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Aliases for CNOT7 Gene

Aliases for CNOT7 Gene

  • CCR4-NOT Transcription Complex, Subunit 7 2 3
  • CCR4-Associated Factor 1 3 4
  • BTG1 Binding Factor 1 2 3
  • BTG1-Binding Factor 1 3 4
  • CAF-1 3 4
  • Caf1a 3 4
  • CAF1 3 4
  • Carbon Catabolite Repressor Protein (CCR4)-Associative Factor 1 3
  • EC 3.1.13.4 4
  • HCAF-1 3

External Ids for CNOT7 Gene

Previous HGNC Symbols for CNOT7 Gene

  • CAF1

Previous GeneCards Identifiers for CNOT7 Gene

  • GC08M016980
  • GC08M017166
  • GC08M017097
  • GC08M017131
  • GC08M017086
  • GC08M015631

Summaries for CNOT7 Gene

Entrez Gene Summary for CNOT7 Gene

  • The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

GeneCards Summary for CNOT7 Gene

CNOT7 (CCR4-NOT Transcription Complex, Subunit 7) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT8.

UniProtKB/Swiss-Prot for CNOT7 Gene

  • Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Gene Wiki entry for CNOT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT7 Gene

Genomics for CNOT7 Gene

Regulatory Elements for CNOT7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNOT7 Gene

Chromosome:
8
Start:
17,224,964 bp from pter
End:
17,246,878 bp from pter
Size:
21,915 bases
Orientation:
Minus strand

Genomic View for CNOT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNOT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT7 Gene

Proteins for CNOT7 Gene

  • Protein details for CNOT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIV1-CNOT7_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 7
    Protein Accession:
    Q9UIV1
    Secondary Accessions:
    • A8MZM5
    • B3KMP1
    • B3KN35
    • D3DSP6
    • G3V108
    • Q7Z530

    Protein attributes for CNOT7 Gene

    Size:
    285 amino acids
    Molecular mass:
    32745 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Binds 2 divalent metal cations per subunit with RNAase activity being higher in presence of Mn(2+) than of Mg(2+) or Co(2+).;
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. In the complex, interacts directly with CNOT1. Interacts with AGO2, TOB1, BTG1, BTG2 and NANOS2.
    SequenceCaution:
    • Sequence=AAF01500.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT7 Gene

    Alternative splice isoforms for CNOT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT7 Gene

Proteomics data for CNOT7 Gene at MOPED

Post-translational modifications for CNOT7 Gene

  • Ubiquitination at Lys 33, Lys 206, and Lys 240
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CNOT7 Gene

Domains & Families for CNOT7 Gene

Gene Families for CNOT7 Gene

Protein Domains for CNOT7 Gene

Suggested Antigen Peptide Sequences for CNOT7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIV1

UniProtKB/Swiss-Prot:

CNOT7_HUMAN :
  • Belongs to the CAF1 family.
Family:
  • Belongs to the CAF1 family.
genes like me logo Genes that share domains with CNOT7: view

Function for CNOT7 Gene

Molecular function for CNOT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function:
Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Enzyme Numbers (IUBMB) for CNOT7 Gene

Gene Ontology (GO) - Molecular Function for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IDA 15769875
GO:0003676 nucleic acid binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9820826
GO:0003723 RNA binding IEA --
GO:0004532 exoribonuclease activity IDA 19276069
genes like me logo Genes that share ontologies with CNOT7: view
genes like me logo Genes that share phenotypes with CNOT7: view

Animal Models for CNOT7 Gene

MGI Knock Outs for CNOT7:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNOT7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CNOT7 Gene

Localization for CNOT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT7 Gene

Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT7 Gene COMPARTMENTS Subcellular localization image for CNOT7 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IDA 9820826
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CNOT7: view

Pathways & Interactions for CNOT7 Gene

genes like me logo Genes that share pathways with CNOT7: view

Pathways by source for CNOT7 Gene

1 Qiagen pathway for CNOT7 Gene
1 KEGG pathway for CNOT7 Gene

Gene Ontology (GO) - Biological Process for CNOT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0005975 carbohydrate metabolic process TAS 9820826
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CNOT7: view

No data available for SIGNOR curated interactions for CNOT7 Gene

Drugs & Compounds for CNOT7 Gene

(1) Additional Compounds for CNOT7 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carbon
genes like me logo Genes that share compounds with CNOT7: view

Transcripts for CNOT7 Gene

Unigene Clusters for CNOT7 Gene

CCR4-NOT transcription complex, subunit 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNOT7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1:
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10: - - - -
SP11: - - - - -
SP12: -
SP13:

