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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNP Gene

protein-coding   GIFtS: 56
GCID: GC17P040118

2',3'-cyclic nucleotide 3' phosphodiesterase
 Explore 32 diseases affiliated with
CNP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CNP    

Aliases
for CNP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
2',3'-Cyclic Nucleotide 3' Phosphodiesterase1 2
CNPase2 3
EC 3.1.4.373 8
CNP12 5
2', 3' Cyclic Nucleotide 3' Phosphohydrolase2
2',3'-Cyclic-Nucleotide 3'-Phosphodiesterase2

External Ids:    HGNC: 21581   Entrez Gene: 12672   Ensembl: ENSG000001737867   OMIM: 1238305   UniProtKB: P095433   

Export aliases for CNP gene to outside databases

Previous GC identifers: GC17P039672 GC17P042274 GC17P040027 GC17P040491 GC17P037372 GC17P035884


Summaries
for CNP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CN37_HUMAN, P09543
Function: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central
nervous system myelin (By similarity)

Gene Wiki entry for CNP (2',3'-Cyclic-nucleotide 3'-phosphodiesterase)


Genomic Views
for CNP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNP gene promoter:
         C/EBPbeta   Tal-1   p53   MyoD   LUN-1   HNF-4alpha2   HNF-4alpha1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNP promoter sequence
   Search SABiosciences Chromatin IP Primers for CNP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21

CNP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNP gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040118:  view genomic region     (about GC identifiers)

Start:
 40,118,759 bp from pter      End:
 40,129,754 bp from pter
Size:
 10,996 bases      Orientation:
 plus strand

Proteins
for CNP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CN37_HUMAN, P09543 (See protein sequence)
Recommended Name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase  
Size: 421 amino acids; 47579 Da
Subunit: Exists as monomers and homodimers (By similarity)
Subcellular location: Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white
matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV
1 PDB 3D structure from and Proteopedia for CNP:
1WOJ (3D)    
Alternative splicing: 2 isoforms:  P09543-1   P09543-2   

Explore the universe of human proteins at neXtProt for CNP: NX_P09543

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09543

    • 4/7 DME Specific Peptides for CNP (P09543) (see all 7)
     GEEVGEL  RGKLYSLG  GAEEYAQQ  RKSHTFLPK 

    CNP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_149124.3  
    ENSEMBL proteins: 
     ENSP00000377470   ENSP00000467641   ENSP00000468198   ENSP00000377466   ENSP00000413104  
     ENSP00000466807   ENSP00000468471   ENSP00000465758  

    Human Recombinant Protein Products: 
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    Novus Biologicals CNP Protein
    Novus Biologicals CNP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CNP

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA12379507
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IDA12379507
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005743mitochondrial inner membrane IEA--


    CNP for ontologies           About GeneDecksing



    CNP Antibody Products: 
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    Uscn Antibodies for CNP
    ThermoFisher Antibody for CNP

    Assay Products for CNP: 
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    Uscn ELISAs and CLIAs for CNP

    Protein Domains /
    Families
    for CNP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CNP for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR009097 RNA_ligase/cNuc_Pdiesterase
     IPR008431 CNPase

    Graphical View of Domain Structure for InterPro Entry P09543

    ProtoNet protein and cluster: P09543

    1 Blocks protein family: IPB008431 Cyclic nucleotide phosphodiesterase

    UniProtKB/Swiss-Prot: CN37_HUMAN, P09543
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family


    Function
    for CNP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CN37_HUMAN, P09543
    Function: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central
    nervous system myelin (By similarity)
    Catalytic activity: Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 2'-phosphate

         Genatlas biochemistry entry for CNP:
    2',3' cyclic nucleotide 3'phosphohydrolase,myelin associated,marker of oligodendrocytes and Schwann cells

