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Aliases for CNPPD1 Gene

Aliases for CNPPD1 Gene

  • Cyclin Pas1/PHO80 Domain Containing 1 2 3 5
  • Cyclin Pas1/PHO80 Domain-Containing Protein 1 3 4
  • C2orf24 3 4
  • Chromosome 2 Open Reading Frame 24 2
  • Protein CNPPD1 3
  • CGI-57 3

External Ids for CNPPD1 Gene

Previous HGNC Symbols for CNPPD1 Gene

  • C2orf24

Previous GeneCards Identifiers for CNPPD1 Gene

  • GC02M220037

Summaries for CNPPD1 Gene

GeneCards Summary for CNPPD1 Gene

CNPPD1 (Cyclin Pas1/PHO80 Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding.

Additional gene information for CNPPD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNPPD1 Gene

Genomics for CNPPD1 Gene

Regulatory Elements for CNPPD1 Gene

Enhancers for CNPPD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H218566 1.8 FANTOM5 ENCODE dbSUPER 13.8 +608.8 608847 4.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B AAMP CNOT9 USP37 PLCD4 BCS1L NHEJ1 CNPPD1 SLC23A3 ZNF142 RNF25
GH02H219244 1.4 ENCODE dbSUPER 11.5 -72.0 -71954 11.2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GLB1L ZFAND2B DES LINC00608 LINC01803 ENSG00000234638 ANKZF1 ATG9A TUBA4A DNAJB2
GH02H219121 1.5 Ensembl ENCODE dbSUPER 10.3 +53.1 53096 7.2 FOXA2 ATF1 ARID4B YBX1 TCF12 FOS ATF7 RUNX3 SP5 REST SLC23A3 NHEJ1 IHH MIR375 LOC100129175 FEV CRYBA2 LINC00608 CNPPD1 RETREG2
GH02H219110 1.2 ENCODE dbSUPER 10.1 +65.9 65883 3 ELF3 FOXA2 ATF1 MLX ARID4B THRB ZSCAN9 RAD21 RARA YY1 IHH LOC100129175 MIR375 FEV CRYBA2 LINC00608 PTPRN NHEJ1 CDK5R2 ENSG00000235024
GH02H219569 1.1 ENCODE 10.3 -393.4 -393368 4 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF416 FOS ZNF142 RNF25 NHEJ1 INHA SLC23A3 STK36 STK11IP GLB1L DNPEP BCS1L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNPPD1 on UCSC Golden Path with GeneCards custom track

Promoters for CNPPD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000130512 664 3001 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9

Genomic Locations for CNPPD1 Gene

Genomic Locations for CNPPD1 Gene
chr2:219,171,897-219,178,164
(GRCh38/hg38)
Size:
6,268 bases
Orientation:
Minus strand
chr2:220,036,619-220,042,828
(GRCh37/hg19)

Genomic View for CNPPD1 Gene

Genes around CNPPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNPPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNPPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNPPD1 Gene

Proteins for CNPPD1 Gene

  • Protein details for CNPPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV87-CNPD1_HUMAN
    Recommended name:
    Protein CNPPD1
    Protein Accession:
    Q9BV87
    Secondary Accessions:
    • B2RC77
    • O75548
    • Q9H4N0
    • Q9UQN0

    Protein attributes for CNPPD1 Gene

    Size:
    410 amino acids
    Molecular mass:
    45456 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CNPPD1 Gene

Post-translational modifications for CNPPD1 Gene

  • Ubiquitination at Lys341
  • Modification sites at PhosphoSitePlus

Other Protein References for CNPPD1 Gene

No data available for DME Specific Peptides for CNPPD1 Gene

Domains & Families for CNPPD1 Gene

Gene Families for CNPPD1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CNPPD1 Gene

Suggested Antigen Peptide Sequences for CNPPD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV87

UniProtKB/Swiss-Prot:

CNPD1_HUMAN :
  • Belongs to the CNPPD1 family.
Family:
  • Belongs to the CNPPD1 family.
genes like me logo Genes that share domains with CNPPD1: view

Function for CNPPD1 Gene

Phenotypes From GWAS Catalog for CNPPD1 Gene

Gene Ontology (GO) - Molecular Function for CNPPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CNPPD1: view

