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Aliases for CNPY3 Gene

Aliases for CNPY3 Gene

  • Canopy FGF Signaling Regulator 3 2 3
  • PRAT4A 3 4 6
  • TNRC5 3 4 6
  • ERDA5 3 4 6
  • Trinucleotide Repeat-Containing Gene 5 Protein 3 4
  • Expanded Repeat-Domain Protein CAG/CTG 5 3 4
  • Trinucleotide Repeat Containing 5 2 3
  • CTG Repeat Protein 4a 3 4
  • Protein Associated With Toll-Like Receptor 4A 3
  • Expanded Repeat Domain, CAG/CTG 5 3
  • PRotein Associated With Tlr4 3
  • Canopy 3 Homolog (Zebrafish) 2
  • Protein Associated With TLR4 4
  • Protein Canopy Homolog 3 3
  • CAG Repeat Containing 3
  • Canopy 3 Homolog 3
  • CAG4A 3
  • CTG4A 4

External Ids for CNPY3 Gene

Previous HGNC Symbols for CNPY3 Gene

  • TNRC5

Previous GeneCards Identifiers for CNPY3 Gene

  • GC06P043004
  • GC06P042897
  • GC06P042614
  • GC06P042901

Summaries for CNPY3 Gene

Entrez Gene Summary for CNPY3 Gene

  • PRAT4A is associated with the immature form of TLR4 (MIM 603030) and regulates its cell surface expression (Wakabayashi et al., 2006 [PubMed 16849487]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CNPY3 Gene

CNPY3 (Canopy FGF Signaling Regulator 3) is a Protein Coding gene. Diseases associated with CNPY3 include swayback. Among its related pathways are Trafficking and processing of endosomal TLR. GO annotations related to this gene include receptor binding. An important paralog of this gene is CNPY4.

UniProtKB/Swiss-Prot for CNPY3 Gene

  • Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY3 Gene

Genomics for CNPY3 Gene

Regulatory Elements for CNPY3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNPY3 Gene

42,929,122 bp from pter
42,947,757 bp from pter
18,636 bases
Plus strand

Genomic View for CNPY3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNPY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY3 Gene

Proteins for CNPY3 Gene

  • Protein details for CNPY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein canopy homolog 3
    Protein Accession:
    Secondary Accessions:
    • O15412
    • Q0P6I2
    • Q8NF54
    • Q8WTU8
    • Q9P0F2

    Protein attributes for CNPY3 Gene

    278 amino acids
    Molecular mass:
    30748 Da
    Quaternary structure:
    • Interacts with HSP90B1; this interaction is disrupted in the presence of ATP. Interacts with TLR1, TLR2, TLR4 and TLR9 (By similarity). Strongest interaction with TLR4 (By similarity).
    • Sequence=AAB91442.1; Type=Frameshift; Positions=109; Evidence={ECO:0000305}; Sequence=AAF28907.1; Type=Frameshift; Positions=252; Evidence={ECO:0000305};

    Alternative splice isoforms for CNPY3 Gene


neXtProt entry for CNPY3 Gene

Proteomics data for CNPY3 Gene at MOPED

Post-translational modifications for CNPY3 Gene

  • Glycosylation at Asn153 and Thr271
  • Modification sites at PhosphoSitePlus

Other Protein References for CNPY3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CNPY3 Gene

Domains for CNPY3 Gene

Gene Families for CNPY3 Gene

  • TNRC :Trinucleotide (CAG) repeat containing

Protein Domains for CNPY3 Gene


Suggested Antigen Peptide Sequences for CNPY3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BT09
  • Contains 1 saposin B-type domain.
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY3: view

Function for CNPY3 Gene

Molecular function for CNPY3 Gene

UniProtKB/Swiss-Prot Function: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity).

