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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CNR1 Gene

protein-coding GIFtS: 68
GCID: GC06M088850

cannabinoid receptor 1 (brain)

(Previous symbol: CNR)

Explore 121 diseases affiliated with
CNR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cannabinoid Receptor 1 (Brain)¹ ²		CB1A¹ ²
CANN6¹ ² ³		CB1K5¹ ²
CB-R¹ ² ³		CB1R²
CB1¹ ² ³		Cannabinoid Receptor 1²
CNR¹ ² ³		Central Cannabinoid Receptor²

External Ids:	HGNC: 2159¹	Entrez Gene: 1268²	Ensembl: ENSG00000118432⁷	OMIM: 114610⁵	UniProtKB: P21554³

Export aliases for CNR1 gene to outside databases

Previous GC identifers: GC06M088795 GC06M088845 GC06M088906 GC06M086064

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNR1:

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and

synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the

guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a

dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved

in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of

marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.

(provided by RefSeq, May 2009)

UniProtKB/Swiss-Prot: CNR1_HUMAN, P21554

Function: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for

anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding

summary for CNR1:

The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor

group of G-protein-coupled receptors that also includes CB2 and GPR55. They are found mainly in the

terminals of central and peripheral neurons where they usually mediate inhibition of neurotransmitter

release. They can also be present on some non-neuronal cells, including immune cells.

Gene Wiki entry for CNR1 (Cannabinoid receptor type 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CNR1 gene promoter:
GR AP-1 ATF-2 GR-alpha c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNR1 promoter sequence

Search SABiosciences Chromatin IP Primers for CNR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14-q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q14-q15

CNR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNR1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M088850: view genomic region (about GC identifiers)

Start:	88,849,583 bp from pter	End:	88,876,078 bp from pter
Size:	26,496 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNR1_HUMAN, P21554 (See protein sequence)

Recommended Name: Cannabinoid receptor 1

Size: 472 amino acids; 52858 Da

Subunit: Interacts (via C-terminus) with CNRIP1

Subcellular location: Cell membrane; Multi-pass membrane protein

4 PDB 3D structures from and Proteopedia for CNR1:

1LVQ (3D)

1LVR (3D)

2B0Y (3D)

2KOE (3D)

Secondary accessions: B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0

Alternative splicing: 3 isoforms: P21554-1 P21554-2 P21554-3

Explore the universe of human proteins at neXtProt for CNR1: NX_P21554

Post-translational modifications:

Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P21554

CNR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001153698.1 NP_001153730.1 NP_001153731.1 NP_057167.2 NP_149421.2

ENSEMBL proteins:

ENSP00000358513 ENSP00000358511 ENSP00000446819 ENSP00000355418 ENSP00000420188

ENSP00000412192 ENSP00000446702 ENSP00000442689 ENSP00000441046 ENSP00000449549

Reactome Protein details: P21554
Human Recombinant Protein Products:

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	Uscn Proteins for CNR1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005792	microsome	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	1718258
GO:0016021	integral to membrane	--	--

CNR1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CNR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CNR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000810 Cnoid_rcpt_1

IPR002230 Cnbnoid_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P21554

ProtoNet protein and cluster: P21554

2 Blocks protein families:

IPB000810 Cannabinoid receptor type 1 signature

IPB002230 Cannabinoid receptor signature

UniProtKB/Swiss-Prot: CNR1_HUMAN, P21554

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CNR1_HUMAN, P21554

Function: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for

anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding

Genatlas biochemistry entry for CNR1:

cannabinoid receptor 1,expressed in brain,testis,located in the eye-ciliary epithelium,corneal epithelium,endothelium

of anterior eye retina,inhibiting adenylate cyclaselocated in and/or one cone pedicles and rod spherules,also

inhibiting voltage-gated L-type calcium channel current in retinal bipolar cells,putatively involved for

endogenouscannaloid system in retinal physiology,G protein coupled receptor superfamily

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNR1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004949	cannabinoid receptor activity	IDA	18761332
GO:0005515	protein binding	--	--
GO:0008144	drug binding	IEA	--

CNR1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CNR1:

