Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CNP Gene

protein-coding   GIFtS: 63
GCID: GC17P040118

2',3'-Cyclic Nucleotide 3' Phosphodiesterase

  See CNP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
2',3'-Cyclic Nucleotide 3' Phosphodiesterase1 2
CNPase2 3
EC 3.1.4.373 8
CNP12 5
2', 3' Cyclic Nucleotide 3' Phosphohydrolase2
2',3'-Cyclic-Nucleotide 3'-Phosphodiesterase2

External Ids:    HGNC: 21581   Entrez Gene: 12672   Ensembl: ENSG000001737867   OMIM: 1238305   UniProtKB: P095433   

Export aliases for CNP gene to outside databases

Previous GC identifers: GC17P039672 GC17P042274 GC17P040027 GC17P040491 GC17P037372 GC17P035884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CNP Gene:
CNP (2',3'-cyclic nucleotide 3' phosphodiesterase) is a protein-coding gene. Diseases associated with CNP include hair disease, and beta-mannosidosis. GO annotations related to this gene include RNA binding and 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity.

UniProtKB/Swiss-Prot: CN37_HUMAN, P09543
Function: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in
central nervous system myelin (By similarity)

Gene Wiki entry for CNP (2',3'-Cyclic-nucleotide 3'-phosphodiesterase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNP gene promoter:
         C/EBPbeta   Tal-1   p53   MyoD   LUN-1   HNF-4alpha2   HNF-4alpha1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNP promoter sequence
   Search Chromatin IP Primers for CNP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21

CNP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNP gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040118:  view genomic region     (about GC identifiers)

Start:
40,118,759 bp from pter      End:
40,129,754 bp from pter
Size:
10,996 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003571052 253,383-264,378     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CN37_HUMAN, P09543 (See protein sequence)
Recommended Name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase precursor  
Size: 421 amino acids; 47579 Da
Subunit: Exists as monomers and homodimers (By similarity)
1 PDB 3D structure from and Proteopedia for CNP:
1WOJ (3D)    
Alternative splicing: 2 isoforms:  P09543-1   P09543-2   

Explore the universe of human proteins at neXtProt for CNP: NX_P09543

Explore proteomics data for CNP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys15, Lys87, Lys162, Lys217, Lys261, Lys275
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CNP (P09543) (see all 7)
     GEEVGEL  RGKLYSLG  GAEEYAQQ  RKSHTFLPK 


    See CNP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149124.3  
    ENSEMBL proteins: 
     ENSP00000377470   ENSP00000467641   ENSP00000468198   ENSP00000377466   ENSP00000413104  
     ENSP00000466807   ENSP00000468471   ENSP00000465758  

    CNP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CNP
    OriGene Protein Over-expression Lysate for CNP
    OriGene MassSpec for CNP
    OriGene Custom Protein Services for CNP
    GenScript Custom Purified and Recombinant Proteins Services for CNP
    Novus Biologicals CNP Protein
    Novus Biologicals CNP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNP

     
    Search eBioscience for Proteins for CNP 

     
    antibodies-online proteins for CNP (2 products) 

     
    antibodies-online peptides for CNP

    CNP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CNP
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CNP 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CNP
    Novus Biologicals CNP Antibodies
    Abcam antibodies for CNP
    Cloud-Clone Corp. Antibodies for CNP
    ThermoFisher Antibody for CNP
    antibodies-online antibodies for CNP (83 products) 

    CNP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CNP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CNP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNP
    Cloud-Clone Corp. CLIAs for CNP
    Search eBioscience for ELISAs for CNP 
    antibodies-online kits for CNP (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR009097 RNA_ligase/cNuc_Pdiesterase
     IPR008431 CNPase

    Graphical View of Domain Structure for InterPro Entry P09543

    ProtoNet protein and cluster: P09543

    1 Blocks protein domain: IPB008431 Cyclic nucleotide phosphodiesterase

    UniProtKB/Swiss-Prot: CN37_HUMAN, P09543
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family


