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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CNOT7 Gene

protein-coding GIFtS: 56
GCID: GC08M017086

CCR4-NOT transcription complex, subunit 7

(Previous symbol: CAF1)

Explore 2 diseases affiliated with
CNOT7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CCR4-NOT Transcription Complex, Subunit 7¹ ²		BTG1 Binding Factor 1²
CAF1¹ ² ³ ⁵		Carbon Catabolite Repressor Protein (CCR4)-Associative Factor 1²
CAF-1² ³		CCR4-NOT Transcription Complex Subunit 7²
BTG1-Binding Factor 1² ³		HCAF-1¹
CCR4-Associated Factor 1² ³

External Ids:	HGNC: 14101¹	Entrez Gene: 29883²	Ensembl: ENSG00000198791⁷	OMIM: 604913⁵	UniProtKB: Q9UIV1³

Export aliases for CNOT7 gene to outside databases

Previous GC identifers: GC08M016980 GC08M017166 GC08M017097 GC08M017131 GC08M015631

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNOT7:

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which

negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the

anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation

associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene

results in two transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CNOT7_HUMAN, Q9UIV1

Function: Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4

complex involved in the control of gene expression (By similarity)

Gene Wiki entry for CNOT7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CNOT7 gene promoter:
HFH-3 RP58 Pax-5 Cdc5 LCR-F1 FOXI1 POU2F1 POU2F1b POU2F1a POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNOT7 promoter sequence

Search SABiosciences Chromatin IP Primers for CNOT7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21.3 Ensembl cytogenetic band: 8p22 HGNC cytogenetic band: 8p22-p21.3

CNOT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT7 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M017086: view genomic region (about GC identifiers)

Start:	17,086,737 bp from pter	End:	17,104,387 bp from pter
Size:	17,651 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNOT7_HUMAN, Q9UIV1 (See protein sequence)

Recommended Name: CCR4-NOT transcription complex subunit 7

Size: 285 amino acids; 32745 Da

Subunit: Interacts with TOB1. Interacts with NANOS2 (By similarity)

Subcellular location: Nucleus. Cytoplasm, P-body (By similarity). Note=NANOS2 promotes its localization to P-body (By

similarity)

Sequence caution: Sequence=AAF01500.1; Type=Frameshift; Positions=4;

2 PDB 3D structures from and Proteopedia for CNOT7:

2D5R (3D)

4GMJ (3D)

Secondary accessions: A8MZM5 B3KMP1 B3KN35 D3DSP6 G3V108 Q7Z530

Alternative splicing: 2 isoforms: Q9UIV1-1 Q9UIV1-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNOT7: NX_Q9UIV1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UIV1

CNOT7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_037486.2 NP_473367.2

ENSEMBL proteins:

ENSP00000355279 ENSP00000430263 ENSP00000429093 ENSP00000429632 ENSP00000428147

ENSP00000430160 ENSP00000428783 ENSP00000429079

Reactome Protein details: Q9UIV1
Human Recombinant Protein Products for CNOT7:

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	Novus Biologicals CNOT7 Proteins Novus Biologicals CNOT7 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CNOT7
	Uscn Proteins for CNOT7

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000932	cytoplasmic mRNA processing body	ISS	--
GO:0005634	nucleus	IDA	9820826
GO:0005829	cytosol	TAS	--
GO:0030014	CCR4-NOT complex	NAS	9820826

CNOT7 for ontologies About GeneDecksing

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Assay Products for CNOT7:

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	Uscn ELISAs and CLIAs for CNOT7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CNOT7 for domains About GeneDecksing

2 InterPro domains/families:

IPR006941 RNase_CAF1

IPR012337 RNaseH-like_dom

Graphical View of Domain Structure for InterPro Entry Q9UIV1

ProtoNet protein and cluster: Q9UIV1

1 Blocks protein family: IPB006941 CAF1 family ribonuclease

UniProtKB/Swiss-Prot: CNOT7_HUMAN, Q9UIV1

Similarity: Belongs to the CAF1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CNOT7_HUMAN, Q9UIV1

Function: Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4

complex involved in the control of gene expression (By similarity)

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	9820826
GO:0004535	poly(A)-specific ribonuclease activity	IEA	--
GO:0004871	signal transducer activity	TAS	9820826
GO:0005515	protein binding	IPI	9820826

CNOT7 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cnot7):

cellular

endocrine/exocrine gland

reproductive system

CNOT7 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cnot7^tm1Jpr for CNOT7

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CNOT7

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		hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-1244 hsa-miR-93 hsa-miR-3613-3p hsa-miR-155*

