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CNPY2 Gene

protein-coding   GIFtS: 50
GCID: GC12M056704

Canopy FGF Signaling Regulator 2

(Previous names: transmembrane protein 4, canopy 2 homolog (zebrafish))
(Previous symbol: TMEM4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Canopy FGF Signaling Regulator 21 2     MIR-Interacting Saposin-Like Protein2 3
TMEM41 2 3 5     Canopy 2 Homolog (Zebrafish)1
Transmembrane Protein 41 2 3     HP103902
MSAP2 3 5     Canopy 2 Homolog2
Putative Secreted Protein Zsig92 3     Protein Canopy Homolog 22
ZSIG92 3     CNPY45

External Ids:    HGNC: 135291   Entrez Gene: 103302   Ensembl: ENSG000002577277   OMIM: 6058615   UniProtKB: Q9Y2B03   

Export aliases for CNPY2 gene to outside databases

Previous GC identifers: GC12M054991 GC12M053742


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CNPY2 Gene:
CNPY2 (canopy FGF signaling regulator 2) is a protein-coding gene. An important paralog of this gene is ENSG00000144785.

UniProtKB/Swiss-Prot: CNPY2_HUMAN, Q9Y2B0
Function: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents
MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNPY2 gene promoter:
         GR   STAT1   CUTL1   GR-alpha   STAT5A   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNPY2 promoter sequence
   Search Chromatin IP Primers for CNPY2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNPY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q15

CNPY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNPY2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056704:  view genomic region     (about GC identifiers)

Start:
56,703,626 bp from pter      End:
56,710,128 bp from pter
Size:
6,503 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNPY2_HUMAN, Q9Y2B0 (See protein sequence)
Recommended Name: Protein canopy homolog 2 precursor  
Size: 182 amino acids; 20652 Da
Subunit: Interacts with MYLIP/MIR
Secondary accessions: B2R7B9 Q9UHE9
Alternative splicing: 2 isoforms:  Q9Y2B0-1   Q9Y2B0-2   

Explore the universe of human proteins at neXtProt for CNPY2: NX_Q9Y2B0

Explore proteomics data for CNPY2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CNPY2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177920.1  NP_055070.1  

    ENSEMBL proteins: 
     ENSP00000448333   ENSP00000449444   ENSP00000273308   ENSP00000448809   ENSP00000446784  

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    antibodies-online proteins for CNPY2 (10 products) 

     
    antibodies-online peptides for CNPY2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021852 DUF3456
     IPR008139 SaposinB

    Graphical View of Domain Structure for InterPro Entry Q9Y2B0

    ProtoNet protein and cluster: Q9Y2B0

    1 Blocks protein domain: IPB008139 Saposin B

    UniProtKB/Swiss-Prot: CNPY2_HUMAN, Q9Y2B0
    Similarity: Belongs to the canopy family
    Similarity: Contains 1 saposin B-type domain


    Find genes that share domains with CNPY2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNPY2_HUMAN, Q9Y2B0
    Function: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents
    MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12826659
         
    Find genes that share ontologies with CNPY2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CNPY2:
     Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CNPY2

    miRNA
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    miRTarBase miRNAs that target CNPY2:
    hsa-mir-30a-5p (MIRT005173)

    Block miRNA regulation of human, mouse, rat CNPY2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CNPY2:
    hsa-miR-3163 hsa-miR-548am hsa-miR-548d-3p hsa-miR-637 hsa-miR-548x
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNPY2_HUMAN, Q9Y2B0: Endoplasmic reticulum (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum3
    extracellular3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005887integral component of plasma membrane TAS10072769

    Find genes that share ontologies with CNPY2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNPY2
    Interactions:

        Search GeneGlobe Interaction Network for CNPY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for CNPY2 (Q9Y2B03 ENSP000002733084) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLXIPQ9HAP23, ENSP000003128344I2D: score=2 STRING: ENSP00000312834
    MYLIPQ8WY643, ENSP000003492984I2D: score=2 STRING: ENSP00000349298
    TNIKQ9UKE53, ENSP000003995114I2D: score=1 STRING: ENSP00000399511
    ATG5Q9H1Y03I2D: score=1 
    DDIT3P356383I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010629negative regulation of gene expression ISS--
    GO:0010988regulation of low-density lipoprotein particle clearance ISS--
    GO:0045716positive regulation of low-density lipoprotein particle receptor biosynthetic process ISS--

    Find genes that share ontologies with CNPY2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNPY2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNPY2 gene (2 alternative transcripts): 
    NM_001190991.1  NM_014255.5  

    Unigene Cluster for CNPY2:

    Canopy 2 homolog (zebrafish)
    Hs.8752  [show with all ESTs]
    Unigene Representative Sequence: NM_014255
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546466 ENST00000546937 ENST00000553191 ENST00000273308(uc001sku.2)
    ENST00000551475 ENST00000551286 ENST00000551720 ENST00000551276 ENST00000547570
    ENST00000548013(uc001skv.3) ENST00000553164 ENST00000546388
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate CNPY2:
    hsa-miR-3163 hsa-miR-548am hsa-miR-548d-3p hsa-miR-637 hsa-miR-548x
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      QuantiTect SYBR Green Assays in human, mouse, rat CNPY2
      QuantiFast Probe-based Assays in human, mouse, rat CNPY2

