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Aliases for CNPY1 Gene

Aliases for CNPY1 Gene

  • Canopy FGF Signaling Regulator 1 2 3 5
  • Canopy 1 Homolog (Zebrafish) 2

External Ids for CNPY1 Gene

Previous GeneCards Identifiers for CNPY1 Gene

  • GC07M154649
  • GC07M154976
  • GC07M155266
  • GC07M149023

Summaries for CNPY1 Gene

Entrez Gene Summary for CNPY1 Gene

  • Cnpy1 is expressed in the midbrain-hindbrain (MHB) boundary in zebrafish, binds FGFR1 (MIM 136350), and plays a role in FGF signaling (Hirate and Okamoto, 2006 [PubMed 16488878]).[supplied by OMIM, Dec 2008]

GeneCards Summary for CNPY1 Gene

CNPY1 (Canopy FGF Signaling Regulator 1) is a Protein Coding gene. An important paralog of this gene is ENSG00000144785.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPY1 Gene

Genomics for CNPY1 Gene

Regulatory Elements for CNPY1 Gene

Genomic Location for CNPY1 Gene

Chromosome:
7
Start:
155,474,206 bp from pter
End:
155,533,862 bp from pter
Size:
59,657 bases
Orientation:
Minus strand

Genomic View for CNPY1 Gene

Genes around CNPY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNPY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNPY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPY1 Gene

Proteins for CNPY1 Gene

  • Protein details for CNPY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3B7I2-CNPY1_HUMAN
    Recommended name:
    Protein canopy homolog 1
    Protein Accession:
    Q3B7I2
    Secondary Accessions:
    • A6NGX3

    Protein attributes for CNPY1 Gene

    Size:
    92 amino acids
    Molecular mass:
    10960 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CNPY1 Gene

Proteomics data for CNPY1 Gene at MOPED

Post-translational modifications for CNPY1 Gene

No Post-translational modifications

Other Protein References for CNPY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNPY1 Gene

Domains & Families for CNPY1 Gene

Protein Domains for CNPY1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CNPY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3B7I2

UniProtKB/Swiss-Prot:

CNPY1_HUMAN :
  • Belongs to the canopy family.
Family:
  • Belongs to the canopy family.
genes like me logo Genes that share domains with CNPY1: view

No data available for Gene Families for CNPY1 Gene

Function for CNPY1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CNPY1 Gene

Localization for CNPY1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNPY1 Gene COMPARTMENTS Subcellular localization image for CNPY1 gene
Compartment Confidence
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CNPY1 Gene

Pathways & Interactions for CNPY1 Gene

SuperPathways for CNPY1 Gene

No Data Available

Interacting Proteins for CNPY1 Gene

Gene Ontology (GO) - Biological Process for CNPY1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CNPY1 Gene

Drugs & Compounds for CNPY1 Gene

No Compound Related Data Available

Transcripts for CNPY1 Gene

mRNA/cDNA for CNPY1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNPY1 Gene

Canopy 1 homolog (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNPY1 Gene

No ASD Table

Relevant External Links for CNPY1 Gene

GeneLoc Exon Structure for
CNPY1
ECgene alternative splicing isoforms for
CNPY1

Expression for CNPY1 Gene

mRNA expression in normal human tissues for CNPY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNPY1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x24.3) and Brain - Cerebellum (x23.5).

Protein differential expression in normal tissues from HIPED for CNPY1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CNPY1 Gene



SOURCE GeneReport for Unigene cluster for CNPY1 Gene Hs.146751

genes like me logo Genes that share expression patterns with CNPY1: view

Protein tissue co-expression partners for CNPY1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CNPY1 Gene

Orthologs for CNPY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPY1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNPY1 35
  • 86.96 (n)
  • 84.78 (a)
CNPY1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNPY1 35
  • 89.13 (n)
  • 88.04 (a)
CNPY1 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnpy1 35
  • 82.3 (n)
  • 72.84 (a)
Cnpy1 16
Cnpy1 36
  • 34 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNPY1 35
  • 98.91 (n)
  • 97.83 (a)
CNPY1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnpy1 35
  • 81.32 (n)
  • 74.73 (a)
oppossum
(Monodelphis domestica)
Mammalia CNPY1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNPY1 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNPY1 36
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cnpy1 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sel 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F01F1.15 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4160 36
  • 16 (a)
OneToMany
Species with no ortholog for CNPY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CNPY1 Gene

ENSEMBL:
Gene Tree for CNPY1 (if available)
TreeFam:
Gene Tree for CNPY1 (if available)

Paralogs for CNPY1 Gene

Paralogs for CNPY1 Gene

(1) SIMAP similar genes for CNPY1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNPY1: view

Variants for CNPY1 Gene

Sequence variations from dbSNP and Humsavar for CNPY1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1362907 -- 155,518,774(+) GTGGG(A/T)GAGTG intron-variant
rs1364519 -- 155,513,599(+) CATAT(A/G)TGCTT intron-variant
rs1364520 -- 155,508,381(+) TCAAG(C/T)CTTAG intron-variant
rs1559547 -- 155,513,442(+) TTTCA(C/G)TACAA intron-variant
rs1559548 -- 155,513,682(+) TTTTC(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNPY1 Gene

Variant ID Type Subtype PubMed ID
nsv824408 CNV Gain 20364138
nsv831196 CNV Gain 17160897
nsv6017 CNV Insertion 18451855
nsv889559 CNV Loss 21882294

Variation tolerance for CNPY1 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNPY1 Gene

HapMap Linkage Disequilibrium report
CNPY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPY1 Gene

Disorders for CNPY1 Gene

Relevant External Links for CNPY1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNPY1

No disorders were found for CNPY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNPY1 Gene

Publications for CNPY1 Gene

  1. Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish. (PMID: 16488878) Hirate Y. … Okamoto H. (Curr. Biol. 2006) 2 3 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CNPY1 Gene

Sources for CNPY1 Gene

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