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CNR1 Gene

protein-coding   GIFtS: 67
GCID: GC06M088850

Cannabinoid Receptor 1 (Brain)


(Previous symbol: CNR)
  See CNR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cannabinoid Receptor 1 (Brain)1 2     CB1A2
CNR1 2 3     CB1K52
CANN62 3     CB1R2
CB-R2 3     Cannabinoid Receptor 12
CB12 3     Central Cannabinoid Receptor2

External Ids:    HGNC: 21591   Entrez Gene: 12682   Ensembl: ENSG000001184327   OMIM: 1146105   UniProtKB: P215543   

Export aliases for CNR1 gene to outside databases

Previous GC identifers: GC06M088795 GC06M088845 GC06M088906 GC06M086064


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNR1 Gene:
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and
synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the
guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity
in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to
be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by
users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for
this gene. (provided by RefSeq, May 2009)

GeneCards Summary for CNR1 Gene:
CNR1 (cannabinoid receptor 1 (brain)) is a protein-coding gene. Diseases associated with CNR1 include cannabis dependence, and pertussis. GO annotations related to this gene include drug binding and cannabinoid receptor activity. An important paralog of this gene is GPR12.

UniProtKB/Swiss-Prot: CNR1_HUMAN, P21554
Function: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor
for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding

summary for CNR1 Gene:
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor
group of G-protein-coupled receptors that also includes CB2 and GPR55. They are found mainly in the
terminals of central and peripheral neurons where they usually mediate inhibition of neurotransmitter
release. They can also be present on some non-neuronal cells, including immune cells.

Gene Wiki entry for CNR1 (Cannabinoid receptor type 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNR1 gene promoter:
         GR   AP-1   ATF-2   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNR1 promoter sequence
   Search Chromatin IP Primers for CNR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14-q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q14-q15

CNR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNR1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M088850:  view genomic region     (about GC identifiers)

Start:
88,849,583 bp from pter      End:
88,876,078 bp from pter
Size:
26,496 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNR1_HUMAN, P21554 (See protein sequence)
Recommended Name: Cannabinoid receptor 1  
Size: 472 amino acids; 52858 Da
Subunit: Interacts (via C-terminus) with CNRIP1
4 PDB 3D structures from and Proteopedia for CNR1:
1LVQ (3D)        1LVR (3D)        2B0Y (3D)        2KOE (3D)    
Secondary accessions: B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0
Alternative splicing: 3 isoforms:  P21554-1   P21554-2   P21554-3   (Dubious isoform. A putative downstream initiation AUG is used to produce isoform 2 (PubMed:1718258). The use of the first AUG (same as isoform 1) gives a truncated protein of 36 AA)

Explore the universe of human proteins at neXtProt for CNR1: NX_P21554

Explore proteomics data for CNR1 at MOPED

Post-translational modifications: 

  • Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts1
  • Glycosylation2 at Asn77, Asn83
  • Modification sites at PhosphoSitePlus

  • See CNR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001153698.1  NP_001153730.1  NP_001153731.1  NP_057167.2  NP_149421.2  

    ENSEMBL proteins: 
     ENSP00000358513   ENSP00000358511   ENSP00000446819   ENSP00000355418   ENSP00000420188  
     ENSP00000412192   ENSP00000446702   ENSP00000442689   ENSP00000441046   ENSP00000449549  
    Reactome Protein details: P21554

    CNR1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CNR1 Protein
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    Novus Biologicals CNR1 Proteins
    Novus Biologicals CNR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNR1

     
    Search eBioscience for Proteins for CNR1 

     
    antibodies-online proteins for CNR1 (4 products) 

     
    antibodies-online peptides for CNR1

    CNR1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CNR1
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    ThermoFisher Antibody for CNR1
    antibodies-online antibodies for CNR1 (83 products) 

    CNR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for CNR1
    Search eBioscience for ELISAs for CNR1 
    antibodies-online kits for CNR1 (28 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CNR: GPCR / Class A : Cannabinoid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CB1 receptor
    Cannabinoid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000810 Canbinoid_rcpt_1
     IPR002230 Cnbnoid_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P21554

