200164(+) GTGGAA/GGAGGC 1 -- ds50010--------
    rs286680811,2
    		--24200177(+) GGGAGC/G/TTGAAT 1 -- ds5001 ese30--------
    rs1156956671,2
    		F,--24200203(+) GAACAG/ATTTGG 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs11303211,2
    		C,F,--24200524(-) CCGAGA/GACTAT 1 -- ut31 ese321Minor allele frequency- N:0.00EA NA MN WA CSA 1136
    rs1866455131,2
    		--24200527(+) GTCCTC/TGGTCC 1 -- ut310--------
    rs11303201,2
    		C,F,--24200606(-) TTCTCC/TCTGCC 1 -- ut31 ese3 trp317Minor allele frequency- T:0.36NA MN WA CSA EA 701
    rs11061,2
    		C,F,A,--24200772(-) ACAGGC/GTCAGT 1 -- ut31 ese315Minor allele frequency- G:0.32NA MN WA CSA EA 699
    rs11051,2
    		C,F,A,H,--24200800(-) CAGGTG/AGGCGA 1 -- ut3126Minor allele frequency- A:0.32NA NS EA WA CSA 2490

    HapMap Linkage Disequilibrium report for CNR2 (24197016 - 24285549 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CNR2
         3 CNVs: 23358 84130 63279
    Human Gene Mutation Database (HGMD): CNR2

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    Disorders / Diseases
    for CNR2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CNR2 for disorders           About GeneDecksing

    OMIM gene information: 605051    OMIM disorders: --

    20/64 diseases for CNR2 (see all 64):    About MalaCards
    pertussis    diffuse large b-cell lymphoma    b-cell lymphomas    non-hodgkin lymphoma
    type 2 diabetes mellitus    autism spectrum disorder    bulimia nervosa    primary biliary cirrhosis
    amyotrophic lateral sclerosis    lateral sclerosis    mantle cell lymphoma    anorexia nervosa
    hodgkin's lymphoma    eating disorder    diabetes mellitus    chronic pain
    multiple sclerosis    osteoporosis    neuronitis    myocardial infarction

    10/18 Novoseek disease relationships for CNR2 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver fibrosis 52.6 3 18029545 (1), 17412522 (1), 16407142 (1)
    multiple sclerosis 45.4 3 16570099 (1), 16512913 (1), 18208367 (1)
    catalepsy 44.3 1 15814101 (1)
    inflammation 37.7 9 17484889 (1), 15814101 (1), 16343349 (1), 17767170 (1) (see all 6)
    obesity 37.2 1 19474722 (1)
    chronic liver disease 34.5 1 17298297 (1)
    glioma 30.3 10 18175076 (5), 16893424 (1), 15453094 (1), 17239827 (1)
    osteoporosis 17.6 4 19565271 (1), 19143566 (1), 18426503 (1), 16407142 (1)
    cirrhosis 14.7 2 18029545 (1)
    alzheimers disease 4.72 1 18615177 (1)

    Genetic Association Database (GAD): CNR2
    Human Genome Epidemiology (HuGE) Navigator: CNR2 (14 documents)

    Export disorders for CNR2 gene to outside databases

    Publications
    for CNR2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNR2 gene, integrated from 9 sources (see all 334):
    (articles sorted by number of sources associating them with CNR2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. (PubMed id 7556170)1, 2, 9 Galiegue S.... Casellas P. (1995)
    2. Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. (PubMed id 18286196)1, 2, 9 Onaivi E.S....Uhl G.R. (2008)
    3. Cannabinoid receptor type 2 gene is associated with human osteoporosis. (PubMed id 16204352)1, 4, 9 Karsak M....Zimmer A. (2005)
    4. 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. (PubMed id 12711605)1, 2, 9 Kishimoto S....Sugiura T. (2003)
    5. Structural biology of human cannabinoid receptor-2 he lix 6 in membrane-mimetic environments. (PubMed id 19397896)1, 2 Tiburu E.K....Makriyannis A. (2009)
    6. Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. (PubMed id 15266552)1, 2 Nunez E....Romero J. (2004)
    7. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. (PubMed id 14657172)1, 2 Benito C....Romero J. (2003)
    8. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. (PubMed id 12511587)1, 2 Casanova M.L.... Guzman M. (2003)
    9. Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor. (PubMed id 12663043)1, 2 Feng W. and Song Z.H. (2003)
    10. Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function. (PubMed id 12417328)1, 2 Song Z.H. and Feng W. (2002)

    External Searches for CNR2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CNR2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1269 HGNC: 2160 AceView: CNR2 Ensembl:ENSG00000188822 euGenes: HUgn1269
    ECgene: CNR2 Kegg: 1269 H-InvDB: CNR2

    Other Databases showing CNR2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CNR2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNR2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CNR2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CNR2 gene:
    Search GeneIP for patents involving CNR2

    GeneCards and IP:
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