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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNOT7 Gene

protein-coding   GIFtS: 59
GCID: GC08M017086

CCR4-NOT Transcription Complex, Subunit 7


(Previous symbol: CAF1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CCR4-NOT Transcription Complex, Subunit 71 2     CCR4-Associated Factor 12 3
CAF11 2 3 5     Carbon Catabolite Repressor Protein (CCR4)-Associative Factor 12
BTG1 Binding Factor 11 2     CCR4-NOT Transcription Complex Subunit 72
CAF-12 3     hCAF-12
Caf1a2 3     EC 3.1.13.43
BTG1-Binding Factor 12 3     

External Ids:    HGNC: 141011   Entrez Gene: 298832   Ensembl: ENSG000001987917   OMIM: 6049135   UniProtKB: Q9UIV13   

Export aliases for CNOT7 gene to outside databases

Previous GC identifers: GC08M016980 GC08M017166 GC08M017097 GC08M017131 GC08M015631


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNOT7 Gene:
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which
negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the
anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation
associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this
gene results in two transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for CNOT7 Gene: 
CNOT7 (CCR4-NOT transcription complex, subunit 7) is a protein-coding gene. Diseases associated with CNOT7 include male infertility, and infertility, and among its related super-pathways are Deadenylation-dependent mRNA decay and Metabolism of RNA. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and signal transducer activity. An important paralog of this gene is CNOT8.

UniProtKB/Swiss-Prot: CNOT7_HUMAN, Q9UIV1
Function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be
partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major
cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation,
miRNA-mediated repression, translational repression during translational initiation and general transcription
regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during
translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression.
Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative
activity

Gene Wiki entry for CNOT7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNOT7 gene promoter:
         HFH-3   RP58   Pax-5   Cdc5   LCR-F1   FOXI1   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNOT7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNOT7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21.3   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22-p21.3

CNOT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M017086:  view genomic region     (about GC identifiers)

Start:
17,086,737 bp from pter      End:
17,104,387 bp from pter
Size:
17,651 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNOT7_HUMAN, Q9UIV1 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 7  
Size: 285 amino acids; 32745 Da
Cofactor: Binds 2 divalent metal cations per subunit with RNAase acticity being higher in presence of Mn(2+) than
of Mg(2+) or Co(2+)
Subunit: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of
probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L,
and CNOT7 or CNOT8. In the complex, interacts directly with CNOT1. Interacts with AGO2, TOB1, BTG1, BTG2 and
NANOS2
Subcellular location: Nucleus. Cytoplasm, P-body (By similarity). Note=NANOS2 promotes its localization to P-body
(By similarity)
Sequence caution: Sequence=AAF01500.1; Type=Frameshift; Positions=4;
2 PDB 3D structures from and Proteopedia for CNOT7:
2D5R (3D)        4GMJ (3D)    
Secondary accessions: A8MZM5 B3KMP1 B3KN35 D3DSP6 G3V108 Q7Z530
Alternative splicing: 2 isoforms:  Q9UIV1-1   Q9UIV1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNOT7: NX_Q9UIV1

Explore proteomics data for CNOT7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UIV1

  • CNOT7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNOT7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_037486.2  NP_473367.2  

    ENSEMBL proteins: 
     ENSP00000355279   ENSP00000430263   ENSP00000429093   ENSP00000429632   ENSP00000428147  
     ENSP00000430160   ENSP00000428783   ENSP00000429079  
    Reactome Protein details: Q9UIV1
    Human Recombinant Protein Products for CNOT7: 
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    Novus Biologicals CNOT7 Proteins
    Novus Biologicals CNOT7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CNOT7
    Cloud-Clone Corp. Proteins for CNOT7 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005634nucleus IDA9820826
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0030014CCR4-NOT complex NAS9820826

    CNOT7 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for CNOT7 

    Assay Products for CNOT7: 
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    Cloud-Clone Corp. ELISAs for CNOT7 
    Cloud-Clone Corp. CLIAs for CNOT7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006941 RNase_CAF1
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UIV1

    ProtoNet protein and cluster: Q9UIV1

    1 Blocks protein domain: IPB006941 CAF1 family ribonuclease

    UniProtKB/Swiss-Prot: CNOT7_HUMAN, Q9UIV1
    Similarity: Belongs to the CAF1 family


    CNOT7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNOT7_HUMAN, Q9UIV1
    Function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be
    partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major
    cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation,
    miRNA-mediated repression, translational repression during translational initiation and general transcription
    regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during
    translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression.
    Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative
    activity
    Catalytic activity: Exonucleolytic cleavage of poly(A) to 5'-AMP

         Enzyme Number (IUBMB): EC 3.1.13.41

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00001753'-5'-exoribonuclease activity IDA15769875
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9820826
    GO:0003723RNA binding IEA--
    GO:0004532exoribonuclease activity IDA19276069
         