		SwitchGear 3'UTR luciferase reporter plasmid: CNOT7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Deadenylation-dependent mRNA decay

	Deadenylation-dependent mRNA decay	1.00			Deadenylation of mRNA	0.47
	RNA degradation	0.50

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Generic Transcription Pathway

Gene Expression

0.46

Cyclins and Cell Cycle Regulation

Cell Cycle Control by BTG Proteins

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CNOT7

Cell Cycle Control by BTG Proteins

5 Reactome Pathways for CNOT7

	Deadenylation of mRNA
	Deadenylation-dependent mRNA decay
	Metabolism of RNA
	Metabolism of mRNA
	Gene Expression

1 Kegg Pathway (Kegg details for CNOT7):

RNA degradation

CNOT7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CNOT7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/52 Interacting proteins for CNOT7 (Q9UIV1^{2, 3} ENSP00000355279⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TOB1	P50616²^,³, ENSP00000268957⁴	MINT-8173967 MINT-8176376 MINT-8176406 I2D: score=3 STRING: ENSP00000268957
CPEB3	Q8NE35², ENSP00000265997⁴	MINT-8173967 MINT-8176376 MINT-8176406 STRING: ENSP00000265997
BTG1	P62324²^,³, ENSP00000256015⁴	MINT-8249663 I2D: score=4 STRING: ENSP00000256015
CDK2	P24941³, ENSP00000266970⁴	I2D: score=2 STRING: ENSP00000266970
CDK4	P11802³, ENSP00000257904⁴	I2D: score=2 STRING: ENSP00000257904

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	TAS	--
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	TAS	--
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	IEA	--
GO:0005975	carbohydrate metabolic process	TAS	9820826
GO:0006351	transcription, DNA-dependent	IEA	--

CNOT7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CNOT7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CNOT7
1 Novoseek chemical compound relationship for CNOT7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carbon	11.2	3	11267995 (1), 9820826 (1)

Search CenterWatch for drugs/clinical trials and news about CNOT7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CNOT7 gene (2 alternative transcripts):

NM_013354.5 NM_054026.2

Unigene Cluster for CNOT7:

CCR4-NOT transcription complex, subunit 7

Hs.645009 [show with all ESTs]

Unigene Representative Sequence: BC060852

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361272(uc003wxf.1 uc003wxg.1) ENST00000518541 ENST00000523917(uc003wxh.1)

ENST00000519954 ENST00000519918 ENST00000522062 ENST00000524358 ENST00000519998(uc003wxi.1)

ENST00000518021 ENST00000520178 ENST00000518885 ENST00000523649

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		8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT7 (see all 69):
		hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-1244 hsa-miR-93 hsa-miR-3613-3p hsa-miR-155*

		SwitchGear 3'UTR luciferase reporter plasmid: CNOT7 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT7

Additional cDNA sequence:

AF086915.1 AK001209.1 AK021808.1 AK023466.1 AK023561.1 AK225893.1 AL833642.1 BC007315.2

BC060852.1 BC070187.1 BT006685.1 L46722.1

24/31 DOTS entries (see all 31):

DT.92447025 DT.95237293 DT.92447026 DT.92409785 DT.92410293 DT.91874486 DT.97792166 DT.100828234

DT.121478489 DT.121478452 DT.100828237 DT.121478459 DT.100828232 DT.102830616 DT.91993025 DT.75157876

DT.100828231 DT.100828238 DT.100828239 DT.121235536 DT.121314489 DT.95148881 DT.100745207 DT.100828236

24/388 AceView cDNA sequences (see all 388):

AA256677 AI336479 T93986 AA419602 BC070187 AI393174 BC060852 BE408456

BU165351 AA921721 AA173958 AW149045 R27369 AA165430 BG289185 CB140191

AK021808 BX116322 AI375215 BQ924072 AA832313 BC007315 AA133185 BU740104

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT7 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	·	9d	·	9e	^	10	^	11a	·	11b	^	12a	·	12b	·
SP1:
SP2:											-		-		-		-								-
SP3:															-		-								-		-		-		-
SP4:					-		-		-		-		-		-		-								-		-		-		-
SP5:					-		-		-		-		-		-		-								-

ExUns:	12c	^	13a	·	13b	^	14
SP1:					-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CNOT7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CNOT7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATTACAGT

About this image
See CNOT7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNOT7

