Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CNOT7 Gene

protein-coding   GIFtS: 60
GCID: GC08M017086

CCR4-NOT Transcription Complex, Subunit 7


(Previous symbol: CAF1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CCR4-NOT Transcription Complex, Subunit 71 2     CCR4-Associated Factor 12 3
CAF11 2 3 5     Carbon Catabolite Repressor Protein (CCR4)-Associative Factor 12
BTG1 Binding Factor 11 2     CCR4-NOT Transcription Complex Subunit 72
CAF-12 3     hCAF-12
Caf1a2 3     EC 3.1.13.43
BTG1-Binding Factor 12 3     

External Ids:    HGNC: 141011   Entrez Gene: 298832   Ensembl: ENSG000001987917   OMIM: 6049135   UniProtKB: Q9UIV13   

Export aliases for CNOT7 gene to outside databases

Previous GC identifers: GC08M016980 GC08M017166 GC08M017097 GC08M017131 GC08M015631


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CNOT7 Gene:
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which
negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the
anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation
associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this
gene results in two transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for CNOT7 Gene:
CNOT7 (CCR4-NOT transcription complex, subunit 7) is a protein-coding gene. Diseases associated with CNOT7 include male infertility, and infertility. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and signal transducer activity. An important paralog of this gene is CNOT8.

UniProtKB/Swiss-Prot: CNOT7_HUMAN, Q9UIV1
Function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be
partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major
cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation,
miRNA-mediated repression, translational repression during translational initiation and general transcription
regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during
translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression.
Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative
activity

Gene Wiki entry for CNOT7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNOT7 gene promoter:
         HFH-3   RP58   Pax-5   Cdc5   LCR-F1   FOXI1   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNOT7 promoter sequence
   Search Chromatin IP Primers for CNOT7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNOT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21.3   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22-p21.3

CNOT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M017086:  view genomic region     (about GC identifiers)

Start:
17,086,737 bp from pter      End:
17,104,387 bp from pter
Size:
17,651 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CNOT7_HUMAN, Q9UIV1 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 7  
Size: 285 amino acids; 32745 Da
Cofactor: Binds 2 divalent metal cations per subunit with RNAase activity being higher in presence of Mn(2+) than
of Mg(2+) or Co(2+)
Subunit: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of
probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L,
and CNOT7 or CNOT8. In the complex, interacts directly with CNOT1. Interacts with AGO2, TOB1, BTG1, BTG2 and
NANOS2
Sequence caution: Sequence=AAF01500.1; Type=Frameshift; Positions=4;
2 PDB 3D structures from and Proteopedia for CNOT7:
2D5R (3D)        4GMJ (3D)    
Secondary accessions: A8MZM5 B3KMP1 B3KN35 D3DSP6 G3V108 Q7Z530
Alternative splicing: 2 isoforms:  Q9UIV1-1   Q9UIV1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNOT7: NX_Q9UIV1

Explore proteomics data for CNOT7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys33, Lys206, Lys240
  • Modification sites at PhosphoSitePlus

  • See CNOT7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_037486.2  NP_473367.2  

    ENSEMBL proteins: 
     ENSP00000355279   ENSP00000430263   ENSP00000429093   ENSP00000429632   ENSP00000428147  
     ENSP00000430160   ENSP00000428783   ENSP00000429079  
    Reactome Protein details: Q9UIV1

    CNOT7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CNOT7
    OriGene Protein Over-expression Lysate for CNOT7
    OriGene MassSpec for CNOT7
    OriGene Custom Protein Services for CNOT7
    GenScript Custom Purified and Recombinant Proteins Services for CNOT7
    Novus Biologicals CNOT7 Proteins
    Novus Biologicals CNOT7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CNOT7
    Cloud-Clone Corp. Proteins for CNOT7

    CNOT7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CNOT7
    OriGene Custom Antibody Services for CNOT7
    Novus Biologicals CNOT7 Antibodies
    Abcam antibodies for CNOT7
    Cloud-Clone Corp. Antibodies for CNOT7
    ThermoFisher Antibodies for CNOT7
    LSBio Antibodies in human, mouse, rat for CNOT7

    CNOT7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CNOT7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CNOT7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNOT7
    Cloud-Clone Corp. CLIAs for CNOT7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR006941 RNase_CAF1
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UIV1

    ProtoNet protein and cluster: Q9UIV1

    1 Blocks protein domain: IPB006941 CAF1 family ribonuclease

    UniProtKB/Swiss-Prot: CNOT7_HUMAN, Q9UIV1
    Similarity: Belongs to the CAF1 family