ExUns: 12c ^ 13a · 13b ^ 14
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CNOT7 Gene

GeneLoc Exon Structure for
CNOT7
ECgene alternative splicing isoforms for
CNOT7

Expression for CNOT7 Gene

mRNA expression in normal human tissues for CNOT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNOT7 Gene

This gene is overexpressed in Bone (22.6) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT7 Gene



SOURCE GeneReport for Unigene cluster for CNOT7 Gene Hs.645009

genes like me logo Genes that share expression patterns with CNOT7: view

Protein tissue co-expression partners for CNOT7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNOT7 Gene

Orthologs for CNOT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNOT7 35
  • 96.73 (n)
  • 99.65 (a)
CNOT7 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT7 35
  • 96.73 (n)
  • 100 (a)
CNOT7 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot7 35
  • 93.1 (n)
  • 99.65 (a)
Cnot7 16
Cnot7 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNOT7 35
  • 100 (n)
  • 100 (a)
CNOT7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot7 35
  • 92.87 (n)
  • 99.65 (a)
oppossum
(Monodelphis domestica)
Mammalia CNOT7 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT7 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNOT7 35
  • 88.3 (n)
  • 100 (a)
CNOT7 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNOT7 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot7 35
  • 82.57 (n)
  • 96.84 (a)
zebrafish
(Danio rerio)
Actinopterygii cnot7 35
  • 80.87 (n)
  • 95.77 (a)
cnot7 36
  • 95 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5684 37
  • 75 (a)
Pop2 35
  • 66.03 (n)
  • 75.38 (a)
Pop2 36
  • 53 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011413 35
  • 66.54 (n)
  • 77.95 (a)
worm
(Caenorhabditis elegans)
Secernentea ccf-1 35
  • 54.99 (n)
  • 49.81 (a)
ccf-1 36
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POP2 36
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10960 35
  • 55.39 (n)
  • 52.63 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13234 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09001 35
  • 57.01 (n)
  • 53.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes caf1 35
  • 59.25 (n)
  • 56.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 72 (a)
OneToMany
Species with no ortholog for CNOT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT7 Gene

ENSEMBL:
Gene Tree for CNOT7 (if available)
TreeFam:
Gene Tree for CNOT7 (if available)

Paralogs for CNOT7 Gene

Paralogs for CNOT7 Gene

(1) SIMAP similar genes for CNOT7 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CNOT7 Gene

genes like me logo Genes that share paralogs with CNOT7: view

Variants for CNOT7 Gene

Sequence variations from dbSNP and Humsavar for CNOT7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs6837 -- 17,229,481(+) ATTAC(C/T)GTAAA utr-variant-3-prime
rs971574 -- 17,241,055(+) AGACT(C/G)TGCGT intron-variant
rs1043083 -- 17,229,505(-) AGACC(A/G)GAGCA utr-variant-3-prime
rs1043093 -- 17,229,247(-) AGGCT(G/T)CAAAA utr-variant-3-prime
rs2157633 -- 17,229,003(+) GAAAG(A/G)AGAAA downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CNOT7 Gene

Variant ID Type Subtype PubMed ID
nsv831244 CNV Gain 17160897

Variation tolerance for CNOT7 Gene

Residual Variation Intolerance Score: 39.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNOT7 Gene

HapMap Linkage Disequilibrium report
CNOT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT7 Gene

Disorders for CNOT7 Gene

Relevant External Links for CNOT7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNOT7
genes like me logo Genes that share disorders with CNOT7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT7 Gene

Publications for CNOT7 Gene

  1. hCAF1, a new regulator of PRMT1-dependent arginine methylation. (PMID: 17264152) Robin-Lespinasse Y. … Le Romancer M. (J. Cell. Sci. 2007) 2 23 67
  2. CUCU modification of mRNA promotes decapping and transcript degradation in Aspergillus nidulans. (PMID: 19901075) Morozov I.Y. … Caddick M.X. (Mol. Cell. Biol. 2010) 23 67
  3. Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans. (PMID: 20233300) Morozov I.Y. … Caddick M.X. (Mol. Microbiol. 2010) 23 67
  4. A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells. (PMID: 18442996) Schwede A. … Clayton C. (Nucleic Acids Res. 2008) 23 67
  5. Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells. (PMID: 16786164) Vadgama J.V. … Wu Y. (Int. J. Mol. Med. 2006) 23 67

Products for CNOT7 Gene

Sources for CNOT7 Gene

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