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Aliases for CNR2 Gene

Aliases for CNR2 Gene

  • Cannabinoid Receptor 2 (Macrophage) 2 3
  • CB2 3 4 6
  • CX5 3 4 6
  • CB-2 3 4
  • Testis-Dominant CNR2 Isoform CB2 3
  • Cannabinoid Receptor 2 3
  • CB2A 4
  • CB2B 4
  • HCB2 4

External Ids for CNR2 Gene

Previous GeneCards Identifiers for CNR2 Gene

  • GC01M023725
  • GC01M023271
  • GC01M9A0006
  • GC01M9A3945
  • GC01M023945
  • GC01M024069
  • GC01M024197
  • GC01M022452

Summaries for CNR2 Gene

Entrez Gene Summary for CNR2 Gene

  • The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNR2 Gene

CNR2 (Cannabinoid Receptor 2 (Macrophage)) is a Protein Coding gene. Diseases associated with CNR2 include pertussis and chronic pain. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include cannabinoid receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for CNR2 Gene

  • Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Tocris Summary for CNR2 Gene

  • The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB1 and GPR55. They are located primarily in immune cells both within & outside the central nervous system. The function of these receptors includes modulation of cytokine release and immune cell migration. In the brain CB2 receptors are expressed by microglia, blood vessels & some neurons.

Gene Wiki entry for CNR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNR2 Gene

Genomics for CNR2 Gene

Regulatory Elements for CNR2 Gene

Genomic Location for CNR2 Gene

23,870,515 bp from pter
23,959,054 bp from pter
88,540 bases
Minus strand

Genomic View for CNR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNR2 Gene

Proteins for CNR2 Gene

  • Protein details for CNR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cannabinoid receptor 2
    Protein Accession:
    Secondary Accessions:
    • C6ES44
    • Q4VBK8
    • Q5JRH7
    • Q6B0G7
    • Q6NSY0

    Protein attributes for CNR2 Gene

    360 amino acids
    Molecular mass:
    39681 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CNR2 Gene

neXtProt entry for CNR2 Gene

Proteomics data for CNR2 Gene at MOPED

Post-translational modifications for CNR2 Gene

  • Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
  • Glycosylation at Asn11
  • Modification sites at PhosphoSitePlus

Other Protein References for CNR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CNR2 (Cannabinoid R2/CB2/CNR2)

No data available for DME Specific Peptides for CNR2 Gene

Domains for CNR2 Gene

Gene Families for CNR2 Gene

  • CNR :GPCR / Class A : Cannabinoid receptors

Suggested Antigen Peptide Sequences for CNR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P34972
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CNR2: view

Function for CNR2 Gene

Molecular function for CNR2 Gene

GENATLAS Biochemistry:
cannabinoid receptor 2,peripheral,expressed in spleen,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Gene Ontology (GO) - Molecular Function for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004949 cannabinoid receptor activity IEA --
genes like me logo Genes that share ontologies with CNR2: view
genes like me logo Genes that share phenotypes with CNR2: view

Animal Models for CNR2 Gene

MGI Knock Outs for CNR2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CNR2 Gene

Localization for CNR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNR2 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CNR2 Gene COMPARTMENTS Subcellular localization image for CNR2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8679694
GO:0016021 integral component of membrane --
GO:0030425 dendrite IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CNR2: view

Pathways for CNR2 Gene

genes like me logo Genes that share pathways with CNR2: view

Pathways by source for CNR2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 7556170
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8679694
genes like me logo Genes that share ontologies with CNR2: view

Compounds for CNR2 Gene

Compound Products

(5) Tocris Compounds for CNR2 Gene

Compound Action Cas Number
AM 630 CB2 selective antagonist/inverse agonist [164178-33-0]
GP 1a Highly selective CB2 agonist [511532-96-0]
HU 308 Potent and selective CB2 agonist [256934-39-1]
JWH 133 Potent, selective CB2 agonist [259869-55-1]
JWH 133 (in Tocrisolve� 100) Potent, selective CB2 agonist (in water-soluble emulsion) [259869-55-1]

(7) ApexBio Compounds for CNR2 Gene

Compound Action Cas Number
AM1241 "Cannabinoid CB2 receptor agonist,potent and selective" [444912-48-5]
AM251 Potent CB1 antagonist [183232-66-8]
BML-190 CB2 receptor ligand [2854-32-2]
CP-945598 HCl "CB1 antagonist,selective and high affinity" [686347-12-6]
GW842166X [666260-75-9]
Org 27569 Cannabinoid CB1 receptor allosteric modulator [868273-06-7]
Rimonabant CB1 receptor antagonist [168273-06-1]

(2) Drugbank Compounds for CNR2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1972-08-3 target agonist
51022-71-0 target partial agonist

(16) IUPHAR Ligand for CNR2 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]HU-243 Agonist Full agonist 10.2
[3H]CP55940 Agonist Full agonist 9.7
CP55940 Agonist Full agonist 9.2
SR144528 Antagonist Antagonist 9.2
[3H]WIN55212-2 Agonist Full agonist 8.7
JWH-133 Agonist Full agonist 8.5
L-759,633 Agonist Full agonist 8.2
AM1241 Agonist Agonist 8.1
L-759,656 Agonist Full agonist 7.9
AM630 Antagonist Antagonist 7.5
HU-210 Antagonist Antagonist 7
2-arachidonoylglycerol Agonist Partial agonist 6.8
WIN55212-2 Antagonist Antagonist 6.7
HU-308 Antagonist Antagonist 6
Delta9-tetrahydrocannabinol Channel blocker None
anandamide Channel blocker None

