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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNR2 Gene

protein-coding   GIFtS: 67
GCID: GC01M024197

Cannabinoid Receptor 2 (Macrophage)

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cannabinoid Receptor 2 (Macrophage)1 2     Cannabinoid Receptor 22
CB22 3 5     Testis-Dominant CNR2 Isoform CB22
CX52 3 5     hCB23
CB-22 3     

External Ids:    HGNC: 21601   Entrez Gene: 12692   Ensembl: ENSG000001888227   OMIM: 6050515   UniProtKB: P349723   

Export aliases for CNR2 gene to outside databases

Previous GC identifers: GC01M023725 GC01M023271 GC01M9A0006 GC01M9A3945 GC01M023945 GC01M024069 GC01M022452


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNR2 Gene:
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins
encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine
nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity
in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be
involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by
users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CNR2 Gene: 
CNR2 (cannabinoid receptor 2 (macrophage)) is a protein-coding gene. Diseases associated with CNR2 include pertussis, and chronic pain, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include cannabinoid receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972
Function: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating
inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone
homeostasis

summary for CNR2 Gene:
The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor
group of G-protein-coupled receptors that also includes CB1 and GPR55. They are located primarily in immune
cells both within & outside the central nervous system. The function of these receptors includes modulation
of cytokine release and immune cell migration. In the brain CB2 receptors are expressed by microglia, blood
vessels & some neurons.

Gene Wiki entry for CNR2 (Cannabinoid receptor type 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNR2 gene promoter:
         GR   STAT1   AP-1   ATF-2   STAT5A   CREB   deltaCREB   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p

CNR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNR2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M024197:  view genomic region     (about GC identifiers)

Start:
24,197,016 bp from pter      End:
24,285,549 bp from pter
Size:
88,534 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972 (See protein sequence)
Recommended Name: Cannabinoid receptor 2  
Size: 360 amino acids; 39681 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite (By similarity).
Perikaryon (By similarity). Note=Localizes to apical dendrite of pyramidal neurons (By similarity)
1 PDB 3D structure from and Proteopedia for CNR2:
2KI9 (3D)    
Secondary accessions: Q4VBK8 Q5JRH7 Q6B0G7 Q6NSY0

Explore the universe of human proteins at neXtProt for CNR2: NX_P34972

Explore proteomics data for CNR2 at MOPED 

Post-translational modifications:

  • UniProtKB: Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the
    receptor
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P34972

  • CNR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNR2 Protein Expression
    REFSEQ proteins: NP_001832.1  
    ENSEMBL proteins: 
     ENSP00000363596   ENSP00000442830  
    Reactome Protein details: P34972
    Human Recombinant Protein Products for CNR2: 
    EMD Millipore Purified and/or Recombinant CNR2 Protein
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    Novus Biologicals CNR2 Proteins
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNR2 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8679694
    GO:0016021integral to membrane ----
    GO:0030425dendrite IEA--
    GO:0031234extrinsic to internal side of plasma membrane IEA--

    CNR2 for ontologies           About GeneDecksing



    CNR2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for CNR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CNR: GPCR / Class A : Cannabinoid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CB2 receptor 
    Cannabinoid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001551 Canbinoid_rcpt_2
     IPR002230 Cnbnoid_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P34972

    ProtoNet protein and cluster: P34972

    2 Blocks protein domains:
    IPB001551 Cannabinoid receptor type 2 signature
    IPB002230 Cannabinoid receptor signature


    UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CNR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNR2_HUMAN, P34972
    Function: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating
    inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone
    homeostasis

         Genatlas biochemistry entry for CNR2:
    cannabinoid receptor 2,peripheral,expressed in spleen,inhibiting adenylate cyclase

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004949cannabinoid receptor activity IEA--
         
    CNR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CNR2:
     Decreased substrate adherent c 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cnr2):
     immune system  integument  reproductive system 

    CNR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CNR2: Cnr2tm1Zim Cnr2tm1Dgen