    Find genes that share domains with CNP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CN37_HUMAN, P09543
    Function: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in
    central nervous system myelin (By similarity)
    Catalytic activity: Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 2'-phosphate

         Genatlas biochemistry entry for CNP:
    2',3' cyclic nucleotide 3'phosphohydrolase,myelin associated,marker of oligodendrocytes and Schwann cells

         Enzyme Number (IUBMB): EC 3.1.4.371 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0003824catalytic activity ----
    GO:00041132',3'-cyclic-nucleotide 3'-phosphodiesterase activity IEA--
    GO:0005524ATP binding ----
    GO:0016301kinase activity ----
         
    Find genes that share ontologies with CNP           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cnp):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle  nervous system 
     reproductive system  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with CNP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CNP

    miRNA
    Products:
        
    miRTarBase miRNAs that target CNP:
    hsa-mir-874-3p (MIRT037760), hsa-mir-124-3p (MIRT022857), hsa-mir-16-5p (MIRT051255), hsa-mir-345-5p (MIRT042728), hsa-mir-615-3p (MIRT040114), hsa-mir-30a-5p (MIRT049951)

    Block miRNA regulation of human, mouse, rat CNP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNP (see all 68):
    hsa-miR-1321 hsa-miR-642a hsa-miR-1224-3p hsa-miR-1245 hsa-miR-200a hsa-miR-550a* hsa-miR-3612 hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmidCNP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CNP
    Predesigned siRNA for gene silencing in human, mouse, rat CNP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CNP

    Clone
    Products:
         
    OriGene clones in human, mouse for CNP (see all 8)
    OriGene ORF clones in mouse, rat for CNP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNP (NM_033133)
    Sino Biological Human cDNA Clone for CNP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CNP
    Browse ESI BIO Cell Lines and PureStem Progenitors for CNP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CN37_HUMAN, P09543: Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white
    matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular4
    mitochondrion2
    plasma membrane2
    cytosol1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA12379507
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005741mitochondrial outer membrane IEA--

    Find genes that share ontologies with CNP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CNP About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of ESR1
    Selected targets of ESR1
    2Neuroscience
    Neuroscience
    3Glial Cell Differentiation
    Glial Cell Differentiation


    Find genes that share SuperPaths with CNP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CNP
        Neuroscience

    1 BioSystems Pathway for CNP
        Glial Cell Differentiation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNP
    Interactions:

        GeneGlobe Interaction Network for CNP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for CNP (P095433 ENSP000003774704) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    TUBA1AQ71U363, ENSP000003010714I2D: score=2 STRING: ENSP00000301071
    MTNR1AP480393, ENSP000003028114I2D: score=2 STRING: ENSP00000302811
    PTK2Q053973I2D: score=2 
    DDA1Q9BW613I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0007268synaptic transmission TAS1322358
    GO:0007409axonogenesis IEA--
    GO:0007568aging IEA--
    GO:0008344adult locomotory behavior IEA--

    Find genes that share ontologies with CNP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNP (CN37)

    10 HMDB Compounds for CNP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 2',3'-cyclic phosphatecyclic 2',3'-(hydrogen phosphate)-Adenosine (see all 6)634-01-5--
    Adenosine 2'-phosphate2'-Adenylic acid (see all 3)130-49-4--
    Cytidine 2',3'-cyclic phosphateCyclic(2',3')-CMP (see all 4)15718-51-1--
    Cytidine 2'-phosphate2'-Cytidylic acid (see all 3)85-94-9--
    Guanosine 2',3'-cyclic phosphatecyclic 2',3'-(hydrogen phosphate)-Guanosine (see all 4)15718-49-7--
    Inosine 2',3'-cyclic phosphate2',3' cyclic IMP (see all 5)15569-30-9--
    Inosine 2'-phosphate2'-IMP (see all 3)----
    Uridine 2',3'-cyclic phosphate1-(2,3-O-phosphinico-a-D-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione (see all 4)40632-52-8--
    Uridine 2'-phosphate2'-Uridylic acid (see all 7)131-83-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    8 Novoseek inferred chemical compound relationships for CNP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',3'-cyclic nucleotide 97.7 69 12225906 (2), 12898532 (2), 8011177 (2), 11377758 (2) (see all 58)
    phosphoserine 32.7 1 2166508 (1)
    bromodeoxyuridine 14 2 14625143 (1), 16447750 (1)
    forskolin 11.6 1 2166508 (1)
    adenylate 5.05 1 17522440 (1)
    sucrose 0.637 1 2161932 (1)
    lipid 0 3 10739571 (1), 16480884 (1), 17266109 (1)
    glutamate 0 1 17266109 (1)