Gene Ontology (GO) - Molecular Function for CNPY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with CNPY3: view
genes like me logo Genes that share phenotypes with CNPY3: view

Animal Models for CNPY3 Gene

MGI Knock Outs for CNPY3:

Animal Model Products

CRISPR Products

miRNA for CNPY3 Gene

miRTarBase miRNAs that target CNPY3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CNPY3 Gene

Localization for CNPY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPY3 Gene

Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for CNPY3 Gene COMPARTMENTS Subcellular localization image for CNPY3 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
endosome 2
lysosome 2
vacuole 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CNPY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with CNPY3: view

Pathways for CNPY3 Gene

genes like me logo Genes that share pathways with CNPY3: view

Pathways by source for CNPY3 Gene

1 Reactome pathway for CNPY3 Gene

Interacting Proteins for CNPY3 Gene

Gene Ontology (GO) - Biological Process for CNPY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with CNPY3: view

Transcripts for CNPY3 Gene

Unigene Clusters for CNPY3 Gene

Canopy 3 homolog (zebrafish):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNPY3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP7: - - - - - - - - - -
SP8: - - -
SP9: - - -
SP10: - - -
SP11: - - - -
SP12: - - - - - -

Relevant External Links for CNPY3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNPY3 Gene

mRNA expression in normal human tissues for CNPY3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNPY3 Gene

This gene is overexpressed in Whole Blood (10.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CNPY3 Gene

SOURCE GeneReport for Unigene cluster for CNPY3 Gene Hs.414099

genes like me logo Genes that share expressions with CNPY3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CNPY3 Gene

Orthologs for CNPY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNPY3 35
  • 99.4 (n)
  • 99.64 (a)
CNPY3 36
  • 100 (a)
(Bos Taurus)
Mammalia CNPY3 35
  • 90.12 (n)
  • 94.65 (a)
CNPY3 36
  • 83 (a)
(Canis familiaris)
Mammalia CNPY3 35
  • 90.9 (n)
  • 94.46 (a)
CNPY3 36
  • 92 (a)
(Mus musculus)
Mammalia Cnpy3 35
  • 85.14 (n)
  • 86.96 (a)
Cnpy3 16
Cnpy3 36
  • 88 (a)
(Monodelphis domestica)
Mammalia CNPY3 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia CNPY3 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Cnpy3 35
  • 85.99 (n)
  • 88.04 (a)
(Gallus gallus)
Aves CNPY3 36
  • 69 (a)
LOC100858990 35
  • 75.8 (n)
  • 77.17 (a)
(Anolis carolinensis)
Reptilia CNPY3 36
  • 67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18156 35
(Danio rerio)
Actinopterygii Dr.18916 35
tnrc5 35
  • 65.43 (n)
  • 66.26 (a)
tnrc5 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11577 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea C11H1.7 35
  • 48.96 (n)
  • 36.87 (a)
C11H1.7 36
  • 31 (a)
Species with no ortholog for CNPY3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CNPY3 Gene

Gene Tree for CNPY3 (if available)
Gene Tree for CNPY3 (if available)

Paralogs for CNPY3 Gene

Paralogs for CNPY3 Gene

Selected SIMAP similar genes for CNPY3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNPY3: view

Variants for CNPY3 Gene

Sequence variations from dbSNP and Humsavar for CNPY3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14499 -- 42,939,113(-) GTCTC(C/T)GGAGG utr-variant-3-prime, intron-variant
rs1048217 -- 42,929,376(+) ATTGG(C/T)TGCGC utr-variant-5-prime, upstream-variant-2KB, nc-transcript-variant
rs1048330 -- 42,939,184(+) CCTCT(C/T)TGCTT utr-variant-3-prime, intron-variant
rs1048349 -- 42,939,205(+) TGGAC(A/C)CCTTG utr-variant-3-prime, intron-variant
rs1048360 -- 42,939,215(+) GCACT(C/T)TGCCT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNPY3 Gene

Variant ID Type Subtype PubMed ID
nsv830651 CNV Loss 17160897

Relevant External Links for CNPY3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPY3 Gene

Disorders for CNPY3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CNPY3 Gene including...

Search for CNPY3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CNPY3 Gene

genes like me logo Genes that share disorders with CNPY3: view

No data available for UniProtKB/Swiss-Prot for CNPY3 Gene

Publications for CNPY3 Gene

  1. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis R.L. … Ross C.A. (Hum. Genet. 1997) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4. (PMID: 16849487) Wakabayashi Y. … Miyake K. (J. Immunol. 2006) 3
  5. Cell surface trafficking of TLR1 is differentially regulated by the chaperones PRAT4A and PRAT4B. (PMID: 22447933) Hart B.E. … Tapping R.I. (J. Biol. Chem. 2012) 3

Products for CNPY3 Gene

Sources for CNPY3 Gene

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