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Aliases for CNPY1 Gene

Aliases for CNPY1 Gene

  • Canopy FGF Signaling Regulator 1 2 3 5
  • Canopy 1 Homolog (Zebrafish) 2

External Ids for CNPY1 Gene

Previous GeneCards Identifiers for CNPY1 Gene

  • GC07M154649
  • GC07M154976
  • GC07M155266
  • GC07M149023

Summaries for CNPY1 Gene

Entrez Gene Summary for CNPY1 Gene

  • Cnpy1 is expressed in the midbrain-hindbrain (MHB) boundary in zebrafish, binds FGFR1 (MIM 136350), and plays a role in FGF signaling (Hirate and Okamoto, 2006 [PubMed 16488878]).[supplied by OMIM, Dec 2008]

GeneCards Summary for CNPY1 Gene

CNPY1 (Canopy FGF Signaling Regulator 1) is a Protein Coding gene. An important paralog of this gene is CNPY2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY1 Gene

Genomics for CNPY1 Gene

Regulatory Elements for CNPY1 Gene

Enhancers for CNPY1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G155471 1.4 VISTA ENCODE 11.2 +83.2 83217 1.8 HDGF ZSCAN4 GLI4 GLIS2 EGR1 KDM4B EGR2 SMARCA5 SP1 ZSCAN16 ENSG00000227365 CNPY1 BLACE EN2
GH07G155767 0.9 ENCODE dbSUPER 10.8 -214.2 -214185 3.5 HDGF CTCF ZNF654 TRIM22 MAX MNT ZNF2 RAD21 ZNF512 SMC3 CNPY1 ENSG00000236544 EN2 RBM33 PIR49030 LOC100506302
GH07G155584 0.5 ENCODE 11.2 -29.5 -29451 0.2 RAD51 RNF2 SUZ12 CBX2 EZH2 CNPY1 PIR45075
GH07G155484 0.8 FANTOM5 1.4 +71.4 71382 0.1 TAF1 MAX RAD21 YY1 ZFHX2 ZNF316 EGR1 HNF4G EZH2 SMAD5 ENSG00000236544 EN2 ENSG00000227365 PAXIP1 CNPY1
GH07G155467 0.7 FANTOM5 1.6 +87.4 87414 0.2 SP3 SUZ12 CHD1 CBX2 SP2 ZBTB8A EBF1 GLIS2 ZNF341 GLIS1 CNPY1 EN2 ENSG00000227365
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNPY1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNPY1 Gene

Chromosome:
7
Start:
155,474,206 bp from pter
End:
155,555,450 bp from pter
Size:
81,245 bases
Orientation:
Minus strand

Genomic View for CNPY1 Gene

Genes around CNPY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNPY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNPY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY1 Gene

Proteins for CNPY1 Gene

  • Protein details for CNPY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3B7I2-CNPY1_HUMAN
    Recommended name:
    Protein canopy homolog 1
    Protein Accession:
    Q3B7I2
    Secondary Accessions:
    • A6NGX3

    Protein attributes for CNPY1 Gene

    Size:
    92 amino acids
    Molecular mass:
    10960 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CNPY1 Gene

Post-translational modifications for CNPY1 Gene

No Post-translational modifications

Other Protein References for CNPY1 Gene

No data available for DME Specific Peptides for CNPY1 Gene

Domains & Families for CNPY1 Gene

Protein Domains for CNPY1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNPY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3B7I2

UniProtKB/Swiss-Prot:

CNPY1_HUMAN :
  • Belongs to the canopy family.
Family:
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY1: view

No data available for Gene Families for CNPY1 Gene

Function for CNPY1 Gene

Phenotypes for CNPY1 Gene

MGI mutant phenotypes for CNPY1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CNPY1: view

Animal Models for CNPY1 Gene

MGI Knock Outs for CNPY1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CNPY1 Gene

