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Aliases for CNOT7 Gene

Aliases for CNOT7 Gene

  • CCR4-NOT Transcription Complex, Subunit 7 2 3
  • CAF1 3 4 6
  • CCR4-Associated Factor 1 3 4
  • BTG1 Binding Factor 1 2 3
  • BTG1-Binding Factor 1 3 4
  • CAF-1 3 4
  • Caf1a 3 4
  • Carbon Catabolite Repressor Protein (CCR4)-Associative Factor 1 3
  • CCR4-NOT Transcription Complex Subunit 7 3
  • EC 3.1.13.4 4
  • HCAF-1 3

External Ids for CNOT7 Gene

Previous HGNC Symbols for CNOT7 Gene

  • CAF1

Previous GeneCards Identifiers for CNOT7 Gene

  • GC08M016980
  • GC08M017166
  • GC08M017097
  • GC08M017131
  • GC08M017086
  • GC08M015631

Summaries for CNOT7 Gene

Entrez Gene Summary for CNOT7 Gene

  • The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

GeneCards Summary for CNOT7 Gene

CNOT7 (CCR4-NOT Transcription Complex, Subunit 7) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and signal transducer activity. An important paralog of this gene is CNOT8.

UniProtKB/Swiss-Prot for CNOT7 Gene

  • Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Gene Wiki entry for CNOT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT7 Gene

Genomics for CNOT7 Gene

Regulatory Elements for CNOT7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNOT7 Gene

Start:
17,224,964 bp from pter
End:
17,246,878 bp from pter
Size:
21,915 bases
Orientation:
Minus strand

Genomic View for CNOT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNOT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT7 Gene

Proteins for CNOT7 Gene

  • Protein details for CNOT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIV1-CNOT7_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 7
    Protein Accession:
    Q9UIV1
    Secondary Accessions:
    • A8MZM5
    • B3KMP1
    • B3KN35
    • D3DSP6
    • G3V108
    • Q7Z530

    Protein attributes for CNOT7 Gene

    Size:
    285 amino acids
    Molecular mass:
    32745 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Binds 2 divalent metal cations per subunit with RNAase activity being higher in presence of Mn(2+) than of Mg(2+) or Co(2+).;
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. In the complex, interacts directly with CNOT1. Interacts with AGO2, TOB1, BTG1, BTG2 and NANOS2.
    SequenceCaution:
    • Sequence=AAF01500.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT7 Gene

    Alternative splice isoforms for CNOT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT7 Gene

Proteomics data for CNOT7 Gene at MOPED

Post-translational modifications for CNOT7 Gene

  • Ubiquitination at Lys33, Lys206, and Lys240
  • Modification sites at PhosphoSitePlus

Other Protein References for CNOT7 Gene

No data available for DME Specific Peptides for CNOT7 Gene

Domains for CNOT7 Gene

Protein Domains for CNOT7 Gene

Suggested Antigen Peptide Sequences for CNOT7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIV1

UniProtKB/Swiss-Prot:

CNOT7_HUMAN :
  • Q9UIV1
Family:
  • Belongs to the CAF1 family.
genes like me logo Genes that share domains with CNOT7: view

No data available for Gene Families for CNOT7 Gene

Function for CNOT7 Gene

Molecular function for CNOT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function: Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Enzyme Numbers (IUBMB) for CNOT7 Gene

Gene Ontology (GO) - Molecular Function for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IDA 15769875
GO:0003676 nucleic acid binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9820826
GO:0003723 RNA binding IEA --
GO:0004532 exoribonuclease activity IDA 19276069
genes like me logo Genes that share ontologies with CNOT7: view
genes like me logo Genes that share phenotypes with CNOT7: view

Animal Models for CNOT7 Gene

MGI Knock Outs for CNOT7:

Animal Model Products

CRISPR Products

miRNA for CNOT7 Gene

miRTarBase miRNAs that target CNOT7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNOT7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CNOT7 Gene

Localization for CNOT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT7 Gene

Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT7 Gene COMPARTMENTS Subcellular localization image for CNOT7 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IDA 9820826
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CNOT7: view

Pathways for CNOT7 Gene

genes like me logo Genes that share pathways with CNOT7: view

Pathways by source for CNOT7 Gene

1 Qiagen pathway for CNOT7 Gene
1 KEGG pathway for CNOT7 Gene

Gene Ontology (GO) - Biological Process for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0005975 carbohydrate metabolic process TAS 9820826
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CNOT7: view

