CNPY4 Gene
protein-coding GIFtS: 50
GCID: GC07P099718
|
|
canopy 4 homolog (zebrafish)
| |
Aliases
for CNPY4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Canopy 4 Homolog (Zebrafish)1 2 | | PRAT4B1 2 5 | | MGC404991 5 | | PRotein Associated With Tlr42 | | Protein Canopy Homolog 42 |
Export aliases for CNPY4 gene to outside databasesPrevious GC identifers: GC07P099556 GC07P094352 |
Summaries
for CNPY4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CNPY4_HUMAN, Q8N129Function: Plays a role in the regulation of the cell surface expression of TLR4
|
Genomic Views
for CNPY4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CNPY4 gene promoter:
Max1 C/EBPbeta Elk-1 FOXF2 MyoD Tal-1beta E47 Pax-4a c-Myc ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNPY4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNPY4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1CNPY4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P099718: view genomic region
(about GC identifiers)
Start:
|
99,717,236 bp from pter |
End:
|
99,723,134 bp from pter |
Size:
|
5,899 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 99,077,384-99,083,250 |
|
Proteins
for CNPY4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CNPY4_HUMAN, Q8N129 (See
protein sequence)Recommended Name: Protein canopy homolog 4 precursor Size: 248 amino acids; 28310 Da
Subunit: Interacts with TLR4 (By similarity)
Subcellular location: Secreted (Potential)
Secondary accessions: Q8WUN9Explore the universe of human proteins at neXtProt for CNPY4: NX_Q8N129
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N129
CNPY4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689968.1
ENSEMBL proteins: ENSP00000262932
Human Recombinant Protein Products for CNPY4:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CNPY4 for ontologies About GeneDecksing
CNPY4 Antibody Products:
Assay Products for CNPY4: |
Protein
Domains /
Families
for CNPY4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CNPY4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N129ProtoNet protein and cluster: Q8N129 UniProtKB/Swiss-Prot: CNPY4_HUMAN, Q8N129Similarity: Belongs to the canopy familySimilarity: Contains 1 saposin B-type domain |
Function
for CNPY4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CNPY4_HUMAN, Q8N129Function: Plays a role in the regulation of the cell surface expression of TLR4 Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005102 | receptor binding |
IEA | -- |
CNPY4 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for CNPY4:
1 MGI phenotypic allele  for Cnpy4 (no phenotypes)
CNPY4 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Cnpy4tm1Lex for CNPY4
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNPY4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNPY4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNPY4 |
|
Pathways & Interactions
for CNPY4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNPY4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for CNPY4 (Q8N1292, 3 ENSP000002629324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CNPY4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CNPY4
Search CenterWatch for drugs/clinical trials and news about CNPY4
|
Transcripts
for CNPY4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CNPY4 gene: NM_152755.1 Unigene Cluster for CNPY4: Canopy 4 homolog (zebrafish) Hs.632293 [show with all ESTs]Unigene Representative Sequence: BC0323395 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262932(uc003uto.3) ENST00000470153 ENST00000483756 ENST00000480692
ENST00000462193
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNPY4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNPY4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CNPY4 (NM_152755) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNPY4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNPY4 |
Additional cDNA sequence: AK075537.1 AY359100.1 BC019903.1 BC032339.1 7 DOTS entries: DT.451742 DT.40224165 DT.70104776 DT.100714390 DT.121080724 DT.40129889 DT.121080618 24/77 AceView cDNA sequences (see all 77): AA661635 AA931966 AY359100 AA457490 AI870866 AK075537 BQ288055 BI488499 BC032339 BM565554 AW513265 AA826675 BM473025 BU191647 BQ417505 CA422773 BM928528 AI199995 AA469081 BQ189264 NM_152755 BG231683 BU845063 AA989066
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CNPY4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CNPY4
|
Expression
for CNPY4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNPY4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTGGAGTT
About this image
See CNPY4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNPY4
SOURCE GeneReport for Unigene cluster: Hs.632293
SABiosciences Custom PCR Arrays for CNPY4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNPY4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNPY4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNPY4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNPY4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNPY4 |
Orthologs
for CNPY4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CNPY4 gene from 3/17 species (see all 17) About this table
ENSEMBL Gene Tree for CNPY4 (if available)
TreeFam Gene Tree for CNPY4 (if available) |
Paralogs
for CNPY4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CNPY4 gene
- CNPY32
1 SIMAP similar gene for CNPY4 using alignment to 1 protein entry: CNPY4_HUMAN:CNPY3
CNPY4 for paralogs About GeneDecksing
|
Genomic Variants
for CNPY4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CNPY4 (99717236 - 99723134 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CNPY4
1 CNV: 2104 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNPY4 |
|
Disorders
/ Diseases
for CNPY4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CNPY4 for disorders About GeneDecksing
OMIM gene information: 610047
OMIM disorders: --
1  disease for CNPY4: About MalaCardskawasaki disease
Export disorders for CNPY4 gene to outside databases
|
Publications
for CNPY4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CNPY4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CNPY4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. (PubMed id 16338228)1, 2, 9 Konno K.... Miyake K. (2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Cell surface trafficking of TLR1 is differentially reg ulated by the chaperones PRAT4A and PRAT4B. (PubMed id 22447933)1 Hart B.E. and Tapping R.I. (2012)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- [Changes and significance for regulatory factors for signal pathways of Toll-like receptors in immunological pathogenesis of Kawasaki disease] (PubMed id 18353240)9 Wang G.B....Yang W.G. (2008)
|
External Searches for CNPY4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CNPY4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CNPY4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CNPY4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CNPY4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CNPY4 gene:
Search GeneIP for patents involving CNPY4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CNPY4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | CNPY4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNPY4 |
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