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Aliases for CNR1 Gene

Aliases for CNR1 Gene

  • Cannabinoid Receptor 1 (Brain) 2 3 5
  • CANN6 3 4
  • CB-R 3 4
  • CNR 3 4
  • CB1 3 4
  • Central Cannabinoid Receptor 3
  • CB1K5 3
  • CB1A 3
  • CB1R 3

External Ids for CNR1 Gene

Previous HGNC Symbols for CNR1 Gene

  • CNR

Previous GeneCards Identifiers for CNR1 Gene

  • GC06M088795
  • GC06M088845
  • GC06M088906
  • GC06M086064
  • GC06M088850

Summaries for CNR1 Gene

Entrez Gene Summary for CNR1 Gene

  • This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for CNR1 Gene

CNR1 (Cannabinoid Receptor 1 (Brain)) is a Protein Coding gene. Diseases associated with CNR1 include Cannabis Dependence and Cannabis Abuse. Among its related pathways are Peptide ligand-binding receptors and Glucose / Energy Metabolism. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for CNR1 Gene

  • Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.

Tocris Summary for CNR1 Gene

  • The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons.

Gene Wiki entry for CNR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNR1 Gene

Genomics for CNR1 Gene

Regulatory Elements for CNR1 Gene

Enhancers for CNR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CNR1 on UCSC Golden Path with GeneCards custom track

Promoters for CNR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNR1 Gene

Chromosome:
6
Start:
88,139,864 bp from pter
End:
88,166,745 bp from pter
Size:
26,882 bases
Orientation:
Minus strand

Genomic View for CNR1 Gene

Genes around CNR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNR1 Gene

Proteins for CNR1 Gene

  • Protein details for CNR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21554-CNR1_HUMAN
    Recommended name:
    Cannabinoid receptor 1
    Protein Accession:
    P21554
    Secondary Accessions:
    • B2R9T4
    • E1P512
    • Q13949
    • Q495Z0
    • Q4PLI4
    • Q4VBM6
    • Q5JVL5
    • Q5UB37
    • Q9UNN0

    Protein attributes for CNR1 Gene

    Size:
    472 amino acids
    Molecular mass:
    52858 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CNRIP1.

    Three dimensional structures from OCA and Proteopedia for CNR1 Gene

    Alternative splice isoforms for CNR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNR1 Gene

Proteomics data for CNR1 Gene at MOPED

Post-translational modifications for CNR1 Gene

  • Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts.
  • Glycosylation at Asn 77 and Asn 83
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CNR1 (Cannabinoid R1/CB1/CNR1)
  • Cell Signaling Technology (CST) Antibodies for CNR1 (CNR1)

No data available for DME Specific Peptides for CNR1 Gene

Domains & Families for CNR1 Gene

Gene Families for CNR1 Gene

Suggested Antigen Peptide Sequences for CNR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21554

UniProtKB/Swiss-Prot:

CNR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CNR1: view

Function for CNR1 Gene

Molecular function for CNR1 Gene

GENATLAS Biochemistry:
cannabinoid receptor 1,expressed in brain,testis,located in the eye-ciliary epithelium,corneal epithelium,endothelium of anterior eye retina,inhibiting adenylate cyclaselocated in and/or one cone pedicles and rod spherules,also inhibiting voltage-gated L-type calcium channel current in retinal bipolar cells,putatively involved for endogenouscannaloid system in retinal physiology,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
genes like me logo Genes that share phenotypes with CNR1: view

Animal Models for CNR1 Gene

MGI Knock Outs for CNR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CNR1

miRNA for CNR1 Gene

miRTarBase miRNAs that target CNR1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNR1 Gene

Localization for CNR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNR1 Gene COMPARTMENTS Subcellular localization image for CNR1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with CNR1: view

Pathways & Interactions for CNR1 Gene

genes like me logo Genes that share pathways with CNR1: view

Gene Ontology (GO) - Biological Process for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA 18761332
GO:0007283 spermatogenesis IEA --
GO:0007413 axonal fasciculation IEA --
genes like me logo Genes that share ontologies with CNR1: view

No data available for SIGNOR curated interactions for CNR1 Gene

Drugs & Compounds for CNR1 Gene

(91) Drugs for CNR1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rimonabant Approved, Investigational Pharma Antagonist, antagonist, Target CB1 receptor antagonist 45
Dronabinol Approved, Illicit Pharma agonist, Target 131
Nabilone Approved, Investigational Pharma Target, partial agonist 17
Cocaine Approved, Illicit Pharma 464
Clozapine Approved Pharma Antagonist Antipsychotic medication, Dopamine antagonist with some D4 selectivity. Also 5-HT2A/2C antagonist 113

(34) Additional Compounds for CNR1 Gene - From: Tocris, Novoseek, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
(R)-(+)-Methanandamide
157182-49-5
ACEA
220556-69-4
ACPA
229021-64-1
Arvanil
128007-31-8