    Enzyme Number (IUBMB): EC 3.1.4.371 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNP
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate CNP (see all 68):
    hsa-miR-1321 hsa-miR-642a hsa-miR-1224-3p hsa-miR-1245 hsa-miR-200a hsa-miR-550a* hsa-miR-3612 hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmid: CNP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNP (see all 4)
    OriGene shRNA RFP: CNP
    OriGene siRNA: CNP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CNP

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNP 

    Cell Line
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    Search LifeMap BioReagents cell lines for CNP

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:00041132',3'-cyclic-nucleotide 3'-phosphodiesterase activity IEA--
    GO:0030551cyclic nucleotide binding IEA--


    CNP for ontologies           About GeneDecksing


    Animal Models:
         14 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cnp):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle  nervous system 
     reproductive system  respiratory system  skeleton  vision/eye 

    CNP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CNP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    		Neuroscience1.00
    2Selected targets of ESR1
    		Selected targets of ESR11.00
    3Glial Cell Differentiation
    		Glial Cell Differentiation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CNP
        Selected targets of ESR1


    1 Cell Signaling Technology (CST) Pathway for CNP
        Neuroscience

    1 BioSystems Pathway for CNP 
        Glial Cell Differentiation



    CNP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/14 Interacting proteins for CNP (P095433 ENSP000003774704) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    TUBA1AQ71U363, ENSP000003010714I2D: score=2 STRING: ENSP00000301071
    MTNR1AP480393, ENSP000003028114I2D: score=2 STRING: ENSP00000302811
    PTK2Q053973I2D: score=2 
    DDA1Q9BW613I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0007268synaptic transmission TAS1322358
    GO:0007409axonogenesis IEA--
    GO:0007568aging IEA--
    GO:0008344adult locomotory behavior IEA--


    CNP for ontologies           About GeneDecksing



    Drugs & Compounds
    for CNP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CNP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNP

    10 HMDB Compounds for CNP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 2',3'-cyclic phosphatecyclic 2',3'-(hydrogen phosphate)-Adenosine (see all 6)634-01-5--
    Adenosine 2'-phosphate2'-Adenylic acid (see all 3)130-49-4--
    Cytidine 2',3'-cyclic phosphateCyclic(2',3')-CMP (see all 4)15718-51-1--
    Cytidine 2'-phosphate2'-Cytidylic acid (see all 3)85-94-9--
    Guanosine 2',3'-cyclic phosphatecyclic 2',3'-(hydrogen phosphate)-Guanosine (see all 4)15718-49-7--
    Inosine 2',3'-cyclic phosphate2',3' cyclic IMP (see all 5)15569-30-9--
    Inosine 2'-phosphate2'-IMP (see all 3)----
    Uridine 2',3'-cyclic phosphate1-(2,3-O-phosphinico-a-D-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione (see all 4)40632-52-8--
    Uridine 2'-phosphate2'-Uridylic acid (see all 7)131-83-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    8 Novoseek chemical compound relationships for CNP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',3'-cyclic nucleotide 97.7 69 12225906 (2), 12898532 (2), 8011177 (2), 11377758 (2) (see all 58)
    phosphoserine 32.7 1 2166508 (1)
    bromodeoxyuridine 14 2 14625143 (1), 16447750 (1)
    forskolin 11.6 1 2166508 (1)
    adenylate 5.05 1 17522440 (1)
    sucrose 0.637 1 2161932 (1)
    lipid 0 3 10739571 (1), 16480884 (1), 17266109 (1)
    glutamate 0 1 17266109 (1)

    Search CenterWatch for drugs/clinical trials and news about CNP / CN37 

    Transcripts
    for CNP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CNP gene: 
    NM_033133.4  

    Unigene Cluster for CNP:

    2',3'-cyclic nucleotide 3' phosphodiesterase
    Hs.273621  [show with all ESTs]
    Unigene Representative Sequence: NM_033133
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393892(uc002hyl.1 uc010wfz.1 uc002hym.1 uc010wga.1)
    ENST00000472031 ENST00000591945 ENST00000592446 ENST00000587679 ENST00000393888
    ENST00000441615 ENST00000589772 ENST00000585452 ENST00000592861 ENST00000592105
    ENST00000486438 ENST00000591072

