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Aliases for CNOT6L Gene

Aliases for CNOT6L Gene

  • CCR4-NOT Transcription Complex Subunit 6 Like 2 3
  • Carbon Catabolite Repressor Protein 4 Homolog B 3 4
  • CCR4-NOT Transcription Complex, Subunit 6-Like 2 3
  • CCR4b 3 4
  • CCR4-NOT Transcription Complex Subunit 6-Like 5
  • EC 3.1.13.4 4

External Ids for CNOT6L Gene

Previous GeneCards Identifiers for CNOT6L Gene

  • GC04M078548
  • GC04M078828
  • GC04M079030
  • GC04M079096
  • GC04M078995
  • GC04M078853
  • GC04M078634
  • GC04M074386

Summaries for CNOT6L Gene

GeneCards Summary for CNOT6L Gene

CNOT6L (CCR4-NOT Transcription Complex Subunit 6 Like) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include poly(A)-specific ribonuclease activity. An important paralog of this gene is PDE12.

UniProtKB/Swiss-Prot for CNOT6L Gene

  • Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT6L Gene

Genomics for CNOT6L Gene

Regulatory Elements for CNOT6L Gene

Enhancers for CNOT6L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CNOT6L on UCSC Golden Path with GeneCards custom track

Promoters for CNOT6L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNOT6L on UCSC Golden Path with GeneCards custom track

Genomic Location for CNOT6L Gene

Chromosome:
4
Start:
77,713,387 bp from pter
End:
77,820,238 bp from pter
Size:
106,852 bases
Orientation:
Minus strand

Genomic View for CNOT6L Gene

Genes around CNOT6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT6L Gene

Proteins for CNOT6L Gene

  • Protein details for CNOT6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LI5-CNO6L_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 6-like
    Protein Accession:
    Q96LI5
    Secondary Accessions:
    • Q9UF92

    Protein attributes for CNOT6L Gene

    Size:
    555 amino acids
    Molecular mass:
    63001 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. Interacts with NANOS2 (By similarity).
    Miscellaneous:
    • Depletion of CNOT6L causes cell growth defect.

    Three dimensional structures from OCA and Proteopedia for CNOT6L Gene

    Alternative splice isoforms for CNOT6L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT6L Gene

Proteomics data for CNOT6L Gene at MOPED

Post-translational modifications for CNOT6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNOT6L Gene

No data available for DME Specific Peptides for CNOT6L Gene

Domains & Families for CNOT6L Gene

Gene Families for CNOT6L Gene

Protein Domains for CNOT6L Gene

Suggested Antigen Peptide Sequences for CNOT6L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LI5

UniProtKB/Swiss-Prot:

CNO6L_HUMAN :
  • Belongs to the CCR4/nocturin family.
  • Contains 4 LRR (leucine-rich) repeats.
Family:
  • Belongs to the CCR4/nocturin family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CNOT6L: view

Function for CNOT6L Gene

Molecular function for CNOT6L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function:
Has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.

Enzyme Numbers (IUBMB) for CNOT6L Gene

genes like me logo Genes that share phenotypes with CNOT6L: view

Animal Model Products

miRNA for CNOT6L Gene

miRTarBase miRNAs that target CNOT6L

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT6L Gene

Localization for CNOT6L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT6L Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT6L Gene COMPARTMENTS Subcellular localization image for CNOT6L gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for CNOT6L Gene

Pathways & Interactions for CNOT6L Gene

genes like me logo Genes that share pathways with CNOT6L: view

Gene Ontology (GO) - Biological Process for CNOT6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006397 mRNA processing IEA --
GO:0010467 gene expression TAS --
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly IMP 21233283
genes like me logo Genes that share ontologies with CNOT6L: view

No data available for SIGNOR curated interactions for CNOT6L Gene

Drugs & Compounds for CNOT6L Gene

No Compound Related Data Available

Transcripts for CNOT6L Gene

Unigene Clusters for CNOT6L Gene

CCR4-NOT transcription complex, subunit 6-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT6L Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1: - - -
SP2:
SP3: - -
SP4:
SP5:
SP6: - - -

Relevant External Links for CNOT6L Gene

GeneLoc Exon Structure for
CNOT6L
ECgene alternative splicing isoforms for
CNOT6L