(35) Novoseek inferred chemical compound relationships for CNR2 Gene

Compound -log(P) Hits PubMed IDs
2-arachidonoylglycerol 93.6 29
anandamide 93 37
sr144528 90.6 12
am630 86.4 6
cp55940 86.3 5
genes like me logo Genes that share compounds with CNR2: view

Transcripts for CNR2 Gene

Unigene Clusters for CNR2 Gene

Cannabinoid receptor 2 (macrophage):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNR2 Gene

No ASD Table

Relevant External Links for CNR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNR2 Gene

mRNA expression in normal human tissues for CNR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNR2 Gene

This gene is overexpressed in Spleen (19.6), Small Intestine - Terminal Ileum (7.1), and Whole Blood (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNR2 Gene

SOURCE GeneReport for Unigene cluster for CNR2 Gene Hs.73037

mRNA Expression by UniProt/SwissProt for CNR2 Gene

Tissue specificity: Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5 UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.
genes like me logo Genes that share expressions with CNR2: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for CNR2 Gene

Orthologs for CNR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNR2 35
  • 84.22 (n)
  • 82.73 (a)
CNR2 36
  • 82 (a)
(Canis familiaris)
Mammalia CNR2 35
  • 85 (n)
  • 82.22 (a)
CNR2 36
  • 82 (a)
(Mus musculus)
Mammalia Cnr2 35
  • 82.32 (n)
  • 82.71 (a)
Cnr2 16
Cnr2 36
  • 83 (a)
(Pan troglodytes)
Mammalia CNR2 35
  • 99.26 (n)
  • 99.72 (a)
CNR2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cnr2 35
  • 81.85 (n)
  • 81.11 (a)
(Monodelphis domestica)
Mammalia CNR2 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia CNR2 36
  • 57 (a)
(Gallus gallus)
Aves CNR2 35
  • 56.11 (n)
  • 50.44 (a)
CNR2 36
  • 50 (a)
(Anolis carolinensis)
Reptilia CNR2 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnr2 35
  • 54.98 (n)
  • 50.57 (a)
(Danio rerio)
Actinopterygii cnr2 35
  • 51.04 (n)
  • 45.94 (a)
cnr2 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
-- 36
  • 23 (a)
Species with no ortholog for CNR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNR2 Gene

Gene Tree for CNR2 (if available)
Gene Tree for CNR2 (if available)

Paralogs for CNR2 Gene

Selected SIMAP similar genes for CNR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNR2: view

Variants for CNR2 Gene

Sequence variations from dbSNP and Humsavar for CNR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1105 -- 23,874,310(-) CAGGT(A/G)GGCGA utr-variant-3-prime
rs1106 -- 23,874,282(-) ACAGG(C/G)TCAGT utr-variant-3-prime
rs1130316 -- 23,874,266(-) TCAGG(A/T)CAGGC utr-variant-3-prime
rs1130320 -- 23,874,116(-) TTCTC(C/T)CTGCC utr-variant-3-prime
rs1130321 -- 23,874,034(-) CCGAG(A/G)ACTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CNR2 Gene

Variant ID Type Subtype PubMed ID
esv29329 CNV Loss 19812545
dgv29n67 CNV Loss 20364138
esv991485 CNV Insertion 20482838
nsv512727 CNV Insertion 21212237
esv1663042 CNV Insertion 17803354
esv2672735 CNV Deletion 23128226
esv2745386 CNV Deletion 23290073

Relevant External Links for CNR2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNR2 Gene

Disorders for CNR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CNR2 Gene in MalaCards »

(2) Diseases for CNR2 Gene including...

(18) Novoseek inferred disease relationships for CNR2 Gene

Disease -log(P) Hits PubMed IDs
liver fibrosis 52.6 3
multiple sclerosis 45.4 3
catalepsy 44.3 1
inflammation 37.7 6
obesity 37.2 1

Relevant External Links for CNR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CNR2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CNR2 Gene

Publications for CNR2 Gene

  1. Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. (PMID: 18286196) Onaivi E.S. … Uhl G.R. (PLoS ONE 2008) 3 4 23 48
  2. Common polymorphisms in the cannabinoid CB2 receptor gene (CNR2) are not associated with myocardial infarction and cardiovascular risk factors. (PMID: 18636169) Reinhard W. … Hengstenberg C. (Int. J. Mol. Med. 2008) 3 23 48
  3. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. (PMID: 7556170) Galiegue S. … Casellas P. (Eur. J. Biochem. 1995) 3 4 23
  4. 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. (PMID: 12711605) Kishimoto S. … Sugiura T. (J. Biol. Chem. 2003) 3 4 23
  5. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. (PMID: 19496827) Liu Q.R. … Uhl G.R. (Genes Brain Behav. 2009) 3 4 23

Products for CNR2 Gene

Sources for CNR2 Gene

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