Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CNR1 Gene

Aliases for CNR1 Gene

  • Cannabinoid Receptor 1 2 3 5
  • Cannabinoid Receptor 1 (Brain) 2 3
  • CANN6 3 4
  • CB-R 3 4
  • CNR 3 4
  • CB1 3 4
  • Central Cannabinoid Receptor 3
  • CB1K5 3
  • CB1A 3
  • CB1R 3

External Ids for CNR1 Gene

Previous HGNC Symbols for CNR1 Gene

  • CNR

Previous GeneCards Identifiers for CNR1 Gene

  • GC06M088795
  • GC06M088845
  • GC06M088906
  • GC06M086064
  • GC06M088850

Summaries for CNR1 Gene

Entrez Gene Summary for CNR1 Gene

  • This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for CNR1 Gene

CNR1 (Cannabinoid Receptor 1) is a Protein Coding gene. Diseases associated with CNR1 include Cannabis Dependence and Cannabis Abuse. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is CNR2.

UniProtKB/Swiss-Prot for CNR1 Gene

  • Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.

Tocris Summary for CNR1 Gene

  • The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons.

Gene Wiki entry for CNR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNR1 Gene

Genomics for CNR1 Gene

Regulatory Elements for CNR1 Gene

Enhancers for CNR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F088008 0.9 Ensembl ENCODE 9.6 +157.7 157695 1.3 ZNF316 PRDM10 TSHZ1 FOS MAFK EMSY TRIM28 SPACA1 CNR1 LOC105377882
GH06F088359 0.2 ENCODE 6.9 -193.6 -193585 1.6 CTCF HLF JUN RAD21 TEAD3 RARA JUND ZNF366 ZNF512 NFE2 CNR1 ACTBP8 GC06P088328 ENSG00000234426
GH06F088376 1.3 Ensembl ENCODE 5.2 -210.0 -210031 0.9 PAF1 ZNF362 JUND SSRP1 POLR2A JUN REST CNR1 ACTBP8 ENSG00000234426 GC06P088328
GH06F088490 0.2 ENCODE 4.9 -324.6 -324594 1.4 ZNF316 CNR1 LOC101928936 LOC105377885
GH06F088379 1.3 FANTOM5 Ensembl ENCODE 2.2 -213.9 -213905 1.9 JUND JUN CEBPB SIN3A FOS NFE2 ACTBP8 CNR1 ENSG00000234426 GC06P088328
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CNR1 on UCSC Golden Path with GeneCards custom track

Promoters for CNR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001221931 145 1601 PKNOX1 WRNIP1 GLI4 ZNF2 GLIS2 KLF7 ZNF202 ZNF263 SP3 ZNF518A
ENSR00001882847 1244 200 CBX8 ZBTB48 RNF2 WRNIP1 CBX2 MLLT1 ZNF501 ZEB2

Genomic Location for CNR1 Gene

Chromosome:
6
Start:
88,139,864 bp from pter
End:
88,166,745 bp from pter
Size:
26,882 bases
Orientation:
Minus strand

Genomic View for CNR1 Gene

Genes around CNR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNR1 Gene

Proteins for CNR1 Gene

  • Protein details for CNR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21554-CNR1_HUMAN
    Recommended name:
    Cannabinoid receptor 1
    Protein Accession:
    P21554
    Secondary Accessions:
    • B2R9T4
    • E1P512
    • Q13949
    • Q495Z0
    • Q4PLI4
    • Q4VBM6
    • Q5JVL5
    • Q5UB37
    • Q9UNN0

    Protein attributes for CNR1 Gene

    Size:
    472 amino acids
    Molecular mass:
    52858 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CNRIP1.

    Three dimensional structures from OCA and Proteopedia for CNR1 Gene

    Alternative splice isoforms for CNR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNR1 Gene

Post-translational modifications for CNR1 Gene

  • Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts.
  • Glycosylation at Asn 77 and Asn 83
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CNR1 (Cannabinoid R1/CB1/CNR1)
  • Cell Signaling Technology (CST) Antibodies for CNR1 (CNR1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CNR1

No data available for DME Specific Peptides for CNR1 Gene

Domains & Families for CNR1 Gene

Gene Families for CNR1 Gene

Suggested Antigen Peptide Sequences for CNR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21554

UniProtKB/Swiss-Prot:

CNR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CNR1: view

Function for CNR1 Gene

Molecular function for CNR1 Gene

GENATLAS Biochemistry:
cannabinoid receptor 1,expressed in brain,testis,located in the eye-ciliary epithelium,corneal epithelium,endothelium of anterior eye retina,inhibiting adenylate cyclaselocated in and/or one cone pedicles and rod spherules,also inhibiting voltage-gated L-type calcium channel current in retinal bipolar cells,putatively involved for endogenouscannaloid system in retinal physiology,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.