    Find genes that share compounds with CNP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CNP gene: 
    NM_033133.4  

    Unigene Cluster for CNP:

    2',3'-cyclic nucleotide 3' phosphodiesterase
    Hs.273621  [show with all ESTs]
    Unigene Representative Sequence: NM_033133
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393892(uc002hyl.1 uc010wfz.1 uc002hym.1 uc010wga.1)
    ENST00000472031 ENST00000591945 ENST00000592446 ENST00000587679 ENST00000393888
    ENST00000441615 ENST00000589772 ENST00000585452 ENST00000592861 ENST00000592105
    ENST00000486438 ENST00000591072
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CNP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNP (see all 68):
    hsa-miR-1321 hsa-miR-642a hsa-miR-1224-3p hsa-miR-1245 hsa-miR-200a hsa-miR-550a* hsa-miR-3612 hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmidCNP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CNP
    Predesigned siRNA for gene silencing in human, mouse, rat CNP
    Clone
    Products:
         
    OriGene clones in human, mouse for CNP (see all 8)
    OriGene ORF clones in mouse, rat for CNP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNP (NM_033133)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CNP
    OriGene qSTAR qPCR primer pairs in human, mouse for CNP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNP
      QuantiTect SYBR Green Assays in human, mouse, rat CNP
      QuantiFast Probe-based Assays in human, mouse, rat CNP

    Additional mRNA sequence: 

    AK026876.1 AK097833.1 AK098048.1 AK098384.1 AK124861.1 AK294179.1 AK295351.1 AK296534.1 
    AK308696.1 BC001362.2 BC006392.2 BC011046.1 BC028040.1 BC045561.1 BC148241.1 M19650.1 

    Selected DOTS entries (see all 54):

    DT.86999870  DT.40106794  DT.100893655  DT.95292383  DT.120967548  DT.91763414  DT.452725  DT.100696462 
    DT.120967521  DT.100893670  DT.120967368  DT.100893673  DT.120967541  DT.91763423  DT.91763422  DT.120967394 
    DT.92417479  DT.416333  DT.95375421  DT.105058  DT.92035891  DT.100683725  DT.100893664  DT.120967432 

    Selected AceView cDNA sequences (see all 558):

    BQ653293 BM691849 BU162692 BE255264 BU196279 BQ683744 BM757286 BQ671158 
    BM800463 BM740888 CR610695 BU509651 M61958 BQ677093 BU156955 BM449647 
    BU157398 CA448084 BF197137 BQ679138 BM462553 CD671725 AW316805 AA378818 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNP (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:                                -     -     -     -                                         -     -     -                                 
    SP2:                                -     -     -     -                                         -     -     -                                 
    SP3:                                -     -     -     -     -     -     -     -     -     -     -     -     -                                 
    SP4:                                -     -           -                                                                                       
    SP5:                                                                                                        -                                 


    ECgene alternative splicing isoforms for CNP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CNP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATCCTAA
    CNP Expression
    About this image


    CNP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Spinal Cord White Matter
             Oligodendrocyte-like cells
     