    Additional mRNA sequence: 

    AB015631.1 AF186113.1 AK312921.1 AL831869.1 AY032624.1 AY359102.1 BC001027.2 BC065015.1 

    Selected DOTS entries (see all 26):

    DT.454803  DT.75100158  DT.100792688  DT.102835386  DT.121119662  DT.92057331  DT.97766255  DT.316118 
    DT.75102814  DT.92442269  DT.100044358  DT.95191666  DT.121119964  DT.99950954  DT.100675481  DT.121119675 
    DT.316119  DT.91665523  DT.95191669  DT.121119623  DT.92442266  DT.95191667  DT.95278790  DT.100792690 

    Selected AceView cDNA sequences (see all 58):

    AW026269 BI760558 BF990365 BM552907 BM832828 BG025360 CD368274 BF995391 
    BF344334 BI763950 CA310087 AW028115 BM832888 AY032624 BU195582 AI306532 
    AI564881 AA314807 CA432204 AA878370 AA923492 BE394202 BC065015 AA632355 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNPY2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAGCTATG
    CNPY2 Expression
    About this image


    CNPY2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
    CNPY2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNPY2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8752

    UniProtKB/Swiss-Prot: CNPY2_HUMAN, Q9Y2B0
    Tissue specificity: Expressed in different tissues. Highest levels are detected in adult placenta, liver and
    pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CNPY2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnpy21 , 5 canopy 2 homolog (zebrafish)1, 5 91.57(n)1
    97.59(a)1
      10 (76.52 cM)5
    565301  NM_019953.11  NP_064337.11 
     1283224595 
    chicken
    (Gallus gallus)
    Aves CNPY21 canopy 2 homolog (zebrafish) 69.05(n)
    69.29(a)
      100858933  XM_003643957.2  XP_003644005.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    72(a)
    1 → many
    2(93681247-93695495)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195772 Xenopus laevis transcribed sequence with moderate similarity more 74.92(n)    BQ387527.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cnpy21 canopy 2 69.98(n)
    70.81(a)
      664684  NM_001039826.2  NP_001034915.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta sel6
    seele
    25(a)
    1 → many
    2R(5938367-5939682)
    worm
    (Caenorhabditis elegans)
    Secernentea F01F1.156
    Protein F01F1.15 (F01F1.15) mRNA, complete cds
    30(a)
    1 → many
    III(5868587-5869620) WBGene00017169


    ENSEMBL Gene Tree for CNPY2 (if available)
    TreeFam Gene Tree for CNPY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNPY2 gene
    ENSG000001447852  CNPY12  
    1 SIMAP similar gene for CNPY2 using alignment to 5 protein entries:     CNPY2_HUMAN (see all proteins):
    CNPY1

    Find genes that share paralogs with CNPY2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNPY2 (see all 111)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340267471,2
    C,F--56703722(+) ACCTCG/ATCTGT 1 -- ds50014Minor allele frequency- A:0.03NA 126
    rs1463520091,2
    --56704010(+) TGAGTA/GGGCAC 1 -- ds50010--------
    rs731310041,2
    C,F--56704049(+) GGAGTG/CGAATC 1 -- ds50011Minor allele frequency- C:0.06NA 120
    rs1927129411,2
    --56704130(+) TTCTCC/TTCCAT 1 -- ds50010--------
    rs107837801,2
    C,F,A,H--56704152(+) TCTATA/GTAACT 1 -- ds500124Minor allele frequency- G:0.17NS EA NA 2720
    rs1397160871,2
    --56704161(+) CTCCTC/TATCTT 1 -- ds50010--------
    rs1840471741,2
    --56704171(+) TCAAGC/TTTAAT 1 -- ds50010--------
    rs1444288331,2
    C,F--56704347(+) CTCATC/TATGCG 2 N D mis11Minor allele frequency- T:0.00NA 4550
    rs1998903061,2
    C--56704382(+) GATCTA/GCAAAT 1 -- int10--------
    rs1506361431,2
    C--56704425(+) TACTGA/GTATCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CNPY2 (56703626 - 56710128 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CNPY2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv482992CNV Complex15286789

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CNPY2
    DNA2.0 Custom Variant and Variant Library Synthesis for CNPY2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605861    OMIM disorders: --


    Find genes that share disorders with CNPY2           About GenesLikeMe

    Genetic Association Database (GAD): CNPY2
    Human Genome Epidemiology (HuGE) Navigator: CNPY2 (1 document)

    Export disorders for CNPY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNPY2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CNPY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PubMed id 10072769)1, 2, 3 Yokoyama-Kobayashi M.... Kato S. (Gene 1999)
    2. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. (PubMed id 12826659)1, 2, 9 Bornhauser B.C.... Lindholm D. (J. Biol. Chem. 2003)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. (PubMed id 15905959)1, 3 Bornhauser B.C. and Lindholm D. (Cell. Mol. Life Sci. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap). (PubMed id 22378787)1 Do H.T....Lindholm D. (J. Biol. Chem. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10330 HGNC: 13529 AceView: TMEM4 Ensembl:ENSG00000257727 euGenes: HUgn10330
    ECgene: CNPY2 H-InvDB: CNPY2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNPY2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CNPY2 gene:
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