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Aliases for CNPY2 Gene

Aliases for CNPY2 Gene

  • Canopy FGF Signaling Regulator 2 2 3 5
  • Transmembrane Protein 4 2 3 4
  • MIR-Interacting Saposin-Like Protein 3 4
  • Putative Secreted Protein Zsig9 3 4
  • TMEM4 3 4
  • ZSIG9 3 4
  • MSAP 3 4
  • Canopy 2 Homolog (Zebrafish) 2
  • Canopy 2 Homolog 3
  • HP10390 3

External Ids for CNPY2 Gene

Previous HGNC Symbols for CNPY2 Gene

  • TMEM4

Previous GeneCards Identifiers for CNPY2 Gene

  • GC12M054991
  • GC12M056704
  • GC12M053742

Summaries for CNPY2 Gene

GeneCards Summary for CNPY2 Gene

CNPY2 (Canopy FGF Signaling Regulator 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000144785.

UniProtKB/Swiss-Prot for CNPY2 Gene

  • Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY2 Gene

Genomics for CNPY2 Gene

Regulatory Elements for CNPY2 Gene

Enhancers for CNPY2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CNPY2 on UCSC Golden Path with GeneCards custom track

Promoters for CNPY2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNPY2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNPY2 Gene

Chromosome:
12
Start:
56,309,842 bp from pter
End:
56,316,344 bp from pter
Size:
6,503 bases
Orientation:
Minus strand

Genomic View for CNPY2 Gene

Genes around CNPY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNPY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNPY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY2 Gene

Proteins for CNPY2 Gene

  • Protein details for CNPY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2B0-CNPY2_HUMAN
    Recommended name:
    Protein canopy homolog 2
    Protein Accession:
    Q9Y2B0
    Secondary Accessions:
    • B2R7B9
    • Q9UHE9

    Protein attributes for CNPY2 Gene

    Size:
    182 amino acids
    Molecular mass:
    20652 Da
    Quaternary structure:
    • Interacts with MYLIP/MIR.

    Alternative splice isoforms for CNPY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNPY2 Gene

Proteomics data for CNPY2 Gene at MOPED

Post-translational modifications for CNPY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNPY2 Gene

No data available for DME Specific Peptides for CNPY2 Gene

Domains & Families for CNPY2 Gene

Protein Domains for CNPY2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNPY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2B0

UniProtKB/Swiss-Prot:

CNPY2_HUMAN :
  • Contains 1 saposin B-type domain.
  • Belongs to the canopy family.
Domain:
  • Contains 1 saposin B-type domain.
Family:
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY2: view

No data available for Gene Families for CNPY2 Gene

Function for CNPY2 Gene

Molecular function for CNPY2 Gene

UniProtKB/Swiss-Prot Function:
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
genes like me logo Genes that share phenotypes with CNPY2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CNPY2 Gene

Localization for CNPY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPY2 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNPY2 Gene COMPARTMENTS Subcellular localization image for CNPY2 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10072769
genes like me logo Genes that share ontologies with CNPY2: view

Pathways & Interactions for CNPY2 Gene

SuperPathways for CNPY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process ISS 22378787
genes like me logo Genes that share ontologies with CNPY2: view

No data available for Pathways by source and SIGNOR curated interactions for CNPY2 Gene

Drugs & Compounds for CNPY2 Gene

No Compound Related Data Available

Transcripts for CNPY2 Gene

Unigene Clusters for CNPY2 Gene

Canopy 2 homolog (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY2 Gene

No ASD Table

Relevant External Links for CNPY2 Gene

GeneLoc Exon Structure for
CNPY2
ECgene alternative splicing isoforms for
CNPY2

Expression for CNPY2 Gene

mRNA expression in normal human tissues for CNPY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNPY2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8) and Nasal epithelium (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CNPY2 Gene



SOURCE GeneReport for Unigene cluster for CNPY2 Gene Hs.8752

mRNA Expression by UniProt/SwissProt for CNPY2 Gene

Q9Y2B0-CNPY2_HUMAN
Tissue specificity: Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.
genes like me logo Genes that share expression patterns with CNPY2: view

Protein tissue co-expression partners for CNPY2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CNPY2 Gene

Orthologs for CNPY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNPY2 35
  • 93.22 (n)
  • 98.9 (a)
CNPY2 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CNPY2 35
  • 95.05 (n)
  • 98.9 (a)
-- 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cnpy2 35
  • 91.57 (n)
  • 97.59 (a)
Cnpy2 16
Cnpy2 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CNPY2 35
  • 99.82 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Cnpy2 35
  • 91.77 (n)
  • 97.59 (a)
chicken
(Gallus gallus)
Aves CNPY2 35
  • 69.05 (n)
  • 69.29 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cnpy2 35
  • 70.55 (n)
  • 76.69 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19577 35
zebrafish
(Danio rerio)
Actinopterygii cnpy2 35
  • 69.98 (n)
  • 70.81 (a)
cnpy2 36
  • 64 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9940 35
fruit fly
(Drosophila melanogaster)
Insecta sel 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F01F1.15 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4160 36
  • 40 (a)
OneToMany
Species with no ortholog for CNPY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNPY2 Gene

ENSEMBL:
Gene Tree for CNPY2 (if available)
TreeFam:
Gene Tree for CNPY2 (if available)

Paralogs for CNPY2 Gene

Paralogs for CNPY2 Gene

(1) SIMAP similar genes for CNPY2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CNPY2: view

Variants for CNPY2 Gene

Sequence variations from dbSNP and Humsavar for CNPY2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7299351 -- 56,311,680(+) ctgag(C/T)agctg intron-variant
rs796476 -- 56,312,113(+) gacct(A/C)gtgat intron-variant
rs34026747 -- 56,309,938(+) ACCTC(A/G)TCTGT downstream-variant-500B
rs111259180 -- 56,313,924(+) AAGAC(-/AG)AGTTT intron-variant
rs111307037 -- 56,311,388(+) GTGAG(A/G)TGGGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CNPY2 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Variation tolerance for CNPY2 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CNPY2 Gene

Disorders for CNPY2 Gene

Relevant External Links for CNPY2

Genetic Association Database (GAD)
CNPY2
Human Genome Epidemiology (HuGE) Navigator
CNPY2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNPY2

No disorders were found for CNPY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNPY2 Gene

Publications for CNPY2 Gene

  1. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PMID: 10072769) Yokoyama-Kobayashi M. … Kato S. (Gene 1999) 2 3 4 67
  2. MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. (PMID: 15905959) Bornhauser B.C. … Lindholm D. (Cell. Mol. Life Sci. 2005) 2 3
  3. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. (PMID: 12826659) Bornhauser B.C. … Lindholm D. (J. Biol. Chem. 2003) 3 23
  4. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  5. A secreted protein (Canopy 2, CNPY2) enhances angiogenesis and promotes smooth muscle cell migration and proliferation. (PMID: 25589425) Guo J. … Li R.K. (Cardiovasc. Res. 2015) 3

Products for CNPY2 Gene

Sources for CNPY2 Gene

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