Localization for CNPY1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNPY1 gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CNPY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with CNPY1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CNPY1 Gene

Pathways & Interactions for CNPY1 Gene

SuperPathways for CNPY1 Gene

No Data Available

Interacting Proteins for CNPY1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000317439%0d%0a9606.ENSP00000225927%0d%0a9606.ENSP00000384144%0d%0a9606.ENSP00000283916%0d%0a
Selected Interacting proteins: ENSP00000317439 for CNPY1 Gene via STRING

Gene Ontology (GO) - Biological Process for CNPY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007167 enzyme linked receptor protein signaling pathway IBA --
GO:0009888 tissue development IBA --
genes like me logo Genes that share ontologies with CNPY1: view

No data available for Pathways by source and SIGNOR curated interactions for CNPY1 Gene

Drugs & Compounds for CNPY1 Gene

No Compound Related Data Available

Transcripts for CNPY1 Gene

mRNA/cDNA for CNPY1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNPY1 Gene

Canopy 1 homolog (zebrafish):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY1 Gene

No ASD Table

Relevant External Links for CNPY1 Gene

GeneLoc Exon Structure for
CNPY1
ECgene alternative splicing isoforms for
CNPY1

Expression for CNPY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNPY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNPY1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x24.3) and Brain - Cerebellum (x23.5).

Protein differential expression in normal tissues from HIPED for CNPY1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNPY1 Gene



Protein tissue co-expression partners for CNPY1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNPY1 Gene:

CNPY1

SOURCE GeneReport for Unigene cluster for CNPY1 Gene:

Hs.146751
genes like me logo Genes that share expression patterns with CNPY1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNPY1 Gene

Orthologs for CNPY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNPY1 34 35
  • 98.91 (n)
dog
(Canis familiaris)
Mammalia CNPY1 34 35
  • 89.13 (n)
cow
(Bos Taurus)
Mammalia CNPY1 34 35
  • 86.96 (n)
mouse
(Mus musculus)
Mammalia Cnpy1 34 16 35
  • 82.3 (n)
rat
(Rattus norvegicus)
Mammalia Cnpy1 34
  • 81.32 (n)
oppossum
(Monodelphis domestica)
Mammalia CNPY1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNPY1 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNPY1 35
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cnpy1 35
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sel 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F01F1.15 35
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4160 35
  • 16 (a)
OneToMany
Species where no ortholog for CNPY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CNPY1 Gene

ENSEMBL:
Gene Tree for CNPY1 (if available)
TreeFam:
Gene Tree for CNPY1 (if available)

Paralogs for CNPY1 Gene

Paralogs for CNPY1 Gene

(1) SIMAP similar genes for CNPY1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNPY1: view

Variants for CNPY1 Gene

Sequence variations from dbSNP and Humsavar for CNPY1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000039913 -- 155,511,721(+) TAGCT(A/C)GGAGA intron-variant
rs1000071078 -- 155,512,034(+) GGCCA(A/G)TAAGG intron-variant
rs1000102610 -- 155,516,259(+) AAGAG(C/G/T)TCTGA intron-variant
rs1000267620 -- 155,505,644(+) GTGGA(C/T)CTGCG intron-variant
rs1000313885 -- 155,526,089(+) ATGCA(A/G)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNPY1 Gene

Variant ID Type Subtype PubMed ID
nsv6017 CNV insertion 18451855
nsv824408 CNV gain 20364138
nsv831196 CNV gain 17160897

Variation tolerance for CNPY1 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNPY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNPY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPY1 Gene

Disorders for CNPY1 Gene

Relevant External Links for CNPY1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNPY1

No disorders were found for CNPY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNPY1 Gene

Publications for CNPY1 Gene

  1. Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish. (PMID: 16488878) Hirate Y. … Okamoto H. (Curr. Biol. 2006) 2 3 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64

Products for CNPY1 Gene

Sources for CNPY1 Gene

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