Gene Ontology (GO) - Molecular Function for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004949 cannabinoid receptor activity IEA,IDA 18761332
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with CNR1: view
genes like me logo Genes that share phenotypes with CNR1: view

Animal Models for CNR1 Gene

MGI Knock Outs for CNR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CNR1

miRNA for CNR1 Gene

miRTarBase miRNAs that target CNR1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNR1 Gene

Localization for CNR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNR1 Gene COMPARTMENTS Subcellular localization image for CNR1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 1718258
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with CNR1: view

Pathways & Interactions for CNR1 Gene

genes like me logo Genes that share pathways with CNR1: view

Gene Ontology (GO) - Biological Process for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1718258
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA 18761332
genes like me logo Genes that share ontologies with CNR1: view

No data available for SIGNOR curated interactions for CNR1 Gene

Drugs & Compounds for CNR1 Gene

(131) Drugs for CNR1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rimonabant Approved, Investigational Pharma Antagonist, antagonist, Target CB1 receptor antagonist 45
Dronabinol Approved, Illicit Pharma agonist, Target 138
Nabilone Approved, Investigational Pharma Target, partial agonist 18
Cocaine Approved, Illicit Pharma 501
Aripiprazole Approved, Investigational Pharma Antagonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 353

(27) Additional Compounds for CNR1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
(R)-(+)-Methanandamide (in Tocrisolve 100)
157182-49-5
ACEA
220556-69-4
SR 141716A
158681-13-1

(5) Tocris Compounds for CNR1 Gene

Compound Action Cas Number
(R)-(+)-Methanandamide (in Tocrisolve 100) Potent and selective CB1 agonist (in water-soluble emulsion) 157182-49-5
ACEA Potent, highly selective CB1 agonist 220556-69-4
AM 251 Potent CB1 antagonist; also GPR55 agonist 183232-66-8
AM 281 Potent, selective CB1 antagonist/inverse agonist 202463-68-1
SR 141716A Selective CB1 receptor antagonist 158681-13-1

(41) ApexBio Compounds for CNR1 Gene

Compound Action Cas Number
(-)-5'-DMH-CBD 97452-63-6
(±)-SLV 319 CB1 receptor antagonist,potent and selective 362519-49-1
2-Palmitoylglycerol 23470-00-0
AM 1172 Inhibitor of anandamide uptake and FAAH,potent and selective 251908-92-6
AM 281 CB1 antagonist 202463-68-1
AM 404 Anandamide transport inhibitor 198022-70-7
AM1241 Cannabinoid CB2 receptor agonist,potent and selective 444912-48-5
AM251 Potent CB1 antagonist 183232-66-8
Arachidonyl serotonin 187947-37-1
Arvanil 128007-31-8
BML-190 CB2 receptor ligand 2854-32-2
COR 170 1048039-15-1
CP-945598 HCl CB1 antagonist,selective and high affinity 686347-12-6
GW842166X 666260-75-9
Hemopressin (human, mouse) 1314035-51-2
Hemopressin (rat) 568588-77-2
JTE 907 282089-49-0
JWH 073 CB1 receptor agonist 208987-48-8
LY 320135 176977-56-3
MAFP 188404-10-6
MJ 15 944154-76-1
MM-22 956605-71-3
N-Arachidonylglycine 179113-91-8
NIDA 41020 502486-89-7
O-1918 536697-79-7
O-2050
O-2093 439080-01-0
Oleamide 301-02-0
OMDM-2 616884-63-0
Org 27569 Cannabinoid CB1 receptor allosteric modulator 868273-06-7
Otenabant CB1 receptor antagonist 686344-29-6
Palmitoylisopropylamide 189939-61-5
PB-22 Synthetic cannabinoid 1400742-17-7
PF 514273 851728-60-4
Rimonabant CB1 receptor antagonist 168273-06-1
Rimonabant hydrochloride CB1 receptor inverse agonist 158681-13-1
Taranabant 701977-09-5
TC-C 14G 656804-72-7
Tocrifluor T1117 1186195-59-4
UCM 707 390824-20-1
VDM 11 313998-81-1
genes like me logo Genes that share compounds with CNR1: view