    CNOT7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNOT7_HUMAN, Q9UIV1
    Function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be
    partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major
    cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation,
    miRNA-mediated repression, translational repression during translational initiation and general transcription
    regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during
    translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression.
    Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative
    activity
    Catalytic activity: Exonucleolytic cleavage of poly(A) to 5'-AMP

         Enzyme Number (IUBMB): EC 3.1.13.41

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00001753'-5'-exoribonuclease activity IDA15769875
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9820826
    GO:0003723RNA binding IEA--
    GO:0004532exoribonuclease activity IDA19276069
         
    CNOT7 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cnot7):
     cellular  endocrine/exocrine gland  reproductive system 

    CNOT7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cnot7tm1Jpr for CNOT7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNOT7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNOT7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNOT7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNOT7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CNOT7:
    hsa-mir-106b-5p (MIRT044358), hsa-mir-16-5p (MIRT031760)

    Block miRNA regulation of human, mouse, rat CNOT7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNOT7 (see all 69):
    hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-1244 hsa-miR-93 hsa-miR-3613-3p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCNOT7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CNOT7
    Predesigned siRNA for gene silencing in human, mouse, rat CNOT7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CNOT7

    Clone
    Products:
         
    OriGene clones in human, mouse for CNOT7 (see all 13)
    OriGene ORF clones in mouse, rat for CNOT7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CNOT7 (NM_013354)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CNOT7
    Browse ESI BIO Cell Lines and PureStem Progenitors for CNOT7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CNOT7_HUMAN, Q9UIV1: Nucleus. Cytoplasm, P-body (By similarity). Note=NANOS2 promotes its localization to P-body
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005634nucleus IDA9820826
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0030014CCR4-NOT complex NAS9820826

    CNOT7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CNOT7 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40
    3Cyclins and Cell Cycle Regulation
    Cell Cycle Control by BTG Proteins0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CNOT7
        Cell Cycle Control by BTG Proteins

    1 Reactome Pathway for CNOT7
        Deadenylation of mRNA


    1 Kegg Pathway  (Kegg details for CNOT7):
        RNA degradation


    CNOT7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNOT7
    Interactions:

        GeneGlobe Interaction Network for CNOT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CNOT7 (Q9UIV11, 2, 3 ENSP000003552794) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOB1P506161, 2, 3, ENSP000002689574EBI-2105113,EBI-723281 MINT-8173967 MINT-8176376 MINT-8176406 I2D: score=3 STRING: ENSP00000268957
    BTG1P623241, 2, 3, ENSP000002560154EBI-2105113,EBI-742279 MINT-8249663 I2D: score=4 STRING: ENSP00000256015
    CPEB3Q8NE352, ENSP000002659974MINT-8173967 MINT-8176376 MINT-8176406 STRING: ENSP00000265997
    BTG2P785431, 3, ENSP000002905514EBI-2105113,EBI-1047576 I2D: score=3 STRING: ENSP00000290551
    CNOT6Q9ULM61, 3, ENSP000002619514EBI-2105113,EBI-2104530 I2D: score=1 STRING: ENSP00000261951
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA IEA--
    GO:0005975carbohydrate metabolic process TAS9820826
    GO:0006351transcription, DNA-templated IEA--

    CNOT7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNOT7

    1 Novoseek inferred chemical compound relationship for CNOT7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbon 11.2 3 11267995 (1), 9820826 (1)



    CNOT7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CNOT7 gene (2 alternative transcripts): 
    NM_013354.5  NM_054026.2  

    Unigene Cluster for CNOT7:

    CCR4-NOT transcription complex, subunit 7
    Hs.645009  [show with all ESTs]
    Unigene Representative Sequence: BC060852
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361272(uc003wxf.1 uc003wxg.1) ENST00000518541 ENST00000523917(uc003wxh.1)
    ENST00000519954 ENST00000519918 ENST00000522062 ENST00000524358 ENST00000519998(uc003wxi.1)
    ENST00000518021 ENST00000520178 ENST00000518885 ENST00000523649
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CNOT7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNOT7 (see all 69):
    hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-1244 hsa-miR-93 hsa-miR-3613-3p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCNOT7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CNOT7
    Predesigned siRNA for gene silencing in human, mouse, rat CNOT7
    Clone
    Products:
         
    OriGene clones in human, mouse for CNOT7 (see all 13)
    OriGene ORF clones in mouse, rat for CNOT7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CNOT7 (NM_013354)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CNOT7
    OriGene qSTAR qPCR primer pairs in human, mouse for CNOT7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNOT7
      QuantiTect SYBR Green Assays in human, mouse, rat CNOT7
      QuantiFast Probe-based Assays in human, mouse, rat CNOT7

