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Aliases for CNP Gene

Aliases for CNP Gene

  • 2',3'-Cyclic Nucleotide 3' Phosphodiesterase 2
  • 2,3-Cyclic Nucleotide 3 Phosphodiesterase 2 3 5
  • EC 4 61
  • CNPase 3 4
  • 2, 3 Cyclic Nucleotide 3 Phosphohydrolase 3
  • 2,3-Cyclic-Nucleotide 3-Phosphodiesterase 3
  • CNP1 3

External Ids for CNP Gene

Previous GeneCards Identifiers for CNP Gene

  • GC17P039672
  • GC17P042274
  • GC17P040027
  • GC17P040491
  • GC17P037372
  • GC17P040118
  • GC17P035884

Summaries for CNP Gene

GeneCards Summary for CNP Gene

CNP (2',3'-Cyclic Nucleotide 3' Phosphodiesterase) is a Protein Coding gene. Diseases associated with CNP include Niemann-Pick Disease, Type A and Multiple Sclerosis, Disease Progression, Modifier Of. Among its related pathways are Neuroscience and Glial Cell Differentiation. GO annotations related to this gene include RNA binding and cyclic nucleotide binding.

UniProtKB/Swiss-Prot for CNP Gene

  • May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.

Gene Wiki entry for CNP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNP Gene

Genomics for CNP Gene

Regulatory Elements for CNP Gene

Enhancers for CNP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F042049 0.5 FANTOM5 12.5 +82.4 82413 0.2 CNP DNAJC7 NKIRAS2 DHX58 RAB5C HCRT KCNH4 ENSG00000267221 PIR44940
GH17F041989 0.2 ENCODE 11.7 +23.2 23197 0.2 ELF3 ARID4B DMAP1 RAD21 DNMT3B RARA YY1 SCRT2 CREM MIXL1 CNP NKIRAS2 DNAJC7 ZNF385C KLHL11 GC17M041984
GH17F042000 0.4 ENCODE 11.7 +33.9 33949 1.3 HDAC1 RBBP5 ZNF644 RELA FOSL1 ZNF316 ZNF584 NFE2 ZNF639 SMARCE1 NT5C3B DNAJC7 CNP ZNF385C DHX58 HCRT KCNH4 KLHL10 KLHL11 LOC108783654
GH17F041991 0.7 ENCODE 11.7 +25.8 25819 2.1 ZNF121 ZNF664 BCL11B NT5C3B DNAJC7 CNP ZNF385C HCRT KCNH4 KLHL11 DHX58 GC17M041984 NKIRAS2
GH17F041995 0.9 ENCODE 11.7 +29.7 29703 1.6 SCRT1 PKNOX1 OSR2 ZFHX2 SCRT2 EED IKZF1 ZNF600 PRDM1 SPI1 DNAJC7 CNP ZNF385C KCNH4 HCRT KLHL11 NKIRAS2 GC17M041984
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CNP on UCSC Golden Path with GeneCards custom track

Promoters for CNP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001346415 59 2001 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13

Genomic Location for CNP Gene

41,966,741 bp from pter
41,977,736 bp from pter
10,996 bases
Plus strand

Genomic View for CNP Gene

Genes around CNP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNP Gene

Proteins for CNP Gene

  • Protein details for CNP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    2,3-cyclic-nucleotide 3-phosphodiesterase
    Protein Accession:

    Protein attributes for CNP Gene

    421 amino acids
    Molecular mass:
    47579 Da
    Quaternary structure:
    • Exists as monomers and homodimers.

    Three dimensional structures from OCA and Proteopedia for CNP Gene

    Alternative splice isoforms for CNP Gene


neXtProt entry for CNP Gene

Selected DME Specific Peptides for CNP Gene


Post-translational modifications for CNP Gene

  • Ubiquitination at Lys 15, Lys 87, Lys 162, Lys 217, Lys 261, and Lys 275
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CNP (CNP)

Domains & Families for CNP Gene

Protein Domains for CNP Gene

Suggested Antigen Peptide Sequences for CNP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 2H phosphoesterase superfamily. CNPase family.
  • Belongs to the 2H phosphoesterase superfamily. CNPase family.
genes like me logo Genes that share domains with CNP: view

No data available for Gene Families for CNP Gene

Function for CNP Gene

Molecular function for CNP Gene

GENATLAS Biochemistry:
2,3 cyclic nucleotide 3phosphohydrolase,myelin associated,marker of oligodendrocytes and Schwann cells
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 2,3-cyclic phosphate + H(2)O = nucleoside 2-phosphate.
UniProtKB/Swiss-Prot Function:
May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.

Enzyme Numbers (IUBMB) for CNP Gene

Gene Ontology (GO) - Molecular Function for CNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004113 2,3-cyclic-nucleotide 3-phosphodiesterase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0030551 cyclic nucleotide binding IEA --
genes like me logo Genes that share ontologies with CNP: view
genes like me logo Genes that share phenotypes with CNP: view

Animal Models for CNP Gene

MGI Knock Outs for CNP:
  • Cnp tm1(cre)Kan

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNP Gene

Localization for CNP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNP Gene

Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for CNP Gene COMPARTMENTS Subcellular localization image for CNP gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
mitochondrion 4
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 12379507
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 12379507
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with CNP: view

Pathways & Interactions for CNP Gene

genes like me logo Genes that share pathways with CNP: view

Pathways by source for CNP Gene

1 Cell Signaling Technology pathway for CNP Gene
1 BioSystems pathway for CNP Gene

Gene Ontology (GO) - Biological Process for CNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0007268 chemical synaptic transmission TAS 1322358
GO:0007409 axonogenesis IEA --
GO:0007568 aging IEA --
GO:0008344 adult locomotory behavior IEA --
genes like me logo Genes that share ontologies with CNP: view

