Aliases for CNOT6L Gene
External Ids for CNOT6L Gene
Previous GeneCards Identifiers for CNOT6L Gene
GeneCards Summary for CNOT6L Gene
CNOT6L (CCR4-NOT Transcription Complex Subunit 6 Like) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include poly(A)-specific ribonuclease activity. An important paralog of this gene is PDE12.
UniProtKB/Swiss-Prot for CNOT6L Gene
Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.