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNP
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate CNP (see all 68):
    hsa-miR-1321 hsa-miR-642a hsa-miR-1224-3p hsa-miR-1245 hsa-miR-200a hsa-miR-550a* hsa-miR-3612 hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmid: CNP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNP (see all 4)
    OriGene shRNA RFP: CNP
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK026876.1 AK097833.1 AK098048.1 AK098384.1 AK124861.1 AK294179.1 AK295351.1 AK296534.1 
    AK308696.1 BC001362.2 BC006392.2 BC011046.1 BC028040.1 BC045561.1 M19650.1 

    24/50 DOTS entries (see all 50):

    DT.86999870  DT.40106794  DT.100893655  DT.95292383  DT.120967548  DT.91763414  DT.100696462  DT.452725 
    DT.120967521  DT.100893670  DT.120967368  DT.100893673  DT.120967541  DT.91763422  DT.120967394  DT.91763423 
    DT.95375421  DT.416333  DT.92417479  DT.105058  DT.92035891  DT.120967432  DT.95375432  DT.100045740 

    24/558 AceView cDNA sequences (see all 558):

    AI183611 AW026222 AW516061 BC011046 BU153408 BQ955674 CA427067 BU509651 
    BU194974 CA429556 BU620684 BQ671158 BQ440994 BX419505 BQ648184 BQ680835 
    BF197137 CB153604 BC001362 CR610695 BE884554 CA448084 BQ948228 BM928355 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CNP (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:                                -     -     -     -                                         -     -     -                                 
    SP2:                                -     -     -     -                                         -     -     -                                 
    SP3:                                -     -     -     -     -     -     -     -     -     -     -     -     -                                 
    SP4:                                -     -           -                                                                                       
    SP5:                                                                                                        -                                 


    ECgene alternative splicing isoforms for CNP

    Expression
    for CNP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAATCCTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CNP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNP

    SOURCE GeneReport for Unigene cluster: Hs.273621
        SABiosciences Custom PCR Arrays for CNP
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for CNP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CNP gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cnp1 , 5 2',3'-cyclic nucleotide 3' phosphodiesterase1, 5 85.63(n)1
    85(a)1    		   11 (63.47 cM)5
    127991  NM_009923.21  NP_034053.21 
     1005749045 
    chicken
    (Gallus gallus)    		 Aves CNP1 2',3'-cyclic nucleotide 3' phosphodiesterase 69.22(n)
    67.87(a)    		   395921  NM_205050.1  NP_990381.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CNP6
    		 --
    		 64(a)
    		 1 ↔ 1
    		 6(66410377-66419733)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.88852 Xenopus laevis transcribed sequence with weak similarity more 74.75(n)    BX843487.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BX901973.46
    cnp6
    		 2',3'-cyclic nucleotide 3' phosphodiesterase
    		 32(a)
    31(a)
    		 many → 1
    many → 1
    		 3(17376816-17381225)
    3(17662020-17673215)


    ENSEMBL Gene Tree for CNP (if available)
    TreeFam Gene Tree for CNP (if available) 