(5) Tocris Compounds for CNR1 Gene

Compound Action Cas Number
(R)-(+)-Methanandamide Potent and selective CB1 agonist 157182-49-5
ACEA Potent, highly selective CB1 agonist 220556-69-4
ACPA Potent, selective CB1 agonist 229021-64-1
Arvanil Potent CB1 and TRPV1 agonist. Also anandamide transport inhibitor 128007-31-8
Oleamide CB1 receptor agonist 301-02-0

(7) ApexBio Compounds for CNR1 Gene

Compound Action Cas Number
AM1241 Cannabinoid CB2 receptor agonist,potent and selective 444912-48-5
AM251 Potent CB1 antagonist 183232-66-8
BML-190 CB2 receptor ligand 2854-32-2
CP-945598 HCl CB1 antagonist,selective and high affinity 686347-12-6
GW842166X 666260-75-9
Org 27569 Cannabinoid CB1 receptor allosteric modulator 868273-06-7
Rimonabant CB1 receptor antagonist 168273-06-1
genes like me logo Genes that share compounds with CNR1: view

Drug Products

Transcripts for CNR1 Gene

Unigene Clusters for CNR1 Gene

Cannabinoid receptor 1 (brain):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNR1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2: -

Relevant External Links for CNR1 Gene

GeneLoc Exon Structure for
CNR1
ECgene alternative splicing isoforms for
CNR1

Expression for CNR1 Gene

mRNA expression in normal human tissues for CNR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNR1 Gene

This gene is overexpressed in Fetal Brain (35.8) and Frontal cortex (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNR1 Gene



SOURCE GeneReport for Unigene cluster for CNR1 Gene Hs.75110

mRNA Expression by UniProt/SwissProt for CNR1 Gene

P21554-CNR1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CNR1: view

Protein tissue co-expression partners for CNR1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CNR1 Gene

Orthologs for CNR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNR1 35
  • 91.17 (n)
  • 97.46 (a)
CNR1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNR1 35
  • 92.66 (n)
  • 98.31 (a)
CNR1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnr1 35
  • 90.54 (n)
  • 97.25 (a)
Cnr1 16
Cnr1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNR1 35
  • 99.58 (n)
  • 100 (a)
CNR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnr1 35
  • 90.54 (n)
  • 97.46 (a)
oppossum
(Monodelphis domestica)
Mammalia CNR1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNR1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNR1 35
  • 81.95 (n)
  • 93.63 (a)
CNR1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNR1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnr1 35
  • 74.12 (n)
  • 83.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia cnr1-A 35
zebrafish
(Danio rerio)
Actinopterygii cnr1 35
  • 70.61 (n)
  • 74.78 (a)
cnr1 36
  • 70 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for CNR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNR1 Gene

ENSEMBL:
Gene Tree for CNR1 (if available)
TreeFam:
Gene Tree for CNR1 (if available)

Paralogs for CNR1 Gene

Paralogs for CNR1 Gene

(4) SIMAP similar genes for CNR1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CNR1: view

Variants for CNR1 Gene

Sequence variations from dbSNP and Humsavar for CNR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1049353 -- 88,143,916(-) AGCAC(A/G)GTCAA reference, synonymous-codon
rs1049354 -- 88,143,732(-) GATTG(C/T)CACCA utr-variant-3-prime
rs1049355 -- 88,143,706(-) TTGCT(A/T)ATGTT utr-variant-3-prime
rs1049356 -- 88,143,366(-) TCAGC(A/C)AAACT utr-variant-3-prime
rs1321360 -- 88,148,625(+) TGCTA(A/G)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNR1 Gene

Variant ID Type Subtype PubMed ID
dgv775n27 CNV Gain 19166990
nsv519365 CNV Gain 19592680
nsv830723 CNV Loss 17160897

Variation tolerance for CNR1 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNR1 Gene

Human Gene Mutation Database (HGMD)
CNR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNR1 Gene

Disorders for CNR1 Gene

MalaCards: The human disease database

(33) MalaCards diseases for CNR1 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CNR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNR1

Genetic Association Database (GAD)
CNR1
Human Genome Epidemiology (HuGE) Navigator
CNR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNR1
genes like me logo Genes that share disorders with CNR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNR1 Gene

Publications for CNR1 Gene

  1. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. (PMID: 7876112) Shire D. … Ferrara P. (J. Biol. Chem. 1995) 3 4 23 67
  2. Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia. (PMID: 11204352) Tsai S.J. … Hong C.J. (Psychiatr. Genet. 2000) 23 25 26
  3. Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A. (PMID: 8636122) Shire D. … Ferrara P. (J. Biol. Chem. 1996) 23 25 26
  4. Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosis. (PMID: 19730968) Floreani A. … Bergasa N.V. (J. Gastroenterol. 2010) 3 23
  5. CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. (PMID: 19942623) Mukhopadhyay P. … Pacher P. (Cardiovasc. Res. 2010) 3 23

Products for CNR1 Gene

Sources for CNR1 Gene

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