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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNOT8 Gene

protein-coding   GIFtS: 62
GCID: GC05P154218

CCR4-NOT Transcription Complex, Subunit 8


(Previous symbol: POP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CCR4-NOT Transcription Complex, Subunit 81 2     CAF1-Like Protein2 3
POP21 2 3 5     CCR4-Associated Factor 82 3
CALIF2 3 5     CAF12
PGK Promoter Directed Over Production1 2     CCR4-NOT Transcription Complex Subunit 82
CAF22 3     hCAF12
CALIFp2 3     EC 3.1.13.43
Caf1b2 3     

External Ids:    HGNC: 92071   Entrez Gene: 93372   Ensembl: ENSG000001555087   OMIM: 6037315   UniProtKB: Q9UFF93   

Export aliases for CNOT8 gene to outside databases

Previous GC identifers: GC05P154331 GC05P154833 GC05P154221 GC05P154266 GC05P149380


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CNOT8 Gene: 
CNOT8 (CCR4-NOT transcription complex, subunit 8) is a protein-coding gene. Diseases associated with CNOT8 include microsporidiosis, and dental fluorosis, and among its related super-pathways are Deadenylation-dependent mRNA decay and Metabolism of RNA. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and nucleic acid binding. An important paralog of this gene is CNOT7.

UniProtKB/Swiss-Prot: CNOT8_HUMAN, Q9UFF9
Function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be
partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various
cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during
translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems
also to act as translational repressor during translational initiation. Additional complex functions may be a
consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2
and is required for their anti-proliferative activity

Gene Wiki entry for CNOT8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNOT8 gene promoter:
         LHX3b/Lhx3b   FOXD1   HNF-4alpha2   HNF-3beta   HNF-4alpha1   GATA-1   N-Myc   USF-1   LHX3a/Lhx3a   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNOT8 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNOT8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31-q33   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q31-q33

CNOT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT8 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P154218:  view genomic region     (about GC identifiers)

Start:
154,237,113 bp from pter      End:
154,256,353 bp from pter
Size:
19,241 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNOT8_HUMAN, Q9UFF9 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 8  
Size: 292 amino acids; 33540 Da
Subunit: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of
probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L,
and CNOT7 or CNOT8. In the complex interacts directly with CNOT1. Interacts with BTG1, BTG2 and TOB1
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B2RAR8 D3DQI8 O95709 Q7Z521 Q9H6Y1

Explore the universe of human proteins at neXtProt for CNOT8: NX_Q9UFF9

Explore proteomics data for CNOT8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UFF9

  • CNOT8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNOT8 Protein Expression
    REFSEQ proteins: NP_004770.4  
    ENSEMBL proteins: 
     ENSP00000428565   ENSP00000430493   ENSP00000430215   ENSP00000429108   ENSP00000428550  
     ENSP00000428359   ENSP00000431034   ENSP00000384747   ENSP00000428090   ENSP00000429576  
     ENSP00000285896   ENSP00000429310   ENSP00000428305   ENSP00000429882   ENSP00000429810  
     ENSP00000430833   ENSP00000428842   ENSP00000428600   ENSP00000429394   ENSP00000428576  
    Reactome Protein details: Q9UFF9
    Human Recombinant Protein Products for CNOT8: 
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    Novus Biologicals CNOT8 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNOT8 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus NAS10036195
    GO:0005829cytosol TAS--
    GO:0030014CCR4-NOT complex IDA19558367

    CNOT8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR006941 RNase_CAF1
     IPR027212 Cnot8
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UFF9

    ProtoNet protein and cluster: Q9UFF9

    1 Blocks protein domain: IPB006941 CAF1 family ribonuclease

    UniProtKB/Swiss-Prot: CNOT8_HUMAN, Q9UFF9
    Similarity: Belongs to the CAF1 family


    CNOT8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNOT8_HUMAN, Q9UFF9
    Function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be
    partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various
    cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during
    translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems
    also to act as translational repressor during translational initiation. Additional complex functions may be a
    consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2
    and is required for their anti-proliferative activity
    Catalytic activity: Exonucleolytic cleavage of poly(A) to 5'-AMP

         Enzyme Number (IUBMB): EC 3.1.13.41

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00001753'-5'-exoribonuclease activity IDA15769875
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10036195
    GO:0003723RNA binding IEA--
    GO:0004535poly(A)-specific ribonuclease activity IDA15769875
         