Expression for CNOT6L Gene

mRNA expression in normal human tissues for CNOT6L Gene

Protein differential expression in normal tissues from HIPED for CNOT6L Gene

This gene is overexpressed in CD4 Tcells (26.3), Monocytes (19.9), and CD8 Tcells (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CNOT6L Gene



SOURCE GeneReport for Unigene cluster for CNOT6L Gene Hs.592519

mRNA Expression by UniProt/SwissProt for CNOT6L Gene

Q96LI5-CNO6L_HUMAN
Tissue specificity: Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus.
genes like me logo Genes that share expression patterns with CNOT6L: view

Protein tissue co-expression partners for CNOT6L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CNOT6L Gene

Orthologs for CNOT6L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNOT6L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNOT6L 35
  • 98.5 (n)
  • 100 (a)
CNOT6L 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT6L 35
  • 98.48 (n)
  • 99.82 (a)
CNOT6L 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot6l 35
  • 96.28 (n)
  • 98.02 (a)
Cnot6l 16
Cnot6l 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNOT6L 35
  • 99.88 (n)
  • 100 (a)
CNOT6L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot6l 35
  • 96.06 (n)
  • 98 (a)
oppossum
(Monodelphis domestica)
Mammalia CNOT6L 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT6L 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNOT6L 35
  • 89.69 (n)
  • 96.38 (a)
CNOT6L 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNOT6L 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot6l 35
  • 84.07 (n)
  • 90.21 (a)
Str.16965 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.34621 35
zebrafish
(Danio rerio)
Actinopterygii cnot6l 35
  • 74.57 (n)
  • 83.82 (a)
cnot6l 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004405 35
  • 59.83 (n)
  • 61.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta twin 35
  • 58.85 (n)
  • 59.22 (a)
twin 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ccr-4 35
  • 56.69 (n)
  • 53.23 (a)
ccr-4 36
  • 32 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR288W 35
  • 48.99 (n)
  • 39.67 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15884g 35
  • 48.01 (n)
  • 37.02 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 35
  • 48.46 (n)
  • 37.42 (a)
CCR4 36
  • 21 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07779 35
  • 48.43 (n)
  • 38.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ccr4 35
  • 52.63 (n)
  • 46.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for CNOT6L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT6L Gene

ENSEMBL:
Gene Tree for CNOT6L (if available)
TreeFam:
Gene Tree for CNOT6L (if available)

Paralogs for CNOT6L Gene

Paralogs for CNOT6L Gene

(2) SIMAP similar genes for CNOT6L Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CNOT6L Gene

genes like me logo Genes that share paralogs with CNOT6L: view

Variants for CNOT6L Gene

Sequence variations from dbSNP and Humsavar for CNOT6L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1156059 -- 77,816,817(+) AAAAC(A/C)ATCTT intron-variant
rs924548 -- 77,783,270(+) ttcaa(A/G)aaata intron-variant
rs1295747 -- 77,727,467(+) aggct(A/G)aggca intron-variant
rs1296473 -- 77,714,228(+) GAATT(C/T)TTTAA utr-variant-3-prime
rs1298043 -- 77,714,255(+) GAAAA(A/T)AAATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CNOT6L Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv829976 CNV Gain 17160897
nsv518757 CNV Loss 19592680
nsv879501 CNV Loss 21882294
esv2752050 CNV Gain 17911159
esv23755 CNV Loss 19812545

Variation tolerance for CNOT6L Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CNOT6L Gene

Disorders for CNOT6L Gene

Relevant External Links for CNOT6L

Genetic Association Database (GAD)
CNOT6L
Human Genome Epidemiology (HuGE) Navigator
CNOT6L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNOT6L

No disorders were found for CNOT6L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT6L Gene

Publications for CNOT6L Gene

  1. The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. (PMID: 21233283) Mittal S. … Winkler G.S. (Mol. Biol. Cell 2011) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. (PMID: 24057671) Chimusa E.R. … Hoal E.G. (Hum. Mol. Genet. 2014) 3
  5. Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1. (PMID: 23591815) Zhou W. … Thiery J.P. (J. Cell. Sci. 2013) 3

Products for CNOT6L Gene

Sources for CNOT6L Gene

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