Compounds for CNOT7 Gene

(1) Novoseek inferred chemical compound relationships for CNOT7 Gene

Compound -log(P) Hits PubMed IDs
carbon 11.2 2
genes like me logo Genes that share compounds with CNOT7: view

Transcripts for CNOT7 Gene

Unigene Clusters for CNOT7 Gene

CCR4-NOT transcription complex, subunit 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNOT7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1:
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10: - - - -
SP11: - - - - -
SP12: -
SP13:

ExUns: 12c ^ 13a · 13b ^ 14
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CNOT7 Gene

GeneLoc Exon Structure for
CNOT7
ECgene alternative splicing isoforms for
CNOT7

Expression for CNOT7 Gene

mRNA expression in normal human tissues for CNOT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT7 Gene

SOURCE GeneReport for Unigene cluster for CNOT7 Gene Hs.645009

genes like me logo Genes that share expressions with CNOT7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNOT7 Gene

Orthologs for CNOT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT7 35
  • 100 (n)
  • 100 (a)
CNOT7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT7 35
  • 96.73 (n)
  • 99.65 (a)
CNOT7 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT7 35
  • 96.73 (n)
  • 100 (a)
CNOT7 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot7 35
  • 93.1 (n)
  • 99.65 (a)
Cnot7 16
Cnot7 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT7 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot7 35
  • 92.87 (n)
  • 99.65 (a)
chicken
(Gallus gallus)
Aves CNOT7 35
  • 88.3 (n)
  • 100 (a)
CNOT7 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNOT7 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot7 35
  • 82.57 (n)
  • 96.84 (a)
zebrafish
(Danio rerio)
Actinopterygii cnot7 35
  • 80.87 (n)
  • 95.77 (a)
cnot7 36
  • 95 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011413 35
  • 66.54 (n)
  • 77.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pop2 35
  • 66.03 (n)
  • 75.38 (a)
Pop2 36
  • 53 (a)
OneToMany
CG5684 37
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea ccf-1 35
  • 54.99 (n)
  • 49.81 (a)
ccf-1 36
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POP2 36
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10960 35
  • 55.39 (n)
  • 52.63 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09001 35
  • 57.01 (n)
  • 53.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes caf1 35
  • 59.25 (n)
  • 56.6 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13234 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 72 (a)
OneToMany
Species with no ortholog for CNOT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT7 Gene

ENSEMBL:
Gene Tree for CNOT7 (if available)
TreeFam:
Gene Tree for CNOT7 (if available)

Paralogs for CNOT7 Gene

Paralogs for CNOT7 Gene

Selected SIMAP similar genes for CNOT7 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CNOT7 Gene

genes like me logo Genes that share paralogs with CNOT7: view

Variants for CNOT7 Gene

Sequence variations from dbSNP and Humsavar for CNOT7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs6837 -- 17,229,481(+) ATTAC(C/T)GTAAA utr-variant-3-prime
rs971574 -- 17,241,055(+) AGACT(C/G)TGCGT intron-variant
rs1043083 -- 17,229,505(-) AGACC(A/G)GAGCA utr-variant-3-prime
rs1043093 -- 17,229,247(-) AGGCT(G/T)CAAAA utr-variant-3-prime
rs2157633 -- 17,229,003(+) GAAAG(A/G)AGAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CNOT7 Gene

Variant ID Type Subtype PubMed ID
nsv831244 CNV Gain 17160897

Relevant External Links for CNOT7 Gene

HapMap Linkage Disequilibrium report
CNOT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT7 Gene

Disorders for CNOT7 Gene

No disorders were found for CNOT7 Gene.

No data available for UniProtKB/Swiss-Prot for CNOT7 Gene

Publications for CNOT7 Gene

  1. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. (PMID: 9820826) Bogdan J.A. … Dicker I.B. (Biochem. J. 1998) 3 4 23
  2. hCAF1, a new regulator of PRMT1-dependent arginine methylation. (PMID: 17264152) Robin-Lespinasse Y. … Le Romancer M. (J. Cell. Sci. 2007) 2 3 23
  3. Sequence identification of 2,375 human brain genes. (PMID: 1538749) Adams M.D. … Venter J.C. (Nature 1992) 2 3
  4. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. (PMID: 10602502) Ikematsu N. … Yamamoto T. (Oncogene 1999) 3 23
  5. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PMID: 11429045) Yoshida Y. … Yamamoto T. (Jpn. J. Cancer Res. 2001) 3 23

Products for CNOT7 Gene

  • Addgene plasmids for CNOT7

Sources for CNOT7 Gene

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