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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNPPD1 Gene

protein-coding   GIFtS: 42
GCID: GC02M220037

Cyclin Pas1/PHO80 Domain Containing 1

(Previous name: chromosome 2 open reading frame 24)
(Previous symbol: C2orf24)
  Search for CNPPD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin Pas1/PHO80 Domain Containing 11 2
C2orf241 2
Cyclin Pas1/PHO80 Domain-Containing Protein 12 3
Chromosome 2 Open Reading Frame 241
CGI-572
Protein CNPPD12

External Ids:    HGNC: 252201   Entrez Gene: 270132   Ensembl: ENSG000001156497   UniProtKB: Q9BV873   

Export aliases for CNPPD1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CNPPD1 Gene: 
CNPPD1 (cyclin Pas1/PHO80 domain containing 1) is a protein-coding gene. GO annotations related to this gene include protein kinase binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CNPPD1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CNPPD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNPPD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q36

CNPPD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNPPD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M220037:  view genomic region     (about GC identifiers)

Start:
220,036,619 bp from pter      End:
220,042,828 bp from pter
Size:
6,210 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNPD1_HUMAN, Q9BV87 (See protein sequence)
Recommended Name: Protein CNPPD1  
Size: 410 amino acids; 45456 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B2RC77 O75548 Q9H4N0 Q9UQN0

Explore the universe of human proteins at neXtProt for CNPPD1: NX_Q9BV87

Explore proteomics data for CNPPD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BV87

  • CNPPD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNPPD1 Protein Expression
    REFSEQ proteins: NP_056495.3  
    ENSEMBL proteins: 
     ENSP00000353698   ENSP00000386277   ENSP00000410109   ENSP00000405997  

    Human Recombinant Protein Products for CNPPD1: 
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    Cloud-Clone Corp. Proteins for CNPPD1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    CNPPD1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for CNPPD1 
    Cloud-Clone Corp. CLIAs for CNPPD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013922 Cyclin_PHO80-like

    Graphical View of Domain Structure for InterPro Entry Q9BV87

    ProtoNet protein and cluster: Q9BV87

    1 Blocks protein domain: IPB013922 Cyclin-related 2

    UniProtKB/Swiss-Prot: CNPD1_HUMAN, Q9BV87
    Similarity: Belongs to the CNPPD1 family


    CNPPD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IEA--
         
    CNPPD1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNPPD1 
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    SwitchGear 3'UTR luciferase reporter plasmidCNPPD1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNPPD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CNPPD1 (ENSP000003536984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--

    CNPPD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNPPD1 (CNPD1)

    Search CenterWatch for drugs/clinical trials and news about CNPPD1 / CNPD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNPPD1 gene: 
    NM_015680.4  

    Unigene Cluster for CNPPD1:

    Cyclin Pas1/PHO80 domain containing 1
    Hs.4973  [show with all ESTs]
    Unigene Representative Sequence: NM_015680
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360507(uc002vju.4) ENST00000409789(uc002vjv.3) ENST00000453038
    ENST00000451647
    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CNPPD1 (see all 13):
    hsa-miR-548d-3p hsa-miR-1283 hsa-miR-520d-5p hsa-miR-499-3p hsa-miR-324-3p hsa-miR-7 hsa-miR-548g hsa-miR-3168
    SwitchGear 3'UTR luciferase reporter plasmidCNPPD1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: CNPPD1 (NM_015680)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNPPD1
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    Additional mRNA sequence: 

    AF070638.1 AF151815.1 AK075274.1 AK311656.1 AK314975.1 AY007160.1 BC001393.2 BC012821.2 
    CR457401.1 

    18 DOTS entries:

    DT.100753475  DT.452951  DT.100812030  DT.100812033  DT.95364465  DT.100812024  DT.75169640  DT.87015761 
    DT.97864285  DT.100657823  DT.95364466  DT.100029776  DT.95364453  DT.100812025  DT.100812031  DT.120935082 
    DT.95364450  DT.91970027 

