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Aliases for CNPY3 Gene

Aliases for CNPY3 Gene

  • Canopy FGF Signaling Regulator 3 2 3 5
  • Trinucleotide Repeat-Containing Gene 5 Protein 3 4
  • Expanded Repeat-Domain Protein CAG/CTG 5 3 4
  • Protein Associated With TLR4 3 4
  • CTG Repeat Protein 4a 3 4
  • PRAT4A 3 4
  • TNRC5 3 4
  • ERDA5 3 4
  • Protein Associated With Toll-Like Receptor 4A 3
  • Trinucleotide Repeat Containing 5 2
  • Canopy 3 Homolog (Zebrafish) 2
  • CAG Repeat Containing 3
  • CAG4A 3
  • CTG4A 4

External Ids for CNPY3 Gene

Previous HGNC Symbols for CNPY3 Gene

  • TNRC5

Previous GeneCards Identifiers for CNPY3 Gene

  • GC06P043004
  • GC06P042897
  • GC06P042614
  • GC06P042901

Summaries for CNPY3 Gene

Entrez Gene Summary for CNPY3 Gene

  • This gene encodes a protein that binds members of the toll-like receptor protein family and functions as a chaperone to aid in folding and export of these proteins. Alternative splicing results in multiple transcript variants. Naturally occuring readthrough transcription occurs between this locus and the downstream GNMT (glycine N-methyltransferase) gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]

GeneCards Summary for CNPY3 Gene

CNPY3 (Canopy FGF Signaling Regulator 3) is a Protein Coding gene. Diseases associated with CNPY3 include swayback. Among its related pathways are Immune System and MyD88 cascade initiated on plasma membrane. GO annotations related to this gene include receptor binding. An important paralog of this gene is CNPY4.

UniProtKB/Swiss-Prot for CNPY3 Gene

  • Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY3 Gene

Genomics for CNPY3 Gene

Regulatory Elements for CNPY3 Gene

Promoters for CNPY3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNPY3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNPY3 Gene

Chromosome:
6
Start:
42,929,122 bp from pter
End:
42,939,287 bp from pter
Size:
10,166 bases
Orientation:
Plus strand

Genomic View for CNPY3 Gene

Genes around CNPY3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNPY3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNPY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY3 Gene

Proteins for CNPY3 Gene

  • Protein details for CNPY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT09-CNPY3_HUMAN
    Recommended name:
    Protein canopy homolog 3
    Protein Accession:
    Q9BT09
    Secondary Accessions:
    • O15412
    • Q0P6I2
    • Q8NF54
    • Q8WTU8
    • Q9P0F2

    Protein attributes for CNPY3 Gene

    Size:
    278 amino acids
    Molecular mass:
    30748 Da
    Quaternary structure:
    • Interacts with HSP90B1; this interaction is disrupted in the presence of ATP. Interacts with TLR1, TLR2, TLR4 and TLR9 (By similarity). Strongest interaction with TLR4 (By similarity).
    SequenceCaution:
    • Sequence=AAB91442.1; Type=Frameshift; Positions=109; Evidence={ECO:0000305}; Sequence=AAF28907.1; Type=Frameshift; Positions=252; Evidence={ECO:0000305};

    Alternative splice isoforms for CNPY3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNPY3 Gene

Proteomics data for CNPY3 Gene at MOPED

Post-translational modifications for CNPY3 Gene

  • Glycosylation at Asn 153 and Thr 271
  • Modification sites at PhosphoSitePlus

Other Protein References for CNPY3 Gene

Antibody Products

No data available for DME Specific Peptides for CNPY3 Gene

Domains & Families for CNPY3 Gene

Gene Families for CNPY3 Gene

Protein Domains for CNPY3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNPY3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BT09

UniProtKB/Swiss-Prot:

CNPY3_HUMAN :
  • Contains 1 saposin B-type domain.
  • Belongs to the canopy family.
Domain:
  • Contains 1 saposin B-type domain.
Family:
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY3: view

Function for CNPY3 Gene

Molecular function for CNPY3 Gene

UniProtKB/Swiss-Prot Function:
Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity).
genes like me logo Genes that share phenotypes with CNPY3: view

Animal Models for CNPY3 Gene

MGI Knock Outs for CNPY3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CNPY3

miRNA for CNPY3 Gene

miRTarBase miRNAs that target CNPY3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNPY3 Gene