    CNOT8 for ontologies           About GeneDecksing


    Animal Models:
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT8 (see all 17):
    hsa-miR-607 hsa-miR-520d-5p hsa-miR-29c hsa-miR-29a hsa-miR-374a hsa-miR-511 hsa-miR-548x hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidCNOT8 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CNOT8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.49
    Deadenylation of mRNA0.47
    RNA degradation0.49
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for CNOT8
        Deadenylation of mRNA
    Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    1         Kegg Pathway  (Kegg details for CNOT8):
        RNA degradation


    CNOT8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNOT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/132 Interacting proteins for CNOT8 (Q9UFF91, 2, 3 ENSP000002858964) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT3O751751, 2, 3, ENSP000002212324EBI-742299,EBI-743073 MINT-2835097 I2D: score=9 STRING: ENSP00000221232
    CNOT2Q9NZN82, 3, ENSP000002291954MINT-2835112 MINT-2835127 I2D: score=2 STRING: ENSP00000229195
    ENSG00000206286Q8N1B43I2D: score=1 
    ENSG00000224455Q8N1B43I2D: score=1 
    ENSG00000225590Q8N1B43I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS10036195
    GO:0006417regulation of translation IEA--

    CNOT8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNOT8

    Search CenterWatch for drugs/clinical trials and news about CNOT8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNOT8 gene: 
    NM_004779.4  

    Unigene Cluster for CNOT8:

    CCR4-NOT transcription complex, subunit 8
    Hs.26703  [show with all ESTs]
    Unigene Representative Sequence: NM_004779
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000521174 ENST00000523270 ENST00000518782 ENST00000523698 ENST00000517876(uc003lvu.3 uc011ddf.2)
    ENST00000520472 ENST00000519211 ENST00000522458 ENST00000519903 ENST00000521450
    ENST00000403027(uc011ddg.2 uc011ddh.2 uc003lvv.3 uc010jig.3 uc010jif.3 uc003lvw.3 uc011ddi.2)
    ENST00000517568 ENST00000524105 ENST00000285896(uc011ddj.2) ENST00000519430
    ENST00000520671 ENST00000521583 ENST00000518028
    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT8 (see all 17):
    hsa-miR-607 hsa-miR-520d-5p hsa-miR-29c hsa-miR-29a hsa-miR-374a hsa-miR-511 hsa-miR-548x hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmidCNOT8 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF053318.1 AF087844.1 AF180476.1 AK025358.1 AK297381.1 AK299589.1 AK303775.1 AK309359.1 
    AK314317.1 AK315864.1 AK316055.1 AK316221.1 AK316269.1 AL122045.1 BC017366.2 BC093025.1 
    BT006857.1 BX647124.1 

    24 DOTS entries:

    DT.100714866  DT.100714888  DT.100714853  DT.95159482  DT.95159456  DT.118487  DT.91809419  DT.95229239 
    DT.100862530  DT.91836207  DT.100714872  DT.100861380  DT.120820892  DT.95159466  DT.102824084  DT.120820982 
    DT.91675955  DT.92415471  DT.95118078  DT.118488  DT.120820769  DT.120821116  DT.85100580  DT.92016957 

    24/310 AceView cDNA sequences (see all 310):

    AA765235 AI142462 AW614202 BE396911 BM720696 AL122045 AA781325 AA962304 
    AI754002 AI927853 AI914837 AL040729 BU633518 BM698013 AI918361 BU619651 
    BU193222 AW271303 AI918556 AA761919 BU622056 BM763533 BU684012 AV717763 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT8 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a ·
    SP1:                                                                    -     -     -     -     -     -     -     -     -                                   -   
    SP2:                                                                                -     -     -     -     -     -     -                                   -   
    SP3:                                                                    -     -     -     -     -     -     -     -     -     -     -     -                 -   
    SP4:                                                                                -     -     -     -     -     -     -     -     -     -                 -   
    SP5:                                -     -                             -     -     -     -     -     -     -     -     -                                   -   

    ExUns: 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e
    SP1:  -                                                         
    SP2:  -                                                         
    SP3:  -                                                         
    SP4:  -                                                         
    SP5:  -                                                         


    ECgene alternative splicing isoforms for CNOT8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNOT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTTGTAT
    CNOT8 Expression
    About this image


