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Aliases for CNR1 Gene

Aliases for CNR1 Gene

  • Cannabinoid Receptor 1 (Brain) 2 3
  • CANN6 3 4
  • CB-R 3 4
  • CNR 3 4
  • CB1 3 4
  • Central Cannabinoid Receptor 3
  • Cannabinoid Receptor 1 3
  • CB1K5 3
  • CB1A 3
  • CB1R 3

External Ids for CNR1 Gene

Previous HGNC Symbols for CNR1 Gene

  • CNR

Previous GeneCards Identifiers for CNR1 Gene

  • GC06M088795
  • GC06M088845
  • GC06M088906
  • GC06M086064
  • GC06M088850

Summaries for CNR1 Gene

Entrez Gene Summary for CNR1 Gene

  • This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for CNR1 Gene

CNR1 (Cannabinoid Receptor 1 (Brain)) is a Protein Coding gene. Diseases associated with CNR1 include cannabis dependence and pertussis. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include drug binding and cannabinoid receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for CNR1 Gene

  • Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.

Tocris Summary for CNR1 Gene

  • The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. They are found mainly in the terminals of central and peripheral neurons where they usually mediate inhibition of neurotransmitter release. They can also be present on some non-neuronal cells, including immune cells.

Gene Wiki entry for CNR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNR1 Gene

Genomics for CNR1 Gene

Regulatory Elements for CNR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNR1 Gene

Start:
88,139,864 bp from pter
End:
88,166,688 bp from pter
Size:
26,825 bases
Orientation:
Minus strand

Genomic View for CNR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNR1 Gene

Proteins for CNR1 Gene

  • Protein details for CNR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21554-CNR1_HUMAN
    Recommended name:
    Cannabinoid receptor 1
    Protein Accession:
    P21554
    Secondary Accessions:
    • B2R9T4
    • E1P512
    • Q13949
    • Q495Z0
    • Q4PLI4
    • Q4VBM6
    • Q5JVL5
    • Q5UB37
    • Q9UNN0

    Protein attributes for CNR1 Gene

    Size:
    472 amino acids
    Molecular mass:
    52858 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CNRIP1.

    Three dimensional structures from OCA and Proteopedia for CNR1 Gene

    Alternative splice isoforms for CNR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNR1 Gene

Proteomics data for CNR1 Gene at MOPED

Post-translational modifications for CNR1 Gene

  • Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts.
  • Glycosylation at Asn77 and Asn83
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CNR1 (Cannabinoid R1/CB1/CNR1)

No data available for DME Specific Peptides for CNR1 Gene

Domains for CNR1 Gene

Gene Families for CNR1 Gene

HGNC:
  • CNR :GPCR / Class A : Cannabinoid receptors
IUPHAR :

Suggested Antigen Peptide Sequences for CNR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21554

UniProtKB/Swiss-Prot:

CNR1_HUMAN :
  • P21554
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CNR1: view

Function for CNR1 Gene

Molecular function for CNR1 Gene

GENATLAS Biochemistry: cannabinoid receptor 1,expressed in brain,testis,located in the eye-ciliary epithelium,corneal epithelium,endothelium of anterior eye retina,inhibiting adenylate cyclaselocated in and/or one cone pedicles and rod spherules,also inhibiting voltage-gated L-type calcium channel current in retinal bipolar cells,putatively involved for endogenouscannaloid system in retinal physiology,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.

Gene Ontology (GO) - Molecular Function for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004949 cannabinoid receptor activity IDA 18761332
GO:0005515 protein binding --
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with CNR1: view
genes like me logo Genes that share phenotypes with CNR1: view

Animal Models for CNR1 Gene

MGI Knock Outs for CNR1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CNR1 Gene

Localization for CNR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNR1 Gene COMPARTMENTS Subcellular localization image for CNR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1718258
GO:0016021 integral component of membrane --
GO:0030424 axon IEA --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with CNR1: view

Pathways for CNR1 Gene

genes like me logo Genes that share pathways with CNR1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1718258
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA 18761332
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with CNR1: view

Compounds for CNR1 Gene

(5) Tocris Compounds for CNR1 Gene

Compound Action Cas Number
(�)-CP 47497 Potent CB1 agonist [70434-82-1]
AM 251 Potent CB1 antagonist; also GPR55 agonist [183232-66-8]
AM 281 Potent, selective CB1 antagonist/inverse agonist [202463-68-1]
PSNCBAM-1 CB1 receptor negative allosteric modulator [877202-74-9]
SR 141716A Selective CB1 receptor antagonist [158681-13-1]

(1) HMDB Compounds for CNR1 Gene

Compound Synonyms Cas Number PubMed IDs
Anandamide
  • Anandamide (20.4, n-6)
94421-68-8

(3) Drugbank Compounds for CNR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dronabinol
1972-08-3 target agonist
Nabilone
51022-71-0 target partial agonist
Rimonabant
  • SR 141716
158681-13-1 target antagonist

