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Aliases for CNPY2 Gene

Aliases for CNPY2 Gene

  • Canopy FGF Signaling Regulator 2 2 3
  • Transmembrane Protein 4 2 3 4
  • TMEM4 3 4 6
  • MSAP 3 4 6
  • MIR-Interacting Saposin-Like Protein 3 4
  • Putative Secreted Protein Zsig9 3 4
  • ZSIG9 3 4
  • Canopy 2 Homolog (Zebrafish) 2
  • Protein Canopy Homolog 2 3
  • Canopy 2 Homolog 3
  • HP10390 3
  • CNPY4 6

External Ids for CNPY2 Gene

Previous HGNC Symbols for CNPY2 Gene

  • TMEM4

Previous GeneCards Identifiers for CNPY2 Gene

  • GC12M054991
  • GC12M056704
  • GC12M053742

Summaries for CNPY2 Gene

GeneCards Summary for CNPY2 Gene

CNPY2 (Canopy FGF Signaling Regulator 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000144785.

UniProtKB/Swiss-Prot for CNPY2 Gene

  • Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY2 Gene

Genomics for CNPY2 Gene

Regulatory Elements for CNPY2 Gene

Genomic Location for CNPY2 Gene

Start:
56,309,842 bp from pter
End:
56,316,344 bp from pter
Size:
6,503 bases
Orientation:
Minus strand

Genomic View for CNPY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNPY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY2 Gene

Proteins for CNPY2 Gene

  • Protein details for CNPY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2B0-CNPY2_HUMAN
    Recommended name:
    Protein canopy homolog 2
    Protein Accession:
    Q9Y2B0
    Secondary Accessions:
    • B2R7B9
    • Q9UHE9

    Protein attributes for CNPY2 Gene

    Size:
    182 amino acids
    Molecular mass:
    20652 Da
    Quaternary structure:
    • Interacts with MYLIP/MIR.

    Alternative splice isoforms for CNPY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNPY2 Gene

Proteomics data for CNPY2 Gene at MOPED

Post-translational modifications for CNPY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNPY2 Gene

No data available for DME Specific Peptides for CNPY2 Gene

Domains for CNPY2 Gene

Protein Domains for CNPY2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNPY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2B0

UniProtKB/Swiss-Prot:

CNPY2_HUMAN :
  • Q9Y2B0
Domain:
  • Contains 1 saposin B-type domain.
Family:
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY2: view

No data available for Gene Families for CNPY2 Gene

Function for CNPY2 Gene

Molecular function for CNPY2 Gene

UniProtKB/Swiss-Prot Function: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation

Gene Ontology (GO) - Molecular Function for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12826659
genes like me logo Genes that share ontologies with CNPY2: view

Phenotypes for CNPY2 Gene

GenomeRNAi human phenotypes for CNPY2:
genes like me logo Genes that share phenotypes with CNPY2: view

miRNA for CNPY2 Gene

miRTarBase miRNAs that target CNPY2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNPY2 Gene

Localization for CNPY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPY2 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNPY2 Gene COMPARTMENTS Subcellular localization image for CNPY2 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 3
extracellular 3

Gene Ontology (GO) - Cellular Components for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005887 integral component of plasma membrane TAS 10072769
genes like me logo Genes that share ontologies with CNPY2: view

Pathways for CNPY2 Gene

SuperPathways for CNPY2 Gene

No Data Available

Interacting Proteins for CNPY2 Gene

Gene Ontology (GO) - Biological Process for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression ISS 22378787
GO:0010988 regulation of low-density lipoprotein particle clearance ISS 22378787
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process ISS 22378787
genes like me logo Genes that share ontologies with CNPY2: view

No data available for Pathways by source for CNPY2 Gene

Transcripts for CNPY2 Gene

Unigene Clusters for CNPY2 Gene

Canopy 2 homolog (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY2 Gene

No ASD Table

Relevant External Links for CNPY2 Gene

GeneLoc Exon Structure for
CNPY2
ECgene alternative splicing isoforms for
CNPY2

Expression for CNPY2 Gene

mRNA expression in normal human tissues for CNPY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNPY2 Gene

SOURCE GeneReport for Unigene cluster for CNPY2 Gene Hs.8752

mRNA Expression by UniProt/SwissProt for CNPY2 Gene

Q9Y2B0-CNPY2_HUMAN
Tissue specificity: Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.
genes like me logo Genes that share expressions with CNPY2: view

No data available for mRNA differential expression in normal tissues for CNPY2 Gene

Orthologs for CNPY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNPY2 35
  • 99.82 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CNPY2 35
  • 93.22 (n)
  • 98.9 (a)
CNPY2 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 89 (a)
OneToMany
CNPY2 35
  • 95.05 (n)
  • 98.9 (a)
mouse
(Mus musculus)
Mammalia Cnpy2 35
  • 91.57 (n)
  • 97.59 (a)
Cnpy2 16
Cnpy2 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cnpy2 35
  • 91.77 (n)
  • 97.59 (a)
chicken
(Gallus gallus)
Aves CNPY2 35
  • 69.05 (n)
  • 69.29 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.19577 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cnpy2 35
  • 70.55 (n)
  • 76.69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9940 35
zebrafish
(Danio rerio)
Actinopterygii cnpy2 35
  • 69.98 (n)
  • 70.81 (a)
cnpy2 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sel 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F01F1.15 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4160 36
  • 40 (a)
OneToMany
Species with no ortholog for CNPY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNPY2 Gene

ENSEMBL:
Gene Tree for CNPY2 (if available)
TreeFam:
Gene Tree for CNPY2 (if available)

Paralogs for CNPY2 Gene

Paralogs for CNPY2 Gene

Selected SIMAP similar genes for CNPY2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CNPY2: view

Variants for CNPY2 Gene

Sequence variations from dbSNP and Humsavar for CNPY2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs35548844 -- 56,315,486(+) ATAGG(-/G)TGAGG intron-variant
rs35777114 -- 56,315,385(+) AAGGG(-/G)CTTCT intron-variant
rs144361173 -- 56,315,331(+) TCAAA(G/T)GCCTC intron-variant
rs150816038 -- 56,315,691(+) GCGTC(C/T)CCACC intron-variant
rs182802003 -- 56,315,352(+) TGGCT(C/G)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNPY2 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Relevant External Links for CNPY2 Gene

HapMap Linkage Disequilibrium report
CNPY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPY2 Gene

Disorders for CNPY2 Gene

Relevant External Links for CNPY2

Genetic Association Database (GAD)
CNPY2
Human Genome Epidemiology (HuGE) Navigator
CNPY2
genes like me logo Genes that share disorders with CNPY2: view

No data available for UniProtKB/Swiss-Prot for CNPY2 Gene

Publications for CNPY2 Gene

  1. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. (PMID: 12826659) Bornhauser B.C. … Lindholm D. (J. Biol. Chem. 2003) 3 4 23
  2. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PMID: 10072769) Yokoyama-Kobayashi M. … Kato S. (Gene 1999) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. (PMID: 15905959) Bornhauser B.C. … Lindholm D. (Cell. Mol. Life Sci. 2005) 2 3

Products for CNPY2 Gene

Sources for CNPY2 Gene

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