No data available for SIGNOR curated interactions for CNP Gene

Drugs & Compounds for CNP Gene

(17) Drugs for CNP Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 3759
Risperidone Approved, Investigational Pharma Antagonist SR-2A inhibitor 487
Water Approved Pharma 0
2'-cytidylic acid Experimental Pharma 0
Antipsychotic Agents Pharma 2359

(13) Additional Compounds for CNP Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 2',3'-cyclic phosphate
  • 2',3'-cAMP
  • 2',3'-Cyclic adenosine monophosphate
  • Adenosine 2',3'-cyclic phosphate
  • Adenosine cyclic 2',3'-monophosphate
  • Cyclic 2',3'-(hydrogen phosphate)-Adenosine
Adenosine 2'-phosphate
  • 2'-Adenylic acid
  • Adenosine-2'-monophosphate
  • AMP 2'-Phosphate
Cytidine 2',3'-cyclic phosphate
  • 2',3' Cyclic CMP
  • 2',3' Cyclic-CMP
  • Cyclic(2',3')-CMP
  • Cytidine-2',3'-cyclophosphate
Guanosine 2',3'-cyclic phosphate
  • 2',3' cGMP
  • 2',3'-cGMP
  • 2',3'-Cyclic GMP
  • Cyclic 2',3'-(hydrogen phosphate)-Guanosine
Inosine 2',3'-cyclic phosphate
  • 2',3' Cyclic IMP
  • Inosine cyclic 2',3'-(hydrogen phosphate)
  • Inosine cyclic 2',3'-monophosphate
  • Inosine cyclic 2,3 monophosphate
  • Inosine cyclic-2',3'-monophosphate
genes like me logo Genes that share compounds with CNP: view

Transcripts for CNP Gene

Unigene Clusters for CNP Gene

2,3-cyclic nucleotide 3 phosphodiesterase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - -
SP5: -
SP6: - - - - -
SP7: - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: - -

Relevant External Links for CNP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNP Gene

mRNA differential expression in normal tissues according to GTEx for CNP Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.5) and Brain - Substantia nigra (x5.3).

Protein differential expression in normal tissues from HIPED for CNP Gene

This gene is overexpressed in Frontal cortex (23.2), Brain (19.9), and Spinal cord (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNP Gene

Protein tissue co-expression partners for CNP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNP Gene:


SOURCE GeneReport for Unigene cluster for CNP Gene:

genes like me logo Genes that share expression patterns with CNP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CNP Gene

Orthologs for CNP Gene

This gene was present in the common ancestor of animals.

Orthologs for CNP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNP 34 35
  • 99.84 (n)
(Canis familiaris)
Mammalia CNP 34 35
  • 90.29 (n)
(Bos Taurus)
Mammalia CNP 34 35
  • 87.67 (n)
(Rattus norvegicus)
Mammalia Cnp 34
  • 86.35 (n)
(Mus musculus)
Mammalia Cnp 34 16 35
  • 85.63 (n)
(Monodelphis domestica)
Mammalia CNP 35
  • 63 (a)
(Gallus gallus)
Aves CNP 34 35
  • 69.38 (n)
(Anolis carolinensis)
Reptilia CNP 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnp 34
  • 61.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8885 34
(Danio rerio)
Actinopterygii cnp 35 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F26A1.14 35
  • 31 (a)
Species where no ortholog for CNP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNP Gene

Gene Tree for CNP (if available)
Gene Tree for CNP (if available)

Paralogs for CNP Gene

No data available for Paralogs for CNP Gene

Variants for CNP Gene

Sequence variations from dbSNP and Humsavar for CNP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11079027 -- 41,971,503(+) AAGCA(A/G)TTCTC intron-variant
rs11079028 -- 41,974,115(+) CTCAC(A/G)CTCCC utr-variant-3-prime
rs111437741 -- 41,968,828(+) GATGG(A/T)GCACG intron-variant
rs111525390 -- 41,975,175(+) TCCTA(A/C/G)CTGTG utr-variant-3-prime
rs112245622 -- 41,969,799(+) GATCC(A/G)CTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNP Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv2056 CNV insertion 18451855
nsv509658 CNV insertion 20534489
nsv953897 CNV deletion 24416366

Variation tolerance for CNP Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNP Gene

Disorders for CNP Gene

MalaCards: The human disease database

(6) MalaCards diseases for CNP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
niemann-pick disease, type a
  • niemann-pick disease type a
multiple sclerosis, disease progression, modifier of
  • multiple sclerosis 1
mannosidosis, beta
  • mannosidosis, beta a, lysosomal
  • hyperphenylalaninemia, non-phenylketonuric
hair disease
  • hair disorder
- elite association - COSMIC cancer census association via MalaCards
Search CNP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CNP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNP Gene

Publications for CNP Gene

  1. No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis. (PMID: 19348671) Che R. … Shi Y. (BMC Med. Genet. 2009) 3 22 46 64
  2. A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. (PMID: 18496213) Voineskos A.N. … Kennedy J.L. (Psychiatr. Genet. 2008) 3 22 46 64
  3. Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population. (PMID: 17306456) Tang F. … Zhang D. (Neurosci. Lett. 2007) 3 22 46 64
  4. The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. (PMID: 17010574) Usui H. … Ozaki N. (Schizophr. Res. 2006) 3 22 46 64
  5. Crystal structure of the catalytic fragment of human brain 2',3'- cyclic-nucleotide 3'-phosphodiesterase. (PMID: 15713463) Sakamoto Y. … Nakamura K.T. (J. Mol. Biol. 2005) 3 4 22 64

Products for CNP Gene

Sources for CNP Gene

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