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Aliases for CNOT8 Gene

Aliases for CNOT8 Gene

  • CCR4-NOT Transcription Complex, Subunit 8 2 3
  • CALIF 3 4 6
  • POP2 3 4 6
  • PGK Promoter Directed Over Production 2 3
  • CCR4-Associated Factor 8 3 4
  • CAF1-Like Protein 3 4
  • CALIFp 3 4
  • Caf1b 3 4
  • CAF2 3 4
  • CCR4-NOT Transcription Complex Subunit 8 3
  • EC 3.1.13.4 4
  • HCAF1 3
  • CAF1 3

External Ids for CNOT8 Gene

Previous Symbols for CNOT8 Gene

  • POP2

Summaries for CNOT8 Gene

GeneCards Summary for CNOT8 Gene

CNOT8 (CCR4-NOT Transcription Complex, Subunit 8) is a Protein Coding gene. Diseases associated with CNOT8 include microsporidiosis. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and 3-5-exoribonuclease activity. An important paralog of this gene is CNOT7.

UniProtKB/Swiss-Prot for CNOT8 Gene

  • Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Gene Wiki entry for CNOT8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT8 Gene

Genomics for CNOT8 Gene

Genomic Location for CNOT8 Gene

Start:
154,857,553 bp from pter
End:
154,876,793 bp from pter
Size:
19,241 bases
Orientation:
Plus strand

Genomic View for CNOT8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNOT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT8 Gene

Proteins for CNOT8 Gene

  • Protein details for CNOT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFF9-CNOT8_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 8
    Protein Accession:
    Q9UFF9
    Secondary Accessions:
    • B0AZS3
    • B2RAR8
    • B7Z8R1
    • D3DQI8
    • O95709
    • Q7Z521
    • Q9H6Y1

    Protein attributes for CNOT8 Gene

    Size:
    292 amino acids
    Molecular mass:
    33540 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. In the complex interacts directly with CNOT1. Interacts with BTG1, BTG2 and TOB1.

    Alternative splice isoforms for CNOT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT8 Gene

Proteomics data for CNOT8 Gene at MOPED

Post-translational modifications for CNOT8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys206, Lys242, Lys254, and Lys269

No data available for DME Specific Peptides for CNOT8 Gene

Domains for CNOT8 Gene

Protein Domains for CNOT8 Gene

UniProtKB/Swiss-Prot:

CNOT8_HUMAN
Family:
  • Belongs to the CAF1 family.:
    • Q9UFF9
genes like me logo Genes that share domains with CNOT8: view

No data available for Gene Families for CNOT8 Gene

Function for CNOT8 Gene

Molecular function for CNOT8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function: Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Enzyme Numbers (IUBMB) for CNOT8 Gene

Gene Ontology (GO) - Molecular Function for CNOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IDA 15769875
GO:0003676 nucleic acid binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 10036195
GO:0003723 RNA binding IEA --
GO:0004535 poly(A)-specific ribonuclease activity IDA 15769875
genes like me logo Genes that share ontologies with CNOT8: view

miRNA for CNOT8 Gene

miRTarBase miRNAs that target CNOT8

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNOT8 Gene

Localization for CNOT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT8 Gene COMPARTMENTS Subcellular localization image for CNOT8 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 3
chloroplast 2

Gene Ontology (GO) - Cellular Components for CNOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus NAS 10036195
GO:0005829 cytosol TAS --
GO:0030014 CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT8: view

Pathways for CNOT8 Gene

genes like me logo Genes that share pathways with CNOT8: view

Pathways by source for CNOT8 Gene

1 KEGG pathway for CNOT8 Gene

Gene Ontology (GO) - Biological Process for CNOT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10036195
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with CNOT8: view

Transcripts for CNOT8 Gene

Unigene Clusters for CNOT8 Gene

CCR4-NOT transcription complex, subunit 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - -
SP11: -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - - - - -
SP17: - - - - - - - - - - - -

ExUns: 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: - - -
SP7: - - -
SP8:
SP9: -
SP10: - - -
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17: -

