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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNPY2 Gene

protein-coding   GIFtS: 51
GCID: GC12M056704

Canopy FGF Signaling Regulator 2

(Previous names: transmembrane protein 4, canopy 2 homolog (zebrafish))
(Previous symbol: TMEM4)
  Search for CNPY2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Canopy FGF Signaling Regulator 21 2     MIR-Interacting Saposin-Like Protein2 3
TMEM41 2 3 5     Canopy 2 Homolog (Zebrafish)1
Transmembrane Protein 41 2 3     HP103902
MSAP2 3 5     Canopy 2 Homolog2
Putative Secreted Protein Zsig92 3     Protein Canopy Homolog 22
ZSIG92 3     CNPY45

External Ids:    HGNC: 135291   Entrez Gene: 103302   Ensembl: ENSG000002577277   OMIM: 6058615   UniProtKB: Q9Y2B03   

Export aliases for CNPY2 gene to outside databases

Previous GC identifers: GC12M054991 GC12M053742


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CNPY2 Gene: 
CNPY2 (canopy FGF signaling regulator 2) is a protein-coding gene. GO annotations related to this gene include protein binding. An important paralog of this gene is ENSG00000144785.

UniProtKB/Swiss-Prot: CNPY2_HUMAN, Q9Y2B0
Function: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents
MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNPY2 gene promoter:
         GR   STAT1   CUTL1   GR-alpha   STAT5A   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNPY2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNPY2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNPY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q15

CNPY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNPY2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056704:  view genomic region     (about GC identifiers)

Start:
56,703,626 bp from pter      End:
56,710,128 bp from pter
Size:
6,503 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNPY2_HUMAN, Q9Y2B0 (See protein sequence)
Recommended Name: Protein canopy homolog 2 precursor  
Size: 182 amino acids; 20652 Da
Subunit: Interacts with MYLIP/MIR
Subcellular location: Endoplasmic reticulum (Potential)
Secondary accessions: B2R7B9 Q9UHE9
Alternative splicing: 2 isoforms:  Q9Y2B0-1   Q9Y2B0-2   

Explore the universe of human proteins at neXtProt for CNPY2: NX_Q9Y2B0

Explore proteomics data for CNPY2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2B0

  • CNPY2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNPY2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001177920.1  NP_055070.1  

    ENSEMBL proteins: 
     ENSP00000448333   ENSP00000449444   ENSP00000273308   ENSP00000448809   ENSP00000446784  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005887integral to plasma membrane TAS10072769

    CNPY2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR021852 DUF3456
     IPR008139 SaposinB

    Graphical View of Domain Structure for InterPro Entry Q9Y2B0

    ProtoNet protein and cluster: Q9Y2B0

    1 Blocks protein domain: IPB008139 Saposin B

    UniProtKB/Swiss-Prot: CNPY2_HUMAN, Q9Y2B0
    Similarity: Belongs to the canopy family
    Similarity: Contains 1 saposin B-type domain


    CNPY2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNPY2_HUMAN, Q9Y2B0
    Function: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents
    MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12826659
         
    CNPY2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CNPY2:
     Increased HPV18 LCR reporter a 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNPY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/11 Interacting proteins for CNPY2 (Q9Y2B03 ENSP000002733084) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLXIPQ9HAP23, ENSP000003128344I2D: score=2 STRING: ENSP00000312834
    MYLIPQ8WY643, ENSP000003492984I2D: score=2 STRING: ENSP00000349298
    TNIKQ9UKE53, ENSP000003995114I2D: score=1 STRING: ENSP00000399511
    ATG5Q9H1Y03I2D: score=1 
    DDIT3P356383I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010629negative regulation of gene expression ISS--
    GO:0010988regulation of low-density lipoprotein particle clearance ISS--
    GO:0045716positive regulation of low-density lipoprotein particle receptor biosynthetic process ISS--

    CNPY2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNPY2

    Search CenterWatch for drugs/clinical trials and news about CNPY2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNPY2 gene (2 alternative transcripts): 
    NM_001190991.1  NM_014255.5  

    Unigene Cluster for CNPY2:

    Canopy 2 homolog (zebrafish)
    Hs.8752  [show with all ESTs]
    Unigene Representative Sequence: NM_014255
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546466 ENST00000546937 ENST00000553191 ENST00000273308(uc001sku.2)
    ENST00000551475 ENST00000551286 ENST00000551720 ENST00000551276 ENST00000547570
    ENST00000548013(uc001skv.3) ENST00000553164 ENST00000546388
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    hsa-miR-3163 hsa-miR-548am hsa-miR-548d-3p hsa-miR-637 hsa-miR-548x
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    Additional mRNA sequence: 

    AB015631.1 AF186113.1 AK312921.1 AL831869.1 AY032624.1 AY359102.1 BC001027.2 BC065015.1 

    24/26 DOTS entries (see all 26):

