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Aliases for CNPY2 Gene

Aliases for CNPY2 Gene

  • Canopy FGF Signaling Regulator 2 2 3
  • Transmembrane Protein 4 2 3 4
  • TMEM4 3 4 6
  • MSAP 3 4 6
  • MIR-Interacting Saposin-Like Protein 3 4
  • Putative Secreted Protein Zsig9 3 4
  • ZSIG9 3 4
  • Canopy 2 Homolog (Zebrafish) 2
  • Protein Canopy Homolog 2 3
  • Canopy 2 Homolog 3
  • HP10390 3
  • CNPY4 6

External Ids for CNPY2 Gene

Previous Symbols for CNPY2 Gene

  • TMEM4

Summaries for CNPY2 Gene

GeneCards Summary for CNPY2 Gene

CNPY2 (Canopy FGF Signaling Regulator 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000144785.

UniProtKB/Swiss-Prot for CNPY2 Gene

  • Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY2 Gene

Genomics for CNPY2 Gene

Genomic Location for CNPY2 Gene

56,309,842 bp from pter
56,316,344 bp from pter
6,503 bases
Minus strand

Genomic View for CNPY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNPY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY2 Gene

Regulatory Elements for CNPY2 Gene

Proteins for CNPY2 Gene

  • Protein details for CNPY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein canopy homolog 2
    Protein Accession:
    Secondary Accessions:
    • B2R7B9
    • Q9UHE9

    Protein attributes for CNPY2 Gene

    182 amino acids
    Molecular mass:
    20652 Da
    Quaternary structure:
    • Interacts with MYLIP/MIR.

    Alternative splice isoforms for CNPY2 Gene


neXtProt entry for CNPY2 Gene

Proteomics data for CNPY2 Gene at MOPED

Post-translational modifications for CNPY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNPY2 Gene

No data available for DME Specific Peptides for CNPY2 Gene

Domains for CNPY2 Gene

Protein Domains for CNPY2 Gene



  • Contains 1 saposin B-type domain.:
    • Q9Y2B0
  • Belongs to the canopy family.:
    • Q9Y2B0
genes like me logo Genes that share domains with CNPY2: view

No data available for Gene Families for CNPY2 Gene

Function for CNPY2 Gene

Molecular function for CNPY2 Gene

UniProtKB/Swiss-Prot Function: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation

Gene Ontology (GO) - Molecular Function for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12826659
genes like me logo Genes that share ontologies with CNPY2: view

Phenotypes for CNPY2 Gene

GenomeRNAi human phenotypes for CNPY2:
genes like me logo Genes that share phenotypes with CNPY2: view

miRNA for CNPY2 Gene

miRTarBase miRNAs that target CNPY2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNPY2 Gene

Localization for CNPY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPY2 Gene

Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for CNPY2 Gene COMPARTMENTS Subcellular localization image for CNPY2 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 3
extracellular 3

Gene Ontology (GO) - Cellular Components for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005887 integral component of plasma membrane TAS 10072769
genes like me logo Genes that share ontologies with CNPY2: view

Pathways for CNPY2 Gene

SuperPathways for CNPY2 Gene

No Data Available

Interacting Proteins for CNPY2 Gene

Gene Ontology (GO) - Biological Process for CNPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression ISS 22378787
GO:0010988 regulation of low-density lipoprotein particle clearance ISS 22378787
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process ISS 22378787
genes like me logo Genes that share ontologies with CNPY2: view

No data available for Pathways by source for CNPY2 Gene

Transcripts for CNPY2 Gene

Unigene Clusters for CNPY2 Gene

Canopy 2 homolog (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY2 Gene

No ASD Table

Relevant External Links for CNPY2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNPY2 Gene

mRNA expression in normal human tissues for CNPY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNPY2 Gene

SOURCE GeneReport for Unigene cluster for CNPY2 Gene Hs.8752

mRNA Expression by UniProt/SwissProt for CNPY2 Gene

Tissue specificity: Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.
genes like me logo Genes that share expressions with CNPY2: view

Orthologs for CNPY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNPY2 36
  • 99.82 (n)
  • 100 (a)
(Bos Taurus)
Mammalia CNPY2 36
  • 93.22 (n)
  • 98.9 (a)
CNPY2 37
  • 99 (a)
(Canis familiaris)
Mammalia -- 37
  • 89 (a)
CNPY2 36
  • 95.05 (n)
  • 98.9 (a)
(Mus musculus)
Mammalia Cnpy2 36
  • 91.57 (n)
  • 97.59 (a)
Cnpy2 16
Cnpy2 37
  • 97 (a)
(Rattus norvegicus)
Mammalia Cnpy2 36
  • 91.77 (n)
  • 97.59 (a)
(Gallus gallus)
Aves CNPY2 36
  • 69.05 (n)
  • 69.29 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 72 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19577 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cnpy2 36
  • 70.55 (n)
  • 76.69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9940 36
(Danio rerio)
Actinopterygii cnpy2 36
  • 69.98 (n)
  • 70.81 (a)
cnpy2 37
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta sel 37
  • 25 (a)
(Caenorhabditis elegans)
Secernentea F01F1.15 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4160 37
  • 40 (a)
Species with no ortholog for CNPY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNPY2 Gene

Gene Tree for CNPY2 (if available)
Gene Tree for CNPY2 (if available)

Paralogs for CNPY2 Gene

Paralogs for CNPY2 Gene

Selected SIMAP similar genes for CNPY2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CNPY2: view

Variants for CNPY2 Gene

Sequence variations from dbSNP and Humsavar for CNPY2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs35548844 -- 56,315,486(+) ATAGG(-/G)TGAGG intron-variant
rs35777114 -- 56,315,385(+) AAGGG(-/G)CTTCT intron-variant
rs144361173 -- 56,315,331(+) TCAAA(G/T)GCCTC intron-variant
rs150816038 -- 56,315,691(+) GCGTC(C/T)CCACC intron-variant
rs182802003 -- 56,315,352(+) TGGCT(C/G)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNPY2 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Relevant External Links for CNPY2 Gene

HapMap Linkage Disequilibrium report

Disorders for CNPY2 Gene

Relevant External Links for CNPY2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CNPY2: view

No data available for UniProtKB/Swiss-Prot for CNPY2 Gene

Publications for CNPY2 Gene

  1. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. (PMID: 12826659) Bornhauser B.C. … Lindholm D. (J. Biol. Chem. 2003) 3 4 23
  2. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PMID: 10072769) Yokoyama-Kobayashi M. … Kato S. (Gene 1999) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. (PMID: 15905959) Bornhauser B.C. … Lindholm D. (Cell. Mol. Life Sci. 2005) 2 3

Products for CNPY2 Gene

Sources for CNPY2 Gene

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