    Additional mRNA sequence: 

    AF086915.1 AK001209.1 AK021808.1 AK023466.1 AK023561.1 AK225893.1 AL833642.1 BC007315.2 
    BC060852.1 BC070187.1 BT006685.1 L46722.1 

    Selected DOTS entries (see all 31):

    DT.92447025  DT.95237293  DT.92447026  DT.92409785  DT.92410293  DT.91874486  DT.97792166  DT.100828234 
    DT.121478489  DT.121478452  DT.100828237  DT.121478459  DT.100828232  DT.102830616  DT.91993025  DT.75157876 
    DT.100828231  DT.100828238  DT.100828239  DT.121235536  DT.121314489  DT.95148881  DT.100745207  DT.100828236 

    Selected AceView cDNA sequences (see all 388):

    AI197894 BC070187 AA165430 BQ637756 R27369 BM803282 AI336479 AA286882 
    BM474712 CB140191 AA832313 BQ231006 BQ686544 AA256677 AU123461 T93986 
    AI140546 AU159570 BX485616 BX116322 BE408456 AA133185 AA133372 AA187926 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNOT7 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b ^ 12a · 12b ·
    SP1:                                                                                                                                                            
    SP2:                                -     -     -     -                       -                                                                                 
    SP3:                                            -     -                       -     -     -     -                                                               
    SP4:              -     -     -     -     -     -     -                       -     -     -     -                                                               
    SP5:              -     -     -     -     -     -     -                       -                                                                                 

    ExUns: 12c ^ 13a · 13b ^ 14
    SP1:              -         
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CNOT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CNOT7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATTACAGT
    CNOT7 Expression
    About this image


    CNOT7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    CNOT7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNOT7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645009
        Custom PCR Arrays for CNOT7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CNOT7
    OriGene qSTAR qPCR primer pairs in human, mouse for CNOT7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNOT7
    QuantiTect SYBR Green Assays in human, mouse, rat CNOT7
    QuantiFast Probe-based Assays in human, mouse, rat CNOT7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNOT7 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnot71 , 5 CCR4-NOT transcription complex, subunit 71, 5 93.1(n)1
    99.65(a)1
      8 (23.89 cM)5
    189831  NM_011135.51  NP_035265.11 
     404925405 
    chicken
    (Gallus gallus)
    Aves CNOT71 CCR4-NOT transcription complex, subunit 7 88.3(n)
    100(a)
      422733  NM_001006454.1  NP_001006454.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNOT76
    CCR4-NOT transcription complex, subunit 7
    100(a)
    1 ↔ 1
    5(108213796-108228304)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cnot71 CCR4-NOT transcription complex, subunit 7 82.57(n)
    96.84(a)
      100124970  NM_001102905.1  NP_001096375.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cnot71 CCR4-NOT transcription complex, subunit 7 80.87(n)
    95.77(a)
      768119  NM_001077255.1  NP_001070723.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56843
    Pop21
    general RNA polymerase II
    transcription factor3
    Pop21
    75(a)3
    66.03(n)1
    75.38(a)1
      68F13
    393661  NM_168485.21  NP_729776.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ccf-11 ccf-1 54.99(n)
    49.81(a)
      176625  NM_067152.6  NP_499553.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POP26
    RNase of the DEDD superfamily, subunit of the Ccr4...
    24(a)
    1 → many
    XIV(719346-720647) YNR052C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G109601 AT5G10960 55.39(n)
    52.63(a)
      830963  NM_121134.3  NP_196657.1 
    rice
    (Oryza sativa)
    Liliopsida AK099984.12   -- 71.58(n)    AK099984.1 


    ENSEMBL Gene Tree for CNOT7 (if available)
    TreeFam Gene Tree for CNOT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CNOT7 gene
    CNOT82  
    1 SIMAP similar gene for CNOT7 using alignment to 7 protein entries:     CNOT7_HUMAN (see all proteins):
    CNOT8

    CNOT7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CNOT7
    PGOHUM00000244864 PGOHUM00000241370