    See CNOT8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNOT8

    SOURCE GeneReport for Unigene cluster: Hs.26703
        SABiosciences Custom PCR Arrays for CNOT8
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNOT8 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnot81 , 5 CCR4-NOT transcription complex, subunit 81, 5 88.47(n)1
    99.32(a)1
      11 (35.69 cM)5
    691251  NM_026949.31  NP_081225.11 
     581041535 
    chicken
    (Gallus gallus)
    Aves CNOT81 CCR4-NOT transcription complex, subunit 8 84.08(n)
    97.94(a)
      416255  NM_001030618.1  NP_001025789.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNOT86
    Uncharacterized protein
    97(a)
    1 ↔ 1
    GL343205.1(799692-807819)
    African clawed frog
    (Xenopus laevis)
    Amphibia cnot8-prov2 CCR4-NOT transcription complex, subunit 8 78.75(n)    BC041239.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe49a052 Danio rerio cDNA clone MGC63844 IMAGE3817507, complete more 78.44(n)    BC055263.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56843 general RNA polymerase II
    transcription factor
    72(a)   68F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea ccf-16
    CCR4-NOT transcription complex subunit 7
    42(a)
    1 → many
    III(11918827-11920242)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POP2(YNR052C)4 RNase of the DEDD superfamily, subunit of the Ccr4-Not more   --   14(720647-719346) 855788  NP_014450.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.45842 Vitis vinifera transcribed sequence with moderate similarity more 72.98(n)    CB971079.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04168001 hypothetical protein 53.77(n)
    53.64(a)
      4347066  NM_001069716.1  NP_001063181.1 


    ENSEMBL Gene Tree for CNOT8 (if available)
    TreeFam Gene Tree for CNOT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNOT8 gene
    CNOT72  
    1 SIMAP similar gene for CNOT8 using alignment to 14 protein entries:     CNOT8_HUMAN (see all proteins):
    CNOT7

    CNOT8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CNOT8
    PGOHUM00000245938


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/386 SNPs in CNOT8 are shown (see all 386)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs26882021,2
    C,F--154236269(-) CACTGC/TACTCC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs49583911,2
    H--154236380(+) cccagC/Ataatt 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs768738381,2
    C--154236422(-) TGGCCG/AACATG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1436750541,2
    C--154236692(+) ATTTGC/G/TGGGGG 1 -- us2k10--------
    rs1468086111,2
    --154236693(+) TTTGGC/GGGGGA 1 -- us2k10--------
    rs37769841,2
    C,F,H--154236694(-) CTCCCC/TCCCAA 1 -- us2k116Minor allele frequency- T:0.07EA NS WA NA 3822
    rs1924042601,2
    --154236724(+) AGAAAA/GTGCAT 1 -- us2k10--------
    rs1160279071,2
    C,F--154236792(+) GGAATC/TCCGTT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1489856031,2
    --154237269(+) GTCTCG/TACACT 1 -- us2k10--------
    rs1837392761,2
    --154237320(+) AGCTCA/TGAAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNOT8 (154237113 - 154256353 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CNOT8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830521CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603731    OMIM disorders: --

    4 diseases for CNOT8:    About MalaCards
    microsporidiosis    dental fluorosis    dental caries    candidiasis

    3 diseases from the University of Copenhagen DISEASES database for CNOT8:
    Dental caries     Microsporidiosis     Candidiasis

    CNOT8 for disorders           About GeneDecksing


    Export disorders for CNOT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNOT8 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with CNOT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 2, 3, 9 Albert T.K....Timmers H.T. (2000)
    2. The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome. (PubMed id 10036195)1, 2, 3 Fidler C.... Boultwood J. (1999)
    3. The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 hav e overlapping roles and modulate cell proliferation. (PubMed id 19605561)1, 2, 9 Aslam A....Winkler G.S. (2009)
    4. Conservation of the deadenylase activity of proteins of the Caf1 family in human. (PubMed id 15769875)1, 2, 9 Bianchin C....Corbo L. (2005)
    5. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PubMed id 11136725)1, 2, 9 Prevot D....Corbo L. (2001)
    6. CCR4-NOT deadenylates mRNA associated with RNA-induce d silencing complexes in human cells. (PubMed id 20065043)1, 2, 9 Piao X....Belasco J.G. (2010)
    7. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4- not complex. (PubMed id 23236473)1, 2 Doidge R.... Winkler G.S. (2012)
    8. Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)1, 2 Lau N.C....Timmers H.T. (2009)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9337 HGNC: 9207 AceView: CNOT8 Ensembl:ENSG00000155508 euGenes: HUgn9337
    ECgene: CNOT8 Kegg: 9337 H-InvDB: CNOT8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNOT8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CNOT8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNOT8 gene:
    Search GeneIP for patents involving CNOT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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