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CNPY3 Gene

protein-coding   GIFtS: 58
GCID: GC06P042901

Canopy FGF Signaling Regulator 3

(Previous names: trinucleotide repeat containing 5, canopy 3 homolog (zebrafish))
(Previous symbol: TNRC5)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Canopy FGF Signaling Regulator 31 2     Canopy 3 Homolog (Zebrafish)1
TNRC51 2 3 5     CAG4A2
ERDA52 3 5     CAG Repeat Containing2
PRAT4A2 3 5     Canopy 3 Homolog2
Trinucleotide Repeat Containing 51 2     Expanded Repeat Domain, CAG/CTG 52
Expanded Repeat-Domain Protein CAG/CTG 52 3     Protein Associated With Toll-Like Receptor 4A2
Protein Associated With TLR42 3     Protein Canopy Homolog 32
Trinucleotide Repeat-Containing Gene 5 Protein2 3     CTG4A3
CTG Repeat Protein 4a2 3     

External Ids:    HGNC: 119681   Entrez Gene: 106952   Ensembl: ENSG000001371617   OMIM: 6107745   UniProtKB: Q9BT093   

Export aliases for CNPY3 gene to outside databases

Previous GC identifers: GC06P043004 GC06P042897 GC06P042614


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNPY3 Gene:
PRAT4A is associated with the immature form of TLR4 (MIM 603030) and regulates its cell surface expression
(Wakabayashi et al., 2006 (PubMed 16849487)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CNPY3 Gene:
CNPY3 (canopy FGF signaling regulator 3) is a protein-coding gene. Diseases associated with CNPY3 include swayback. GO annotations related to this gene include receptor binding. An important paralog of this gene is CNPY4.

UniProtKB/Swiss-Prot: CNPY3_HUMAN, Q9BT09
Function: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that
of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and
adaptive immune responses (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNPY3 gene promoter:
         GR   AML1a   RelA   AP-4   NF-kappaB   LCR-F1   GATA-2   GR-alpha   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNPY3 promoter sequence
   Search Chromatin IP Primers for CNPY3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNPY3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

CNPY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNPY3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P042901:  view genomic region     (about GC identifiers)

Start:
42,896,860 bp from pter      End:
42,907,025 bp from pter
Size:
10,166 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CNPY3_HUMAN, Q9BT09 (See protein sequence)
Recommended Name: Protein canopy homolog 3 precursor  
Size: 278 amino acids; 30748 Da
Subunit: Interacts with HSP90B1; this interaction is disrupted in the presence of ATP. Interacts with TLR1, TLR2,
TLR4 and TLR9 (By similarity). Strongest interaction with TLR4 (By similarity)
Sequence caution: Sequence=AAB91442.1; Type=Frameshift; Positions=109; Sequence=AAF28907.1; Type=Frameshift;
Positions=252;
Secondary accessions: O15412 Q0P6I2 Q8NF54 Q8WTU8 Q9P0F2
Alternative splicing: 2 isoforms:  Q9BT09-1   Q9BT09-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CNPY3: NX_Q9BT09

Explore proteomics data for CNPY3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn153, Thr271
  • Modification sites at PhosphoSitePlus

  • See CNPY3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006577.2  
    ENSEMBL proteins: 
     ENSP00000361926   ENSP00000377698  
    Reactome Protein details: Q9BT09

    CNPY3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TNRC: Trinucleotide (CAG) repeat containing

    1 InterPro protein domain:
     IPR021852 DUF3456

    Graphical View of Domain Structure for InterPro Entry Q9BT09

    ProtoNet protein and cluster: Q9BT09

    UniProtKB/Swiss-Prot: CNPY3_HUMAN, Q9BT09
    Similarity: Belongs to the canopy family
    Similarity: Contains 1 saposin B-type domain


    CNPY3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNPY3_HUMAN, Q9BT09
    Function: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that
    of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and
    adaptive immune responses (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
         
    CNPY3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CNPY3:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cnpy3):
     growth/size/body  hematopoietic system  immune system  mortality/aging 

    CNPY3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cnpy3tm1Kmiy for CNPY3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNPY3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNPY3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNPY3

    miRNA
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    miRTarBase miRNAs that target CNPY3:
    hsa-mir-16-5p (MIRT031881), hsa-mir-346 (MIRT004231), hsa-mir-26b-5p (MIRT029859)

    Block miRNA regulation of human, mouse, rat CNPY3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CNPY3:
    hsa-miR-1910 hsa-miR-1289
    SwitchGear 3'UTR luciferase reporter plasmidCNPY3 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CNPY3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNPY3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNPY3_HUMAN, Q9BT09: Endoplasmic reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    extracellular3
    endosome2
    lysosome2
    vacuole2
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen TAS--

    CNPY3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNPY3 About    
    See pathways by source

    SuperPathContained pathways About
    1Trafficking and processing of endosomal TLR
    Trafficking and processing of endosomal TLR

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CNPY3
        Trafficking and processing of endosomal TLR



    CNPY3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNPY3
    Interactions:

        Search GeneGlobe Interaction Network for CNPY3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for CNPY3 (Q9BT093 ENSP000003619264) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSP90B1P146253, ENSP000002997674I2D: score=1 STRING: ENSP00000299767
    CREB3O438893I2D: score=1 
    TLR4O002063I2D: score=1 
    TLR3ENSP000002967954STRING: ENSP00000296795
    TLR7ENSP000003700344STRING: ENSP00000370034
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0045087innate immune response TAS--

    CNPY3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNPY3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CNPY3 gene (2 alternative transcripts): 
    NM_183010.1  NM_006586.3  

    Unigene Cluster for CNPY3:

    Canopy 3 homolog (zebrafish)
    Hs.414099  [show with all ESTs]
    Unigene Representative Sequence: AK124196
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372836(uc003osy.2 uc003ota.4 uc003otb.4) ENST00000394142

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CNPY3:
    hsa-miR-1910 hsa-miR-1289
    SwitchGear 3'UTR luciferase reporter plasmidCNPY3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CNPY3
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    Primer
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    OriGene qPCR primer pairs and template standards for CNPY3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNPY3
      QuantiTect SYBR Green Assays in human, mouse, rat CNPY3
      QuantiFast Probe-based Assays in human, mouse, rat CNPY3

    Additional mRNA sequence: 

    AF161347.1 AK124196.1 AY358960.1 BC004423.1 BC008898.2 BC008961.2 BC011767.2 BC022093.2 
    U80744.1 

    20 DOTS entries:

    DT.97805543  DT.75116165  DT.100829441  DT.87016750  DT.408910  DT.92443190  DT.100030575  DT.121394127 
    DT.95164873  DT.100829444  DT.65285732  DT.97847702  DT.100829442  DT.100829452  DT.121394106  DT.121394110 
    DT.92443197  DT.95164885  DT.100829448  DT.100829449 

    Selected AceView cDNA sequences (see all 366):

    BM927858 CK429647 AI758572 BU162961 CR606170 BQ883867 BU859120 CR625170 
    BU838086 BM920245 BC032627 BQ646663 CR593913 AF101477 BC008133 AK124196 
    BU193119 BU625250 CR617058 AI878843 BU169100 BM713817 BM788127 BM046925 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNPY3 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -     -                                   -     -     -                                                                     
    SP2:        -     -     -     -     -                       -     -     -                                                                     
    SP3:        -     -     -                 -                 -     -     -                                                                     
    SP4:        -     -     -     -     -     -                 -     -     -                                                                     
    SP5:        -     -                                         -     -     -                                                                     


    ECgene alternative splicing isoforms for CNPY3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNPY3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAGCCCAC
    CNPY3 Expression
    About this image


    CNPY3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
    CNPY3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNPY3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.414099
        Custom PCR Arrays for CNPY3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNPY3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CNPY3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnpy31 , 5 canopy 3 homolog (zebrafish)1, 5 85.14(n)1
    86.96(a)1
      17 (22.90 cM)5
    720291  NM_028065.31  NP_082341.11 
     467357055 
    chicken
    (Gallus gallus)
    Aves LOC1008589901 protein canopy homolog 3-like 75.8(n)
    77.17(a)
      100858990  XM_003640927.2  XP_003640975.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNPY36
    canopy FGF signaling regulator 3
    67(a)
    1 ↔ 1
    2(144900206-144910116)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.181562 Xenopus laevis transcribed sequence with weak similarity more 75.77(n)    BQ384245.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.189162 Transcribed sequence with weak similarity to protein more 73.32(n)    BM037488.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG115776
    --
    44(a)
    1 → many
    3L(19087990-19089317)
    worm
    (Caenorhabditis elegans)
    Secernentea C11H1.71 C11H1.7 48.96(n)
    36.87(a)
      182526  NM_077988.3  NP_510389.1 


    ENSEMBL Gene Tree for CNPY3 (if available)
    TreeFam Gene Tree for CNPY3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNPY3 gene
    CNPY42  
    1 SIMAP similar gene for CNPY3 using alignment to 1 protein entry:     CNPY3_HUMAN:
    CNPY4

    CNPY3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNPY3 (see all 269)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860373931,2
    --42894928(+) TGGCTC/TATTTT 1 -- us2k10--------
    rs1159755421,2
    F--42895178(+) GTGCTT/ATGTTA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs69284851,2
    C,F,H--42895188(+) ACCAAC/TACAGT 1 -- us2k17Minor allele frequency- T:0.04NS EA NA 990
    rs1148638501,2
    F--42895358(+) AACTTT/CGGTCT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1909558261,2
    --42895512(+) TCACTC/GCAACC 1 -- us2k10--------
    rs97176211,2
    H--42895594(+) cacggC/Ttattt 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs343944881,2
    C--42895793(+) GATCTC/-CGGCT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1393872091,2
    C--42895853(+) CCCGAA/GTAGCT 1 -- us2k10--------
    rs1825883521,2
    --42895954(+) ACTCCC/TGACCT 1 -- us2k10--------
    rs2012905001,2
    C--42896185(+) CCTTT-/TTCTTCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNPY3 (42896860 - 42907025 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CNPY3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830651CNV Loss17160897

    Human Gene Mutation Database (HGMD): CNPY3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNPY3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610774    OMIM disorders: --

    1 disease for CNPY3:    
    About MalaCards
    swayback

    1 disease from the University of Copenhagen DISEASES database for CNPY3:
    Swayback

    CNPY3 for disorders           About GeneDecksing


    Export disorders for CNPY3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNPY3 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with CNPY3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)1, 2, 3 Margolis R.L.... Ross C.A. (Hum. Genet. 1997)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Cell surface trafficking of TLR1 is differentially regulated by the chaperones PRAT4A and PRAT4B. (PubMed id 22447933)1 Hart B.E. and Tapping R.I. (J. Biol. Chem. 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. (PubMed id 20865800)2 Liu B.... Li Z. (Nat. Commun. 2010)
    7. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    8. A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4. (PubMed id 16849487)1 Wakabayashi Y....Miyake K. (J. Immunol. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10695 HGNC: 11968 AceView: TNRC5andGNMT Ensembl:ENSG00000137161 euGenes: HUgn10695
    ECgene: CNPY3 H-InvDB: CNPY3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CNPY3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNPY3 gene:
    Search GeneIP for patents involving CNPY3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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