    DT.454803  DT.75100158  DT.100792688  DT.102835386  DT.121119662  DT.92057331  DT.97766255  DT.316118 
    DT.75102814  DT.92442269  DT.100044358  DT.95191666  DT.121119964  DT.99950954  DT.100675481  DT.121119675 
    DT.316119  DT.91665523  DT.95191669  DT.121119623  DT.92442266  DT.95191667  DT.95278790  DT.100792690 

    24/58 AceView cDNA sequences (see all 58):

    AI128534 BX280063 BM832828 CD368274 BF344334 AY032624 CR596106 AI564881 
    BU542456 BG002014 BE551426 AW028115 BF980928 BM832888 CD675876 AI306532 
    AI801716 AI867671 BG248455 BC065015 AA314807 CR603286 BQ695412 AA632355 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNPY2 expression in normal human tissues (normalized intensities)      CNPY2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAGCTATG
    CNPY2 Expression
    About this image


    CNPY2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle

    See CNPY2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNPY2

    SOURCE GeneReport for Unigene cluster: Hs.8752

    UniProtKB/Swiss-Prot: CNPY2_HUMAN, Q9Y2B0
    Tissue specificity: Expressed in different tissues. Highest levels are detected in adult placenta, liver and
    pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CNPY2 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnpy21 , 5 canopy 2 homolog (zebrafish)1, 5 91.58(n)1
    97.25(a)1
      10 (76.52 cM)5
    565301  NM_019953.11  NP_064337.11 
     1283224595 
    chicken
    (Gallus gallus)
    Aves LOC1008589331 protein canopy homolog 2-like 72.62(n)
    75(a)
      100858933  XM_003643957.1  XP_003644005.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    72(a)
    1 → many
    2(93681247-93695495)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195772 Xenopus laevis transcribed sequence with moderate similarity more 74.92(n)    BQ387527.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cnpy21 canopy 2 67.44(n)
    68.21(a)
      664684  NM_001039826.2  NP_001034915.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta sel6
    seele
    27(a)
    1 → many
    2R(5938367-5939682)
    worm
    (Caenorhabditis elegans)
    Secernentea F01F1.156
    Protein F01F1.15
    30(a)
    1 → many
    III(5868587-5869620)


    ENSEMBL Gene Tree for CNPY2 (if available)
    TreeFam Gene Tree for CNPY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNPY2 gene
    ENSG000001447852  CNPY12  
    1 SIMAP similar gene for CNPY2 using alignment to 5 protein entries:     CNPY2_HUMAN (see all proteins):
    CNPY1

    CNPY2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/111 SNPs in CNPY2 are shown (see all 111)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340267471,2
    C,F--56703722(+) ACCTCG/ATCTGT 1 -- ds50014Minor allele frequency- A:0.03NA 126
    rs1463520091,2
    --56704010(+) TGAGTA/GGGCAC 1 -- ds50010--------
    rs731310041,2
    C,F--56704049(+) GGAGTG/CGAATC 1 -- ds50011Minor allele frequency- C:0.06NA 120
    rs1927129411,2
    --56704130(+) TTCTCC/TTCCAT 1 -- ds50010--------
    rs107837801,2
    C,F,A,H--56704152(+) TCTATA/GTAACT 1 -- ds500124Minor allele frequency- G:0.17NS EA NA 2720
    rs1397160871,2
    --56704161(+) CTCCTC/TATCTT 1 -- ds50010--------
    rs1840471741,2
    --56704171(+) TCAAGC/TTTAAT 1 -- ds50010--------
    rs1444288331,2
    C,F--56704347(+) CTCATC/TATGCG 2 N D mis11Minor allele frequency- T:0.00NA 4550
    rs1998903061,2
    C--56704382(+) GATCTA/GCAAAT 1 -- int10--------
    rs1506361431,2
    C--56704425(+) TACTGA/GTATCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CNPY2 (56703626 - 56710128 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CNPY2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv482992CNV Complex15286789

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CNPY2 for disorders           About MalaCards
    OMIM gene information: 605861    OMIM disorders: --


    CNPY2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CNPY2
    Human Genome Epidemiology (HuGE) Navigator: CNPY2 (1 document)

    Export disorders for CNPY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNPY2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CNPY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PubMed id 10072769)1, 2, 3 Yokoyama-Kobayashi M.... Kato S. (1999)
    2. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. (PubMed id 12826659)1, 2, 9 Bornhauser B.C.... Lindholm D. (2003)
    3. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    4. MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. (PubMed id 15905959)1, 3 Bornhauser B.C. and Lindholm D. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Fibroblast growth factor-21 (FGF21) regulates low-dens ity lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Myli p/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap). (PubMed id 22378787)1 Do H.T....Lindholm D. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10330 HGNC: 13529 AceView: TMEM4 Ensembl:ENSG00000257727 euGenes: HUgn10330
    ECgene: CNPY2 H-InvDB: CNPY2

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for CNPY2 Pharmacogenomics, SNPs, Pathways

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    Patent Information for CNPY2 gene:
    Search GeneIP for patents involving CNPY2

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