CNOT6 Gene
protein-coding GIFtS: 57
GCID: GC05P179921
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|
CCR4-NOT transcription complex, subunit 6
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Aliases
for CNOT6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CCR4-NOT Transcription Complex, Subunit 61 2 | | Carbon Catabolite Repression 4 Protein2 | | CCR41 2 3 5 | | CCR4-NOT Transcription Complex Subunit 62 | | KIAA11941 3 5 | | EC 3.1.-.-3 | | Carbon Catabolite Repressor Protein 4 Homolog2 3 | | CCR4 Carbon Catabolite Repression 4-Like3 | | Cytoplasmic Deadenylase2 3 | | EC 3.1.13.48 |
Export aliases for CNOT6 gene to outside databasesPrevious GC identifers: GC00U990842 GC05P179855 GC05P179856 GC05P174644 |
Summaries
for CNOT6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CNOT6:
The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encodedprotein has a 3'-5' RNase activity and prefers polyadenylated substates. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6Function: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability(mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as generaltranscription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptionalactivity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription ismuch smaller, if any
 summary
for CNOT6: Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.
Gene Wiki entry for CNOT6
|
Genomic Views
for CNOT6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CNOT6 gene promoter:
AP-2rep FOXF2 AP-4 E47 RORalpha1 FOXJ2 (long isoform) Hand1 FOXO1a FOXJ2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNOT6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3CNOT6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P179921: view genomic region
(about GC identifiers)
Start:
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179,921,412 bp from pter |
End:
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180,005,405 bp from pter |
Size:
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83,994 bases |
Orientation:
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plus strand |
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Proteins
for CNOT6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6 (See
protein sequence)Recommended Name: CCR4-NOT transcription complex subunit 6 Size: 557 amino acids; 63307 Da
Cofactor: Magnesium
Subunit: Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 andCNOT8. Interacts with UNR. Interacts with ZNF335
Subcellular location: Cytoplasm (Probable). Nucleus (Probable)
Secondary accessions: A7MD46 D3DWR0Explore the universe of human proteins at neXtProt for CNOT6: NX_Q9ULM6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9ULM6
2 DME Specific Peptides for CNOT6 (Q9ULM6)
CNOT6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056270.2
ENSEMBL proteins: ENSP00000377024 ENSP00000422087 ENSP00000261951 Reactome Protein details: Q9ULM6
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CNOT6 for ontologies About GeneDecksing
CNOT6 Antibody Products:
Assay Products for CNOT6: |
Protein
Domains /
Families
for CNOT6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CNOT6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9ULM6ProtoNet protein and cluster: Q9ULM6 UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6Similarity: Belongs to the CCR4/nocturin familySimilarity: Contains 4 LRR (leucine-rich) repeats |
Function
for CNOT6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6Function: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability(mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as generaltranscription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptionalactivity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription ismuch smaller, if anyEnzyme Numbers (IUBMB): EC 3.1.-.-1 EC 3.1.13.42
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CNOT6 (NM_015455) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNOT6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CNOT6 for ontologies About GeneDecksing
|
Pathways & Interactions
for CNOT6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | | | 2 | Metabolism of mRNA | | | 3 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for CNOT6
1 
Kegg Pathway (Kegg details for CNOT6):
CNOT6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNOT6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/127 Interacting proteins for CNOT6 (Q9ULM63 ENSP000002619514) via UniProtKB, MINT, STRING, and/or I2D (see all 127)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
TAS | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0010467 | gene expression |
TAS | -- |
CNOT6 for ontologies About GeneDecksing
|
Drugs & Compounds
for CNOT6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for CNOT6 available from Tocris Bioscience About this table
1 HMDB Compound for CNOT6 About this table
Search CenterWatch for drugs/clinical trials and news about CNOT6
|
Transcripts
for CNOT6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CNOT6 gene: NM_015455.3 Unigene Cluster for CNOT6: CCR4-NOT transcription complex, subunit 6 Hs.608380 [show with all ESTs]Unigene Representative Sequence: BC1524696 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000510148 ENST00000393356(uc010jld.3) ENST00000507016 ENST00000502447
ENST00000504343 ENST00000261951(uc003mlx.3 uc010jle.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CNOT6 (NM_015455) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNOT6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT6 |
Additional cDNA sequence: AB033020.1 AK023599.1 AK314752.1 AL110144.1 BC015331.1 BC027476.1 BC073142.1 BC090918.1 BC114958.1 BC152469.1 10 DOTS entries: DT.115578 DT.101979531 DT.99934212 DT.100775630 DT.101957004 DT.92435297 DT.92435303 DT.95345830 DT.100737457 DT.97799052 24/268 AceView cDNA sequences (see all 268): CA314233 AA983617 AA884340 CR617731 AW128938 AA603028 AA251375 AI201258 AA459219 AA227814 F03677 BG231763 BM678534 BQ029496 CB306950 BU161680 AI028199 AW173692 AA115459 CA416373 N90713 AA235905 BQ232180 BM974097
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT6 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
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| SP1: | | | - | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CNOT6
|
Expression
for CNOT6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNOT6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCTTCCGT
About this image
See CNOT6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNOT6
SOURCE GeneReport for Unigene cluster: Hs.608380
SABiosciences Custom PCR Arrays for CNOT6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNOT6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNOT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6 |
Orthologs
for CNOT6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CNOT6 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for CNOT6 (if available)
TreeFam Gene Tree for CNOT6 (if available) |
Paralogs
for CNOT6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CNOT6 gene
- ANGEL12 CCRN4L2 PDE122 CNOT6L2 ANGEL22
1 SIMAP similar gene for CNOT6 using alignment to 3 protein entries: CNOT6_HUMAN (see all proteins):CNOT6L
CNOT6 for paralogs About GeneDecksing
|
Genomic Variants
for CNOT6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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