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Aliases for CNPY4 Gene

Aliases for CNPY4 Gene

  • Canopy FGF Signaling Regulator 4 2 3 5
  • Protein Associated With TLR4 2 3
  • Canopy 4 Homolog (Zebrafish) 2
  • Canopy 4 Homolog 3
  • PRAT4B 3

External Ids for CNPY4 Gene

Previous GeneCards Identifiers for CNPY4 Gene

  • GC07P099556
  • GC07P099718
  • GC07P094352

Summaries for CNPY4 Gene

GeneCards Summary for CNPY4 Gene

CNPY4 (Canopy FGF Signaling Regulator 4) is a Protein Coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is CNPY3.

UniProtKB/Swiss-Prot for CNPY4 Gene

  • Plays a role in the regulation of the cell surface expression of TLR4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY4 Gene

Genomics for CNPY4 Gene

Regulatory Elements for CNPY4 Gene

Promoters for CNPY4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNPY4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNPY4 Gene

Chromosome:
7
Start:
100,119,613 bp from pter
End:
100,125,511 bp from pter
Size:
5,899 bases
Orientation:
Plus strand

Genomic View for CNPY4 Gene

Genes around CNPY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNPY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNPY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY4 Gene

Proteins for CNPY4 Gene

  • Protein details for CNPY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N129-CNPY4_HUMAN
    Recommended name:
    Protein canopy homolog 4
    Protein Accession:
    Q8N129
    Secondary Accessions:
    • Q8WUN9

    Protein attributes for CNPY4 Gene

    Size:
    248 amino acids
    Molecular mass:
    28310 Da
    Quaternary structure:
    • Interacts with TLR4.

neXtProt entry for CNPY4 Gene

Proteomics data for CNPY4 Gene at MOPED

Post-translational modifications for CNPY4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNPY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CNPY4 Gene

Domains & Families for CNPY4 Gene

Protein Domains for CNPY4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNPY4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N129

UniProtKB/Swiss-Prot:

CNPY4_HUMAN :
  • Contains 1 saposin B-type domain.
  • Belongs to the canopy family.
Domain:
  • Contains 1 saposin B-type domain.
Family:
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY4: view

No data available for Gene Families for CNPY4 Gene

Function for CNPY4 Gene

Molecular function for CNPY4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the cell surface expression of TLR4.
genes like me logo Genes that share phenotypes with CNPY4: view

Animal Model Products

CRISPR Products

miRNA for CNPY4 Gene

miRTarBase miRNAs that target CNPY4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNPY4 Gene

Localization for CNPY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPY4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNPY4 Gene COMPARTMENTS Subcellular localization image for CNPY4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2

No data available for Gene Ontology (GO) - Cellular Components for CNPY4 Gene

Pathways & Interactions for CNPY4 Gene

SuperPathways for CNPY4 Gene

No Data Available

Interacting Proteins for CNPY4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262932%0d%0a9606.ENSP00000363089%0d%0a
Selected Interacting proteins: ENSP00000262932 Q8N129-CNPY4_HUMAN for CNPY4 Gene via STRING MINT I2D

Gene Ontology (GO) - Biological Process for CNPY4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CNPY4 Gene

Drugs & Compounds for CNPY4 Gene

(1) Drugs for CNPY4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with CNPY4: view

Transcripts for CNPY4 Gene

Unigene Clusters for CNPY4 Gene

Canopy 4 homolog (zebrafish):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3:
SP4: -
SP5:

Relevant External Links for CNPY4 Gene

GeneLoc Exon Structure for
CNPY4
ECgene alternative splicing isoforms for
CNPY4

Expression for CNPY4 Gene

mRNA expression in normal human tissues for CNPY4 Gene

Protein differential expression in normal tissues from HIPED for CNPY4 Gene

This gene is overexpressed in Adrenal (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNPY4 Gene



SOURCE GeneReport for Unigene cluster for CNPY4 Gene Hs.632293

genes like me logo Genes that share expression patterns with CNPY4: view

Protein tissue co-expression partners for CNPY4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNPY4 Gene

Orthologs for CNPY4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNPY4 35
  • 89.64 (n)
  • 87.82 (a)
CNPY4 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNPY4 35
  • 88.75 (n)
  • 88.33 (a)
CNPY4 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnpy4 35
  • 84.39 (n)
  • 84.39 (a)
Cnpy4 16
Cnpy4 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNPY4 35
  • 97.17 (n)
  • 96.76 (a)
CNPY4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnpy4 35
  • 83.96 (n)
  • 84.94 (a)
oppossum
(Monodelphis domestica)
Mammalia CNPY4 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNPY4 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cnpy4 35
  • 63.37 (n)
  • 68.02 (a)
cnpy4 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3278 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011140 35
  • 54.33 (n)
  • 51.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11577 35
  • 56.26 (n)
  • 53.44 (a)
CG11577 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C11H1.7 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5145 36
  • 51 (a)
OneToOne
Species with no ortholog for CNPY4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CNPY4 Gene

ENSEMBL:
Gene Tree for CNPY4 (if available)
TreeFam:
Gene Tree for CNPY4 (if available)

Paralogs for CNPY4 Gene

Paralogs for CNPY4 Gene

(1) SIMAP similar genes for CNPY4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNPY4: view

Variants for CNPY4 Gene

Sequence variations from dbSNP and Humsavar for CNPY4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs60551236 - 100,124,550(+) TTGTG(A/C/G)GAGAC reference, missense
rs1569055 -- 100,123,017(-) CTCTG(C/G)CCCCT intron-variant
rs1880949 -- 100,124,643(-) TCAAC(A/C)CTTAC intron-variant
rs3735240 -- 100,122,735(+) GAAGG(A/G)AGGGG intron-variant
rs7799946 -- 100,122,130(+) agcca(A/G)gattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNPY4 Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073

Variation tolerance for CNPY4 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNPY4 Gene

HapMap Linkage Disequilibrium report
CNPY4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPY4 Gene

Disorders for CNPY4 Gene

Relevant External Links for CNPY4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNPY4

No disorders were found for CNPY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNPY4 Gene

Publications for CNPY4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. (PMID: 16338228) Konno K. … Miyake K. (Biochem. Biophys. Res. Commun. 2006) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Cell surface trafficking of TLR1 is differentially regulated by the chaperones PRAT4A and PRAT4B. (PMID: 22447933) Hart B.E. … Tapping R.I. (J. Biol. Chem. 2012) 3
  5. [Changes and significance for regulatory factors for signal pathways of Toll-like receptors in immunological pathogenesis of Kawasaki disease]. (PMID: 18353240) Wang G.B. … Yang W.G. (Zhonghua Er Ke Za Zhi 2008) 23

Products for CNPY4 Gene

Sources for CNPY4 Gene

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