Phenotypes for CNPPD1 Gene

GenomeRNAi human phenotypes for CNPPD1:
genes like me logo Genes that share phenotypes with CNPPD1: view

Animal Model Products

miRNA for CNPPD1 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNPPD1 Gene

Localization for CNPPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNPPD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNPPD1 gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CNPPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNPPD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CNPPD1 Gene

Pathways & Interactions for CNPPD1 Gene

SuperPathways for CNPPD1 Gene

No Data Available

Interacting Proteins for CNPPD1 Gene

Gene Ontology (GO) - Biological Process for CNPPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with CNPPD1: view

No data available for Pathways by source and SIGNOR curated interactions for CNPPD1 Gene

Drugs & Compounds for CNPPD1 Gene

No Compound Related Data Available

Transcripts for CNPPD1 Gene

Unigene Clusters for CNPPD1 Gene

Cyclin Pas1/PHO80 domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNPPD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - - -
SP3:
SP4: -
SP5:
SP6: -
SP7: - - - - - -
SP8:

Relevant External Links for CNPPD1 Gene

GeneLoc Exon Structure for
CNPPD1
ECgene alternative splicing isoforms for
CNPPD1

Expression for CNPPD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNPPD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNPPD1 Gene:

CNPPD1

SOURCE GeneReport for Unigene cluster for CNPPD1 Gene:

Hs.4973

Evidence on tissue expression from TISSUES for CNPPD1 Gene

  • Kidney(4.4)
  • Intestine(4.3)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with CNPPD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNPPD1 Gene

Orthologs for CNPPD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNPPD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNPPD1 33 34
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia cfa-mir-1840 34
  • 91 (a)
OneToOne
CNPPD1 33
  • 90.08 (n)
cow
(Bos Taurus)
Mammalia C2H2ORF24 34
  • 90 (a)
OneToOne
CNPPD1 33
  • 89.43 (n)
mouse
(Mus musculus)
Mammalia Cnppd1 33 16 34
  • 86.04 (n)
rat
(Rattus norvegicus)
Mammalia Cnppd1 33
  • 85.34 (n)
oppossum
(Monodelphis domestica)
Mammalia CNPPD1 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNPPD1 33
  • 65.99 (n)
lizard
(Anolis carolinensis)
Reptilia CNPPD1 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnppd1 33
  • 57.78 (n)
MGC75999 33
zebrafish
(Danio rerio)
Actinopterygii cnppd1 34
  • 45 (a)
OneToOne
wufa05h07 33
fruit fly
(Drosophila melanogaster)
Insecta CG40191 34
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F09G2.2 34
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8044 34
  • 28 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.466 33
Species where no ortholog for CNPPD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNPPD1 Gene

ENSEMBL:
Gene Tree for CNPPD1 (if available)
TreeFam:
Gene Tree for CNPPD1 (if available)

Paralogs for CNPPD1 Gene

No data available for Paralogs for CNPPD1 Gene

Variants for CNPPD1 Gene

Sequence variations from dbSNP and Humsavar for CNPPD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000271328 -- 219,176,030(+) AGATA(C/T)ATGTG intron-variant
rs1001437508 -- 219,175,922(+) CACTG(C/T)TGTTC intron-variant
rs1001505823 -- 219,174,614(+) AAAAA(C/T)TGGTT intron-variant
rs1001870314 -- 219,176,176(+) ACAAT(C/T)CCATT intron-variant
rs1002005708 -- 219,172,500(+) CCAGC(A/G)AGGCA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CNPPD1 Gene

Variant ID Type Subtype PubMed ID
nsv508200 CNV deletion 20534489
nsv3170 CNV deletion 18451855
esv3893555 CNV loss 25118596

Variation tolerance for CNPPD1 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.51; 94.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNPPD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNPPD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNPPD1 Gene

Disorders for CNPPD1 Gene

Relevant External Links for CNPPD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNPPD1

No disorders were found for CNPPD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNPPD1 Gene

Publications for CNPPD1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4 60
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 60
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for CNPPD1 Gene

Sources for CNPPD1 Gene

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