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Aliases for CNP Gene

Aliases for CNP Gene

  • 2',3'-Cyclic Nucleotide 3' Phosphodiesterase 2
  • 2,3-Cyclic Nucleotide 3 Phosphodiesterase 2 3 5
  • EC 4 61
  • CNPase 3 4
  • 2, 3 Cyclic Nucleotide 3 Phosphohydrolase 3
  • 2,3-Cyclic-Nucleotide 3-Phosphodiesterase 3
  • CNP1 3

External Ids for CNP Gene

Previous GeneCards Identifiers for CNP Gene

  • GC17P039672
  • GC17P042274
  • GC17P040027
  • GC17P040491
  • GC17P037372
  • GC17P040118
  • GC17P035884

Summaries for CNP Gene

GeneCards Summary for CNP Gene

CNP (2',3'-Cyclic Nucleotide 3' Phosphodiesterase) is a Protein Coding gene. Diseases associated with CNP include Niemann-Pick Disease, Type A and Multiple Sclerosis, Disease Progression, Modifier Of. Among its related pathways are Neuroscience and Glial Cell Differentiation. GO annotations related to this gene include RNA binding and cyclic nucleotide binding.

UniProtKB/Swiss-Prot for CNP Gene

  • May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.

Gene Wiki entry for CNP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNP Gene

Genomics for CNP Gene

Regulatory Elements for CNP Gene

Enhancers for CNP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G041798 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -166.2 -166240 3.5 HDGF ARID4B SIN3A ZNF2 SLC30A9 ZNF143 DEK PAF1 ZNF263 SP3 JUP NT5C3B KLHL11 KLHL10 CNP TTC25 KRT19 KRT17 KRT15 KRT16
GH17G042128 1.7 Ensembl ENCODE dbSUPER 10.5 +166.2 166246 8.4 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 DHX58 HSPB9 RAB5C KCNH4 HCRT ZNF385C DNAJC7 NKIRAS2 CNP ENSG00000236194
GH17G042022 1.6 Ensembl ENCODE dbSUPER 11 +57.6 57612 3.6 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A ZNF2 ZNF766 ZNF143 NT5C3B DHX58 ZNF385C CNP DNAJC7 PIR51799
GH17G042015 1.4 ENCODE dbSUPER 11.7 +50.6 50563 2.9 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 CNTNAP1 ENSG00000259623 NT5C3B TUBG2 ENSG00000267758 ENSG00000267765 CNP ZNF385C HSD17B1P1 NAGLU
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNP on UCSC Golden Path with GeneCards custom track

Promoters for CNP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094311 159 1401 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for CNP Gene

41,966,741 bp from pter
41,977,736 bp from pter
10,996 bases
Plus strand

Genomic View for CNP Gene

Genes around CNP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNP Gene

Proteins for CNP Gene

  • Protein details for CNP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    2,3-cyclic-nucleotide 3-phosphodiesterase
    Protein Accession:

    Protein attributes for CNP Gene

    421 amino acids
    Molecular mass:
    47579 Da
    Quaternary structure:
    • Exists as monomers and homodimers.

    Three dimensional structures from OCA and Proteopedia for CNP Gene

    Alternative splice isoforms for CNP Gene


neXtProt entry for CNP Gene

Selected DME Specific Peptides for CNP Gene


Post-translational modifications for CNP Gene

  • Ubiquitination at Lys15, posLast=8787, Lys162, Lys217, Lys261, and posLast=275275
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CNP (CNP)

Domains & Families for CNP Gene

Protein Domains for CNP Gene

Suggested Antigen Peptide Sequences for CNP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 2H phosphoesterase superfamily. CNPase family.
  • Belongs to the 2H phosphoesterase superfamily. CNPase family.
genes like me logo Genes that share domains with CNP: view

No data available for Gene Families for CNP Gene

Function for CNP Gene

Molecular function for CNP Gene

GENATLAS Biochemistry:
2,3 cyclic nucleotide 3phosphohydrolase,myelin associated,marker of oligodendrocytes and Schwann cells
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 2,3-cyclic phosphate + H(2)O = nucleoside 2-phosphate.
UniProtKB/Swiss-Prot Function:
May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.

Enzyme Numbers (IUBMB) for CNP Gene

Gene Ontology (GO) - Molecular Function for CNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004113 2,3-cyclic-nucleotide 3-phosphodiesterase activity IBA,IEA --
GO:0016787 hydrolase activity IEA --
GO:0030551 cyclic nucleotide binding IEA --
genes like me logo Genes that share ontologies with CNP: view
genes like me logo Genes that share phenotypes with CNP: view

Animal Models for CNP Gene

MGI Knock Outs for CNP:
  • Cnp tm1(cre)Kan

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CNP

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNP Gene

Localization for CNP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNP Gene

Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNP gene
Compartment Confidence
extracellular 5
cytoskeleton 5
mitochondrion 4
plasma membrane 3
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for CNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 12379507
GO:0005737 cytoplasm IDA 12379507
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CNP: view

Pathways & Interactions for CNP Gene

genes like me logo Genes that share pathways with CNP: view

Pathways by source for CNP Gene

1 Cell Signaling Technology pathway for CNP Gene

Gene Ontology (GO) - Biological Process for CNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0007268 chemical synaptic transmission TAS 1322358
GO:0007409 axonogenesis IEA --
GO:0007568 aging IEA --
GO:0008344 adult locomotory behavior IEA --
genes like me logo Genes that share ontologies with CNP: view

No data available for SIGNOR curated interactions for CNP Gene

Drugs & Compounds for CNP Gene

(17) Drugs for CNP Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 3836
Risperidone Approved, Investigational Pharma Antagonist SR-2A inhibitor 492
Water Approved Pharma 0
2'-cytidylic acid Experimental Pharma 0
Antipsychotic Agents Pharma 2401