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CNOT7 (see all 389)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894420981,2
    --17086301(+) GCATTG/TATTTC 1 -- ds50010--------
    rs1806780391,2
    --17086330(+) TTTAAA/GTATTA 1 -- ds50010--------
    rs1427153331,2
    --17086485(+) ATATCC/GTTCGG 1 -- ds50010--------
    rs21576331,2
    C,F,H--17086512(+) GAAAGG/AAGAAA 1 -- ds50018Minor allele frequency- A:0.02EA NA NS 594
    rs624973511,2
    C,F--17086601(+) CAGACT/GGATTT 1 -- ds50012Minor allele frequency- G:0.18NA 122
    rs749482521,2
    C,F--17086642(+) TTAATG/AAAGGA 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs735556501,2
    C,F--17086738(+) AACATT/CTATAA 1 -- ds50012Minor allele frequency- C:0.09WA 120
    rs10430931,2
    C,F,H--17086756(-) AGGCTT/GCAAAA 1 -- ut3117Minor allele frequency- G:0.05NA NS EA 1760
    rs1442650971,2
    C--17086811(+) AAATA-/ATGTTTT 1 -- ut310--------
    rs1836441041,2
    --17086909(+) GAGATG/TTGCTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CNOT7 (17086737 - 17104387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CNOT7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831244CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNOT7
    DNA2.0 Custom Variant and Variant Library Synthesis for CNOT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604913    OMIM disorders: --

    7 diseases for CNOT7:    
    About MalaCards
    male infertility    infertility    colorectal cancer    malaria
    hypoxia    breast cancer    melanoma


    CNOT7 for disorders           About GeneDecksing


    Export disorders for CNOT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CNOT7 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with CNOT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hCAF1, a new regulator of PRMT1-dependent arginine methylation. (PubMed id 17264152)1, 3, 9 Robin-Lespinasse Y....Le Romancer M. (J. Cell. Sci. 2007)
    2. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. (PubMed id 9820826)1, 2, 9 Bogdan J.A.... Dicker I.B. (Biochem. J. 1998)
    3. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4- not complex. (PubMed id 23236473)1, 2 Doidge R.... Winkler G.S. (PLoS ONE 2012)
    4. Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)1, 2 Lau N.C.... Timmers H.T. (Biochem. J. 2009)
    5. Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. (PubMed id 19276069)1, 2 Horiuchi M.... Inagaki F. (J. Biol. Chem. 2009)
    6. The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. (PubMed id 19605561)1, 2 Aslam A.... Winkler G.S. (Mol. Biol. Cell 2009)
    7. Conservation of the deadenylase activity of proteins of the Caf1 family in human. (PubMed id 15769875)1, 2 Bianchin C.... Corbo L. (RNA 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 3 Albert T.K....Timmers H.T.M. (Nucleic Acids Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29883 HGNC: 14101 AceView: CNOT7 Ensembl:ENSG00000198791 euGenes: HUgn29883
    ECgene: CNOT7 Kegg: 29883 H-InvDB: CNOT7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CNOT7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CNOT7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CNOT7 gene:
    Search GeneIP for patents involving CNOT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CNOT7   OriGene RNAi products in human, mouse, rat for CNOT7  
     OriGene qPCR primer pairs and template standards for CNOT7   OriGene Protein Over-expression Lysate for CNOT7  
     OriGene MassSpec something-or-other for CNOT7   OriGene clones in human, mouse for CNOT7  
     OriGene qSTAR qPCR primer pairs in human, mouse for CNOT7   OriGene Purified Protein for CNOT7  
     OriGene ORF clones in mouse, rat for CNOT7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CNOT7   OriGene Custom Protein Services for CNOT7  

     
     
     Block miRNA regulation of human, mouse, rat CNOT7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CNOT7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNOT7 Predesigned siRNA for gene silencing in human, mouse, rat CNOT7
     QuantiFast Probe-based Assays in human, mouse, rat CNOT7 QuantiTect SYBR Green Assays in human, mouse, rat CNOT7
     Custom PCR Arrays for CNOT7 Search Chromatin IP Primers for CNOT7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNOT7  GeneGlobe Interaction Network for CNOT7
     Regulatory tfbs in CNOT7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CNOT7 GenScript cDNA clones with any tag delivered in your preferred vector for CNOT7
     GenScript Custom Assay Services for CNOT7 GenScript Custom overexpressing Cell Line Services for CNOT7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CNOT7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CNOT7 antibodies
     CNOT7 proteins
     CNOT7 lysates
     Antibodies for CNOT7
     See all of Abcam's Antibodies, Kits and Proteins for CNOT7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CNOT7
     Proteins for CNOT7
     Antibodies for CNOT7
     ELISAs for CNOT7
     CLIAs for CNOT7



     Browse ESI BIO Cell Lines and PureStem Progenitors for CNOT7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT7
     SwitchGear 3'UTR luciferase reporter plasmids for CNOT7
     SwitchGear Promoter luciferase reporter plasmids for CNOT7
     ThermoFisher Antibodies for CNOT7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNOT7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNOT7
     LSBio Antibodies in human, mouse, rat for CNOT7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CNOT7 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4