(10) IUPHAR Ligand for CNR1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]CP55940 Agonist Full agonist 9.7
CP55940 Agonist Full agonist 9.2
[3H]WIN55212-2 Agonist Full agonist 8.7
rimonabant Antagonist Antagonist 8.2
HU-210 Antagonist Antagonist 7
LY320135 Antagonist Antagonist 6.8
WIN55212-2 Antagonist Antagonist 6.7
cannabinol Agonist Partial agonist 6.5
Delta9-tetrahydrocannabinol Channel blocker None
anandamide Channel blocker None

(97) Novoseek inferred chemical compound relationships for CNR1 Gene

Compound -log(P) Hits PubMed IDs
anandamide 97.1 139
2-arachidonoylglycerol 95.8 128
rimonabant 94.4 102
delta9-tetrahydrocannabinol 93 92
cp55940 92.1 21

(2) PharmGKB related drug/compound annotations for CNR1 Gene

Drug/compound Annotation
clozapine CA
olanzapine CA
genes like me logo Genes that share compounds with CNR1: view

Transcripts for CNR1 Gene

Unigene Clusters for CNR1 Gene

Cannabinoid receptor 1 (brain):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNR1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2: -

Relevant External Links for CNR1 Gene

GeneLoc Exon Structure for
CNR1
ECgene alternative splicing isoforms for
CNR1

Expression for CNR1 Gene

mRNA expression in normal human tissues for CNR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CNR1 Gene

SOURCE GeneReport for Unigene cluster for CNR1 Gene Hs.75110

mRNA Expression by UniProt/SwissProt for CNR1 Gene

P21554-CNR1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with CNR1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CNR1 Gene

Orthologs for CNR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNR1 35
  • 99.58 (n)
  • 100 (a)
CNR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNR1 35
  • 91.17 (n)
  • 97.46 (a)
CNR1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNR1 35
  • 92.66 (n)
  • 98.31 (a)
CNR1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnr1 35
  • 90.54 (n)
  • 97.25 (a)
Cnr1 16
Cnr1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNR1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNR1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnr1 35
  • 90.54 (n)
  • 97.46 (a)
chicken
(Gallus gallus)
Aves CNR1 35
  • 81.95 (n)
  • 93.63 (a)
CNR1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNR1 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cnr1-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cnr1 35
  • 74.12 (n)
  • 83.63 (a)
zebrafish
(Danio rerio)
Actinopterygii cnr1 35
  • 70.61 (n)
  • 74.78 (a)
cnr1 36
  • 70 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for CNR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNR1 Gene

ENSEMBL:
Gene Tree for CNR1 (if available)
TreeFam:
Gene Tree for CNR1 (if available)

Paralogs for CNR1 Gene

Selected SIMAP similar genes for CNR1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CNR1: view

Variants for CNR1 Gene

Sequence variations from dbSNP and Humsavar for CNR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2269 -- 88,141,676(-) GTGCT(A/T)GAGGA utr-variant-3-prime
rs806368 -- 88,140,381(+) TCCCA(C/T)CCGAA utr-variant-3-prime
rs806369 -- 88,146,459(+) TCCCC(C/T)TCATG intron-variant, upstream-variant-2KB
rs806370 -- 88,146,612(+) ATAAA(C/T)AGCCA intron-variant, upstream-variant-2KB
rs806371 -- 88,146,644(+) TAAAT(G/T)TTTGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CNR1 Gene

Variant ID Type Subtype PubMed ID
dgv775n27 CNV Gain 19166990
nsv519365 CNV Gain 19592680
nsv830723 CNV Loss 17160897

Relevant External Links for CNR1 Gene

HapMap Linkage Disequilibrium report
CNR1
Human Gene Mutation Database (HGMD)
CNR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNR1 Gene

Disorders for CNR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (13) Diseases for CNR1 Gene including...

Search for CNR1 Gene in MalaCards »

(92) Novoseek inferred disease relationships for CNR1 Gene

Disease -log(P) Hits PubMed IDs
obesity 70.1 80
multiple sclerosis 54.1 9
catalepsy 53.7 4
cannabis dependence 53.1 6
huntington disease 48.8 12

Relevant External Links for CNR1

Genetic Association Database (GAD)
CNR1
Human Genome Epidemiology (HuGE) Navigator
CNR1
genes like me logo Genes that share disorders with CNR1: view

No data available for UniProtKB/Swiss-Prot for CNR1 Gene

Publications for CNR1 Gene

  1. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. (PMID: 7876112) Shire D. … Ferrara P. (J. Biol. Chem. 1995) 3 4 23
  2. Association study between cannabinoid receptor gene (CNR1) and pathogenesis and psychotic symptoms of mood disorders. (PMID: 11353438) Tsai S.J. … Hong C.J. (Am. J. Med. Genet. 2001) 3 23 48
  3. Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. (PMID: 11841893) Schmidt L.G. … Hoehe M.R. (Drug Alcohol Depend 2002) 3 23 48
  4. Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene. (PMID: 15108190) Gadzicki D. … Stuhrmann M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004) 3 23 48
  5. Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1). (PMID: 15668727) Barrero F.J. … GarcA-a YAcbenes J. (Pharmacogenomics J. 2005) 3 23 48

Products for CNR1 Gene

Sources for CNR1 Gene

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