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Aliases for CNOT8 Gene

Aliases for CNOT8 Gene

  • CCR4-NOT Transcription Complex Subunit 8 2 3 5
  • PGK Promoter Directed Over Production 2 3
  • CCR4-Associated Factor 8 3 4
  • CAF1-Like Protein 3 4
  • CALIFp 3 4
  • CAF1B 3 4
  • CALIF 3 4
  • POP2 3 4
  • CAF2 3 4
  • CCR4-NOT Transcription Complex, Subunit 8 2
  • EC 3.1.13.4 4
  • HCAF1 3
  • CAF1 3

External Ids for CNOT8 Gene

Previous HGNC Symbols for CNOT8 Gene

  • POP2

Previous GeneCards Identifiers for CNOT8 Gene

  • GC05P154331
  • GC05P154221
  • GC05P154266
  • GC05P154218
  • GC05P149380

Summaries for CNOT8 Gene

GeneCards Summary for CNOT8 Gene

CNOT8 (CCR4-NOT Transcription Complex Subunit 8) is a Protein Coding gene. Among its related pathways are TP53 Regulates Transcription of Cell Cycle Genes and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT7.

UniProtKB/Swiss-Prot for CNOT8 Gene

  • Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Gene Wiki entry for CNOT8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT8 Gene

Genomics for CNOT8 Gene

Regulatory Elements for CNOT8 Gene

Enhancers for CNOT8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F154834 1.4 Ensembl ENCODE 34.4 -22.3 -22327 1.9 PKNOX1 ARNT MLX ARID4B FEZF1 ZNF2 YY1 ZNF548 FOS KLF13 CNOT8 SAP30L-AS1 MFAP3 GEMIN5 FAXDC2 MIR378H
GH05F154778 1.2 Ensembl ENCODE 36.2 -74.1 -74053 10.2 PKNOX1 ZFP64 SIN3A FEZF1 ZNF2 GLIS2 FOS ZNF263 TSHZ1 SMARCA4 CNOT8 LARP1 FAXDC2 MIR1303 GC05M154784 GC05P154730
GH05F154764 1.1 Ensembl ENCODE 36.4 -89.3 -89287 7.7 CTCF PKNOX1 SIN3A ZNF384 ZNF121 ZFHX2 ZNF366 POLR2A PRDM10 ZNF600 CNOT8 LARP1 FAXDC2 MIR1303 HAND1 GC05M154784 GC05P154730
GH05F154752 1.2 ENCODE 14.1 -100.1 -100071 9.1 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 LARP1 CNOT8 MIR1303 GEMIN5 SAP30L-AS1 GC05M154784 GC05P154730
GH05F154723 1 Ensembl ENCODE 13.1 -133.4 -133424 1.8 TAL1 ZFP64 ZMYM3 ZIC2 ZNF316 POLR2A FOXK2 ZBTB48 NCOR1 NFE2 LARP1 CNOT8 RN7SL803P RPL21P57
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNOT8 on UCSC Golden Path with GeneCards custom track

Promoters for CNOT8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001294640 1547 4201 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for CNOT8 Gene

Chromosome:
5
Start:
154,857,553 bp from pter
End:
154,876,793 bp from pter
Size:
19,241 bases
Orientation:
Plus strand

Genomic View for CNOT8 Gene

Genes around CNOT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT8 Gene

Proteins for CNOT8 Gene

  • Protein details for CNOT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFF9-CNOT8_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 8
    Protein Accession:
    Q9UFF9
    Secondary Accessions:
    • B0AZS3
    • B2RAR8
    • B7Z8R1
    • D3DQI8
    • O95709
    • Q7Z521
    • Q9H6Y1

    Protein attributes for CNOT8 Gene

    Size:
    292 amino acids
    Molecular mass:
    33540 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. In the complex interacts directly with CNOT1. Interacts with BTG1, BTG2 and TOB1.

    Alternative splice isoforms for CNOT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT8 Gene

Post-translational modifications for CNOT8 Gene

  • Ubiquitination at Lys 206, Lys 242, Lys 254, and Lys 269
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNOT8 Gene

Domains & Families for CNOT8 Gene

Gene Families for CNOT8 Gene

Protein Domains for CNOT8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UFF9

UniProtKB/Swiss-Prot:

CNOT8_HUMAN :
  • Belongs to the CAF1 family.
Family:
  • Belongs to the CAF1 family.
genes like me logo Genes that share domains with CNOT8: view

Function for CNOT8 Gene

Molecular function for CNOT8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function:
Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Enzyme Numbers (IUBMB) for CNOT8 Gene

Gene Ontology (GO) - Molecular Function for CNOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IDA 15769875
GO:0003676 nucleic acid binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS,TAS 10036195
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
genes like me logo Genes that share ontologies with CNOT8: view
genes like me logo Genes that share phenotypes with CNOT8: view