     Peripheral Nervous System (Nervous System)
             Schwann-like cells
     
     Schwann Cells (Nervous System)
             Schwann-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
    CNP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.273621
        Custom PCR Arrays for CNP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CNP
    OriGene qSTAR qPCR primer pairs in human, mouse for CNP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNP
    QuantiTect SYBR Green Assays in human, mouse, rat CNP
    QuantiFast Probe-based Assays in human, mouse, rat CNP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CNP gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnp1 , 5 2',3'-cyclic nucleotide 3' phosphodiesterase1, 5 85.63(n)1
    85(a)1
      11 (63.47 cM)5
    127991  NM_009923.21  NP_034053.21 
     1005749045 
    chicken
    (Gallus gallus)
    Aves CNP1 2',3'-cyclic nucleotide 3' phosphodiesterase 69.38(n)
    68.11(a)
      395921  NM_205050.1  NP_990381.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNP6
    2',3'-cyclic nucleotide 3' phosphodiesterase
    65(a)
    1 ↔ 1
    6(66410377-66419733)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.88852 Xenopus laevis transcribed sequence with weak similarity more 74.75(n)    BX843487.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cnp6
    cnp6
    2',3'-cyclic nucleotide 3' phosphodiesterase
    31(a)
    30(a)
    1 ↔ many
    1 ↔ many
    3(17662020-17673215) ENSDARG00000091351
    3(17376816-17381225) ENSDARG00000070822
    worm
    (Caenorhabditis elegans)
    Secernentea F26A1.146
    Protein F26A1.14 (F26A1.14) mRNA, complete cds
    31(a)
    1 ↔ 1
    III(4849266-4849850) WBGene00017812


    ENSEMBL Gene Tree for CNP (if available)
    TreeFam Gene Tree for CNP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CNP (see all 218)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1135830761,2
    C,F--40116786(+) CCTCCG/AGGTAG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1881844691,2
    --40116887(+) AACTCC/TTGGCC 1 -- us2k10--------
    rs1167640891,2
    C,F--40116971(+) TGAACA/TAACTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1918416431,2
    C--40117241(+) TGTCAA/GGAGAA 1 -- us2k10--------
    rs1885950901,2
    --40117329(+) GCCTTC/TGGGAG 1 -- us2k10--------
    rs1492140741,2
    --40117654(+) GGTGTA/CTTTCA 1 -- us2k10--------
    rs1434076231,2
    --40117940(+) AGGTAA/GGAGAA 1 -- us2k10--------
    rs1821852831,2
    --40118328(+) TGAGAA/CTGACT 1 -- us2k10--------
    rs1867134741,2
    --40118525(+) GACCCA/TGCCTC 1 -- us2k10--------
    rs129529151,2
    C,F--40118552(+) TCCACG/AGGACC 1 -- us2k17Minor allele frequency- A:0.17NA WA EA 366

    HapMap Linkage Disequilibrium report for CNP (40118759 - 40129754 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CNP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509658CNV Insertion20534489
    nsv2056CNV Insertion18451855
    nsv908239CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNP
    DNA2.0 Custom Variant and Variant Library Synthesis for CNP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 123830    OMIM disorders: --

    3 diseases for CNP:    
    About MalaCards
    hair disease    beta-mannosidosis    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for CNP:
    Multiple sclerosis     beta-mannosidosis

    Find genes that share disorders with CNP           About GenesLikeMe

    8 Novoseek inferred disease relationships for CNP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    demyelination 62.4 3 15378614 (1), 17618276 (1), 2175632 (1)
    multiple sclerosis 55.8 1 12225906 (1)
    schizophrenia 36.1 23 19348671 (4), 18496213 (3), 17306456 (3), 17964117 (3) (see all 6)
    neurofibroma 26.5 1 16651634 (1)
    glioma 12.6 3 1329795 (1), 7877717 (1), 11453663 (1)
    hypothyroidism 0.0296 2 11592121 (2)
    necrosis 0 1 16109311 (1)
    tumors 0 2 9272635 (1), 16109311 (1)

    Genetic Association Database (GAD): CNP
    Human Genome Epidemiology (HuGE) Navigator: CNP (19 documents)