Drug Products

Transcripts for CNR1 Gene

Unigene Clusters for CNR1 Gene

Cannabinoid receptor 1 (brain):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNR1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2: -

Relevant External Links for CNR1 Gene

GeneLoc Exon Structure for
CNR1
ECgene alternative splicing isoforms for
CNR1

Expression for CNR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNR1 Gene

This gene is overexpressed in Fetal Brain (35.8) and Frontal cortex (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNR1 Gene



Protein tissue co-expression partners for CNR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNR1 Gene:

CNR1

SOURCE GeneReport for Unigene cluster for CNR1 Gene:

Hs.75110

mRNA Expression by UniProt/SwissProt for CNR1 Gene:

P21554-CNR1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CNR1: view

Primer Products

No data available for mRNA differential expression in normal tissues for CNR1 Gene

Orthologs for CNR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNR1 34 35
  • 99.58 (n)
oppossum
(Monodelphis domestica)
Mammalia CNR1 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNR1 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNR1 34 35
  • 92.66 (n)
cow
(Bos Taurus)
Mammalia CNR1 34 35
  • 91.17 (n)
mouse
(Mus musculus)
Mammalia Cnr1 34 16 35
  • 90.54 (n)
rat
(Rattus norvegicus)
Mammalia Cnr1 34
  • 90.54 (n)
chicken
(Gallus gallus)
Aves CNR1 34 35
  • 81.95 (n)
lizard
(Anolis carolinensis)
Reptilia CNR1 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnr1 34
  • 74.12 (n)
African clawed frog
(Xenopus laevis)
Amphibia cnr1-A 34
zebrafish
(Danio rerio)
Actinopterygii cnr1 34 35
  • 70.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
Species where no ortholog for CNR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNR1 Gene

ENSEMBL:
Gene Tree for CNR1 (if available)
TreeFam:
Gene Tree for CNR1 (if available)

Paralogs for CNR1 Gene

Paralogs for CNR1 Gene

(4) SIMAP similar genes for CNR1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CNR1: view

Variants for CNR1 Gene

Sequence variations from dbSNP and Humsavar for CNR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1049353 -- 88,143,916(-) AGCAC(A/G)GTCAA reference, synonymous-codon
rs1049354 -- 88,143,732(-) GATTG(C/T)CACCA utr-variant-3-prime
rs1049355 -- 88,143,706(-) TTGCT(A/T)ATGTT utr-variant-3-prime
rs1049356 -- 88,143,366(-) TCAGC(A/C)AAACT utr-variant-3-prime
rs10944345 -- 88,161,907(+) ATGCA(C/T)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNR1 Gene

Variant ID Type Subtype PubMed ID
dgv6086n100 CNV gain 25217958
dgv775n27 CNV gain 19166990
esv2763586 CNV gain 21179565
esv3609879 CNV gain 21293372
nsv519365 CNV gain 19592680
nsv604120 CNV loss 21841781
nsv604121 CNV gain 21841781
nsv830723 CNV loss 17160897

Variation tolerance for CNR1 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNR1 Gene

Human Gene Mutation Database (HGMD)
CNR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNR1 Gene

Disorders for CNR1 Gene

MalaCards: The human disease database

(33) MalaCards diseases for CNR1 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CNR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNR1

Genetic Association Database (GAD)
CNR1
Human Genome Epidemiology (HuGE) Navigator
CNR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNR1
genes like me logo Genes that share disorders with CNR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNR1 Gene

Publications for CNR1 Gene

  1. Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosis. (PMID: 19730968) Floreani A. … Bergasa N.V. (J. Gastroenterol. 2010) 3 22 46 64
  2. A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. (PMID: 20107430) Tiwari A.K. … MA1ller D.J. (Neuropsychopharmacology 2010) 3 22 46 64
  3. Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. (PMID: 20010914) Proudnikov D. … Kreek M.J. (Pharmacogenomics J. 2010) 3 22 46 64
  4. Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. (PMID: 19052543) Zuo L. … Gelernter J. (Neuropsychopharmacology 2009) 3 22 46 64
  5. Mutation in CNR1 gene and VEGF expression in esophageal cancer. (PMID: 19366059) Bedoya F. … Vegh I. (Tumori 2009) 3 22 46 64

Products for CNR1 Gene

Sources for CNR1 Gene

Content
Loading form....