Animal Model Products

miRNA for CNOT8 Gene

miRTarBase miRNAs that target CNOT8

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT8 Gene

Localization for CNOT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNOT8 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for CNOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA,NAS 10036195
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030014 CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT8: view

Pathways & Interactions for CNOT8 Gene

genes like me logo Genes that share pathways with CNOT8: view

Gene Ontology (GO) - Biological Process for CNOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10036195
GO:0006417 regulation of translation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with CNOT8: view

No data available for SIGNOR curated interactions for CNOT8 Gene

Transcripts for CNOT8 Gene

Unigene Clusters for CNOT8 Gene

CCR4-NOT transcription complex, subunit 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - -
SP11: -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - - - - -
SP17: - - - - - - - - - - - -

ExUns: 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: - - -
SP7: - - -
SP8:
SP9: -
SP10: - - -
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17: -

Relevant External Links for CNOT8 Gene

GeneLoc Exon Structure for
CNOT8
ECgene alternative splicing isoforms for
CNOT8

Expression for CNOT8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNOT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNOT8 Gene

This gene is overexpressed in Bone (40.5) and Breast (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNOT8 Gene



Protein tissue co-expression partners for CNOT8 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNOT8 Gene:

CNOT8

SOURCE GeneReport for Unigene cluster for CNOT8 Gene:

Hs.26703
genes like me logo Genes that share expression patterns with CNOT8: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNOT8 Gene

Orthologs for CNOT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT8 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT8 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNOT8 34 35
  • 99.89 (n)
dog
(Canis familiaris)
Mammalia CNOT8 34 35
  • 96 (n)
cow
(Bos Taurus)
Mammalia CNOT8 34 35
  • 94.98 (n)
oppossum
(Monodelphis domestica)
Mammalia CNOT8 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot8 34
  • 89.38 (n)
mouse
(Mus musculus)
Mammalia Cnot8 34 16 35
  • 88.47 (n)
chicken
(Gallus gallus)
Aves CNOT8 34 35
  • 84.08 (n)
lizard
(Anolis carolinensis)
Reptilia CNOT8 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot8 34
  • 78.78 (n)
Str.6603 34
African clawed frog
(Xenopus laevis)
Amphibia cnot8-prov 34
zebrafish
(Danio rerio)
Actinopterygii cnot8 34 35
  • 76.36 (n)
wufe49a05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.467 34
fruit fly
(Drosophila melanogaster)
Insecta CG5684 36
  • 72 (a)
Pop2 35
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ccf-1 35
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POP2 35 37
  • 24 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4584 34
rice
(Oryza sativa)
Liliopsida Os09g0416800 34
  • 53.77 (n)
corn
(Zea mays)
Liliopsida Zm.15431 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
OneToMany
Species where no ortholog for CNOT8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT8 Gene

ENSEMBL:
Gene Tree for CNOT8 (if available)
TreeFam:
Gene Tree for CNOT8 (if available)

Paralogs for CNOT8 Gene

Paralogs for CNOT8 Gene

Pseudogenes.org Pseudogenes for CNOT8 Gene

genes like me logo Genes that share paralogs with CNOT8: view

Variants for CNOT8 Gene

Sequence variations from dbSNP and Humsavar for CNOT8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1063070 -- 154,871,802(+) TTCTT(A/T)CATAT reference, missense
rs111281900 -- 154,864,406(+) TGAGC(C/T)GAGAT intron-variant
rs111328173 -- 154,864,850(+) GCCTG(A/G)GCAAC intron-variant
rs111459058 -- 154,872,832(+) GGTGC(A/G)ATCTC intron-variant
rs111729796 -- 154,858,751(+) CTTCG(C/G)GGGCC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CNOT8 Gene

Variant ID Type Subtype PubMed ID
nsv1073926 CNV deletion 25765185
nsv830521 CNV gain 17160897

Variation tolerance for CNOT8 Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNOT8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT8 Gene

Disorders for CNOT8 Gene

Relevant External Links for CNOT8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNOT8

No disorders were found for CNOT8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT8 Gene

Publications for CNOT8 Gene

  1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert T.K. … Timmers H.T.M. (Nucleic Acids Res. 2000) 2 3 4 22 64
  2. CCR4-NOT deadenylates mRNA associated with complexes in human cells. (PMID: 20065043) Piao X. … Belasco J.G. (Mol. Cell. Biol. 2010) 3 4 22 64
  3. The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. (PMID: 19605561) Aslam A. … Winkler G.S. (Mol. Biol. Cell 2009) 3 4 22 64
  4. Conservation of the deadenylase activity of proteins of the Caf1 family in human. (PMID: 15769875) Bianchin C. … Corbo L. (RNA 2005) 3 4 22 64
  5. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PMID: 11136725) Prevot D. … Corbo L. (J. Biol. Chem. 2001) 3 4 22 64

Products for CNOT8 Gene

Sources for CNOT8 Gene

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