    ProtoNet protein and cluster: P21554

    2 Blocks protein domains:
    IPB000810 Cannabinoid receptor type 1 signature
    IPB002230 Cannabinoid receptor signature


    UniProtKB/Swiss-Prot: CNR1_HUMAN, P21554
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CNR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNR1_HUMAN, P21554
    Function: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor
    for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding

         Genatlas biochemistry entry for CNR1:
    cannabinoid receptor 1,expressed in brain,testis,located in the eye-ciliary epithelium,corneal
    epithelium,endothelium of anterior eye retina,inhibiting adenylate cyclaselocated in and/or one cone pedicles and
    rod spherules,also inhibiting voltage-gated L-type calcium channel current in retinal bipolar cells,putatively
    involved for endogenouscannaloid system in retinal physiology,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004949cannabinoid receptor activity IDA18761332
    GO:0005515protein binding ----
    GO:0008144drug binding IEA--
         
    Find genes that share ontologies with CNR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CNR1:
     Synthetic lethal with imatinib 

         15 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Cnr1):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  growth/size/body 
     homeostasis/metabolism  integument  mortality/aging  nervous system  no phenotypic analysis 
     normal  other  reproductive system  skeleton  taste/olfaction 

    Find genes that share phenotypes with CNR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CNR1: Cnr1tm1Lex Cnr1tm1Ojm Cnr1tm1.1Ltz Cnr1tm1Zim Cnr1tm1Map

       genOway: Develop your customized and physiologically relevant rodent model for CNR1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CNR1 (see all 117):
    hsa-miR-548j hsa-miR-520f hsa-miR-607 hsa-miR-199a-3p hsa-miR-485-3p hsa-miR-128 hsa-miR-342-3p hsa-miR-4267
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CNR1

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    GenScript: all cDNA clones in your preferred vector (see all 6): CNR1 (NM_016083)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNR1

    Cell Line
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    GenScript CNR1-overexpressing Cell Line for Assay
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNR1_HUMAN, P21554: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1718258
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with CNR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNR1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    4G-Beta Gamma Signaling
    CRHR Pathway0.44
    5Ras signaling pathway
    Rap1 signaling pathway0.36


    Find genes that share SuperPaths with CNR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CNR1
        Reelin Pathway (Cajal-Retzius cells)
    CRHR Pathway

    4 BioSystems Pathways for CNR1
        BDNF signaling pathway
    GPCRs, Class A Rhodopsin-like
    N-cadherin signaling events
    Small Ligand GPCRs

    2 Reactome Pathways for CNR1
        G alpha (i) signalling events
    Class A/1 (Rhodopsin-like receptors)


    3 Kegg Pathways  (Kegg details for CNR1):
        Rap1 signaling pathway
    Neuroactive ligand-receptor interaction
    Retrograde endocannabinoid signaling

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CNR1: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat
              Huntington's Disease in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CNR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for CNR1 (P215543 ENSP000003585114) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADORA2AP292743, ENSP000003366304I2D: score=4 STRING: ENSP00000336630
    GNA15P306793, ENSP000002629584I2D: score=2 STRING: ENSP00000262958
    METP085813, ENSP000003172724I2D: score=1 STRING: ENSP00000317272
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    GNAI2P048993, ENSP000003129994I2D: score=3 STRING: ENSP00000312999
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002866positive regulation of acute inflammatory response to antigenic stimulus IEA--
    GO:0006950response to stress ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS1718258
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA18761332

    Find genes that share ontologies with CNR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CNR1
      Browse compounds at ApexBio 

    Compounds for CNR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ACEA Potent, highly selective CB1 agonist [220556-69-4]
    AM 251Potent CB1 antagonist. Also GPR55 agonist[183232-66-8]
    SR 141716ASelective CB1 receptor antagonist[158681-13-1]
    Tocrifluor T1117Novel fluorescent cannabinoid ligand. Fluorescent form of AM 251 (Cat. No. 1117)[1186195-59-4]
    AM 281 Potent, selective CB1 antagonist/inverse agonist [202463-68-1]

