Aliases for CNOT8 Gene
External Ids for CNOT8 Gene
Previous HGNC Symbols for CNOT8 Gene
Previous GeneCards Identifiers for CNOT8 Gene
GeneCards Summary for CNOT8 Gene
CNOT8 (CCR4-NOT Transcription Complex, Subunit 8) is a Protein Coding gene. Diseases associated with CNOT8 include microsporidiosis. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and 3-5-exoribonuclease activity. An important paralog of this gene is CNOT7.
UniProtKB/Swiss-Prot for CNOT8 Gene
Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.