    24/300 AceView cDNA sequences (see all 300):

    AI978809 AW338391 CR615171 AI370457 AI139305 AI167851 BE910081 BM924735 
    CR616024 AF070638 BQ890561 BM908152 BM905662 BQ009785 CR621433 AI189642 
    CA313272 AA412483 BG056186 BM769102 AI886067 BM508209 AW471363 AI978820 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CNPPD1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:              -     -     -     -     -                                                                     
    SP2:                    -     -     -     -                                                                     
    SP3:                                                                                                            
    SP4:                                                                                      -                     
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CNPPD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNPPD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTGTGTG
    CNPPD1 Expression
    About this image


    See CNPPD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNPPD1

    SOURCE GeneReport for Unigene cluster: Hs.4973
        SABiosciences Custom PCR Arrays for CNPPD1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNPPD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CNPPD1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnppd11 , 5 RIKEN cDNA 1810031K17 gene5
    cyclin Pas1/PHO80 domain containing 11
    86.04(n)1
    85.47(a)1
      1 (38.60 cM)5
    691711  NM_026977.21  NP_081253.11 
     751352155 
    chicken
    (Gallus gallus)
    Aves CNPPD11 cyclin Pas1/PHO80 domain containing 1 66.75(n)
    64.29(a)
      424204  NM_001039307.1  NP_001034396.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNPPD16
    Uncharacterized protein
    55(a)
    1 ↔ 1
    1(88194806-88210084)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC759992 hypothetical protein MGC75999 75.53(n)    BC061409.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa05h072 wufa05h07 73.95(n)   334868  BC044514.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG401916
    --
    23(a)
    1 ↔ 1
    2RHet(390776-392982)
    worm
    (Caenorhabditis elegans)
    Secernentea F09G2.26
    Protein F09G2.2
    20(a)
    1 ↔ 1
    V(7196916-7198438)


    ENSEMBL Gene Tree for CNPPD1 (if available)
    TreeFam Gene Tree for CNPPD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/143 SNPs in CNPPD1 are shown (see all 143)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0243004
    ----see VAR_0243002 L P mis40--------
    rs739935071,2
    C,F--220036819(+) CATTAG/AACTAA 1 -- ut313Minor allele frequency- A:0.11WA CSA 122
    rs1446872311,2
    --220036860(+) TGCCTC/TACCCA 1 -- ut310--------
    rs2004132211,2
    C--220036975(+) CTCCC-/CCTATA 1 -- ut310--------
    rs112361,2
    C,F,A,H--220037097(-) ATGCCG/ACCAGG 1 -- ut31 ese330Minor allele frequency- A:0.34MN EA NA NS WA CSA 4350
    rs1453388731,2
    --220037182(+) ATAAGC/TTCCCA 1 -- ut310--------
    rs2019580591,2
    C--220037299(+) CCTCAC/GAGCCC 1 -- ut311Minor allele frequency- G:0.00EU 1073
    rs1914431101,2
    --220037308(+) CCTACA/CTAGCC 2 * Y --0--------
    rs176551231,2,4
    C,F,H--220037444(+) ACCAGA/G/TGGCTG 3 H P L mis1 ese323NA NS EA WA EU 7612
    rs791395131,2
    C--220037456(+) ACAGCA/GCAGTG 2 A V mis10--------

    HapMap Linkage Disequilibrium report for CNPPD1 (220036619 - 220042828 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CNPPD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3170CNV Loss18451855
    nsv875869CNV Loss21882294
    nsv508200CNV Loss20534489
    nsv875868CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNPPD1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CNPPD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    3. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
    4. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27013 HGNC: 25220 AceView: C2orf24 Ensembl:ENSG00000115649 euGenes: HUgn27013
    ECgene: CNPPD1 H-InvDB: CNPPD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNPPD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNPPD1 gene:
    Search GeneIP for patents involving CNPPD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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