(13) Additional Compounds for CNP Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 2',3'-cyclic phosphate
  • 2',3'-cAMP
  • 2',3'-Cyclic adenosine monophosphate
  • Adenosine 2',3'-cyclic phosphate
  • Adenosine cyclic 2',3'-monophosphate
  • Cyclic 2',3'-(hydrogen phosphate)-Adenosine
Adenosine 2'-phosphate
  • 2'-Adenylic acid
  • Adenosine-2'-monophosphate
  • AMP 2'-Phosphate
Cytidine 2',3'-cyclic phosphate
  • 2',3' Cyclic CMP
  • 2',3' Cyclic-CMP
  • Cyclic(2',3')-CMP
  • Cytidine-2',3'-cyclophosphate
Guanosine 2',3'-cyclic phosphate
  • 2',3' cGMP
  • 2',3'-cGMP
  • 2',3'-Cyclic GMP
  • Cyclic 2',3'-(hydrogen phosphate)-Guanosine
Inosine 2',3'-cyclic phosphate
  • 2',3' Cyclic IMP
  • Inosine cyclic 2',3'-(hydrogen phosphate)
  • Inosine cyclic 2',3'-monophosphate
  • Inosine cyclic 2,3 monophosphate
  • Inosine cyclic-2',3'-monophosphate
genes like me logo Genes that share compounds with CNP: view

Transcripts for CNP Gene

Unigene Clusters for CNP Gene

2,3-cyclic nucleotide 3 phosphodiesterase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CNP

Alternative Splicing Database (ASD) splice patterns (SP) for CNP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - -
SP5: -
SP6: - - - - -
SP7: - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: - -

Relevant External Links for CNP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNP Gene

mRNA differential expression in normal tissues according to GTEx for CNP Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.5) and Brain - Substantia nigra (x5.3).

Protein differential expression in normal tissues from HIPED for CNP Gene

This gene is overexpressed in Frontal cortex (23.2), Brain (19.9), and Spinal cord (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNP Gene

Protein tissue co-expression partners for CNP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNP Gene:


SOURCE GeneReport for Unigene cluster for CNP Gene:


Evidence on tissue expression from TISSUES for CNP Gene

  • Nervous system(5)
  • Skin(4.8)
  • Liver(4.3)
  • Kidney(3.9)
  • Eye(3)
genes like me logo Genes that share expression patterns with CNP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNP Gene

Orthologs for CNP Gene

This gene was present in the common ancestor of animals.

Orthologs for CNP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNP 34 35
  • 99.84 (n)
(Canis familiaris)
Mammalia CNP 34 35
  • 90.29 (n)
(Bos Taurus)
Mammalia CNP 34 35
  • 87.67 (n)
(Rattus norvegicus)
Mammalia Cnp 34
  • 86.35 (n)
(Mus musculus)
Mammalia Cnp 34 16 35
  • 85.63 (n)
(Monodelphis domestica)
Mammalia CNP 35
  • 63 (a)
(Gallus gallus)
Aves CNP 34 35
  • 69.38 (n)
(Anolis carolinensis)
Reptilia CNP 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnp 34
  • 61.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8885 34
(Danio rerio)
Actinopterygii cnp 35 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F26A1.14 35
  • 31 (a)
Species where no ortholog for CNP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNP Gene

Gene Tree for CNP (if available)
Gene Tree for CNP (if available)

Paralogs for CNP Gene

No data available for Paralogs for CNP Gene

Variants for CNP Gene

Sequence variations from dbSNP and Humsavar for CNP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000096123 -- 41,967,975(+) CTTGG(A/G)AAGGC intron-variant
rs1000688978 -- 41,969,266(+) ATTTA(C/T)TCATG intron-variant
rs1001208996 -- 41,969,586(+) AGTCT(C/T)CCTCT intron-variant
rs1001796470 -- 41,975,884(+) CATCC(A/G)TGAGC utr-variant-3-prime
rs1001870381 -- 41,972,351(+) GTTTT(A/G)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNP Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv2056 CNV insertion 18451855
nsv509658 CNV insertion 20534489
nsv953897 CNV deletion 24416366

Variation tolerance for CNP Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNP Gene

Disorders for CNP Gene

MalaCards: The human disease database

(7) MalaCards diseases for CNP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
niemann-pick disease, type a
  • niemann-pick disease type a
multiple sclerosis, disease progression, modifier of
  • multiple sclerosis 1
mannosidosis, beta
  • mannosidosis, beta a, lysosomal
  • hyperphenylalaninemia, non-phenylketonuric
hair disease
  • hair disorder
- elite association - COSMIC cancer census association via MalaCards
Search CNP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CNP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNP Gene

Publications for CNP Gene

  1. No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis. (PMID: 19348671) Che R. … Shi Y. (BMC Med. Genet. 2009) 3 22 46 64
  2. A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. (PMID: 18496213) Voineskos A.N. … Kennedy J.L. (Psychiatr. Genet. 2008) 3 22 46 64
  3. Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population. (PMID: 17306456) Tang F. … Zhang D. (Neurosci. Lett. 2007) 3 22 46 64
  4. The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. (PMID: 17010574) Usui H. … Ozaki N. (Schizophr. Res. 2006) 3 22 46 64
  5. Crystal structure of the catalytic fragment of human brain 2',3'- cyclic-nucleotide 3'-phosphodiesterase. (PMID: 15713463) Sakamoto Y. … Nakamura K.T. (J. Mol. Biol. 2005) 3 4 22 64

Products for CNP Gene

Sources for CNP Gene

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