    Paralogs
    for CNP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CNP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/176 NCBI SNPs in CNP are shown (see all 176)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1135830761,2
    		C,--40116786(+) CCTCCG/AGGTAG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs80809781,2
    		C,F,--40116817(+) CACCAC/TGCCTG 2 -- us2k1 int13Minor allele frequency- T:0.50NA WA 6
    rs80809791,2
    		C,--40116819(+) CCACGC/GCTGGC 2 -- us2k1 int11Minor allele frequency- G:0.00NA 2
    rs1881844691,2
    		--40116887(+) AACTCC/TTGGCC 1 -- us2k10--------
    rs1167640891,2
    		F,--40116971(+) TGAACA/TAACTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1918416431,2
    		--40117241(+) TGTCAA/GGAGAA 1 -- us2k10--------
    rs1885950901,2
    		--40117329(+) GCCTTC/TGGGAG 1 -- us2k10--------
    rs1492140741,2
    		--40117654(+) GGTGTA/CTTTCA 1 -- us2k10--------
    rs105409261,2
    		C--40117754(+) AAGAA-/AGGGTTT 2 -- us2k1 int10--------
    rs1436017201,2
    		C,--40117754(+) AAGAA-/AGGGTTT 2 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for CNP (40118759 - 40129754 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CNP: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CNP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CNP for disorders           About GeneDecksing

    OMIM gene information: 123830    OMIM disorders: --

    20/32 diseases for CNP (see all 32):    About MalaCards
    beta-mannosidosis    spinal cord injury    pelizaeus-merzbacher disease    niemann-pick disease
    acid sphingomyelinase deficiency    temporal lobe epilepsy    status epilepticus    optic neuritis
    interstitial emphysema    pick's disease    neurofibroma    mannosidosis
    neuritis    hyperphenylalaninemia    hair disease    multiple sclerosis
    cerebral palsy    emphysema    hypothyroidism    down syndrome

    8 Novoseek disease relationships for CNP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    demyelination 62.4 3 15378614 (1), 17618276 (1), 2175632 (1)
    multiple sclerosis 55.8 1 12225906 (1)
    schizophrenia 36.1 23 19348671 (4), 18496213 (3), 17306456 (3), 17964117 (3) (see all 6)
    neurofibroma 26.5 1 16651634 (1)
    glioma 12.6 3 1329795 (1), 7877717 (1), 11453663 (1)
    hypothyroidism 0.0296 2 11592121 (2)
    necrosis 0 1 16109311 (1)
    tumors 0 2 9272635 (1), 16109311 (1)

    Genetic Association Database (GAD): CNP
    Human Genome Epidemiology (HuGE) Navigator: CNP (19 documents)

    Export disorders for CNP gene to outside databases

    Publications
    for CNP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNP gene, integrated from 9 sources (see all 175):
    (articles sorted by number of sources associating them with CNP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The epitope recognized by a monoclonal antibody in the myelin- associated protein CNP. (PubMed id 9268698)1, 2, 9 Stricker R.... Reiser G. (1997)
    2. Crystal structure of the catalytic fragment of human brain 2',3'- cyclic-nucleotide 3'-phosphodiesterase. (PubMed id 15713463)1, 2, 9 Sakamoto Y.... Nakamura K.T. (2005)
    3. Assignment of the human 2',3'-cyclic nucleotide 3'-phosphohydrolase gene to chromosome 17. (PubMed id 1322358)1, 3, 9 Sprinkle T.J....Lapp D.F. (1992)
    4. Structure and chromosomal localization of the human 2',3'-cyclic nucleotide 3'-phosphodiesterase gene. (PubMed id 1360194)1, 2, 9 Douglas A.J....Thompson R.J. (1992)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    6. Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. (PubMed id 16389193)1, 4 Peirce T.R....O'Donovan M.C. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (2003)
    9. A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension. (PubMed id 12452325)1, 4 Ono K....Iwai N. (2002)
    10. Structure, expression and chromosomal localization of the gene encoding human 2',3'-cyclic-nucleotide 3'-phosphodiesterase. (PubMed id 8392017)1, 2 Monoh K.... Shimizu N. (1993)

    External Searches for CNP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CNP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1267 HGNC: 2158 AceView: CNP Ensembl:ENSG00000173786 euGenes: HUgn1267
    ECgene: CNP H-InvDB: CNP

    Other Databases showing CNP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CNP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CNP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CNP gene:
    Search GeneIP for patents involving CNP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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