Localization for CNPY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPY3 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNPY3 Gene COMPARTMENTS Subcellular localization image for CNPY3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytosol 2
endosome 2
lysosome 2
nucleus 2
vacuole 2

No data available for Gene Ontology (GO) - Cellular Components for CNPY3 Gene

Pathways & Interactions for CNPY3 Gene

genes like me logo Genes that share pathways with CNPY3: view

Pathways by source for CNPY3 Gene

Interacting Proteins for CNPY3 Gene

Gene Ontology (GO) - Biological Process for CNPY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CNPY3: view

No data available for SIGNOR curated interactions for CNPY3 Gene

Drugs & Compounds for CNPY3 Gene

No Compound Related Data Available

Transcripts for CNPY3 Gene

Unigene Clusters for CNPY3 Gene

Canopy 3 homolog (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6:
SP7: - - - - - - - - - -
SP8: - - -
SP9: - - -
SP10: - - -
SP11: - - - -
SP12: - - - - - -
SP13:

Relevant External Links for CNPY3 Gene

GeneLoc Exon Structure for
CNPY3
ECgene alternative splicing isoforms for
CNPY3

Expression for CNPY3 Gene

mRNA expression in normal human tissues for CNPY3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNPY3 Gene

This gene is overexpressed in Whole Blood (x10.2).

Protein differential expression in normal tissues from HIPED for CNPY3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CNPY3 Gene



SOURCE GeneReport for Unigene cluster for CNPY3 Gene Hs.414099

genes like me logo Genes that share expression patterns with CNPY3: view

Protein tissue co-expression partners for CNPY3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CNPY3 Gene

Orthologs for CNPY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNPY3 35
  • 90.12 (n)
  • 94.65 (a)
CNPY3 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNPY3 35
  • 90.9 (n)
  • 94.46 (a)
CNPY3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnpy3 35
  • 85.14 (n)
  • 86.96 (a)
Cnpy3 16
Cnpy3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNPY3 35
  • 99.4 (n)
  • 99.64 (a)
CNPY3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnpy3 35
  • 85.99 (n)
  • 88.04 (a)
oppossum
(Monodelphis domestica)
Mammalia CNPY3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNPY3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858990 35
  • 75.8 (n)
  • 77.17 (a)
CNPY3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNPY3 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18156 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18916 35
tnrc5 35
  • 65.43 (n)
  • 66.26 (a)
tnrc5 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11577 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C11H1.7 35
  • 48.96 (n)
  • 36.87 (a)
C11H1.7 36
  • 31 (a)
OneToMany
Species with no ortholog for CNPY3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CNPY3 Gene

ENSEMBL:
Gene Tree for CNPY3 (if available)
TreeFam:
Gene Tree for CNPY3 (if available)

Paralogs for CNPY3 Gene

Paralogs for CNPY3 Gene

(1) SIMAP similar genes for CNPY3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNPY3: view

Variants for CNPY3 Gene

Sequence variations from dbSNP and Humsavar for CNPY3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_037731 -
VAR_037732 -
rs1053538 -- 42,936,025(+) CACCT(C/G)GGTGG intron-variant
rs1053539 -- 42,936,028(+) CTCGG(G/T)GGGAG intron-variant
rs1160867 -- 42,929,213(-) GACCC(-/AG/GAG)GAGAA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CNPY3 Gene

Variant ID Type Subtype PubMed ID
nsv830651 CNV Loss 17160897

Variation tolerance for CNPY3 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.40; 85.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNPY3 Gene

HapMap Linkage Disequilibrium report
CNPY3
Human Gene Mutation Database (HGMD)
CNPY3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPY3 Gene

Disorders for CNPY3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CNPY3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
swayback
  • swayback of sheep
- elite association - COSMIC cancer census association via MalaCards
Search CNPY3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNPY3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNPY3
genes like me logo Genes that share disorders with CNPY3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNPY3 Gene

Publications for CNPY3 Gene

  1. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis R.L. … Ross C.A. (Hum. Genet. 1997) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Cell surface trafficking of TLR1 is differentially regulated by the chaperones PRAT4A and PRAT4B. (PMID: 22447933) Hart B.E. … Tapping R.I. (J. Biol. Chem. 2012) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. (PMID: 20865800) Liu B. … Li Z. (Nat. Commun. 2010) 3

Products for CNPY3 Gene

Sources for CNPY3 Gene

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