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNR2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNR2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNR2 

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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of CNR2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNR2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CNR2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Prostanoid ligand receptors
    Small Ligand GPCRs0.40
    4Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CNR2
        Reelin Pathway (Cajal-Retzius cells)

    2 BioSystems Pathways for CNR2
        GPCRs, Class A Rhodopsin-like
    Small Ligand GPCRs

    5/6        Reactome Pathways for CNR2 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events
    GPCR ligand binding


    1         Kegg Pathway  (Kegg details for CNR2):
        Neuroactive ligand-receptor interaction


    CNR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNR2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CNR2 (P349723 ENSP000003635964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNA15P306793, ENSP000002629584I2D: score=2 STRING: ENSP00000262958
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS7556170
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8679694

    CNR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CNR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CNR2

    Compounds for CNR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HU 308Potent and selective CB2 agonist[256934-39-1]
    AM 630CB2 selective antagonist/inverse agonist[164178-33-0]
    GP 1aHighly selective CB2 agonist[511532-96-0]
    JWH 133 (in Tocrisolve 100) Potent, selective CB2 agonist (in water-soluble emulsion) [259869-55-1]
    JWH 133 Potent, selective CB2 agonist [259869-55-1]

    2 DrugBank Compounds for CNR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Nabilone-- 51022-71-0targetpartial agonist17139494 15221424 11786493 11698062 17450170
    Dronabinol-- 1972-08-3targetagonist17139494 19226257

    10/16 IUPHAR Ligands for CNR2 (CB2 receptor) (see all 16)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]HU-243
    AgonistFull agonist10.27498464
    HU-210
    AgonistFull agonist9.3 - 9.88819477 9379442 7565624
    [3H]CP55940
    AgonistFull agonist8.1 - 9.78819477 8647116 7565624 8679694 7689702 8636122
    WIN55212-2
    AgonistFull agonist8.4 - 9.68819477 7565624 8679694
    CP55940
    AgonistFull agonist8.6 - 9.28819477 7565624 10188977
    SR144528
    AntagonistAntagonist8.2 - 9.29454810 10188977
    [3H]WIN55212-2
    AgonistFull agonist8.4 - 8.77689702 7651369
    JWH-133
    AgonistFull agonist8.510658595 11060760
    L-759,633
    AgonistFull agonist7.7 - 8.210188977
    AM1241
    AgonistAgonist8.116894349

    10/35 Novoseek inferred chemical compound relationships for CNR2 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-arachidonoylglycerol 93.6 52 12711605 (2), 17110113 (2), 18092149 (2), 15548432 (1) (see all 26)
    anandamide 93 53 18599552 (2), 11920199 (2), 12411414 (2), 19171674 (2) (see all 32)
    sr144528 90.6 12 16547349 (3), 12514329 (2), 16406050 (1), 11920199 (1) (see all 9)
    am630 86.4 6 17189959 (1), 18431074 (1), 20233580 (1), 19858202 (1) (see all 6)
    cp55940 86.3 9 19237169 (2), 17017986 (1), 16436496 (1), 17362921 (1)
    delta9-tetrahydrocannabinol 85.3 20 17041005 (2), 16436496 (2), 18431074 (1), 7565624 (1) (see all 13)
    rimonabant 82.9 10 18692962 (1), 18806815 (1), 15700028 (1), 17961655 (1) (see all 5)
    am251 82.6 5 16406050 (1), 18431074 (1), 19477951 (1), 20233580 (1)
    cannabinol 80.6 6 16436496 (2), 7565624 (1), 9379442 (1)
    cannabidiol 80.5 8 12952947 (2), 16754784 (1), 17876302 (1), 18806815 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about CNR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNR2 gene: 
    NM_001841.2  

    Unigene Cluster for CNR2:

    Cannabinoid receptor 2 (macrophage)
    Hs.73037  [show with all ESTs]
    Unigene Representative Sequence: EU517121
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374472(uc001bif.3) ENST00000536471