    1 HMDB Compound for CNR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    AnandamideAnandamide (20.4, n-6) (see all 13)94421-68-8--

    3 DrugBank Compounds for CNR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Nabilone-- 51022-71-0targetpartial agonist10575283 8864542 17139494 11752352 11698062 8981483
    Dronabinol-- 1972-08-3targetagonist12686391 11204352 17139284 11752352 17016423
    RimonabantSR 141716 (see all 4)158681-13-1targetantagonist11752352 8636122

    10 IUPHAR Ligands for CNR1 (CB1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    HU-210
    AgonistFull agonist9.1 - 10.28819477 7565624
    [3H]CP55940
    AgonistFull agonist8.5 - 9.47775459 8819477 1718258 1331766 8636122 8526880
    CP55940
    AgonistFull agonist8.3 - 9.28819477 7565624 10188977
    WIN55212-2
    AgonistFull agonist6.9 - 8.78819477 7565624 8679694
    rimonabant
    AntagonistAntagonist7.9 - 8.28819477 9435190 8070571 7565624
    [3H]WIN55212-2
    AgonistFull agonist7.8 - 7.99422383 8622639
    Delta9-tetrahydrocannabinol
    AgonistPartial agonist7.3 - 7.48819477 7565624
    anandamide
    AgonistPartial agonist6.3 - 78819477 7565624
    LY320135
    AntagonistAntagonist6.89435190
    cannabinol
    AgonistPartial agonist6 - 6.58819477 7565624

    Selected Novoseek inferred chemical compound relationships for CNR1 gene (see all 97)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anandamide 97.1 430 9658204 (4), 8395053 (4), 9070252 (3), 11425567 (3) (see all 99)
    2-arachidonoylglycerol 95.8 231 17110113 (4), 12711605 (3), 15115777 (3), 16462096 (3) (see all 99)
    rimonabant 94.4 152 15836887 (3), 12690115 (3), 18480689 (2), 16697306 (2) (see all 92)
    delta9-tetrahydrocannabinol 93 145 15749859 (3), 16436496 (3), 14966196 (2), 15385362 (2) (see all 76)
    cp55940 92.1 27 18582849 (2), 12005350 (2), 17558435 (1), 17922024 (1) (see all 19)
    sr144528 90.8 28 16406050 (1), 10716447 (1), 11160626 (1), 14966196 (1) (see all 22)
    am251 88.2 22 16406050 (1), 17270342 (1), 17922024 (1), 18431074 (1) (see all 18)
    cannabidiol 85.6 30 17245363 (5), 15700028 (2), 12443781 (2), 12952947 (2) (see all 15)
    cp55 85 1 12005350 (1)
    palmitoylethanolamide 84.5 10 11485574 (2), 10692582 (1), 18501510 (1), 12570018 (1) (see all 5)

    2 PharmGKB related drug/compound annotations for CNR1 gene    About this table
    Drug/compound PharmGKB Annotation
    clozapineCA  
    olanzapineCA  



    Find genes that share compounds with CNR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNR1 gene (6 alternative transcripts): 
    NM_001160226.1  NM_001160258.1  NM_001160259.1  NM_016083.4  NM_033181.3  NM_001160260.1  

    Unigene Cluster for CNR1:

    Cannabinoid receptor 1 (brain)
    Hs.75110  [show with all ESTs]
    Unigene Representative Sequence: NM_001160258
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369501(uc003pmq.4) ENST00000369499 ENST00000549890(uc021zco.1)
    ENST00000362094 ENST00000468898(uc010kca.3) ENST00000428600 ENST00000551417
    ENST00000535130(uc010kbz.3 uc011dzr.2 uc011dzs.2 uc011dzt.2)
    ENST00000537554 ENST00000549716
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    hsa-miR-548j hsa-miR-520f hsa-miR-607 hsa-miR-199a-3p hsa-miR-485-3p hsa-miR-128 hsa-miR-342-3p hsa-miR-4267
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNR1
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    Additional mRNA sequence: 