Synthetic lethal with imatinib

Animal Models:
Mouse knock-outs for CNR1: Cnr1^tm1Lex Cnr1^tm1Ojm Cnr1^tm1.1Ltz Cnr1^tm1Zim Cnr1^tm1Map
14 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Cnr1):

adipose tissue	behavior/neurological	cellular	digestive/alimentary	growth/size
homeostasis/metabolism	integument	mortality/aging	nervous system	no phenotypic analysis
other	reproductive system	skeleton	taste/olfaction

CNR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Reelin Pathway (Cajal-Retzius cells)

Reelin Pathway (Cajal-Retzius cells)

1.00

N-cadherin signaling events

N-cadherin signaling events

1.00

G-Beta Gamma Signaling

CRHR Pathway

0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CNR1

	Reelin Pathway (Cajal-Retzius cells)
	CRHR Pathway

3 BioSystems Pathways for CNR1

	GPCRs, Class A Rhodopsin-like
	N-cadherin signaling events
	Small Ligand GPCRs

5/6 Reactome Pathways for CNR1 (see all 6)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events
	GPCR ligand binding

1 Kegg Pathway (Kegg details for CNR1):

Neuroactive ligand-receptor interaction

CNR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CNR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for CNR1 (P21554³ ENSP00000358511⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADORA2A	P29274³, ENSP00000336630⁴	I2D: score=4 STRING: ENSP00000336630
GNA15	P30679³, ENSP00000262958⁴	I2D: score=2 STRING: ENSP00000262958
MET	P08581³, ENSP00000317272⁴	I2D: score=1 STRING: ENSP00000317272
GNAI1	P63096³, ENSP00000343027⁴	I2D: score=2 STRING: ENSP00000343027
GNAI2	P04899³, ENSP00000312999⁴	I2D: score=3 STRING: ENSP00000312999

About this table

Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	IEA	--
GO:0006950	response to stress	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	--	--
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	1718258
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IDA	18761332

CNR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CNR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for CNR1

Compounds for CNR1 available from Tocris Bioscience About this table

Compound	Action	CAS #
CP 945598 hydrochloride	CB1 receptor antagonist	[686347-12-6]
PF 514273	Potent and selective CB1 antagonist	[851728-60-4]
AM 251	Potent CB1 antagonist. Also GPR55 agonist	[183232-66-8]
MJ 15	Potent and selective CB1 antagonist	[944154-76-1]
O-2050	CB1 silent antagonist	--

1 HMDB Compound for CNR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Anandamide	Anandamide (20.4, n-6) (see all 13)	94421-68-8	--

3 DrugBank Compounds for CNR1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Nabilone	--	51022-71-0	target	partial agonist	10575283 8864542 17139494 11752352 11698062 8981483
Dronabinol	--	1972-08-3	target	agonist	12686391 11204352 17139284 11752352 17016423
Rimonabant	SR 141716 (see all 4)	158681-13-1	target	antagonist	11752352 8636122

10/97 Novoseek chemical compound relationships for CNR1 gene (see all 97) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
anandamide	97.1	430	9658204 (4), 8395053 (4), 9070252 (3), 11425567 (3) (see all 99)
2-arachidonoylglycerol	95.8	231	17110113 (4), 12711605 (3), 15115777 (3), 16462096 (3) (see all 99)
rimonabant	94.4	152	15836887 (3), 12690115 (3), 18480689 (2), 16697306 (2) (see all 92)
delta9-tetrahydrocannabinol	93	145	15749859 (3), 16436496 (3), 14966196 (2), 15385362 (2) (see all 76)
cp55940	92.1	27	18582849 (2), 12005350 (2), 17558435 (1), 17922024 (1) (see all 19)
sr144528	90.8	28	16406050 (1), 10716447 (1), 11160626 (1), 14966196 (1) (see all 22)
am251	88.2	22	16406050 (1), 17270342 (1), 17922024 (1), 18431074 (1) (see all 18)
cannabidiol	85.6	30	17245363 (5), 15700028 (2), 12443781 (2), 12952947 (2) (see all 15)
cp55	85	1	12005350 (1)
palmitoylethanolamide	84.5	10	11485574 (2), 10692582 (1), 18501510 (1), 12570018 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about CNR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CNR1 gene (6 alternative transcripts):

NM_001160226.1 NM_001160258.1 NM_001160259.1 NM_016083.4 NM_033181.3 NM_001160260.1

Unigene Cluster for CNR1:

Cannabinoid receptor 1 (brain)

Hs.75110 [show with all ESTs]