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    Additional mRNA sequence: 

    AJ430063.1 AM156854.1 AM156855.1 AM156856.1 BC069722.1 BC074767.2 BC095545.1 EU517121.1 
    FJ357036.1 X74328.1 

    6 DOTS entries:

    DT.454590  DT.206342  DT.100695206  DT.40247805  DT.70102607  DT.75126197 

    24/32 AceView cDNA sequences (see all 32):

    BC074767 AJ430063 BI836468 AW503816 NM_001841 CN832619 AL527378 AL551812 
    BC069722 CN838083 X74328 BV203594 BV203596 BV203595 BV203599 BX327913 
    BX327912 BV203600 BV198040 AI492725 AA311385 AA745732 AA765188 CN837918 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNR2 expression in normal human tissues (normalized intensities)      CNR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAACCCTG
    CNR2 Expression
    About this image


    CNR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             LYMPH NODE   
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Endothelium (Cardiovascular System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Blood (Extraembryonic Tissues)
             umbilical cord reticulocytes   

    See CNR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNR2

    SOURCE GeneReport for Unigene cluster: Hs.73037

    UniProtKB/Swiss-Prot: CNR2_HUMAN, P34972
    Tissue specificity: Preferentially expressed in cells of the immune system with higher expression in B-cells and
    NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly
    expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus.
    PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells
    and dorsal root ganglion sensory neurons (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including CNR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CNR2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnr21 , 5 cannabinoid receptor 2 (macrophage)1, 5 82.32(n)1
    82.71(a)1
      4 (68.01 cM)5
    128021  NM_009924.31  NP_034054.31 
     1358953945 
    chicken
    (Gallus gallus)
    Aves CNR21 cannabinoid receptor 2 (macrophage) 56.57(n)
    51.21(a)
      428232  XM_425791.1  XP_425791.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNR26
    Uncharacterized protein
    54(a)
    1 ↔ 1
    GL343498.1(67367-68305)
    zebrafish
    (Danio rerio)
    Actinopterygii cnr21 cannabinoid receptor 2 50.79(n)
    45.74(a)
      795246  NM_212964.3  NP_998129.3 


    ENSEMBL Gene Tree for CNR2 (if available)
    TreeFam Gene Tree for CNR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNR2 gene
    CNR12  GPR122  LPAR22  S1PR12  S1PR32  S1PR22  LPAR12  MC1R2  
    MC3R2  MC5R2  MC2R2  GPR32  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    1 SIMAP similar gene for CNR2 using alignment to 2 protein entries:     CNR2_HUMAN (see all proteins):
    CNR1

    CNR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1214 SNPs in CNR2 are shown (see all 1214)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421346581,2
    Cuntested124202065(+) GCCATA/C/TCTTGG 2 N D mis10--------
    rs30033351,2
    C,F--24200052(+) GAGCTG/ATATTC 1 -- ds500113Minor allele frequency- A:0.30NA WA CSA EA 376
    rs66657331,2
    C,F--24200158(+) AGGGGC/TGTGGA 1 -- ds5001 ese312Minor allele frequency- T:0.30NA WA CSA EA 374
    rs1452372781,2
    --24200164(+) GTGGAA/GGAGGC 1 -- ds50010--------
    rs286680811,2
    F--24200177(+) GGGAGC/G/TTGAAT 1 -- ds5001 ese30--------
    rs1156956671,2
    F--24200203(+) GAACAG/ATTTGG 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs11303211,2
    C,F--24200524(-) CCGAGA/GACTAT 1 -- ut31 ese321Minor allele frequency- N:0.00EA NA MN WA CSA 1136
    rs1866455131,2
    --24200527(+) GTCCTC/TGGTCC 1 -- ut310--------
    rs11303201,2
    C,F--24200606(-) TTCTCC/TCTGCC 1 -- ut31 ese3 trp317Minor allele frequency- T:0.36NA MN WA CSA EA 701
    rs11061,2
    C,F,A--24200772(-) ACAGGC/GTCAGT 1 -- ut31 ese315Minor allele frequency- G:0.32NA MN WA CSA EA 699