    AF107262.1 AK313908.1 AY766182.1 AY995204.1 BC037581.1 BC074811.2 BC074812.2 BC095513.1 
    BC100968.1 BC100969.1 BC100970.1 BC100971.1 BX538191.1 DQ067455.1 X81120.1 X81121.1 

    5 DOTS entries:

    DT.453009  DT.100742992  DT.95094150  DT.121346884  DT.121346886 

    Selected AceView cDNA sequences (see all 74):

    BX538191 AA433954 AA301133 AA806678 AA729349 AA486681 AA729268 NM_033181 
    AA808253 BC074812 AI784573 Z39809 CK823364 BG056131 AI433599 AI168685 
    X81121 NM_016083 Z43750 BM682178 BC074811 R20626 AA232660 AW296383 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CNR1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:        -               
    SP2:              -         


    ECgene alternative splicing isoforms for CNR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAACATAA
    CNR1 Expression
    About this image


    CNR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)
             Cerebellum
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Arteries
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
    CNR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75110

    UniProtKB/Swiss-Prot: CNR1_HUMAN, P21554
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CNR1: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat
              Huntington's Disease in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CNR1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnr11 , 5 cannabinoid receptor 1 (brain)1, 5 90.54(n)1
    97.25(a)1
      4 (16.28 cM)5
    128011  NM_007726.31  NP_031752.11 
     339245935 
    chicken
    (Gallus gallus)
    Aves CNR11 cannabinoid receptor 1 (brain) 81.95(n)
    93.63(a)
      428633  NM_001038652.1  NP_001033741.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNR16
    cannabinoid receptor 1 (brain)
    87(a)
    1 ↔ 1
    1(175942665-175944111)
    African clawed frog
    (Xenopus laevis)
    Amphibia cnr1-A2 cannabinoid receptor 1/CB1 74.64(n)    AY098532.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cnr11 cannabinoid receptor 1 70.61(n)
    74.78(a)
      404209  NM_212820.1  NP_997985.1 


    ENSEMBL Gene Tree for CNR1 (if available)
    TreeFam Gene Tree for CNR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNR1 gene
    GPR122  LPAR22  S1PR12  CNR22  S1PR32  S1PR22  LPAR12  MC1R2  
    MC3R2  MC5R2  MC2R2  GPR32  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    4 SIMAP similar genes for CNR1 using alignment to 6 protein entries:     CNR1_HUMAN (see all proteins):
    CNR2    LPAR1    EDG1    EDG2

    Find genes that share paralogs with CNR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNR1 (see all 571)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471474451,2
    --86092927(+) ATCGAA/TAGATG 4 -- int10--------
    rs1827160591,2
    --88849138(+) TCATTA/GTAAAA 5 -- ds50010--------
    rs1447726001,2
    --88849275(+) GTACTA/GTGTCT 5 -- ds50010--------
    rs1861539801,2
    --88849278(+) CTATGC/TCTGTT 5 -- ds50010--------
    rs1897474901,2
    --88849297(+) ATTTAC/TACATT 5 -- ds50010--------
    rs121896681,2
    C,H--88849365(+) AATGCT/CTTTTA 5 -- ds50014Minor allele frequency- C:0.00NS EA 416
    rs1870200921,2
    --88849482(+) TAGTCA/TTTAGT 5 -- ds50010--------
    rs800348521,2
    C--88849598(-) ATTACA/CATGAA 5 -- ut310--------
    rs764779571,2
    C--88849720(-) ACAATA/GTATTA 5 -- ut310--------
    rs77389311,2
    C,F,H--88849725(+) CATTGT/GAAATA 5 -- ut31 ese312Minor allele frequency- G:0.10NS EA NA WA CSA 1314

    HapMap Linkage Disequilibrium report for CNR1 (88849583 - 88876078 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CNR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830723CNV Loss17160897
    dgv775n27CNV Gain19166990
    nsv519365CNV Gain19592680