    Export disorders for CNP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CNP gene, integrated from 10 sources (see all 187):
    (articles sorted by number of sources associating them with CNP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis. (PubMed id 19348671)1, 4, 9 Che R....Shi Y. (BMC Med. Genet. 2009)
    2. Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population. (PubMed id 17306456)1, 4, 9 Tang F....Zhang D. (Neurosci. Lett. 2007)
    3. The epitope recognized by a monoclonal antibody in the myelin- associated protein CNP. (PubMed id 9268698)1, 2, 9 Stricker R.... Reiser G. (Biochem. Biophys. Res. Commun. 1997)
    4. Crystal structure of the catalytic fragment of human brain 2',3'- cyclic-nucleotide 3'-phosphodiesterase. (PubMed id 15713463)1, 2, 9 Sakamoto Y.... Nakamura K.T. (J. Mol. Biol. 2005)
    5. A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. (PubMed id 18496213)1, 4, 9 Voineskos A.N....Kennedy J.L. (Psychiatr. Genet. 2008)
    6. The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. (PubMed id 17010574)1, 4, 9 Usui H....Ozaki N. (Schizophr. Res. 2006)
    7. Assignment of the human 2',3'-cyclic nucleotide 3'-phosphohydrolase gene to chromosome 17. (PubMed id 1322358)1, 3, 9 Sprinkle T.J....Lapp D.F. (Genomics 1992)
    8. Structure and chromosomal localization of the human 2',3'-cyclic nucleotide 3'-phosphodiesterase gene. (PubMed id 1360194)1, 2, 9 Douglas A.J....Thompson R.J. (Ann. Hum. Genet. 1992)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1267 HGNC: 2158 AceView: CNP Ensembl:ENSG00000173786 euGenes: HUgn1267
    ECgene: CNP H-InvDB: CNP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CNP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CNP gene:
    Search GeneIP for patents involving CNP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of CNP
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CNP  
     OriGene qPCR primer pairs and template standards for CNP   OriGene Protein Over-expression Lysate for CNP  
     OriGene MassSpec for CNP   OriGene clones in human, mouse for CNP  
     OriGene qSTAR qPCR primer pairs in human, mouse for CNP   OriGene Purified Protein for CNP  
     OriGene ORF clones in mouse, rat for CNP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CNP   OriGene Custom Protein Services for CNP  

     
     
     Block miRNA regulation of human, mouse, rat CNP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CNP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNP Predesigned siRNA for gene silencing in human, mouse, rat CNP
     QuantiFast Probe-based Assays in human, mouse, rat CNP QuantiTect SYBR Green Assays in human, mouse, rat CNP
     Custom PCR Arrays for CNP Search Chromatin IP Primers for CNP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNP  GeneGlobe Interaction Network for CNP
     Regulatory tfbs in CNP promoter
     GenScript Custom Purified and Recombinant Proteins Services for CNP GenScript cDNA clones with any tag delivered in your preferred vector for CNP
     GenScript Custom Assay Services for CNP GenScript Custom overexpressing Cell Line Services for CNP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for CNP 

     Search Tocris compounds for CNP (CN37)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CNP
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CNP antibodies
     CNP proteins
     CNP lysates
     Antibodies for CNP
     See all of Abcam's Antibodies, Kits and Proteins for CNP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CNP
     Antibodies for CNP
     ELISAs for CNP
     CLIAs for CNP



     Browse ESI BIO Cell Lines and PureStem Progenitors for CNP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNP
     SwitchGear 3'UTR luciferase reporter plasmids for CNP
     SwitchGear Promoter luciferase reporter plasmids for CNP
     ThermoFisher Antibody for CNP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNP
     Browse compounds at ApexBio
     Search Addgene for plasmids for CNP
      Search eBioscience for proteins for CNP
      Search eBioscience for elisas for CNP
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CNP
     antibodies-online antibodies for CNP (83 products)
     antibodies-online kits for CNP (11 products)
     antibodies-online peptides for CNP
     antibodies-online proteins for CNP (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CNP gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4