Unigene Representative Sequence: NM_001160258

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369501(uc003pmq.4) ENST00000369499 ENST00000549890(uc021zco.1)

ENST00000362094 ENST00000468898(uc010kca.3) ENST00000428600 ENST00000551417

ENST00000535130(uc010kbz.3 uc011dzr.2 uc011dzs.2 uc011dzt.2)

ENST00000537554 ENST00000549716

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Additional cDNA sequence:

AF107262.1 AK313908.1 AY766182.1 AY995204.1 BC037581.1 BC074811.2 BC074812.2 BC095513.1

BC100968.1 BC100969.1 BC100970.1 BC100971.1 BX538191.1 DQ067455.1 X81120.1 X81121.1

5 DOTS entries:

DT.453009 DT.100742992 DT.95094150 DT.121346884 DT.121346886

24/74 AceView cDNA sequences (see all 74):

T33929 Z39809 NM_016083 R20626 AA808253 AW296383 AA433954 AI433599

AI149484 AI168685 X81121 AA232660 BG056131 Z43750 AA806670 BM682178

CK823364 AA729268 BC074811 NM_033181 AA729349 BC074812 AA806678 AI784573

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CNR1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b
SP1:			-
SP2:					-

ECgene alternative splicing isoforms for CNR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CNR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAACATAA

About this image

CNR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

Ventral/hypothalamic-like neurons (Generation of midbra...)

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CNR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNR1

SOURCE GeneReport for Unigene cluster: Hs.75110

UniProtKB/Swiss-Prot: CNR1_HUMAN, P21554

Tissue specificity: Widely expressed

SABiosciences Expression via Pathway-Focused PCR Arrays including CNR1:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Obesity in human mouse rat

Huntington's Disease in human mouse rat

Synaptic Plasticity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CNR1 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CNR1¹	cannabinoid receptor 1 (brain)	81.95(n) 93.63(a)		428633 NM_001038652.1 NP_001033741.1
lizard (Anolis carolinensis)	Reptilia	CNR1⁶	--	84(a)	1 ↔ 1	1(175942673-175944094)
African clawed frog (Xenopus laevis)	Amphibia	cnr1-A²	cannabinoid receptor 1/CB1	74.64(n)		AY098532.1
zebrafish (Danio rerio)	Actinopterygii	cnr1¹	cannabinoid receptor 1	70.61(n) 74.78(a)		404209 NM_212820.1 NP_997985.1

ENSEMBL Gene Tree for CNR1 (if available)
TreeFam Gene Tree for CNR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CNR1 gene

GPR12² ENSG00000267534² LPAR2² S1PR1² CNR2² S1PR3² LPAR1² MC1R²

MC3R² MC5R² GPR3² MC2R² MC4R² S1PR4² GPR6² LPAR3²

S1PR5²

1 SIMAP similar gene for CNR1 using alignment to 4 protein entries: CNR1_HUMAN (see all proteins):

CNR2

CNR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182716059^1,2		--	88849138(+)	`TCATTA/GTAAAA`	5	--	ds500¹		0	--	--	--	--
rs144772600^1,2		--	88849275(+)	`GTACTA/GTGTCT`	5	--	ds500¹		0	--	--	--	--
rs186153980^1,2		--	88849278(+)	`CTATGC/TCTGTT`	5	--	ds500¹		0	--	--	--	--
rs189747490^1,2		--	88849297(+)	`ATTTAC/TACATT`	5	--	ds500¹		0	--	--	--	--
rs12189668^1,2	C,H,	--	88849365(+)	`AATGCT/CTTTTA`	5	--	ds500¹		4		NS EA	416
rs187020092^1,2		--	88849482(+)	`TAGTCA/TTTAGT`	5	--	ds500¹		0	--	--	--	--
rs80034852^1,2	C,	--	88849598(-)	`ATTACA/CATGAA`	5	--	ut3¹		0	--	--	--	--
rs7738931^1,2	C,F,H,	--	88849725(+)	`CATTGT/GAAATA`	5	--	ut3¹ ese³		12		NS EA NA WA CSA	1314
rs79629362^1,2	C,F,	--	88849912(-)	`TATTAC/ATTTTC`	5	--	ut3¹		1		WA	118
rs74856621^1,2	C,	--	88849999(-)	`GGAAAC/TCTTTT`	5	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CNR1 (88849583 - 88876078 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CNR1
2 CNVs: 52020 53262
Human Gene Mutation Database (HGMD): CNR1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNR1