SOURCE GeneReport for Unigene cluster: Hs.645009
SABiosciences Custom PCR Arrays for CNOT7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNOT7 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT7 gene from 7/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CNOT7¹	CCR4-NOT transcription complex, subunit 7	88.3(n) 100(a)		422733 NM_001006454.1 NP_001006454.1
lizard (Anolis carolinensis)	Reptilia	CNOT7⁶	--	100(a)	1 ↔ 1	5(108215919-108228221)
zebrafish (Danio rerio)	Actinopterygii	cnot7¹	CCR4-NOT transcription complex, subunit 7	80.87(n) 95.77(a)		768119 NM_001077255.1 NP_001070723.1
fruit fly (Drosophila melanogaster)	Insecta	CG5684³ Pop2¹	general RNA polymerase II transcription factor³ CG5684-PA¹	75(a)³ 66.03(n)¹ 75.38(a)¹		68F1³ 39366¹ NM_140281.2¹ NP_648538.1¹
worm (Caenorhabditis elegans)	Secernentea	ccf-1¹	Protein CCF-1	54.86(n) 49.42(a)		176625 NM_067152.5 NP_499553.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G80780¹	putative CCR4-associated factor 1-6	57.66(n) 59.07(a)		844417 NM_106726.4 NP_178193.1
rice (Oryza sativa)	Liliopsida	AK099984.1²	--	71.58(n)		AK099984.1

ENSEMBL Gene Tree for CNOT7 (if available)
TreeFam Gene Tree for CNOT7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CNOT7 gene

CNOT8²

1 SIMAP similar gene for CNOT7 using alignment to 7 protein entries: CNOT7_HUMAN (see all proteins):

CNOT8

CNOT7 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for CNOT7
PGOHUM00000244864 PGOHUM00000241370

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189442098^1,2		--	17086301(+)	`GCATTG/TATTTC`	1	--	ds500¹		0	--	--	--	--
rs180678039^1,2		--	17086330(+)	`TTTAAA/GTATTA`	1	--	ds500¹		0	--	--	--	--
rs142715333^1,2		--	17086485(+)	`ATATCC/GTTCGG`	1	--	ds500¹		0	--	--	--	--
rs2157633^1,2	C,F,H	--	17086512(+)	`GAAAGG/AAGAAA`	1	--	ds500¹		8		EA NA NS	594
rs62497351^1,2	C	--	17086601(+)	`CAGACT/GGATTT`	1	--	ds500¹		2		NA	122
rs74948252^1,2	F	--	17086642(+)	`TTAATG/AAAGGA`	1	--	ds500¹		1		EA	120
rs73555650^1,2	C	--	17086738(+)	`AACATT/CTATAA`	1	--	ds500¹		2		WA	120
rs1043093^1,2	C,F,H	--	17086756(-)	`AGGCTT/GCAAAA`	1	--	ut3¹		17		NA NS EA	1760
rs144265097^1,2	C	--	17086811(+)	`AAATA-/ATGTTTT`	1	--	ut3¹		0	--	--	--	--
rs183644104^1,2		--	17086909(+)	`GAGATG/TTGCTA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CNOT7 (17086737 - 17104387 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CNOT7: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CNOT7 for disorders           About GeneDecksing

OMIM gene information: 604913    OMIM disorders: --

2 diseases for CNOT7:    About MalaCards

colorectal cancer breast cancer

1 disease from the University of Copenhagen DISEASES database for CNOT7:

Male infertility

Export disorders for CNOT7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CNOT7 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with CNOT7)

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world of online information

hCAF1, a new regulator of PRMT1-dependent arginine methylation. (PubMed id 17264152)^{1, 3, 9} Robin-Lespinasse Y....Le Romancer M. (2007)
Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. (PubMed id 9820826)^{1, 2, 9} Bogdan J.A.... Dicker I.B. (1998)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)^{1, 3} Albert T.K....Timmers H.T. (2000)
Sequence identification of 2,375 human brain genes. (PubMed id 1538749)^{1, 3} Adams M.D.... Venter J.C. (1992)
Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer. (PubMed id 12845644)^{1, 9} Flanagan J....Chenevix-Trench G. (2003)
Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PubMed id 11429045)^{1, 9} Yoshida Y....Yamamoto T. (2001)
Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. (PubMed id 10602502)^{1, 9} Ikematsu N.... Yamamoto T. (1999)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 29883	HGNC: 14101	AceView: CNOT7	Ensembl:ENSG00000198791	euGenes: HUgn29883
ECgene: CNOT7	Kegg: 29883	H-InvDB: CNOT7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CNOT7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CNOT7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CNOT7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CNOT7 gene:
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GeneCards and IP:
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CCR4-NOT transcription complex, subunit 7

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CNOT7 Gene

CCR4-NOT transcription complex, subunit 7

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