    HapMap Linkage Disequilibrium report for CNR2 (24197016 - 24285549 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CNR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745386CNV Deletion23290073
    esv2672735CNV Deletion23128226
    esv991485CNV Insertion20482838
    nsv512727CNV Insertion21212237
    esv1663042CNV Insertion17803354
    esv29329CNV Loss19812545
    dgv29n67CNV Loss20364138


    Human Gene Mutation Database (HGMD): CNR2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CNR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CNR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605051    OMIM disorders: --

    20/61 diseases for CNR2 (see all 61):    About MalaCards
    pertussis    chronic pain    bulimia nervosa    eating disorder
    skin cancer    mantle cell lymphoma    acute pancreatitis    primary biliary cirrhosis
    autism spectrum disorder    tonsillitis    anorexia nervosa    multiple sclerosis
    diffuse large b-cell lymphoma    liver disease    mood disorder    fatty liver disease
    b-cell lymphomas    purpura    encephalitis    gingivitis


    CNR2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/18 Novoseek inferred disease relationships for CNR2 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver fibrosis 52.6 3 18029545 (1), 17412522 (1), 16407142 (1)
    multiple sclerosis 45.4 3 16570099 (1), 16512913 (1), 18208367 (1)
    catalepsy 44.3 1 15814101 (1)
    inflammation 37.7 9 17484889 (1), 15814101 (1), 16343349 (1), 17767170 (1) (see all 6)
    obesity 37.2 1 19474722 (1)
    chronic liver disease 34.5 1 17298297 (1)
    glioma 30.3 10 18175076 (5), 16893424 (1), 15453094 (1), 17239827 (1)
    osteoporosis 17.6 4 19565271 (1), 19143566 (1), 18426503 (1), 16407142 (1)
    cirrhosis 14.7 2 18029545 (1)
    alzheimers disease 4.72 1 18615177 (1)

    Genetic Association Database (GAD): CNR2
    Human Genome Epidemiology (HuGE) Navigator: CNR2 (14 documents)

    Export disorders for CNR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNR2 gene, integrated from 9 sources (see all 342):
    (articles sorted by number of sources associating them with CNR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. (PubMed id 18286196)1, 2, 4, 9 Onaivi E.S....Uhl G.R. (2008)
    2. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. (PubMed id 7556170)1, 2, 9 Galiegue S.... Casellas P. (1995)
    3. Common polymorphisms in the cannabinoid CB2 receptor gene (CNR2) are not associated with myocardial infarction and cardiovascular risk factors. (PubMed id 18636169)1, 4, 9 Reinhard W....Hengstenberg C. (2008)
    4. The cannabinoid receptor type 2 (CNR2) gene is associ ated with hand bone strength phenotypes in an ethnically homogeneous family sam ple. (PubMed id 19565271)1, 4, 9 Karsak M....Livshits G. (2009)
    5. Hepatic expression of endocannabinoid receptors and t heir novel polymorphisms in primary biliary cirrhosis. (PubMed id 19730968)1, 4, 9 Floreani A....Bergasa N.V. (2009)
    6. Brain cannabinoid CB2 receptor in schizophrenia. (PubMed id 19931854)1, 4, 9 Ishiguro H....Arinami T. (2010)
    7. Cannabinoid receptor type 2 gene is associated with human osteoporosis. (PubMed id 16204352)1, 4, 9 Karsak M....Zimmer A. (2005)
    8. 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. (PubMed id 12711605)1, 2, 9 Kishimoto S....Sugiura T. (2003)
    9. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1269 HGNC: 2160 AceView: CNR2 Ensembl:ENSG00000188822 euGenes: HUgn1269
    ECgene: CNR2 Kegg: 1269 H-InvDB: CNR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNR2 gene:
    Search GeneIP for patents involving CNR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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