    CNOT7 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cnot7):
     cellular  endocrine/exocrine gland  reproductive system 

    CNOT7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cnot7tm1Jpr for CNOT7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNOT7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNOT7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNOT7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNOT7 

    miRNA
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    8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT7 (see all 69):
    hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-1244 hsa-miR-93 hsa-miR-3613-3p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCNOT7 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CNOT7 (NM_013354)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT7
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                         Customized lentivirus expression plasmids for stable overexpression of CNOT7 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CNOT7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.49
    Deadenylation of mRNA0.47
    RNA degradation0.49
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.47
    4Cyclins and Cell Cycle Regulation
    Cell Cycle Control by BTG Proteins0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CNOT7
        Cell Cycle Control by BTG Proteins

    5        Reactome Pathways for CNOT7
        Deadenylation of mRNA
    Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    1         Kegg Pathway  (Kegg details for CNOT7):
        RNA degradation


    CNOT7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNOT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for CNOT7 (Q9UIV11, 2, 3 ENSP000003552794) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOB1P506161, 2, 3, ENSP000002689574EBI-2105113,EBI-723281 MINT-8173967 MINT-8176376 MINT-8176406 I2D: score=3 STRING: ENSP00000268957
    CNOT1A5YKK61, 3, ENSP000003209494STRING: ENSP00000320949 EBI-2105113,EBI-1222758 I2D: score=1 
    CNOT6Q9ULM61, 3, ENSP000002619514EBI-2105113,EBI-2104530 I2D: score=1 STRING: ENSP00000261951
    BTG1P623241, 2, 3, ENSP000002560154EBI-2105113,EBI-742279 MINT-8249663 I2D: score=4 STRING: ENSP00000256015
    CPEB3Q8NE352, ENSP000002659974MINT-8173967 MINT-8176376 MINT-8176406 STRING: ENSP00000265997
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA IEA--
    GO:0005975carbohydrate metabolic process TAS9820826
    GO:0006351transcription, DNA-dependent IEA--

    CNOT7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CNOT7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNOT7

    1 Novoseek inferred chemical compound relationship for CNOT7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbon 11.2 3 11267995 (1), 9820826 (1)

    Search CenterWatch for drugs/clinical trials and news about CNOT7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNOT7 gene (2 alternative transcripts): 
    NM_013354.5  NM_054026.2  

    Unigene Cluster for CNOT7:

    CCR4-NOT transcription complex, subunit 7
    Hs.645009  [show with all ESTs]
    Unigene Representative Sequence: BC060852
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361272(uc003wxf.1 uc003wxg.1) ENST00000518541 ENST00000523917(uc003wxh.1)
    ENST00000519954 ENST00000519918 ENST00000522062 ENST00000524358 ENST00000519998(uc003wxi.1)
    ENST00000518021 ENST00000520178 ENST00000518885 ENST00000523649
    miRNA
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    8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT7 (see all 69):
    hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-1244 hsa-miR-93 hsa-miR-3613-3p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCNOT7 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT7

    Additional mRNA sequence: 

    AF086915.1 AK001209.1 AK021808.1 AK023466.1 AK023561.1 AK225893.1 AL833642.1 BC007315.2 
    BC060852.1 BC070187.1 BT006685.1 L46722.1 

    24/31 DOTS entries (see all 31):

    DT.92447025  DT.95237293  DT.92447026  DT.92409785  DT.92410293  DT.91874486  DT.97792166  DT.100828234 
    DT.121478489  DT.121478452  DT.100828237  DT.121478459  DT.100828232  DT.102830616  DT.91993025  DT.75157876 
    DT.100828231  DT.100828238  DT.100828239  DT.121235536  DT.121314489  DT.95148881  DT.100745207  DT.100828236 

    24/388 AceView cDNA sequences (see all 388):

    NM_013354 AU123461 BU740104 AA187926 BG191334 AU119313 R27369 BX953872 
    AI140546 BE886997 F31240 AA173958 CN480686 BU615669 BX116322 BC070187 
    BQ924072 BU165351 AA165430 CB116729 AA419602 BQ231006 R12076 AW269159 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT7 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b ^ 12a · 12b ·
    SP1:                                                                                                                                                            
    SP2:                                -     -     -     -                       -                                                                                 
    SP3:                                            -     -                       -     -     -     -                                                               
    SP4:              -     -     -     -     -     -     -                       -     -     -     -                                                               
    SP5:              -     -     -     -     -     -     -                       -                                                                                 

    ExUns: 12c ^ 13a · 13b ^ 14
    SP1:              -         
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CNOT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNOT7 expression in normal human tissues (normalized intensities)      CNOT7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATTACAGT
    CNOT7 Expression
    About this image


    CNOT7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Chorion (Extraembryonic Tissues)
             chorion villus cells   
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer

    See CNOT7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNOT7

    SOURCE GeneReport for Unigene cluster: Hs.645009
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNOT7 gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnot71 , 5 CCR4-NOT transcription complex, subunit 71, 5 93.1(n)1
    99.65(a)1
      8 (23.89 cM)5
    189831  NM_011135.41  NP_035265.11 
     404925405 
    chicken
    (Gallus gallus)
    Aves CNOT71 CCR4-NOT transcription complex, subunit 7 88.3(n)
    100(a)
      422733  NM_001006454.1  NP_001006454.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNOT76
    Uncharacterized protein
    100(a)
    1 ↔ 1
    5(108213796-108228304)
    zebrafish
    (Danio rerio)
    Actinopterygii cnot71 CCR4-NOT transcription complex, subunit 7 80.87(n)
    95.77(a)
      768119  NM_001077255.1  NP_001070723.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56843
    Pop21
    general RNA polymerase II
    transcription factor3
    CG5684-PA1
    75(a)3
    66.03(n)1
    75.38(a)1
      68F13
    393661  NM_140281.21  NP_648538.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ccf-11 Protein CCF-1 54.86(n)
    49.42(a)
      176625  NM_067152.5  NP_499553.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POP26
    RNase of the DEDD superfamily, subunit of the Ccr4...
    24(a)
    1 → many
    XIV(719346-720647)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G807801 putative CCR4-associated factor 1-6 57.66(n)
    59.07(a)
      844417  NM_106726.4  NP_178193.1 
    rice
    (Oryza sativa)
    Liliopsida AK099984.12   -- 71.58(n)    AK099984.1 


    ENSEMBL Gene Tree for CNOT7 (if available)
    TreeFam Gene Tree for CNOT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNOT7 gene
    CNOT82  
    1 SIMAP similar gene for CNOT7 using alignment to 7 protein entries:     CNOT7_HUMAN (see all proteins):
    CNOT8

    CNOT7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CNOT7
    PGOHUM00000244864 PGOHUM00000241370


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/389 SNPs in CNOT7 are shown (see all 389)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894420981,2
    --17086301(+) GCATTG/TATTTC 1 -- ds50010--------
    rs1806780391,2
    --17086330(+) TTTAAA/GTATTA 1 -- ds50010--------
    rs1427153331,2
    --17086485(+) ATATCC/GTTCGG 1 -- ds50010--------
    rs21576331,2
    C,F,H--17086512(+) GAAAGG/AAGAAA 1 -- ds50018Minor allele frequency- A:0.02EA NA NS 594
    rs624973511,2
    C,F--17086601(+) CAGACT/GGATTT 1 -- ds50012Minor allele frequency- G:0.18NA 122
    rs749482521,2
    C,F--17086642(+) TTAATG/AAAGGA 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs735556501,2
    C,F--17086738(+) AACATT/CTATAA 1 -- ds50012Minor allele frequency- C:0.09WA 120
    rs10430931,2
    C,F,H--17086756(-) AGGCTT/GCAAAA 1 -- ut3117Minor allele frequency- G:0.05NA NS EA 1760
    rs1442650971,2
    C--17086811(+) AAATA-/ATGTTTT 1 -- ut310--------
    rs1836441041,2
    --17086909(+) GAGATG/TTGCTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CNOT7 (17086737 - 17104387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CNOT7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831244CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604913    OMIM disorders: --

    4 diseases for CNOT7:    About MalaCards
    male infertility    infertility    colorectal cancer    breast cancer


    CNOT7 for disorders           About GeneDecksing


    Export disorders for CNOT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNOT7 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with CNOT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hCAF1, a new regulator of PRMT1-dependent arginine methylation. (PubMed id 17264152)1, 3, 9 Robin-Lespinasse Y....Le Romancer M. (2007)
    2. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. (PubMed id 9820826)1, 2, 9 Bogdan J.A.... Dicker I.B. (1998)
    3. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4- not complex. (PubMed id 23236473)1, 2 Doidge R.... Winkler G.S. (2012)
    4. Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)1, 2 Lau N.C....Timmers H.T. (2009)
    5. Structural Basis for the Antiproliferative Activity of the Tob-hCaf1 Complex. (PubMed id 19276069)1, 2 Horiuchi M....Inagaki F. (2009)
    6. The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 hav e overlapping roles and modulate cell proliferation. (PubMed id 19605561)1, 2 Aslam A....Winkler G.S. (2009)
    7. Conservation of the deadenylase activity of proteins of the Caf1 family in human. (PubMed id 15769875)1, 2 Bianchin C....Corbo L. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 3 Albert T.K....Timmers H.T. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29883 HGNC: 14101 AceView: CNOT7 Ensembl:ENSG00000198791 euGenes: HUgn29883
    ECgene: CNOT7 Kegg: 29883 H-InvDB: CNOT7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNOT7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CNOT7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNOT7 gene:
    Search GeneIP for patents involving CNOT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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