    Human Gene Mutation Database (HGMD): CNR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CNR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 114610    OMIM disorders: --

    14 diseases for CNR1:    
    About MalaCards
    cannabis dependence    pertussis    autoimmune encephalitis    status epilepticus
    withdrawal disorder    substance dependence    amnestic disorder    tendinosis
    post-traumatic stress disorder    paroxysmal dyskinesia    spasticity    huntington's disease
    obesity    schizophrenia

    11 diseases from the University of Copenhagen DISEASES database for CNR1:
    Cannabis dependence     Pain agnosia     Schizophrenia     Substance abuse
    Withdrawal disorder     Multiple sclerosis     Huntington's disease     Alcohol dependence
    Amnestic disorder     Parkinson's disease     Vascular disease

    Find genes that share disorders with CNR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CNR1 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 70.1 98 17292652 (4), 20415562 (3), 17027338 (2), 17160086 (2) (see all 68)
    multiple sclerosis 54.1 10 16570099 (2), 18501510 (1), 17329437 (1), 20007426 (1) (see all 8)
    catalepsy 53.7 5 20211605 (1), 11042139 (1), 9974180 (1), 1806946 (1)
    cannabis dependence 53.1 10 19016476 (3), 19443135 (2), 18519829 (1)
    huntington disease 48.8 14 10891614 (4), 7944290 (3), 8255419 (2), 15953496 (1) (see all 6)
    marijuana abuse 45.9 1 9610678 (1)
    neurodegenerative diseases 39.6 3 17950616 (1), 19690173 (1), 19547718 (1)
    dyslipidemia 38 2 18773749 (1), 17292044 (1)
    metabolic disorder 37.7 8 16510049 (1), 17027338 (1), 17284627 (1), 19497779 (1) (see all 7)
    liver fibrosis 36.9 6 19259549 (1), 18578993 (1), 15892090 (1), 17412522 (1) (see all 5)

    Genetic Association Database (GAD): CNR1
    Human Genome Epidemiology (HuGE) Navigator: CNR1 (99 documents)

    Export disorders for CNR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNR1 gene, integrated from 10 sources (see all 1128):
    (articles sorted by number of sources associating them with CNR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. (PubMed id 7876112)1, 2, 9 Shire D.... Ferrara P. (J. Biol. Chem. 1995)
    2. Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. (PubMed id 20010914)1, 4, 9 Proudnikov D....Kreek M.J. (Pharmacogenomics J. 2010)
    3. Single nucleotide change in the cannabinoid receptor-1 (CNR1) gene in colorectal cancer outcome. (PubMed id 19420965)1, 4, 9 Bedoya F....Vegh I. (Oncology 2009)
    4. No association of CNR1 gene variations with susceptibility to schizophrenia. (PubMed id 17881126)1, 4, 9 Seifert J....Stuhrmann M. (Neurosci. Lett. 2007)
    5. A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. (PubMed id 20107430)1, 4, 9 Tiwari A.K....MA1ller D.J. (Neuropsychopharmacology 2010)
    6. Variations in the cannabinoid receptor 1 gene predispose to migraine. (PubMed id 19539700)1, 4, 9 Juhasz G....Bagdy G. (Neurosci. Lett. 2009)
    7. Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene. (PubMed id 15108190)1, 4, 9 Gadzicki D....Stuhrmann M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    8. Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia. (PubMed id 11204352)4, 7, 9 Tsai S.J....Hong C.J. (Psychiatr. Genet. 2000)
    9. Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosis. (PubMed id 19730968)1, 4, 9 Floreani A....Bergasa N.V. (J. Gastroenterol. 2010)
    10. Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index. (PubMed id 19018721)1, 4, 9 Baye T.M....Wilke R.A. (Pharmacogenomics 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1268 HGNC: 2159 AceView: CNR1 Ensembl:ENSG00000118432 euGenes: HUgn1268
    ECgene: CNR1 Kegg: 1268 H-InvDB: CNR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CNR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNR1 gene:
    Search GeneIP for patents involving CNR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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