DNA2.0 Custom Variant and Variant Library Synthesis for CNR1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CNR1 for disorders           About GeneDecksing

OMIM gene information: 114610    OMIM disorders: --

20/121 diseases for CNR1 (see all 121):    About MalaCards

post-traumatic stress disorder pertussis doxorubicin induced cardiomyopathy cannabis dependence

status epilepticus amyotrophic lateral sclerosis substance dependence temporal lobe epilepsy

drug dependence allergic contact dermatitis contact dermatitis pre-eclampsia

anorexia nervosa ectopic pregnancy non-hodgkin lymphoma anxiety disorder

type 2 diabetes mellitus eating disorder major depressive disorder substance abuse

11 diseases from the University of Copenhagen DISEASES database for CNR1:

Cannabis dependence Pain agnosia Schizophrenia Substance abuse

Withdrawal disorder Multiple sclerosis Huntington's disease Amnestic disorder

Parkinson's disease Alcohol dependence Vascular disease

10/92 Novoseek disease relationships for CNR1 gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
obesity	70.1	98	17292652 (4), 20415562 (3), 17027338 (2), 17160086 (2) (see all 68)
multiple sclerosis	54.1	10	16570099 (2), 18501510 (1), 17329437 (1), 20007426 (1) (see all 8)
catalepsy	53.7	5	20211605 (1), 11042139 (1), 9974180 (1), 1806946 (1)
cannabis dependence	53.1	10	19016476 (3), 19443135 (2), 18519829 (1)
huntington disease	48.8	14	10891614 (4), 7944290 (3), 8255419 (2), 15953496 (1) (see all 6)
marijuana abuse	45.9	1	9610678 (1)
neurodegenerative diseases	39.6	3	17950616 (1), 19690173 (1), 19547718 (1)
dyslipidemia	38	2	18773749 (1), 17292044 (1)
metabolic disorder	37.7	8	16510049 (1), 17027338 (1), 17284627 (1), 19497779 (1) (see all 7)
liver fibrosis	36.9	6	19259549 (1), 18578993 (1), 15892090 (1), 17412522 (1) (see all 5)

Genetic Association Database (GAD): CNR1
Human Genome Epidemiology (HuGE) Navigator: CNR1 (99 documents)

Export disorders for CNR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CNR1 gene, integrated from 9 sources (see all 1084):
(articles sorted by number of sources associating them with CNR1)

Utopia: connect your pdf to the dynamic
world of online information

An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. (PubMed id 7876112)^{1, 2, 9} Shire D.... Ferrara P. (1995)
Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene. (PubMed id 15108190)^{1, 4, 9} Gadzicki D....Stuhrmann M. (2004)
Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia. (PubMed id 11204352)^{4, 7, 9} Tsai S.J....Hong C.J. (2000)
Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1. (PubMed id 11803524)^{1, 4, 9} Leroy S....Krebs M.O. (2001)
Association study between cannabinoid receptor gene (CNR1) and pathogenesis and psychotic symptoms of mood disorders. (PubMed id 11353438)^{1, 4, 9} Tsai S.J....Hong C.J. (2001)
(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. (PubMed id 16314880)^{1, 4, 9} Ballon N....Poirier M.F. (2006)
Cannabinoid receptor type 2 gene is associated with human osteoporosis. (PubMed id 16204352)^{1, 4, 9} Karsak M....Zimmer A. (2005)
Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1). (PubMed id 15668727)^{1, 4, 9} Barrero F.J....Garcia Yebenes J. (2005)
Alcoholism-related phenotypes and genetic variants of the CB1 receptor. (PubMed id 14714115)^{1, 4, 9} Preuss U.W....Soyka M. (2003)
Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. (PubMed id 11841893)^{1, 4, 9} Schmidt L.G....Hoehe M.R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1268	HGNC: 2159	AceView: CNR1	Ensembl:ENSG00000118432	euGenes: HUgn1268
ECgene: CNR1	Kegg: 1268	H-InvDB: CNR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CNR1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CNR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CNR1 gene:
Search GeneIP for patents involving CNR1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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cannabinoid receptor 1 (brain)

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CNR1 Gene

cannabinoid receptor 1 (brain)

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