Relevant External Links for CNOT8 Gene

GeneLoc Exon Structure for
CNOT8
ECgene alternative splicing isoforms for
CNOT8

Expression for CNOT8 Gene

mRNA expression in normal human tissues for CNOT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT8 Gene

SOURCE GeneReport for Unigene cluster for CNOT8 Gene Hs.26703

genes like me logo Genes that share expressions with CNOT8: view

Orthologs for CNOT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT8 36
  • 99.89 (n)
  • 100 (a)
CNOT8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT8 36
  • 94.98 (n)
  • 100 (a)
CNOT8 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT8 36
  • 96 (n)
  • 100 (a)
CNOT8 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot8 36
  • 88.47 (n)
  • 99.32 (a)
Cnot8 16
Cnot8 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT8 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT8 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot8 36
  • 89.38 (n)
  • 99.32 (a)
chicken
(Gallus gallus)
Aves CNOT8 36
  • 84.08 (n)
  • 97.94 (a)
CNOT8 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNOT8 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cnot8-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot8 36
  • 78.78 (n)
  • 92.39 (a)
Str.6603 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.467 36
zebrafish
(Danio rerio)
Actinopterygii cnot8 36
  • 76.36 (n)
  • 85.11 (a)
cnot8 37
  • 85 (a)
OneToOne
wufe49a05 36
fruit fly
(Drosophila melanogaster)
Insecta Pop2 37
  • 50 (a)
OneToMany
CG5684 38
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea ccf-1 37
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POP2 37
  • 24 (a)
OneToMany
POP2 39
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4584 36
corn
(Zea mays)
Liliopsida Zm.15431 36
rice
(Oryza sativa)
Liliopsida Os09g0416800 36
  • 53.77 (n)
  • 53.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 66 (a)
OneToMany
Species with no ortholog for CNOT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT8 Gene

ENSEMBL:
Gene Tree for CNOT8 (if available)
TreeFam:
Gene Tree for CNOT8 (if available)

Paralogs for CNOT8 Gene

Paralogs for CNOT8 Gene

Pseudogenes.org Pseudogenes for CNOT8 Gene

genes like me logo Genes that share paralogs with CNOT8: view

Variants for CNOT8 Gene

Sequence variations from dbSNP and Humsavar for CNOT8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs12300 -- 154,876,615(-) TTTTA(C/T)TTCCA utr-variant-3-prime
rs40584 -- 154,860,363(-) ATTAC(A/G)CCACT intron-variant
rs816720 -- 154,867,336(+) AAGGT(A/G)TTGGA intron-variant, upstream-variant-2KB
rs816721 -- 154,868,268(+) CTTTT(C/T)TTTTT intron-variant
rs816722 -- 154,868,299(+) TGTCT(C/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT8 Gene

Variant ID Type Subtype PubMed ID
nsv830521 CNV Gain 17160897

Relevant External Links for CNOT8 Gene

HapMap Linkage Disequilibrium report
CNOT8

Disorders for CNOT8 Gene

(1) MalaCards Diseases for CNOT8 Gene

Search for CNOT8 Gene in MalaCards »

(3) University of Copenhagen DISEASES for CNOT8 Gene

genes like me logo Genes that share disorders with CNOT8: view

No data available for UniProtKB/Swiss-Prot for CNOT8 Gene

Publications for CNOT8 Gene

  1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert T.K. … Timmers H.T.M. (Nucleic Acids Res. 2000) 2 3 4 23
  2. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PMID: 11136725) Prevot D. … Corbo L. (J. Biol. Chem. 2001) 3 4 23
  3. Conservation of the deadenylase activity of proteins of the Caf1 family in human. (PMID: 15769875) Bianchin C. … Corbo L. (RNA 2005) 3 4 23
  4. The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. (PMID: 19605561) Aslam A. … Winkler G.S. (Mol. Biol. Cell 2009) 3 4 23
  5. CCR4-NOT deadenylates mRNA associated with complexes in human cells. (PMID: 20065043) Piao X. … Belasco J.G. (Mol. Cell. Biol. 2010) 3 4 23

Products for CNOT8 Gene

  • Addgene plasmids for CNOT8

Sources for CNOT8 Gene

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