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Aliases for CNPY4 Gene

Aliases for CNPY4 Gene

  • Canopy FGF Signaling Regulator 4 2 3
  • PRAT4B 3 6
  • Protein Associated With TLR4 2
  • Canopy 4 Homolog (Zebrafish) 2
  • PRotein Associated With Tlr4 3
  • Protein Canopy Homolog 4 3
  • Canopy 4 Homolog 3
  • MGC40499 6

External Ids for CNPY4 Gene

Previous GeneCards Identifiers for CNPY4 Gene

  • GC07P099556
  • GC07P099718
  • GC07P094352

Summaries for CNPY4 Gene

GeneCards Summary for CNPY4 Gene

CNPY4 (Canopy FGF Signaling Regulator 4) is a Protein Coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is CNPY3.

UniProtKB/Swiss-Prot for CNPY4 Gene

  • Plays a role in the regulation of the cell surface expression of TLR4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY4 Gene

Genomics for CNPY4 Gene

Regulatory Elements for CNPY4 Gene

Genomic Location for CNPY4 Gene

100,119,613 bp from pter
100,125,511 bp from pter
5,899 bases
Plus strand

Genomic View for CNPY4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNPY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY4 Gene

Proteins for CNPY4 Gene

  • Protein details for CNPY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein canopy homolog 4
    Protein Accession:
    Secondary Accessions:
    • Q8WUN9

    Protein attributes for CNPY4 Gene

    248 amino acids
    Molecular mass:
    28310 Da
    Quaternary structure:
    • Interacts with TLR4.

neXtProt entry for CNPY4 Gene

Proteomics data for CNPY4 Gene at MOPED

Post-translational modifications for CNPY4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNPY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CNPY4 Gene

Domains for CNPY4 Gene

Protein Domains for CNPY4 Gene


Suggested Antigen Peptide Sequences for CNPY4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 saposin B-type domain.
  • Belongs to the canopy family.
  • Contains 1 saposin B-type domain.
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY4: view

No data available for Gene Families for CNPY4 Gene

Function for CNPY4 Gene

Molecular function for CNPY4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the cell surface expression of TLR4.

Gene Ontology (GO) - Molecular Function for CNPY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with CNPY4: view

Phenotypes for CNPY4 Gene

GenomeRNAi human phenotypes for CNPY4:
genes like me logo Genes that share phenotypes with CNPY4: view

Animal Model Products

CRISPR Products

miRNA for CNPY4 Gene

miRTarBase miRNAs that target CNPY4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNPY4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CNPY4 Gene

Localization for CNPY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPY4 Gene


Subcellular locations from

Jensen Localization Image for CNPY4 Gene COMPARTMENTS Subcellular localization image for CNPY4 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for CNPY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CNPY4: view

Pathways for CNPY4 Gene

SuperPathways for CNPY4 Gene

No Data Available

Interacting Proteins for CNPY4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8N129-CNPY4_HUMAN ENSP00000262932 for CNPY4 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for CNPY4 Gene


No data available for Pathways by source for CNPY4 Gene

Drugs for CNPY4 Gene

(1) PharmGKB related drug/compound annotations for CNPY4 Gene

Drug/compound Annotation
Tumor necrosis factor alpha (TNF-alpha) inhibitors Clinical Annotation
genes like me logo Genes that share compounds with CNPY4: view

Transcripts for CNPY4 Gene

Unigene Clusters for CNPY4 Gene

Canopy 4 homolog (zebrafish):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNPY4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP4: -

Relevant External Links for CNPY4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNPY4 Gene

mRNA expression in normal human tissues for CNPY4 Gene

Protein differential expression in normal tissues for CNPY4 Gene

This gene is overexpressed in Adrenal (10.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CNPY4 Gene

SOURCE GeneReport for Unigene cluster for CNPY4 Gene Hs.632293

genes like me logo Genes that share expressions with CNPY4: view

Expression partners for CNPY4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNPY4 Gene

Orthologs for CNPY4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNPY4 35
  • 89.64 (n)
  • 87.82 (a)
CNPY4 36
  • 85 (a)
(Canis familiaris)
Mammalia CNPY4 35
  • 88.75 (n)
  • 88.33 (a)
CNPY4 36
  • 81 (a)
(Mus musculus)
Mammalia Cnpy4 35
  • 84.39 (n)
  • 84.39 (a)
Cnpy4 16
Cnpy4 36
  • 80 (a)
(Pan troglodytes)
Mammalia CNPY4 35
  • 97.17 (n)
  • 96.76 (a)
CNPY4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Cnpy4 35
  • 83.96 (n)
  • 84.94 (a)
(Monodelphis domestica)
Mammalia CNPY4 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia CNPY4 36
  • 46 (a)
(Danio rerio)
Actinopterygii cnpy4 35
  • 63.37 (n)
  • 68.02 (a)
cnpy4 36
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3278 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011140 35
  • 54.33 (n)
  • 51.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11577 35
  • 56.26 (n)
  • 53.44 (a)
CG11577 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea C11H1.7 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5145 36
  • 51 (a)
Species with no ortholog for CNPY4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CNPY4 Gene

Gene Tree for CNPY4 (if available)
Gene Tree for CNPY4 (if available)

Paralogs for CNPY4 Gene

Paralogs for CNPY4 Gene

(1) SIMAP similar genes for CNPY4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNPY4: view

Variants for CNPY4 Gene

Sequence variations from dbSNP and Humsavar for CNPY4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1569055 -- 100,123,017(-) CTCTG(C/G)CCCCT intron-variant
rs1880949 -- 100,124,643(-) TCAAC(A/C)CTTAC intron-variant
rs3735240 -- 100,122,735(+) GAAGG(A/G)AGGGG intron-variant
rs7799946 -- 100,122,130(+) agcca(A/G)gattc intron-variant
rs10225723 -- 100,121,943(+) tactc(A/G)ggaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNPY4 Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073

Relevant External Links for CNPY4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPY4 Gene

Disorders for CNPY4 Gene

No disorders were found for CNPY4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CNPY4 Gene

Publications for CNPY4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. (PMID: 16338228) Konno K. … Miyake K. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. Cell surface trafficking of TLR1 is differentially regulated by the chaperones PRAT4A and PRAT4B. (PMID: 22447933) Hart B.E. … Tapping R.I. (J. Biol. Chem. 2012) 3

Products for CNPY4 Gene

Sources for CNPY4 Gene

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